Skin Appendage Disorders最新文献

Giant Cell Tumor of Flexor Tendon Sheath: An Interesting Clinical Presentation as Subungual Growth.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-13 DOI: 10.1159/000540487

Chander Grover, Pratibha Gupta, Rajesh Arora, Pragya Jain

引用次数: 0

Hairbrushes: A Guide for Dermatologists.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-12 DOI: 10.1159/000540486

Kimberly N Williams, Juwon Lee, Esthefani Robles, Antonella Tosti

引用次数: 0

Drug-Induced Hair Loss: Analysis of the Food and Drug Administration's Adverse Events Reporting System Database.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-07-29 DOI: 10.1159/000540104

Rachel C Hill, Steven D Zeldin, Shari R Lipner

{"title":"Drug-Induced Hair Loss: Analysis of the Food and Drug Administration's Adverse Events Reporting System Database.","authors":"Rachel C Hill, Steven D Zeldin, Shari R Lipner","doi":"10.1159/000540104","DOIUrl":"10.1159/000540104","url":null,"abstract":"Introduction: Drug-induced hair loss is one of several causes of hair loss commonly seen in clinical practice, and it is often a daunting task to determine a potential culprit drug when a patient is taking numerous medications. Our objective was to identify drugs responsible for hair loss, using the Food and Drug Administration's Adverse Events Reporting System (FAERS) database, a compilation of drug-related adverse events (AEs).Methods: Using the FAERS database, we queried all domestic reports with the reaction term \"alopecia\" listed as an AE in patients ≥18 years old from April 1, 1968, to September 29, 2023. Using descriptive statistics, individual agents were grouped by drug class.Results: We analyzed a total of 39,346 hair loss AE reports related to a single agent. Immunomodulatory agents and monoclonal antibodies represented the highest proportion of AE reports for alopecia, followed by hair loss drugs, contraceptives, and antitumor necrosis factor (anti-TNF) biologics.Conclusion: In sum, we showed that immunomodulatory agents and monoclonal antibodies, hair loss drugs, including minoxidil and finasteride, contraceptives, kinase inhibitors, and anti-TNF drugs are most frequently associated with hair loss AEs in the FAERS database. Because many of these drugs are not prescribed primarily for dermatologic indications, our study provides guidance for dermatologists in identifying common medications associated with alopecia.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"63-69"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and Safety of Intramatricial Triamcinolone Acetonide for Trachyonychia: A Retrospective Data Analysis.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-09-03 DOI: 10.1159/000540703

Chander Grover, Bharti Aggarwal, Subhojit Ray

{"title":"Effectiveness and Safety of Intramatricial Triamcinolone Acetonide for Trachyonychia: A Retrospective Data Analysis.","authors":"Chander Grover, Bharti Aggarwal, Subhojit Ray","doi":"10.1159/000540703","DOIUrl":"10.1159/000540703","url":null,"abstract":"Introduction: Trachyonychia is a clinical presentation characterised by dry, rough, longitudinally ridged nails or opalescent shiny nail plates with pits. Intramatricial steroids are an accepted form of therapy, but efficacy data are lacking.Materials and methods: A retrospective data analysis of 6 patients (84 nails) with trachyonychia who received treatment for at least 6 sessions, with intramatricial triamcinolone acetonide (TA) (5 mg/mL), administered at 4 weekly intervals, was conducted. Photographic records were analysed for scoring severity of disease with Nail Surface Abnormality Index (NSI) score. Endpoint of therapy was 4 weeks after the sixth injection.Results: Among the 6 patients analysed as per protocol, 4 had both finger and toenails involved, while 2 had only fingernails affected. Overall 56/60 fingernails (93.3%) and 28/60 toenails (46.6%) were affected in these patients, and were treated. The mean baseline NSI score for fingernails was 10.34 ± 4.1 (range 2-16) which improved to 6.61 ± 3.21 (range 0-12 at endpoint, showing a 37.86% reduction [p < 0.0001]). The mean baseline NSI score of toenails improved from 10.25 ± 3.51 (range 4-14) to 5.00 ± 1.91 (range 1-8) at endpoint, showing a 50.05% reduction (p < 0.0001). Adverse effects included pain (5.88%), subungual hematoma (5.88%), proximal nail fold hyperpigmentation (21.17%), and atrophy (22.35%).Conclusion: Intramatricial TA is a safe and effective modality for treating trachyonychia.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"74-79"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Insights Malalignment or Retronychia: Which Comes First?

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-08 DOI: 10.1159/000540488

André Lencastre, Bertrand Richert

引用次数: 0

Patient Characteristics, Diagnostic Testing Utilization, and Antifungal Prescribing Pattern for Onychomycosis in the USA: A Cohort Study Using DataDerm, 2016-2022.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-29 DOI: 10.1159/000540704

Aditya K Gupta, Tong Wang, Anh N Tran

{"title":"Patient Characteristics, Diagnostic Testing Utilization, and Antifungal Prescribing Pattern for Onychomycosis in the USA: A Cohort Study Using DataDerm, 2016-2022.","authors":"Aditya K Gupta, Tong Wang, Anh N Tran","doi":"10.1159/000540704","DOIUrl":"10.1159/000540704","url":null,"abstract":"Introduction: Onychomycosis is a complex nail disease that is commonly seen in daily practice.Methods: Electronic health records of clinically diagnosed onychomycosis patients were extracted using DataDerm - a dermatology data registry hosted by the American Academy of Dermatology - spanning from the year 2016 to 2022.Results: Regardless of age, an increasing trend in patient volume was observed in the Southern US region, which accounted for 50.7-56.9% of onychomycosis patients in 2022. A coinfection of tinea pedis was present among 15.6-22.5% of patients. Diagnostic testing was infrequently utilized with less than one-quarter of patients having a histopathologic examination (12.7-21.9%) followed by fungal culture (5.5-8.2%) and direct microscopic examination (3.3-6.0%). Treatments were infrequently prescribed, accounting for less than one-quarter of patients (orals, terbinafine: 20.8-29.1%, fluconazole: 12.9-16.5%; topicals, efinaconazole: 3.2-13.8%); over 30% of treated patients received a combination regimen or experienced switching of treatments. Prescribing patterns did not significantly differ in vulnerable patient groups such as elderly patients and in patients with concomitant tinea pedis. Patients receiving a topical and/or oral antifungal prescription were frequently not tested to confirm the onychomycosis diagnosis (76.9%).Conclusion: Our findings add to a growing body of literature calling for the improvement of onychomycosis management practices.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"36-44"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sisaipho Revisited: Inverse Ophiasis or More than That?

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-12 DOI: 10.1159/000540489

Alexandros Katoulis, Georgia Pappa, Effie Markou, Antonios Kanelleas, Evangelia Bozi, Dimitrios Sgouros, Dimitris Rigopoulos, Lidia Rudnicka

引用次数: 0

Secondary Cutis Verticis Gyrata Induced by Long-Term Use of High-Dose Topical Minoxidil.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-22 DOI: 10.1159/000540243

Juste Baksanskaite, Natalia Caballero Uribe, Ralph M Trüeb

{"title":"Secondary Cutis Verticis Gyrata Induced by Long-Term Use of High-Dose Topical Minoxidil.","authors":"Juste Baksanskaite, Natalia Caballero Uribe, Ralph M Trüeb","doi":"10.1159/000540243","DOIUrl":"10.1159/000540243","url":null,"abstract":"Introduction: Cutis verticis gyrata (CVG) is a medical condition that is characterized by thickening of the scalp giving the scalp a cerebriform appearance. Due to an apparent paucity of the condition, limited research exists, and causes are as yet undetermined. What is known, is that the condition may either be a feature of several syndromes or occur as a consequence of a number of diseases or drugs that produce changes in scalp structure, particularly acromegaly, and theoretically, the use of growth hormone (GH) itself or the use of drugs that mimic the effect of GH (secretagogues).Case presentation: We present a case of CVG that resulted from long-term topical use of minoxidil at a high concentration.Discussion and conclusion: Minoxidil has been shown to be able to potentiate the mitogenic effects of insulin-like growth factor (IGF-1). Meanwhile, the striking manifestations of acromegaly are due to excessive IGF-1 production by the liver in response to GH stimulation. The growth-promoting properties of IGF-1 trigger soft tissue hypertrophy, and hypertrichosis. Pseudoacromegaly has been reported to be induced by the long-term use of oral minoxidil. This is the first case report of secondary CVG from the use of topical minoxidil for the treatment of male androgenetic alopecia.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"93-97"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circumscribed Alopecia Areata Incognita and Response to Tofacitinib.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-09-03 DOI: 10.1159/000540778

Mayra A Reyes Soto, Rodrigo Pirmez

{"title":"Circumscribed Alopecia Areata Incognita and Response to Tofacitinib.","authors":"Mayra A Reyes Soto, Rodrigo Pirmez","doi":"10.1159/000540778","DOIUrl":"10.1159/000540778","url":null,"abstract":"Introduction: Alopecia areata incognita (AAI) remains a subject of ongoing debate in the literature, with some authors advocating its classification as a subtype of alopecia areata. A localized form of this condition, entitled circumscribed AAI, has been rarely reported in the literature. We report an unusual case of circumscribed AAI treated with oral tofacitinib.Case report: A 21-year-old woman presented with a large patch of localized hair thinning on the parietal area. Trichoscopy revealed yellow dots and short thin hairs. A diagnosis of circumscribed AAI was established. Due to the frequent relapses to conventional treatment and associated weight gain secondary to oral dexamethasone, oral tofacitinib 5 mg twice daily was started with a sustained response.Discussion: AAI is a controversial condition, and its circumscribed variant is scarcely reported in the literature. We hypothesize that AAI clinical presentation may be secondary to cycle disturbance leading to rapid and incomplete hair follicle cycling. Most papers established that the best treatment for AAI is corticosteroids, either topical, intralesional or systemic.Conclusion: Oral tofacitinib represents a potential treatment for AAI cases that do not present a sustained response to corticosteroids.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"98-102"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Link: Trichostasis Spinulosa and Its Association with Early Phymatous Rosacea.

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-16 DOI: 10.1159/000540509

Sechi Andrea, Mariano Luca, Galvan Arturo

{"title":"Exploring the Link: Trichostasis Spinulosa and Its Association with Early Phymatous Rosacea.","authors":"Sechi Andrea, Mariano Luca, Galvan Arturo","doi":"10.1159/000540509","DOIUrl":"10.1159/000540509","url":null,"abstract":"Introduction: Rosacea is a chronic inflammatory skin condition with several clinical subtypes, including phymatous rosacea, which is distinguished by thickened skin, enlarged pores, and irregular surface nodularities, primarily affecting the nose. This manuscript aims to explore the underrecognized connection between early to moderate phymatous rosacea and trichostasis spinulosa (TS), a follicular disorder characterized by the retention of multiple telogen hairs.Methods: A total of consecutive 13 patients with initial phymatous changes and black dilated openings were enrolled. Detailed dermatological assessments, including dermoscopy, were conducted to identify and confirm trichostasis spinulosa. Dermoscopy of the black openings confirmed the presence of hair tufts emerging from dilated follicular openings and plugs. Patients underwent minor procedures using a comedo extractor to remove the hair bundles.Results: All extracted follicular units showed typical characteristics of trichostasis spinulosa, including bundles of telogen hairs surrounded by a sebokeratinous plug.Conclusion: We postulate that the fibrotic processes characteristic of phymatous rosacea may promote the development of TS. Recognizing TS as an early indicator of phymatous rosacea could help prevent disease progression.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"9-13"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0