玻璃体切割术后重硅油(Densiron®)内填塞的临床意义:一项系统综述和荟萃分析。

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Karim Dirani, Chaesik Kim, Jeff Park, Andrew Gregory, Ahsan Mir, Gary Abrams, Brittany Hodges, Vivian Rajeswaren, Zach Saad, Pradeepa Yoganathan
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引用次数: 0

摘要

孔源性视网膜脱离(rrd)合并下视网膜破裂(IRBs)是外科手术的重大挑战,缺乏普遍接受的治疗标准。重质硅油(hso),特别是Densiron®68和Densiron XTRA,由于其比重大于水,可以有效地填塞下视网膜,因此已成为有前途的内膜填塞剂。与早期的HSO配方不同,这些较新的HSO变体显示出较低的眼内炎症率,同时保持良好的解剖结果,即使与同时使用巩膜扣(SB)相比;然而,它们的使用仍然有限,特别是在美国。该系统综述评估了与Densiron 68和Densiron XTRA相关的临床适应症、解剖再附着率和眼内炎症。通过对Ovid MEDLINE、EMBASE和Cochrane CENTRAL的综合检索,确定了616篇文献,其中22篇涉及970只眼睛的研究符合纳入标准。合并分析显示,16.7%的油分散和乳化发生率,13.0%的眼内炎症发生率,7.1%的油迁移到前房。值得注意的是,80.1%的病例在去除内膜填塞后实现了解剖性视网膜再植。这些发现强调了Densiron 68和Densiron XTRA在治疗复杂的原发性和继发性rrd方面的有效性,提供了一种潜在的可行解决方案,比以前的hso并发症发生率更低。它们在实现高解剖再附着率方面取得了成功,这使它们成为推进RRD治疗的有前途的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Implications of heavy silicon oil (Densiron®) endotamponade after pars plana vitrectomy: A systematic review and meta-analysis.

Rhegmatogenous retinal detachments (RRDs) with inferior retinal breaks (IRBs) pose significant surgical challenges, lacking a universally accepted treatment standard. Heavy silicone oils (HSOs), specifically Densiron® 68 and Densiron XTRA, have emerged as promising endotamponade agents because of their specific gravity, which is greater than that of water, allowing effective tamponade in the inferior retina. Unlike earlier HSO formulations, these newer variants show reduced rates of intraocular inflammation while maintaining favorable anatomical outcomes, even when compared with concomitant scleral buckle (SB) use; however, their usage remains limited, particularly in the U.S. This systematic review assessed clinical indications, anatomical reattachment rates, and intraocular inflammation linked to Densiron 68 and Densiron XTRA. A comprehensive search of Ovid MEDLINE, EMBASE, and Cochrane CENTRAL identified 616 references, of which 22 studies involving 970 eyes met the inclusion criteria. Pooled analyses revealed a 16.7% rate of oil dispersion and emulsification, 13.0% incidence of intraocular inflammation, and 7.1% occurrence of oil migration into the anterior chamber. Notably, anatomical retinal reattachment following endotamponade removal was achieved in 80.1% of cases. These findings underscore the efficacy of Densiron 68 and Densiron XTRA in managing complex primary and secondary RRDs, offering a potentially viable solution with lower complication rates than prior HSOs. Their demonstrated success in achieving high anatomical reattachment rates positions them as promising tools in advancing RRD treatment.

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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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