Skin Appendage Disorders最新文献

{"title":"Assessing Patient's Values When Selecting Treatments for Alopecia Areata: A Cross-Sectional Survey Study.","authors":"Lara Drake, Jane Han, Sophia Reyes-Hadsall, Arash Mostaghimi, Kathie Huang","doi":"10.1159/000527251","DOIUrl":"10.1159/000527251","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an autoimmune condition that results in nonscarring hair loss. There is currently only one Food and Drug Administration (FDA)-approved treatment for AA; as a result, a wide range of treatments are commonly administered. This study aimed to determine how patients with AA prioritize treatment characteristics when choosing a therapy.</p><p><strong>Methods: </strong>A cross-sectional national survey was distributed using the National Alopecia Areata Foundation's (NAAF) email list. This study was approved by the Mass General Brigham Institutional Review Board. Participants were asked to rank the importance of five treatment domains.</p><p><strong>Results: </strong>Of the 1,074 completed surveys (completion rate 77.4%), most respondents were female (85.4%) and white (77.8%) with an average age of 49.3 ± 15.4 years. Respondents had AA for an average of 17.7 ± 15.4 years, with 90.0% experiencing current active hair loss. 95.6% of respondents considered the treatment's ability to achieve hair regrowth as important, 93.9% listed the availability of information about the treatment (e.g., via doctor or online) as important, 89.1% ranked the treatment side effects as important, 75.7% the cost, and 68.0% the convenience of use. A sub-analysis was performed examining responses between respondents who identify as white versus nonwhite, which showed that while the order of importance was the same between groups, a significantly larger proportion of nonwhite respondents attributed higher importance to cost (white: 73.8%, nonwhite: 82.4%; <i>p</i> = 0.006) and convenience (white: 65.3%, nonwhite: 77.3%; <i>p</i> < 0.001) than their white counterparts.</p><p><strong>Discussion/conclusion: </strong>These findings identify key domains that can serve as a starting point in shared decision-making between patients and physicians. This knowledge can streamline dermatologist delivery of key information and highlight areas of improvement for future therapeutics. Limitations include the nonrandomized NAAF population with most participants being white females. Future studies should confirm these findings in other patient populations.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"99-103"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Disorders in Autoimmune Diseases.","authors":"Giselle Rodríguez-Tamez, Maira Elizabeth Herz-Ruelas, Minerva Gómez-Flores, Jorge Ocampo-Candiani, Sonia Chavez-Alvarez","doi":"10.1159/000527933","DOIUrl":"10.1159/000527933","url":null,"abstract":"<p><p>Alopecia is a common feature in several autoimmune diseases. With a wide spectrum of clinical presentations, it may manifest with a scarring or non-scarring nature, in a diffuse, patchy, or localized pattern. We as dermatologists have the opportunity of assessing patients with hair loss who may have an underlying undiagnosed autoimmune disorder. This review aimed to describe the main clinical, trichoscopic, and histopathological features of hair disorders associated with autoimmune diseases.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"84-93"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cutaneous Hamartomatous Adnexal Tumor: Trichofolliculoma.","authors":"Emre Zekey, Gülcan Saylam Kurtipek","doi":"10.1159/000527981","DOIUrl":"10.1159/000527981","url":null,"abstract":"<p><strong>Introduction: </strong>Trichofolliculoma is a very rare, benign hamartomatous skin adnexal tumor originating from the hair follicle. The tumor which presents as a papule or nodule is usually observed on the scalp and face.</p><p><strong>Case presentation: </strong>We report the case of a 49-year-old female who presented with a solitary papule on the nose. The lesion which was observed macroscopically and dermoscopically compatible with trichofolliculoma was completely removed by punch biopsy. The diagnosis of trichofolliculoma was confirmed histopathologically, and no recurrence was observed in the follow-up.</p><p><strong>Conclusion: </strong>Trichofolliculomas can macroscopically mimic some skin cancers such as basal cell carcinoma and sebaceous carcinoma. Awareness of its typical clinical and dermoscopic features facilitates diagnosis and prevents aggressive surgical intervention.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"121-125"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Rates of Psychosocial Screening and Lifestyle Counseling in Hidradenitis Suppurativa Patients in the USA.","authors":"Terri Shih, Devea R De, Jonathan Rick, Vivian Y Shi, Jennifer L Hsiao","doi":"10.1159/000528253","DOIUrl":"10.1159/000528253","url":null,"abstract":"<p><strong>Introduction: </strong>Although hidradenitis suppurativa (HS) is associated with psychosocial comorbidities such as depression as well as modifiable comorbidities such as obesity, rates of psychosocial screening and lifestyle counseling in the USA have not been characterized.</p><p><strong>Methods: </strong>This cross-sectional study utilized publicly available data from the National Ambulatory Medical Care Survey (NAMCS) between 2008 and 2018 to identify visits with a diagnosis of HS (ICD-9 code 705.83, ICD-10 code L73.2). <i>T</i> tests and multivariate logistic regressions analyzed trends in rates of screening and counseling while controlling for race, sex, and age. Survey weights are applied to each visit to represent a national sample.</p><p><strong>Results: </strong>Depression screening was completed in only 2% of reported visits. No visits reported screening for alcohol misuse, substance abuse, or domestic violence. There were low rates of counseling for weight reduction (7.8%), diet and nutrition (3.3%), exercise (2.4%), smoking (1.0%), and substance abuse (0.7%). Black patients and individuals with public health insurance received less screening and counseling overall.</p><p><strong>Conclusion: </strong>Rates of psychosocial screening and counseling on lifestyle modifications are low in ambulatory clinic visits for HS patients, and there are disparities based on race and insurance status. Implementing strategies to incorporate routine psychosocial screening and lifestyle counseling into visits may improve HS patient outcomes.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"94-98"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β₁ in Patients with Alopecia Areata.","authors":"Noha Mohamad, Ahmed M B Khedr, Olfat Gamil Shaker, Mohammed Hassan","doi":"10.1159/000527851","DOIUrl":"10.1159/000527851","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is a common autoimmune condition that affects anagen hair follicles. The most commonly recognized theory is that it is a T-cell-mediated autoimmune disorder in a genetically susceptible individual. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were thought to play a function in the pathogenesis. The expression of lncRNA HOTAIR and miRNA-205 and their relation to transforming growth factor β1 (TGF-β1) in AA were not studied.</p><p><strong>Aim: </strong>The aim of the studywas to evaluate the role of miRNA-205, lncRNA, HOTAIR, and TGF-β1 levels in AA pathogenesis, clinical course, and severity of AA.</p><p><strong>Methods: </strong>Two groups of subjects were included in this case-control study: 50 patients with AA and 50 healthy matched controls. miRNA-205 and lncRNA HOTAIR expression levels were assayed using quantitative RT-PCR, while serum levels of TGF-β1 were assayed using ELISA techniques.</p><p><strong>Results: </strong>The serum expression of lncRNA HOTAIR was significantly downregulated in AA patients with a <i>p</i> value < 0.001, while the serum expression of both miRNA-205 and TGF-β1 were significantly upregulated in patients.</p><p><strong>Discussion/conclusion: </strong>This study highlights the potential role of high serum expression of miRNA-205 and TGF-β1 and the low serum expression of lncRNA HOTAIR in AA pathogenesis. This could be used as a therapeutic target to treat AA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"111-120"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activated Platelet Rich Plasma versus Non-Activated Platelet Rich Plasma in the Treatment of Alopecia Areata.","authors":"Ahmed Hassan Nouh, Ahmed Mohamed Abdelaal, Ali El Sayed Fathy","doi":"10.1159/000526765","DOIUrl":"10.1159/000526765","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata is a common recurrent T cell-mediated autoimmune-induced non-scarring hair loss with not fully understood pathogenesis. It affects nearly 2% of the general population during lifetime. The course of the disease is unpredictable, and currently no treatment is available for complete cure or prevention. Platelet rich plasma (PRP) is an autologous blood-derived product, which has widely spread in the last decades for treatment of different dermatological conditions including hair disorders.</p><p><strong>Methods: </strong>The aim of this work was to evaluate the efficacy and safety of activated PRP in comparison to non-activated PRP in the treatment of alopecia areata. This study was conducted on two groups of 20 subjects each who received 4 treatments of intradermal injection of activated and non-activated PRP.</p><p><strong>Results and conclusion: </strong>Data obtained in our research confirm that PRP is safe, effective, and well tolerated by patients as a treatment modality for alopecia areata. Besides, such a method is cost-effective as there is no need for any expensive tools for preparation and it can be done in outpatient clinics. Also, activation of PRP prior to injection is not mandatory as there was no statistically significant difference between both groups.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 1","pages":"42-49"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail Changes during Pregnancy: A Cross-Sectional Survey of Patients at an Academic Center.","authors":"Justin Matushansky, Yu Wang, Michelle J Chang, Charlene Thomas, Steven Hockstein, Shari R Lipner","doi":"10.1159/000526870","DOIUrl":"10.1159/000526870","url":null,"abstract":"<p><strong>Introduction: </strong>Physiological changes in skin and hair are common during pregnancy. There are limited data on nail changes during pregnancy. Therefore, our study objectives were to determine prevalence and types of nail changes in pregnant women.</p><p><strong>Methods: </strong>A prospective study was conducted in the Weill Cornell Obstetrics and Gynecology waiting room, where a 32-question survey was administered to pregnant and nonpregnant patients.</p><p><strong>Results: </strong>There was a total of 167 subjects (73 pregnant, 94 nonpregnant). Nail changes were reported by 25/73 (34.2%) and 12/94 (12.8%) pregnant and nonpregnant women, respectively (<i>p</i> < 0.05). Onychocryptosis and leukonychia were more common in pregnant (12.3% and 13.7%, respectively) versus nonpregnant women (5.3% and 0%, respectively) (<i>p</i> < 0.05). The majority of patients reported no changes in nail growth, thickness, brittleness, during their pregnancies.</p><p><strong>Discussion/conclusion: </strong>Most nail changes in pregnant and nonpregnant women are similar. Physicians should educate women that onychocryptosis and leukonychia are common and benign findings during pregnancy.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 1","pages":"27-29"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice Dilemma: Expanding Melanonychia in the Paediatric Setting.","authors":"Cheng Huang, Peter Bullpitt, Mark Nabarrro, Dedee Frances Murrell","doi":"10.1159/000526102","DOIUrl":"10.1159/000526102","url":null,"abstract":"<p><strong>Introduction: </strong>Differentiating between benign and malignant pathology in melanonychia can be challenging, particularly in paediatric patients as nail biopsies often require general anaesthesia.</p><p><strong>Case presentation: </strong>An 11-year-old healthy Vietnamese female presented with a pigmented right third fingernail. It was first noticed at age 1 and had gradually involved the whole nail plate by age 4. On examination, Hutchinson's sign was thought to be positive. Dermatoscopy revealed a variation of colours and spacing of the pigmentation. Due to the concerning clinical findings, nail removal was performed. Histology of the nail matrix squamous epithelium showed prominent melanin pigmentation. Both SOX10 and Melan A stain showed an increase in the melanocytes within the nail bed epithelium. There was no confluence of melanocytes or melanocytic nests within the nail matrix epithelium. Overall, a benign process (lentigo with melanocyte hyperplasia) was favoured given the young age of the patient, lack of cell atypia, lack of confluence or expansile growth, and a lack of significant pagetoid spread of the melanocytes.</p><p><strong>Conclusion: </strong>Ascertaining the cause of melanoychia can be challenging, and histology may not clearly differentiate between benign and malignant causes. Careful clinical evaluation and detailed discussion with the patient and family should be thoroughly undertaken in those cases.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 1","pages":"58-60"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Rationale for the Use of an Alpha-Melanocyte-Stimulating Hormone Analog to Improve Gray Hair Repigmentation?","authors":"Daniel Fernandes Melo, Sandra Tagliolatto, Ana Cecília Studart, Bruna Fanton Gallo, Carla Jorge Machado, Simone Carolina Frattini, Flavia Weffort, Rita Fernanda Cortez de Almeida","doi":"10.1159/000527605","DOIUrl":"10.1159/000527605","url":null,"abstract":"","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 1","pages":"50-53"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seborrheic Dermatitis as a Potential Trigger of Central Centrifugal Cicatricial Alopecia: A Review of Literature.","authors":"Nwanneka Okwundu, Chiagoziem Ogbonna, Amy J McMichael","doi":"10.1159/000526216","DOIUrl":"10.1159/000526216","url":null,"abstract":"<p><p>Central centrifugal cicatricial alopecia (CCCA) is a common form of scarring alopecia that affects the crown or vertex of the scalp as centrifugally spreading patches of permanent hair loss. The etiology of CCCA is uncertain. Genetic predisposition, autoimmune diseases, infections (bacterial and fungal), and other idiopathic factors have all been explored as potential risk factors for the development of CCCA. Seborrheic dermatitis (SD) has been identified in a number of studies as the most common concurrent hair disorder seen in patients with CCCA. The high prevalence of SD in African American women and its association with long-term inflammation of the scalp may increase the likelihood of a connection between SD and other inflammatory conditions of the scalp in this population. Since it has frequently been discovered as a concomitant diagnosis in patients with CCCA, we hypothesize that a history of SD may play a role in the pathogenesis of CCCA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 1","pages":"13-17"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}