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Skin Appendage Disorders最新文献

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Onychocytic Matricoma Presenting as Longitudinal Melanonychia in a Skin of Color Patient. 一名有色人种患者身上出现纵向黑色素瘤的绒毛膜母细胞瘤
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-06-02 DOI: 10.1159/000530470
Gabriella Alvarez, Connie Kha, M Angelica Selim, Amber Fresco
{"title":"Onychocytic Matricoma Presenting as Longitudinal Melanonychia in a Skin of Color Patient.","authors":"Gabriella Alvarez, Connie Kha, M Angelica Selim, Amber Fresco","doi":"10.1159/000530470","DOIUrl":"10.1159/000530470","url":null,"abstract":"<p><strong>Introduction: </strong>Onychocytic matricoma (OCM) is a benign acanthoma of the nail matrix that presents with longitudinal melanonychia and nail thickening. Only 18 previously reported cases of OCM are in the literature since it was first described in 2012.</p><p><strong>Case presentation: </strong>The purpose of this case report was to report a unique presentation of OCM in the toenail of a Black patient as well as to review the clinical presentation, histologic features, and management of this rare entity. Previously described cases presented on the fingernails and were predominantly in white males.</p><p><strong>Conclusion: </strong>OCM is a benign entity that may mimic a nail unit melanoma or squamous cell carcinoma especially when pachyonychia is present. Despite some clinical clues to suggest a diagnosis of OCM, a nail matrix biopsy is often required to rule out malignancy.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"296-299"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Ultrasound with Magnetic Resonance Imaging in the Evaluation of Subungual Glomus Tumors and Subungual Myxoid Cysts. 比较超声与磁共振成像在评估舌下结节瘤和舌下肌样囊肿中的应用
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-05-26 DOI: 10.1159/000530397
Alysha Dhami, S Max Vale, Michael L Richardson, April K Schachtel, Philip Fleckman
{"title":"Comparing Ultrasound with Magnetic Resonance Imaging in the Evaluation of Subungual Glomus Tumors and Subungual Myxoid Cysts.","authors":"Alysha Dhami, S Max Vale, Michael L Richardson, April K Schachtel, Philip Fleckman","doi":"10.1159/000530397","DOIUrl":"10.1159/000530397","url":null,"abstract":"<p><strong>Introduction: </strong>Subungual myxoid cysts and subungual glomus tumors demonstrate characteristic features on magnetic resonance imaging (MRI) and ultrasound (US). It is not yet well-established whether US is congruent to MRI in diagnostic evaluation of these subungual lesions.</p><p><strong>Methods: </strong>Participants with clinical suspicion for subungual glomus tumors or subungual myxoid cysts were recruited. After clinical evaluation, participants underwent radiography, MRI, and US plus biopsy, aspiration, or excision where possible. Differential diagnoses were revised after review of imaging, and imaging findings were compared to definitive diagnosis by pathology, aspiration, or clinical course.</p><p><strong>Results: </strong>All lesions were visible on both US and MRI and size estimates agreed between the two modalities. US and MRI findings of subungual glomus tumors and subungual myxoid cysts agreed with their known respective imaging characteristics.</p><p><strong>Conclusions: </strong>Diagnosis of subungual myxoid cysts and subungual glomus tumors agreed between US and MRI. We provide sample MRI and US imaging parameters for optimal evaluation of subungual myxoid cysts and glomus tumors. We demonstrate that subungual MRI evaluation can be performed without special equipment, allowing for evaluation by most radiology departments. Lastly, US is user-dependent and may be non-inferior for a sonographer familiar with subungual US.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"262-267"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigmented Desmoplastic Trichilemmoma Arising in Nevus Sebaceous: A Potential Mimicker of Pigmented Basal Cell Carcinoma. 皮脂腺痣中出现的色素脱鳞屑性三毛瘤：色素性基底细胞癌的潜在模仿者
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-13 DOI: 10.1159/000530001
Meshal M Alhameedy, Omar A Alrobaish, Sulaiman Almarshoud, Rand Albahli
{"title":"Pigmented Desmoplastic Trichilemmoma Arising in Nevus Sebaceous: A Potential Mimicker of Pigmented Basal Cell Carcinoma.","authors":"Meshal M Alhameedy, Omar A Alrobaish, Sulaiman Almarshoud, Rand Albahli","doi":"10.1159/000530001","DOIUrl":"10.1159/000530001","url":null,"abstract":"<p><strong>Introduction: </strong>Trichilemmomas are a form of benign adnexal neoplasm with differentiation toward the follicular outer sheath. Nevus sebaceous (NS) of Jadassohn is a congenital malformation characterized as a nonhereditary hamartoma of the adnexal structures of the skin, mainly the pilosebaceous unit. NS represents a fertile field for the development of secondary adnexal neoplasms, commonly benign but occasionally malignant. To our knowledge, one case of a pigmented desmoplastic trichilemmoma (DT) has been reported in the English literature.</p><p><strong>Case presentation: </strong>We report a case of a 36-year-old male with pigmented DT that developed on long-standing congenital NS, mimicking pigmented basal cell carcinoma (BCC), which was successfully excised with 4-mm margins.</p><p><strong>Conclusion: </strong>Pigmented DT may mimic pigmented BCC on clinical and dermatoscopic examination; therefore, histological evaluation is always recommended to confirm the diagnosis.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"309-312"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature. 指甲鳞状细胞癌伴有瘤状特征：病例报告和文献综述。
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-14 DOI: 10.1159/000529906
Kelita Waterton, Cynthia M Magro, Shari R Lipner
{"title":"Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature.","authors":"Kelita Waterton, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000529906","DOIUrl":"10.1159/000529906","url":null,"abstract":"<p><strong>Introduction: </strong>Onycholemmal carcinoma (OC) is a rare subtype of squamous cell carcinoma (SCC) that originates from the epithelium of the nail bed. It is characterized by distinct histopathologic features including small clusters of atypical squamous epithelium devoid of a granular layer, with abrupt onycholemmal keratinization.</p><p><strong>Case presentation: </strong>We present a case of a 75-year-old male with right thumbnail onycholysis, yellow-green nail plate discoloration, as well as bleeding and purulence of the lateral nail fold. Histopathologic evaluation revealed high-grade squamous dysplasia, small clusters of severely atypical epithelial cells, and a pattern of abrupt keratinization consistent with the diagnosis of SCC carcinoma with onycholemmal features. GMS and PAS staining indicated concomitant onychomycosis. Pathologic analysis also disclosed residual SCC and concomitant amyloidosis, possibly light chain related and hence reflective of his underlying multi-organ lymphoplasmacytic lymphoma. The patient subsequently underwent Mohs micrographic surgery.</p><p><strong>Conclusion: </strong>Clinical presentation of nail unit SCC with onycholemmal features is highly variable, making differentiating between similarly presenting benign and malignant nail disorders particularly challenging. This case report demonstrates clinical and histopathological features of nail unit SCC with onycholemmal features to improve diagnosis and management.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"284-290"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on Chemical Peels for Nail Surface Rejuvenation. 化学换肤用于指甲表面年轻化的综述。
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-06-08 DOI: 10.1159/000530629
Wilhelmina Lam, Antonella Tosti
{"title":"Review on Chemical Peels for Nail Surface Rejuvenation.","authors":"Wilhelmina Lam, Antonella Tosti","doi":"10.1159/000530629","DOIUrl":"10.1159/000530629","url":null,"abstract":"<p><strong>Introduction: </strong>Superficial nail plate abnormalities are a potential consequence of harsh cosmetic manicures and also manifest as a symptom of nail diseases such as nail lichen planus, nail psoriasis, and onychomycosis. Chemical peels for the nails may provide a solution to improve nail appearance. We reviewed articles that assessed the efficacy of using chemical peels for the nails.</p><p><strong>Methods: </strong>Searches on PubMed were performed to identify studies that discussed the use of chemical peels on the nail published up to July 2022.</p><p><strong>Results: </strong>A total of 4 studies with a total of 96 patients were found involving the use of chemical peels for the nail. It was found that there was marked improvement in aesthetic appearance for nail surface abnormalities induced by cosmetics.</p><p><strong>Discussion/conclusion: </strong>Studies with larger sample sizes that compare the efficacy of doses, treatment length, and a standardized method to assess results are needed to determine best treatment protocol. Chemical peels for the nails may provide fast improvement of the appearance of the nail and be utilized as a supportive treatment in association with specific treatment.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"237-240"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9979014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program. 侏儒症与皮肤病和血管病有关：我们所有人研究计划的病例对照研究。
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-20 DOI: 10.1159/000530096
Zi-Ning Choo, Shari R Lipner
{"title":"Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program.","authors":"Zi-Ning Choo, Shari R Lipner","doi":"10.1159/000530096","DOIUrl":"10.1159/000530096","url":null,"abstract":"<p><strong>Introduction: </strong>Onychogryphosis is a nail condition characterized clinically by a thickened, curved, yellow-brown, and opaque nail plate and may result in pain, paronychia, and onychogryphosis.</p><p><strong>Methods: </strong>We performed a nested case-control study of 1,114 onychogryphosis patients and 3,423 matched controls to quantify the association between onychogryphosis and self-care limitations, chronic foot injury, dermatologic conditions, and vascular disease.</p><p><strong>Results and conclusion: </strong>Onychogryphosis was positively associated with increased age, activity limitations (difficulty running errands alone, bathing, and concentrating), psoriasis, onychomycosis, hallux malleus, hallux valgus, peripheral vascular disease, lower extremity ulcers, venous varices, and type II diabetes mellitus. Therefore, physicians should screen patients presenting with onychogryphosis for these conditions.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"252-257"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit. 指甲部位盘状红斑狼疮引发的鳞状细胞癌
IF 1
Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-15 DOI: 10.1159/000529360
Tatiana Mina Yendo, Tatiana Villas Boas Gabbi, Marcello Menta Simonsen Nico
{"title":"Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit.","authors":"Tatiana Mina Yendo, Tatiana Villas Boas Gabbi, Marcello Menta Simonsen Nico","doi":"10.1159/000529360","DOIUrl":"10.1159/000529360","url":null,"abstract":"<p><strong>Introduction: </strong>Discoid lupus erythematosus can affect periungual tissues leading to onychodystrophy. Squamous cell carcinoma can occur in persistent scars of discoid lupus; this rare occurrence has not yet been reported on the nail unit. Case presentation: we report a case of squamous cell carcinoma occurring on the distal phalanx of the thumb in a patient with longstanding periungual discoid lupus on several fingernails.</p><p><strong>Discussion: </strong>Periungual discoid lupus erythematosus is rare. The scars caused by this disease can very rarely develop into squamous cell carcinoma. This is the first report of this occurrence at the periungual tissues.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"221-223"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa. 血清淀粉样蛋白 A：化脓性扁平湿疹严重程度的潜在新标志物
IF 1.4
Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-20 DOI: 10.1159/000528658
Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
{"title":"Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa.","authors":"Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1159/000528658","DOIUrl":"10.1159/000528658","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.</p><p><strong>Methods: </strong>Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.</p><p><strong>Results: </strong>SAA levels were significantly associated with number of nodules (<i>p</i> = 0.005), abscesses (<i>p</i> < 0.001), fistulas (<i>p</i> = 0.016), and severe IHS4 (<i>p</i> = 0.088 and <i>r</i> = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.</p><p><strong>Conclusions: </strong>We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"165-168"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Series of Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution: Is There a Familial Correlation? 额部纤维性脱发和花纹分布的纤维性脱发病例系列：是否存在家族相关性？
IF 1
Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-30 DOI: 10.1159/000529923
Maria Fernanda Reis Gavazzoni Dias, Amanda Lofeu Cury, Enoi Aparecida Guedes Vilar, Patricia Guimarães Peixoto, Chloe Ekelem
{"title":"Case Series of Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution: Is There a Familial Correlation?","authors":"Maria Fernanda Reis Gavazzoni Dias, Amanda Lofeu Cury, Enoi Aparecida Guedes Vilar, Patricia Guimarães Peixoto, Chloe Ekelem","doi":"10.1159/000529923","DOIUrl":"10.1159/000529923","url":null,"abstract":"<p><strong>Introduction: </strong>Frontal Fibrosing Alopecia (FFA) and Fibrosing Alopecia in a Pattern Distribution (FAPD) are two distinct entities of cicatricial pattern hair loss that share histological features of perifollicular lichenoid inflammation associated with concentric fibrosis. Although the pathophysiology of FFA and FAPD are still unknown, recently published reports of familial cases indicate a possible genetic correlation.</p><p><strong>Case presentation: </strong>We report 6 cases of familial alopecia composed of mothers and daughters: five with FFA and one with FAPD. We describe clinical, trichoscopy and histological correlation in cases of familial alopecia.</p><p><strong>Conclusions: </strong>These cases of mother and daughter disease association suggest a potential benefit of and role for performing systematic scalp examinations of all first-degree relatives of patients with pattern cicatricial alopecia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"230-234"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features. 阿达木单抗诱发的银屑病性脱发和矛盾性银屑病可使用赛妥珠单抗成功治疗：临床、三镜和体内反射共聚焦显微镜特征。
IF 1
Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2022-12-08 DOI: 10.1159/000527985
Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza
{"title":"Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features.","authors":"Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza","doi":"10.1159/000527985","DOIUrl":"10.1159/000527985","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriatic alopecia is considered a type of hair loss occurring in patients with psoriasis. Adalimumab is a fully humanized recombinant anti-TNF-alpha monoclonal antibody approved for treatment of psoriasis and psoriatic arthritis (PsA), rarely related to the occurrence of dermatological disorders.</p><p><strong>Case presentation: </strong>We report the case of a 56-year-old female with PsA developing psoriatic alopecia and paradoxical psoriasis induced by adalimumab and successfully treated switching to certolizumab, evaluating response at both thrichoscopy and in vivo reflectance confocal microscopy.</p><p><strong>Discussion: </strong>Among anti-TNF-α agents, certolizumab is the least involved in the development of paradoxical reactions such as psoriatic alopecia and showed to be an effective and safe alternative therapeutic options to manage psoriasis and PsA minimizing the risk of paradoxical reactions.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"207-210"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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