Skin Appendage Disorders最新文献_第2页

Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients. 斑秃患者肠道游离脂肪酸结合蛋白4的测定。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-03 DOI: 10.1159/000541111

A E Soliman, Olfat Shaker, Samar M El-Tahlawi, Ghada Abdaltwab Mahgoub, Sara M Yaseen

{"title":"Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients.","authors":"A E Soliman, Olfat Shaker, Samar M El-Tahlawi, Ghada Abdaltwab Mahgoub, Sara M Yaseen","doi":"10.1159/000541111","DOIUrl":"10.1159/000541111","url":null,"abstract":"Introduction: Alopecia areata (AA) is an immune-mediated disease characterized by non-scaring hair loss. High levels of FABP4 have been implicated in different inflammatory diseases. We aim to assess and correlate the level of FABP4 in AA patients and compare with healthy controls.Methods: Eighty-Eight subjects enrolled subdivided equally into AA and healthy controls. AA patients were classified according to the severity and pattern of the disease. The concentration level of FABP4 in serum was assessed and compared to healthy controls using ELISA.Results: The level of FABP4 tends to increase in AA patients than controls with a significant difference (p = 0.0001).There were no statistically significant differences between FABP4 and gender, history, family history, related diseases, or prior treatments. There is a high significant difference between patients with relapse and progressive patients with p = 0.037. Also patients with positive effects in other body sites have higher FABP4 levels than patients without infection in other sites with p = 0.05. The level of FABP4 tends to increase with the severity of the patients. Findings show that there are positive correlations between FABP4 and (disease duration; number of attacks; SALT Score) with r = 0.45, p = 0.0021; r = 0.41, p = 0.007, and r = 0.88, p < 0.0001, respectively.Conclusion: Elevation of FABP4 in serum may correlate with disease severity and could play a vital role in the diagnosis of AA.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"112-118"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant Allergic Contact Dermatitis and Frontal Fibrosing Alopecia: A Potential Trigger for Relapse or Onset? 伴发过敏性接触性皮炎和额部纤维性脱发：复发或发病的潜在诱因？

IF 1.4

Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-24 DOI: 10.1159/000541604

Andrea Sechi, Angelo Valerio Marzano, Anna Belloni-Fortina, Anna Zambello

{"title":"Concomitant Allergic Contact Dermatitis and Frontal Fibrosing Alopecia: A Potential Trigger for Relapse or Onset?","authors":"Andrea Sechi, Angelo Valerio Marzano, Anna Belloni-Fortina, Anna Zambello","doi":"10.1159/000541604","DOIUrl":"10.1159/000541604","url":null,"abstract":"Introduction: Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia predominantly affecting postmenopausal women, with histopathological similarities to lichen planopilaris but distinct clinical features. The global rise in FFA cases over the past 15 years points to potential environmental factors.Case presentation: This study presents 2 FFA cases: one experiencing a flare-up and another with disease onset, both associated with allergic contact dermatitis. Case 1 involved a 58-year-old female with a flare-up linked to a nickel allergy, while case 2 described a 60-year-old female with new-onset FFA following exposure to hair dye allergens.Discussion: Environmental particles, such as titanium dioxide found on hair shafts of FFA patients, are hypothesized to contribute to FFA through photocatalytic activity causing tissue damage and inflammation. Studies indicate a higher use of facial moisturizers and sunscreens among FFA patients, with frequent positive patch test reactions to allergens in personal care products. These allergens may disrupt hair follicle immune privilege, leading to inflammation, fibrosis, and follicular destruction. Understanding the role of environmental factors in FFA pathogenesis may improve management strategies, emphasizing allergen avoidance and targeted treatments.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"198-201"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermoscopic Evaluation of Nail Changes in Patients with End-Stage Renal Disease on Regular Hemodialysis. 皮肤镜下对定期血液透析的终末期肾病患者指甲变化的评价。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-09-09 DOI: 10.1159/000539924

Sara A Galal, Hend G Kotb, Radwa O M Kamel, Hala M Elsadek, Hala S A Hafiz, Eman M Nassef, Sammar A Kasim, Samah M Akab, Ahmed S Abdel Sattar, Laila A Ahmed

{"title":"Dermoscopic Evaluation of Nail Changes in Patients with End-Stage Renal Disease on Regular Hemodialysis.","authors":"Sara A Galal, Hend G Kotb, Radwa O M Kamel, Hala M Elsadek, Hala S A Hafiz, Eman M Nassef, Sammar A Kasim, Samah M Akab, Ahmed S Abdel Sattar, Laila A Ahmed","doi":"10.1159/000539924","DOIUrl":"10.1159/000539924","url":null,"abstract":"Introduction: Chronic renal failure can impact various body systems, including the skin and its appendages. Patients with uremic conditions have been observed to experience a variety of nail changes. This study was conducted to evaluate the presence and type of fingernail changes in patients with end-stage renal failure (ESRF) on regular hemodialysis (HD) by nail dermoscopy.Methods: A total of 100 patients with ESRF on regular HD three times a week. Nails were examined by dermoscopy for the presence of subtle nail changes.Results: Nail changes were found in 91% of patients, while 9% did not have nail changes. The most common dermoscopic findings were as follows; scales in lateral nail fold in 91% of the patients, dry cuticle in 84%, onychoschizia in 72%, and longitudinal striation in 69%. There was no significant relation between nail changes and sex, duration of HD, and albumin level.Conclusion: Patients with end-stage renal disease on HD are more likely to experience nail disorders. Scales in LNF, dry cuticle, onychoschizia, longitudinal striation, terry's nails, and half-and-half nails were the most common nail changes in HD patients.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"103-111"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease - an All of Us Study. 甲沟炎：从皮肤科角度看潜在的全身性疾病--我们所有人的研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-05 DOI: 10.1159/000542382

Noelle Desir, Shari R Lipner

{"title":"Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease - an All of Us Study.","authors":"Noelle Desir, Shari R Lipner","doi":"10.1159/000542382","DOIUrl":"10.1159/000542382","url":null,"abstract":"Introduction: Nail clubbing is defined as distal phalanx thickening resulting in a bulbous appearance of the digit. We aimed to describe non-pulmonary medical conditions associated with nail clubbing using a cross-sectional approach.Methods: We conducted a cross-sectional analysis of the All of Us Research Program, identifying nail clubbing patients by ICD-10-CM and/or SNOMED code. Nail clubbing patients with pulmonary disease (cases) were compared to nail clubbing patients without pulmonary disease (controls). Fisher's exact test/Pearson's χ2 test analyzed categorical variables. Independent two-sample t tests analyzed continuous variables. Odds ratios (ORs) were analyzed with multivariate logistic regression adjusted for sociodemographic characteristics.Results: In total, 85 participants had nail clubbing, of which 63.53% had a pulmonary disease versus 36.47% of controls. Overall, across both cases and controls, 22% of patients had chronic liver disease, 17% hypothyroidism, 8% HIV infection, and 5% Graves' disease/hyperthyroidism. Male versus female patients with nail clubbing had decreased odds of having concurrent respiratory disease diagnosis (OR, 0.37; 95% CI, 0.14-0.92, p = 0.03).Conclusion: Greater than one-third of patients had nail clubbing associated with a non-pulmonary systemic disease, and a significant proportion were male. Consideration of a broad differential of pathologies associated with nail clubbing is needed to initiate workup and make appropriate screening referrals.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"186-191"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail Supplements: When, How, and Why? 指甲补充剂：何时，如何，为什么？

IF 1.4

Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-09-26 DOI: 10.1159/000541048

Ines Zaraa, Bertrand Richert

引用次数: 0

The First Colombian Patient with CDH3-Related Hypotrichosis with Juvenile Macular Dystrophy. 哥伦比亚首位cdh3相关性毛少症伴幼年黄斑营养不良患者

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-28 DOI: 10.1159/000545293

Luis Eduardo Prieto, Diana Marcela Vasquez-Forero, Harry Pachajoa

引用次数: 0

Secondary Intention Healing after Functional Surgery for Melanoma of the Nail Apparatus: Functional, Cosmetic, and Patient Satisfaction Results. 甲器黑色素瘤功能性手术后的二次意向愈合：功能、美容和患者满意度结果。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-28 DOI: 10.1159/000545468

Jonathan Stevens, Martín Céspede-Núñez

{"title":"Secondary Intention Healing after Functional Surgery for Melanoma of the Nail Apparatus: Functional, Cosmetic, and Patient Satisfaction Results.","authors":"Jonathan Stevens, Martín Céspede-Núñez","doi":"10.1159/000545468","DOIUrl":"https://doi.org/10.1159/000545468","url":null,"abstract":"Introduction: Functional surgery is the preferred approach for nail melanoma in situ (NMIS) and minimally invasive nail melanoma (MINM, Breslow ≤0.5 mm). Secondary intention healing (SIH) offers an alternative to traditional skin grafting, with favorable cosmetic, functional, and satisfaction outcomes and minimal complications.Methods: Six patients (mean age 54.8 years; 4 SMIS, 2 MISSM) underwent functional surgery with SIH. Healing times (granulation [T1] and re-epithelialization [T2]), complications, and outcomes were assessed at 12 weeks using QUICK-DASH, VBSAS, VAS, satisfaction scores, and DLQI.Results: Mean T1 and T2 were 2.83 and 8.45 weeks, respectively. One patient experienced intense postoperative pain; another had a late nail spike. No hyperpigmentation or recurrences were observed. Outcomes: QUICK-DASH 18.92%; VBSAS 2.8 (12 weeks) and 0.25 (24 weeks); VAS 2; DLQI 2; and satisfaction 9.8/10 (10/10 after amputation discussion).Conclusions: SIH provides an effective alternative to grafting, allowing acceptable healing times, flexibility for margin extension or amputation, and excellent cosmetic, functional, and satisfaction outcomes with minimal complications.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Amputative Digit Preservation Surgery versus Amputation in Nail Unit Melanoma: A Retrospective Study in Mexico and Brazil. 指甲单位黑色素瘤的非截肢手指保留手术与截肢：墨西哥和巴西的回顾性研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000544995

Jorge Ocampo-Garza, Adriana G Peña-Romero, Eduardo Bertolli, Mayra A Reyes Soto, Nilton Gioia Di Chiacchio, Francisco A Belfort, Veronica Fonte-Avalos, Nilton Di Chiacchio, Judith Domínguez-Cherit

{"title":"Non-Amputative Digit Preservation Surgery versus Amputation in Nail Unit Melanoma: A Retrospective Study in Mexico and Brazil.","authors":"Jorge Ocampo-Garza, Adriana G Peña-Romero, Eduardo Bertolli, Mayra A Reyes Soto, Nilton Gioia Di Chiacchio, Francisco A Belfort, Veronica Fonte-Avalos, Nilton Di Chiacchio, Judith Domínguez-Cherit","doi":"10.1159/000544995","DOIUrl":"https://doi.org/10.1159/000544995","url":null,"abstract":"Introduction: Nail unit melanoma (NUM) is a rare but aggressive malignancy with historically poor outcomes. Currently, there are no treatment guidelines for NUM.Methods: A retrospective analysis was conducted on patients diagnosed with NUM in Mexico and Brazil. Clinical and histopathological data were reviewed, and outcomes were compared between those who underwent amputation versus digit preservation surgery. Survival rates, recurrence, and functional status were assessed.Results: A total of 75 patients from Mexico (51.9%) and Brazil (48.1%) were evaluated. Clinical and pathological characteristics were similar between both groups. Functional surgery was performed in 40 patients (49.4%), including six with invasive melanomas. The median follow-up was 50.3 months (95% CI: 29.4-71.3, SE: 10.7). Among the 7 patients with invasive melanomas who underwent functional surgery, one experienced a recurrence, and one died from a cerebrovascular accident. The remaining 5 patients are alive and disease-free, with follow-up periods ranging from 1 to 27 months.Conclusions: Non-amputative surgery may be a safe alternative for thin NUMs, reducing amputation-related morbidity. Long-term follow-up and larger studies are needed to confirm guidelines.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatological Comorbidities Accompanying Rosacea and Their Relationship with Clinical and Demographic Features, Quality of Life, and Systemic Comorbidities: A Retrospective, Case-Controlled, Multicenter Survey. 伴随酒渣鼻的皮肤病合并症及其与临床和人口学特征、生活质量和全身合并症的关系：一项回顾性、病例对照、多中心调查。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000545295

Berna Aksoy, Elif Yıldırım, Ezgi Aktaş, Mualla Polat, Kıymet Handan Kelekci, Mustafa Tosun, Aysun Sikar Aktürk, Ilkin Zindancı, Seniz Duygulu, Emine Çölgeçen, Zehra Asiran Serdar, Ömer Kutlu, Neslihan Fişek İzci, Ayşe Serap Karadağ

{"title":"Dermatological Comorbidities Accompanying Rosacea and Their Relationship with Clinical and Demographic Features, Quality of Life, and Systemic Comorbidities: A Retrospective, Case-Controlled, Multicenter Survey.","authors":"Berna Aksoy, Elif Yıldırım, Ezgi Aktaş, Mualla Polat, Kıymet Handan Kelekci, Mustafa Tosun, Aysun Sikar Aktürk, Ilkin Zindancı, Seniz Duygulu, Emine Çölgeçen, Zehra Asiran Serdar, Ömer Kutlu, Neslihan Fişek İzci, Ayşe Serap Karadağ","doi":"10.1159/000545295","DOIUrl":"https://doi.org/10.1159/000545295","url":null,"abstract":"Introduction: As rosacea patients are generally light-skinned and photosensitized some sun-related skin findings are likely to be observed. This study aimed to determine which dermatological comorbidities accompany rosacea and evaluate their relationship with clinical, demographic, quality-of-life, and systemic comorbidities.Methods: This case-control multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Patient demographics, clinical findings, lifestyle data, medical history, and dermatological comorbidities were collected using a structured physician-administered questionnaire. All patients completed the Dermatology Life Quality Index.Results: The study included 922 rosacea patients and 799 controls without rosacea. Rosacea patients had higher dermatological comorbidities than controls. The prevalence of skin comorbidities increased as patient age and duration of rosacea increased. Additionally, these skin comorbidities negatively affected quality of life. Some dermatological comorbidities, especially civatte poikiloderma, had strongest predictive risk (odds ratio ⫺3) of significant systemic comorbidities.Conclusion: Based on the present findings, clinicians should also assess rosacea patients for cutaneous dermatological comorbidities. Presence of skin comorbidities increased as patient age and duration of rosacea increased and might be predictive of systemic comorbidities.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scarring Alopecia and Risk of Skin Cancer: A Literature Review. 瘢痕性脱发与皮肤癌风险：文献综述。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000545345

Juwon Lee, Ludovica de Gregorio, Antonella Tosti

{"title":"Scarring Alopecia and Risk of Skin Cancer: A Literature Review.","authors":"Juwon Lee, Ludovica de Gregorio, Antonella Tosti","doi":"10.1159/000545345","DOIUrl":"https://doi.org/10.1159/000545345","url":null,"abstract":"Background: Primary scarring alopecia is characterized by irreversible hair follicle destruction and chronic inflammation, which may create a microenvironment conducive to skin cancer development. Non-melanoma skin cancers (NMSCs), such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), are influenced by factors like UV exposure and prolonged inflammation. The link between primary scarring alopecia and increased scalp skin cancer risk remains unclear.Summary: This review analyzed thirteen studies reporting NMSC in primary scarring alopecia subtypes, including lichen planopilaris, discoid lupus erythematosus, folliculitis decalvans, and erosive pustular dermatosis of the scalp. Chronic inflammation, UV exposure, and immunosuppressive therapies were identified as potential contributors to malignancy.Key messages: Primary scarring alopecia may increase susceptibility to SCC and BCC, particularly in areas of prolonged inflammation or immunosuppression. Clinicians should emphasize sun protection, routine follow-up, and patient education to minimize risk and improve outcomes. Further research is needed to clarify these associations.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0