Skin Appendage Disorders最新文献

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Screening for Inflammatory Chronic Arthritis in Hidradenitis Suppurativa with Psoriatic Arthritis Uncluttered Screening Evaluation (PURE) Questionnaire. 化脓性汗腺炎伴银屑病关节炎的炎性慢性关节炎筛查(PURE)问卷调查。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-23 DOI: 10.1159/000547045
Patricia Garbayo-Salmons, Mireia Moreno, Albert Rodrigo-Parés, Ester Saus, Vicente Exposito-Serrano, Miquel Ribera, Joan Calvet
{"title":"Screening for Inflammatory Chronic Arthritis in Hidradenitis Suppurativa with Psoriatic Arthritis Uncluttered Screening Evaluation (PURE) Questionnaire.","authors":"Patricia Garbayo-Salmons, Mireia Moreno, Albert Rodrigo-Parés, Ester Saus, Vicente Exposito-Serrano, Miquel Ribera, Joan Calvet","doi":"10.1159/000547045","DOIUrl":"10.1159/000547045","url":null,"abstract":"<p><strong>Introduction: </strong>Considering the growing recognition of the association between hidradenitis suppurativa (HS) and spondyloarthritis, this study addresses a gap in clinical practice in HS consultation: the absence of a validated arthritis screening tool.</p><p><strong>Methods: </strong>Drawing on interdisciplinary collaboration between dermatology and rheumatology, we assayed a modified version of the PURE-4 tool: patient and dermatologist Psoriatic Arthritis Uncluttered Screening Evaluation-5 (p- and dPURE-5), adapted to reflect clinical features relevant to this population.</p><p><strong>Results: </strong>Of 214 HS patients, 125 (58.4%) were male, with a median age of 42 years (IQR 30-49). Buttock involvement was observed in 64 patients (29.9%) and was more common in males (35.7%) than in females (21.6%) (<i>p</i> = 0.26). Of the 214 patients, 82 (38.3%) answered negatively to all questions, while 118 (55.6%) answered positively to at least one question in the pPURE-5 but were later dismissed by the trained dermatologist after a more detailed interview. Finally, 14 patients (6.5%) were referred to Rheumatology due to a positive dPURE-5. Of these, 2 (14.3%) were diagnosed with inflammatory chronic arthritis, yielding a positive predictive value of 14.3%.</p><p><strong>Conclusion: </strong>To conclude, the PURE-5 questionnaire appeared valuable for guiding anamnesis and facilitating rheumatology referrals. Even so, there is still a need for new and validated screening tools for detecting arthritis in the HS population.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Spectrum of Phyma: A Case Report of Rhino-Metophyma and Review of the Literature. 鼻臭瘤的临床谱:鼻臭瘤1例报告及文献复习。
IF 1.3
Skin Appendage Disorders Pub Date : 2025-06-18 DOI: 10.1159/000546890
Ivano Luppino, Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali
{"title":"The Clinical Spectrum of Phyma: A Case Report of Rhino-Metophyma and Review of the Literature.","authors":"Ivano Luppino, Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali","doi":"10.1159/000546890","DOIUrl":"10.1159/000546890","url":null,"abstract":"<p><strong>Introduction: </strong>Phyma of the nose, or rhinophyma, is considered a diagnostic clinical phenotype of rosacea. Rarely, phyma manifestations may be present on the chin (gnathophyma), ear (otophyma), forehead (metophyma) and eyelids (blepharophyma). The purpose of this paper was to present a case of rhino-metophyma and to review the literature on the topic.</p><p><strong>Case presentation: </strong>A 74-year-old Caucasian male with a history of inflammatory rosacea, complained of marked nasal and frontal skin thickening. Based on clinical, ultrasound, and histopathological examination, the diagnosis of rhino-metophyma was formulated. A literature review from 2000 to 2024 revealed 14 cases of rhinophyma associated with other localizations: 7 cases of rhino-otophyma, 4 of rhino-gnathophyma, and 3 of rhino-metophyma. Reported cases of isolated extranasal phyma were 21: 10 of gnathophyma, 9 of otophyma, and 2 of metophyma. Overall, patients with involvement of the nose and extranasal phyma were predominantly males with a male:female ratio 6:1, while among extranasal localizations the male:female ratio was 1.1:1.</p><p><strong>Conclusion: </strong>The diagnosis of rhinophyma is clinical and in the majority of cases quite easy, less for the isolated phymas in extranasal localizations. Little is also known about the management of these forms, and more studies on the prevalence of extranasal localizations and their therapeutic management would be desirable.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Changes in Secondary Syphilis: A Report of 3 Cases and Review of Literature. 继发性梅毒甲改变3例报告并文献复习。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-11 DOI: 10.1159/000546719
Chander Grover, Sonia Agrawal, Aakash Singhal
{"title":"Nail Changes in Secondary Syphilis: A Report of 3 Cases and Review of Literature.","authors":"Chander Grover, Sonia Agrawal, Aakash Singhal","doi":"10.1159/000546719","DOIUrl":"10.1159/000546719","url":null,"abstract":"<p><strong>Introduction: </strong>Nail changes have been described in syphilis in all stages. However, they can be subtle and easy to miss. At the same time, they are valuable indicators towards underlying pathology as nail is a useful \"window to systemic disease.\" Onychoscopic features of nail syphilis have not been described in detail.</p><p><strong>Case report: </strong>We describe 3 patients (<i>n</i> = 60 nails) with secondary syphilis with involvement of 29/60 (48.3%) nails. Most common clinical nail findings were onychorrhexis (13, 37%), followed by distal onycholysis (10, 28%). Other findings included subungual hyperkeratosis, onychomadesis, Beau's lines, nail plate atrophy, paronychia, and periungual ulceration. Onychoscopic involvement was seen in 32/60 (53.3%) nails. Features observed on onychoscopy were onychorrhexis (13/60) and distal onycholysis (including erosive onycholysis) (12/60). Distinctive features on onychoscopy included alternate white and red lines, longitudinal erythematous bands, and ulcerative onycholysis.</p><p><strong>Conclusion: </strong>Nail involvement in syphilis, particularly the onychoscopic findings, has been under-reported. Varying terminologies have been used over the years as per the literature review. We propose that nail syphilis is best classified based on the site of involvement within the nail unit. Onychoscopy aids the detection of changes which may be missed on clinical examination.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Age on Response to Platelet-Rich Plasma Therapy. 年龄对富血小板血浆治疗反应的影响。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-11 DOI: 10.1159/000546800
Anna Brinks, Deesha D Desai, Caitlin A Kearney, Carli Needle, Nnaemeka Anyanwu, Ambika Nohria, Michelle Sikora, Christina S Oh, Jerry Shapiro, Kristen I Lo Sicco
{"title":"Impact of Age on Response to Platelet-Rich Plasma Therapy.","authors":"Anna Brinks, Deesha D Desai, Caitlin A Kearney, Carli Needle, Nnaemeka Anyanwu, Ambika Nohria, Michelle Sikora, Christina S Oh, Jerry Shapiro, Kristen I Lo Sicco","doi":"10.1159/000546800","DOIUrl":"10.1159/000546800","url":null,"abstract":"<p><strong>Introduction: </strong>Although platelet-rich plasma (PRP) is a widely used treatment for androgenetic alopecia (AGA), the impact of patient age on treatment efficacy remains underexplored.</p><p><strong>Method: </strong>This retrospective study evaluated PRP outcomes in 57 AGA patients treated at NYU Langone Health, stratified into four age cohorts. Changes in trichometric hair density and width were measured from initial to final follow-up visits. Statistical significance and linear regression testing were determined using ANOVA and Rank-Based ANCOVA, respectively.</p><p><strong>Results: </strong>While overall changes in density and width did not differ significantly across age groups, younger patients trended toward greater density gains. Furthermore, greater baseline hair width was predictive of smaller improvements in width, and significant interactions between age and the number of PRP sessions suggested that older individuals may require a greater number of treatments to attain results comparable to those seen in younger cohorts. Additionally, improvements in hair density were positively associated with the number of adjunctive therapies, as patients who received more concurrent treatments experienced greater gains. PRP was well tolerated across all age groups.</p><p><strong>Conclusion: </strong>These findings highlight the potential impact of patient age on PRP efficacy, informing counseling and treatment planning.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Associations of Central Centrifugal Cicatricial Alopecia: A Case-Control Study. 中心性离心性瘢痕性脱发的代谢关联:一项病例对照研究。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-04 DOI: 10.1159/000546799
Michael M Ong, Maggie H Zhou, Amit Singal, Shari R Lipner
{"title":"Metabolic Associations of Central Centrifugal Cicatricial Alopecia: A Case-Control Study.","authors":"Michael M Ong, Maggie H Zhou, Amit Singal, Shari R Lipner","doi":"10.1159/000546799","DOIUrl":"10.1159/000546799","url":null,"abstract":"<p><strong>Introduction: </strong>Central centrifugal cicatricial alopecia (CCCA) is a primary scarring alopecia with unclear etiology. Emerging evidence suggests an association with metabolic dysregulation, including altered protein levels in affected scalp tissue and increased insulin resistance. This study investigated potential associations between CCCA and metabolic dysfunction using a large, multicenter database.</p><p><strong>Method: </strong>Using the TriNetX database, we analyzed 2,482 black women with CCCA and 2,482 propensity score-matched controls with other primary scarring alopecias (2004-2024). Metabolic disorders and laboratory values were compared (Benjamini-Hochberg-adjusted <i>p</i> < 0.0042).</p><p><strong>Results: </strong>CCCA patients showed no differences in incidence of type 2 diabetes (19.7% vs. 19.5%, <i>p</i> = 0.591), prediabetes (17.8% vs. 21.0%, <i>p</i> = 0.265), obesity (30.9% vs. 38.5%, <i>p</i> = 0.054), or metabolic syndrome (1.4% vs. 1.2%, <i>p</i> = 0.404) compared to controls. CCCA patients had lower hypertension incidence (39.7% vs. 49.5%, <i>p</i> < 0.0001), higher HDL (58.0 vs. 55.5 mg/dL, <i>p</i> = 0.0016), and lower triglyceride (96.4 vs. 106.3 mg/dL, <i>p</i> = 0.0001) values.</p><p><strong>Conclusion: </strong>We found that CCCA was not associated with most metabolic disorders. Thus, metabolic screening in CCCA patients should be individualized based on history and review of systems. Future research exploring genetic, inflammatory, and autoimmune pathways in CCCA pathogenesis is needed.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences in Adverse Effects and Dosing Practices of Low-Dose Oral Minoxidil for Androgenetic Alopecia: A Retrospective Analysis of 310 Patients. 低剂量口服米诺地尔治疗雄激素性脱发的不良反应和给药方法的性别差异:310例回顾性分析。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-01 Epub Date: 2024-11-25 DOI: 10.1159/000542630
Michael M Ong, Huongly Do, Benedict Ho, Shari R Lipner
{"title":"Gender Differences in Adverse Effects and Dosing Practices of Low-Dose Oral Minoxidil for Androgenetic Alopecia: A Retrospective Analysis of 310 Patients.","authors":"Michael M Ong, Huongly Do, Benedict Ho, Shari R Lipner","doi":"10.1159/000542630","DOIUrl":"10.1159/000542630","url":null,"abstract":"<p><strong>Introduction: </strong>Off-label low-dose oral minoxidil (LDOM) is used for androgenetic alopecia (AGA) treatment, with limited safety data. We investigated LDOM adverse effects (AEs) in AGA patients.</p><p><strong>Methods: </strong>AGA patients taking LDOM were identified (January 1, 2010-December 3, 2022). AEs and management were recorded from follow-up and emergency room visits. Fisher's exact test, logistic regression, and Benjamini-Hochberg procedure assessed significance and adjusted for multiple comparisons.</p><p><strong>Results: </strong>Three hundred ten AGA patients were analyzed with mean age 47.5 years and 53.2% females. The average LDOM dose was lower for females vs. males. AEs were observed in 14.9% of patients, with dizziness/lightheadedness, hypertrichosis, and extremity edema being most common. Higher doses were associated with increased likelihood of dizziness/lightheadedness. Females had higher overall incidence of AEs; however, gender differences did not persist after subgroup analysis. Among patients experiencing AEs, 11.1% adjusted their dosage and 28.9% discontinued treatment.</p><p><strong>Conclusion: </strong>A higher LDOM dose increased risk of dizziness/lightheadedness in both genders, with females more likely to experience any AE. Patients are often started at inappropriately high doses, causing AE-induced regimen changes. Therefore, we recommend a cautious approach when prescribing LDOM, starting with lower doses and gradually increasing as tolerated, and counseling female patients regarding their higher risk of AEs.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"227-231"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Cross-Sectional Study of Hair Density and Hair Shaft Diameter of Different Severities of Anterior Scalp Marginal Traction Alopecia in Women. 不同严重程度女性头皮前缘牵引性脱发发密度和发干直径的横断面比较研究。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-01 Epub Date: 2024-12-19 DOI: 10.1159/000543221
Ehiaghe Lonia Anaba, Hadiza Sani
{"title":"A Comparative Cross-Sectional Study of Hair Density and Hair Shaft Diameter of Different Severities of Anterior Scalp Marginal Traction Alopecia in Women.","authors":"Ehiaghe Lonia Anaba, Hadiza Sani","doi":"10.1159/000543221","DOIUrl":"10.1159/000543221","url":null,"abstract":"<p><strong>Introduction: </strong>Hair density (HD) studies of marginal traction alopecia (MTA) are few. We aimed to document the HD/cm<sup>2</sup>, number of hair shafts (HS) per pilosebaceous unit (PU), and HS diameter of different grades of anterior scalp margin MTA (AMTA).</p><p><strong>Methods: </strong>A cross-sectional descriptive study of 401 women over a 9-month period in 2023. The severity of AMTA was scored using the marginal traction alopecia severity score. Phototrichoscopic evaluation of HD/cm<sup>2</sup>, HS diameter, and number of HS per PU was done on the alopecic intertemporal, right and left temporal, and the non-alopecic right temporal and intertemporal scalp sites.</p><p><strong>Results: </strong>The HD/cm<sup>2</sup> of the non-alopecic intertemporal scalp site ranged from 282 to 519 cm<sup>2</sup> compared to that of the AMTA which ranged from 14 to 349/cm<sup>2</sup>, <i>p</i> < 0.001. With increasing severity of AMTA, there was a significant decrease in HD: grade 1 had HD of 227.56/cm<sup>2</sup> compared to 131.22/cm<sup>2</sup> in grade 4 at the intertemporal area, <i>p</i> < 0.001. HS diameter ranged from 0.0087 to 0.0200 mm in grade 1 and 0.0078-0.0100 in grade 4. Single hair units were present in 100%.</p><p><strong>Conclusion: </strong>Anterior scalp marginal alopecia results in a significant reduction of HD, hair shaft diameter, and number of hair strands. Preventative education on hair care practices and hair styles is advocated.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"207-214"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subungual Eccrine Poroma: An Unusual Location. 趾甲下内分泌斑疹:一个不寻常的位置。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-01 Epub Date: 2025-01-13 DOI: 10.1159/000543514
Pratibha Gupta, Athota Kavitha, Chander Grover
{"title":"Subungual Eccrine Poroma: An Unusual Location.","authors":"Pratibha Gupta, Athota Kavitha, Chander Grover","doi":"10.1159/000543514","DOIUrl":"10.1159/000543514","url":null,"abstract":"<p><strong>Introduction: </strong>Eccrine poroma is a rare benign adnexal tumor that originates from the acrosyringium of eccrine sweat ducts, typically found on palms and soles. Its occurrence in subungual location is rare, making diagnosis and treatment challenging. We present the details of subungual eccrine poroma, emphasizing its unusual presentation, dermoscopic features, and management.</p><p><strong>Case presentation: </strong>A 36-year-old female presented with a slowly growing, asymptomatic, reddish subungual mass under the left index finger nail for the past 5 years. Onychoscopy showed a reddish-pink homogenous area with keratotic borders, reddish globules, and dotted vessels. An excisional biopsy was done, and a final diagnosis of eccrine poroma was made on histopathology, with no recurrence over 6 months of follow-up.</p><p><strong>Conclusion: </strong>Given the rarity of subungual involvement, our case highlights the importance of considering eccrine poroma in the differential diagnosis of subungual tumors. Onychoscopy can aid in diagnosis and differentiation from other subungual masses, though a definitive diagnosis requires histopathology.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"302-306"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curved Melanonychia as a Diagnostic Clue for Subungual Pigmented Squamous Cell Carcinoma in situ. 弯曲的黑马甲作为甲下原位色素鳞状细胞癌的诊断线索。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-01 Epub Date: 2024-11-09 DOI: 10.1159/000542546
Michelle Gatica-Torres, Samantha Paola Bermúdez-Rodríguez, Judith G Domínguez-Cherit
{"title":"Curved Melanonychia as a Diagnostic Clue for Subungual Pigmented Squamous Cell Carcinoma in situ.","authors":"Michelle Gatica-Torres, Samantha Paola Bermúdez-Rodríguez, Judith G Domínguez-Cherit","doi":"10.1159/000542546","DOIUrl":"10.1159/000542546","url":null,"abstract":"","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"307-308"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Non-Prescription Products Help in Managing Androgenic Alopecia? 非处方产品有助于治疗雄激素性脱发吗?
IF 1.4
Skin Appendage Disorders Pub Date : 2025-06-01 Epub Date: 2024-12-06 DOI: 10.1159/000542880
Aditya K Gupta, Honglin Wang, Tong Wang, Mesbah Talukder
{"title":"Do Non-Prescription Products Help in Managing Androgenic Alopecia?","authors":"Aditya K Gupta, Honglin Wang, Tong Wang, Mesbah Talukder","doi":"10.1159/000542880","DOIUrl":"10.1159/000542880","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is the most common cause of hair loss. Currently, approved medications for AGA are topical minoxidil and oral finasteride, both of which are prescription medications which may cause side effects. Non-prescription products such as herbal extracts and over-the-counter medications have limited evidence regarding safety and efficacy; however, they may be an alternative for patients unable or unwilling to use prescription medication.</p><p><strong>Summary: </strong>This article reviews investigator-blinded, controlled clinical trials assessing the efficacy of non-prescription monotherapies in treating AGA. A total of 13 studies were included using procyanidin, cetirizine, caffeine, <i>Oryza sativa</i> bran, pumpkin seed oil, rosemary oil, saw palmetto, and watercress. The available data demonstrate considerable improvements in one or more parameters: total hair density, terminal hair density and hair diameter. Procyanidin and cetirizine were investigated in more investigator-blinded, randomized controlled trials than other agents. Minimal adverse events were observed; however, more robust clinical trial and long-term safety and efficacy data are warranted.</p><p><strong>Key message: </strong>Additional investigations through the conduct of high quality randomized, controlled trials with larger numbers of patients will help determine the effectiveness and safety of this class of compounds, either as monotherapy or as an addition to current pharmacological interventions.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"270-281"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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