Skin Appendage Disorders最新文献_第4页

Basal Cell Carcinoma Arising at the Site of Repeated Microneedling-Induced Microtrauma for Androgenetic Alopecia: A Case Report. 雄激素源性脱发反复微针致微创伤部位基底细胞癌一例报告。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-24 DOI: 10.1159/000552147

Ahmet Taha Aydemir, Handan Merve Erol Mart, Bengu Nisa Akay

引用次数: 0

Clinical and Onychoscopic Evaluation of Nail Changes in Patients with Erythroderma. 红皮病患者甲改变的临床及甲镜评价。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-24 DOI: 10.1159/000551846

Abhay Goyal, Shikha Bansal, Parth Vijay Rathi, Anshuman Dash

{"title":"Clinical and Onychoscopic Evaluation of Nail Changes in Patients with Erythroderma.","authors":"Abhay Goyal, Shikha Bansal, Parth Vijay Rathi, Anshuman Dash","doi":"10.1159/000551846","DOIUrl":"https://doi.org/10.1159/000551846","url":null,"abstract":"Introduction: Erythroderma is a severe inflammatory dermatosis involving over 90% of the body surface. Nail changes are common and reflect underlying dermatoses, systemic influences, and disease chronicity. However, their detailed characterization, particularly on onychoscopy, remains insufficiently studied.Methods: This cross-sectional study was conducted at a tertiary referral hospital in India over 18 months. Consecutive clinically diagnosed, untreated erythroderma cases (≥4 weeks off therapy) were enrolled. Comprehensive clinical and onychoscopic evaluation of all 20 nails was performed, with correlation of findings to disease etiology, severity, and chronicity.Results: Fifty patients were assessed, comprising 998 nails (498 fingernails, 500 toenails). Nail abnormalities were present in 90.08% of nails. Psoriasis (44%), atopic dermatitis (10%), and idiopathic erythroderma (10%) were leading etiologies. Common clinical findings included ragged cuticles, longitudinal ridging, scaling, pitting, and nail dystrophy. Onychoscopic abnormalities were seen in 86% of fingernails and 94% of toenails, most frequently involving proximal nail fold. Chronic erythroderma showed significantly greater nail plate involvement, whereas acute disease demonstrated vascular changes of hyponychium and nail bed, better visualized on onychoscopy. Nail fold capillaroscopy was attempted in all patients but was often limited by scaling.Conclusion: Nail involvement is highly prevalent in erythroderma. Routine incorporation of onychoscopy enhances detection of subtle etiologic and temporal patterns, supporting refined clinical assessment and diagnostic decision-making.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life in Brazilian Patients with Alopecia Areata and Their Caregivers. 巴西斑秃患者及其护理者的生活质量。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-24 DOI: 10.1159/000552060

Isabela Peron Melhado, Maria Cecília Rivitti-Machado, Isabella Doche

{"title":"Quality of Life in Brazilian Patients with Alopecia Areata and Their Caregivers.","authors":"Isabela Peron Melhado, Maria Cecília Rivitti-Machado, Isabella Doche","doi":"10.1159/000552060","DOIUrl":"https://doi.org/10.1159/000552060","url":null,"abstract":"Introduction: Alopecia areata (AA) has a major psychological impact, yet Brazilian data on patients' and caregiver's quality of life (QoL) are lacking. We aimed to assess QoL in patients with AA and their caregivers and identify clinical and socioeconomic correlates.Methods: A cross-sectional study including 118 patients (83 adults, 35 children/adolescents) aged ≥4 years with active scalp AA and 58 caregivers was performed at a tertiary dermatology center (2022-2024). QoL was evaluated with DLQI, CDLQI, and FDLQI. Disease severity was scored with Severity of Alopecia Tool (SALT) II. Sociodemographic and clinical data were analyzed using parametric and nonparametric tests (p ≤ 0.05).Results: Participants were predominantly female (63.6%) and of mixed race (53.5%), with mean age of 27.6 years. Mean SALT II was 33.9%. Multifocal (39.3%) AA predominated. QoL impact was moderate in adults (median DLQI 6; IQR 3-10) and mild in youth (median CDLQ 5; IQR 2-8) but greater among caregivers (median FDLQI 9; IQR 6-14). Patient-caregivers QoL scores correlated positively (Rho = 0.48, p < 0.001). Dermatologic comorbidities worsened QoL in both groups.Conclusion: AA exerts substantial psychosocial burden on whole family. Caregivers experience higher impairment than patients, underscoring the need for family-centered interventions in Latin America.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric Outcomes after GLP-1 Receptor Agonists versus Metformin in Hidradenitis Suppurativa. GLP-1受体激动剂与二甲双胍治疗化脓性汗腺炎的精神结局。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-24 DOI: 10.1159/000551916

Raslina Shrestha, Hue T T Tran, Jun Ma, Duc L Van, David A Wetter, Rozalina G McCoy, Giang H Nguyen

{"title":"Psychiatric Outcomes after GLP-1 Receptor Agonists versus Metformin in Hidradenitis Suppurativa.","authors":"Raslina Shrestha, Hue T T Tran, Jun Ma, Duc L Van, David A Wetter, Rozalina G McCoy, Giang H Nguyen","doi":"10.1159/000551916","DOIUrl":"https://doi.org/10.1159/000551916","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with obesity and a high burden of psychiatric comorbidity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and metformin are commonly prescribed for metabolic disease and have anti-inflammatory effects, prompting interest in their use among patients with HS. However, recent reports have raised concerns regarding potential psychiatric adverse effects of GLP-1RAs. We evaluated psychiatric outcomes following GLP-1RA versus metformin initiation among adults with HS.Methods: We conducted a retrospective cohort study within the NIH All of Us Research Program (Controlled Tier v8) using a new-user, active-comparator design. Adults with HS were identified using validated SNOMED concepts. Incident users of GLP-1RAs were compared with incident users of metformin after a 365-day washout. The primary outcome was the first psychiatric diagnosis within 12 months of treatment initiation. Stabilized inverse probability of treatment weighting (IPTW) was used to control for confounding. Effect estimates included 12-month cumulative risks, risk differences (RD), risk ratios (RR), and IPTW-weighted Cox proportional hazards models.Results: The weighted analytic cohort included 77 GLP-1RA users and 233 metformin users. At 12 months, psychiatric diagnoses occurred in 61.3% of GLP-1RA users versus 51.1% of metformin users (RD + 10.2 percentage points; RR 1.20; 95% CI: 0.95-1.52). The hazard ratio for time to first psychiatric diagnosis was 1.26 (95% CI: 0.90-1.78). Divergence between groups occurred primarily within the first 90 days after initiation.Conclusion: Among adults with HS, GLP-1RA initiation was associated with a modest, nonsignificant increase in psychiatric diagnoses compared with metformin. These findings are hypothesis-generating and warrant further investigation.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor Regarding the Article "Ayurvedic Treatments for Hair Disorders: A Narrative Review". 致编辑关于文章“阿育吠陀治疗头发疾病：叙述回顾”的信。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-16 DOI: 10.1159/000551827

Radhika Gupta, Isabella Zappi, Archie Spindler, Derek Maas, Anna Haemel, Jerry Shapiro, Daniel R Mazori, Kristen I Lo Sicco

引用次数: 0

Exosomes as Regenerative Therapeutics in Non-Scarring Alopecia: Current Perspectives and Future Directions. 外泌体作为非瘢痕性脱发的再生疗法：目前的观点和未来的方向。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-14 DOI: 10.1159/000551007

Aishwarya Lakshmi Sekar, Monisha V

{"title":"Exosomes as Regenerative Therapeutics in Non-Scarring Alopecia: Current Perspectives and Future Directions.","authors":"Aishwarya Lakshmi Sekar, Monisha V","doi":"10.1159/000551007","DOIUrl":"https://doi.org/10.1159/000551007","url":null,"abstract":"Background: Non-scarring alopecias, including androgenetic alopecia and alopecia areata, are common hair loss disorders with significant psychosocial impact. Conventional treatments such as minoxidil, finasteride, corticosteroids, and platelet-rich plasma (PRP) often demonstrate variable efficacy, relapse rates, or adverse effects. Emerging interest in regenerative dermatology has positioned exosome-based therapy as a potential next-generation solution.Summary: This narrative review synthesizes current evidence from experimental, translational, and clinical studies evaluating the role of exosomes in hair regeneration. Exosomes, nanosized extracellular vesicles rich in proteins, nucleic acids, and lipids, modulate the hair follicle microenvironment through activation of Wnt/β-catenin signaling, promotion of angiogenesis, immunomodulation, and prolongation of the anagen phase. Preclinical investigations consistently demonstrate robust follicular regeneration, while early clinical studies report improvements in hair density, shaft diameter, and patient satisfaction with favorable short-term safety. Compared with PRP and cellular therapies, exosomes offer a potentially standardizable, cell-free, and scalable biologic approach. However, challenges persist regarding isolation methods, dosing protocols, delivery techniques, regulatory frameworks, and production costs.Key messages: Exosomes exhibit multimodal biological actions supporting hair follicle regeneration. Early clinical data show improvements in hair density, thickness, and growth with good safety. Exosomes represent a cell-free and potentially standardizable biologic approach with improved reproducibility compared with autologous therapies, although full standardization has not yet been achieved. Standardization, cost reduction, and high-quality trials are needed for clinical translation.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alopecia Areata Is Associated with Increased Risk of Infertility in a Retrospective Cohort Study Using TriNetX. 在一项使用TriNetX的回顾性队列研究中，斑秃与不孕风险增加有关。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-13 DOI: 10.1159/000551975

Alexa S Podolsky, Carolyn Goh, Shari R Lipner

{"title":"Alopecia Areata Is Associated with Increased Risk of Infertility in a Retrospective Cohort Study Using TriNetX.","authors":"Alexa S Podolsky, Carolyn Goh, Shari R Lipner","doi":"10.1159/000551975","DOIUrl":"10.1159/000551975","url":null,"abstract":"Introduction: Alopecia areata (AA) has been associated with adverse pregnancy outcomes, but its relationship with infertility remains poorly characterized. Given the prevalence and psychosocial impact of infertility and the reproductive implications of systemic AA therapies, we examined for potential associations between AA and infertility.Methods: A retrospective cohort study was conducted using the TriNetX research network, querying for female patients aged 18-45 years with AA and matched controls. Reproductive outcomes <10-years of diagnosis were compared between cohorts, excluding patients with pre-existing outcomes. AA patients were additionally compared with matched infertile controls. Sex hormone levels were analyzed using t tests.Results: A total of 31,404 AA patients and 31,404 matched controls were included. AA was associated with increased risk of infertility (risk ratio [RR] = 1.21, 95% confidence interval [CI]: 1.09-1.35) and decreased likelihood of pregnancy (RR = 0.78, 95% CI: 0.73-0.82) and in vitro fertilization (IVF) utilization (RR = 0.71, 95% CI: 0.52-0.99). Compared with infertile controls, AA patients had significantly lower IVF use (0.17% vs. 5.04%) and pregnancy rates (6.50% vs. 19.45%) (both p < 0.0001). AA patients had lower testosterone and dehydroepiandrosterone-sulfate levels (both p < 0.0001), though within reference ranges.Conclusion: AA was associated with increased infertility risk and reduced reproductive outcomes, suggesting broader reproductive implications beyond infertility alone. Multidisciplinary counseling and prospective studies incorporating reproductive intentions are warranted.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13278743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Risk of Trichotillomania in Neurofibromatosis Type 1: A Retrospective Cohort Study. 1型神经纤维瘤病患者拔毛癖风险增加：一项回顾性队列研究

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-10 DOI: 10.1159/000551904

Nuran C Golbasi, Natalia Chalupczak, Shari R Lipner

{"title":"Increased Risk of Trichotillomania in Neurofibromatosis Type 1: A Retrospective Cohort Study.","authors":"Nuran C Golbasi, Natalia Chalupczak, Shari R Lipner","doi":"10.1159/000551904","DOIUrl":"10.1159/000551904","url":null,"abstract":"Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder associated with substantial psychiatric comorbidity. Although repetitive and compulsive behaviors are reported in NF1, the risk of body-focused repetitive behaviors is understudied.Methods: We performed a retrospective cohort study using the TriNetX research network (2006-2026). On January 14, 2026, individuals with a first recorded diagnosis of NF1 were compared with matched controls. Patients with prior trichotillomania or skin-picking disorder were excluded. Cohorts were balanced using 1:1 propensity score matching for demographics, psychiatric comorbidities, and healthcare utilization. Five-year hazard ratios (HRs) were calculated using Cox proportional hazards models with Bonferroni correction.Results: After matching, 33,841 individuals were included in each cohort. NF1 was significantly associated with increased incidence of trichotillomania over 5 years compared with controls (HR 2.46; 95% CI: 1.43-4.22; p < 0.001), which remained significant after Bonferroni correction. No significant association was observed for skin-picking disorder (HR 1.25; 95% CI: 0.65-2.40; p = 0.670). In sensitivity analyses adjusting for ADHD, autism, and tic disorders, NF1 remained significantly associated with trichotillomania.Conclusion: We found that NF1 was associated with increased risk of trichotillomania. Increased clinical awareness and screening may help improve recognition and management and improve quality of life.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report with Hutchinson's Sign: What Could It Be Other than Melanoma in situ? 1例哈钦森氏征：除了原位黑色素瘤还可能是什么？

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-01 Epub Date: 2025-09-29 DOI: 10.1159/000548665

Güldehan Atış, Gaye Güldiken Doğruel, Pembegül Güneş, Eckart Haneke

引用次数: 0

Extensive Alopecia Mucinosa and Response to Brentuximab Vedotin: A Case Report. 广泛性粘液性脱发和布伦妥昔单抗维多汀的反应：1例报告。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-04-01 Epub Date: 2025-10-14 DOI: 10.1159/000548941

Claudia Montoya, Juan Camilo Marchán Cárdenas, Jairo Fuentes-Carrascal, Esperanza Meléndez, Beatriz Orozco-Sebá, Oscar Niebles

{"title":"Extensive Alopecia Mucinosa and Response to Brentuximab Vedotin: A Case Report.","authors":"Claudia Montoya, Juan Camilo Marchán Cárdenas, Jairo Fuentes-Carrascal, Esperanza Meléndez, Beatriz Orozco-Sebá, Oscar Niebles","doi":"10.1159/000548941","DOIUrl":"10.1159/000548941","url":null,"abstract":"Introduction: Follicular mucinosis (FM) is characterized by mucin deposition within hair follicles and sebaceous glands, sometimes causing irreversible alopecia. In adults, it is often secondary to cutaneous T-cell lymphoma (CTCL), particularly the folliculotropic mycosis fungoides (FMF) variant. Extensive scalp involvement is rare and may mimic inflammatory or infectious disorders, delaying diagnosis.Case presentation: A 64-year-old woman presented with progressive diffuse alopecia, suppurative scalp nodules, comedones, leonine facies, and multiple erythematous plaques. Initial biopsies elsewhere suggested tuberculoid leprosy, and multidrug therapy produced no improvement. Trichoscopy showed nonspecific signs suggestive of dissecting cellulitis, but histopathology revealed mucinous follicular destruction and a perifollicular lymphocytic infiltrate with immunophenotypic features of CTCL. Large-cell transformation was present in 10% of the infiltrate. Staging confirmed advanced FMF with secondary FM. Treatment with brentuximab vedotin achieved partial hair regrowth and skin improvement.Conclusion: This case describes an unusual presentation of FMF, in which diffuse alopecia with suppurative nodules was the first manifestation of secondary FM. Brentuximab vedotin may have a therapeutic role in mucinous alopecia in this context.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"118-123"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0