Survey of ophthalmology最新文献

{"title":"Clinical utilization of microperimetry in ophthalmic surgery: A narrative review","authors":"Timothy Kalas ,&nbsp;Alexander Newman ,&nbsp;Jonathan Whyte ,&nbsp;Abhishek Sharma","doi":"10.1016/j.survophthal.2023.10.011","DOIUrl":"10.1016/j.survophthal.2023.10.011","url":null,"abstract":"<div><p><span>Microperimetry is an emerging technology that provides concurrent analysis of retinal structure and function by combining retinal sensitivity and fixation analysis with fundus imaging<span>. We summarize the substantial evidence validating the evolving role of microperimetry as an adjunctive assessment of visual function in the perioperative setting. We show that microperimetry provides useful complementary information to other established imaging and functional modalities in the perioperative setting for a wide range of vitreoretinal surgical procedures, as well as in cataract and refractive surgeries. This includes preoperative uses such as prognostication of visual and anatomical outcomes, timing of surgical intervention, and assessment of patient suitability for surgery–as well as postoperative uses including quantification of visual recovery, investigation of unexplained postoperative </span></span>vision loss, and informing expected long term functional outcomes.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of smartphone funduscopy for diabetic retinopathy screening","authors":"Neil Vaughan PhD, RFREng, FHEA, MSc, BSc","doi":"10.1016/j.survophthal.2023.10.006","DOIUrl":"10.1016/j.survophthal.2023.10.006","url":null,"abstract":"<div><p>I detail advances in funduscopy diagnostic systems integrating smartphones. Smartphone funduscopy devices are comprised of lens devices connecting with smartphones and software applications to be used for mobile retinal image capturing and diagnosis of diabetic retinopathy. This is particularly beneficial to automate and mobilize retinopathy screening techniques and methods in remote and rural areas as those diabetes patients are often not meeting the required regular screening for diabetic retinopathy. Smartphone retinal image grading systems enable retinopathy to be screened remotely as teleophthalmology or as a stand-alone point-of-care-testing system. Smartphone funduscopy aims to avoid the need for patients to be seen by expert ophthalmologists, which can reduce patient travel, time taken for images to be processed, appointment backlog, health service overhead costs, and the workload burden for expert ophthalmologists.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625723001327/pdfft?md5=37d429bd484bf40146218e217887aca1&pid=1-s2.0-S0039625723001327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41130173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of intravitreal anti-vascular endothelial growth factor injection in peripheral exudative hemorrhagic chorioretinopathy: A systematic review","authors":"Akash Gowda MBBS ,&nbsp;Bobak Bahrami MBBS, PhD ,&nbsp;Wilson Wong Jun Jie MD, FRCOphth ,&nbsp;Robert Casson MBBS (Hons), M. Biostatistics, DPhil, FRANZCO ,&nbsp;Weng Onn Chan MBChB, MPhil, FRANZCO","doi":"10.1016/j.survophthal.2023.10.004","DOIUrl":"10.1016/j.survophthal.2023.10.004","url":null,"abstract":"<div><p>Anti‐vascular endothelial growth factor (anti-VEGF) injections have revolutionized the field of ophthalmology, and their use in a variety of retinal diseases is growing. One target disease is peripheral exudative hemorrhagic chorioretinopathy, a disease that is uncommon and poorly understood. Despite this, there are numerous studies and case reports outlining the potential role of intravitreal injection of anti-VEGF medicines to treat it. As such, an evidence-based understanding of its risk-benefit profile is vital. We performed a comprehensive search in the PubMed, Google Scholar, and Cochrane databases for published studies and case reports relating to the use of anti-VEGF injections in peripheral exudative hemorrhagic chorioretinopathy. Anti-VEGF was first used in 2010 to aid in the management of peripheral exudative hemorrhagic chorioretinopathy. Since then, it has been increasingly used to manage this disease. Other potential management strategies, including laser photocoagulation, cryotherapy, photodynamic therapy, and vitrectomy are explored and compared with anti-VEGF where possible. Anti-VEGF appears to be an effective therapy in managing peripheral exudative hemorrhagic chorioretinopathy, especially when there is an exudative threat to the macula.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625723001315/pdfft?md5=79173a0fef752cb7d5cbab3509fdf70d&pid=1-s2.0-S0039625723001315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior chamber inflammation grading methods: A critical review","authors":"Hnin Hnin Oo Mmed ,&nbsp;Madhuvanthi Mohan MS ,&nbsp;Wenjun Song Mmed ,&nbsp;William Rojas-Carabali MD ,&nbsp;Edmund Tsui MD ,&nbsp;Alejandra de-la-Torre MD, PhD ,&nbsp;Carlos Cifuentes-González MD ,&nbsp;Andres Rousselot MD ,&nbsp;Sangly P. Srinivas PhD ,&nbsp;Tariq Aslam PhD ,&nbsp;Vishali Gupta MD ,&nbsp;Rupesh Agrawal FRCS","doi":"10.1016/j.survophthal.2023.10.005","DOIUrl":"10.1016/j.survophthal.2023.10.005","url":null,"abstract":"<div><p><span>Assessing anterior chamber inflammation is highly subjective and challenging. Although various grading systems attempt to offer objectivity and standardization, the clinical assessment has high interobserver variability. Traditional techniques, such as laser flare meter and </span>fluorophotometry<span>, are not widely used since they are time-consuming. With the development of optical coherence tomography with high sensitivity, direct imaging offers an excellent alternative to assess objectively inflammation with the potential for automated analysis. We describe various anterior chamber inflammation grading methods and discuss their utility, advantages, and disadvantages.</span></p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41150041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Observations on the association between obstructive sleep apnea and floppy eyelid syndrome: A systematic review and meta-analysis”","authors":"Alex Jia Yang Cheong MBBS,&nbsp;Owen Tsung Wen Ho MBBS,&nbsp;Sean Kang Xuan Wang MBBS,&nbsp;Chang Yi Woon MBBS,&nbsp;Anna See MPH,&nbsp;Adele Chin Wei Ng MMED (ORL),&nbsp;Shaun Ray Han Loh MMED (ORL),&nbsp;Soon-Phaik Chee FRCOphth,&nbsp;Song Tar Toh FAMS (ORL)","doi":"10.1016/j.survophthal.2023.10.003","DOIUrl":"10.1016/j.survophthal.2023.10.003","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual conjunctival melanocytic proliferations. Report of five cases and review of the literature","authors":"Adrianna Eder ,&nbsp;Tatyana Milman ,&nbsp;Hardeep-Singh Mudhar ,&nbsp;Sara E. Lally ,&nbsp;Carol L. Shields ,&nbsp;Khanh Bui ,&nbsp;Jill R. Wells ,&nbsp;Hans E. Grossniklaus","doi":"10.1016/j.survophthal.2023.10.012","DOIUrl":"10.1016/j.survophthal.2023.10.012","url":null,"abstract":"<div><p><span>Indeterminate melanocytic proliferations of the conjunctiva have both benign and malignant features that previously made these lesions nearly impossible to categorize in existing classification schemes. With the evolution of </span>immunohistochemistry<span><span><span> and molecular genetics, however, subclassifications have emerged that allow for a more tailored diagnosis and management. These conjunctival melanocytic proliferations include deep penetrating nevus, </span>granular cell nevus, and nevoid </span>melanoma<span>. There remains a small subset of conjunctival melanocytic proliferations that defy precise characterization as nevi, primary acquired melanosis, or melanomas despite currently available ancillary diagnostic modalities and remain indeterminate. We highlight these unusual types of nevi and melanomas, with an update on their morphologic, immunohistochemical, and molecular genetic characteristics.</span></span></p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61565382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal organoids in disease modeling and drug discovery: Opportunities and challenges","authors":"Koushik Chakrabarty PhD ,&nbsp;Divyani Nayak MSc ,&nbsp;Jayasree Debnath MTech ,&nbsp;Debashish Das PhD ,&nbsp;Rohit Shetty DNB, FRCS, PhD ,&nbsp;Arkasubhra Ghosh PhD","doi":"10.1016/j.survophthal.2023.09.003","DOIUrl":"10.1016/j.survophthal.2023.09.003","url":null,"abstract":"<div><p><span><span>Diseases leading to retinal cell loss can cause severe visual impairment<span> and blindness<span><span>. The lack of effective therapies<span> to address retinal cell loss and the absence of intrinsic regeneration in the human retina leads to an irreversible pathological condition. Progress in recent years in the generation of human three-dimensional retinal organoids from </span></span>pluripotent stem cells<span><span> makes it possible to recreate the cytoarchitecture and associated cell-cell interactions of the human retina in remarkable detail. These human three-dimensional retinal organoid systems made of distinct retinal cell types and possessing contextual </span>physiological responses allow the study of human </span></span></span></span>retina development and </span>retinal disease<span> pathology in a way animal model and two-dimensional cell cultures were unable to achieve. We describe the derivation of retinal organoids from human pluripotent stem cells and their application for modeling retinal disease pathologies, while outlining the opportunities and challenges for its application in academia and industry.</span></p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and anesthetic influences of the oculocardiac reflex in adults and children during strabismus surgery","authors":"Shira L. Robbins MD, FAAO, FAAP,&nbsp;Mark Greenberg MD,&nbsp;Ilona Juan MD","doi":"10.1016/j.survophthal.2023.06.006","DOIUrl":"10.1016/j.survophthal.2023.06.006","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In praise of povidone-iodine application in ophthalmology","authors":"Mohammad Soleimani ,&nbsp;Ali A. Haydar ,&nbsp;Kasra Cheraqpour ,&nbsp;Haniyeh Zeidabadinejad ,&nbsp;Amirreza Esfandiari ,&nbsp;Niloofarsadaat Eshaghhosseiny ,&nbsp;Alireza Shahmohammadi ,&nbsp;Soraya Banz ,&nbsp;Ali R. Djalilian","doi":"10.1016/j.survophthal.2023.11.002","DOIUrl":"10.1016/j.survophthal.2023.11.002","url":null,"abstract":"<div><p><span><span><span>Polyvinyl pyrrolidone or povidone-iodine (PVP-I) is a water-soluble complex formed by the combination of iodine and a water-soluble polymer, polyvinyl pyrrolidone. This complex exerts bactericidal, fungicidal, and virucidal action by gradually releasing free iodine at the site of application to react with </span>pathogens<span><span>. In ophthalmology, PVP-I is used as a disinfectant and antiseptic agent for preoperative preparation of the skin and </span>mucous membranes and for treating contaminated wounds. PVP-I has been shown to reduce effectively the risk of </span></span>endophthalmitis<span><span> in various ocular procedures, including cataract surgery<span> and intravitreal injections<span>; however, it has also been used in the treatment of </span></span></span>conjunctivitis<span>, keratitis, and endophthalmitis, with promising results especially in low-resource situations. PVP-I has been associated with complications such as postoperative eye pain, </span></span></span>persistent corneal epithelial defects<span>, ocular inflammation, and an attendant risk of keratitis. In cases of poor PVP-I tolerance, applying PVP-I at lower concentrations or using alternative antiseptics such as chlorhexidine should be considered. We provide an update on the efficacy of PVP-I in the prophylaxis and treatment of conjunctivitis, keratitis, and endophthalmitis and a comprehensive analysis of the current literature regarding the use of PVP-I in the management of these ocular conditions. Also, PVP-I-related adverse effects and toxicities and its alternatives are discussed. The goal is to present a thorough evaluation of the available evidence and to offer practical recommendations for clinicians regarding the therapeutic usage of PVP-I in ophthalmology.</span></p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of different agents and doses of anti-vascular endothelial growth factors (aflibercept, bevacizumab, conbercept, ranibizumab) versus laser for retinopathy of prematurity: A network meta-analysis","authors":"Amparo Ortiz-Seller ,&nbsp;Pablo Martorell ,&nbsp;Honorio Barranco ,&nbsp;Isabel Pascual-Camps ,&nbsp;Esteban Morcillo ,&nbsp;José L. Ortiz","doi":"10.1016/j.survophthal.2024.02.005","DOIUrl":"10.1016/j.survophthal.2024.02.005","url":null,"abstract":"<div><p>Laser photocoagulation (LPC) and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections constitute the current standard treatment for retinopathy of prematurity (ROP). This network meta-analysis focus on whether a ranking of interventions may be established for different dose levels of intravitreal injection of anti-VEGF agents (aflibercept, bevacizumab, conbercept, ranibizumab) as primary treatments for ROP versus laser in terms of retreatment rate as primary outcome, and time to retreatment and refractive error as secondary endpoints, since best anti-VEGF dosage remains under debate. Sixty-eight studies (15 randomized control trials and 53 nonrandomized studies) of 12,356 eyes of 6445 infants were retrieved from databases (2005 Jan. – 2023 June). Studies were evaluated for model fit, risk of bias and confidence of evidence in Network Meta-Analysis (CINeMA). Bayesian NMA showed that anti-VEGF drugs were not inferior to laser in terms of retreatment rate. For intravitreal bevacizumab (IVB), doses half of the conventional infant dose showed a low risk of retreatment rate (risk ratio (RR) of 1.43; 95% credible interval (CrI): 0.508, 4.03). On probability ranking as surface under the cumulative ranking curve (SUCRA) plot, half dose of bevacizumab had a better position than conventional and augmented (1.2–2 times the regular dose) doses. A similar probability trend was observed for half vs. conventional doses of aflibercept and ranibizumab. Conventional infant dose of conbercept showed the lowest risk for retreatment (RR 0.846; 95% CrI: 0.245, 2.91). For secondary endpoints, lower doses of anti-VEGF agents were associated with shorter times to retreatment. The largest changes were noted for the augmented doses of bevacizumab and ranibizumab (0.3 mg) with means of 14.1 weeks (95% CrI: 6.65, 21.6) and 12.8 weeks (95% CrI: 3.19, 20.9), respectively. Finally, NMA demonstrated better refractive profile for anti-VEGF than laser therapy, especially for the conventional infant doses of bevacizumab and ranibizumab which exhibited a significantly better refractive profile than LPC, with mean differences of 1.67 (spherical equivalent - diopters) (95% CrI: 0.705, 2.67) and 2.19 (95% CrI: 0.782, 3.59), respectively. In the SUCRA plots, LPC had a markedly different position with a higher probability for myopia. Further clinical trials comparing different intravitreal doses of anti-VEGF agents are needed, but our findings suggest that low doses of these drugs retain efficacy and may reduce ocular and systemic undesired events.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000080/pdfft?md5=96a537585eb5bf08df935655ddb125f2&pid=1-s2.0-S0039625724000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}