Skin Appendage Disorders最新文献_第2页

An Unusual Compulsive Behavior Related to Scalp Psoriasis and Hair Follicle Anxiety in Young Men. 一种与年轻男性头皮牛皮癣和毛囊焦虑相关的异常强迫行为。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-14 DOI: 10.1159/000547907

Ramon Grimalt

{"title":"An Unusual Compulsive Behavior Related to Scalp Psoriasis and Hair Follicle Anxiety in Young Men.","authors":"Ramon Grimalt","doi":"10.1159/000547907","DOIUrl":"10.1159/000547907","url":null,"abstract":"Introduction: Patients suffering from androgenetic alopecia may experience obsessive behaviors on observing their own scalp.Case presentation: This article describes a series of three cases of young men presenting with an unusual, seemingly compulsive behavior related to mild scalp psoriasis and a family history of androgenetic alopecia. Contrary to the typical goal of psoriasis treatment, these patients exhibit an intense fixation on scalp scales containing embedded hairs. They actively avoid dislodging these scales during routine hygiene or therapeutic efforts, fearing that their removal might accelerate hair loss. The cases involve young men (aged 24, 19, and 22) with significant anxiety about hair loss, which manifests as a meticulous and repetitive manipulation of their scalps to preserve these specific scales.Conclusion: This behavior may fall within the spectrum of body-focused repetitive behaviors. This observation underscores the importance for dermatologists to thoroughly question patients about underlying anxieties and specific scalp manipulation behaviors, especially in young men with a familial history of alopecia, to facilitate more effective clinical management.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Disparities in Healthcare Resource Utilization among Patients with Hidradenitis Suppurativa: An All of Us Database Analysis. 化脓性汗腺炎患者医疗资源利用的种族差异：一个我们所有人的数据库分析。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-11 DOI: 10.1159/000547793

Lauren Fleshner, Mehmet Fatih Atak, Katie Roster, Banu Farabi

{"title":"Racial Disparities in Healthcare Resource Utilization among Patients with Hidradenitis Suppurativa: An All of Us Database Analysis.","authors":"Lauren Fleshner, Mehmet Fatih Atak, Katie Roster, Banu Farabi","doi":"10.1159/000547793","DOIUrl":"10.1159/000547793","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) disproportionately affects historically underrepresented populations, with social determinants of health (SDoH) contributing to disparities in access to care, specialty services, and medication access. This study aimed to evaluate healthcare utilization in HS, stratified by race, to better understand the role of SDoH.Methods: A cross-sectional analysis using the All of Us database was conducted using variables including surgical procedures, healthcare utilization, biologic use, and pertinent comorbidities (diabetes, obesity, smoking, sepsis). Survey data assessed socioeconomic factors and healthcare access. Chi-square tests were used (p < 0.005); analyses were performed in RStudio 4.1.2.Results: Among 2,265 patients with HS (40.26% African American, 77.48% female), African American patients had higher rates of emergency department visits, diabetes, complex surgeries, and inability to afford medications (all p < 0.01). White patients had more outpatient visits and delays in care due to anxiety (p < 0.0005 and p < 0.026, respectively).Conclusions: Racial disparities in HS healthcare utilization reflect the impact of SDoH, with African American patients experiencing greater disease burden. Early identification of high-risk patients and targeted interventions are essential to promote equitable care.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal Remedies for Hair Loss: A Review of Efficacy and Safety. 治疗脱发的草药：疗效和安全性综述。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-20 DOI: 10.1159/000542876

Azhar Ahmed, Azhar M Alali, Ebtesam Abdullah, Mohammed N Alharbi, Hamza M Alayoubi

{"title":"Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.","authors":"Azhar Ahmed, Azhar M Alali, Ebtesam Abdullah, Mohammed N Alharbi, Hamza M Alayoubi","doi":"10.1159/000542876","DOIUrl":"https://doi.org/10.1159/000542876","url":null,"abstract":"Background: Hair loss (HL) is a prevalent condition worldwide; it can affect both males and females of different age groups. Despite the availability of many conventional treatment options, these might be linked to causing different side effects, leading to a growing interest in natural and herbal remedies (HRs). This review aims to investigate the efficacy and safety of various HRs for HL and examine the current scientific evidence behind them.Summary: A literature search used several studies to identify relevant studies published up to March 2024. The search terms included HL, alopecia, HRs, and names of specific herbs such as rosemary, saw palmetto, onion juice, Korean red ginseng, pumpkin seed oil, azelaic acid, olive oil, coconut oil, henna, honey, rice bran extract, Ashwagandha, and amla. Studies have suggested potential benefits in promoting hair growth and treating various forms of HL. These remedies were found to be effective in different conditions, including androgenetic alopecia, telogen effluvium, and alopecia areata, through various mechanisms of action, including 5α-reductase inhibition, increased microcapillary blood flow, antioxidant effects, and modulation of the hair growth signaling pathways.Key messages: Natural and HRs show promise in treating HL. However, many of these studies have limitations such as lack of long-term follow-up, small sample sizes, and short treatment durations. Due to this variation in the quality of evidence, further well-designed randomized trials with larger sample sizes are required to confirm the efficacy of these HRs.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"360-371"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool. 应用疾病症状学指导中心性离心性瘢痕性脱发患者的治疗：C-CAT评分工具的介绍。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-02-20 DOI: 10.1159/000544777

Aasheen Qadri, Elizabeth Will, Crystal Aguh

{"title":"Using Disease Symptomatology to Guide Treatment in Patients with Central Centrifugal Cicatricial Alopecia: Introduction of C-CAT Scoring Tool.","authors":"Aasheen Qadri, Elizabeth Will, Crystal Aguh","doi":"10.1159/000544777","DOIUrl":"https://doi.org/10.1159/000544777","url":null,"abstract":"Introduction: Central centrifugal cicatricial alopecia (CCCA) is a progressive scarring alopecia. No disease activity scale exists, making assessment of therapeutic intervention difficult. This study introduces the CCCA Clinical Assessment Tool (C-CAT), a novel scale that quantifies symptom severity to facilitate tailored treatment and track disease progression.Methods: A retrospective review of patients with CCCA was assessed on degree of pruritus, erythema, pain, disease progression, and scalp resistance, each scored from 0 to 2, over the course of a minimum of 6 months of therapy.Results: Eighty-two patients were included. The average initial C-CAT score was 3.4, consistent with mild to moderate disease activity. After 6 months of treatment, 88% of patients had improvement in score, with 48% of all patients achieving remission. Intralesional kenalog injections and topical clobetasol were the most commonly used therapies. Patients required an average of 3.6 different treatments to achieve therapeutic response.Conclusion: The C-CAT provides a structured, quantitative method to assess CCCA severity, which facilitates tracking of disease improvement for the majority of patients with targeted therapy. While the subjective nature of some C-CAT components may lead to inter-rater variability, this tool promotes personalized, symptom-based treatment and supports clinicians and patients in understanding this complex condition.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"309-315"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intralesional Nail Infiltration. 指甲局部浸润。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-17 DOI: 10.1159/000543538

Laura Bertanha, Leandro Fonseca Noriega, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio

引用次数: 0

A Case-Control Study of Trichotillomania Patients Using a National Database. 使用国家数据库对拔毛癖患者进行病例对照研究。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-27 DOI: 10.1159/000543503

Aarushi K Parikh, Noah Musolff, Madeline Tchack, Babar Rao

{"title":"A Case-Control Study of Trichotillomania Patients Using a National Database.","authors":"Aarushi K Parikh, Noah Musolff, Madeline Tchack, Babar Rao","doi":"10.1159/000543503","DOIUrl":"https://doi.org/10.1159/000543503","url":null,"abstract":"Introduction: Trichotillomania (TTM) is a body-focused repetitive disorder linked to psychiatric comorbidities. Comprehensive studies mapping its associations with a range of conditions remain limited. This study examines TTMs associations with psychiatric, neurodevelopmental, substance-related, reproductive, and social factors using a national database.Methods: We performed a case-control study using the All of Us Research Program database. TTM cases (n = 40) were matched to controls (n = 400) based on age, sex, and ethnicity. Multivariate logistic regression was used to examine associations with comorbidities and lifestyle factors, controlling for demographic variables.Results: TTM was significantly associated with obsessive-compulsive disorder (odds ratio [OR] 18.3), borderline personality disorder (OR 15), anxiety disorders (OR 10.2), alcohol abuse (OR 6.13), depression (OR 5.89), and vitamin D deficiency (OR 4.2) (all p < 0.01). Other significant associations included fatigue, social anxiety, post-traumatic stress disorder, ADHD, and difficulty running errands alone.Conclusion: Our findings highlight the strong association between TTM and a wide range of psychiatric and behavioral conditions, emphasizing the need for integrated treatment strategies addressing both psychiatric and physical aspects.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"379-384"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Practices of Subspecialty Nail Clinics: Results of a Survey of the Members of the Council for Nail Disorders. 亚专科指甲诊所的现行做法：指甲疾病理事会成员调查的结果。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-13 DOI: 10.1159/000543535

Safinaz Soliman, Phoebe Rich, Molly A Hinshaw

{"title":"Current Practices of Subspecialty Nail Clinics: Results of a Survey of the Members of the Council for Nail Disorders.","authors":"Safinaz Soliman, Phoebe Rich, Molly A Hinshaw","doi":"10.1159/000543535","DOIUrl":"https://doi.org/10.1159/000543535","url":null,"abstract":"Introduction: Knowledge of the structure and function of existing nail clinics remains limited. Sharing this knowledge from nail experts who run these clinics can readily support newly trained nail clinicians in setting up their nail clinics.Method: We surveyed members of the Council for Nail Disorders (CND) to learn about the structure and practices of their nail clinics. Of the practicing CND members in any membership class, we analyzed responses from those who have nail clinics.Results: Of the 79 practicing CND members, 38 responded (48.1% response rate), of whom 25 (65.8%) had a nail clinic. Analysis of these 25 responses revealed that 52% of nail clinics were relatively new (operating <5 years). The majority (72%) were in academic settings. Medical trainees were being taught in 64% of clinics. Nail clinics were directed by either one (64%) or multiple clinicians. All experts reported using clinical photographs in their routine care for nail patients, and 96% used dermoscopy. Additionally, 96% performed punch and tangential shave biopsies, and 88% performed matrixectomy. Access to a pathologist(s) with nail expertise was available in 84% of clinics.Conclusion: Our findings characterize the current practices of nail clinics directed by CND members, serving as a guide for clinicians looking to establish their own.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"372-378"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palmoplantar Pustulosis during Pregnancy Was Successfully Treated with Tofacitinib: A Case Report. 托法替尼成功治疗妊娠期掌足底脓疱病1例。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-02-26 DOI: 10.1159/000544921

Bingyan Dong, Fanzhang Meng, Jinian Wei, Zhimin Lin, Weizhong Li, Chen Li, Xiujuan Hou

{"title":"Palmoplantar Pustulosis during Pregnancy Was Successfully Treated with Tofacitinib: A Case Report.","authors":"Bingyan Dong, Fanzhang Meng, Jinian Wei, Zhimin Lin, Weizhong Li, Chen Li, Xiujuan Hou","doi":"10.1159/000544921","DOIUrl":"https://doi.org/10.1159/000544921","url":null,"abstract":"Introduction: Palmoplantar pustulosis (PPP) is a common chronic recurrent skin disease characterized by sterile pustules on the palms and soles of the feet. Most patients with PPP have a rash that improves during pregnancy due to the influence of estrogen and progesterone, but relatively few have an exacerbation of the rash during pregnancy.Case introduction: Here, we show a female patient diagnosed with PPP, whose rash worsened during pregnancy and gestation. Her lesions were painful and cracked, interfering with normal walking and sleep, and was poorly treated with hormonal ointments and ultraviolet light. She gave birth to a healthy baby boy at 39 weeks plus 4 days of gestation after regular monitoring and stopped breastfeeding at 6 months of age and then presented to the outpatient clinic. For sterile pustules, we choose tofacitinib at a dosage of 5 mg b.i.d. Three months after taking the medication, the pustules on her hands and feet had mostly disappeared. Follow-up showed that the condition remained stable without recurrence.Conclusion: Aggravation of PPP during pregnancy is relatively rare. Tofacitinib, as an oral JAK inhibitor, is effective in the treatment of PPP exacerbated during pregnancy, but the risk to mother and child is unknown, and the relationship between tofacitinib and pregnancy outcome should be further investigated.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"335-338"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nail Involvement in Pemphigus: A Clinical and Dermoscopic Prospective Study. 天疱疮累及指甲：一项临床和皮肤镜前瞻性研究。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-01-10 DOI: 10.1159/000543450

Anissa Zaouak, Amal Chamli, Oumayma Magdoud, Reka Frioui, Houda Hammami, Samy Fenniche

{"title":"Nail Involvement in Pemphigus: A Clinical and Dermoscopic Prospective Study.","authors":"Anissa Zaouak, Amal Chamli, Oumayma Magdoud, Reka Frioui, Houda Hammami, Samy Fenniche","doi":"10.1159/000543450","DOIUrl":"https://doi.org/10.1159/000543450","url":null,"abstract":"Introduction: Nail involvement in pemphigus (NIP) was considered as a rare finding and a predictor factor of the severity of pemphigus. The diagnosis of NIP can be challenging, as it can be mistaken for other nail disorders. The aim of our study was to provide an overview of NIP, with a focus on the dermoscopy role to detect these nail changes.Methods: A monocentric prospective study was performed from January 2018 to December 2022, investigating clinically and with a dermoscope NIP.Results: Our study included 32 patients, among them 6 patients with NIP. The mean age was 53 years. The average duration of the disease at presentation was 4.5 months. Five patients (83%) had pemphigus vulgaris and 1 patient was diagnosed with paraneoplastic pemphigus. In 5 cases (83%), the disease was severe, with 4 cases having frequent exacerbations (66.7%). The average number of nails involved was 9. In 3 cases, only the fingernails were involved. The nail lesions were concomitant to the mucocutaneous lesions in half our cases. Onycholysis and subungual hemorrhage were the most frequent dermoscopic findings (83%). Paronychia and dyschromia were seen in 4 patients. In 3 cases, cuticular loss and onychomadesis were seen.Conclusion: Dermoscopic features such as subungual hemorrhage, onycholysis, and paronychia can help distinguish pemphigus-related nail changes from other conditions.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"339-343"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management and Genetics of Alopecia Areata within the USA: A Cross-Sectional Study of All of Us. 美国斑秃的管理和遗传学：我们所有人的横断面研究。

IF 1.3

Skin Appendage Disorders Pub Date : 2025-08-01 Epub Date: 2025-03-11 DOI: 10.1159/000545194

Aditya K Gupta, Vasiliki Economopoulos

{"title":"Management and Genetics of Alopecia Areata within the USA: A Cross-Sectional Study of All of Us.","authors":"Aditya K Gupta, Vasiliki Economopoulos","doi":"10.1159/000545194","DOIUrl":"https://doi.org/10.1159/000545194","url":null,"abstract":"Introduction: Alopecia areata (AA) is a difficult to treat and appearance altering disorder affecting up to 2% of people during their lifetime. Understanding current management trends will help in improving patient outcomes. The aim of this study was to determine the impact of comorbid disorders and demographic factors on the management of AA and determine the influence of previously discovered genetic factors in different ethnic groups.Methods: We used the All of Us controlled dataset (version 7) and examined electronic health record and genomic data from 206,173 participants in a retrospective cross-sectional study conducted in outpatients in the USA.Results: We found that AA patients with comorbid atopic dermatitis, psoriasis, and vitiligo were more likely to have been prescribed topical corticosteroids. Patients that were not of European/Caucasian ancestry were less likely to be prescribed any type of corticosteroid. We also found that specific genetic variations (single nucleotide polymorphisms) that increased or decreased risk in European/Caucasian participants did not necessarily have the same effect in other ethnicities (Hispanics and blacks).Conclusion: This work has helped uncover the state of AA care within the USA and has identified access to healthcare inequities in different ethnic populations.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 4","pages":"344-354"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0