Survey of ophthalmology最新文献_第6页

Detection of choroidal vascular features in diabetic patients without clinically visible diabetic retinopathy by optical coherence tomography angiography: A systemic review and meta-analysis. 通过光学相干断层血管造影术检测无临床可见糖尿病视网膜病变的糖尿病患者脉络膜血管特征：系统回顾与荟萃分析。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-28 DOI: 10.1016/j.survophthal.2024.08.007

Qing Zhao, Linxin Wei, Youxin Chen

{"title":"Detection of choroidal vascular features in diabetic patients without clinically visible diabetic retinopathy by optical coherence tomography angiography: A systemic review and meta-analysis.","authors":"Qing Zhao, Linxin Wei, Youxin Chen","doi":"10.1016/j.survophthal.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.007","url":null,"abstract":"<p><p>Researchers have explored choroidal features in the eyes of diabetic patients without clinically visible diabetic retinopathy (DM-NoDR) employing optical coherence tomography angiography (OCTA); however, the results are controversial. We systematically searched PubMed, Embase, and Ovid databases for OCTA studies comparing choroidal parameters between DM-NoDR eyes and healthy controls or non-proliferative diabetic retinopathy (NPDR) eyes. Outcomes included choriocapillaris (CC) perfusion density (PD), flow area (FA), and flow deficits (FD). 36 studies were finally included in the quantitative meta-analysis, involving 1,908 DM-NoDR eyes, 792 NPDR eyes, and 1,391 healthy control eyes. DM-NoDR eyes had significantly lower CC PD in the foveal region (P=0.0005) and superior parafoveal region (P=0.003) than healthy control eyes, but no significant difference was found in other parafoveal subregions (P>0.05). DM-NoDR eyes were also associated with increased CC FD (P<0.00001) and decreased CC FA (P<0.0001) in whole OCTA images with a 3×3 mm<sup>2</sup> field of view (FOV). Compared with all-stage NPDR eyes, DM-NoDR eyes had higher CC PD in the foveal region (P<0.0001), parafoveal region (P<0.00001), and the whole OCTA images with a 6×6 mm<sup>2</sup> FOV (P<0.00001). Early choroidal microvascular changes may precede clinically visible DR and can be detected early using OCTA in DM-NoDR eyes.</p>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of immune modulators in age-related macular degeneration 免疫调节剂在老年性黄斑变性中的作用。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-06 DOI: 10.1016/j.survophthal.2024.07.009

Lukas Schloesser , Sara M. Klose , Matthias M. Mauschitz , Zeinab Abdullah , Robert P. Finger

{"title":"The role of immune modulators in age-related macular degeneration","authors":"Lukas Schloesser , Sara M. Klose , Matthias M. Mauschitz , Zeinab Abdullah , Robert P. Finger","doi":"10.1016/j.survophthal.2024.07.009","DOIUrl":"10.1016/j.survophthal.2024.07.009","url":null,"abstract":"<div><p>We provide an overview of the expanding literature on the role of cytokines and immune mediators in pathophysiology of age-related macular degeneration (AMD). Although many immunological mediators have been linked to AMD pathophysiology, the broader mechanistic picture remains unclear with substantial variations in the levels of evidence supporting these mediators. Therefore, we reviewed the literature considering the varying levels of supporting evidence. A Medical Subject Headings (MeSH) term-based literature research was conducted in September, 2023, consisting of the MeSH terms “cytokine” and “Age-related macular degeneration” connected by the operator “AND”. After screening the publications by title, abstract, and full text, a total of 146 publications were included<strong>.</strong> The proinflammatory cytokines IL-1β (especially in basic research studies), IL-6, IL-8, IL-18, TNF-α, and MCP-1 are the most extensively characterised cytokines/chemokines, highlighting the role of local inflammasome activation and altered macrophage function in the AMD pathophysiology. Among the antiinflammatory mediators IL-4, IL-10, and TGF-β were found to be the most extensively characterised, with IL-4 driving and IL-10 and TGF-β suppressing disease progression. Despite the extensive literature on this topic, a profound understanding of AMD pathophysiology has not yet been achieved. Therefore, further studies are needed to identify potential therapeutic targets, followed by clinical studies</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 851-869"},"PeriodicalIF":5.1,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders. 间充质干细胞在眼表免疫介导疾病中的潜在应用。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-01 DOI: 10.1016/j.survophthal.2024.07.008

Pier Luigi Surico, Vincenzo Barone, Rohan Bir Singh, Marco Coassin, Tomas Blanco, Thomas H Dohlman, Sayan Basu, Sunil K Chauhan, Reza Dana, Antonio Di Zazzo

引用次数: 0

Retinal light damage: From mechanisms to protective strategies 视网膜光损伤：从机制到保护策略

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-23 DOI: 10.1016/j.survophthal.2024.07.004

Zhao Zhang , Xiaoqian Shan , Shujiao Li , Jun Chang , Zhenhua Zhang , Yang Dong , Li Wang , Fengming Liang

{"title":"Retinal light damage: From mechanisms to protective strategies","authors":"Zhao Zhang , Xiaoqian Shan , Shujiao Li , Jun Chang , Zhenhua Zhang , Yang Dong , Li Wang , Fengming Liang","doi":"10.1016/j.survophthal.2024.07.004","DOIUrl":"10.1016/j.survophthal.2024.07.004","url":null,"abstract":"<div><p>Visible light serves as a crucial medium for vision formation.;however, prolonged or excessive exposure to light is recognized as a significant etiological factor contributing to retinal degenerative diseases. The retina, with its unique structure and adaptability, relies on the homeostasis of cellular functions to maintain visual health. Under normal conditions, the retina can mount adaptive responses to various insults, including light-induced damage. Unfortunately, exposure to intense and excessive light triggers a cascade of pathological alterations in retinal photoreceptor cells, pigment epithelial cells, ganglion cells, and glial cells. These alterations encompass disruption of intracellular REDOX and Ca²⁺ homeostasis, pyroptosis, endoplasmic reticulum stress, autophagy, and the release of inflammatory cytokines, culminating in irreversible retinal damage. We first delineate the mechanisms of retinal light damage through 4 main avenues: mitochondria function, endoplasmic reticulum stress, cell autophagy, and inflammation. Subsequently, we discuss protective strategies against retinal light damage, aiming to guide research toward the prevention and treatment of light-induced retinal conditions.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 905-915"},"PeriodicalIF":5.1,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000791/pdfft?md5=97bf5044a6e6e379ae3450a24dbc18f7&pid=1-s2.0-S0039625724000791-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in artificial intelligence for meibomian gland evaluation: A comprehensive review 用于睑板腺评估的人工智能的进步：全面回顾。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-23 DOI: 10.1016/j.survophthal.2024.07.005

Li Li , Kunhong Xiao , Xianwen Shang , Wenyi Hu , Mayinuer Yusufu , Ruiye Chen , Yujie Wang , Jiahao Liu , Taichen Lai , Linling Guo , Jing Zou , Peter van Wijngaarden , Zongyuan Ge , Mingguang He , Zhuoting Zhu

{"title":"Advances in artificial intelligence for meibomian gland evaluation: A comprehensive review","authors":"Li Li , Kunhong Xiao , Xianwen Shang , Wenyi Hu , Mayinuer Yusufu , Ruiye Chen , Yujie Wang , Jiahao Liu , Taichen Lai , Linling Guo , Jing Zou , Peter van Wijngaarden , Zongyuan Ge , Mingguang He , Zhuoting Zhu","doi":"10.1016/j.survophthal.2024.07.005","DOIUrl":"10.1016/j.survophthal.2024.07.005","url":null,"abstract":"<div><p>Meibomian gland dysfunction<span><span><span> (MGD) is increasingly recognized as a critical contributor to evaporative dry eye<span>, significantly impacting visual quality. With a global prevalence estimated at 35.8 %, it presents substantial challenges for clinicians. Conventional manual evaluation techniques for MGD face limitations characterized by inefficiencies, high subjectivity, limited big data processing capabilities, and a dearth of quantitative analytical tools. With rapidly advancing artificial intelligence (AI) techniques revolutionizing </span></span>ophthalmology<span>, studies are now leveraging sophisticated AI methodologies--including computer vision, unsupervised learning, and supervised learning--to facilitate comprehensive analyses of meibomian gland<span> (MG) evaluations. These evaluations employ various techniques, including slit lamp examination, </span></span></span>infrared imaging<span><span>, confocal microscopy, and </span>optical coherence tomography. This paradigm shift promises enhanced accuracy and consistency in disease evaluation and severity classification. While AI has achieved preliminary strides in meibomian gland evaluation, ongoing advancements in system development and clinical validation are imperative. We review the evolution of MG evaluation, juxtapose AI-driven methods with traditional approaches, elucidate the specific roles of diverse AI technologies, and explore their practical applications using various evaluation techniques. Moreover, we delve into critical considerations for the clinical deployment of AI technologies and envisages future prospects, providing novel insights into MG evaluation and fostering technological and clinical progress in this arena.</span></span></p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 945-956"},"PeriodicalIF":5.1,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of inflammation in diabetic macular edema and neovascular age-related macular degeneration 炎症在糖尿病黄斑水肿和新生血管性老年黄斑变性中的作用。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-18 DOI: 10.1016/j.survophthal.2024.07.006

Stela Vujosevic , Marco Lupidi , Simone Donati , Carlo Astarita , Valentina Gallinaro , Elisabetta Pilotto

{"title":"Role of inflammation in diabetic macular edema and neovascular age-related macular degeneration","authors":"Stela Vujosevic , Marco Lupidi , Simone Donati , Carlo Astarita , Valentina Gallinaro , Elisabetta Pilotto","doi":"10.1016/j.survophthal.2024.07.006","DOIUrl":"10.1016/j.survophthal.2024.07.006","url":null,"abstract":"<div><p>Diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD) are multifactorial disorders that affect the macula and cause significant vision loss. Although inflammation and neoangiogenesis are hallmarks of DME and nAMD, respectively, they share some biochemical mediators. While inflammation is a trigger for the processes that lead to the development of DME, in nAMD inflammation seems to be the consequence of retinal pigment epithelium and Bruch membrane alterations. These pathophysiologic differences may be the key issue that justifies the difference in treatment strategies. Vascular endothelial growth factor inhibitors have changed the treatment of both diseases, however, many patients with DME fail to achieve the established therapeutic goals. From a clinical perspective, targeting inflammatory pathways with intravitreal corticosteroids has been proven to be effective in patients with DME. On the contrary, the clinical relevance of addressing inflammation in patients with nAMD has not been proven yet. We explore the role and implication of inflammation in the development of nAMD and DME and its therapeutical relevance.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 870-881"},"PeriodicalIF":5.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000808/pdfft?md5=9b6ab2ef69bb5f351f5973af525a9a9f&pid=1-s2.0-S0039625724000808-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting acute retinal pigment epitheliitis (Krill disease) 重温急性视网膜色素上皮炎（克里尔氏病）

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-16 DOI: 10.1016/j.survophthal.2024.07.003

Yousef A. Fouad , Maria Vittoria Cicinelli , Alessandro Marchese , Giuseppe Casalino , Lee M. Jampol

引用次数: 0

Advances in ophthalmic therapeutic delivery: A comprehensive overview of present and future directions 眼科治疗给药的进展：当前和未来发展方向的全面概述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-08 DOI: 10.1016/j.survophthal.2024.07.002

{"title":"Advances in ophthalmic therapeutic delivery: A comprehensive overview of present and future directions","authors":"","doi":"10.1016/j.survophthal.2024.07.002","DOIUrl":"10.1016/j.survophthal.2024.07.002","url":null,"abstract":"<div><p>Ophthalmic treatment demands precision and consistency in delivering therapeutic agents over extended periods to address many conditions, from common eye disorders to complex diseases. This diversity necessitates a range of delivery strategies, each tailored to specific needs. We delve into various delivery cargos that are pivotal in ophthalmic care. These cargos encompass biodegradable implants that gradually release medication, nonbiodegradable implants for sustained drug delivery, refillable tools allowing flexibility in treatment, hydrogels capable of retaining substances while maintaining ocular comfort, and advanced nanotechnology devices that precisely target eye tissues. Within each cargo category, we explore cutting-edge research-level approaches and FDA-approved methods, providing a thorough overview of the current state of ophthalmic drug delivery. In particular, our focus on nanotechnology reveals the promising potential for gene delivery, cell therapy administration, and the implantation of active devices directly into the retina. These advancements hold the key to more effective, personalized, and minimally- invasive ophthalmic treatments, revolutionizing the field of eye care.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 967-983"},"PeriodicalIF":5.1,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000766/pdfft?md5=ac42eb0a67c5ae84598667460f3c89ba&pid=1-s2.0-S0039625724000766-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of stroke development following retinal vein occlusion: A systematic review and meta-analysis 视网膜静脉闭塞后发生中风的风险：系统回顾和荟萃分析。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-03 DOI: 10.1016/j.survophthal.2024.06.007

{"title":"Risk of stroke development following retinal vein occlusion: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.survophthal.2024.06.007","DOIUrl":"10.1016/j.survophthal.2024.06.007","url":null,"abstract":"<div><p>Retinal vein occlusion (RVO) and cerebrovascular disease share common risk factors and may be independently associated; however, the strength and nature of this association remain unclear. We conducted a systematic review and meta-analysis, informed by studies from PubMed, Scopus, EMBASE, Web of Science, and Google Scholar until January 6, 2024, aimed to clarify this relationship. Eligible studies included cohorts observing stroke incidence in RVO patients for over a year. Pooled effect estimates were calculated using random-effects models, with subgroup analyses evaluating associations between RVO types (central and branch) and stroke subtypes (ischemic and hemorrhagic). Ten cohort studies with a total of 428,650 participants (86,299 RVO patients) were included. Compared to controls, RVO patients exhibited a significantly increased risk of stroke (pooled risk ratio [RR]=1.38, 95 % confidence interval (95 %CI)=1.34–1.41). Subgroup analyses indicated elevated risk for both ischemic (RR=1.37, 95 %CI=1.32–1.42) and hemorrhagic (RR=1.55, 95 %CI=1.08–2.22) strokes in RVO patients. Additionally, both central (RR=1.50, 95 %CI=1.27–1.78) and branch (RR=1.41, 95 %CI=1.32–1.50) RVO were associated with stroke risk. Sensitivity analyses confirmed consistent results across various criteria, and funnel plots indicated no publication bias. RVO significantly increases the risk of both ischemic and hemorrhagic stroke, regardless of RVO type, suggesting a strong independent association between these conditions.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 924-936"},"PeriodicalIF":5.1,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic retinopathy: New concepts of screening, monitoring, and interventions 糖尿病视网膜病变：筛查、监测和干预的新概念。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-07-02 DOI: 10.1016/j.survophthal.2024.07.001

{"title":"Diabetic retinopathy: New concepts of screening, monitoring, and interventions","authors":"","doi":"10.1016/j.survophthal.2024.07.001","DOIUrl":"10.1016/j.survophthal.2024.07.001","url":null,"abstract":"<div><p>The science of diabetes care has progressed to provide a better understanding of the oxidative and inflammatory lesions and pathophysiology of the neurovascular unit within the retina (and brain) that occur early in diabetes, even prediabetes. Screening for retinal structural abnormalities, has traditionally been performed by fundus examination or color fundus photography; however, these imaging techniques detect the disease only when there are sufficient lesions, predominantly hemorrhagic, that are recognized to occur late in the disease process after significant neuronal apoptosis and atrophy, as well as microvascular occlusion with alterations in vision. Thus, interventions have been primarily oriented toward the later-detected stages, and clinical trials, while demonstrating a slowing of the disease progression, demonstrate minimal visual improvement and modest reduction in the continued loss over prolonged periods. Similarly, vision measurement utilizing charts detects only problems of visual function late, as the process begins most often parafoveally with increasing number and progressive expansion, including into the fovea. While visual acuity has long been used to define endpoints of visual function for such trials, current methods reviewed herein are found to be imprecise. We review improved methods of testing visual function and newer imaging techniques with the recommendation that these must be utilized to discover and evaluate the injury earlier in the disease process, even in the prediabetic state. This would allow earlier therapy with ocular as well as systemic pharmacologic treatments that lower the and neuro-inflammatory processes within eye and brain. This also may include newer, micropulsed laser therapy that, if applied during the earlier cascade, should result in improved and often normalized retinal function without the adverse treatment effects of standard photocoagulation therapy.</p></div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 6","pages":"Pages 882-892"},"PeriodicalIF":5.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000778/pdfft?md5=cb71f9cabc3b0405457407b2dc74cfed&pid=1-s2.0-S0039625724000778-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0