{"title":"Acantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.","authors":"Amal Chamli, Maryem Fazzeni, Imen Helal, Refka Frioui, Houda Hammami, Anissa Zaouak, Samy Fenniche","doi":"10.1159/000539465","DOIUrl":"10.1159/000539465","url":null,"abstract":"<p><strong>Introduction: </strong>Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.</p><p><strong>Case presentation: </strong>A 63-year-old female patient consulted for a longitudinal erythronychia (LE) associated with distal onycholysis. Dermoscopy showed LE with a few splinter hemorrhages, with localized hyperkeratosis and thinning of the nail plate at the free edge. Histopathology confirmed the diagnosis of ADA.</p><p><strong>Conclusion: </strong>ADA is a rare tumor that could mimic various inflammatory or neoplastic conditions. To our knowledge, this is the eighth reported case in the literature. This uncommon entity could mimic various inflammatory or neoplastic conditions.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 6","pages":"532-535"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaya L Curtis, Onajia Stubblefield, Shari R Lipner
{"title":"Alopecia Areata Is Associated with Posttraumatic Stress Disorder and Alcohol Use in a Case-Control Study of 4,785 Patients.","authors":"Kaya L Curtis, Onajia Stubblefield, Shari R Lipner","doi":"10.1159/000539424","DOIUrl":"10.1159/000539424","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have demonstrated association of alopecia areata (AA) with anxiety and depression. However, few case-control studies have evaluated AA association with posttraumatic stress disorder and lifestyle factors, including alcohol use. We aimed to assess associations of AA with psychiatric disorders and lifestyle factors using a national database.</p><p><strong>Methods: </strong>A nested case-control study using the National Institutes of Health <i>All of Us</i> database was conducted analyzing patients ≥18 years with AA diagnosis and controls matched 1:4 by age, sex at birth, and self-reported ethnicity/race.</p><p><strong>Results: </strong>There were 957 AA patients and 3,828 controls included in the final analysis. AA patients versus controls had higher odds of depression, posttraumatic stress disorder, anxiety, and alcohol use. AA patients had decreased odds of smoking.</p><p><strong>Conclusion: </strong>Our study demonstrates previously understudied AA associations with posttraumatic stress disorder, obesity, and alcohol use, and corroborates high burden of anxiety and depression among AA patients. We recommend screening AA patients for psychiatric disorders and alcohol use and appropriate referrals to psychiatry.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 6","pages":"520-523"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trichoscopy of Discoid Lupus Erythematosus in Caucasian Scalp: A Review.","authors":"Elisa Milan, Roberta Vezzoni, Michela V R Starace","doi":"10.1159/000539189","DOIUrl":"10.1159/000539189","url":null,"abstract":"<p><strong>Background: </strong>Scalp discoid lupus erythematosus in Caucasians is still a rare disease with a variable clinical presentation. Its dermoscopic characteristics are poorly described in literature, especially in the white population. The aim of this review was to critically analyze published papers on this topic and summarize relevant features.</p><p><strong>Summary: </strong>A comprehensive search for eligible articles was conducted in the databases of MEDLINE/PubMed. Results were analyzed following dermoscopic patterns such as follicular openings, hair shafts, perifollicular surface, and vessel pattern.</p><p><strong>Key messages: </strong>The most representative features appeared the absence of follicular openings and the presence of follicular keratotic plugs, along with yellow-brown and red dots. In long-lasting lesions with chronic stage, trichoscopy showed the absence of follicular openings, white or milky red cicatricial patches, white and brown structureless areas, and thick arborizing vessels.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 5","pages":"363-369"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michela Valeria Rita Starace, Aditya K Gupta, Mary A Bamimore, Mesbah Talukder, Federico Quadrelli, Bianca Maria Piraccini
{"title":"The Comparative Effects of Monotherapy with Topical Minoxidil, Oral Finasteride, and Topical Finasteride in Postmenopausal Women with Pattern Hair Loss: A Retrospective Cohort Study.","authors":"Michela Valeria Rita Starace, Aditya K Gupta, Mary A Bamimore, Mesbah Talukder, Federico Quadrelli, Bianca Maria Piraccini","doi":"10.1159/000538621","DOIUrl":"10.1159/000538621","url":null,"abstract":"<p><strong>Introduction: </strong>Oral finasteride and topical minoxidil are long-standing androgenetic alopecia (AGA) treatments; topical finasteride is a more recent medicine. Few studies have compared their therapeutic effects in postmenopausal women. We compared the therapeutic impact of topical finasteride (1-4 sprays of 0.25% topical finasteride solution daily for 12 months), oral finasteride (2.5 mg oral finasteride once daily for 12 months), and topical minoxidil (1 mL of topical minoxidil 5% twice daily for 12 months) in postmenopausal women with AGA.</p><p><strong>Methods: </strong>We conducted Bayesian network meta-analyses of individual patient-level data insofar as four clinically relevant endpoints, namely, 12-month change in (1) total hair density, (2) hair diameter, (3) clinical photographs, and (4) patients' opinion of efficacy. Data were obtained through medical charts. Regimens' surface under the cumulative ranking distribution (SUCRA) values and relative effects - as per odds ratios - were computed.</p><p><strong>Results: </strong>As per SUCRA, the most and least effective regimens - across the four outcomes - were oral finasteride, and topical finasteride, respectively; however, no significant statistical differences were found (i.e., <i>p ></i> 0.05).</p><p><strong>Conclusion: </strong>Oral finasteride is ranked more effective than the topical forms of minoxidil and finasteride; however, more studies are needed to confirm this result.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 4","pages":"293-300"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Update on Squamous Cell Carcinoma of the Nail Unit: An Human Papillomavirus-Associated Condition.","authors":"Eric R Bray, Antonella Tosti, Brian W Morrison","doi":"10.1159/000537760","DOIUrl":"10.1159/000537760","url":null,"abstract":"<p><strong>Background: </strong>Squamous cell carcinoma (SCC) and SCC in situ (Bowen's disease) are the most common malignancies of the nail unit. They are frequently seen in men over 50 and most commonly affect the fingers. The role of high-risk human papillomavirus (HPV) infection has been identified as a key contributor to the development of nail unit SCC.</p><p><strong>Summary: </strong>In this review, we aimed to summarize the current state of our understanding of how HPV contributes to nail unit SCC, the role of genitodigital transmission of HPV, and the clinical features of HPV-associated nail unit SCC. We also review current advances in the treatment of nail unit SCC, with a focus on the potential role of HPV vaccination in the treatment and prevention of nail unit SCC.</p><p><strong>Key messages: </strong>Nail unit SCC should be recognized as an HPV-associated disease. HPV vaccination may represent a non-surgical modality for the management of these challenging malignancies in the appropriate clinical setting.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"10 3","pages":"199-206"},"PeriodicalIF":1.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Growth Factors and Microneedling in Alopecia Areata: A Narrative Review","authors":"M. Almutlq, Abrar E. Bukhari","doi":"10.1159/000534636","DOIUrl":"https://doi.org/10.1159/000534636","url":null,"abstract":"Alopecia areata (AA) is an autoimmune condition that causes non-scarring hair loss on the scalp or other hair-bearing surfaces. Various signalling molecules regulate the hair cycle and hair follicle regeneration. These include genes, growth factors, nuclear receptors, cytokines, and subcellular signalling pathways. Growth factors can cause the vascular endothelium and dermal fibroblasts to proliferate, extend the anagen phase, and delay the initiation of catagen in the hair follicle, thereby promoting hair growth. Microneedling causes the release of growth factors and has been shown to help high-molecular-weight drugs penetrate the stratum corneum and hair follicles. These recent discoveries regarding the pathogenesis of AA have resulted in the development of promising therapies. Herein, this article reviews the use of growth factors and microneedling in the treatment of AA and explores their efficacy and safety. Treatment with growth factors and microneedling appears to be highly effective for AA, with no major adverse effects, and may provide a new option for hair regeneration therapy. To support the efficacy of growth factors and microneedling for AA treatment, additional large-scale studies of patients with AA are needed.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"33 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}