Skin Appendage Disorders最新文献

Insights and Recommendations from a Case-Control Study of Trichotillomania. 拔毛癖病例对照研究的见解和建议。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-10-01 Epub Date: 2025-02-12 DOI: 10.1159/000544184

Wenjianbin Zhou, Shenghao Xu

引用次数: 0

Dermatologic Implications of Glucagon-Like Peptide-1 Receptor Agonist Medications. 胰高血糖素样肽-1受体激动剂药物的皮肤病学意义。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-10-01 Epub Date: 2025-02-14 DOI: 10.1159/000544023

Olivia M Burke, Brianna Sa, David Alvarez Cespedes, Antonella Tosti

{"title":"Dermatologic Implications of Glucagon-Like Peptide-1 Receptor Agonist Medications.","authors":"Olivia M Burke, Brianna Sa, David Alvarez Cespedes, Antonella Tosti","doi":"10.1159/000544023","DOIUrl":"https://doi.org/10.1159/000544023","url":null,"abstract":"Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an innovative class of medications primarily used to manage type 2 diabetes and obesity. These agents not only improve glycemic control but also promote significant weight loss and reduce cardiovascular risk.Summary: GLP-1RAs are associated with various dermatologic effects, including injection-site reactions and immune-mediated responses such as hypersensitivity, urticaria, and bullous pemphigoid. \"Ozempic face,\" a term describing facial fat loss, has gained media attention due to its cosmetic implications. Additionally, hair loss, particularly in the form of telogen effluvium, has been observed, potentially linked to rapid weight loss from GLP-1RA use. Emerging evidence also highlights the therapeutic potential of GLP-1RAs in enhancing wound healing and treating inflammatory skin conditions like psoriasis.Key messages: With the increasing use of GLP-1RAs for weight management, clinicians should remain alert to dermatologic side effects and consider appropriate dermatologic consultations when needed. Further research is essential to optimize the safe and effective use of GLP-1RAs, ensuring therapeutic benefits are maximized while minimizing adverse dermatologic outcomes.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 5","pages":"416-423"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hurley Staging Training for Hidradenitis Suppurativa Patients: Comment. 化脓性汗腺炎患者的Hurley分期训练：评论。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-10-01 Epub Date: 2025-02-05 DOI: 10.1159/000544026

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated with Significant Changes in Alcohol Consumption: A Retrospective Study of 21,971 Patients. 低剂量口服米诺地尔治疗雄激素性脱发与饮酒的显著变化无关：一项21971例患者的回顾性研究

IF 1.3

Skin Appendage Disorders Pub Date : 2025-10-01 Epub Date: 2025-01-30 DOI: 10.1159/000543710

Michael M Ong, Zachary Neubauer, Shari R Lipner

引用次数: 0

Male Pattern Androgenetic Alopecia Linked to an Adrenal Tumor: A Case Report. 男性型雄激素性脱发与肾上腺肿瘤相关：1例报告。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-10-01 Epub Date: 2025-02-05 DOI: 10.1159/000543887

Maria Fernanda Figueroa Hernández, Marysol Macedo Perez, María Teresa Alonso de León, Cristina Berumen Glinz, Jimena Pérez Rubio, Maria Elisa Vega Memije, Daniel Asz Sigall, Carlos Barrera Ochoa

{"title":"Male Pattern Androgenetic Alopecia Linked to an Adrenal Tumor: A Case Report.","authors":"Maria Fernanda Figueroa Hernández, Marysol Macedo Perez, María Teresa Alonso de León, Cristina Berumen Glinz, Jimena Pérez Rubio, Maria Elisa Vega Memije, Daniel Asz Sigall, Carlos Barrera Ochoa","doi":"10.1159/000543887","DOIUrl":"https://doi.org/10.1159/000543887","url":null,"abstract":"Introduction: Androgenetic alopecia (AGA) is a type of hair loss that often manifests as male or female pattern baldness. In women, AGA resembling male pattern baldness can occur in conditions of hyperandrogenism, such as congenital adrenal hyperplasia or ovarian and adrenal tumors, which are exceedingly rare, occurring in approximately 0.2% of cases.Case presentation: We report a 62-year-old female exhibiting hair loss and hirsutism that began over a decade ago. The medical examination reveals hirsutism on the face, abdomen, and chest, and hair loss in the fronto-parieto-occipital region, with a male pattern distribution consistent with grade VII on the Hamilton scale. Trichoscopy revealed loss of follicular openings, single follicular units, miniaturized hairs, and perifollicular brown halo. Laboratory tests indicated a total testosterone level of 10.15 ng/mL. An abdominal CT scan revealed bilateral adrenal adenomas, which were subsequently treated with laparoscopic radical adrenalectomy.Conclusion: In postmenopausal women, a new-onset state of hyperandrogenism may lead to virilizing symptoms, such as male pattern alopecia, when testosterone levels exceed 5 nmol/L, necessitates immediate investigation to exclude an androgen-producing tumor, which typically normalizes swiftly within weeks post-surgery, while symptoms of androgen excess gradually diminish following the normalization of testosterone levels, as observed in our case. Identifying the cause of hyperandrogenism is crucial for treatment. Surgery remains the primary option for postmenopausal women with virilizing symptoms and androgen excess.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 5","pages":"445-449"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. 治疗脱发的草药：疗效和安全性综述。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-20 DOI: 10.1159/000542876

Azhar Ahmed, Azhar M Alali, Ebtesam Abdullah, Mohammed N Alharbi, Hamza M Alayoubi

{"title":"Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.","authors":"Azhar Ahmed, Azhar M Alali, Ebtesam Abdullah, Mohammed N Alharbi, Hamza M Alayoubi","doi":"10.1159/000542876","DOIUrl":"https://doi.org/10.1159/000542876","url":null,"abstract":"Background: Hair loss (HL) is a prevalent condition worldwide; it can affect both males and females of different age groups. Despite the availability of many conventional treatment options, these might be linked to causing different side effects, leading to a growing interest in natural and herbal remedies (HRs). This review aims to investigate the efficacy and safety of various HRs for HL and examine the current scientific evidence behind them.Summary: A literature search used several studies to identify relevant studies published up to March 2024. The search terms included HL, alopecia, HRs, and names of specific herbs such as rosemary, saw palmetto, onion juice, Korean red ginseng, pumpkin seed oil, azelaic acid, olive oil, coconut oil, henna, honey, rice bran extract, Ashwagandha, and amla. Studies have suggested potential benefits in promoting hair growth and treating various forms of HL. These remedies were found to be effective in different conditions, including androgenetic alopecia, telogen effluvium, and alopecia areata, through various mechanisms of action, including 5α-reductase inhibition, increased microcapillary blood flow, antioxidant effects, and modulation of the hair growth signaling pathways.Key messages: Natural and HRs show promise in treating HL. However, many of these studies have limitations such as lack of long-term follow-up, small sample sizes, and short treatment durations. Due to this variation in the quality of evidence, further well-designed randomized trials with larger sample sizes are required to confirm the efficacy of these HRs.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"360-371"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool. 应用疾病症状学指导中心性离心性瘢痕性脱发患者的治疗：C-CAT评分工具的介绍。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-02-20 DOI: 10.1159/000544777

Aasheen Qadri, Elizabeth Will, Crystal Aguh

{"title":"Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool.","authors":"Aasheen Qadri, Elizabeth Will, Crystal Aguh","doi":"10.1159/000544777","DOIUrl":"https://doi.org/10.1159/000544777","url":null,"abstract":"Introduction: Central centrifugal cicatricial alopecia (CCCA) is a progressive scarring alopecia. No disease activity scale exists, making assessment of therapeutic intervention difficult. This study introduces the CCCA Clinical Assessment Tool (C-CAT), a novel scale that quantifies symptom severity to facilitate tailored treatment and track disease progression.Methods: A retrospective review of patients with CCCA was assessed on degree of pruritus, erythema, pain, disease progression, and scalp resistance, each scored from 0 to 2, over the course of a minimum of 6 months of therapy.Results: Eighty-two patients were included. The average initial C-CAT score was 3.4, consistent with mild to moderate disease activity. After 6 months of treatment, 88% of patients had improvement in score, with 48% of all patients achieving remission. Intralesional kenalog injections and topical clobetasol were the most commonly used therapies. Patients required an average of 3.6 different treatments to achieve therapeutic response.Conclusion: The C-CAT provides a structured, quantitative method to assess CCCA severity, which facilitates tracking of disease improvement for the majority of patients with targeted therapy. While the subjective nature of some C-CAT components may lead to inter-rater variability, this tool promotes personalized, symptom-based treatment and supports clinicians and patients in understanding this complex condition.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"309-315"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intralesional Nail Infiltration. 指甲局部浸润。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-17 DOI: 10.1159/000543538

Laura Bertanha, Leandro Fonseca Noriega, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio

引用次数: 0

A Case-Control Study of Trichotillomania Patients Using a National Database. 使用国家数据库对拔毛癖患者进行病例对照研究。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-27 DOI: 10.1159/000543503

Aarushi K Parikh, Noah Musolff, Madeline Tchack, Babar Rao

{"title":"A Case-Control Study of Trichotillomania Patients Using a National Database.","authors":"Aarushi K Parikh, Noah Musolff, Madeline Tchack, Babar Rao","doi":"10.1159/000543503","DOIUrl":"https://doi.org/10.1159/000543503","url":null,"abstract":"Introduction: Trichotillomania (TTM) is a body-focused repetitive disorder linked to psychiatric comorbidities. Comprehensive studies mapping its associations with a range of conditions remain limited. This study examines TTMs associations with psychiatric, neurodevelopmental, substance-related, reproductive, and social factors using a national database.Methods: We performed a case-control study using the All of Us Research Program database. TTM cases (n = 40) were matched to controls (n = 400) based on age, sex, and ethnicity. Multivariate logistic regression was used to examine associations with comorbidities and lifestyle factors, controlling for demographic variables.Results: TTM was significantly associated with obsessive-compulsive disorder (odds ratio [OR] 18.3), borderline personality disorder (OR 15), anxiety disorders (OR 10.2), alcohol abuse (OR 6.13), depression (OR 5.89), and vitamin D deficiency (OR 4.2) (all p < 0.01). Other significant associations included fatigue, social anxiety, post-traumatic stress disorder, ADHD, and difficulty running errands alone.Conclusion: Our findings highlight the strong association between TTM and a wide range of psychiatric and behavioral conditions, emphasizing the need for integrated treatment strategies addressing both psychiatric and physical aspects.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"379-384"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Practices of Subspecialty Nail Clinics: Results of a Survey of the Members of the Council for Nail Disorders. 亚专科指甲诊所的现行做法：指甲疾病理事会成员调查的结果。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-13 DOI: 10.1159/000543535

Safinaz Soliman, Phoebe Rich, Molly A Hinshaw

{"title":"Current Practices of Subspecialty Nail Clinics: Results of a Survey of the Members of the Council for Nail Disorders.","authors":"Safinaz Soliman, Phoebe Rich, Molly A Hinshaw","doi":"10.1159/000543535","DOIUrl":"https://doi.org/10.1159/000543535","url":null,"abstract":"Introduction: Knowledge of the structure and function of existing nail clinics remains limited. Sharing this knowledge from nail experts who run these clinics can readily support newly trained nail clinicians in setting up their nail clinics.Method: We surveyed members of the Council for Nail Disorders (CND) to learn about the structure and practices of their nail clinics. Of the practicing CND members in any membership class, we analyzed responses from those who have nail clinics.Results: Of the 79 practicing CND members, 38 responded (48.1% response rate), of whom 25 (65.8%) had a nail clinic. Analysis of these 25 responses revealed that 52% of nail clinics were relatively new (operating <5 years). The majority (72%) were in academic settings. Medical trainees were being taught in 64% of clinics. Nail clinics were directed by either one (64%) or multiple clinicians. All experts reported using clinical photographs in their routine care for nail patients, and 96% used dermoscopy. Additionally, 96% performed punch and tangential shave biopsies, and 88% performed matrixectomy. Access to a pathologist(s) with nail expertise was available in 84% of clinics.Conclusion: Our findings characterize the current practices of nail clinics directed by CND members, serving as a guide for clinicians looking to establish their own.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"372-378"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0