视网膜色素上皮衰老的作用和衰老治疗药物在年龄相关性黄斑变性中的潜力。

IF 5.9 2区医学 Q1 OPHTHALMOLOGY

Survey of ophthalmology Pub Date : 2025-03-13 DOI:10.1016/j.survophthal.2025.03.004

Yingying Chen MD, Feipeng Jiang, Yue Zeng MD, Meixia Zhang MD

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引用次数: 0

摘要

年龄相关性黄斑变性（AMD）是老年人视力损害的主要原因。越来越多的证据显示AMD患者视网膜色素上皮（RPE）存在细胞衰老。老年RPE在其发病机制中起关键作用。由于衰老相关的分泌表型的发展，衰老的RPE遭受结构和功能改变以及周围微环境的破坏，这有助于视网膜的代谢功能障碍和炎症反应。衰老治疗药物，包括senolytics， senomorphics等，是针对衰老细胞的新型治疗方法，是治疗AMD的有希望的治疗方法。随着老年治疗靶点的开发，减轻AMD的负担是有希望的。

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The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration

Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aging population. Evidence showing the presence of cellular senescence in retinal pigment epithelium (RPE) of patients with AMD is growing. Senescent RPE play a pivotal role in its pathogenesis. The senescent RPE suffers from structural and functional alterations and disruption of the surrounding microenvironment due to the development of the senescence-associated secretory phenotype, which contributes to metabolic dysfunctions and inflammatory responses in the retina. Senotherapeutics, including senolytics, senomorphics and others, are novel treatments targeting senescent cells and are promising treatments for AMD. As senotherapeutic targets are being developed, it is promising that the burden of AMD could be decreased.

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来源期刊

Survey of ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.00%

发文量

138

审稿时长

14.8 weeks

期刊介绍： Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.