{"title":"Comment on: \"Postoperative complications of intrascleral intraocular lens fixation: A systematic review and meta-analysis\"","authors":"Fikret Ucar","doi":"10.1016/j.survophthal.2025.03.016","DOIUrl":"10.1016/j.survophthal.2025.03.016","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1267-1268"},"PeriodicalIF":5.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adjustable suture versus nonadjustable suture surgery for childhood strabismus: A meta-analysis","authors":"Chang Liu , Ruohua Yan , Jingjing Jiang","doi":"10.1016/j.survophthal.2025.03.007","DOIUrl":"10.1016/j.survophthal.2025.03.007","url":null,"abstract":"<div><div>We compare the success rate and reoperation rate between adjustable suture (AS) and non-adjustable suture (NAS) in the treatment of strabismus in pediatric patients. We conducted a comprehensive search of scientific databases, including Pubmed, Medline, Embase, Web of Science, and the Cochrane Register of Controlled Trials prior to November 30, 2023., aiming to identify eligible studies for meta-analysis that compared AS versus NAS in patients with strabismus. The differences observed between AS and NAS were quantified as risk differences (RDs) and risk ratios (RRs) along with 95 % confidence intervals (CIs). The data on success rates and reoperation rates were pooled using fixed or random effects model according to the degree of heterogeneity between studies. Subgroup analyses were further performed in patients with exotropia and esotropia. Five studies with 8744 patients were included in this meta-analysis. The success rates observed in the AS group were markedly superior to those in the NAS group, with a RD of 0.17 (95 % CI, 0.11–0.24; P < 0.001) and a RR of 1.26 (95 % CI, 1.15–1.37; P < 0.001); however, there was no significant difference in the reoperation rates between the AS and NAS groups, with a RD of −0.04 (95 % CI, −0.10–0.02; P = 0.19) and a RR of 0.66 (95 % CI, 0.40–1.10; P = 0.11). In the subgroups of exotropia and esotropia, the effect of AS on prognosis was similar. We found that the AS technique can significantly improve the success rate of surgery in the early postoperative period. More evidence-based evidence is needed in the future to confirm whether there is an advantage in the long-term success rate of AS technique.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 859-867"},"PeriodicalIF":5.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Managing Cutibacterium acnes endophthalmitis after cataract surgery: A systematic review and meta-analysis","authors":"Elvia Mastrogiuseppe MD , Ludovico Alisi MD , Annalisa Romaniello MD , Lucrezia Caterino MD , Alessandra Spagnoli PhD , Marco Marenco MD, PhD , Alessandro Lambiase MD, PhD , Danilo Iannetta MD, PhD","doi":"10.1016/j.survophthal.2025.03.012","DOIUrl":"10.1016/j.survophthal.2025.03.012","url":null,"abstract":"<div><div><em>Cutibacterium acnes</em> endophthalmitis is a subtle, indolent infection that typically follows cataract extraction with intraocular lens implantation. Ill-defined symptoms, false-negative cultures, and uncoordinated surgical interventions contribute to a prolonged disease course and poor visual outcomes. A comprehensive literature review spanning from 1986 to September, 2024, evaluated the management of <em>C. acnes</em> infections after intraocular surgeries. The primary outcome was improvement in best corrected visual acuity (BCVA). Secondary outcomes included BCVA, retreatments, follow-up duration, and complications stratified by primary surgical intervention.</div><div>Of the 684 screened articles, 9 retrospective case series were included. Meta-analysis demonstrated significant visual improvement after surgeries (mean difference (MD): 0.62, 95 % CI: 0.15–1.09, <em>p</em> = 0.01). Pars plana vitrectomy (PPV) and PPV combined with IOL removal as first-line approaches yielded superior BCVA outcomes (MD: 0.70, 95 % CI 0.41–1.09, p < 0.00001). PPV-related treatments required fewer retreatments (Odds Ratio (OR): 8.85, 95 % CI: 3.29–23.83, p < 0.0001), but involved longer follow-up duration (MD: −6.53, 95 % CI: −9.57 to −3.49, p < 0.0001). Due to limited data, complications could not be analyzed. The findings suggest that PPV-related treatments significantly improve visual recovery and reduce recurrence rates, albeit with the need for extended follow-up.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 995-1002"},"PeriodicalIF":5.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia-Horung Hung MD , Tanya Jain MD , Anadi Khatri MD , Ba Trung Nguyen MD , Celine Dan-Tam Nguyen BA , Negin Yavari MD , Azadeh Mobasserian MD , Irmak Karaca MD , S. Saeed Mohammadi MD , Ankur Sudhir Gupta MD , Chi Mong Christopher Or MD , Amir Akhavanrezayat MD , Cigdem Yasar MD , Aim-on Saengsirinavin MD , Ngoc Trong Tuong Than MD , Frances Andrea Anover MD , Osama Elaraby MD , Dalia El Feky MD , Woong-Sun Yoo MD, PhD , Xiaoyan Zhang MD, PhD , Quan Dong Nguyen MD, MSc
{"title":"Inherited retinal disease-associated uveitis","authors":"Jia-Horung Hung MD , Tanya Jain MD , Anadi Khatri MD , Ba Trung Nguyen MD , Celine Dan-Tam Nguyen BA , Negin Yavari MD , Azadeh Mobasserian MD , Irmak Karaca MD , S. Saeed Mohammadi MD , Ankur Sudhir Gupta MD , Chi Mong Christopher Or MD , Amir Akhavanrezayat MD , Cigdem Yasar MD , Aim-on Saengsirinavin MD , Ngoc Trong Tuong Than MD , Frances Andrea Anover MD , Osama Elaraby MD , Dalia El Feky MD , Woong-Sun Yoo MD, PhD , Xiaoyan Zhang MD, PhD , Quan Dong Nguyen MD, MSc","doi":"10.1016/j.survophthal.2025.03.011","DOIUrl":"10.1016/j.survophthal.2025.03.011","url":null,"abstract":"<div><div>Inherited retinal diseases (IRDs) are genetic disorders characterized by progressive photoreceptor function loss, often leading to significant visual impairment. Uveitis has been increasingly recognized in the clinical course of some IRDs. Despite advances in understanding the genetic causes and pathophysiology of IRDs, gaps remain in understanding the roles of inflammation and autoimmunity in IRD and IRD-associated uveitis. This review discusses IRD-associated uveitis, including anterior, intermediate, posterior, and panuveitis, as well as complications such as cystoid macular edema and retinal vasculitis. In patients with IRD-associated uveitis, mutations affecting protein function in cilia or photoreceptor outer segments suggest a universal autoimmune mechanism triggered by the immunogenicity of shedding photoreceptor discs. Notably, in patients where uveitis is the initial sign, CRB1 mutations are often implicated, likely due to the compromised blood-retina barrier function or alterations in the external limiting membrane. Other mechanisms leading to uveitis preceding IRD diagnosis include ALPK1 mutations, which activate the proinflammatory NF-κB pathway, CAPN5 mutations, which lead to dysfunction of the innate and adaptive immune systems, and VCAN1 mutations, which elicit immunogenicity due to irregularities in vitreous modeling. Understanding these mechanisms could enhance the development of innovative treatments that target personalized inflammation pathways in IRDs.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 951-981"},"PeriodicalIF":5.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The spectrum of microcystic macular edema: Pathogenetic insights, clinical entities, and functional prognosis","authors":"Matteo Mario Carlà MD, FEBO , Matteo Ripa MD, FEBO , Emanuele Crincoli MD, FEBO , Fiammetta Catania MD, FEBO , Stanislao Rizzo MD","doi":"10.1016/j.survophthal.2025.03.010","DOIUrl":"10.1016/j.survophthal.2025.03.010","url":null,"abstract":"<div><div>Microcystic macular edema (MME) is the presence of small cystoid abnormalities localized in the inner nuclear layer of the retina. First identified in the context of multiple sclerosis, successive reports highlighted the presence of microcystic changes in several optic nerve conditions, such as neuromyelitis optica, optic atrophy from several etiologies, medical retinal diseases such as age-related macular degeneration and diabetic retinopathy, and in the postoperative period after epiretinal membrane peeling. Generally, these cysts are not associated with vascular leakage, unlike the more conventional types of macular edema from vascular origin. A number of theories have been proposed to explain these findings: the suspect of neuronal loss as causative finding made the hypothesis of retrograde trans-synaptic degeneration likely, more recently flanked by theories including the presence of vitreomacular traction and Müller cells dysfunction. We gather all the insights regarding the pathogenesis, epidemiology and functional impact of MME.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 982-994"},"PeriodicalIF":5.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayushi Agarwal M.D., Vijitha S. Vempuluru M.D., Swathi Kaliki M.D.
{"title":"Primary ocular, adnexal, and orbital rhabdomyosarcoma: A review","authors":"Ayushi Agarwal M.D., Vijitha S. Vempuluru M.D., Swathi Kaliki M.D.","doi":"10.1016/j.survophthal.2025.03.009","DOIUrl":"10.1016/j.survophthal.2025.03.009","url":null,"abstract":"<div><div>We review the primary orbital, ocular, and adnexal rhabdomyosarcoma (RMS) spectrum of tumors and describe its clinicoradiological and histopathological features, molecular updates, management protocols, outcomes, and challenges. Despite being a favorable site, the prognosis remains dismal for cases of relapsing, refractory, and metastatic orbital RMS. A wide heterogeneity of data exists in terms of survival rates and treatment regimens spread across various geographic locations and age groups. Molecular cytogenetics is a crucial factor in both the diagnosis and effective management of RMS. Novel targeted therapy may play an integral role in avoiding treatment-related morbidity and mortality. Large-scale studies are warranted to formulate standardized regimens and uniformity, especially for advanced and metastatic cases.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 868-881"},"PeriodicalIF":5.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glaucoma in retinopathy of prematurity: A review","authors":"Nawazish Shaikh MD , Devesh Kumawat MD , Parijat Chandra MD , Sirisha Senthil MS , Andreas Stahl MD , Shikha Gupta MD , Viney Gupta MD","doi":"10.1016/j.survophthal.2025.03.006","DOIUrl":"10.1016/j.survophthal.2025.03.006","url":null,"abstract":"<div><div>Glaucoma in retinopathy of prematurity (ROP) is a challenge. It is typically secondary, though it may be associated with primary congenital glaucoma. Secondary causes are multifactorial, with mechanisms and severity potentially linked to the stage of ROP, time of presentation, or interventions for its treatment. Anecdotal reports of glaucoma following anti-vascular endothelial growth factor injection exist, but conclusive evidence is lacking. The most important cause of glaucoma in ROP is secondary angle closure in patients with stage 5 ROP. Clinical features such as corneal clouding and increased corneal diameters are clues to diagnosing glaucoma; however, glaucoma may present much later in life as well, therefore, life-long follow-up of these patients is essential. Appropriate control of intraocular pressure (IOP) becomes imperative in infants with ROP as these eyes tend to enlarge quickly with raised IOP. Management strategies consist of medical therapy, angle-based surgery, filtration surgery, glaucoma drainage devices and cyclo-ablation. The choice of therapy is individualized according to the age, presentation of glaucoma, and visual potential. We review the epidemiology, etiology, natural history, risk factors, clinical features, investigations, differential diagnosis, management and outcomes of glaucoma in ROP.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 930-941"},"PeriodicalIF":5.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arthur J. Sit SM, MD , Makoto Aihara MD, PhD , Anthony P. Khawaja PhD, FRCOphth , Shan C. Lin MD , Kaweh Mansouri MD, MPH , Atsuya Miki MD, PhD , Ki Ho Park MD, PhD , Norbert Pfeiffer MD, PhD , Robert N. Weinreb MD
{"title":"Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors","authors":"Arthur J. Sit SM, MD , Makoto Aihara MD, PhD , Anthony P. Khawaja PhD, FRCOphth , Shan C. Lin MD , Kaweh Mansouri MD, MPH , Atsuya Miki MD, PhD , Ki Ho Park MD, PhD , Norbert Pfeiffer MD, PhD , Robert N. Weinreb MD","doi":"10.1016/j.survophthal.2025.03.003","DOIUrl":"10.1016/j.survophthal.2025.03.003","url":null,"abstract":"<div><div>There has been limited success in both measuring and modifying episcleral venous pressure (EVP) in clinical practice. Understanding the potential role of EVP in the management of glaucoma for different patients may allow for more individualized treatment approaches. To explore the clinical implications of lowering EVP, an international group of 9 glaucoma experts (the ENGAGE Global Expert Working Group) convened to bridge the gap between the current literature and evidence with clinical opinion and best practices. This review summarizes insights from the group on the effect of current medical therapies on EVP and its potential impact. It also discusses unmet investigational needs to enhance the understanding of EVP, as well as the challenges associated with the measurement and treatment of EVP. Regardless of the relatively modest EVP reductions achieved with current treatments, EVP lowering may have clinical significance in patients with glaucoma, particularly those with low intraocular pressure (IOP). Those who might benefit include patients with elevated EVP; normal-tension glaucoma; undergoing trabecular meshwork bypass surgery, goniotomy, or selective laser trabeculoplasty; or requiring additional IOP lowering to the low teens or with a lower-than-usual target IOP.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 918-929"},"PeriodicalIF":5.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony Yao , Ahsen Hussain , Ruben Kannan , Charles Nduka , Raman Malhotra
{"title":"Dynamic procedures for eyelid involvement in facial nerve palsy","authors":"Anthony Yao , Ahsen Hussain , Ruben Kannan , Charles Nduka , Raman Malhotra","doi":"10.1016/j.survophthal.2025.03.002","DOIUrl":"10.1016/j.survophthal.2025.03.002","url":null,"abstract":"<div><div>Dynamic reconstructive techniques of the eyelid in facial nerve palsy aim to restore or replace spontaneous and voluntary movement. These may include transfer and graft techniques of nerve and muscle. The role of these procedures from an ophthalmic and oculoplastic perspective is yet to be established. We conducted a literature review of studies of periocular dynamic reanimation and their methodology, and the findings were critically appraised. Common weaknesses were identified, such as a lack of robust assessment of the ocular surface, failure to differentiate effortful closure from spontaneous blink, and inability to control for potential confounding variables.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 1013-1018"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}