Skin Appendage Disorders最新文献_第6页

With or without Silicones? A Comprehensive Review of Their Role in Hair Care. 有没有有机硅？它们在头发护理中的作用的综合综述。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-30 DOI: 10.1159/000546651

Raquel de Melo Carvalho, Daniel Fernandes Melo, Awatef Kelati, Antonella Tosti

{"title":"With or without Silicones? A Comprehensive Review of Their Role in Hair Care.","authors":"Raquel de Melo Carvalho, Daniel Fernandes Melo, Awatef Kelati, Antonella Tosti","doi":"10.1159/000546651","DOIUrl":"10.1159/000546651","url":null,"abstract":"Background: Silicones are unique polymers characterized by their repeating siloxane bonds, which have become essential in the hair care industry due to their protective and conditioning properties. Widely incorporated into various hair products, silicones form a film over the hair shaft, reducing friction, preventing moisture loss, and enhancing shine. However, concerns regarding product buildup from water-insoluble silicones and the environmental implications of certain cyclic silicones have emerged. Recent advancements in silicone technology, including water-dispersible and nano-encapsulated systems, aim to mitigate these issues while preserving the benefits of enhanced hair texture and protection against thermal and chemical damage.Summary: This article provides a comprehensive review of the classification, advantages, and controversies surrounding silicones in hair care. It emphasizes practical guidance for selecting appropriate products tailored to individual hair types and the importance of preventing excessive buildup. The discussion highlights the need for education on the benefits and proper use of silicones, addressing common misconceptions. Ultimately, while silicones offer significant advantages in hair care, a balanced approach combining efficacy with environmental responsibility is essential for their continued use as a viable solution in the industry.Key messages: Silicones provide numerous advantages, including enhanced hair texture, improved appearance, and increased moisture retention in hair care formulations. Water-insoluble silicones can accumulate on the hair, requiring the use of stronger surfactants for removal, which may lead to dryness associated with the excessive application of clarifying products. Fourth-generation silicones and innovative surfactant systems are designed to minimize environmental impact while optimizing the targeted delivery of active ingredients.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psoriatic Alopecia: Clinical Features, Pathogenesis, and Emerging Treatment Strategies. 银屑病性脱发：临床特征、发病机制和新兴治疗策略。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-28 DOI: 10.1159/000545835

Eitan Pirov, Yuval Ramot

{"title":"Psoriatic Alopecia: Clinical Features, Pathogenesis, and Emerging Treatment Strategies.","authors":"Eitan Pirov, Yuval Ramot","doi":"10.1159/000545835","DOIUrl":"10.1159/000545835","url":null,"abstract":"Background: Psoriatic alopecia is a distinct but underrecognized manifestation of psoriasis, leading to both non-scarring and scarring hair loss. While scalp involvement is common in psoriasis, the mechanisms underlying follicular damage and hair loss remain poorly understood. Diagnosis is challenging due to clinical and histopathological overlap with other alopecias, and treatment responses are often variable.Summary: This review examines the clinical presentation, pathogenesis, and management of psoriatic alopecia. The inflammatory process, primarily driven by the Th17/IL-23 axis, contributes to hair follicle disruption, sebaceous gland atrophy, and in severe cases, permanent alopecia. Trichoscopy and histopathology aid in diagnosis, but standardized criteria are lacking. Treatment strategies include topical corticosteroids, vitamin D analogs, and systemic biologics, but some patients remain refractory to conventional therapies. Paradoxical psoriatic alopecia induced by TNF inhibitors further complicates management, necessitating individualized treatment approaches.Key messages: Psoriatic alopecia requires greater clinical recognition and research to improve diagnosis and treatment. A deeper understanding of its pathogenesis, particularly immune-mediated follicular damage, could lead to more effective therapies. Personalized treatment approaches, including novel biologics, hold promise for improving patient outcomes, but further studies are needed to optimize long-term management strategies.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hair Transplant in Patchy Scarring Alopecia of the Fronto-Temporal Area. 植发治疗额颞区斑状瘢痕性脱发。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-28 DOI: 10.1159/000546631

Leticia Arsie Contin, Gustavo Batista de Almeida Faro, Leopoldo Duailibe Nogueira Santos, Vanessa Barreto Rocha

{"title":"Hair Transplant in Patchy Scarring Alopecia of the Fronto-Temporal Area.","authors":"Leticia Arsie Contin, Gustavo Batista de Almeida Faro, Leopoldo Duailibe Nogueira Santos, Vanessa Barreto Rocha","doi":"10.1159/000546631","DOIUrl":"10.1159/000546631","url":null,"abstract":"Introduction: Patchy scarring alopecia in the fronto-temporal areas presents a diagnostic challenge, requiring accurate recognition for proper management. Cicatricial marginal alopecia (CMA) and frontal fibrosing alopecia (FFA) are key differential diagnoses, distinguishable through histopathology. FFA has variable prognosis, depending on typical or atypical patterns. Literature on hair transplantation (HT) in CMA and FFA is limited, with inconsistent outcomes and little data on FFA subtypes. This study aimed to describe HT outcomes in patients with atypical FFA patterns.Case presentation: Patients were followed at the Municipal Public Servant Hospital of São Paulo, Brazil, from 2016 to 2023. Three postmenopausal women with patchy FFA confirmed by clinical and histological criteria underwent HT using the follicular unit transplantation technique. Over 5 to 6 years of follow-up, two patients had mild graft loss, and one experienced more significant loss. No clinical signs of disease reactivation were observed.Conclusion: Despite the small sample size and retrospective design, this study offers valuable insight into long-term graft survival in atypical FFA. Mild hair density reduction occurred after more than 5 years, with all patients reporting high satisfaction with aesthetic results. Larger prospective studies are needed to confirm long-term HT efficacy in this population.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12201952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Minoxidil Use in Yellow Nail Syndrome: Report of 2 Cases. 口服米诺地尔治疗黄指甲综合征2例报告。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-05-28 DOI: 10.1159/000546583

Karishma Desai, Hadar Lev-Tov, Brian W Morrison

引用次数: 0

Epidemiological, Clinical, and Therapeutic Insights into Folliculitis Decalvans in Skin of Color: A Retrospective Descriptive Study of 17 Cases. 有色皮肤Decalvans毛囊炎的流行病学、临床和治疗见解：17例回顾性描述性研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-28 DOI: 10.1159/000546565

Zineb Loubaris, Hajar Elhassani Taib, Laila Benzekri, Mariame Meziane

{"title":"Epidemiological, Clinical, and Therapeutic Insights into Folliculitis Decalvans in Skin of Color: A Retrospective Descriptive Study of 17 Cases.","authors":"Zineb Loubaris, Hajar Elhassani Taib, Laila Benzekri, Mariame Meziane","doi":"10.1159/000546565","DOIUrl":"10.1159/000546565","url":null,"abstract":"Introduction: Folliculitis decalvans (FD) is a neutrophilic scarring alopecia characterized by follicular pustules, crusts, and tufted hair. Its etiology remains unclear, though Staphylococcus aureus infection and immune dysfunction are implicated. This study investigates the clinical, dermoscopic, and therapeutic aspects of FD in a skin of color population. The objective of our study was to analyze the epidemiological profile, clinical diversity, diagnostic features, and treatment strategies for FD patients.Methods: A retrospective, descriptive study of 17 FD patients was conducted at Ibn Sina University Hospital, Rabat, over 4 years. Diagnosis was based on clinical, dermoscopic, and histological findings. Data collected included demographics, disease onset, comorbidities, symptoms, severity grading, and therapeutic responses.Results: The cohort comprised 17 patients (8 men, 9 women) with a median age of 37.2 years. Phototype IV was predominant (47.1%). The vertex was the most affected site (82.4%). Scarring alopecia was present in all cases, with perifollicular erythema (100%) and tufted hair (88.2%) being the most common dermoscopic findings. Grade 3 severity was observed in 55.5% of female patients. Topical and oral antibiotics, including doxycycline, were the most prescribed treatments. Resistance to treatment was more common in women.Conclusions: FD in skin of color patients exhibits clinical, dermoscopic, and therapeutic patterns comparable to global data, though higher severity and pustule prevalence were noted. Doxycycline and topical agents remain key therapeutic options. Larger studies are needed to elucidate pathogenesis and optimize management strategies.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12201950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series of a Previously Undescribed Ulcerative Variant of Hidradenitis Suppurativa. 先前未描述的化脓性汗腺炎溃疡性变异的病例系列。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-05-22 DOI: 10.1159/000546319

Fiona Gruzmark, Sydney R Resnik, Raji R Nagalla, Barry Resnik, Paul Hazen, Hadar Lev-Tov

引用次数: 0

Trichoscopy of Terra Firma-Forme Dermatosis of the Scalp: A Case Report. 头皮实形性皮肤病的毛发镜检查1例。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-22 DOI: 10.1159/000546084

Gianluca Tavoletti, Laura Bernal Masferrer, Mauro Barbareschi, Angelo Valerio Marzano, Andrea Sechi

引用次数: 0

Hyperhidrosis Clinical Trial Disparities: Enrollment and Reporting Trends. 多汗症临床试验差异：入组和报告趋势。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-14 DOI: 10.1159/000546318

Lauren Gawey, Aditya Joshi, Caitlyn B Dagenet, Kyla N Price, Khiem A Tran, Jennifer L Hsiao, Vivian Y Shi

{"title":"Hyperhidrosis Clinical Trial Disparities: Enrollment and Reporting Trends.","authors":"Lauren Gawey, Aditya Joshi, Caitlyn B Dagenet, Kyla N Price, Khiem A Tran, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1159/000546318","DOIUrl":"10.1159/000546318","url":null,"abstract":"Introduction: Hyperhidrosis is a chronic condition of excessive sweating with a significant impact on quality of life. Although recent therapeutic advances have expanded treatment options, clinical trial data may lack generalizability due to underrepresentation of diverse populations. This study examined geographic distribution, racial/ethnic representation, and demographic reporting trends in randomized controlled trials (RCTs) for hyperhidrosis.Methods: A search of ClinicalTrials.gov in November 2024 identified completed phase 2 and 3 interventional RCTs for hyperhidrosis from 2005 to 2024. Demographics were extracted from trial registries and associated PubMed publications. Race and ethnicity were categorized per US Census definitions, and geographic representation was analyzed by continent.Results: Thirty-two RCTs with 4,904 participants were included. Most were US-based (62.5%) and only 53.1% reported race/ethnicity. Among reported participants, 55.1% were White, 10.3% Black, 4.1% Asian, and 13% Hispanic/Latino. Race/ethnicity was unknown or unreported for 28.5% of participants. Reporting improved over time (race: 30-63.6%; ethnicity: 20-50%), while geographic diversity declined.Conclusion: Nearly half of hyperhidrosis RCTs failed to report race/ethnicity, and participant diversity remains limited despite improvements. Limited racial/ethnic and geographic diversity undermines the generalizability of trial findings and highlights the need for more inclusive study designs.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric Analysis in Hyperhidrosis: Recent Publication Trends from 2015 to 2025. 多汗症的文献计量分析：2015年至2025年的最新出版趋势。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-08 DOI: 10.1159/000545767

Aditya Joshi, David J Griego, Lauren Gawey, Raveena Ghanshani, Khiem A Tran, Jennifer L Hsiao, Vivian Y Shi

{"title":"Bibliometric Analysis in Hyperhidrosis: Recent Publication Trends from 2015 to 2025.","authors":"Aditya Joshi, David J Griego, Lauren Gawey, Raveena Ghanshani, Khiem A Tran, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1159/000545767","DOIUrl":"10.1159/000545767","url":null,"abstract":"Introduction: Hyperhidrosis is a chronic dermatologic condition that significantly impacts quality of life. While research has expanded in recent years, bibliometric analyses exploring publication trends remain limited. This study examined the 100 most-cited articles from 2015 to 2025 to assess research priorities.Methods: A Scopus search was conducted on January 2, 2025, using the terms \"hyperhidrosis\", \"primary hyperhidrosis\", \"secondary hyperhidrosis\", and \"excessive sweating\". Non-English, abstract-only, and non-hyperhidrosis focused articles were excluded. Two reviewers screened and identified the 100 most-cited publications. Data were analyzed for publication year, authorship, country, study design, journal, and topic focus. The Oxford Centre for Evidence-Based Medicine Level of Evidence (LoE) framework was used to assess study quality.Results: The majority (76%) of highly cited articles were published between 2015 and 2019. Randomized controlled trials (20%), cohort studies (18%), and case-control studies (16%) were the most common study types. Using LoE assessment, 33% of studies were level 1 (high-quality evidence). Research on treatments (55%) dominated, followed by quality of life (12%) and outcome measures (11%). The USA led in publication output.Conclusion: This bibliometric analysis identifies evolving research priorities toward minimally invasive treatments and patient-centered outcomes, providing direction for future research and improvements in clinical practice.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-16"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship between Stigma and Healthcare Interaction in Alopecia Areata. 斑秃病耻感与保健相互作用的关系。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-05-08 DOI: 10.1159/000546216

Ursula Biba, Samantha Gregoire, Katherine Sanchez, Natasha Atanaskova Mesinkovska, Monique Margaret Waldman, Lisa Anderson, Arash Mostaghimi

{"title":"The Relationship between Stigma and Healthcare Interaction in Alopecia Areata.","authors":"Ursula Biba, Samantha Gregoire, Katherine Sanchez, Natasha Atanaskova Mesinkovska, Monique Margaret Waldman, Lisa Anderson, Arash Mostaghimi","doi":"10.1159/000546216","DOIUrl":"10.1159/000546216","url":null,"abstract":"Introduction: People with alopecia areata (AA) experience stigma, but little is known about how this affects healthcare interaction (HCI). We aim to explore the relationship between stigma and HCI in AA.Methods: A cross-sectional survey of 500 members of the National Alopecia Areata Foundation was performed. Survey items related to stigma and HCI were summed and sorted into low, medium, and high tertiles. Multinomial logistic regressions were performed to control for demographic and clinical factors.Results: Respondents (n = 500) were white (80.0%), female (86.2%), and insured (96.0%), with a plurality earning over USD 100,000 annually (34.2%). Participants in the high-stigma subgroup were more likely to be in the low-HCI subgroup (relative risk ratio [RRR]: 2.22; 95% CI: 1.31-3.76; p = 0.003), in comparison to participants in the low- or moderate-stigma subgroups (RRR for both: 0.45; p < 0.05). This relationship was independent of demographics and clinical characteristics. However, data are from a population with limited socioeconomic diversity and high baseline healthcare engagement.Conclusion: People with AA who experience high stigma are less likely to interact with the healthcare system, which cannot be explained by demographics or clinical factors. Stigma and HCI may be related in a dose-dependent manner, and future investigation is needed to support access to care.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0