Retinal degenerative diseases: Complement system-microglia crosstalk.

IF 5.9 2区 医学 Q1 OPHTHALMOLOGY
Jia Gao, Wei Wang, Ya Mo
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引用次数: 0

Abstract

Retinal degenerative diseases (RDD) are a group of age-related blinding eye diseases characterized by progressive degeneration and functional impairment of retinal photoreceptors or ganglion cells, for which there are currently no effective treatments. The complement system is an important innate immune system in the human body, activated through 3 pathways (classical pathway, lectin pathway, and alternative pathway) to ultimately form a membrane attack complex that acts on target cells. Microglia are the innate immune cells of the retina, responsible for maintaining retinal homeostasis. Complement system activation and microglial activation have been identified in RDD. Complement activation products C3 and C5 generate anaphylatoxins C3a and C5a, whose receptors C3aR and C5aR1 can activate microglia. Activated microglia can further produce complement C1q to activate the complement system, forming a positive feedback loop that exacerbates retinal damage. In this review, we focus on the crosstalk between the complement system and microglia in age-related macular degeneration, diabetic retinopathy, glaucoma, and pathological myopia-related retinal degeneration, and summarize clinical studies targeting the complement system and microglia for the treatment of RDD.

视网膜退行性疾病:补体系统-小胶质细胞串扰。
视网膜退行性疾病(RDD)是一组以视网膜感光细胞或神经节细胞进行性变性和功能损害为特征的年龄相关性致盲眼病,目前尚无有效的治疗方法。补体系统是人体重要的先天免疫系统,通过经典途径、凝集素途径和替代途径激活,最终形成作用于靶细胞的膜攻击复合物。小胶质细胞是视网膜的先天免疫细胞,负责维持视网膜的内稳态。补体系统激活和小胶质细胞激活在RDD中已被确定。补体激活产物C3和C5生成过敏毒素C3a和C5a,其受体C3aR和C5aR1可激活小胶质细胞。被激活的小胶质细胞可进一步产生补体C1q,激活补体系统,形成正反馈循环,加重视网膜损伤。本文就补体系统与小胶质细胞在老年性黄斑变性、糖尿病视网膜病变、青光眼、病理性近视相关性视网膜变性中的相互作用进行综述,并对针对补体系统与小胶质细胞治疗RDD的临床研究进行综述。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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