Survey of ophthalmology最新文献_第5页

Leveraging neural plasticity for the treatment of amblyopia 利用神经可塑性治疗弱视。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.04.006

{"title":"Leveraging neural plasticity for the treatment of amblyopia","authors":"","doi":"10.1016/j.survophthal.2024.04.006","DOIUrl":"10.1016/j.survophthal.2024.04.006","url":null,"abstract":"<div>Amblyopia is a form of visual cortical impairment that arises from abnormal visual experience early in life. Most often, amblyopia is a unilateral visual impairment that can develop as a result of strabismus, anisometropia, or a combination of these conditions that result in discordant binocular experience. Characterized by reduced visual acuity and impaired binocular function, amblyopia places a substantial burden on the developing child. Although frontline treatment with glasses and patching can improve visual acuity, residual amblyopia remains for most children. Newer binocular-based therapies can elicit rapid recovery of visual acuity and may also improve stereoacuity in some children. Nevertheless, for both treatment modalities full recovery is elusive, recurrence of amblyopia is common, and improvements are negligible when treatment is administered at older ages. Insights derived from animal models about the factors that govern neural plasticity have been leveraged to develop innovative treatments for amblyopia. These novel therapies exhibit efficacy to promote recovery, and some are effective even at ages when conventional treatments fail to yield benefit. Approaches for enhancing visual system plasticity and promoting recovery from amblyopia include altering the balance between excitatory and inhibitory mechanisms, reversing the accumulation of proteins that inhibit plasticity, and harnessing the principles of metaplasticity. Although these therapies have exhibited promising results in animal models, their safety and ability to remediate amblyopia need to be evaluated in humans.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 5","pages":"Pages 818-832"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of MYCN in retinoblastoma: A review of current literature MYCN 在视网膜母细胞瘤中的作用：当前文献综述

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.05.009

{"title":"Role of MYCN in retinoblastoma: A review of current literature","authors":"","doi":"10.1016/j.survophthal.2024.05.009","DOIUrl":"10.1016/j.survophthal.2024.05.009","url":null,"abstract":"<div>Chromosomal abnormalities that involve the MYCN gene are rare; however, it is one of the most commonly mutated genes in retinoblastoma (RB) after the RB1 gene. MYCN is amplified in approximately 1–9 % of all RB tumors. It plays a role in RB oncogenesis via many mechanisms, including synergism with RB1 deletion, positive feedback with MDM2, upregulation of cell cycle regulating genes, upregulation of miRNA, and upregulation of glucose metabolism. MYCN amplifications are not mutually exclusive and can occur even in the presence of RB1 gene mutations. Clinically, RB1+/+MYCNA tumors present as sporadic, unilateral, advanced tumors in very young children and tend to follow an aggressive course. Magnetic resonance imaging features include peripheral tumor location, placoid configuration, retinal folding, tumor-associated hemorrhage, and anterior chamber enhancement. Genetic testing for MYCNA is especially recommended in patients with unilateral RB where genetic blood testing and tumor tissue show a lack of RB1 mutation. MYCN-targeted therapies are evolving and hold promise for the future.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 5","pages":"Pages 697-706"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractive surgical approaches to keratoconus: A systematic review and network meta-analysis 角膜病的屈光手术方法：系统综述和网络荟萃分析。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.04.008

{"title":"Refractive surgical approaches to keratoconus: A systematic review and network meta-analysis","authors":"","doi":"10.1016/j.survophthal.2024.04.008","DOIUrl":"10.1016/j.survophthal.2024.04.008","url":null,"abstract":"<div>Advancements in diagnostic methods and surgical techniques for keratoconus (KC) have increased non-invasive treatment options. Successful surgical planning for KC involves a combination of clinical science, empirical evidence, and surgical expertise. Assessment of disease progression is crucial, and halting the progression should be the focus if it is progressive. While surgeons used to rely on experience alone to decide the surgical method, comparing the network of primary factors, such as visual acuity, across studies can help them choose the most appropriate treatments for each patient and achieve optimal outcomes. Meticulous tabulation methods facilitate interpretation, highlighting the importance of selecting the correct surgical and rehabilitation approach based on each patient's condition and stage of the disease. We detail the outcomes of a comprehensive network meta-analysis comparing the effectiveness of various combined therapeutic refractive treatments for KC at identical stages of the disease, spanning 4 distinct follow-up intervals. Additionally, the comprehensive analysis suggests that for corneas with optimal best corrected visual acuity (BCVA) preoperatively (classified as regular), combining phakic intraocular lenses with intracorneal ring segments (ICRS) and corneal cross-linking (CXL) could offer the best therapeutic approach provided the disease stage does not exceed stage 3. For irregular corneas, although initial follow-ups show a significant difference in BCVA with surface ablation, longer-term follow-ups recommend combining surface ablation with ICRS and CXL, especially at higher stages.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 5","pages":"Pages 779-788"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene and cell therapy for age-related macular degeneration: A review 老年性黄斑变性的基因和细胞疗法：综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.05.002

{"title":"Gene and cell therapy for age-related macular degeneration: A review","authors":"","doi":"10.1016/j.survophthal.2024.05.002","DOIUrl":"10.1016/j.survophthal.2024.05.002","url":null,"abstract":"<div>Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among the elderly in Western communities, with an estimated global prevalence of 10 – 20% in people older than 65 years. AMD leads to central vision loss due to degeneration of the photoreceptors, retinal pigment epithelium and the choriocapillaris. Beckman’s classification for AMD, based upon color fundus photographs, divides the disease into early, intermediate, and late forms. The late, vision-threatening stage includes both neovascular AMD and geographic atrophy. Despite its high prevalence and impact on patients’ quality of life, treatment options for AMD are limited. While neovascular AMD can be medically managed with anti-VEGF intravitreal injections, until very recently there has been no approved treatment options for atrophic AMD; however, in February 2023 the first treatment for geographic atrophy – pegcetacoplan – was approved by the US FDA. We describe the current landscape of potential gene and cell therapeutic strategies for late-stage AMD, with an emphasis on the therapeutic options that might become available in the next few years.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 5","pages":"Pages 665-676"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0039625724000493/pdfft?md5=53d23e4f2049ddd0f29381bb5bf5da28&pid=1-s2.0-S0039625724000493-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of ocular damage in systemic lupus erythematosus and risk factors for hydroxychloroquine-related complications 系统性红斑狼疮眼部损伤的临床特征和羟氯喹相关并发症的风险因素。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-09-01 DOI: 10.1016/j.survophthal.2024.05.006

{"title":"Clinical features of ocular damage in systemic lupus erythematosus and risk factors for hydroxychloroquine-related complications","authors":"","doi":"10.1016/j.survophthal.2024.05.006","DOIUrl":"10.1016/j.survophthal.2024.05.006","url":null,"abstract":"<div>Ocular damage in systemic lupus erythematosus (SLE) may cause insidious visual impairment, but its clinical features and the risk of hydroxychloroquine (HCQ)-related complications are still controversial. We performed a meta-analysis to evaluate ocular damage in SLE, the correlation between eye and systemic involvement, and the ocular side effects of treatment. The database PubMed, Embase, and Ovid were used for literature from reception to July, 2023, and the calculation was carried out with R. About 48,693 patients from 66 studies were included. The results indicated that ocular damage in SLE was insidious, appearing in 28 % of patients with no complaints. The most common symptoms and manifestations were dry eye (30 %) and keratoconjunctivitis sicca (26 %). Retinopathy was detected in 10 % of patients and was related to antiphospholipid antibodies (25 % versus 8 %). The proportion of retinopathy also significantly increased in patients with lupus nephropathy or neuropsychiatric systemic lupus erythematosus (risk ratio of 2.29 and 1.95, respectively). HCQ was used in 82 % of patients, of which 4 % suffered from ocular toxicity. HCQ-related retinopathy was dose-dependent. Dosage below 5 mg/kg/d was relatively effective and safe for long-term use, while routine examination was recommended.</div>","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":"69 5","pages":"Pages 733-742"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of patient-reported outcomes in vitreomacular interface disorders: A systematic literature review. 玻璃体界面紊乱的患者报告结果评估：系统性文献综述。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-31 DOI: 10.1016/j.survophthal.2024.08.004

J E Woudstra-de Jong, J J Busschbach, S S Manning-Charalampidou, J R Vingerling, K Pesudovs

{"title":"Assessment of patient-reported outcomes in vitreomacular interface disorders: A systematic literature review.","authors":"J E Woudstra-de Jong, J J Busschbach, S S Manning-Charalampidou, J R Vingerling, K Pesudovs","doi":"10.1016/j.survophthal.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.004","url":null,"abstract":"Patient-reported outcome measures (PROMs) assess the impact of disease on quality of life from the patient's perspective. Our purpose was to provide an overview of current PROMs used for vitreomacular interface disorders: macular hole, epiretinal membrane, and vitreomacular traction. We review the content coverage of all identified PROMs, assess them against quality-of-life issues as identified from earlier qualitative studies, and assess their psychometric quality (measurement properties). We identified 86 studies that used a PROM and 2 qualitative studies on quality of life of patients with a vitreomacular interface disorder. Current PROMs used in vitreomacular interface disorders have a limited content coverage and unknown psychometric quality. The National Eye Institute Visual Functioning Questionnaire was used most. None of the condition-specific PROMs used patient consultation during content development, and there is only a small overlap between the content of PROMs and quality-of-life issues in qualitative studies. Reporting of psychometric quality was sparse, and mostly limited to concurrent validity and responsiveness. There is a need for properly developed and validated PROMs in vitreomacular interface disorders.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular neovascularization. 黄斑新生血管

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-31 DOI: 10.1016/j.survophthal.2024.08.003

Jay U Sheth, Michael W Stewart, Raja Narayanan, Giridhar Anantharaman, Kiran Chandran, Timothy Y Y Lai, Usha Chakravarthy, Taraprasad Das

{"title":"Macular neovascularization.","authors":"Jay U Sheth, Michael W Stewart, Raja Narayanan, Giridhar Anantharaman, Kiran Chandran, Timothy Y Y Lai, Usha Chakravarthy, Taraprasad Das","doi":"10.1016/j.survophthal.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.003","url":null,"abstract":"Neovascularization of the macula, a common complication of many chorioretinal diseases such as neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, and pathologic myopia results from increased synthesis of vascular endothelial growth factor (VEGF) by the retinal pigment epithelium and/or Müller cells because of localized ischemia and inflammation. The Consensus on Neovascular AMD Nomenclature (CONAN) study group acknowledged that these vessels may originate from either the choriocapillaris or the retinal microvasculature, prompting them to propose the term 'macular neovascularization' (MNV) to include intraretinal, subretinal, and sub-pigment epithelial neovascularization localized to the macula. MNV frequently appears as a grey-green macular lesion with overlying intraretinal thickening and/or subretinal exudation, causing metamorphopsia, reduced central vision, relative central scotoma, decreased reading speed, and problems with color recognition. Multimodal imaging with optical coherence tomography (OCT), OCT angiography, dye-based angiographies, fundus autofluorescence, and multiwavelength photography help establish the diagnosis and aid in selecting an appropriate treatment. The standard of care for MNV is usually intravitreal anti-VEGF injections, though thermal laser photocoagulation, verteporfin photodynamic therapy, and vitreoretinal surgery are occasionally used. This current review discusses the etiology and clinical features of MNV, the role of multimodal imaging in establishing the diagnosis, and the available therapeutic options.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incisional choroidal surgery. 脉络膜切开手术

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-31 DOI: 10.1016/j.survophthal.2024.08.002

Fukutaro Mano, Stephen LoBue, Prashant Tailor, Timothy W Olsen

{"title":"Incisional choroidal surgery.","authors":"Fukutaro Mano, Stephen LoBue, Prashant Tailor, Timothy W Olsen","doi":"10.1016/j.survophthal.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.002","url":null,"abstract":"The choroid is a thin layer of highly vascular uveal tissue enclosed externally by sclera and internally by neurosensory retinal tissue. The choroid is a \"middle layer\" ocular tissue with anatomically challenging surgical access. The primary functional role of the choroid is to provide rapid, oxygenated, and nutrient-rich blood flow to both the highly metabolic retinal pigment epithelium and outer retina (i.e. photoreceptors) while simultaneously removing waste products. Historically, incisional choroidal surgery (ICS) has involved tumor biopsy or excision, removal of choroidal neovascular complex or autologous choroidal translocations; however, ICS also holds unique potential for novel and innovative approaches to address macular pathology. Using large-animal surgical studies, researchers have explored ICS with the objective of finding safer and more effective techniques to reduce surgical risks such as bleeding, tissue contraction, and scar tissue formation. We explore the relevant anatomy and embryology, existing surgical techniques, discuss the implications for retinal drug delivery, define ICS guiding principles, and offer a rationale for implementation of ICS into a vitreoretinal surgical practice. We also identify other future challenges and anticipate future innovations that will advance ICS.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic retinal detachment: A contemporary update. 外伤性视网膜脱离：当代更新。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-31 DOI: 10.1016/j.survophthal.2024.08.008

Khushboo Chauhan, Vivek Pravin Dave, Francesc March de Ribot, Rupesh Agrawal, Ahmed B Sallam, Gitalisa Andayani, Chia-Jen Chang, Chung-Hao Hsiao, Mae-Lynn Catherine Bastion, Lars-Olof Hattenbach, Avinash Pathengay, Rajeev Reddy Pappuru

引用次数: 0

Examining the fabric of the eye: Antoni van Leeuwenhoek, the draper and ocular microscopist. 检查眼睛的结构安东尼-范-列文虎克，衣匠和目镜学家。

IF 5.1 2区医学

Survey of ophthalmology Pub Date : 2024-08-28 DOI: 10.1016/j.survophthal.2024.08.006

Alexander James Cameron Jessup, Minas Theodore Coroneo

{"title":"Examining the fabric of the eye: Antoni van Leeuwenhoek, the draper and ocular microscopist.","authors":"Alexander James Cameron Jessup, Minas Theodore Coroneo","doi":"10.1016/j.survophthal.2024.08.006","DOIUrl":"https://doi.org/10.1016/j.survophthal.2024.08.006","url":null,"abstract":"We review Antoni van Leeuwenhoek's (1632 - 1723) microscopic studies of comparative ocular anatomy in humans, mammals, birds, and fish. His contributions in anatomical microscopy to ocular biology has been overshadowed by his prolific work and first observations of protists and bacteria, spermatozoa, red blood cells, and dental plaque. Leeuwenhoek's Delftian optical and artisanal heritage more than compensated for any lack of formal scientific training and, in keeping with his Royal Society ethos, shone light onto the \"fabric of the eye\" in order to better understand its function, which he had extended with his microscopes. He has provided the earliest known microscopic descriptions of the tear film, eyelids, cornea, aqueous, crystalline lens, vitreous, retina, optic nerve, and photoreceptor--as well as the first descriptions of cataract, vitreous floater,s and corneal pathology. His description of the aquatic mammal Cetacean eye foreshadowed an understanding of the optical complexities of aerial and submarine vision of whales. His observations challenged classical teaching at that time, particularly in relation to the optic nerve.","PeriodicalId":22102,"journal":{"name":"Survey of ophthalmology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0