{"title":"Trichoscopy of Discoid Lupus Erythematosus in Caucasian Scalp: A Review.","authors":"Elisa Milan, Roberta Vezzoni, Michela V R Starace","doi":"10.1159/000539189","DOIUrl":"10.1159/000539189","url":null,"abstract":"<p><strong>Background: </strong>Scalp discoid lupus erythematosus in Caucasians is still a rare disease with a variable clinical presentation. Its dermoscopic characteristics are poorly described in literature, especially in the white population. The aim of this review was to critically analyze published papers on this topic and summarize relevant features.</p><p><strong>Summary: </strong>A comprehensive search for eligible articles was conducted in the databases of MEDLINE/PubMed. Results were analyzed following dermoscopic patterns such as follicular openings, hair shafts, perifollicular surface, and vessel pattern.</p><p><strong>Key messages: </strong>The most representative features appeared the absence of follicular openings and the presence of follicular keratotic plugs, along with yellow-brown and red dots. In long-lasting lesions with chronic stage, trichoscopy showed the absence of follicular openings, white or milky red cicatricial patches, white and brown structureless areas, and thick arborizing vessels.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"We Need to Nail It: Dermatology Resident Survey Highlighting Lack of Education for Nail Matrix Biopsies","authors":"A. C. Gamret, Ella Glaser, Brian W. Morrison","doi":"10.1159/000540490","DOIUrl":"https://doi.org/10.1159/000540490","url":null,"abstract":"Introduction: Dermatologists are experts in the skin, hair, and nails. However, it is the authors’ perception that many dermatologists lack comfort in performing nail matrix biopsies. Methods: Concerned for inadequate training, we surveyed US dermatology residents to assess their exposure to this procedure. Results: Of the 130 respondents, 43 were PGY4 residents. Of these, 37.21% had never observed and 62.79% had never performed a nail matrix tangential shave biopsy. Similarly, 32.56% had never observed and 58.14% had never performed a nail matrix punch biopsy. Overall, 83.8% of all residents did not feel comfortable with and 71.5% did not anticipate feeling comfortable with performing nail matrix biopsies by residency completion. Interestingly, size of the training program and presence of a nail expert at the institution did not increase comfort levels in performing nail matrix biopsies (p = 0.348 and p = 1.0, respectively). Additionally, the presence of a nail expert did not affect the number of biopsies observed or performed by residents. The only statistically significant associations were between year of training (p < 0.001) and having a formalized curriculum and comfort with nail matrix biopsies (p = 0.002). Conclusions: Our survey highlights a potential lack of instruction in performing nail matrix biopsies in US dermatology residencies and calls for improved resident education.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michela Valeria Rita Starace, Aditya K Gupta, Mary A Bamimore, Mesbah Talukder, Federico Quadrelli, Bianca Maria Piraccini
{"title":"The Comparative Effects of Monotherapy with Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women with Pattern Hair Loss: A Retrospective Cohort Study.","authors":"Michela Valeria Rita Starace, Aditya K Gupta, Mary A Bamimore, Mesbah Talukder, Federico Quadrelli, Bianca Maria Piraccini","doi":"10.1159/000538621","DOIUrl":"10.1159/000538621","url":null,"abstract":"<p><strong>Introduction: </strong>Oral finasteride and topical minoxidil are long-standing androgenetic alopecia (AGA) treatments; topical finasteride is a more recent medicine. Few studies have compared their therapeutic effects in postmenopausal women. We compared the therapeutic impact of topical finasteride (1-4 sprays of 0.25% topical finasteride solution daily for 12 months), oral finasteride (2.5 mg oral finasteride once daily for 12 months), and topical minoxidil (1 mL of topical minoxidil 5% twice daily for 12 months) in postmenopausal women with AGA.</p><p><strong>Methods: </strong>We conducted Bayesian network meta-analyses of individual patient-level data insofar as four clinically relevant endpoints, namely, 12-month change in (1) total hair density, (2) hair diameter, (3) clinical photographs, and (4) patients' opinion of efficacy. Data were obtained through medical charts. Regimens' surface under the cumulative ranking distribution (SUCRA) values and relative effects - as per odds ratios - were computed.</p><p><strong>Results: </strong>As per SUCRA, the most and least effective regimens - across the four outcomes - were oral finasteride, and topical finasteride, respectively; however, no significant statistical differences were found (i.e., <i>p ></i> 0.05).</p><p><strong>Conclusion: </strong>Oral finasteride is ranked more effective than the topical forms of minoxidil and finasteride; however, more studies are needed to confirm this result.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Piquero-Casals, D. Saceda-Corralo, S. Aladren, Javier Bustos, Alfonso Fernández-Botello, Albert Navasa, Georgina Logusso, Eric Jourdan, J. Mir-Bonafé, Daniel Morgado-Carrasco
{"title":"Oral Supplementation with l-Cystine, Serenoa repens, Cucurbita pepo, and Pygeum africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study","authors":"J. Piquero-Casals, D. Saceda-Corralo, S. Aladren, Javier Bustos, Alfonso Fernández-Botello, Albert Navasa, Georgina Logusso, Eric Jourdan, J. Mir-Bonafé, Daniel Morgado-Carrasco","doi":"10.1159/000540081","DOIUrl":"https://doi.org/10.1159/000540081","url":null,"abstract":"Introduction: Chronic telogen effluvium (TE) and androgenetic alopecia represent two prevalent forms of hair loss that can significantly impact individuals’ quality of life. Insufficiency of essential micronutrients has been associated with hair loss. The objective of this study was to evaluate the safety and efficacy of an oral supplement containing l-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, and micronutrients in chronic TE (CTE) and androgenetic alopecia (AGA). Methods: Eighty patients of both sexes aged 18–60 years with CTE or AGA were randomized to receive one capsule daily of the oral supplement or placebo for 6 months. Dermatological evaluations, clinical pictures and phototrichograms were done at baseline, 3 months and 6 months. The overall hair volume and appearance were assessed before and after treatment as well as subject’s self-assessment via standardized questionnaire. Results: Hair density increased by 9.9 hairs/cm2 after 3 months and 12.3 hairs/cm2 after 6 months in the oral supplement group and it is statistically significant when compared to placebo. Overall hair volume after 1, 3, and 6 months is better in the supplement group than in the placebo group. The oral supplement was well tolerated. No moderate or severe adverse events were reported. Conclusion: Oral supplementation can increase hair density, anagen hairs, and overall hair appearance in patients with AGA or CTE.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Side Effects’ Frequency Assessment of Low Dose Oral Minoxidil in Male Androgenetic Alopecia Patients","authors":"Leila David Bloch, Rafaelly Mayara Dantas Carlos","doi":"10.1159/000539969","DOIUrl":"https://doi.org/10.1159/000539969","url":null,"abstract":"Introduction: Hair loss is a very common complaint in dermatologists’ offices, requiring the use of proven safe and effective therapies to improve the condition without jeopardizing patients’ health and well-being. Methods: We selected 100 male patients with androgenetic alopecia beginning treatment with low dose oral minoxidil to observe incidence and frequency of side effects. Results: The side-effects/symptoms observed in the assessed patients included body and facial hypertrichosis (most incidents), lower legs edema, periorbital edema, fatigue, tachycardia, and insomnia. Dizziness, hypotension, respiratory changes, and diarrhea were expected although not found in the assessed participants. No life-threatening adverse effects were observed. Conclusion: The doses administered in current research of oral minoxidil presented good safety profile as hair loss treatment, with the most incident side-effect being related to hypertrichosis. Systemic side-effects were infrequent.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141811101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitris Rigopoulos, A. Tsiogka, Dimitrios Malanos, S. Gregoriou
{"title":"What Is New in Nail Psoriasis?","authors":"Dimitris Rigopoulos, A. Tsiogka, Dimitrios Malanos, S. Gregoriou","doi":"10.1159/000539727","DOIUrl":"https://doi.org/10.1159/000539727","url":null,"abstract":"Background: Nail involvement is very frequent in psoriasis and may significantly affect patients’ quality of life due to clinical and functional impairment. In addition, nail psoriasis constitutes a negative prognostic factor for the development of psoriatic arthritis (PsA), even in the absence of cutaneous disease. Summary: Herein we provide an updated review on the diagnostic evaluation of nail psoriasis using clinical assessment and implementation of imaging techniques including dermoscopy, capillaroscopy, ultrasonography, and optical coherence tomography. In addition, we summarize consensus guidelines for the management of nail psoriasis and provide efficacy data on the use of intralesional, topical, and the most recently approved targeted systemic therapies. Key Messages: Physicians should be aware of the importance of prompt diagnosis and management of nail psoriasis, to improve patient outcomes and decrease the risk of PsA development.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aditya K. Gupta, Daniel Taylor, Shruthi Polla Ravi, Tong Wang, M. Talukder
{"title":"Treatments for Onychomycosis: A Bibliometric Analysis","authors":"Aditya K. Gupta, Daniel Taylor, Shruthi Polla Ravi, Tong Wang, M. Talukder","doi":"10.1159/000539822","DOIUrl":"https://doi.org/10.1159/000539822","url":null,"abstract":"Introduction: Oral antifungals were the earliest treatments to receive approval for the management of onychomycosis and have a long-standing record to support their efficacy. Topical antifungals and device-based treatments have been explored and some implemented in more recent years as alternatives to traditional oral antifungals. The present bibliometric analysis summarizes trends in publication frequency for onychomycosis treatment modalities over time and characterizes their body of literature in terms of types of studies available and relative level of evidence. Methods: A comprehensive literature search was performed using Web of Science and SCOPUS databases. Results: Covering all publications from 1970 to present day, our search identified oral therapeutics n = 295 articles (n = 63 randomized control trials [RCTs]), topical therapeutics n = 358 articles (n = 72 RCTs), and device-based treatments n = 158 articles (n = 37 RCTs). Spikes in research activity surround FDA approval of therapeutics for each treatment modality. Research activity within the last decade has focused on topical and device-based treatments. Evidence for efficacy of device-based treatments is lacking from relatively few high-quality RCTs. Conclusion: With growing concern for non-dermatophyte mold onychomycosis and terbinafine resistance, researchers should validate the efficacy and safety of device-based treatments with high-quality studies.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}