杜他雄胺输注治疗男性雄激素性脱发的新给药技术:MMP®。

IF 1.3 Q3 DERMATOLOGY
Luciana Gasques, Alice Lima, Mariana Lima, Antonella Tosti, Marcio Silva, Marina Barletta
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引用次数: 0

摘要

简介:MMP®(microinfus o de medicamentos na pele的葡萄牙语首字母缩写[即,将药物微量注入皮肤])是一种使用微针将药物注入皮肤的新型药物输送技术。头皮微输液是一种很有前途的脱发干预措施。目的:本研究的目的是评价MMP®技术微输注度他雄胺与微输注生理盐水(安慰剂)在男性雄激素性脱发(AGA)患者中的疗效和安全性。这是第一个比较微输注MMP®使用杜他雄胺与安慰剂治疗AGA的研究。方法:对8例成年男性AGA患者进行前瞻性、多中心、对照临床试验。每30天使用MMP®三次应用度他雄胺或安慰剂(0.9%生理盐水溶液)。三位盲法皮肤科医生和患者对治疗前后的照片进行分析。评价其疗效和安全性。结果:两组间临床评价无统计学差异。然而,患者自我评估报告了杜他雄胺组顶点面积的显著改善。结论:MMP®技术滴注杜他雄胺治疗男性AGA疗效显著。MMP®微针治疗男性AGA有效,无需任何药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dutasteride Infusion in Male Androgenetic Alopecia Using a Novel Drug Delivery Technique: MMP®.

Introduction: MMP® (the Portuguese acronym for microinfusão de medicamentos na pele [i.e., microinfusion of drugs into the skin]) is a novel drug delivery technique that uses microneedling to infuse drugs into the skin. Scalp microinfusion is a promising intervention for hair loss.

Aim: The aim of the study was to evaluate the efficacy and safety of microinfusion of dutasteride with the MMP® technique compared with microinfusion of saline solution (placebo) in men with androgenetic alopecia (AGA). This is the first study that compared microinfusion with MMP® using dutasteride versus placebo for the treatment of AGA.

Methods: A prospective, multicenter, controlled clinical trial was conducted in eight (8) adult male patients with AGA. Three applications of dutasteride or placebo (saline solution 0.9%) using the MMP® were made every 30 days. Photos pre- and posttreatment were analyzed by three blinded dermatologists and the patient. Efficacy and safety were evaluated.

Results: No statistical difference in the clinical assessment was found between the groups. However, patient self-assessment reported marked improvement in the vertex area in the dutasteride group.

Conclusion: Dutasteride microinfusion using the MMP® technique is effective in treating male AGA. Microneedling with MMP® without any medication is effective in treating male AGA.

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CiteScore
2.00
自引率
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