Skin Appendage Disorders最新文献

筛选
英文 中文
Pyogenic Granuloma with Onychomadesis following Plastic Cast Immobilization: A Case Report in a Pediatric Patient. 塑料石膏固定后化脓性肉芽肿伴甲发育:1例儿科患者报告。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-06-01 Epub Date: 2025-12-11 DOI: 10.1159/000550021
Dustine Reich, Rachel E Christensen, Shari R Lipner
{"title":"Pyogenic Granuloma with Onychomadesis following Plastic Cast Immobilization: A Case Report in a Pediatric Patient.","authors":"Dustine Reich, Rachel E Christensen, Shari R Lipner","doi":"10.1159/000550021","DOIUrl":"10.1159/000550021","url":null,"abstract":"<p><strong>Introduction: </strong>Pyogenic granuloma development following plaster cast immobilization is rare, with only 17 reported cases previously.</p><p><strong>Case presentation: </strong>Here, we present a case of the youngest patient to date, an 11-year-old male, who developed a pyogenic granuloma on his left thumbnail after cast immobilization for a left wrist and elbow fracture. His fracture was complicated by wound infection, ulnar nerve injury, and avascular necrosis. Following cast removal, a pyogenic granuloma developed on his left thumbnail that was recalcitrant to treatment with timolol, and surgical resection was recommended. Additionally, he had onychomadesis of all nails on his left hand.</p><p><strong>Conclusion: </strong>This case highlights an association between pyogenic granuloma development and plaster cast immobilization in pediatric patients.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"232-237"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type B Digital Mucous Cysts Can Present with Cuticle Thickening as a Clinical Clue. B型指黏膜囊肿可表现为表皮增厚作为临床线索。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-21 DOI: 10.1159/000552652
Benjamin Y Li, Megan Hauptman, Aaron J Russell, Julia O Baltz, Nathaniel J Jellinek, Julie E Mervak
{"title":"Type B Digital Mucous Cysts Can Present with Cuticle Thickening as a Clinical Clue.","authors":"Benjamin Y Li, Megan Hauptman, Aaron J Russell, Julia O Baltz, Nathaniel J Jellinek, Julie E Mervak","doi":"10.1159/000552652","DOIUrl":"10.1159/000552652","url":null,"abstract":"<p><strong>Introduction: </strong>Type B digital mucous cysts (DMCs) exert pressure over the nail matrix, leading to longitudinal nail plate groove. In the authors' experience, focal hyperkeratosis of the proximal nail fold (PNF) in type B DMC is frequently observed. We analyzed clinical images in the literature to assess how often this feature was present, if noted in the figure caption, and aimed for clinical description of this finding.</p><p><strong>Methods: </strong>We performed a search of DMC images from PubMed literature and nail atlases. Consensus for DMC type, presence of PNF hyperkeratosis, hyperkeratosis described in the figure caption, and etiology of hyperkeratosis was performed.</p><p><strong>Results: </strong>Of available images, 33.9% were determined to be type B DMC; of these, 53.8% had presence of PNF hyperkeratosis. There was consensus that a majority (61.9%) of the hyperkeratotic findings were due to cuticle thickening, and only one figure caption mentioned PNF hyperkeratosis.</p><p><strong>Conclusion: </strong>Type B DMCs often feature focal hyperkeratosis at the PNF. A review of type B DMC images revealed that this hyperkeratosis was mostly due to cuticle thickening, suggesting a reaction of the eponychium in response to the mass effect within the PNF. Bringing this characteristic to the attention of practicing physicians may aid in clinical diagnosis.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body-Focused Repetitive Behaviors in Patients with Neurofibromatosis Type 1: A National Cross-Sectional Survey-Based Study. 1型神经纤维瘤病患者的身体聚焦重复行为:一项基于全国横断面调查的研究
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-21 DOI: 10.1159/000552579
Natalia Chalupczak, Nuran C Golbasi, Kaya L Curtis, Shari R Lipner
{"title":"Body-Focused Repetitive Behaviors in Patients with Neurofibromatosis Type 1: A National Cross-Sectional Survey-Based Study.","authors":"Natalia Chalupczak, Nuran C Golbasi, Kaya L Curtis, Shari R Lipner","doi":"10.1159/000552579","DOIUrl":"10.1159/000552579","url":null,"abstract":"<p><strong>Introduction: </strong>Body-focused repetitive behaviors (BFRBs), including skin picking, onychophagia, onychotillomania, and trichotillomania, are psychodermatologic conditions characterized by repetitive self-injury. While neuropsychiatric comorbidities are common in neurofibromatosis type 1 (NF1), prevalence and quality-of-life (QoL) impact of BFRBs in these individuals are underexplored. We aimed to characterize BFRB prevalence and assess association with dermatology-related QoL in a national NF1 cohort.</p><p><strong>Methods: </strong>A voluntary online survey was distributed to NF1 registry members. Participants reported BFRBs and dermatology-related QoL using the Dermatology Life Quality Index (DLQI). Multivariable logistic regression assessed predictors of moderate-severe QoL impairment.</p><p><strong>Results: </strong>Among 143 respondents, 73.4% reported ≥1 BFRB. Skin picking was most common (55.3%), followed by onychophagia (39.8%), onychotillomania (35.2%), and trichotillomania (17.9%). Respondents with any BFRB had significantly worse QoL vs. those without (mean DLQI score 7.28 vs. 4.03; <i>p</i> < 0.001). Any BFRB increased odds of moderate-severe impairment (OR 4.88; <i>p</i> = 0.007) with higher odds per additional BFRB (OR 1.93; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>We found that BFRBs are highly prevalent and independently associated with poorer QoL in NF1 patients. Screening for BFRBs during dermatologic evaluation in patients with NF1 may improve early recognition and reduce grooming-related skin and nail injury.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Value of Trichoscopy and Histopathology in the Diagnosis of Post-COVID-19 Telogen Effluvium. 毛发镜和组织病理学在covid -19后休止期积液诊断中的价值。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-21 DOI: 10.1159/000552511
María Abril Martínez-Velasco, Curtis Thompson, Antonella Tosti, Marla Daniela Olivas-Altamirano, Hassiel Aurelio Ramírez-Marín
{"title":"The Value of Trichoscopy and Histopathology in the Diagnosis of Post-COVID-19 Telogen Effluvium.","authors":"María Abril Martínez-Velasco, Curtis Thompson, Antonella Tosti, Marla Daniela Olivas-Altamirano, Hassiel Aurelio Ramírez-Marín","doi":"10.1159/000552511","DOIUrl":"10.1159/000552511","url":null,"abstract":"<p><strong>Introduction: </strong>Telogen effluvium (TE) is a recognized sequel of COVID-19 infection, often exhibiting an accelerated onset that suggests a pathomechanism distinct from classical TE. This study aims to define the unique trichoscopic and histopathological features of post-COVID-19 TE and to correlate these novel findings with prior systemic disease severity.</p><p><strong>Methods: </strong>Trichoscopy images and pathology specimens of 13 patients (12 women, 1 man; mean age 46.2 years) who developed TE after PCR-confirmed COVID-19 infection were retrospectively reviewed. Statistical analysis correlated trichoscopic findings with the need for supplementary oxygen during acute infection.</p><p><strong>Results: </strong>Trichoscopy showed thick, livedoid arborizing vessels in most cases, with giant serpiginous vessels in 38% of patients. The presence of giant vessels showed a strong statistical correlation with the requirement of supplementary oxygen during hospitalization (<i>p</i> = 0.001). Histopathology confirmed a catagen/telogen shift and consistently revealed a superficial perivascular and perifollicular lymphocytic infiltrate in all cases.</p><p><strong>Conclusion: </strong>Vascular patterns can distinguish post-COVID-19 TE. The perifollicular lymphocytic infiltrate supports a direct viral or localized immune-mediated insult.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-Dimensional Printing in Trichology: A Narrative Mini-Review - Where Are We Now? 三维打印在毛发学:一个叙事的小回顾-我们现在在哪里?
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-21 DOI: 10.1159/000552653
Fernanda Múnera Yamhure, Ramon Grimalt
{"title":"Three-Dimensional Printing in Trichology: A Narrative Mini-Review - Where Are We Now?","authors":"Fernanda Múnera Yamhure, Ramon Grimalt","doi":"10.1159/000552653","DOIUrl":"10.1159/000552653","url":null,"abstract":"<p><strong>Background: </strong>Alopecia is one of the most prevalent medical conditions worldwide, and traditional therapies, such as topical minoxidil and hair transplants, are limited by pharmacological efficacy and donor-site availability. With technology evolving at a rapid pace, emerging bioengineering strategies are being developed, one of which is three-dimensional (3D) bioprinting of hair follicles. This review focuses on the materials, process, applications, and limitations of 3D printing in trichology, which aims to mimic real hair follicles to produce them de novo.</p><p><strong>Summary: </strong>This review identifies the synthetic and natural polymers currently used to make bioinks for 3D bioprinting and describes the process where cell populations - primarily dermal papilla cells - are layered to form a dermis and epidermis. The text then explores how this technology can be applied in androgenetic alopecia and full-thickness wound healing, as well as providing a template for surgical practice and an alternative to animal testing. Finally, it addresses the current limitations of this technology, such as its high maintenance cost, finding a balance between viability and printability, and the present inability to apply it to humans.</p><p><strong>Key messages: </strong>3D bioprinting is an encouraging preclinical approach to overcoming treatment limitations for such a prevalent condition as alopecia. Its versatility would not only help in the treatment of alopecia but also in creating personalized prosthetics, guiding surgical techniques, and improving scientific research. However, while promising in a laboratory setting, further optimization of the bioink as well as cost of maintenance are required before it can be applied to clinical practice.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delays in Diagnosis of Alopecia Areata. 斑秃诊断的延误。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-21 DOI: 10.1159/000552679
Katherine Sanchez, Samantha Gregoire, Ursula Biba, Lana Salloum, Lisa Anderson, Monique Margaret Waldman, Natasha A Mesinkovska, Arash Mostaghimi
{"title":"Delays in Diagnosis of Alopecia Areata.","authors":"Katherine Sanchez, Samantha Gregoire, Ursula Biba, Lana Salloum, Lisa Anderson, Monique Margaret Waldman, Natasha A Mesinkovska, Arash Mostaghimi","doi":"10.1159/000552679","DOIUrl":"10.1159/000552679","url":null,"abstract":"<p><strong>Introduction: </strong>Diagnostic delays in alopecia areata (AA) are often preventable and may be compounded by factors that have not been fully elucidated. Our objective was to identify potential associations and to characterize diagnostic delay of AA that extends beyond 1 year.</p><p><strong>Methods: </strong>Patients with AA were recruited via online survey. A multivariable linear regression was performed to analyze diagnostic delay greater than 1 year while controlling for age, sex at birth, race, income, health insurance, and employment. A sensitivity analysis was performed to compare delays of over 9 months versus 1 year.</p><p><strong>Results: </strong>Regression analysis revealed associations between white race (OR 0.46, 95% CI [0.27-0.80], <i>p</i> = 0.006), annual income above the median of $75,000 (OR 0.56, 95% CI [0.32-0.99], <i>p</i> = 0.046), and having health insurance (OR 0.32, 95% CI [0.11-0.92], <i>p</i> = 0.034), with lower odds of diagnostic delay beyond 1 year. Sensitivity analysis indicated that these associations, except health insurance, held true even at 9-month thresholds.</p><p><strong>Conclusion: </strong>Limitations include survey demographics and cross-sectional design, limiting causal inference. Socioeconomic factors, including race, income, and insurance coverage, extend diagnostic delay in AA. Addressing disparities could improve timely diagnosis for AA, emphasizing the need for further investigation of healthcare barriers.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLP-1 Receptor Agonists in Hidradenitis Suppurativa: Time to Treat the Whole Patient. GLP-1受体激动剂治疗化脓性汗腺炎:需要对整个患者进行治疗。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-16 DOI: 10.1159/000552598
Gerardo Uriel Viquez Burboa, Miguel Ángel Rafael Flores Guillén
{"title":"GLP-1 Receptor Agonists in Hidradenitis Suppurativa: Time to Treat the Whole Patient.","authors":"Gerardo Uriel Viquez Burboa, Miguel Ángel Rafael Flores Guillén","doi":"10.1159/000552598","DOIUrl":"10.1159/000552598","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a disproportionately high burden of metabolic comorbidities, including obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), dyslipidaemia, and polycystic ovary syndrome. Despite this, clinical management of HS has historically remained siloed within dermatology, with insufficient integration of cardiometabolic risk management.</p><p><strong>Summary: </strong>GLP-1 receptor agonists (GLP-1 RAs) - a drug class now established for T2DM, obesity, and cardiovascular risk reduction - have recently emerged as candidate agents for HS. A systematic review published in 2024 and two pivotal real-world studies published in 2025 provide preliminary evidence that GLP-1 RAs improve HS disease activity through both weight loss and direct anti-inflammatory mechanisms. We argue that this evidence base is already sufficient to justify a paradigm shift: GLP-1 RAs should be considered as adjunctive components of a multidisciplinary treatment strategy for HS patients with concurrent cardiometabolic disease. We propose a practical clinical framework for patient selection and monitoring and call for dedicated randomised controlled trials.</p><p><strong>Key messages: </strong>Metabolic comorbidities are mechanistically linked to HS pathogenesis and are inadequately addressed in current clinical practice. GLP-1 RAs offer dual benefit in HS - improving both metabolic outcomes and HS disease activity. Dermatologists should screen every HS patient for cardiometabolic comorbidities and advocate for GLP-1 RA therapy in eligible patients as part of a multidisciplinary approach.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lasers and Energy-Based Devices in the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis. 激光和能量装置治疗雄激素性脱发:系统回顾和荟萃分析。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-15 DOI: 10.1159/000551411
Mohammed Alahmadi, Sara Alghamdi, Shatha Albyali, Reenad Alharbi, Dalia Alanazi, Amal Altamimi, Rawan Aldahash, Ruaa Alharithy
{"title":"Lasers and Energy-Based Devices in the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis.","authors":"Mohammed Alahmadi, Sara Alghamdi, Shatha Albyali, Reenad Alharbi, Dalia Alanazi, Amal Altamimi, Rawan Aldahash, Ruaa Alharithy","doi":"10.1159/000551411","DOIUrl":"https://doi.org/10.1159/000551411","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia (AGA) is a common progressive disorder with limited response to conventional pharmacological therapy. Energy-based devices (EBDs), including low-level laser therapy (LLLT) and fractional lasers, have emerged as minimally invasive alternatives or adjuncts to traditional treatments. We aimed to evaluate the efficacy and safety of lasers and EBDs in the management of AGA.</p><p><strong>Methods: </strong>This is a systematic review and a meta-analysis that was conducted in accordance with PRISMA guidelines.</p><p><strong>Results: </strong>A total of 3,298 patients were included across the 37 studies. Pooled analysis of LLLT demonstrated a mean increase in hair density of 18.56 hairs/cm<sup>2</sup> and shaft thickness of 10.62 µm compared with sham. When combined with minoxidil, LLLT yielded a greater improvement in hair density than minoxidil alone (mean difference +11.75 hairs/cm<sup>2</sup>). Fractional laser monotherapy, including ablative fractional CO<sub>2</sub> laser and non-ablative fractional laser, increased density by 102.23 hairs/cm<sup>2</sup> and thickness by 5.93 µm. However, combination protocols of ablative fractional CO<sub>2</sub> laser and non-ablative fractional thulium fiber and Er:glass laser with minoxidil, PRP, or growth factors produced a mean density increase of 33.6 hairs/cm<sup>2</sup> and a greater improvement in hair shaft thickness (+11.22 µm), along with a higher clinician-rated improvement rate (95.3% vs. 77.2% for monotherapy). Adverse events were mild and transient.</p><p><strong>Conclusion: </strong>LLLT and fractional lasers are effective and safe for the treatment of AGA. However, fractional lasers, particularly when combined with topical agents such as minoxidil, PRP, or growth factors, demonstrate the most significant improvements in hair density and thickness, outperforming LLLT and monotherapy approaches.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive Effects of Platelet-Rich Plasma and Systemic Therapies in Androgenetic Alopecia: A Retrospective Study. 富血小板血浆和全身治疗对雄激素性脱发的累加效应:一项回顾性研究。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-05-08 DOI: 10.1159/000552428
Anna L Brinks, Carli Needle Lawrence, Derek Maas, Caitlin A Kearney, Nnaemeka Anyanwu, Deesha D Desai, Ambika Nohria, Michelle Sikora, Christina S Oh, Jerry Shapiro, Kristen I Lo Sicco
{"title":"Additive Effects of Platelet-Rich Plasma and Systemic Therapies in Androgenetic Alopecia: A Retrospective Study.","authors":"Anna L Brinks, Carli Needle Lawrence, Derek Maas, Caitlin A Kearney, Nnaemeka Anyanwu, Deesha D Desai, Ambika Nohria, Michelle Sikora, Christina S Oh, Jerry Shapiro, Kristen I Lo Sicco","doi":"10.1159/000552428","DOIUrl":"10.1159/000552428","url":null,"abstract":"<p><strong>Introduction: </strong>Established treatments for androgenetic alopecia (AGA) include low-dose oral minoxidil (LDOM), spironolactone, finasteride, dutasteride, and platelet-rich plasma (PRP). While PRP is often combined with topical minoxidil, studies on its use with systemic agents are limited. This study compares trichometric outcomes and side effects between PRP monotherapy and PRP plus systemic therapy.</p><p><strong>Methods: </strong>An IRB-approved retrospective review was conducted of NYU AGA patients treated between 11/1/17 and 8/1/25. Changes in hair density (hairs/cm<sup>2</sup>) and width (µm) were assessed from baseline to final follow-up among patients receiving PRP alone or PRP with LDOM, spironolactone, finasteride, or dutasteride. AGA severity was determined via Hamilton-Norwood or Ludwig scale. Mann-Whitney U tests, Fisher exact tests, and multivariate linear regression were performed.</p><p><strong>Results: </strong>Fifty-five patients met inclusion criteria (65.5% female, mean age 49). Compared to monotherapy (<i>n</i> = 6), combination therapy (<i>n</i> = 49) showed greater, though not statistically significant, gains in density (+6.06 hairs/cm<sup>2</sup>, <i>p</i> = 0.703) and width (+3.59 µm, <i>p</i> = 0.460). Controlling for treatment type, moderate AGA predicted significantly greater density improvement (+25.11 hairs/cm<sup>2</sup>, <i>p</i> = 0.040).</p><p><strong>Conclusions: </strong>Combination therapy showed numerically higher but statistically nonsignificant improvements without increased adverse effects. These findings support further prospective studies to optimize combination regimens and patient selection by AGA severity.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissecting Cellulitis in Children and Adolescents: A Comprehensive Review. 儿童和青少年夹层蜂窝织炎:综合综述。
IF 1.3
Skin Appendage Disorders Pub Date : 2026-04-28 DOI: 10.1159/000552195
Mildred Acosta-Sau, Arturo Lopez Yañez-Blanco, Flavia Oliveira Xavier de Brito, Daniel Fernandes Melo
{"title":"Dissecting Cellulitis in Children and Adolescents: A Comprehensive Review.","authors":"Mildred Acosta-Sau, Arturo Lopez Yañez-Blanco, Flavia Oliveira Xavier de Brito, Daniel Fernandes Melo","doi":"10.1159/000552195","DOIUrl":"https://doi.org/10.1159/000552195","url":null,"abstract":"<p><strong>Background: </strong>Dissecting cellulitis is a chronic primary scarring alopecia characterized by pustules, nodules, abscesses, and sinus tracts that progress to permanent hair loss. Its prevalence is low, and reports in pediatric populations are scarce.</p><p><strong>Summary: </strong>This review aims to expand current understanding of dissecting cellulitis in pediatric population, highlighting it as a potential differential diagnosis at this age group to enable early diagnosis and prevent complications. A literature review was conducted using PubMed, Google Scholar, and SciELO, employing English and Spanish terms: \"dissecting cellulitis,\" \"children,\" \"pediatrics,\" and \"<i>perifolliculitis capitis abscedens et suffodiens</i>,\" covering publications from 1999 to 2025. Dissecting cellulitis is an uncommon disease in pediatric patients. Its pathogenesis is multifactorial, and it is clinically characterized by papules and pustules that evolve into nodules, abscesses, and fistulous tracts, leading to disfiguring scars and alopecia. Diagnosis is primarily clinical, supported by trichoscopy and histopathological examination. Differential diagnosis with other conditions is crucial to prevent its irreversible course. Although no standardized treatment protocol exists, multiple therapeutic options have been successfully employed in pediatric cases.</p><p><strong>Key messages: </strong>Recognizing that dissecting cellulitis can occur in pediatric patients is essential to achieve early diagnosis and treatment, thereby preventing irreversible sequelae with significant psychosocial impact.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13300027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书