Colin Michael Kincaid, Nadine Ben Romdhane, Ella A Csuka, Ajay Nair Sharma, Margit Juhasz, Natasha Atanaskova Mesinkovska
{"title":"Is There a Role for Radiofrequency Devices in Hair?","authors":"Colin Michael Kincaid, Nadine Ben Romdhane, Ella A Csuka, Ajay Nair Sharma, Margit Juhasz, Natasha Atanaskova Mesinkovska","doi":"10.1159/000528848","DOIUrl":"10.1159/000528848","url":null,"abstract":"<p><strong>Background: </strong>Radiofrequency (RF) devices are being increasingly used for cosmetic dermatology applications. Recent studies have reported an apparent dualistic nature of RF devices for hair, causing either removal or growth depending on the modality of RF.</p><p><strong>Materials and methods: </strong>PubMed/MEDLINE and Web of Science searches were conducted in July 2022 according to PRISMA guidelines for studies discussing RF technology in hair applications (<i>n</i> = 19).</p><p><strong>Results: </strong>The majority of studies describe the utility of RF devices in removal of unwanted hair (<i>n</i> = 15). Bipolar RF has been used in combination with intense pulsed light for effective long-term removal of body and facial hair. The chromophore-independent method of energy delivery in RF makes it a viable add-on therapy for treating lighter colored hair and darker Fitzpatrick skin types. Monopolar RF is used for eyelash removal in patients with trichiasis. In contrast, fractional RF has been used to stimulate hair growth in patients with alopecia areata and androgenetic alopecia.</p><p><strong>Conclusions: </strong>Preliminary evidence supports the use of bipolar and monopolar RF devices for hair removal, while fractional RF appears to be an emerging technology for hair growth. Additional studies are needed to investigate the efficacy, mechanisms, and parameters of radiofrequency devices for various hair applications.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"169-178"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pernille Lindsø Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjørup Sækmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
{"title":"Two Novel Human Leukocyte Antigen Alleles Are Associated with Decreased Risk of Onychomycosis in a Large Cohort of Danish Blood Donors.","authors":"Pernille Lindsø Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjørup Sækmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte","doi":"10.1159/000529092","DOIUrl":"10.1159/000529092","url":null,"abstract":"<p><strong>Introduction: </strong>Antigen presentation and antimicrobial immune responses involve the human leukocyte antigen (HLA) system. Onychomycosis is primarily caused by dermatophytes and affects around 5.5% of the population worldwide. Yet, only limited data exist on the associations between the HLA system and onychomycosis. Thus, the objective of the study was to investigate if there is an association between HLA alleles and onychomycosis.</p><p><strong>Methods: </strong>Participants in the Danish Blood Donor Study were defined as cases of onychomycosis and controls based on antifungal prescriptions in the national prescription registry. Associations were investigated using logistic regressions adjusted for confounders and were Bonferroni corrected for multiple tests.</p><p><strong>Results: </strong>A total of 3,665 participants were considered onychomycosis cases, and 24,144 participants were considered controls. We found two protective HLA alleles of onychomycosis: DQB1*06:04, odds ratios (OR) 0.80 (95% confidence interval (CI) 0.71-0.90), and DRB1*13:02, OR 0.79 (95% CI: 0.71-0.89).</p><p><strong>Conclusion: </strong>The finding of two novel protective alleles of onychomycosis indicates that certain HLA alleles have certain antigen presentation properties affecting the risk of fungal infection. These findings may provide the basis for future research identifying immunologically relevant antigens of fungi causing onychomycosis, which could ultimately lead to targets of new drugs with antifungal effects.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"195-202"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis F Andrade, Kayla D Mashoudy, Brian Morrison, Antonella Tosti
{"title":"Monodactylous Longitudinal Melanonychia in Pediatric Skin of Color: A Case Series and Review.","authors":"Luis F Andrade, Kayla D Mashoudy, Brian Morrison, Antonella Tosti","doi":"10.1159/000529361","DOIUrl":"10.1159/000529361","url":null,"abstract":"<p><strong>Introduction: </strong>Longitudinal melanonychia, a pigmented longitudinal streak on the nail, is a common clinical finding that may be associated with subungual melanoma with varying presentation depending on race and skin tone. It has been long reported that darker skinned ethnicities have a higher prevalence of longitudinal melanonychia in the US population (e.g., African Americans with 77% prevalence) [Indian J Dermatol. 2021;66(4):445], but unfortunately, there are limited studies exclusively looking at longitudinal melanonychia in pediatric patients of color.</p><p><strong>Case presentation: </strong>In this case series, we review the current literature and report the findings of 8 cases of longitudinal melanonychia in children with skin types IV or greater. Out of the 8 cases identified, only 4 returned to the clinic for monitoring (<i>n</i> = 4), and there was an average of 20.8 months between the initial and final visits. Of the patients that returned for follow-up, 2 showed no relevant changes in the nail pigmentation, 1 showed fading of the band, and 1 patient showed enlargement of the band to involve the whole nail.</p><p><strong>Conclusion: </strong>Although many sources recommend a conservative approach to treatment that involves monitoring and follow-up, our findings indicate that a wait-and-see method cannot be applied to all cases in the pediatric population due to disruptions in continuity of care. An individualized approach considering such factors should be employed for each patient, and certain high-risk features of the ABCDEF nail melanoma model may be relevant in pediatric cases.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"224-229"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nail Amyloidoma: Two Case Reports of a New Entity.","authors":"Frederico Bonito, Athanassios Kolivras, Ursula Sass, Bertrand Richert","doi":"10.1159/000529091","DOIUrl":"10.1159/000529091","url":null,"abstract":"<p><strong>Introduction: </strong>Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity.</p><p><strong>Case presentation: </strong>Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up.</p><p><strong>Conclusion: </strong>These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"216-220"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thyroid Diseases in a Cohort of Finnish Patients with Hidradenitis Suppurativa.","authors":"Nicolas Kluger","doi":"10.1159/000529907","DOIUrl":"10.1159/000529907","url":null,"abstract":"<p><strong>Introduction: </strong>The association between thyroid disorders (hyperthyroidism or hypothyroidism) and hidradenitis suppurativa is controversial. Our study aimed to determine the phenotype and comorbidities of HS patients with thyroid disorders.</p><p><strong>Methods: </strong>A retrospective study was conducted in the department of dermatology, Helsinki University Hospital, Finland, and included all the attending patients with HS diagnosis in 2018.</p><p><strong>Results: </strong>A total of 167 patients were included (97 women). The prevalence of thyroid disorders was 12% and of hypothyroidism 10.7%. Patients with thyroid disorders were more likely to have a BMI ≥25 (<i>p</i> = 0.016), asthma (<i>p</i> = 0.034) and to be nonsmoker (<i>p</i> = 0.018) or ex-smoker (<i>p</i> = 0.017). Binary logistic regression showed that only asthma and nonsmoking were associated with thyroid disorders or hypothyroidism among patients with HS.</p><p><strong>Conclusion: </strong>Our study is in line with previous ones that showed the association of HS and thyroid disorders in nonsmokers. Asthma may be simply an association with thyroid disorders and unrelated to HS as such.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"191-194"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niccolò Capurro, Astrid Herzum, Emanuele Cozzani, Martina Burlando, Silvia Riva, Michele Paudice, Aurora Parodi
{"title":"Usefulness of Dermoscopy in Eruptive Syringomas in an Elderly Woman.","authors":"Niccolò Capurro, Astrid Herzum, Emanuele Cozzani, Martina Burlando, Silvia Riva, Michele Paudice, Aurora Parodi","doi":"10.1159/000528804","DOIUrl":"10.1159/000528804","url":null,"abstract":"<p><strong>Introduction: </strong>Eruptive syringomas (ES) are a rare variant of syringomas, benign adnexal tumors of eccrine sweat glands' ducts. They mostly affect young-to middle-aged women, but rarely they may also occur in the elderly, requiring generally no specific treatment.</p><p><strong>Case presentation: </strong>We present the case of a 76-year-old woman with sudden onset of ES. Clinical examination evidenced brown-to-orange papules and plaques on the anterior neck, corresponding dermatoscopically to orange-brownish structureless areas, with barely hinted peripheral incomplete network, superimposed on areas of light pink. Histology showed dermal proliferation of epithelial cells forming cords and ductules, confirming the clinical-dermoscopic suspect of ES. The lesions remained stable at 12-month follow-up without treatment.</p><p><strong>Discussion: </strong>This case highlights the role of dermoscopy to help differentiate ES from other clinically similar but more serious entities, such as histiocytosis, mastocytosis, and lichen planus, and to schedule the required confirmatory biopsy in due time without haste.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"144-146"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria J Lalama, Betty Nguyen, Erik L Peterson, Antonella Tosti
{"title":"Utility of Teledermatology in the Diagnosis of Loose Anagen Syndrome.","authors":"Maria J Lalama, Betty Nguyen, Erik L Peterson, Antonella Tosti","doi":"10.1159/000527651","DOIUrl":"10.1159/000527651","url":null,"abstract":"<p><strong>Introduction: </strong>Teledermatology has been shown to improve efficiency and reduce barriers to care for patients. However, teledermatology is limited by the inability to perform diagnostic tests. With proper planning, teletrichoscopy can be utilized with teledermatology to evaluate patients with hair loss.</p><p><strong>Case presentation: </strong>Diagnosis of this patient was made using images taken during the televisit, including scalp images taken by the patient using a handheld microscope and images of the hair roots taken by her referring doctor.</p><p><strong>Conclusion: </strong>Hair tests that can be conducted during teledermatology visits include a self-performed pull test, measurement of the thickness of the ponytail, measurement of the distance from the hairline to the glabella, and evaluation of the shedding scale. These tests, in addition to mobile applications for imaging or low-cost handheld microscopes, can be utilized to virtually evaluate patients with hair loss.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"137-140"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Matricectomy with Electrocautery as Therapy for Recurrent Ingrown Toenail.","authors":"Nugrohoaji Dharmawan, Putri Oktriana Rachman, Adniana Nareswari, Ummi Rinandari, Achmad Fiqri, Eka Devinta","doi":"10.1159/000528517","DOIUrl":"10.1159/000528517","url":null,"abstract":"<p><strong>Introduction: </strong>Ingrown toenails are one of the common nail problems generally occurs in the big toe area and most often occurs during productive ages. Treatment of ingrowing toenail can be chosen based on the clinical condition of the patient. Nonoperative therapy is not effective in advanced cases in terms of the severity. Improper handling will cause recurrence in this case.</p><p><strong>Case presentation: </strong>Six of 8 patients had the ingrown toenail recurrence previously treated using the nail avulsion (onychectomy) without matricectomy. One patient was reported to have hemophilia as comorbidity. The other one had pincer nail associated with inflammatory and degenerative processes. Most patients were at modified Mozena grades III and IV ingrown toenail. Post therapy evaluation revealed no recurrence in all patients.</p><p><strong>Conclusions: </strong>Combination of wedge resection with matricectomy using electrocautery can be applied as therapy for recurrent ingrown toenail.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 2","pages":"126-136"},"PeriodicalIF":1.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}