Skin Appendage Disorders最新文献

{"title":"Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study","authors":"Alexandros Katoulis, Ourania Efthymiou, Aikaterini Liakou, Georgia Pappa, Antonios Kanelleas, Dimitra Koumaki, Evangelia Bozi, Dimitrios Sgouros","doi":"10.1159/000531926","DOIUrl":"https://doi.org/10.1159/000531926","url":null,"abstract":"<b><i>Introduction:</i></b> Treatment of hidradenitis suppurativa (HS) is challenging, and in Hurley stage I, it is based on topical measures. Our aim was to compare the efficacy and safety of topical resorcinol 10% with topical clindamycin 1% and no therapy, in Hurley stage I HS. <b><i>Methods:</i></b> In this open, prospective, randomized trial, we studied 60 Hurley stage I patients with IHS4 ≤10. Group A was treated with topical resorcinol 10%; group B with clindamycin lotion 1%; and group C received no treatment. Patients were evaluated by total lesion count, the International Hidradenitis Suppurativa Severity Score System (IHS4) and the Dermatology Life Quality Index (DLQI) at baseline, 12 and 24 weeks. Self-reported number of flares and adverse events (AEs) were recorded. <b><i>Results:</i></b> A significant reduction in the mean total lesion count and DLQI scores were observed in group A, compared to group B at week 12 (<i>p</i> = 0.036, <i>p</i> &amp;lt; 0.001, respectively), and in the mean total lesion count, IHS4, and DLQI scores at week 24 (<i>p</i> = 0.034, <i>p</i> = 0.017, <i>p</i> &amp;lt; 0.001, respectively). Resorcinol 10% was well-tolerated with only mild AEs. <b><i>Conclusion:</i></b> Resorcinol 10% may represent a useful alternative for the long-term treatment of mild HS, which is superior to topical clindamycin and has a favorable safety profile.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135021897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail Unit Arteriovenous Hemangioma Presenting as Longitudinal Erythronychia.","authors":"Jonathan K Hwang, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000530739","DOIUrl":"10.1159/000530739","url":null,"abstract":"<p><strong>Introduction: </strong>Localized longitudinal erythronychia is defined as a single nail with a longitudinal red band extending the length of a nail plate. It has a broad differential of benign and malignant etiologies, and is rarely due to benign vascular proliferations.</p><p><strong>Case presentation: </strong>We present a unique case of nail unit arteriovenous hemangioma presenting as longitudinal erythronychia of the left thumbnail in a 76-year-old male. The band was 6 mm and encompassed over 40% of the surface area of the nail plate. Dermoscopy showed red bands that were regular in terms of color, but not thickness or spacing. Due to concern for an amelanotic melanoma, a longitudinal excision was performed. Histopathology was consistent with a diagnosis of nail unit arteriovenous hemangioma.</p><p><strong>Conclusion: </strong>Arteriovenous hemangiomas were rarely present in the nail unit. They can be present as a blue or red nodule/macule, or as longitudinal erythronychia. Diagnosis often requires an excisional biopsy, with histopathology notable for a proliferation of multiple thick- and thin-walled vascular structures lined by a flattened endothelium. Our case emphasizes the need to consider vascular proliferations, such as arteriovenous hemangioma, in the differential diagnosis of longitudinal erythronychia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"300-305"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subungual Keratoacanthoma: Typical and Atypical Presentations of an Uncommon Nail Tumor.","authors":"Grecia Figueroa-Ramos, Michelle Gatica-Torres, Karla López-López, Judith Domínguez-Cherit","doi":"10.1159/000529724","DOIUrl":"10.1159/000529724","url":null,"abstract":"<p><strong>Introduction: </strong>Keratoacanthoma (KA) is a group of tumors of epidermal origin with controversial nature. Subungual keratoacanthoma (SUKA) is a rare and destructive variant with more aggressive behavior. SUKA appears as a rapidly growing, painful tumor beneath the nail plate that rapidly progresses to a mass that can measure up to 2 cm. The toe location is unusual. The diagnosis must be made based on the correlation of clinical, radiological, and histopathological findings.</p><p><strong>Case presentation: </strong>We present two cases of patients diagnosed with SUKAs with different clinical presentations which ranged from very typical to uncommon one. Both cases were treated with simple excision without recurrences.</p><p><strong>Conclusion: </strong>SUKA is a rare subungual tumor. Nail bed location represents a more difficult diagnostic challenge. SUKA should be suspected in the context of persistent and progressive pain on a finger or toe, once more frequent painful tumors have been ruled out.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"291-295"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Session Fractional CO₂ Laser following Urea Occlusion in Management of Onychomycosis: A Pilot Study.","authors":"Eeshaan Ranjan, Sandeep Arora, Ajay Shanker Sharma, Neha Sharma, Rajeshwari Dabas","doi":"10.1159/000527252","DOIUrl":"10.1159/000527252","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is a common nail disorders. Antifungal resistance, interactions, and side effects limit treatment options. Fractional CO₂ (FCO₂) laser along with topical antifungal is effective in multiple monthly sessions. A modification reducing repeated visits and hence better compliance is preferable. Single-session FCO₂ laser following urea occlusion is reported to be effective. Thus, we conducted a study to determine the efficacy of single-session FCO₂ laser with 1% terbinafine cream with and without \"urea cream occlusion\" in managing onychomycosis.</p><p><strong>Methods: </strong>A prospective, randomized, parallel-group study was conducted at a tertiary centre. Onychomycosis was confirmed by positive fungal mount and culture. Patients were randomized into 2 groups and administered single-session FCO₂ laser. Group A was treated after overnight urea cream occlusion and group B without occlusion. Both groups applied 1% terbinafine cream twice daily for 3 months. Response was assessed by improvement in Onychomycosis Severity Index (OSI) at 6 months.</p><p><strong>Results: </strong>Group A had 10 patients, 14 nails. Clinical improvement was seen in 12/14 (85.7%) nails. Average reduction in OSI was 10.78. Group B had 10 patients, 11 nails. Clinical improvement was seen in 5/11 (45.5%) nails. Average reduction in OSI was 1.73. \"Reduction in OSI\" was statistically significant (<i>p</i> < 0.05) only in group A.</p><p><strong>Conclusion: </strong>Single-session FCO₂ laser following overnight urea cream occlusion, followed by 1% terbinafine cream, is effective for management of onychomycosis.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"268-274"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopic Findings Post Hair Restoration Surgery.","authors":"Leila David Bloch, Helena Rocchetto","doi":"10.1159/000530856","DOIUrl":"10.1159/000530856","url":null,"abstract":"<p><strong>Introduction: </strong>Trichoscopy is a noninvasive diagnostic method for hair and scalp diseases. Data on trichoscopy post hair restoration surgery are limited, and some authors show no relevant changes.</p><p><strong>Case presentation: </strong>Trichoscopic findings in 45 patients are described, after being followed for 12 months after hair restoration surgery. They evolved without any hair disease.</p><p><strong>Conclusion: </strong>Trichoscopy showed some hair shaft abnormalities previously described in alopecia areata and chemotherapy-induced alopecia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"306-308"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopy as a Tool to Evaluate Early Dissecting Cellulitis in Patients Affected by Hidradenitis Suppurativa: A Prospective Monocentric Observational Study.","authors":"Marco May Lee, Luigi Naldi, Bianca Maria Piraccini, Michela Starace, Aurora Alessandrini, Andrea Sechi","doi":"10.1159/000530630","DOIUrl":"10.1159/000530630","url":null,"abstract":"<p><strong>Background: </strong>Dissecting cellulitis (DC) is a rare neutrophilic dermatosis that leads to cicatricial alopecia. Although DC and Hidradenitis suppurativa (HS) have similar characteristics, their association remains poorly understood.</p><p><strong>Objectives: </strong>In this prospective observational study, we used trichoscopy to identify subclinical signs of DC in male patients aged 18 years or older, presenting with HS. The objective of this study was to use trichoscopy to identify subclinical signs of DC in patients with confirmed diagnosis of HS.</p><p><strong>Method: </strong>In this prospective, monocentric, observational study, we used trichoscopy to identify subclinical signs of DC in male patients aged 18 years or older, presenting with HS for their initial visit at our HS outpatient clinic from February 1, 2022, to January 31, 2023.</p><p><strong>Results: </strong>Of the 23 male patients with HS, 8 (35%) had subclinical trichoscopy findings consistent with DC. The most frequent location was the vertex (6/8), and the majority of patients had early/inflammatory trichoscopic signs of DC (5/8). Additionally, patients with trichoscopic findings consistent with DC had a higher Hurley stage and the International Hidradenitis Suppurativa Severity Score System (IHS4). Among the cases with trichoscopic findings compatible with DC, the majority (6/8) were classified as having a \"follicular\" HS according to the Canoui-Poitrine classification. Patients were treated according to European S1 guidelines on HS.</p><p><strong>Conclusions: </strong>This is the first study to evaluate subclinical DC findings in HS patients using trichoscopy. Although the trichoscopic findings of DC are heterogeneous, the use of this non-invasive technique, in conjunction with clinical evaluation, can improve diagnostic accuracy and lead to earlier diagnosis. These findings suggest a potential association between HS and DC, indicating the need for further studies to evaluate this relationship.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"275-279"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Type of Radiation-Induced Alopecia: Proton-Induced Alopecia.","authors":"Davide Fattore, Vincenzo Picone, Maria Vastarella, Gabriella Fabbrocini, Maria Teresa Cantelli","doi":"10.1159/000530152","DOIUrl":"10.1159/000530152","url":null,"abstract":"<p><strong>Introduction: </strong>Radiation-induced alopecia (RIA) is a side effect resulting from cranial radiation therapy (RT) and it can be temporary or permanent. In cancer patients, RIA is a less frequent event than chemotherapy-induced alopecia, although the former is more likely to cause permanent hair loss. It is characterized initially by intense anagen effluvium caused by acute dose-dependent damage to the matrix cells of anagen follicles. Proton therapy (PT) is a specific type of RT used in the treatment of brain tumors, which sometimes can cause proton-induced alopecia (PIA), a rare subtype of RIA. Below, we report a case of a patient who presented PIA following PT treatment of a meningioma of the frontal region.</p><p><strong>Case presentation: </strong>A 38-year-old female patient presented to our trichology outpatient clinic for widespread hair loss in the frontal region. Following a diagnosis of meningioma of the frontal region 3 years ago, adjuvant radiotherapy treatment of the frontal region with scanning beam PT (mean dose of 45 Gy) was performed. Two weeks after the end of treatment, the patient came to our attention with diffuse hair loss at the level of the PT-treated area. Trichoscopy showed flame hairs, broken hairs, black dots, and pigtail hairs. A diagnosis of PIA was established, and topical treatment with minoxidil 5% solution twice a day was initiated. At the follow-up visit after 4 months, the patient had total hair regrowth.</p><p><strong>Conclusion: </strong>PIA is a subtype of RIA still poorly studied in the literature. Hair loss is caused by aggression by radiations of the hair follicle in the anagen phase, leading to an interruption of the mitotic activity of the matrix cells. The cells of the follicular bulb are characterized by marked mitotic activity at this stage and are consequently more susceptible to cytotoxic damage. All this causes tightening of the proximal portion of the hair shaft, increasing its fragility and susceptibility to breakage.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"280-283"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Polarized Photography of the Nail Unit: A Practical Way to Eliminate Specular Reflections on the Nail Plate.","authors":"Fatih Göktay, Ozan Erdem","doi":"10.1159/000530670","DOIUrl":"10.1159/000530670","url":null,"abstract":"","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"313-316"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiencing Workplace Bullying in Patients with Alopecia Areata: A Cross-Sectional Survey Study.","authors":"Sara J Li, Sophia Reyes-Hadsall, Lara Drake, Kathie Huang, Arash Mostaghimi","doi":"10.1159/000529924","DOIUrl":"10.1159/000529924","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an immune-mediated hair loss condition with substantial psychosocial impact. The impact of AA on social interactions at work has not been established.</p><p><strong>Methods: </strong>We administered the Negative Acts Questionnaire-Revised Scale to the National Alopecia Areata Foundation database to evaluate workplace bullying in patients with AA.</p><p><strong>Results: </strong>Ultimately, 673/1,120 individuals who met inclusion criteria completed the survey. Most respondents were female (<i>n</i> = 537, 79.8%), Caucasian (<i>n</i> = 508, 75.5%), with an average age of 46.8 ± 14, and employed full-time (<i>n</i> = 427, 63.4%). Our results demonstrate 21.7% (<i>n</i> = 146) of respondents experienced workplace bullying. Participants most frequently faced having their opinions ignored (53.8%, <i>n</i> = 362), being excluded (47.7%, <i>n</i> = 321), and having gossip spread about them (44.0%, <i>n</i> = 296). Notably, 75.0% (<i>n</i> = 120/160) of individuals who self-reported bullying addressed the behavior; however, 30.8% of participants noted the bully continued (30.8%, <i>n</i> = 37). Stress associated with filing a complaint (43.5%, <i>n</i> = 293) and effect on future career options (36.1%, <i>n</i> = 243) were common barriers to report bullying.</p><p><strong>Conclusion: </strong>This study expands our understanding of the psychosocial impact of AA by confirming individuals with AA experience workplace bullying. Stigma against patients may play a role in this phenomenon. Future work is warranted to identify strategies to reduce bullying against patients with AA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"258-261"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Scoring and Assessment of Keratosis Pilaris.","authors":"Madeline A Wang, Anna Wilson, Dédée F Murrell","doi":"10.1159/000529487","DOIUrl":"10.1159/000529487","url":null,"abstract":"<p><p>Disease severity assessment tools play a large part in evaluating skin conditions in dermatology. Currently, there is no existing validated assessment tool for keratosis pilaris (KP), a benign yet highly prevalent follicular disorder. A range of proposed scoring tools have been used in different clinical trials for the assessment of potential treatments for KP. A literature review of the current scoring systems used for KP shows that there is a lack of consistency with most studies using varying versions of unvalidated investigator global assessment (IGA) scores and quartile grading systems. A review of these studies shows that current methods of evaluating KP in clinical trials are subjective, unreliable, and inconsistent. A standardised and validated scoring system would be significant as it could be used in clinical trials to advance the current knowledge of KP.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"241-251"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}