Skin Appendage Disorders最新文献_第3页

Gout Affecting the Nail Unit: Report of Two Cases and Literature Review 影响指甲的痛风：两个病例的报告和文献综述

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Skin Appendage Disorders Pub Date : 2023-11-21 DOI: 10.1159/000534668

Jeffery Z. Hu, N. Jellinek, Molly A. Hinshaw

引用次数: 0

Multiple-Digit Pigmented Bowen’s Disease Induced by Human Papillomavirus in an Immunocompetent Child 免疫功能正常儿童的人类乳头瘤病毒诱发的多位数色素性鲍温氏病

IF 1

Skin Appendage Disorders Pub Date : 2023-11-20 DOI: 10.1159/000534734

G. A. Guerrero-González, N. D. Di Chiacchio, Francisco Macedo Paschoa, N. D. Di Chiacchio

{"title":"Multiple-Digit Pigmented Bowen’s Disease Induced by Human Papillomavirus in an Immunocompetent Child","authors":"G. A. Guerrero-González, N. D. Di Chiacchio, Francisco Macedo Paschoa, N. D. Di Chiacchio","doi":"10.1159/000534734","DOIUrl":"https://doi.org/10.1159/000534734","url":null,"abstract":"Introduction: Bowen’s disease is a squamous cell carcinoma in situ, the most common malignancy of the nail unit. Presenting more frequently in the fingernails, common risk factors include ionizing radiation, oral exposure to arsenic or pesticides, dyskeratosis congenita, and quite commonly diverse subtypes of HPV. We report the first case of multiple periungual pigmented Bowen’s disease in a pediatric patient. Case Presentation: A healthy 13-year-old boy presented with a 9-month history of a pigmented erythematous patch on the proximal nail fold of his 3rd right finger without associated symptoms. A punch biopsy was taken, and the diagnosis of Bowen’s disease was made. The patient received photodynamic therapy and three cycles of imiquimod without response, and two new lesions appeared on the first and second right fingers. Surgical removal was performed on all lesions. A polymerase chain reaction detected an HPV type 16. Discussion/Conclusion: Multiple periungual Bowen’s disease is rare, with the most frequent risk factors being HPV infection and chronic immunosuppression. Less than 10% of the cases present as longitudinal melanonychia. To date, there are no previous reports of multiple pigmented periungual Bowen’s disease. HPV-induced Bowen’s disease is usually present in adults aged between 22 and 89 years as persistent verrucae. In this case, koilocytosis and the fact that all lesions appeared on the right hand are suggestive of HPV infection.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"56 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Delay in Hidradenitis Suppurativa: Still an Unsolved Problem 化脓性扁桃体炎的诊断延迟：仍未解决的问题

IF 1

Skin Appendage Disorders Pub Date : 2023-11-17 DOI: 10.1159/000534845

I. Aparício Martins, B. Figueira Vilela, Joana Cabete

{"title":"Diagnostic Delay in Hidradenitis Suppurativa: Still an Unsolved Problem","authors":"I. Aparício Martins, B. Figueira Vilela, Joana Cabete","doi":"10.1159/000534845","DOIUrl":"https://doi.org/10.1159/000534845","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a diagnostic delay of 7–10 years. A later diagnosis is associated with development of local sequelae and systemic comorbidities, as well as a reduced response to medical treatment. The aim of this study was to analyze the time required for HS diagnosis and investigate factors associated with diagnostic delay. Method: A retrospective observational study was conducted based on clinical records from HS patients followed at a tertiary hospital, with diagnosis between January 2006 and December 2022. Results: A total of 285 patients were included. The mean diagnostic delay was 10.1 years, and there was no difference in time to diagnosis during the considered period. A diagnostic delay of more than 5 years was significantly associated with an earlier onset of symptoms, location on breasts and thighs, follicular phenotype, and with cardiovascular and psychiatric comorbidities. Smoking and body mass index ≥25 kg/m2 were also associated with a longer diagnostic delay. A personal history of acne and a greater disease severity were associated with an earlier diagnosis. Conclusions: This study reveals the lack of improvement in the diagnostic delay in HS and highlights its association with atypical clinical manifestations and systemic comorbidities, scarcely reported in literature.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139265799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgenetic Alopecia in Children and Adolescents: From Trichoscopy to Therapy 儿童和青少年的雄激素性脱发：从三棱镜检查到治疗

IF 1

Skin Appendage Disorders Pub Date : 2023-11-16 DOI: 10.1159/000534844

Maria Rubi Losoya-Jaquez, Arturo Lopez Yañez-Blanco, Yonatan Armendariz-Barragan, Nidia Gabriela Aguilar-Figueroa, Lidia Rudnicka, L. E. Sánchez-Dueñas

{"title":"Androgenetic Alopecia in Children and Adolescents: From Trichoscopy to Therapy","authors":"Maria Rubi Losoya-Jaquez, Arturo Lopez Yañez-Blanco, Yonatan Armendariz-Barragan, Nidia Gabriela Aguilar-Figueroa, Lidia Rudnicka, L. E. Sánchez-Dueñas","doi":"10.1159/000534844","DOIUrl":"https://doi.org/10.1159/000534844","url":null,"abstract":"Introduction: Pediatric androgenetic alopecia is a product of hormonal and genetic factors. The diagnosis depends on recognizing the hair loss pattern in the context of a positive family history and a typical trichoscopy. Methods: A multicenter retrospective study assessing medical data from January 2008 to January 2023 of two reference centers – one public and one private in west Mexico. Patients under 18 years old were included. The clinical features, trichoscopic findings, associated conditions, and treatment received were documented and analyzed. Results: We found 145 patients, with a mean age of 16.08 ± 1.30 years, predominantly comprising males (72%). Trichoscopy was performed on 33 patients. The main trichoscopic findings were hair shaft thickness variability in 100% of the cases, vellus hair in 85%, and single-hair units in 79%. Vitamin D deficiency was found in 84% of the cases with laboratory determination, insulin resistance in 33%, and hyperandrogenemia in 12.5%. Topical minoxidil emerged as the main treatment modality in 24% of cases, demonstrating both efficacy and tolerability. Conclusion: Pediatric androgenetic alopecia could be more prevalent than commonly perceived, potentially explained by the lower level of suspicion among medical practitioners. Distinctive trichoscopic findings offer valuable guidance for therapeutic strategies and ongoing management.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triamcinolone Acetonide Injections in Nail Psoriasis: A Pragmatic Analysis 曲安奈德注射治疗甲型银屑病的临床分析

Skin Appendage Disorders Pub Date : 2023-11-14 DOI: 10.1159/000534699

Chander Grover, Geetali Kharghoria, Shikha Bansal

{"title":"Triamcinolone Acetonide Injections in Nail Psoriasis: A Pragmatic Analysis","authors":"Chander Grover, Geetali Kharghoria, Shikha Bansal","doi":"10.1159/000534699","DOIUrl":"https://doi.org/10.1159/000534699","url":null,"abstract":"Introduction: Treatment of nail psoriasis is challenging. Systemic therapies may be difficult to justify, while topical therapies may be sup-optimal. Triamcinolone acetonide (TA) injections are recommended as first-line therapy in cases with less than 3 nails involved; however, limited studies are available. This study was conducted to evaluate the reduction in NAPSI (Nail Psoriasis Severity Index) with TA injections in patients with isolated nail psoriasis. Methods: A retrospective case record analysis of efficacy and safety of TA (5 mg/mL) nail injections (4-weekly for fingernails, 8-weekly for toenails) was done in 10 patients. NAPSI was evaluated at each visit and treatment endpoint (75% reduction or 10 injections, whichever was earlier). Dropouts and adverse effects were recorded. Results: Among 10 patients (94 involved nails, 61 fingernails, and 33 toenails), 3 patients (30%) dropped out (2, 4, and 5 sessions, respectively), citing procedural pain. Three patients achieved NAPSI-75 (3, 6, and 7 sessions, respectively). Baseline mean NAPSI of 5.03 (4.63 fingernails and 5.78 toenails) dropped to 3.67 (3.13 fingernails and 4.42 toenails) by the 5th injection; and 2.35 (2.13 fingernails and 2.59 toenails) by the 10th injection. Adverse effects included pain (30%), subungual haematoma (1.7%), and proximal nail fold hypopigmentation with mild atrophy (1.1%). Conclusions: TA (5 mg/mL) injections are effective in nail psoriasis and associated with minimal adverse effects.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"14 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134955345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eczema-Like Psoriasiform Dermatitis due to Hair Straighteners: Trichoscopic Findings and Clinical Experience in Its Management 直发器引起的湿疹样银屑病样皮炎:毛发镜检查结果及其治疗的临床经验

Skin Appendage Disorders Pub Date : 2023-11-10 DOI: 10.1159/000534695

Yonatan Armendariz-Barragan, Daniel Jimenez-Zaragoza, Luis Enrique Sánchez-Dueñas

{"title":"Eczema-Like Psoriasiform Dermatitis due to Hair Straighteners: Trichoscopic Findings and Clinical Experience in Its Management","authors":"Yonatan Armendariz-Barragan, Daniel Jimenez-Zaragoza, Luis Enrique Sánchez-Dueñas","doi":"10.1159/000534695","DOIUrl":"https://doi.org/10.1159/000534695","url":null,"abstract":"Introduction: Eczema-like psoriasiform dermatitis has been described as a complication after Brazilian keratin treatment, with the presence of perifollicular scale resembling the outer skin of an onion bulb reported as a characteristic trichoscopic feature. To date, no treatment for this condition has been communicated. Methods: A retrospective study was conducted on patients diagnosed with eczema-like psoriasiform dermatitis. Clinical and trichoscopic images were analyzed, and the improvement in the scale and the vascular component of patients treated with oral isotretinoin was described. Results: A total of 132 patients were included. The most frequent trichoscopic findings were perifollicular scale, peripilar desquamation, and interfollicular scale. Most of the 7 patients treated with oral isotretinoin showed a partial improvement in the scale and the vascular component. Conclusion: The peripilar scale resembling the outer skin of an onion bulb could be used as a marker for this disease. We observed partial response to oral isotretinoin, probably due to the chronic character of this condition secondary to continuous release of formaldehyde, suboptimal doses, or a short treatment time.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"85 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipedematous Scalp Occurring in Two Female Siblings: Further Evidence for a Genetic Role 两个女性兄弟姐妹发生的头皮油肿:遗传作用的进一步证据

Skin Appendage Disorders Pub Date : 2023-11-10 DOI: 10.1159/000534698

Nada Khalil, James Carton, Carolina P. Fernandez, Neil P. Patel

{"title":"Lipedematous Scalp Occurring in Two Female Siblings: Further Evidence for a Genetic Role","authors":"Nada Khalil, James Carton, Carolina P. Fernandez, Neil P. Patel","doi":"10.1159/000534698","DOIUrl":"https://doi.org/10.1159/000534698","url":null,"abstract":"Introduction: Lipedematous scalp (LS) is a rare disorder characterized by thickening of the adipose subcutaneous scalp layer without associated hair loss. To date, there have been fewer than 100 reported cases of LS. LS occurring in siblings has not been previously reported. Case Presentation: We present a 58-year-old and 63-year-old pair of black Caribbean female siblings with LS. Scalp thickness on ultrasound of the vertex in each case was 12 mm and 11 mm from skin to periosteum, respectively (normal range: 5–6 mm). Histopathological analysis in the younger sibling demonstrated prominent fat, high in the dermis around hair follicles, with follicular distortion and focal perifollicular fibrosis. Co-morbidities in the younger sibling were obesity (body mass index [BMI] 39.0), paranoid schizophrenia, and bipolar disorder; the older sibling was overweight (BMI 26.0) with co-morbidities of hypercholesterolemia, type 2 diabetes mellitus, hypomania, and migraines; both siblings were taking psychiatric medication. Conclusion: We present an unusual case of LS in a pair of female siblings, adding to the limited existing evidence that there may be a genetic role in the pathogenesis of LS. Furthermore, both siblings in this case had psychiatric co-morbidities and were taking psychiatric medication, which have not been previously identified as associations of LS.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"85 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK Inhibitors in the Treatment of Lichen Planopilaris JAK抑制剂治疗扁平苔藓的研究

Skin Appendage Disorders Pub Date : 2023-11-09 DOI: 10.1159/000534631

Maryam Nasimi, Mahshid Sadat Ansari

{"title":"JAK Inhibitors in the Treatment of Lichen Planopilaris","authors":"Maryam Nasimi, Mahshid Sadat Ansari","doi":"10.1159/000534631","DOIUrl":"https://doi.org/10.1159/000534631","url":null,"abstract":"Background: Lichen planopilaris (LPP) is an autoimmune disorder leading to lymphocytic cicatricial alopecia. Different agents such as hydroxychloroquine, methotrexate, cyclosporine, and mycophenolate mofetil have been tried to control hair loss with limited efficacy. JAK inhibitors are immune-modulating drugs which interfere with the JAK-STAT signaling pathway in lymphocytes and are used in treatment of inflammatory conditions such as rheumatoid arthritis and alopecia areata. Summary: Our aim was to determine effectiveness of JAK inhibitors in LPP and its clinical variant, frontal fibrosing alopecia. A literature search was conducted using PubMed, Google Scholar, and Cochrane databases. A total of 7 articles describing 35 patients were found. Although data on treatment are limited to retrospective studies and case reports, JAK inhibitors can be considered a new therapeutic option, especially in recalcitrant cases. Large prospective studies and randomized control trials are needed to provide further evidence supporting efficacy. Key Messages: Besides the fact that data on the treatment of LPP and FFA with JAK inhibitors are limited to retrospective studies and case reports, but JAK inhibitors can be considered as a new therapeutic option especially in recalcitrant cases.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135240743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Efficacy of Monthly 308 nm Excimer Lamp Double-Stacked Pulse Adjusted Therapy for Alopecia Areata 评价每月308 nm准分子灯双叠脉冲调节治疗斑秃的疗效

Skin Appendage Disorders Pub Date : 2023-11-03 DOI: 10.1159/000533993

Elva Dalia Rodríguez-Acosta, Diego Fernandez Nieto, Emilio Berna-Rico, Hector Ricardo Galván-García, Ruth Galit Meza-Castro, Ana Karen Rosales-Lerma, Andrea Viridiana Guerrero-Cervantes, Hassiel Aurelio Ramírez-Marín

{"title":"Assessing the Efficacy of Monthly 308 nm Excimer Lamp Double-Stacked Pulse Adjusted Therapy for Alopecia Areata","authors":"Elva Dalia Rodríguez-Acosta, Diego Fernandez Nieto, Emilio Berna-Rico, Hector Ricardo Galván-García, Ruth Galit Meza-Castro, Ana Karen Rosales-Lerma, Andrea Viridiana Guerrero-Cervantes, Hassiel Aurelio Ramírez-Marín","doi":"10.1159/000533993","DOIUrl":"https://doi.org/10.1159/000533993","url":null,"abstract":"Introduction: Alopecia areata (AA) is an autoimmune disease characterized by T cell‐mediated attack on the hair follicle. Although there are a wide range of therapies, the majority of them are not satisfactory due to side effects, pain due to intralesional injections or limited efficacy. In this study, we sought to evaluate the efficacy, influence factors, and safety of 308 nm excimer lamp used in a monthly basis in a double-stacked pulse manner for the treatment of AA. Methods: This was a prospective study, using 308 nm excimer lamp in a double-stacked pulse therapy for AA. The primary endpoint was the improvement in SALT score. Results: A total of 40 patients with AA were enrolled in this study. Forty (100%) patients achieved clinical response. Hyperpigmentation and erythema occurred on the treated alopecic areas of all patients but they were considered tolerable. Patients of younger age or with a smaller area of affection had a better overall treatment response. Conclusion: 308 nm excimer lamp therapy is an excellent option for single or multiple AA because it achieves a good clinical response with less adverse effects than other therapies. This therapy may be useful for low-income countries where new JAK inhibitors are not available, however, for patients with extensive hair loss, it is not as effective and thus, it may be unfit for patients with alopecia totalis and alopecia universals.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"97 1‐2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135818823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Interest in Oral Minoxidil for Hair Loss Treatment Following Publication of August 2022 New York Times Article: A Google Trends Analysis 在2022年8月《纽约时报》文章发表后，人们对口服米诺地尔治疗脱发的兴趣增加:谷歌趋势分析

Skin Appendage Disorders Pub Date : 2023-11-02 DOI: 10.1159/000534526

Noelle Desir, Amar D. Desai, Shari R. Lipner

{"title":"Increased Interest in Oral Minoxidil for Hair Loss Treatment Following Publication of August 2022 New York Times Article: A Google Trends Analysis","authors":"Noelle Desir, Amar D. Desai, Shari R. Lipner","doi":"10.1159/000534526","DOIUrl":"https://doi.org/10.1159/000534526","url":null,"abstract":"Introduction: Androgenetic alopecia (AGA) is the most common form of hair loss, with negative impact on patient quality of life. Oral minoxidil is used off-label for AGA treatment. We hypothesized increased public interest in oral minoxidil for hair loss treatment following the New York Times (NYT) Article on oral minoxidil: “An Old Medicine Grows New Hair for Pennies a Day, Doctors Say.” The objective of this study was to quantify interest in oral minoxidil for hair loss treatment before and after the NYT article and help inform dermatologists about treatments of interest to their patients. Method: We performed a cross-sectional analysis of Google Trends evaluating relative prevalence of “oral minoxidil,” “minoxidil,” “hair loss,” and “Rogaine®” 2/2022–5/2023. t tests compared mean search volume and linear regression analysis quantified changes in public interest over time. Results: Oral minoxidil and minoxidil search volumes increased from 0.86 to 3.00 and 22.43 to 32.60, respectively, before and after the NYT article (both p &lt; 0.05). Minoxidil searches continually increased by 500,000 searches per month (p &lt; 0.001). Conclusions: There was a significant and sustained increase in Google searches for oral minoxidil after publication of the NYT article, indicating increased patient interest. Larger clinical trials are needed to provide evidence-based care to AGA patients.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135876463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0