Survey of ophthalmology最新文献

{"title":"Prevention of rhegmatogenous retinal detachment","authors":"Argyrios Chronopoulos MD,&nbsp;James S. Schutz MD,&nbsp;Robert P. Finger MD, PhD","doi":"10.1016/j.survophthal.2025.04.006","DOIUrl":"10.1016/j.survophthal.2025.04.006","url":null,"abstract":"<div><div>Rhegmatogenous retinal detachment (RRD) is a potentially blinding separation of neurosensory retina from retinal pigment epithelium by fluid passing from the vitreous cavity into the subretinal space through one or more retinal breaks, holes or tears. Although most RRDs can be repaired surgically with one operation, some visual loss often results, especially if the macula has been detached, and a small fraction of RRDs require multiple surgeries with significant morbidity, including permanent severe visual loss. Vitrectomy, the most popular RRD surgery, is associated with temporary visual loss and postoperative positioning with limited activity for 1 or 2 weeks; phakic patients usually require cataract surgery within 2 years. Consequently, RRD prevention would be ideal, achieved by early accurate diagnosis of retinal tears and prophylactic outpatient retinopexy, easy, highly successful in sealing retinal breaks and usually uncomplicated. The interval between retinal tears and detachment of the retina is often long enough for laser retinopexy; however, the importance of retinal tear symptoms and prompt evaluation is not well known by the public nor nonophthalmic medical providers, causing a delay that prevents retinopexy and results in surgical repair. New educational programs are needed. Most RRDs are idiopathic but traumatic RRDs also can be avoided by protective eye wear in hazardous sports and occupations and also timely eye examination and retinopexy. Suggestions for improved retinal tear diagnosis are offered.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1061-1066"},"PeriodicalIF":5.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of retinal vasculitis: A systematic review and meta‐analysis from the International Uveitis Study Group (IUSG) Retinal Vasculitis Study (ReViSe) Report 3","authors":"Carlos Cifuentes-González ,&nbsp;Yong Le Tong ,&nbsp;William Rojas-Carabali ,&nbsp;Germán Mejía-Salgado ,&nbsp;Ikhwanuliman Putera ,&nbsp;Xin Ying Rachel Song ,&nbsp;Cheong Fu Yuan Walter ,&nbsp;Zhang Shengjuan ,&nbsp;Reo Chan ,&nbsp;Azadeh Mobasserian ,&nbsp;Rina La Distia Nora ,&nbsp;Jyotirmay Biswas ,&nbsp;Sapna Gangaputra ,&nbsp;Jose S. Pulido ,&nbsp;John H. Kempen ,&nbsp;Quan Dong Nguyen ,&nbsp;Alejandra de la Torre ,&nbsp;Vishali Gupta ,&nbsp;James T. Rosenbaum ,&nbsp;Rupesh Agrawal ,&nbsp;Uwe Pleyer","doi":"10.1016/j.survophthal.2025.04.001","DOIUrl":"10.1016/j.survophthal.2025.04.001","url":null,"abstract":"<div><div><span><span>We investigate the clinical characteristics and complications of retinal vasculitis (RV), categorizing cases into Secondary RV (associated with systemic disease), Syndromic RV (linked to ocular syndromes without systemic disease), Idiopathic RV (without </span>systemic disease or ocular syndrome diagnoses), and Multiple Etiology RV (cohorts of retinal vasculitis with more than one subcategories of the above). A systematic search was conducted on June 14, 2023, across PubMed, Embase, Cochrane (Ovid), VHL, and ProQuest databases, following PRISMA guidelines (PROSPERO registration: CRD42023489232). Out of 5533 screened articles, 97 studies involving 7619 patients with RV met the eligibility criteria. Bilateral involvement (64 %) and reduced vision (52 %) were common across all RV categories, with Idiopathic RV showing the highest rates of bilateral involvement (80 %) and </span>vision loss<span><span> (79 %). Syndromic RV was characterized by retinal ischemia<span> (76 %) and vitreous hemorrhage (46 %), while Secondary RV exhibited higher incidences of </span></span>cystoid macular edema<span> (32 %) and neovascular glaucoma (24 %). Geographic variations were evident in Multiple Etiology RV, with inflammation in more than 1 intraocular structure more prevalent in Asia (64 %) than in Europe (29 %). These findings highlight the heterogeneity in RV presentation and complications, illustrating the need for standardized diagnostic criteria and improved clinical reporting to enable better classification, treatment strategies, and patient outcomes.</span></span></div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1144-1159"},"PeriodicalIF":5.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomic biomarkers as potential endpoints in diabetic macular edema: A systematic literature review with identification of macular volume as a key surrogate for visual acuity","authors":"Aude Couturier ,&nbsp;Charles C. Wykoff ,&nbsp;Marco Lupidi ,&nbsp;Patricia Udaondo ,&nbsp;Tunde Peto ,&nbsp;Pierre-Jean Pintard","doi":"10.1016/j.survophthal.2025.04.004","DOIUrl":"10.1016/j.survophthal.2025.04.004","url":null,"abstract":"<div><div>Optimization of diabetic macular edema (DME) treatment pathways can aid in the efficient introduction of new therapies that provide value to patients and healthcare systems. We performed a systematic literature review and multicorrelation analysis to identify and evaluate anatomic biomarkers as potential surrogate endpoints (SEs) for visual acuity (VA) in patients with DME. We performed EMBASE and MEDLINE searches to identify studies reporting on 4 priority biomarkers previously identified by clinical experts: hyperreflective foci, intraretinal cyst, macular volume (MV), and subretinal fluid. Endpoint and treatment effect correlation analyses were performed to establish correlation coefficients between MV and VA using Pearson’s correlation. A total of 105 studies reported change from baseline data for VA, and at least 1 biomarker, with MV investigated most often (n = 70 studies). Data extracted from 55 studies focusing on the 6-mm zone for MV were used in statistical analyses. A moderate correlation was observed between MV and VA at the endpoint level (r = 0.58; <em>p</em> &lt; 0.01); however, a corresponding treatment effect was not found (r = 0.32; <em>p</em> = 0.19). Our findings suggest MV's potential as an SE for VA in future clinical practice; however, the lack of a significant treatment effect warrants that these findings be interpreted cautiously. Further evidence and improvements in reporting the methods for collecting biomarker data are needed. Analysis of outliers and subanalyses by other optical coherence tomography measures could establish the most meaningful MV values correlating with VA.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1090-1110"},"PeriodicalIF":5.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The advancements in precision medicine for Leber congenital amaurosis: Breakthroughs from genetic diagnosis to therapy","authors":"Pei Zhang,&nbsp;Zhuping Xu","doi":"10.1016/j.survophthal.2025.04.005","DOIUrl":"10.1016/j.survophthal.2025.04.005","url":null,"abstract":"<div><div><span>Leber congenital amaurosis<span><span><span> (LCA) is a hereditary retinal disease typically manifesting as severe </span>vision impairment<span><span><span> in infancy. With the advancement of precision medicine, genetic diagnosis and targeted therapies offer new </span>hope<span> for LCA patients, significantly improving both diagnostic accuracy and therapeutic efficacy. We summarize the epidemiological characteristics, clinical manifestations, and molecular genetics underlying LCA. We also highlight recent developments in precision treatment strategies, including </span></span>gene replacement therapy, CRISPR/Cas9-mediated gene editing and </span></span>antisense oligonucleotide therapies. In addition, we discuss the applications of </span></span>induced pluripotent stem cells<span><span> and retinal organoids in LCA treatment research. Furthermore, we explore preventive strategies and future treatment directions for LCA, including the development of novel gene therapy vectors, the optimization of combinatorial treatment strategies, and the formulation of personalized treatment approaches. These advancements hold significant potential to offer improved treatment options and enhance the </span>quality of life for LCA patients.</span></div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1205-1219"},"PeriodicalIF":5.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of rho kinase inhibitors in ophthalmology: From mechanisms to clinical practice","authors":"Jit Kai Tan ,&nbsp;David H. Steel ,&nbsp;Sajjad Ahmad ,&nbsp;Ananth Viswanathan ,&nbsp;Rashmi G. Mathew ,&nbsp;Peng Tee Khaw ,&nbsp;Christin Henein","doi":"10.1016/j.survophthal.2025.03.008","DOIUrl":"10.1016/j.survophthal.2025.03.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The therapeutic potential of rho kinase (ROCK) inhibitors in ophthalmology is gaining attention, given their multifaceted role in cellular regulation, particularly within ocular pathologies. This review synthesizes findings from clinical and preclinical studies on the efficacy and safety of ROCK inhibitors across glaucoma, corneal, and retinal diseases. We performed a systematic database search in Ovid MEDLINE and Ovid Embase on 5th April 2022 using the following keywords: ‘primary open angle glaucoma’, ‘glaucoma surgery’, ‘corneal wound healing’, ‘corneal endothelial dysfunction’, ‘diabetic retinopathy’, ‘diabetic macular oedema’, ‘age-related macular degeneration’, ‘rho kinase inhibitor’, ‘rho-kinase inhibitor’, rock inhibitor’, ‘ripasudil’, ‘netarsudil’ and ‘fasudil’. Abstracts were screened for relevant studies and results summarized in tables. The analysis of trials done for ROCK inhibitors reveals that they are safe and efficacious drugs, demonstrating noninferiority to existing medical treatments and effective when combined with existing treatments, and are approved for use in treating glaucoma, but not corneal or retinal diseases. Questions remain, however, regarding optimal dosage, patient selection, and cost-effectiveness. ROCK inhibitors demonstrate significant efficacy in reducing intraocular pressure by improving aqueous humour outflow. Additionally, ROCK inhibitors show promise in enhancing endothelial cell migration, thus providing a novel treatment avenue for corneal diseases such as Fuchs endothelial dystrophy. In retinal conditions, including diabetic retinopathy and age-related macular degeneration, ROCK inhibitors reduce vascular permeability, inflammation, and fibrosis, stabilising disease progression.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 900-917"},"PeriodicalIF":5.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of medications on the human electroretinogram: A comprehensive review","authors":"Justin J. Grassmeyer ,&nbsp;Mark E. Pennesi ,&nbsp;Paul Yang ,&nbsp;Wayne Tschetter ,&nbsp;Lesley A. Everett","doi":"10.1016/j.survophthal.2025.04.003","DOIUrl":"10.1016/j.survophthal.2025.04.003","url":null,"abstract":"<div><div>The electroretinogram (ERG) is a well-established method to investigate retinal function and can often provide critical diagnostic information for underlying retinal disorders<span>. ERG responses rely on the neuronal activity<span> of retinal cells which, like neurons elsewhere, are subject to perturbation by a wide spectrum of neuromodulating substances. These agents have the potential to confound electrophysiologic recordings used to evaluate visual function. We provide a comprehensive literature review of studies that have examined the impact of pharmacologic agents on human electrophysiologic testing of retinal function. This review is focused primarily on full-field ERG data, but also includes a limited number of studies examining effects of medications on pattern ERG and visual evoked potential recordings. The studies reviewed are categorized by medication class and evidence level according to the strength of the supporting data; for example, some included studies have a lower evidence level because they included a small number of subjects or did not use international electrophysiology testing standards. We identified numerous widely-used medications and some recreational substances that have been shown to alter ERG responses, underscoring the need to take a complete medical and medication history for each patient undergoing ERG testing.</span></span></div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1230-1251"},"PeriodicalIF":5.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical manifestations of cytomegalovirus infection in patients with Posner-Schlossman syndrome: A systematic review and meta-analysis","authors":"Ssu-Hsien Lee MD ,&nbsp;Yan-Rong Ho MD ,&nbsp;Hua Li PhD ,&nbsp;Yu-Kang Tu PhD ,&nbsp;Katelyn Bowman MS4 ,&nbsp;Eric H. Chou MD ,&nbsp;Yuan-Chieh Lee MD PhD ,&nbsp;Hou-Ren Tsai MD ,&nbsp;Tou-Yuan Tsai MD","doi":"10.1016/j.survophthal.2025.04.002","DOIUrl":"10.1016/j.survophthal.2025.04.002","url":null,"abstract":"<div><div><span><span>Posner-Schlossman syndrome (PSS) is thought to be associated with cytomegalovirus (CMV) infection; however, the prevalence of CMV<span> infection and its characteristics in PSS patients varies across studies. Therefore, global estimates of CMV prevalence in PSS are needed to provide clearer insights for informing </span></span>epidemiological surveillance<span><span> and guiding treatment strategies. Embase, MEDLINE, Scopus, and Web of Science were searched for population-based, clinic-based, and secondary health care database studies that reported prevalence or incidence of CMV in patient with PSS published between database inception and October 31, 2024. Meta-analysis was conducted by using a random-effects model. The primary outcome was prevalence of CMV infection in patient with PSS. Secondary outcomes were characteristics of CMV infection in patient with PSS, such as corneal </span>endothelial cell density and filtering surgery rate. Twenty-one studies, enrolling 1265 patients with PSS, were included. The pooled prevalence of CMV infection in patients with PSS was 44.5 % (95 % CI: 36.2 %–53.1 %; </span></span><em>I</em>²= 73.9 %). The affected eye in patients with CMV infection had significantly lower endothelial density (mean difference, −389.8 cell/mm²; 95 % CI: −553.8 to −225.9 cell/mm²; <em>p</em> &lt; 0.001; <em>I</em> ² = 53.8 %) and a higher risk of requiring filtration surgery than that in patients without CMV infection (pooled OR: 8.9, 95 % CI: 3.0–26.4; <em>p</em> &lt; 0.001; <em>I</em> ² = 0 %). We highlight the prevalence and clinical outcomes of CMV infection in patients with PSS. The causal relationship between CMV infection and PSS requires exploration to inform effective diagnosis and treatment strategies.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1252-1260"},"PeriodicalIF":5.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"The applications of viscoelastic agents in vitreoretinal surgery\"","authors":"Fikret Ucar","doi":"10.1016/j.survophthal.2025.03.015","DOIUrl":"10.1016/j.survophthal.2025.03.015","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 6","pages":"Pages 1269-1270"},"PeriodicalIF":5.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Comment on: \"The applications of viscoelastic agents in vitreoretinal surgery\".","authors":"Matteo Mario Carlà","doi":"10.1016/j.survophthal.2025.03.014","DOIUrl":"10.1016/j.survophthal.2025.03.014","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to correspondence.","authors":"Ken Nagino, Takenori Inomata, Toshihiko Ohta, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Gaku Ishida, Keiji Inagaki, Masahiro Yamaguchi, Satoru Nakatani, Kenta Fujio, Hiroyuki Kobayashi, Shintaro Nakao","doi":"10.1016/j.survophthal.2025.03.013","DOIUrl":"10.1016/j.survophthal.2025.03.013","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}