{"title":"低剂量口服米诺地尔治疗雄激素性脱发与饮酒的显著变化无关：一项21971例患者的回顾性研究","authors":"Michael M Ong, Zachary Neubauer, Shari R Lipner","doi":"10.1159/000543710","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Oral minoxidil, used off-label for androgenetic alopecia, has been linked to alcohol hangover symptoms. We examined changes in alcohol consumption before and after low-dose oral minoxidil (LDOM) initiation.</p><p><strong>Methods: </strong>Using Epic's Cosmos database (2010-2024), we analyzed alcohol consumption 6 months pre- and post-minoxidil in patients with recorded data. A two-sample <i>z</i> test compared average daily alcohol intake.</p><p><strong>Results: </strong>Among 21,971 patients, demographics and minoxidil dosing were similar between groups. Average alcohol consumption was unchanged pre- versus post-LDOM (0.264 vs. 0.260 drinks/day, <i>p</i> = 0.72).</p><p><strong>Conclusion: </strong>LDOM does not significantly affect alcohol consumption, suggesting minimal impact on hangover symptoms. Prospective studies are needed, but patients can be reassured about the low likelihood of symptom exacerbation.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 5","pages":"441-444"},"PeriodicalIF":1.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500294/pdf/","citationCount":"0","resultStr":"{\"title\":\"Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated with Significant Changes in Alcohol Consumption: A Retrospective Study of 21,971 Patients.\",\"authors\":\"Michael M Ong, Zachary Neubauer, Shari R Lipner\",\"doi\":\"10.1159/000543710\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Oral minoxidil, used off-label for androgenetic alopecia, has been linked to alcohol hangover symptoms. We examined changes in alcohol consumption before and after low-dose oral minoxidil (LDOM) initiation.</p><p><strong>Methods: </strong>Using Epic's Cosmos database (2010-2024), we analyzed alcohol consumption 6 months pre- and post-minoxidil in patients with recorded data. A two-sample <i>z</i> test compared average daily alcohol intake.</p><p><strong>Results: </strong>Among 21,971 patients, demographics and minoxidil dosing were similar between groups. Average alcohol consumption was unchanged pre- versus post-LDOM (0.264 vs. 0.260 drinks/day, <i>p</i> = 0.72).</p><p><strong>Conclusion: </strong>LDOM does not significantly affect alcohol consumption, suggesting minimal impact on hangover symptoms. Prospective studies are needed, but patients can be reassured about the low likelihood of symptom exacerbation.</p>\",\"PeriodicalId\":21844,\"journal\":{\"name\":\"Skin Appendage Disorders\",\"volume\":\"11 5\",\"pages\":\"441-444\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500294/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Skin Appendage Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000543710\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin Appendage Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000543710","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Low-Dose Oral Minoxidil for Androgenetic Alopecia Is Not Associated with Significant Changes in Alcohol Consumption: A Retrospective Study of 21,971 Patients.
Introduction: Oral minoxidil, used off-label for androgenetic alopecia, has been linked to alcohol hangover symptoms. We examined changes in alcohol consumption before and after low-dose oral minoxidil (LDOM) initiation.
Methods: Using Epic's Cosmos database (2010-2024), we analyzed alcohol consumption 6 months pre- and post-minoxidil in patients with recorded data. A two-sample z test compared average daily alcohol intake.
Results: Among 21,971 patients, demographics and minoxidil dosing were similar between groups. Average alcohol consumption was unchanged pre- versus post-LDOM (0.264 vs. 0.260 drinks/day, p = 0.72).
Conclusion: LDOM does not significantly affect alcohol consumption, suggesting minimal impact on hangover symptoms. Prospective studies are needed, but patients can be reassured about the low likelihood of symptom exacerbation.
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