Skin Appendage Disorders最新文献

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Responsiveness of the Dermatology Life Quality Index and the Colombian Validated Version of the Skindex-29 in Scarring and Non-Scarring Alopecia. 皮肤病学生活质量指数和哥伦比亚验证版皮肤指数-29在瘢痕性和非瘢痕性脱发中的反应性。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-01 DOI: 10.1159/000541603
Jurany Sanchez, Cristian Mora, Gener Alejandro Mancilla, Gloria Sanclemente
{"title":"Responsiveness of the Dermatology Life Quality Index and the Colombian Validated Version of the Skindex-29 in Scarring and Non-Scarring Alopecia.","authors":"Jurany Sanchez, Cristian Mora, Gener Alejandro Mancilla, Gloria Sanclemente","doi":"10.1159/000541603","DOIUrl":"10.1159/000541603","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia is a frequent reason for consultation and is often associated with psychological, self-esteem, and quality of life (QoL) impact, particularly in women. To date, QoL assessment studies including all alopecia types are lacking. This study evaluated QoL and sensitivity to change of the Skindex-29 and the Dermatology Life Quality Index (DLQI) in these.</p><p><strong>Methods: </strong>This was an observational study with a longitudinal design, including two measurements over time and prospective data. It was carried out in four outpatient centers in Medellín, between 2023 and 2024. We included sociodemographic and clinical data, as well as the DLQI and Skindex-29 QoL questionnaires before and after treatment.</p><p><strong>Results: </strong>Participation of women was 51%; the most frequent types of alopecia were androgenic alopecia (52%), alopecia areata (AA) (19%), and telogen effluvium (TE) (9%). The alopecia types with the greatest impact on QoL (pretreatment) measured through the DLQI and the Skindex-29, respectively, were TE (10.29 [±9.32] and 40.39 [±32.04]), AA (9.27 [±9.13], and 33.91 [±26.47]), dissecting cellulitis (8.67 [±8.33] and 29.6 [±15.33]), and lichen planus pilaris (6.75 [±6.55] and 6.75 [±6.55]).</p><p><strong>Conclusion: </strong>The version validated in Colombia of the Skindex-29 and the Colombian Spanish version of the DLQI showed a moderate responsiveness when evaluating the QoL of patients with scarring and non-scarring alopecia, before and after starting specific treatment.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"135-142"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trichoscopy of Pemphigus Vulgaris and Foliaceus on Black Scalp. 黑色头皮寻常型天疱疮和叶状癣的毛镜检查。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-15 DOI: 10.1159/000540968
Marcela Duarte Benez-Miller, Alexandre Gripp, Daniel Fernandes Melo, Carla Jorge Machado, Marta Sar-Pomian, Luna Azulay-Abulafia
{"title":"Trichoscopy of Pemphigus Vulgaris and Foliaceus on Black Scalp.","authors":"Marcela Duarte Benez-Miller, Alexandre Gripp, Daniel Fernandes Melo, Carla Jorge Machado, Marta Sar-Pomian, Luna Azulay-Abulafia","doi":"10.1159/000540968","DOIUrl":"10.1159/000540968","url":null,"abstract":"<p><strong>Introduction: </strong>Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are bullous diseases characterized by loss of keratinocyte adhesion, easily ruptured blisters, and erosions. The scalp is involved in up to 60% of patients due to the high concentration of antigens in hair follicles. Trichoscopy has been studied in bullous diseases. However, research on pemphigus trichoscopy remains scarce. This study aimed to analyze the main trichoscopic features of pemphigus on the black scalp, a topic poorly appraised thus far.</p><p><strong>Methods: </strong>Ten male and 8 female patients were enrolled, evenly distributed between PV (aged 16-59) and PF (aged 20-72), with Fitzpatrick phototypes equal to or greater than IV. Scalp evaluations were conducted using digital dermoscopy, with 20-to-70-fold magnification. Our results were compared with original research on Caucasian scalp pemphigus.</p><p><strong>Results: </strong>Our study identified the previously published and also novel trichoscopic features. Our patients exhibited higher percentages (<i>p</i> < 0.05) of eight classic structures, considering both PF and PV; PF only; PV only. Aside from yellow dots (<i>p</i> = 0.002), our sample showed no statistically significant differences between the PV and PF groups in black patients.</p><p><strong>Conclusion: </strong>Peculiarities of black scalp trichoscopy did not interfere in the diagnosis of pemphigus. Trichoscopy should be a routine diagnostic tool in patients with bullous scalp diseases, especially in the early stages, and to guide biopsy. To our knowledge, this is the first study focused on trichoscopy of pemphigus affecting black scalp. It indicates that, among other findings, yellow dots may be a relevant hallmark of scalp PV.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"147-150"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-Onset Eccrine Angiomatous Hamartoma Associated with Lower Extremity Venous Insufficiency: A Case Report. 成人起病的胰腺血管瘤错构瘤伴下肢静脉功能不全1例报告。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI: 10.1159/000541808
Isabela Dorado Caycedo, Juan C H López Takegami, Eduardo A Rivera Perdomo, Claudia P González Díaz
{"title":"Adult-Onset Eccrine Angiomatous Hamartoma Associated with Lower Extremity Venous Insufficiency: A Case Report.","authors":"Isabela Dorado Caycedo, Juan C H López Takegami, Eduardo A Rivera Perdomo, Claudia P González Díaz","doi":"10.1159/000541808","DOIUrl":"10.1159/000541808","url":null,"abstract":"<p><strong>Introduction: </strong>Eccrine angiomatous hamartoma (EAH) is a benign tumor characterized by the proliferation of eccrine glands and vascular structures. It can be congenital or appear during childhood, with rare cases arising in adults. EAH typically presents as a solitary purplish plaque or nodule but a multifocal presentation in a blaschkoid or segmental distribution has been described.</p><p><strong>Case presentation: </strong>We report the case of an extensive EAH following the territory of the superficial veins of the lower limbs, arising in an adult diagnosed with venous insufficiency at a young age and that worsened after saphenectomy.</p><p><strong>Conclusion: </strong>The histopathological and ultrasonographic characteristics suggest that this case may represent a new instance of EAH associated with arteriovenous malformation. We hypothesize that there might be common molecular pathways linking both conditions and that, in predisposed patients, saphenectomy can exacerbate EAH.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"202-206"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Trichoscopy Suggest the Agent in Tinea Capitis? 毛发镜检查能提示头癣的诱因吗?
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-24 DOI: 10.1159/000541672
Luna Azulay-Abulafia, Gabriela Giraldelli, Ana Luisa Alves, Jessica Baka, Felipe Tavares Rodrigues
{"title":"Can Trichoscopy Suggest the Agent in Tinea Capitis?","authors":"Luna Azulay-Abulafia, Gabriela Giraldelli, Ana Luisa Alves, Jessica Baka, Felipe Tavares Rodrigues","doi":"10.1159/000541672","DOIUrl":"10.1159/000541672","url":null,"abstract":"<p><strong>Introduction: </strong>Direct mycological examination and culture are the gold standard methods for diagnosing tinea capitis (Tc) despite 4-6 weeks of culture time. Meanwhile, specific trichoscopy patterns may be helpful in its diagnosis.</p><p><strong>Methods: </strong>This retrospective, cross-sectional, observational study included 31 patients among 110 records from children with presumable clinical and trichoscopic Tc diagnosis, from two dermopediatrics centers, within 10 years. After trichoscopy, skin scraping from the patients was taken for direct mycological examination with 10% KOH and cultures in Sabouraud and Mycosel media; patients with positive cultures for <i>M. canis</i> and <i>T. tonsurans</i> were selected. The association between the trichoscopic and etiological findings of Tc was statistically evaluated using Fisher's exact test.</p><p><strong>Results: </strong>Some trichoscopy findings, such as perifollicular desquamation and broken hair, were nonspecific to determine the Tc agent. The presence of Morse code (barcode-like) whitish sheath was more common in <i>M. canis</i> infection, even in the small number of patients of our sample. In contrast, comma hairs and black dots were more common in <i>T. tonsurans</i> infection.</p><p><strong>Conclusion: </strong>The trichoscopy findings suggest the pathophysiology of tinea infection according to the type of parasitism: ectothrix or endothrix and can be a useful tool where there are limited facilities.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"128-134"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Review of Misinformation on Alopecia. 关于脱发错误信息的定性综述。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-05 DOI: 10.1159/000541809
Paula Finnegan, YiXuan Goh, Michelle Murphy, Cathal O'Connor
{"title":"A Qualitative Review of Misinformation on Alopecia.","authors":"Paula Finnegan, YiXuan Goh, Michelle Murphy, Cathal O'Connor","doi":"10.1159/000541809","DOIUrl":"10.1159/000541809","url":null,"abstract":"<p><strong>Background: </strong>Alopecia is common and can lead to significant distress for patients. Patients often seek medical information on the Internet, which may leave them susceptible to misinformation from poor-quality sources. The aim of this study was to qualitatively assess misinformation available online related to alopecia.</p><p><strong>Summary: </strong>Several alopecia-related myths were identified, including false causes, criticism of conventional treatments, and bogus \"natural\" cures or remedies. False causes included headwear, haircare practices, and sexual practices. Treatments which were criticized included minoxidil, finasteride, topical corticosteroids, ciclosporin, methotrexate, and Janus kinase inhibitors. Alternative unfounded therapies which were touted included mineral supplements, biotin, B vitamin complexes, fish oils, shark cartilage, onion juice, rosemary oil, horsetail extract, and saw palmetto.</p><p><strong>Key messages: </strong>Misinformation related to alopecia is prevalent online and may lead to suboptimal therapeutic outcomes. Dermatologists and other healthcare professionals should combat misinformation when encountered.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"182-185"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Methotrexate Microinfusion in Scalp Lesions of Patients with Frontal Fibrosing Alopecia: A Prospective Controlled Trial. 甲氨蝶呤微量输注治疗额叶纤维化性脱发患者头皮病变的疗效:一项前瞻性对照试验。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-09-10 DOI: 10.1159/000540846
Tatiane Elen de Souza Pitlovanciv, Thelma Larocca Skare, Karina Bittencourt Medeiros, Andréa Buosi Fabri
{"title":"Efficacy of Methotrexate Microinfusion in Scalp Lesions of Patients with Frontal Fibrosing Alopecia: A Prospective Controlled Trial.","authors":"Tatiane Elen de Souza Pitlovanciv, Thelma Larocca Skare, Karina Bittencourt Medeiros, Andréa Buosi Fabri","doi":"10.1159/000540846","DOIUrl":"10.1159/000540846","url":null,"abstract":"<p><strong>Introduction: </strong>Topical and systemic drugs, as methotrexate (MTX), do not control the frontal fibrosing alopecia (FFA) activity in most of the cases showing the need for new therapies. Therefore, we aimed to evaluate the effectiveness of MTX microinfusion in FFA.</p><p><strong>Methods: </strong>Prospective, controlled clinical trial, carried out with 17 volunteers with clinical and histological diagnosis of FFA. Applications of MTX by MMP<sup>®</sup> (microinfusion of drugs into the skin method) were made every 30 days, in a total of 03 applications, in the right half of the alopecia area; the other half served as a control.</p><p><strong>Results: </strong>There was a significant reduction in frontal-glabella and frontal temporoparietal measurements at treated site while in the untreated site the FFA increased. Patient's referred improvement of pruritus and desquamation but not in hair loss and local erythema. Analysis of the dermoscopic photos and the LPPAI calculation did not show relevant changes. About 95% of the participants were satisfied or very satisfied with the results and none of them had alteration in the laboratory test results.</p><p><strong>Conclusion: </strong>The MTX application by MMP<sup>®</sup> improved symptoms associated with FFA, and the frontal-glabella and frontal temporoparietal measurements. This technique proved to be safe and well tolerated.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"151-158"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concomitant Allergic Contact Dermatitis and Frontal Fibrosing Alopecia: A Potential Trigger for Relapse or Onset? 伴发过敏性接触性皮炎和额部纤维性脱发:复发或发病的潜在诱因?
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-24 DOI: 10.1159/000541604
Andrea Sechi, Angelo Valerio Marzano, Anna Belloni-Fortina, Anna Zambello
{"title":"Concomitant Allergic Contact Dermatitis and Frontal Fibrosing Alopecia: A Potential Trigger for Relapse or Onset?","authors":"Andrea Sechi, Angelo Valerio Marzano, Anna Belloni-Fortina, Anna Zambello","doi":"10.1159/000541604","DOIUrl":"10.1159/000541604","url":null,"abstract":"<p><strong>Introduction: </strong>Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia predominantly affecting postmenopausal women, with histopathological similarities to lichen planopilaris but distinct clinical features. The global rise in FFA cases over the past 15 years points to potential environmental factors.</p><p><strong>Case presentation: </strong>This study presents 2 FFA cases: one experiencing a flare-up and another with disease onset, both associated with allergic contact dermatitis. Case 1 involved a 58-year-old female with a flare-up linked to a nickel allergy, while case 2 described a 60-year-old female with new-onset FFA following exposure to hair dye allergens.</p><p><strong>Discussion: </strong>Environmental particles, such as titanium dioxide found on hair shafts of FFA patients, are hypothesized to contribute to FFA through photocatalytic activity causing tissue damage and inflammation. Studies indicate a higher use of facial moisturizers and sunscreens among FFA patients, with frequent positive patch test reactions to allergens in personal care products. These allergens may disrupt hair follicle immune privilege, leading to inflammation, fibrosis, and follicular destruction. Understanding the role of environmental factors in FFA pathogenesis may improve management strategies, emphasizing allergen avoidance and targeted treatments.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"198-201"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients. 斑秃患者肠道游离脂肪酸结合蛋白4的测定。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-03 DOI: 10.1159/000541111
A E Soliman, Olfat Shaker, Samar M El-Tahlawi, Ghada Abdaltwab Mahgoub, Sara M Yaseen
{"title":"Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients.","authors":"A E Soliman, Olfat Shaker, Samar M El-Tahlawi, Ghada Abdaltwab Mahgoub, Sara M Yaseen","doi":"10.1159/000541111","DOIUrl":"10.1159/000541111","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an immune-mediated disease characterized by non-scaring hair loss. High levels of FABP4 have been implicated in different inflammatory diseases. We aim to assess and correlate the level of FABP4 in AA patients and compare with healthy controls.</p><p><strong>Methods: </strong>Eighty-Eight subjects enrolled subdivided equally into AA and healthy controls. AA patients were classified according to the severity and pattern of the disease. The concentration level of FABP4 in serum was assessed and compared to healthy controls using ELISA.</p><p><strong>Results: </strong>The level of FABP4 tends to increase in AA patients than controls with a significant difference (<i>p</i> = 0.0001).There were no statistically significant differences between FABP4 and gender, history, family history, related diseases, or prior treatments. There is a high significant difference between patients with relapse and progressive patients with <i>p</i> = 0.037. Also patients with positive effects in other body sites have higher FABP4 levels than patients without infection in other sites with <i>p</i> = 0.05. The level of FABP4 tends to increase with the severity of the patients. Findings show that there are positive correlations between FABP4 and (disease duration; number of attacks; SALT Score) with <i>r</i> = 0.45, <i>p</i> = 0.0021; <i>r</i> = 0.41, <i>p</i> = 0.007, and <i>r</i> = 0.88, <i>p</i> < 0.0001, respectively.</p><p><strong>Conclusion: </strong>Elevation of FABP4 in serum may correlate with disease severity and could play a vital role in the diagnosis of AA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"112-118"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopic Evaluation of Nail Changes in Patients with End-Stage Renal Disease on Regular Hemodialysis. 皮肤镜下对定期血液透析的终末期肾病患者指甲变化的评价。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-09-09 DOI: 10.1159/000539924
Sara A Galal, Hend G Kotb, Radwa O M Kamel, Hala M Elsadek, Hala S A Hafiz, Eman M Nassef, Sammar A Kasim, Samah M Akab, Ahmed S Abdel Sattar, Laila A Ahmed
{"title":"Dermoscopic Evaluation of Nail Changes in Patients with End-Stage Renal Disease on Regular Hemodialysis.","authors":"Sara A Galal, Hend G Kotb, Radwa O M Kamel, Hala M Elsadek, Hala S A Hafiz, Eman M Nassef, Sammar A Kasim, Samah M Akab, Ahmed S Abdel Sattar, Laila A Ahmed","doi":"10.1159/000539924","DOIUrl":"10.1159/000539924","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic renal failure can impact various body systems, including the skin and its appendages. Patients with uremic conditions have been observed to experience a variety of nail changes. This study was conducted to evaluate the presence and type of fingernail changes in patients with end-stage renal failure (ESRF) on regular hemodialysis (HD) by nail dermoscopy.</p><p><strong>Methods: </strong>A total of 100 patients with ESRF on regular HD three times a week. Nails were examined by dermoscopy for the presence of subtle nail changes.</p><p><strong>Results: </strong>Nail changes were found in 91% of patients, while 9% did not have nail changes. The most common dermoscopic findings were as follows; scales in lateral nail fold in 91% of the patients, dry cuticle in 84%, onychoschizia in 72%, and longitudinal striation in 69%. There was no significant relation between nail changes and sex, duration of HD, and albumin level.</p><p><strong>Conclusion: </strong>Patients with end-stage renal disease on HD are more likely to experience nail disorders. Scales in LNF, dry cuticle, onychoschizia, longitudinal striation, terry's nails, and half-and-half nails were the most common nail changes in HD patients.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"103-111"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease - an All of Us Study. 甲沟炎:从皮肤科角度看潜在的全身性疾病--我们所有人的研究。
IF 1.4
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-05 DOI: 10.1159/000542382
Noelle Desir, Shari R Lipner
{"title":"Nail Clubbing: A Dermatologic Window into Underlying Systemic Disease - an All of Us Study.","authors":"Noelle Desir, Shari R Lipner","doi":"10.1159/000542382","DOIUrl":"10.1159/000542382","url":null,"abstract":"<p><strong>Introduction: </strong>Nail clubbing is defined as distal phalanx thickening resulting in a bulbous appearance of the digit. We aimed to describe non-pulmonary medical conditions associated with nail clubbing using a cross-sectional approach.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of the All of Us Research Program, identifying nail clubbing patients by <i>ICD-10-CM</i> and/or <i>SNOMED</i> code. Nail clubbing patients with pulmonary disease (cases) were compared to nail clubbing patients without pulmonary disease (controls). Fisher's exact test/Pearson's χ<sup>2</sup> test analyzed categorical variables. Independent two-sample <i>t</i> tests analyzed continuous variables. Odds ratios (ORs) were analyzed with multivariate logistic regression adjusted for sociodemographic characteristics.</p><p><strong>Results: </strong>In total, 85 participants had nail clubbing, of which 63.53% had a pulmonary disease versus 36.47% of controls. Overall, across both cases and controls, 22% of patients had chronic liver disease, 17% hypothyroidism, 8% HIV infection, and 5% Graves' disease/hyperthyroidism. Male versus female patients with nail clubbing had decreased odds of having concurrent respiratory disease diagnosis (OR, 0.37; 95% CI, 0.14-0.92, <i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>Greater than one-third of patients had nail clubbing associated with a non-pulmonary systemic disease, and a significant proportion were male. Consideration of a broad differential of pathologies associated with nail clubbing is needed to initiate workup and make appropriate screening referrals.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 2","pages":"186-191"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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