Sultan Qaboos University Medical Journal最新文献_第7页

A Rare Pathology Masquerading as Myocardial Infarction. 一种伪装成心肌梗死的罕见病理学

Sultan Qaboos University Medical Journal Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.081

Madan M Maddali, Avinash Chauhan, Pranav S Kandachar, Mohammed Al-Mukhaini

引用次数: 0

Blalock-Taussig Shunt versus Ductal Stenting as Palliation for Duct-Dependent Pulmonary Circulation. 布洛克-陶西格分流术与导管支架植入术作为导管依赖性肺循环的姑息治疗方法。

Sultan Qaboos University Medical Journal Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.073

Hamood Al Kindi, Hasina Al Harthi, Asim Al Balushi, Ahlam Atiq, Samiuddin Shaikh, Khalid Al Alawi, Abdullah Al-Farqani

{"title":"Blalock-Taussig Shunt versus Ductal Stenting as Palliation for Duct-Dependent Pulmonary Circulation.","authors":"Hamood Al Kindi, Hasina Al Harthi, Asim Al Balushi, Ahlam Atiq, Samiuddin Shaikh, Khalid Al Alawi, Abdullah Al-Farqani","doi":"10.18295/squmj.12.2023.073","DOIUrl":"10.18295/squmj.12.2023.073","url":null,"abstract":"Objectives: There is limited data published from outside North America and Europe comparing the outcomes of a modified Blalock-Taussig shunt (MBTS) and ductal stenting as the first palliative procedure for infants with duct-dependent pulmonary circulation. This study reports the National Heart Center's, in Muscat, Oman, experience in comparing the outcomes of these 2 interventions.Methods: This retrospective study included all infants with duct-dependent pulmonary circulation who received either a MBTS or ductal stenting from 2016-2019. The primary outcomes were death or re-interventions. Secondary outcomes included death, subsequent re-interventions, survival to subsequent surgical intervention, survival to hospital discharge, post-procedural mechanical ventilation and duration of intensive care unit stay.Results: A total of 71 patients were included in the study, 33 (46%) of whom received ductal stenting. The prevalence of the primary outcome (death or re-intervention) in the patent ductus arteriosus (PDA) stent group was 54.5% versus 31.6% in the MBTS group but this was not statistically significant (P = 0.06). There was no difference between the 2 groups in terms of time to next surgical intervention (P = 0.233). The PDA stent group had shorter post-procedural, mechanical ventilation and intensive care unit stay durations (P <0.05). Syndromic patients were at higher risk of mortality compared to non-syndromic patients.Conclusion: MBTS and ductal stenting are both acceptable modalities as a palliative intervention for infants with duct-dependant pulmonary circulation. Syndromic patients are at higher risk of mortality. This can be considered an important factor for patient selection.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Annulus Growth Pattern in Patients with Tetralogy of Fallot Prior to Surgical Repair. 法洛氏四联症患者手术修复前肺动脉环的生长模式

Sultan Qaboos University Medical Journal Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.077

Hamood N Al Kindi, Shamsa Al Kaabi, Hasina Al Harthi, Thuraya Al Harthi, Ahmed Al Habsi, Pranav Kandachar

{"title":"Pulmonary Annulus Growth Pattern in Patients with Tetralogy of Fallot Prior to Surgical Repair.","authors":"Hamood N Al Kindi, Shamsa Al Kaabi, Hasina Al Harthi, Thuraya Al Harthi, Ahmed Al Habsi, Pranav Kandachar","doi":"10.18295/squmj.12.2023.077","DOIUrl":"10.18295/squmj.12.2023.077","url":null,"abstract":"Objectives: The size of the pulmonary valve annulus often determines the feasibility of pulmonary valve preservation at the time of intracardiac repair of Tetralogy of Fallot. Currently, there is limited available data regarding the growth pattern and the determining factors that contribute towards pulmonary valve annulus growth.Methods: This retrospective study included patients who underwent surgical repair of Tetralogy of Fallot with or without prior palliation. These patients had an echocardiogram at the time of initial diagnosis and a second echocardiogram prior to intracardiac repair. The sizes of the pulmonary annulus, the right and left pulmonary arteries with z-scores were recorded. Patients with improvement in the pulmonary annulus z-scores between the 2 echocardiographic examinations were allocated in Group I (n = 46) and Group II (n = 68) were those with no improvement.Results: A total of 114 patients were included in the study. The right and left pulmonary arteries size and z scores improved significantly between the 2 echocardiograms. Although the median size of the pulmonary annulus increased between the 2 echocardiograms (6 and 7.9 mm; P<0.001), there was no significant change in the z-score (-2.2, -2.34; P = 0.185). Multivariate logistic regression analysis showed that gender, blood group, presence of collaterals, and palliation with Blalock-Taussig shunt had no impact on the improvement in pulmonary annulus z-score.Conclusion: In Tetralogy of Fallot, the pulmonary valve annulus z-score may not change significantly prior to the intracardiac repair. Although in certain subgroups there may be an improvement, there was no specific factor that could be identified and had an influence on this improvement.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Infarction Ventricular Septal Defect: A quarter century experience. 心梗后室间隔缺损：四分之一世纪的经验

Sultan Qaboos University Medical Journal Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.076

Ahmed Al-Bulushi, Issa Al Salmi, Ahmed Ramadan Ahmed, Fatma Al Rahbi

{"title":"Post-Infarction Ventricular Septal Defect: A quarter century experience.","authors":"Ahmed Al-Bulushi, Issa Al Salmi, Ahmed Ramadan Ahmed, Fatma Al Rahbi","doi":"10.18295/squmj.12.2023.076","DOIUrl":"10.18295/squmj.12.2023.076","url":null,"abstract":"Objectives: Post-infarction ventricular septal defect (VSD) is one of the known complications after acute myocardial infarction. This study investigated the clinical results after surgical repair of VSD.Methods: This retrospective study included all patients undergoing surgical repair of VSD from 1996 to 2020 in Oman.Results: Out of a total of 75 patients, 62.5% were men, with a mean age of 59 years. The mean follow-up was 17.2 (7.5) years. Of the 75 patients, 34 (45.3%) patients died within 30 days. Total survival was 41.3% at 5 years, while the 10-year survival rate was 33.3%. Outcomes and predictors for 30 days mortality were the number of concomitant coronary involvement and anastomoses performed, residual postoperative shunt and postoperative dialysis.Conclusion: Even with surgical repair, early mortality of post-infarction septal defect is still considerably high. Early repair and the anatomically posterior rupture are predictors of early mortality. In patients surviving the immediate postoperative period, long-term survival is limited by pre-existing coronary artery disease, postoperative renal failure and the presence of a residual postoperative shunt.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct and Moderating Effects of Work Environment and Structural Empowerment on Job Stress and Job Satisfaction Among Nurses in Oman. 工作环境和结构赋权对阿曼苏丹国护士工作压力和工作满意度的直接和适度影响

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.5.2023.031

Raeda AbuAlRub, Sulaiman D Al Sabei, Omar Al-Rawajfah, Leodoro J Labrague, Ikram A Burney

{"title":"Direct and Moderating Effects of Work Environment and Structural Empowerment on Job Stress and Job Satisfaction Among Nurses in Oman.","authors":"Raeda AbuAlRub, Sulaiman D Al Sabei, Omar Al-Rawajfah, Leodoro J Labrague, Ikram A Burney","doi":"10.18295/squmj.5.2023.031","DOIUrl":"10.18295/squmj.5.2023.031","url":null,"abstract":"Objectives: This study aimed to explore the relationships between nurses' work environment, job stress and job satisfaction, along with the moderating effects of work environment and empowerment on the relationship between job stress and job satisfaction.Methods: A descriptive correlational design was utilised for this study. The study encompassed a convenience sample of 1,796 hospital nurses from the 11 governorates in Oman. Moreover, a self-report questionnaire that included a set of instruments was used to collect the data.Results: Nurses who perceived higher levels of job stress reported lower levels of satisfaction and empowerment and perceived their work environment as less favourable and supportive. The findings only confirmed the direct effects of work environment and empowerment on satisfaction, whereas no support was found for indirect or moderating effects. Furthermore, the hierarchical regression model showed that 46.5% of the variation in the level of job satisfaction was explained by the study variables.Conclusion: The results of this study demonstrate the importance of implementing strategies that empower staff, provide a supportive and positive work environment and tackle job stress to enhance levels of job satisfaction.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44898369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and Awareness of Emergency Medical Physicians on the Management of Traumatic Dental Avulsion at Sultan Qaboos University Hospital. 苏丹卡布斯大学医院急诊医生对外伤性牙痛管理的认识和认识

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.5.2023.030

Sara Al Barkhati, Ali Al Mullahi

{"title":"Knowledge and Awareness of Emergency Medical Physicians on the Management of Traumatic Dental Avulsion at Sultan Qaboos University Hospital.","authors":"Sara Al Barkhati, Ali Al Mullahi","doi":"10.18295/squmj.5.2023.030","DOIUrl":"10.18295/squmj.5.2023.030","url":null,"abstract":"Objectives: This study aimed to assess the level of knowledge regarding traumatic dental avulsion management among emergency physicians at Sultan Qaboos University Hospital (SQUH), Muscat, Oman.Methods: This cross-sectional, survey-based observational study was conducted among emergency physicians at SQUH from August 2021 to October 2021. The data were collected through a standardised and validated questionnaire. Fisher's exact test and Mann-Whitney U tests were used to analyse the data.Results: A total of 18 completed questionnaire forms were received (response rate: 72.0%). The data revealed that 66.7% of the participants had prior knowledge of avulsion management, and 50% had received education on dental trauma. However, 83.0% of the participants did not feel comfortable replanting an avulsed tooth themselves. Regarding their knowledge level, 45.0% of the participating physicians demonstrated low knowledge, 22.2% demonstrated moderate knowledge and 33.3% demonstrated high knowledge. Thus, 94.0% of the participants were interested in acquiring information about avulsion management.Conclusion: The level of knowledge was significantly associated with receiving dental education and a higher clinical grade. As a result, it is crucial to include information about avulsion and its management in both medical undergraduate and post-graduate curricula.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45356875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caregiving Preparedness and Caregiver Burden in Omani Family Caregivers for Patients with Acquired Brain Injury. 阿曼获得性脑损伤患者家庭护理人员的护理准备和护理人员负担

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.6.2023.040

Hema Roslin, Joshua K Muliira, Eilean R Lazarus, Devakirubai Jacob, Warda Al-Habsi, Fatma Al-Musallami

{"title":"Caregiving Preparedness and Caregiver Burden in Omani Family Caregivers for Patients with Acquired Brain Injury.","authors":"Hema Roslin, Joshua K Muliira, Eilean R Lazarus, Devakirubai Jacob, Warda Al-Habsi, Fatma Al-Musallami","doi":"10.18295/squmj.6.2023.040","DOIUrl":"10.18295/squmj.6.2023.040","url":null,"abstract":"Objectives: This study aimed to explore the caregiving preparedness and caregiver burden among Omani family caregivers (FCs) of patients with acquired brain injury (ABI).Methods: This prospective observational study was conducted at the neurology clinic at Khoula Hospital, Muscat, Oman, from April 2019 to December 2021. Data were collected from 119 FCs and their patients at the time of discharge from the hospital and 16 weeks post-discharge during follow-up care. The questionnaire comprised the Zarit Burden Index, the Preparedness for Caregiving Scale, the Short-Form-12 Health Survey, and a patient symptom scale.Results: The FCs were predominantly female (53.8%), and the mean age was 38.27 ± 9.11 years. Most patients had moderate to severe ABI (95.8%) due to stroke (56.3%) and trauma (30.3%). The most common patient symptoms were loss of muscle strength, speech problems, mood problems, memory loss, and change in behaviour. Most FCs were found to have low caregiving preparedness (58%) at discharge, and 19.1% were found to have a high level of caregiver burden at 16 weeks post-discharge. The length of time post-injury (P <0.01), symptom severity (P <0.01) and the FCs' physical and mental health status (P <0.01 each) were found to be significant predictors of caregiving preparedness, whereas caregiver preparedness (P <0.01), symptom severity (P <0.01), and caregivers' mental health (P = 0.028) were seen as the predictors of caregiver burden.Conclusion: Omani FCs of patients with ABI tend to commence the caregiver role with inadequate preparation, and shortly after, a significant number suffer high caregiver burden. Interventions focusing on the caregiver's health and training in symptom management may improve the outcomes of FCs and patients.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42732512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Quality of Life Among Omani Family Caregivers of Patients With Traumatic Brain Injury. 阿曼家庭护理人员对创伤性脑损伤患者生活质量的预测因素

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.5.2023.028

Devakirubai Jacob, Joshua K Muliira, Eilean R Lazarus, Hema Roslin

{"title":"Predictors of Quality of Life Among Omani Family Caregivers of Patients With Traumatic Brain Injury.","authors":"Devakirubai Jacob, Joshua K Muliira, Eilean R Lazarus, Hema Roslin","doi":"10.18295/squmj.5.2023.028","DOIUrl":"10.18295/squmj.5.2023.028","url":null,"abstract":"Objectives: This study aimed to explore the quality of life (QoL) of Omani family caregivers (FCs) of patients with traumatic brain injury (TBI). After acute care, the burden of caring for patients with TBI is mainly shouldered by FCs.Methods: This cross-sectional study was conducted at Khoula Hospital, Muscat, Oman. Patient data were collected at the time of discharge and 8 weeks post-discharge between April 2019 and December 2021. The SF-12 General Health Survey and Preparedness for Caregiving scale were used to measure the caregivers' QoL and preparedness, respectively. The Disability Rating and TBI Symptom scales were used to measure the patients' disability and symptoms, respectively.Results: A total of 36 FCs and patients with TBI were recruited. Most caregivers were the parent (41.7%) or child (27.8%) of the patient with TBI. Overall, the caregivers had good physical QoL (PQoL) and mental health QoL (MHQoL) but low caregiving preparedness at the time of discharge. At 8 weeks post-discharge, there were significant improvements in caregiving preparedness (P <0.01) and patient disability (P <0.05) but a depreciation in caregivers' MHQoL (P <0.05), with no change in their PQoL. The caregiver's employment status and the severity of the patient's sleep and mood problems were modifiable predictors of the caregivers' PQoL. Caregiver's preparedness, the patient's inability to live independently, and the severity of the patient's mood and behavioural problems were predictors of caregivers' MHQoL.Conclusion: Caring for patients with TBI negatively impacts the QoL of Omani FCs; this correlates with the physical, emotional, and mental health symptoms of the patient.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46278256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of a Direct Incarcerated Inguinal Hernia Containing an Epiploic Appendage and a Literature Review. 包含外膜阑尾的直接嵌顿腹股沟疝罕见病例及文献综述。

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2022.072

Stella Papamichail, Eleni Karlafti, Petra Malliou, Apostolos Zatagias, Aristeidis Ioannidis, Smaro Netta, Stavros Panidis, Daniel Paramythiotis

{"title":"A Rare Case of a Direct Incarcerated Inguinal Hernia Containing an Epiploic Appendage and a Literature Review.","authors":"Stella Papamichail, Eleni Karlafti, Petra Malliou, Apostolos Zatagias, Aristeidis Ioannidis, Smaro Netta, Stavros Panidis, Daniel Paramythiotis","doi":"10.18295/squmj.12.2022.072","DOIUrl":"https://doi.org/10.18295/squmj.12.2022.072","url":null,"abstract":"Inguinal hernias are a widespread condition, responsible for a large number of acute abdomen cases. Typically, indirect, rather than direct, hernias lead to complications, as a consequence of their narrower hernial defect. We report a 71-year-old male patient with a rather rare incidence of a direct incarcerated hernia who presented with acute pain in the left inguinal area at a university general hospital in Thessaloniki, Greece, in 2017. Upon clinical examination, an irreducible inguinal mass was palpated. Therefore, the existence of a complicated hernia was suspected. The patient underwent an emergency repair, during which it was established that the hernia was direct and incarcerated and that its sac contained an ischaemic epiploic appendage. The hernia was successfully repaired with mesh, the patient recovered uneventfully and was discharged five days later. Despite the rarity of complicated direct inguinal hernias, they should always be included in the differential diagnosis of irreducible groin masses as they can increase severe complications.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression Patterns of ER, PR, HER-2/neu and p53 in Association with Nottingham Tumour Grade in Breast Cancer Patients. ER、PR、Her-2/neu和p53的表达模式与诺丁汉肿瘤分级相关

Sultan Qaboos University Medical Journal Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.7.2023.044

Kamoru A Adedokun, Waheed A Oluogun, Musiliu A Oyenike, Sikiru O Imodoye, Lukman A Yunus, Smaila A Lasisi, Ibrahim O Bello, Ramat T Kamorudeen, Saheed A Adekola

{"title":"Expression Patterns of ER, PR, HER-2/neu and p53 in Association with Nottingham Tumour Grade in Breast Cancer Patients.","authors":"Kamoru A Adedokun, Waheed A Oluogun, Musiliu A Oyenike, Sikiru O Imodoye, Lukman A Yunus, Smaila A Lasisi, Ibrahim O Bello, Ramat T Kamorudeen, Saheed A Adekola","doi":"10.18295/squmj.7.2023.044","DOIUrl":"10.18295/squmj.7.2023.044","url":null,"abstract":"Objectives: Recent molecular studies show that breast cancer (BC) is a heterogeneous disease, and several molecular changes may accumulate over time to influence treatment response. As a result, employing reliable molecular biomarkers to monitor these modifications may help deliver personalised treatment. However, this may be unrealistic in the resource-limited parts of the world. Thus, this study aimed to investigate the expression pattern of hormone receptors and p53 tumour suppressor using immunohistochemistry (IHC) in BC compared to the traditional tumour grade.Methods: In total, 205 cases were investigated, and the Modified Bloom-Richardson score system was adopted in grading the tumours. The tissue sections of the cases were stained with specific primary antibodies at dilutions of 1:60 for oestrogen receptors (ER) and progesterone receptors (PR), 1:350 for the human epidermal growth factor (HER-2/neu) and 1:50 for p53.Results: Invasive ductal carcinoma of no-specific type (n = 190, 92.7%) was predominant and grade II tumour (n = 146, 71.2%) was the most frequent. Hormone receptors ER (n = 127) and PR (n = 145) had 62.0% and 70.7% positive cases, respectively; 34.1% (n = 70) were positive for HER-2/neu, while 76.1% (n = 156) were positive for p53. Significant associations between Nottingham grade and expression patterns of ER (P <0.01), PR (P <0.001), HER-2/neu (P <0.001) and p53 (P = 0.001) were observed.Conclusion: Nottingham grade had a high degree of concordance with the patterns of expression of hormone receptors, HER-2/neu and p53, suggesting that it may play an important role in connection with the predictive and prognostic biomarkers for BC.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10712386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42824035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0