Anthony Yao , Ahsen Hussain , Ruben Kannan , Charles Nduka , Raman Malhotra
{"title":"Dynamic procedures for eyelid involvement in facial nerve palsy","authors":"Anthony Yao , Ahsen Hussain , Ruben Kannan , Charles Nduka , Raman Malhotra","doi":"10.1016/j.survophthal.2025.03.002","DOIUrl":"10.1016/j.survophthal.2025.03.002","url":null,"abstract":"<div><div>Dynamic reconstructive techniques of the eyelid in facial nerve palsy aim to restore or replace spontaneous and voluntary movement. These may include transfer and graft techniques of nerve and muscle. The role of these procedures from an ophthalmic and oculoplastic perspective is yet to be established. We conducted a literature review of studies of periocular dynamic reanimation and their methodology, and the findings were critically appraised. Common weaknesses were identified, such as a lack of robust assessment of the ocular surface, failure to differentiate effortful closure from spontaneous blink, and inability to control for potential confounding variables.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 1013-1018"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From anatomical and functional observations to molecular dynamics in internal limiting membrane peeling","authors":"Axel Petzold","doi":"10.1016/j.survophthal.2025.02.008","DOIUrl":"10.1016/j.survophthal.2025.02.008","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 4","pages":"Pages 845-846"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramsey Ghaleb BA , Ahmed B. Sallam MD, PhD , Florin Grigorian MD , Paul H. Phillips MD , Abdelrahman M. Elhusseiny MD, MSc
{"title":"Oral fluorescein angiography in pediatric ophthalmology","authors":"Ramsey Ghaleb BA , Ahmed B. Sallam MD, PhD , Florin Grigorian MD , Paul H. Phillips MD , Abdelrahman M. Elhusseiny MD, MSc","doi":"10.1016/j.survophthal.2025.03.005","DOIUrl":"10.1016/j.survophthal.2025.03.005","url":null,"abstract":"<div><div>We evaluate the administration protocols, diagnostic utility, and safety of oral fluorescein angiography (OFA) in pediatric ophthalmological diseases, with a secondary objective of comparing OFA to intravenous fluorescein angiography (IVFA) in terms of image quality and clinical utility. A comprehensive search of PubMed, Embase, and Web of Science was conducted, focusing on studies involving pediatric patients. Fifteen studies were included, with 11 assessing the utility and safety of OFA and 4 comparing it to IVFA. These studies covered 581 eyes from 464 patients. The most common dosing protocol for OFA involved 25 mg/kg of 10 % fluorescein dye, with various dilution solutions and fasting requirements enhancing image quality. Adverse effects were minimal, with mild reactions such as itching or nausea observed in 0.019 % of patients. OFA demonstrated good diagnostic value across various pathologies, including retinal vasculopathies, uveitis, disc edema, and Coats disease. OFA is a feasible imaging modality that is a less invasive and better-tolerated alternative to IVFA in the pediatric population, providing high-quality diagnostic images with fewer adverse effects. Our review highlights the need for standardized administration protocols and further research into optimizing dosing and ingestion techniques to enhance image quality and diagnostic utility.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 849-858"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration","authors":"Yingying Chen MD, Feipeng Jiang, Yue Zeng MD, Meixia Zhang MD","doi":"10.1016/j.survophthal.2025.03.004","DOIUrl":"10.1016/j.survophthal.2025.03.004","url":null,"abstract":"<div><div>Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aging population. Evidence showing the presence of cellular senescence in retinal pigment epithelium (RPE) of patients with AMD is growing. Senescent RPE play a pivotal role in its pathogenesis. The senescent RPE suffers from structural and functional alterations and disruption of the surrounding microenvironment due to the development of the senescence-associated secretory phenotype, which contributes to metabolic dysfunctions and inflammatory responses in the retina. Senotherapeutics, including senolytics, senomorphics and others, are novel treatments targeting senescent cells and are promising treatments for AMD. As senotherapeutic targets are being developed, it is promising that the burden of AMD could be decreased.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 942-950"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Rodriguez-Garcia MD , Raul E. Ruiz-Lozano MD , Raul H. Barcelo-Canton MD , Hector M. Marines-Sanchez MD , J. Homar Paez-Garza MD
{"title":"The etiologic and pathogenic spectrum of exposure keratopathy: Diagnostic and therapeutic implications","authors":"Alejandro Rodriguez-Garcia MD , Raul E. Ruiz-Lozano MD , Raul H. Barcelo-Canton MD , Hector M. Marines-Sanchez MD , J. Homar Paez-Garza MD","doi":"10.1016/j.survophthal.2025.03.001","DOIUrl":"10.1016/j.survophthal.2025.03.001","url":null,"abstract":"<div><div>Exposure keratopathy (EK) is an underestimated ocular surface disorder that involves multiple underlying pathophysiologic mechanisms. It results from an exposed cornea due to different causes of eyelid insufficiency or blinking dysfunction, ocular globe protrusion, a negative orbital vector, and diverse contributing factors leading to impaired ocular surface homeostasis and the potential for vision loss. EK can be congenital, acquired, or induced, and various risk factors predispose patients to corneal exposure. These causes can be grouped into those related to proptosis and eyelid malformations, malfunctioning, or acquired deformity.</div><div>If detected early, EK offers a range of effective treatment options. The superficial punctate keratitis and dryness of the cornea's lower third can be successfully treated at the initial stages; however, if left untreated, EK can progress to extensive epithelial erosion, persistent epithelial defects, stromal melting, vascularization, squamous metaplasia, and opportunistic infections, leading to significant visual loss. Different and varied treatment modalities, including medical and surgical, are available for patients with EK, depending on the disease stage, the underlying mechanism, and the cause.</div><div>We examine the risk factors, causes, and range of pathologies associated with EK. Exploring the mechanisms that contribute to the development of the disorder's clinical manifestations provides valuable insights that can help clinicians detect and diagnose the disease promptly and plan appropriate targeted treatments.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 882-899"},"PeriodicalIF":5.1,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor by Professor Axel Petzold","authors":"Elham Sadeghi, Jay Chhablani","doi":"10.1016/j.survophthal.2025.02.007","DOIUrl":"10.1016/j.survophthal.2025.02.007","url":null,"abstract":"","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 4","pages":"Page 847"},"PeriodicalIF":5.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaersti L. Rickels , Ramsey Ghaleb , Abdelrahman M. Elhusseiny , Muhammad Z. Chauhan , Joseph Toma , Tony Wang , Daniel Cheng , Asim Ali , Ahmed B. Sallam
{"title":"Ocular manifestations secondary to cocaine abuse","authors":"Kaersti L. Rickels , Ramsey Ghaleb , Abdelrahman M. Elhusseiny , Muhammad Z. Chauhan , Joseph Toma , Tony Wang , Daniel Cheng , Asim Ali , Ahmed B. Sallam","doi":"10.1016/j.survophthal.2025.02.004","DOIUrl":"10.1016/j.survophthal.2025.02.004","url":null,"abstract":"<div><div>Cocaine, a prevalent drug of abuse, is associated with numerous systemic health complications, including significant ocular manifestations. These ocular effects range from mild to severe, with the potential for irreversible vision loss. Despite the extensive documentation of cocaine's systemic effects, the literature still lacks a focused review of its ocular manifestations. We methodically explore the epidemiology, pathophysiology, clinical presentations, diagnostic challenges, and therapeutic approaches related to cocaine-associated ocular manifestations. By categorizing the findings based on the anatomical location and type of pathology—orbital, corneal, retinal, neuro-ophthalmic, glaucoma-related, and uveal manifestations—we aim to provide a detailed overview that aids in early diagnosis and effective management of ocular disease secondary to cocaine use. Our review highlights the importance of awareness among clinicians, showcasing the wide range of ocular pathology to improve patient outcomes and prevent long-term ocular damage after cocaine abuse.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 4","pages":"Pages 825-832"},"PeriodicalIF":5.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological agents for treatment of proliferative vitreoretinopathy: A systematic review and network meta-analysis","authors":"Sina Khosravi Mirzaei MD , Firouze Hatami MD , Sare Safi PhD , Zahra Khorrami PhD , Fatemeh Khosravi Shadmani PhD , Seyed Mohamadmehdi Moshtaghion MD , Hamid Ahmadieh MD","doi":"10.1016/j.survophthal.2025.02.005","DOIUrl":"10.1016/j.survophthal.2025.02.005","url":null,"abstract":"<div><div>We performed a comprehensive systematic review and network meta-analysis (NMA) to assess the efficacy of pharmacological agents for the treatment of proliferative vitreoretinopathy (PVR) following retinal detachment (RD) surgery. A systematic search was performed across PubMed, Scopus, Web of Science, and Embase. Randomized and non-randomized controlled trials and comparative observational studies evaluating the effect of pharmacological agents in a clinical setting were included. The primary outcome was retinal reattachment rate, and secondary outcomes were PVR recurrence, reoperation, intraocular pressure (IOP), epiretinal membrane (ERM), and macular edema. A total of 23 studies with 1749 eyes were included. Twelve different drugs or drug combinations were assessed. The NMA was performed for retinal reattachment, PVR recurrence, and reoperation rate outcomes. Among the pharmacological agents analyzed, adjunctive therapy with 13-cis-retinoic acid (13-cis-RA) demonstrated a statistically significant improvement in retinal reattachment rates (RR=1.36, 95 % CI: 1–1.84) and a reduction in reoperation rates (RR=0.23, 95 % CI: 0.07–0.69) compared to the control group, while none of the other drugs had statistically significant results. Additionally, adjunctive therapy did not yield significant improvements in IOP, ERM, or macular edema, except for a reduction in macular edema associated with dexamethasone in one study. This systematic review and NMA indicate that most pharmacological agents could not significantly improve retinal reattachment, reduce PVR recurrence, or lower reoperation rates following RD surgery. 13-cis-RA was the only drug that showed a significant impact on lowering retinal detachment and reoperation rates. Further high-quality clinical trials are warranted to confirm these findings.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 4","pages":"Pages 633-644"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qi Zhang , Shaopan Wang , Xu Wang , Changsheng Xu , Jiajun Liang , Zuguo Liu
{"title":"Advancing ophthalmology with large language models: Applications, challenges, and future directions","authors":"Qi Zhang , Shaopan Wang , Xu Wang , Changsheng Xu , Jiajun Liang , Zuguo Liu","doi":"10.1016/j.survophthal.2025.02.009","DOIUrl":"10.1016/j.survophthal.2025.02.009","url":null,"abstract":"<div><div>In recent years, with the rapid development of artificial intelligence (AI) technology, large language models (LLMs), as powerful tools, are expected to transform traditional medical practices and improve medical efficiency and quality. In the field of ophthalmology, LLMs not only assist doctors in diagnosing eye diseases, optimizing treatment recommendations, improving medical record-writing efficiency, and providing educational training support, but also offer strong support for ophthalmic researchers in data processing and innovative research. LLMs, however, face numerous challenges in clinical applications, such as knowledge boundaries, AI hallucinations, and data privacy protection. We summarize the progress of LLM applications in the field of ophthalmology and highlight the challenges, providing references for their future use in clinical practice.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 1019-1028"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skenda Jean-Charles , Marissa K. Shoji , Don O. Kikkawa , M. Tariq Bhatti
{"title":"The mirrored arterial dilemma","authors":"Skenda Jean-Charles , Marissa K. Shoji , Don O. Kikkawa , M. Tariq Bhatti","doi":"10.1016/j.survophthal.2025.02.006","DOIUrl":"10.1016/j.survophthal.2025.02.006","url":null,"abstract":"<div><div>An 89-year-old man presented with acute and painless loss of vision in his left eye. He denied constitutional symptoms. Visual acuity was light perception with pallid optic disc edema. Neurological work-up and serological inflammatory markers were normal. Due to the clinical suspicion for giant cell arteritis (GCA), he was started on corticosteroid therapy and bilateral temporal artery biopsies (TABs) were performed. Histopathology of the left temporal artery ipsilateral to the visual loss was negative for arteritis, while the contralateral temporal artery was positive for arteritis. The diagnostic evaluation of GCA and value of unilateral versus bilateral TABs is discussed.</div></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"70 5","pages":"Pages 1029-1033"},"PeriodicalIF":5.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}