Advancements in ocular blood flow imaging: Clinical applications of laser speckle flowgraphy and optical coherence tomography angiography in retinal and choroidal vascular diseases.

IF 5.9 2区医学 Q1 OPHTHALMOLOGY

Survey of ophthalmology Pub Date : 2025-09-21 DOI:10.1016/j.survophthal.2025.09.016

Yi-Hsuan Tseng, Pei-Liang Wu, Eugene Yu-Chuan Kang, Kuan-Jen Chen, Po-Han Yeh, Ling Yeung, Ming-Hui Sun, Nan-Kai Wang, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu

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引用次数: 0

Abstract

Ocular blood flow imaging techniques have become indispensable in current clinical practice because retinal vascular disturbances have been implicated in the pathophysiology of numerous ocular diseases. In this review, we explore the applications of laser Doppler flowmetry, laser speckle flowgraphy (LSFG), and optical coherence tomography angiography (OCTA), focusing on LSFG and OCTA. Each modality is discussed in detail, including its principles, key parameters, advantages, limitations, and common artifacts. We further evaluated their roles in several ocular diseases, including age-related macular degeneration, polypoidal choroidal vasculopathy, diabetic retinopathy, retinal vein occlusion, retinal artery occlusion, pathologic myopia, glaucoma, non-arteritic anterior ischemic optic neuropathy, and retinopathy of prematurity. Finally, we discuss emerging advancements such as neonatal imaging devices, ultrawide-field OCTA, and artificial intelligence integration in vascular analysis.

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眼血流成像的进展：激光散斑血流成像和光学相干断层血管成像在视网膜和脉络膜血管疾病中的临床应用。

由于视网膜血管紊乱与许多眼部疾病的病理生理有关，因此眼血流成像技术在当前的临床实践中变得不可或缺。本文综述了激光多普勒血流测量、激光散斑血流成像（LSFG）和光学相干断层扫描血管成像（OCTA）在血管造影中的应用，重点介绍了LSFG和OCTA。详细讨论了每种模式，包括其原理、关键参数、优点、限制和常见工件。我们进一步评估了它们在几种眼部疾病中的作用，包括年龄相关性黄斑变性、息肉样脉络膜血管病变、糖尿病视网膜病变、视网膜静脉闭塞、视网膜动脉闭塞、病理性近视、青光眼、非动脉性前缺血性视神经病变和早产儿视网膜病变。最后，我们讨论了新兴的进展，如新生儿成像设备、超宽视场OCTA和血管分析中的人工智能集成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Survey of ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.00%

发文量

138

审稿时长

14.8 weeks

期刊介绍： Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.