Skin Appendage Disorders最新文献

{"title":"Kaposi Sarcoma of the Nail Unit: A Case Report and Review of the Literature","authors":"Jonathan Krygier, Ursula Sass, Isabelle Meiers, Alice Marneffe, Marine de Vicq de Cumptich, Bertrand Richert","doi":"10.1159/000532114","DOIUrl":"https://doi.org/10.1159/000532114","url":null,"abstract":"<b><i>Introduction:</i></b> Kaposi sarcoma is an angioproliferative neoplasm. Its manifestations are well known but nail involvement seems extremely underreported. <b><i>Case Presentation:</i></b> A 55-year-old man presented with a 6-month history of a growing subungual tumor affecting the third right toe. After surgical excision, histological examination revealed a Kaposi sarcoma. <b><i>Discussion:</i></b> We report a case of Kaposi sarcoma with nail involvement of only one toe as the first and unique manifestation, which is exceptional.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135620690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dasatinib-Induced Transverse Melanonychia","authors":"Mehul Tyagi, Vishal Gaurav, Japnoor Kaur","doi":"10.1159/000531928","DOIUrl":"https://doi.org/10.1159/000531928","url":null,"abstract":"<b><i>Introduction:</i></b> Transverse melanonychia, characterized by grey to black pigmented bands traversing the nail plate, can occur as a side-effect of certain medications. While no documented reports specifically associate dasatinib, a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia, with nail changes, we present a case of transverse melanonychia possibly related to dasatinib therapy. <b><i>Case Report:</i></b> A 54-year-old male with CML, receiving dasatinib for 1.5 years, presented with transverse pigmented lines involving all fingernails and toenails. Clinical examination revealed discrete bands of transverse melanonychia in the nails. Onychoscopy of all finger- and toenails revealed multiple longitudinal grey lines within transverse grey bands of homogeneous chromonychia. Based on clinical presentation, onychoscopic features, and temporal association with dasatinib therapy, a provisional diagnosis of dasatinib-induced transverse melanonychia was made. <b><i>Discussion:</i></b> The exact mechanisms underlying melanonychia are not fully understood but may involve nail matrix or toxicity, stimulation of nail-matrix melanocytes, or drug deposition within the nail plate. This case highlights the possibility of dasatinib-induced transverse melanonychia and underscores the importance of monitoring and evaluating nail changes in patients undergoing dasatinib treatment.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135876585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Fluconazole-Induced Fixed Drug Eruption of the Digit with Nail Matrix Involvement: A Case Report and Review of the Literature","authors":"Loren E. Hernandez, Arvin Jadoo, Brian Morrison","doi":"10.1159/000532112","DOIUrl":"https://doi.org/10.1159/000532112","url":null,"abstract":"<b><i>Introduction:</i></b> Fixed drug eruptions (FDEs) are cutaneous hypersensitivity reactions due to an offending drug and are rarely associated with nail involvement. Moreover, FDEs associated with fluconazole use are sparsely reported in literature. <b><i>Case Presentation:</i></b> We report a case of a recurrent FDE with involvement of one finger and corresponding Beau’s lines due to fluconazole use. The diagnosis of FDE secondary to fluconazole use was confirmed histopathologically, with improvement after the application of twice daily 0.05% clobetasol propionate ointment. <b><i>Conclusion:</i></b> FDEs are hypersensitivity reactions that occur after exposure to an offending drug. FDEs uncommonly affect the nail matrix and are often not caused by fluconazole. It is important for dermatologists to assess for changes in the nail plate when evaluating a patient with FDE and evaluate all medications a patient is taking.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"441 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136214847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibro-Osseus Pseudotumor of the Digit: A Case Report and Review of Literature","authors":"Chander Grover, Pratibha Gupta, Chhavi Gupta, Kaniyappan Nambiyar, Shitij Goel","doi":"10.1159/000532113","DOIUrl":"https://doi.org/10.1159/000532113","url":null,"abstract":"<b><i>Introduction:</i></b> Bony subungual growths arising on the digital tip are uncommon. Among these, subungual exostosis is a common cause. <b><i>Case Presentation:</i></b> We describe a 35-year-old-male patient with a rare occurrence of a fibro-osseus pseudotumor of the digit. It presents with reactive intramembranous ossification, with no continuity with the distal phalanx, helping differentiate it from a subungual exostosis. The patient presented with an asymptomatic subungual growth, lifting up the nail plate distally causing onycholysis. The characteristic clinical, radiological, and histopathological features of the case are described, which helped confirm the diagnosis. <b><i>Conclusion:</i></b> Cases with fibro-osseus pseudotumor of the digit reported in literature are reviewed comprehensively. The factors helping differentiate this from the other bony tumors affecting the distal phalanx, including subungual exostosis, myositis ossificans, and osteosarcoma are also highlighted.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136214848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study","authors":"Alexandros Katoulis, Ourania Efthymiou, Aikaterini Liakou, Georgia Pappa, Antonios Kanelleas, Dimitra Koumaki, Evangelia Bozi, Dimitrios Sgouros","doi":"10.1159/000531926","DOIUrl":"https://doi.org/10.1159/000531926","url":null,"abstract":"<b><i>Introduction:</i></b> Treatment of hidradenitis suppurativa (HS) is challenging, and in Hurley stage I, it is based on topical measures. Our aim was to compare the efficacy and safety of topical resorcinol 10% with topical clindamycin 1% and no therapy, in Hurley stage I HS. <b><i>Methods:</i></b> In this open, prospective, randomized trial, we studied 60 Hurley stage I patients with IHS4 ≤10. Group A was treated with topical resorcinol 10%; group B with clindamycin lotion 1%; and group C received no treatment. Patients were evaluated by total lesion count, the International Hidradenitis Suppurativa Severity Score System (IHS4) and the Dermatology Life Quality Index (DLQI) at baseline, 12 and 24 weeks. Self-reported number of flares and adverse events (AEs) were recorded. <b><i>Results:</i></b> A significant reduction in the mean total lesion count and DLQI scores were observed in group A, compared to group B at week 12 (<i>p</i> = 0.036, <i>p</i> &amp;lt; 0.001, respectively), and in the mean total lesion count, IHS4, and DLQI scores at week 24 (<i>p</i> = 0.034, <i>p</i> = 0.017, <i>p</i> &amp;lt; 0.001, respectively). Resorcinol 10% was well-tolerated with only mild AEs. <b><i>Conclusion:</i></b> Resorcinol 10% may represent a useful alternative for the long-term treatment of mild HS, which is superior to topical clindamycin and has a favorable safety profile.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135021897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail Unit Arteriovenous Hemangioma Presenting as Longitudinal Erythronychia.","authors":"Jonathan K Hwang, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000530739","DOIUrl":"10.1159/000530739","url":null,"abstract":"<p><strong>Introduction: </strong>Localized longitudinal erythronychia is defined as a single nail with a longitudinal red band extending the length of a nail plate. It has a broad differential of benign and malignant etiologies, and is rarely due to benign vascular proliferations.</p><p><strong>Case presentation: </strong>We present a unique case of nail unit arteriovenous hemangioma presenting as longitudinal erythronychia of the left thumbnail in a 76-year-old male. The band was 6 mm and encompassed over 40% of the surface area of the nail plate. Dermoscopy showed red bands that were regular in terms of color, but not thickness or spacing. Due to concern for an amelanotic melanoma, a longitudinal excision was performed. Histopathology was consistent with a diagnosis of nail unit arteriovenous hemangioma.</p><p><strong>Conclusion: </strong>Arteriovenous hemangiomas were rarely present in the nail unit. They can be present as a blue or red nodule/macule, or as longitudinal erythronychia. Diagnosis often requires an excisional biopsy, with histopathology notable for a proliferation of multiple thick- and thin-walled vascular structures lined by a flattened endothelium. Our case emphasizes the need to consider vascular proliferations, such as arteriovenous hemangioma, in the differential diagnosis of longitudinal erythronychia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"300-305"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subungual Keratoacanthoma: Typical and Atypical Presentations of an Uncommon Nail Tumor.","authors":"Grecia Figueroa-Ramos, Michelle Gatica-Torres, Karla López-López, Judith Domínguez-Cherit","doi":"10.1159/000529724","DOIUrl":"10.1159/000529724","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoacanthoma (KA) is a group of tumors of epidermal origin with controversial nature. Subungual keratoacanthoma (SUKA) is a rare and destructive variant with more aggressive behavior. SUKA appears as a rapidly growing, painful tumor beneath the nail plate that rapidly progresses to a mass that can measure up to 2 cm. The toe location is unusual. The diagnosis must be made based on the correlation of clinical, radiological, and histopathological findings.</p><p><strong>Case presentation: </strong>We present two cases of patients diagnosed with SUKAs with different clinical presentations which ranged from very typical to uncommon one. Both cases were treated with simple excision without recurrences.</p><p><strong>Conclusion: </strong>SUKA is a rare subungual tumor. Nail bed location represents a more difficult diagnostic challenge. SUKA should be suspected in the context of persistent and progressive pain on a finger or toe, once more frequent painful tumors have been ruled out.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"291-295"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Session Fractional CO₂ Laser following Urea Occlusion in Management of Onychomycosis: A Pilot Study.","authors":"Eeshaan Ranjan, Sandeep Arora, Ajay Shanker Sharma, Neha Sharma, Rajeshwari Dabas","doi":"10.1159/000527252","DOIUrl":"10.1159/000527252","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is a common nail disorders. Antifungal resistance, interactions, and side effects limit treatment options. Fractional CO₂ (FCO₂) laser along with topical antifungal is effective in multiple monthly sessions. A modification reducing repeated visits and hence better compliance is preferable. Single-session FCO₂ laser following urea occlusion is reported to be effective. Thus, we conducted a study to determine the efficacy of single-session FCO₂ laser with 1% terbinafine cream with and without \"urea cream occlusion\" in managing onychomycosis.</p><p><strong>Methods: </strong>A prospective, randomized, parallel-group study was conducted at a tertiary centre. Onychomycosis was confirmed by positive fungal mount and culture. Patients were randomized into 2 groups and administered single-session FCO₂ laser. Group A was treated after overnight urea cream occlusion and group B without occlusion. Both groups applied 1% terbinafine cream twice daily for 3 months. Response was assessed by improvement in Onychomycosis Severity Index (OSI) at 6 months.</p><p><strong>Results: </strong>Group A had 10 patients, 14 nails. Clinical improvement was seen in 12/14 (85.7%) nails. Average reduction in OSI was 10.78. Group B had 10 patients, 11 nails. Clinical improvement was seen in 5/11 (45.5%) nails. Average reduction in OSI was 1.73. \"Reduction in OSI\" was statistically significant (<i>p</i> < 0.05) only in group A.</p><p><strong>Conclusion: </strong>Single-session FCO₂ laser following overnight urea cream occlusion, followed by 1% terbinafine cream, is effective for management of onychomycosis.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"268-274"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopic Findings Post Hair Restoration Surgery.","authors":"Leila David Bloch, Helena Rocchetto","doi":"10.1159/000530856","DOIUrl":"10.1159/000530856","url":null,"abstract":"<p><strong>Introduction: </strong>Trichoscopy is a noninvasive diagnostic method for hair and scalp diseases. Data on trichoscopy post hair restoration surgery are limited, and some authors show no relevant changes.</p><p><strong>Case presentation: </strong>Trichoscopic findings in 45 patients are described, after being followed for 12 months after hair restoration surgery. They evolved without any hair disease.</p><p><strong>Conclusion: </strong>Trichoscopy showed some hair shaft abnormalities previously described in alopecia areata and chemotherapy-induced alopecia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"306-308"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy as a Tool to Evaluate Early Dissecting Cellulitis in Patients Affected by Hidradenitis Suppurativa: A Prospective Monocentric Observational Study.","authors":"Marco May Lee, Luigi Naldi, Bianca Maria Piraccini, Michela Starace, Aurora Alessandrini, Andrea Sechi","doi":"10.1159/000530630","DOIUrl":"10.1159/000530630","url":null,"abstract":"<p><strong>Background: </strong>Dissecting cellulitis (DC) is a rare neutrophilic dermatosis that leads to cicatricial alopecia. Although DC and Hidradenitis suppurativa (HS) have similar characteristics, their association remains poorly understood.</p><p><strong>Objectives: </strong>In this prospective observational study, we used trichoscopy to identify subclinical signs of DC in male patients aged 18 years or older, presenting with HS. The objective of this study was to use trichoscopy to identify subclinical signs of DC in patients with confirmed diagnosis of HS.</p><p><strong>Method: </strong>In this prospective, monocentric, observational study, we used trichoscopy to identify subclinical signs of DC in male patients aged 18 years or older, presenting with HS for their initial visit at our HS outpatient clinic from February 1, 2022, to January 31, 2023.</p><p><strong>Results: </strong>Of the 23 male patients with HS, 8 (35%) had subclinical trichoscopy findings consistent with DC. The most frequent location was the vertex (6/8), and the majority of patients had early/inflammatory trichoscopic signs of DC (5/8). Additionally, patients with trichoscopic findings consistent with DC had a higher Hurley stage and the International Hidradenitis Suppurativa Severity Score System (IHS4). Among the cases with trichoscopic findings compatible with DC, the majority (6/8) were classified as having a \"follicular\" HS according to the Canoui-Poitrine classification. Patients were treated according to European S1 guidelines on HS.</p><p><strong>Conclusions: </strong>This is the first study to evaluate subclinical DC findings in HS patients using trichoscopy. Although the trichoscopic findings of DC are heterogeneous, the use of this non-invasive technique, in conjunction with clinical evaluation, can improve diagnostic accuracy and lead to earlier diagnosis. These findings suggest a potential association between HS and DC, indicating the need for further studies to evaluate this relationship.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"275-279"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}