与糖尿病黄斑水肿的光学相干断层扫描生物标志物相关的视觉结果:一项系统综述。

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Keean Nanji, Amin Hatamnejad, Justin Grad, Abdullah El-Sayes, Andrew Mihalache, Mohamed Gemae, Ryan Huang, Mark Phillips, Dena Zeraatkar, Rishi Singh, Marion R Munk, SriniVas R Sadda, David Sarraf, Peter Kaiser, Robyn Guymer, Sobha Sivaprasad, Samantha Fraser-Bell, Yih Chung Tham, Sunir J Garg, Tien Yin Wong, Charles C Wykoff, Varun Chaudhary
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引用次数: 0

摘要

我们评估了基线结构光学相干断层扫描(OCT)生物标志物在糖尿病黄斑水肿(DME)患者接受抗血管内皮生长因子、类固醇或激光治疗后6个月、12个月和24个月的功能治疗反应中的价值。我们从一开始就检索了Ovid MEDLINE、EMBASE和Web of Science数据库,以评估基线OCT生物标志物与最佳记录的中央视力(VA)之间的关系。采用了一种综合计票方法,该方法基于与五个字母的最小重要差异相关的影响方向。GRADE指南告知了证据的确定性。纳入96项研究,评估29项生物标志物。没有至少具有“低”确定性的生物标志物与VA改善相关。更大的基线椭球区(EZ)破坏和高反射灶与6个月时VA降低相关,证据确定性为“低”。还有“低”确定性,即12个月时视网膜内层的基线紊乱增加,外限制膜或EZ的基线破坏增加与VA下降有关。没有生物标志物与预后不良相关,至少有“中等”确定性。由于混杂因素控制不充分,以及关于如何定义生物标志物和测量结果缺乏标准化,确定性被降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visual outcomes associated with optical coherence tomography biomarkers in diabetic macular edema: A systematic review.

We evaluated the value of baseline structural optical coherence tomography (OCT) biomarkers in determining functional treatment response at 6,12-, and 24-months following treatment initiation in patients undergoing anti-vascular endothelial growth factor, steroid, or laser treatment for diabetic macular edema (DME). Ovid MEDLINE, EMBASE, and Web of Science databases were searched from inception for studies evaluating the association between baseline OCT biomarkers and best-recorded central visual acuity (VA). A synthesis using vote counting based on the direction of effect in relation to a five-letter minimally important difference was used. GRADE guidelines informed the certainty of evidence. Ninety-six studies evaluating 29 biomarkers were included. No biomarker with at least 'Low' certainty was associated with improved VA. Greater baseline ellipsoid zone (EZ) disruption and hyperreflective foci were associated with decreased VA at 6 months with "Low" certainty of evidence. There was also "Low" certainty that increased baseline disorganization of the retinal inner layers, increased baseline disruption of the external limiting membrane or EZ were associated with decreased VA at 12 months. No biomarker was associated with a poor prognosis with at least 'Moderate' certainty. The certainty was downgraded due to inadequately controlling for confounders and a lack of standardization regarding how biomarkers were defined and outcomes were measured.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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