{"title":"Update on Squamous Cell Carcinoma of the Nail Unit: An Human Papillomavirus-Associated Condition.","authors":"Eric R Bray, Antonella Tosti, Brian W Morrison","doi":"10.1159/000537760","DOIUrl":"10.1159/000537760","url":null,"abstract":"<p><strong>Background: </strong>Squamous cell carcinoma (SCC) and SCC in situ (Bowen's disease) are the most common malignancies of the nail unit. They are frequently seen in men over 50 and most commonly affect the fingers. The role of high-risk human papillomavirus (HPV) infection has been identified as a key contributor to the development of nail unit SCC.</p><p><strong>Summary: </strong>In this review, we aimed to summarize the current state of our understanding of how HPV contributes to nail unit SCC, the role of genitodigital transmission of HPV, and the clinical features of HPV-associated nail unit SCC. We also review current advances in the treatment of nail unit SCC, with a focus on the potential role of HPV vaccination in the treatment and prevention of nail unit SCC.</p><p><strong>Key messages: </strong>Nail unit SCC should be recognized as an HPV-associated disease. HPV vaccination may represent a non-surgical modality for the management of these challenging malignancies in the appropriate clinical setting.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 3","pages":"199-206"},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Growth Factors and Microneedling in Alopecia Areata: A Narrative Review","authors":"M. Almutlq, Abrar E. Bukhari","doi":"10.1159/000534636","DOIUrl":"https://doi.org/10.1159/000534636","url":null,"abstract":"Alopecia areata (AA) is an autoimmune condition that causes non-scarring hair loss on the scalp or other hair-bearing surfaces. Various signalling molecules regulate the hair cycle and hair follicle regeneration. These include genes, growth factors, nuclear receptors, cytokines, and subcellular signalling pathways. Growth factors can cause the vascular endothelium and dermal fibroblasts to proliferate, extend the anagen phase, and delay the initiation of catagen in the hair follicle, thereby promoting hair growth. Microneedling causes the release of growth factors and has been shown to help high-molecular-weight drugs penetrate the stratum corneum and hair follicles. These recent discoveries regarding the pathogenesis of AA have resulted in the development of promising therapies. Herein, this article reviews the use of growth factors and microneedling in the treatment of AA and explores their efficacy and safety. Treatment with growth factors and microneedling appears to be highly effective for AA, with no major adverse effects, and may provide a new option for hair regeneration therapy. To support the efficacy of growth factors and microneedling for AA treatment, additional large-scale studies of patients with AA are needed.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"33 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacopo Tartaglia, Stefano Piaserico, Luigi Naldi, Andrea Sechi
{"title":"Ablative CO2-Assisted Laser for Topical Drug Delivery in Nail Psoriasis: A Systematic Review","authors":"Jacopo Tartaglia, Stefano Piaserico, Luigi Naldi, Andrea Sechi","doi":"10.1159/000535022","DOIUrl":"https://doi.org/10.1159/000535022","url":null,"abstract":"Background: Nail psoriasis poses challenges for effective treatment, and topical drug delivery through the nail plate is limited. A novel approach to address this challenge involves the use of ablative fractional laser as a pretreatment strategy to enhance topical drug delivery for nail psoriasis. Summary: This systematic review, conducted in accordance with PRISMA guidelines, involved an extensive literature search across PubMed/MEDLINE, EMBASE, and the Cochrane Library up to July 2023. The primary focus was on exploring studies that investigated the application of ablative laser technology to augment drug delivery for nail psoriasis. Key Messages: (1) The review included seven randomized controlled trials, all examining the combination of fractional CO2 laser with topical treatments. These trials demonstrated varying degrees of improvement in nail psoriasis. (2) Patients undergoing laser treatment reported experiencing moderate levels of pain, effectively managed through the application of topical anesthesia. (3) Commonly observed side effects included erythema, swelling, and crusting, with the Koebner phenomenon being a rare occurrence. (4) Notably, patient satisfaction levels with the combined approach of laser and topical treatments were consistently high. In conclusion, the utilization of ablative CO2-assisted laser pretreatment, when used in conjunction with topical therapy, appears to be both effective and well-tolerated for the treatment of nail psoriasis. However, the establishment of optimal parameters and treatment intervals for fractional laser therapy remains an area for further research. Standardized studies are imperative to identify the most effective strategy for enhancing topical drug delivery in the context of nail psoriasis treatment.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" 3","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniela Baboun, Marita Yaghi, J. Keri, Brian W. Morrison
{"title":"Natural Treatment Options for Nail Disorders","authors":"Daniela Baboun, Marita Yaghi, J. Keri, Brian W. Morrison","doi":"10.1159/000534629","DOIUrl":"https://doi.org/10.1159/000534629","url":null,"abstract":"The growing demand for natural treatments has raised concerns among clinicians due to limited scientific evidence supporting their use. This review article addresses the issue by assisting dermatologists and general practitioners in recommending natural treatments for the following common nail disorders: nail brittleness, onychomycosis, periungual verrucae, paronychia, chloronychia, nail psoriasis, nail lichen planus, onychocryptosis, onycholysis, and congenital malalignment of the great toenail. One limitation is the scarcity of existing reviews on natural treatment options for nail disorders in the literature. Through a comprehensive review of existing literature, this article consolidates the available evidence on natural treatment options for these conditions. Although some natural treatments for nail disorders are supported by scientific evidence, the indiscriminate use of such remedies may lead to severe poisoning and health problems. Given the widespread and increasing use of natural treatments, clinicians play a pivotal role in educating patients about evidence-based remedies and debunking misleading claims. By doing so, clinicians can enhance patient safety and improve treatment outcomes. It is essential for healthcare professionals to be well-informed and equipped with the knowledge to differentiate between effective natural treatments and unverified claims, ensuring that patients receive appropriate care.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"115 18","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Werner Druck, Basel Medien AG, Dimitrios Rigopoulos – National, Dr Manuel Gea Gonzalez, Mexico City, Mexico, James Q. Del Rosso, Aditya K. Gupta, M. Hordinsky, Bryan C. Markinson, Andrew G. Messenger, J. Shapiro, R. Godse, M. P. P. Dany, S. Tamazian, PA Pittsburgh, J. Wan, M. Baltimore, M. Jen, A. I. P. P. Rubin, Espinoza-González, E. M. N.A. Carmona Hernandez, N. Okwundu, WA Kennewick, C. Ogbonna, A. McMichael, P. Kakizaki, L. A. Contin, M. Barletta, São Paulo, C. Machado, N. E. Trupiano, K. Z. Young, T. M. Benitez, J. Mervak, Ann Arbor, Cortez de Almeida, R. F. Melo, R. Janeiro, L. Drake, Ma Boston, J. M. I. Han, S. Boston, FL MAMiami, A. Mostaghimi, K. Huang, Guimerá Martin-Neda, La Laguna, A. K. Leroy, R. F. Cortez de Almeida, D. L. Obadia, Rio, A. Nwosu, M. Miteva, N. Kluger, P. R. Lindsø Andersen, Køge
{"title":"Contents 2023, Vol. 9","authors":"Werner Druck, Basel Medien AG, Dimitrios Rigopoulos – National, Dr Manuel Gea Gonzalez, Mexico City, Mexico, James Q. Del Rosso, Aditya K. Gupta, M. Hordinsky, Bryan C. Markinson, Andrew G. Messenger, J. Shapiro, R. Godse, M. P. P. Dany, S. Tamazian, PA Pittsburgh, J. Wan, M. Baltimore, M. Jen, A. I. P. P. Rubin, Espinoza-González, E. M. N.A. Carmona Hernandez, N. Okwundu, WA Kennewick, C. Ogbonna, A. McMichael, P. Kakizaki, L. A. Contin, M. Barletta, São Paulo, C. Machado, N. E. Trupiano, K. Z. Young, T. M. Benitez, J. Mervak, Ann Arbor, Cortez de Almeida, R. F. Melo, R. Janeiro, L. Drake, Ma Boston, J. M. I. Han, S. Boston, FL MAMiami, A. Mostaghimi, K. Huang, Guimerá Martin-Neda, La Laguna, A. K. Leroy, R. F. Cortez de Almeida, D. L. Obadia, Rio, A. Nwosu, M. Miteva, N. Kluger, P. R. Lindsø Andersen, Køge","doi":"10.1159/000535260","DOIUrl":"https://doi.org/10.1159/000535260","url":null,"abstract":"","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" 17","pages":"479 - 486"},"PeriodicalIF":1.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Atluri, D. De, T. Shih, Caitlyn B. Dagenet, Rahul Masson, Khiem A Tran, Vivienne Ng, Jennifer L. Hsiao, Vivian Y Shi
{"title":"Perspectives of Emergency Medicine Physicians on Hidradenitis Suppurativa Care","authors":"S. Atluri, D. De, T. Shih, Caitlyn B. Dagenet, Rahul Masson, Khiem A Tran, Vivienne Ng, Jennifer L. Hsiao, Vivian Y Shi","doi":"10.1159/000535189","DOIUrl":"https://doi.org/10.1159/000535189","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic skin condition that often requires acute care during periods of flares, with many patients visiting the emergency department over 5 times before receiving a proper diagnosis. However, little is known about emergency medicine (EM) providers’ experiences and knowledge of HS management. Methods: In this study, an anonymous survey was distributed to EM providers to identify knowledge and practice gaps in HS care. Results: The results showed that most respondents lacked confidence in HS diagnosis and management, especially in knowing available treatment options and managing patients with moderate to severe HS. Attendings were more confident than non-attendings in diagnosing and managing HS, and providers who saw more HS patients per month were more confident in referring patients to appropriate specialists. Over 80% of respondents referred HS patients to dermatology, which is an important initial step in HS management. Conclusion: The study highlights the importance of educating EM providers in HS recognition, timely referral to dermatology, and initial management to improve quality of life among patients and mitigate disease progression.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"112 12","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138623066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Co-Occurrence of Pityriasis Amiantacea and Cutis Verticis Gyrata Secondary to Leukaemia Cutis of the Scalp","authors":"Ankur Lal, Sushant Agrawal, Vishal Gaurav","doi":"10.1159/000535081","DOIUrl":"https://doi.org/10.1159/000535081","url":null,"abstract":"Introduction: Pityriasis amiantacea (PA) is a rare presentation characterized by the presence of extensive adherent scaling that tightly encircles and affixes tufts of hairs secondary to inflammatory or infectious dermatoses. However, the occurrence of PA as a consequence of leukaemia cutis has not been previously reported. Case Report: A 32-year-old man with B-cell acute lymphoblastic leukaemia (B-ALL) presented with severe scalp scaling and hair loss for 2 months. Examination revealed extensive, tightly adherent scales encircling and binding down hairs, along with haemorrhagic crusts. Skin examination showed nontender, partially blanchable papules forming ill-defined plaques, giving a cobblestone appearance. Trichoscopy revealed white crusts, tufting, and micro-haemorrhages. Scalp biopsy confirmed precursor B-ALL infiltration. He was diagnosed with PA with secondary cutis verticis gyrata due to leukaemia cutis and referred to a haemato-oncologist for further management. Discussion: Leukaemia cutis is a rare condition where leukaemia cells infiltrate the skin, often associated with acute myeloid leukaemia and ALL. It can lead to secondary verticis gyrata. The co-occurrence of PA and cutis verticis gyrata is rare and previously unreported, highlighting the need for increased awareness among clinicians.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"176 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139226075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamins for the Management of Nail Disease: A Literature Review","authors":"Kaya L. Curtis, Shari R. Lipner","doi":"10.1159/000534972","DOIUrl":"https://doi.org/10.1159/000534972","url":null,"abstract":"Background: Vitamins have gained popularity among physicians and patients for purported benefits to hair, skin, and nail health. Safe and efficacious therapies for nail disorders, many of which are chronic conditions, are needed. Summary: We conducted a literature review of studies assessing the efficacy of oral, topical, and intralesional vitamin/vitamin derivatives for the treatment of nail disorders, including yellow nail syndrome, brittle nail syndrome, onychomycosis, habit-tic nail deformity, periungual/subungual verruca, and nail psoriasis. Forty-nine articles were reviewed. There is good evidence to support the use of topical tazarotene and vitamin D analogs for nail psoriasis treatment. We found overall limited evidence for treatment of other nail disorders with vitamin/vitamin derivatives, and further research is needed to support their use. Key Messages: Besides topical tazarotene and vitamin D analogs for nail psoriasis treatment, there is limited evidence for treatment of nail disorders with topical, oral, and intralesional vitamin/vitamin derivatives.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"128 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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