Skin Appendage Disorders最新文献

{"title":"Severe Penoscrotal Lymphedema in Hidradenitis Suppurativa: A Case Series.","authors":"Hilmi Kılgın, Fatma Zehra Diken, Seçil Vural, Zeynep Altan Ferhatoğlu","doi":"10.1159/000551470","DOIUrl":"https://doi.org/10.1159/000551470","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent painful nodules, abscesses, and sinus tracts in apocrine gland-bearing areas. Penoscrotal lymphedema represents a rare but devastating complication, predominantly affecting patients with longstanding Hurley stage III disease.</p><p><strong>Case presentation: </strong>We present 3 cases of severe penoscrotal lymphedema in middle-aged males with longstanding HS. Case 1 involved a 42-year-old smoker with 10-year HS history who developed progressive lymphedema with violaceous nodules and sinus tracts over 5 years. Case 2 involved a 45-year-old male with Fitzpatrick skin phototype IV and adolescent-onset HS who developed massive scrotal lymphedema with characteristic verrucous lymphostasis and adult-acquired buried penis over 8 years. Case 3 involved a 53-year-old male with 16-year HS history who developed massive penoscrotal lymphedema complicated by secondary (AA) amyloidosis with chronic kidney disease and proteinuria. All patients demonstrated profound quality of life impairment and underwent systematic exclusion of alternative etiologies. Treatment included systemic antibiotics and TNF-alpha inhibitors (adalimumab), with variable clinical response.</p><p><strong>Conclusion: </strong>These cases highlight the importance of early recognition as timely biologic therapy may prevent progression to irreversible complications requiring surgical intervention. Lymphedema in HS requires multidisciplinary management involving dermatology, plastic surgery, urology, nephrology, and psychological support services.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147942921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Trichoscopic Evaluation of Beard in Men with Frontal Fibrosing Alopecia: A Multicenter Prospective Study.","authors":"Corina Isabel Salas-Callo, Vitoria Azulay, David Saceda-Corralo, Leonardo Spagnol Abraham, Ana Melian Oliveira, Rafaella Lacerda Maia, Rita Fernanda Cortez de Almeida, Daniel Fernandes Melo, Sergio Vañó-Galván, Antonella Tosti, Rodrigo Pirmez","doi":"10.1159/000551425","DOIUrl":"10.1159/000551425","url":null,"abstract":"<p><strong>Introduction: </strong>Frontal fibrosing alopecia (FFA) is a scarring alopecia first described in 1994. It is more common in postmenopausal women, and its incidence has increased significantly among both premenopausal and postmenopausal women. FFA is less frequent in men and beard involvement occurs in 50-74% of male FFA patients. This study aimed to assess the clinical and trichoscopic features of beard involvement in FFA patients.</p><p><strong>Methods: </strong>After the Institutional Review Board's approval, a prospective multicenter study was conducted involving 25 male patients with FFA. Clinical photos were taken and trichoscopic images of 5 areas (sideburns, right-left lateral cheek, mustache, and chin) were obtained.</p><p><strong>Results: </strong>Beard hair loss was observed in all patients. Severe clinical involvement was associated with the presence of facial papules and with numerous concomitant (≥3) features (facial papules; lichen planus pigmentosus; loss of eyebrows, eyelashes, or body hair). Trichoscopic findings were present in all patients. Absence of follicular openings (100%), black dots (64%), perifollicular erythema (56%), broken hairs (56%), telangiectasias (56%), and white dots (48%) were the most prevalent findings.</p><p><strong>Conclusion: </strong>Clinical and trichoscopic beard involvement in male FFA were observed in all patients, and severe involvement including all areas of the beard was observed in half of the patients. The high incidence of facial papules and body hair loss may indicate a more severe clinical profile in men.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Proteome-Driven Identification of Druggable Immune Regulators of Alopecia Areata, Validated by Transcriptome and Single-Cell Mapping.","authors":"Lingfeng Pan, Caihong Li, Liehao Yang","doi":"10.1159/000551293","DOIUrl":"10.1159/000551293","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an autoimmune hair-loss disorder driven by aberrant T-cell activation and immune-epithelial crosstalk. To identify actionable upstream regulators, we established a proteome-anchored multi-omics framework integrating genetic instruments, lesional transcriptomics, and single-cell immune profiling.</p><p><strong>Methods: </strong>Putative causal plasma proteins were prioritized using cis-protein quantitative trait loci-based inference across two large proteomic datasets (UKB-PPP and deCODE). Candidates were validated by differential expression in AA lesions, protein-interaction networks, and cell-type-resolved expression from scalp single-cell RNA-seq. Druggability was assessed using curated pharmacological resources, and PheWAS evaluated safety-relevant pleiotropy.</p><p><strong>Results: </strong>The pipeline identified 206 and 169 AA-associated proteins, with CD28, GZMB, and CD1C emerging as convergent immune regulators. Single-cell data showed enrichment of CD28⁺ effector T cells and CD1C⁺ myeloid subsets in lesions, linking circulating protein signals with local inflammation. Transcriptomic patterns implicated IL-2-modulated CD28 signaling and antihistamine-responsive pathways. Druggability analyses highlighted belatacept, a CD28-blocking biologic, while PheWAS indicated minimal adverse-phenotype enrichment.</p><p><strong>Conclusion: </strong>This proteome-driven framework uncovers druggable immune regulators of AA, positioning CD28 as an actionable target with a favorable safety profile and providing a generalizable strategy for autoimmune target discovery.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Onychomycosis on Quality of Life: A Cross-Sectional Study Using the Dermatology Life Quality Index.","authors":"Dalel Kemicha, Maha Lahouel, Sana Mokni, Najet Ghariani, Mohamed Denguezli","doi":"10.1159/000551412","DOIUrl":"https://doi.org/10.1159/000551412","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is a common nail disorder that can impair patients' quality of life (QoL). This study aimed to assess the impact of onychomycosis on QoL.</p><p><strong>Methods: </strong>QoL was evaluated using the Dermatology Life Quality Index (DLQI). Diagnosis was confirmed by microscopy and culture. Clinical features were recorded.</p><p><strong>Results: </strong>Forty patients were included (mean age 52.6 years; 70% female). Trichophyton species were found in 62.5%, Candida in 32.5%, and both in 5%. The mean DLQI was 6.1, indicating moderate impact. Women had higher scores than men (6.68 vs. 4.75; <i>p</i> = 0.03). Total nail involvement and combined fingernail/toenail infection were linked to greater QoL impairment (<i>p</i> < 0.05). The \"symptoms and feelings\" domain was higher in women (<i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Onychomycosis moderately impairs QoL, especially in women and patients with extensive nail involvement.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Scalp: Bilateral Hand Trichoteiromania Revealed by Trichoscopy - A Case Report.","authors":"Eduardo Corona-Rodarte, Juan Jimenez-Cauhe, Daniel Fernandes-Melo, Antonella Tosti, Daniel Asz-Sigall","doi":"10.1159/000551364","DOIUrl":"https://doi.org/10.1159/000551364","url":null,"abstract":"<p><strong>Introduction: </strong>Trichoteiromania is a friction-induced hair shaft disorder caused by repetitive rubbing/scratching and is often considered the hair shaft expression of lichen simplex chronicus (\"scratching-pseudo-alopecia\"). It is classically described on the scalp and presents with lichenified plaques and characteristic trichoscopy such as broom hairs and V-hairs. Pruritus or an urge to rub is common and may help distinguish it from trichotillomania (hair pulling), which is often asymptomatic. To date, the condition has been described almost exclusively as a scalp disorder.</p><p><strong>Case presentation: </strong>We report a 55-year-old man working in finance with a 15-year history of asymptomatic skin changes on the dorsal hands, initially unilateral and later bilateral, who was referred because of concern about malignancy. Examination revealed symmetric lichenified plaques with excoriations, erythema, haemorrhagic crusts, and numerous short broken hairs on the dorsal aspects of the index fingers and thumb, as well as bilateral enlarged lunulae of the thumbnails. Trichoscopy was diagnostic, showing broom hairs, V-shaped hairs, short broken hairs at different lengths, perifollicular and interfollicular scale, and irregular perifollicular brown pigmentation, consistent with trichoteiromania. No biopsy was required. The patient was reassured regarding the benign nature of the condition, started on topical urea and clobetasol, and referred for psychiatric follow-up to address the underlying compulsive rubbing behaviour.</p><p><strong>Conclusion: </strong>This case represents, to our knowledge, the first description of trichoteiromania affecting a non-scalp site and demonstrates that its full trichoscopic signature can occur on extracranial hair-bearing skin. This case expands the anatomical spectrum of trichoteiromania beyond the scalp and highlights trichoscopy as a rapid, non-invasive tool to attribute hair shaft damage to chronic friction.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy-Induced Scarring Alopecia: A Case Series.","authors":"Dorsaf Elinkichari, Karama Sboui, Marie Donzel, Emmanuel Ribereau-Gayon, Rima Fathallah, Stéphane Dalle","doi":"10.1159/000551409","DOIUrl":"10.1159/000551409","url":null,"abstract":"<p><strong>Introduction: </strong>Over the last decade, immune checkpoint inhibitors (ICIs) have revolutionized the management of advanced cancers. Immune-induced alopecia has occasionally been reported, with alopecia areata being the most frequently described form, whereas scarring alopecia remains rarely documented. We report a case series of scarring alopecia occurring in patients treated with ICIs for metastatic melanoma.</p><p><strong>Case presentation: </strong>We conducted a descriptive study with retrospective data collection from January 2023 to December 2025. We enrolled 450 patients who were treated with checkpoint inhibitors for metastatic melanomas. Six patients developed scarring alopecia which corresponds to a prevalence of 1.33%. Because of lack of data, only four cases are described in this paper. All patients were female. The mean age at onset of hair fall was 64 years (51-82). None had a previous history of alopecia. The mean duration to symptoms onset after treatment initiation was 29.25 months (26-48). Alopecia did not lead to discontinuation of treatment in none of our patients. All patients had other immune-related adverse events. Cancer outcome was favourable in all patients with at least partial remission.</p><p><strong>Conclusion: </strong>Characterizing immune-induced alopecia, particularly scarring alopecia, is crucial for informing patients about the potential psychological impact of hair loss in an oncological context. Furthermore, the possible association between therapeutic efficacy and follicular toxicity warrants further investigation.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Healthcare Utilization in Hidradenitis Suppurativa and Arthritis: A Propensity Score-Matched Analysis from a Hospital-Based Cohort.","authors":"Patricia Garbayo-Salmons, Albert Rodrigo-Parés, Ester Saus, Mireia Moreno, Anna Carreras, Clara Feliu-Hernàndez, Vicente Exposito-Serrano, Miquel Ribera, Mireia Sabat, Joan Calvet","doi":"10.1159/000551410","DOIUrl":"10.1159/000551410","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) has been linked to arthritis, but large real-world analyses remain limited. This study evaluated the prevalence, risk, and clinical impact of arthritis in patients with HS, focusing on healthcare use.</p><p><strong>Methods: </strong>A retrospective multicenter cohort was assembled using the TriNetX network. Adults with HS (<i>n</i> = 226,047) were compared with matched controls without HS (<i>n</i> = 12,286,573). Arthritis prevalence, 5-year risk, and healthcare utilization were assessed after 1:1 propensity score matching.</p><p><strong>Results: </strong>Arthritis prevalence was higher in the HS group (6.22% vs. 5.66%). Over 5 years, HS patients had a higher risk of arthritis than the general hospital population (2.22% vs. 1.73%; risk ratio 1.29, 95% CI: 1.23-1.34). Within the HS cohort, those with arthritis showed greater use of systemic therapies, including tumor necrosis factor inhibitors (27% vs. 6%) and interleukin inhibitors (12% vs. 2%). They also had more outpatient visits, emergency visits, and hospitalizations across 1-, 3-, and 5-year periods.</p><p><strong>Conclusions: </strong>Findings should be interpreted considering the limitations of administrative datasets, including potential misclassification and underreporting. Overall, HS is associated with a higher 5-year risk (cumulative incidence) of arthritis, and patients with both conditions exhibit substantially increased healthcare use.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Hair Cosmetics: Physiology, Safety, and Product Considerations.","authors":"Hector Cantu-Maltos, Lorena Bojalil, Luz Orozco-Covarrubias, Maria Teresa García-Romero, Carolina Guadalupe Palacios López, Marimar Saez-de-Ocariz","doi":"10.1159/000551190","DOIUrl":"10.1159/000551190","url":null,"abstract":"<p><strong>Background: </strong>Pediatric hair care has particular challenges due to differences between children's hair and scalp and those of adults in physiology, structure, and barrier function. These differences support the need for evidence-based hair care.</p><p><strong>Summary: </strong>This narrative review synthesizes current knowledge on pediatric hair physiology, hair shaft structure, and the use of common hair products. Central physiologic aspects include lower sebum production, age-dependent changes in hair density, and structure-related variability among hair types. Age-related variations influence how hair care products interact with the hair shaft and scalp. We describe the main categories of hair cosmetics, addressing their classification, mechanisms of action, and ingredient effects on pediatric hair. Safety considerations include ocular tolerance, allergen and irritant potential, and concerns regarding endocrine-disrupting chemicals. Although individual ingredient exposure appears to be low, cumulative exposure and long-term effects remain insufficiently studied. Finally, we address cosmetic regulations in the USA and the European Union, noting the absence of age-specific policies. In this context, pediatric hair care should be need- and function-oriented rather than routine-driven.</p><p><strong>Key messages: </strong>Pediatric hair care requires gentle formulations with controlled pH, minimal irritant potential, and avoidance of sensitizing ingredients. Limited pediatric safety evidence highlights the need for clearer regulations and child-focused research.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Comorbidities in Pseudofolliculitis Barbae: A Cross-Sectional Study of the All of Us Database.","authors":"Christine Olagun-Samuel, Rohan Ahuja, Sophia Manduca, Soutrik Mandal, Steven Friedman, Zasca-Aisha Ristianto, Prince Adotama","doi":"10.1159/000551294","DOIUrl":"10.1159/000551294","url":null,"abstract":"<p><strong>Introduction: </strong>Pseudofolliculitis barbae (PFB) is a chronic inflammatory condition of hair follicles characterized by inflamed papules and pustules, with increased risk in individuals with curly or coarse hair. While psychiatric comorbidities in acne are well studied, limited research exists on PFB's psychological impact.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of individuals with PFB using the <i>All of Us</i> dataset, which includes EHR data from US adults since 2018.</p><p><strong>Results: </strong>A total of N = 1,668 individuals were included in the matched dataset, with 834 PFB cases and 834 controls and were assessed for diagnosis of attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), major depressive disorder (MDD), and general anxiety disorder (GAD). The association between the presence of ADHD and PFB was significant (<i>p</i> value = 0.009). Similarly, the presence of GAD (23% of PFB patients and 10% of patients without PFB) and MDD (48.4% of PFB patients and 26.3% of patients without PFB) was significantly associated with the presence of PFB (<i>p</i> value <0.001 for both conditions). However, OCD was found not to be significantly associated with the presence of PFB (<i>p</i> = 0.15).</p><p><strong>Discussion: </strong>Our study demonstrated a significant association between PFB and mood disorders like depression or anxiety. Future studies should examine PFB severity and treatment efficacy on psychological outcomes.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychoscopic Alterations in Newborns with Early Congenital Syphilis: A Single-Center Cross-Sectional Study of 10 Cases.","authors":"Cuauhtli Emmanuel Arambul-Carrillo, Rocío Concepción Albores-Arguijo, Andrea Biviana Ruíz-Leal, Nicole Orendain-Koch, Melisa Rivera, Xochitl Valenzuela-Barba","doi":"10.1159/000551006","DOIUrl":"10.1159/000551006","url":null,"abstract":"<p><strong>Introduction: </strong>Early congenital syphilis (ECS) is a vertically transmitted infection that remains difficult to diagnose in the neonatal period, as many newborns are asymptomatic at birth. Although mucocutaneous manifestations are well recognized, nail involvement has been rarely described.</p><p><strong>Methods: </strong>We conducted a prospective, single-center study including neonates with ECS fulfilling scenario 1 or 2 criteria established by the Centers for Disease Control and Prevention and the American Academy of Pediatrics. Ten neonates admitted to the neonatal intensive care unit between April and July 2025 were enrolled. Systematic onychoscopy (10×) of all 20 nails was performed. Findings were analyzed according to serum Venereal Disease Research Laboratory (VDRL) titers, comparing group 1 (<1:128) and group 2 (≥1:128 or prozone phenomenon).</p><p><strong>Results: </strong>The most frequent abnormalities were onycholysis and onychoschizia (100%), herringbone nail pattern (80%), and periungual scaling (90%). Mega lunula and anonychia (40% each) were significantly associated with VDRL titers ≥1:128 and/or prozone phenomenon (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Mega lunula and anonychia may serve as clinical markers of ECS in neonates with high VDRL titers, supporting onychoscopy as a complementary diagnostic tool.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}