Skin Appendage Disorders最新文献_第9页

Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program. 侏儒症与皮肤病和血管病有关：我们所有人研究计划的病例对照研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-20 DOI: 10.1159/000530096

Zi-Ning Choo, Shari R Lipner

引用次数: 0

Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit. 指甲部位盘状红斑狼疮引发的鳞状细胞癌

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-15 DOI: 10.1159/000529360

Tatiana Mina Yendo, Tatiana Villas Boas Gabbi, Marcello Menta Simonsen Nico

引用次数: 0

Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa. 血清淀粉样蛋白 A：化脓性扁平湿疹严重程度的潜在新标志物

IF 1.4

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-20 DOI: 10.1159/000528658

Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini

{"title":"Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa.","authors":"Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1159/000528658","DOIUrl":"10.1159/000528658","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.Methods: Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.Results: SAA levels were significantly associated with number of nodules (p = 0.005), abscesses (p < 0.001), fistulas (p = 0.016), and severe IHS4 (p = 0.088 and r = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.Conclusions: We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"165-168"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series of Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution: Is There a Familial Correlation? 额部纤维性脱发和花纹分布的纤维性脱发病例系列：是否存在家族相关性？

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-30 DOI: 10.1159/000529923

Maria Fernanda Reis Gavazzoni Dias, Amanda Lofeu Cury, Enoi Aparecida Guedes Vilar, Patricia Guimarães Peixoto, Chloe Ekelem

引用次数: 0

Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features. 阿达木单抗诱发的银屑病性脱发和矛盾性银屑病可使用赛妥珠单抗成功治疗：临床、三镜和体内反射共聚焦显微镜特征。

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2022-12-08 DOI: 10.1159/000527985

Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza

{"title":"Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features.","authors":"Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza","doi":"10.1159/000527985","DOIUrl":"10.1159/000527985","url":null,"abstract":"Introduction: Psoriatic alopecia is considered a type of hair loss occurring in patients with psoriasis. Adalimumab is a fully humanized recombinant anti-TNF-alpha monoclonal antibody approved for treatment of psoriasis and psoriatic arthritis (PsA), rarely related to the occurrence of dermatological disorders.Case presentation: We report the case of a 56-year-old female with PsA developing psoriatic alopecia and paradoxical psoriasis induced by adalimumab and successfully treated switching to certolizumab, evaluating response at both thrichoscopy and in vivo reflectance confocal microscopy.Discussion: Among anti-TNF-α agents, certolizumab is the least involved in the development of paradoxical reactions such as psoriatic alopecia and showed to be an effective and safe alternative therapeutic options to manage psoriasis and PsA minimizing the risk of paradoxical reactions.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"207-210"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Infection in Hidradenitis Suppurativa Patients: A Retrospective Study. 化脓性汗腺炎患者COVID-19感染的回顾性研究

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 DOI: 10.1159/000529462

Devea R De, Jonathan W Rick, Terri Shih, Jennifer L Hsiao, Iltefat Hamzavi, Vivian Y Shi

{"title":"COVID-19 Infection in Hidradenitis Suppurativa Patients: A Retrospective Study.","authors":"Devea R De, Jonathan W Rick, Terri Shih, Jennifer L Hsiao, Iltefat Hamzavi, Vivian Y Shi","doi":"10.1159/000529462","DOIUrl":"https://doi.org/10.1159/000529462","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is associated with comorbidities that are risk factors for severe COVID-19 infection. We evaluated demographics and COVID-19 outcomes in HS patients.Methods: HS patients with COVID-19 (HS+/COVID+) and a randomized age-, race-, and sex-matched control population of patients without HS with COVID-19 (HS-/COVID+) were selected through a retrospective chart review. Data were collected on demographics, medications, comorbidities, vaccination status, and COVID-19 treatment/outcomes. Fisher's exact test was used to analyze the relationship between risk factors and COVID-19 outcomes. A p value of <0.05 was considered statistically significant.Results: There were 58 HS+/COVID+ patients, primarily African American (83%, n = 48) and female (88%, n = 51). Compared to HS+/COVID+ patients, HS-/COVID+ patients were significantly more likely to have cardiovascular disease (51% vs. 24%; p = 0.0029) and be pregnant (23% vs. 4%; p = 0.0093). HS+/COVID+ and HS-/COVID+ patients did not vary significantly in vaccination rate at time of COVID-19 diagnosis (6% vs. 5%; p = 0.78). HS-/COVID+ patients were significantly more likely to have COVID-19 complications (35% vs. 7%; p = 0.001) and receive COVID-19 treatment (37% vs. 7%; p = 0.0001) when compared to HS+/COVID+ patients.Conclusion: Our findings support the growing evidence that having HS itself may not be a risk factor for severe COVID-19 outcomes.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"203-206"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alopecia Areata Barbae in a Nutshell. 毛囊性脱发简述

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-08 DOI: 10.1159/000529389

Adaeze Nwosu, Mariya Miteva

{"title":"Alopecia Areata Barbae in a Nutshell.","authors":"Adaeze Nwosu, Mariya Miteva","doi":"10.1159/000529389","DOIUrl":"10.1159/000529389","url":null,"abstract":"Beard alopecia areata, or alopecia areata barbae, (BAA) is a subset of alopecia areata, a T-cell mediated inflammatory disease that disrupts the hair follicle cycle leading to early onset of catagen. The aim of this review is to help strengthen clinicians' skills in the evaluation, diagnosis, and management of BAA. We performed a literature review according to the modified PRISMA guidelines, using a combination of relevant key words in electronic databases. According to the data from the 25 articles on BAA reviewed here, BAA mostly affects middle-aged men (mean age 31 years) who typically experience patchy hair loss in the neck region, which spreads to the scalp within 12 months. Similar to AA, BAA is associated with autoimmune diseases such as H. pylori and thyroiditis; however, BAA has no clear genetic pattern of inheritance which is observed in alopecia areata. Common dermoscopic findings in BAA include vellus white hairs and exclamation mark hairs, which may help distinguish it from other pathologies affecting facial hair. In clinical trials, the ALBAS tool offers clinicians an objective metric to evaluate BAA severity. Until recently, topical steroids have been the mainstay therapy; however, topical and oral janus kinase inhibitors are achieving improved results, with up to 75% beard regrowth in an average of 12 months.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"179-186"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin in Hidradenitis Suppurativa: Is It Worth Pursuing Further? 二甲双胍治疗化脓性扁桃体炎：值得继续研究吗？

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-29 DOI: 10.1159/000529359

Aikaterini Tsentemeidou, Efstratios Vakirlis, Ilias Papadimitriou, Dimitrios Ioannides, Elena Sotiriou

{"title":"Metformin in Hidradenitis Suppurativa: Is It Worth Pursuing Further?","authors":"Aikaterini Tsentemeidou, Efstratios Vakirlis, Ilias Papadimitriou, Dimitrios Ioannides, Elena Sotiriou","doi":"10.1159/000529359","DOIUrl":"10.1159/000529359","url":null,"abstract":"Hidradenitis suppurativa (HS) often coexists with obesity, metabolic syndrome, diabetes mellitus, or impaired glucose tolerance and insulin resistance and polycystic ovarian syndrome. Metformin is a medication used for the treatment of diabetes, acting in multiple ways. There is evidence that it decreases inflammatory cytokines, some of which are implicated in the pathogenesis of HS (TNF-α, IL-17). We performed a systematic review of data regarding the efficacy and safety of metformin for the treatment of HS. Four electronic databases (MEDLINE, ScienceDirect, Cochrane Library, and ClinicalTrials.gov), as well as the abstracts compendia of major dermatologic congresses, were searched. A total of 133 patients received metformin for HS across 6 studies, 117 of whom received it as monotherapy. The great majority of participants were female, in their thirties and overweight or obese, with one study including only children. The efficacy tools employed varied widely. Four studies (106 patients) documented improvement, 1 documented treatment failure, and 1 had mixed results. Only mild and transient side effects were noted. Metformin has been tried in few HS patients with acceptable efficacy in a fair number of them. As it is generally well tolerated and reasonably priced, carefully designed clinical trials comparing it with placebo are worth performing.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"187-190"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalp Seborrheic Dermatitis: What We Know So Far. 头皮脂溢性皮炎：我们目前所知

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-04-05 DOI: 10.1159/000529854

Anne Kelly Leroy, Rita Fernanda Cortez de Almeida, Daniel Lago Obadia, Sidney Frattini, Daniel Fernandes Melo

引用次数: 0

Hidradenitis Suppurativa and Five Key Vitamins and Minerals. 化脓性扁桃体炎与五种关键维生素和矿物质

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-23 DOI: 10.1159/000528122

Sydney Alexis Weir, Brittany Roman, Victoria Jiminez, Meredith Burns, Adaugo Sanyi, Boni Elewski, Tiffany Mayo

{"title":"Hidradenitis Suppurativa and Five Key Vitamins and Minerals.","authors":"Sydney Alexis Weir, Brittany Roman, Victoria Jiminez, Meredith Burns, Adaugo Sanyi, Boni Elewski, Tiffany Mayo","doi":"10.1159/000528122","DOIUrl":"10.1159/000528122","url":null,"abstract":"Hidradenitis suppurativa (HS), a chronic inflammatory disease characterized by painful abscesses and nodules, has limited effective treatment options. However, adjuncts to standard therapeutics such as dietary modifications have been increasingly investigated in recent years. This comprehensive review aimed to analyze the literature concerning the relationship between HS and 28 essential vitamins and minerals. A literature search was performed via PubMed, Embase, Ovid, and Scopus using search terms related to HS and the essential vitamins and minerals. A total of 215 unique articles were identified and analyzed. Twelve essential nutrients had documented associations with HS; definitive supplementation or monitoring recommendations were identified for 7 of the 12 HS-associated nutrients in the literature. Evidence is growing that supports adjunct supplementation of zinc, vitamin A, and vitamin D in the treatment of HS. Further, obtaining serum levels of zinc, vitamin A, vitamin D, and vitamin B12 upon initial diagnosis of HS may be beneficial to optimize standard HS treatment. In conclusion, optimizing nutrition in addition to standard HS therapeutics may help reduce disease burden; however more research is needed.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"153-159"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0