Skin Appendage Disorders最新文献_第7页

Pigmented Desmoplastic Trichilemmoma Arising in Nevus Sebaceous: A Potential Mimicker of Pigmented Basal Cell Carcinoma. 皮脂腺痣中出现的色素脱鳞屑性三毛瘤：色素性基底细胞癌的潜在模仿者

IF 1.4

Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-13 DOI: 10.1159/000530001

Meshal M Alhameedy, Omar A Alrobaish, Sulaiman Almarshoud, Rand Albahli

引用次数: 0

Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature. 指甲鳞状细胞癌伴有瘤状特征：病例报告和文献综述。

IF 1.4

Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-14 DOI: 10.1159/000529906

Kelita Waterton, Cynthia M Magro, Shari R Lipner

{"title":"Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature.","authors":"Kelita Waterton, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000529906","DOIUrl":"10.1159/000529906","url":null,"abstract":"Introduction: Onycholemmal carcinoma (OC) is a rare subtype of squamous cell carcinoma (SCC) that originates from the epithelium of the nail bed. It is characterized by distinct histopathologic features including small clusters of atypical squamous epithelium devoid of a granular layer, with abrupt onycholemmal keratinization.Case presentation: We present a case of a 75-year-old male with right thumbnail onycholysis, yellow-green nail plate discoloration, as well as bleeding and purulence of the lateral nail fold. Histopathologic evaluation revealed high-grade squamous dysplasia, small clusters of severely atypical epithelial cells, and a pattern of abrupt keratinization consistent with the diagnosis of SCC carcinoma with onycholemmal features. GMS and PAS staining indicated concomitant onychomycosis. Pathologic analysis also disclosed residual SCC and concomitant amyloidosis, possibly light chain related and hence reflective of his underlying multi-organ lymphoplasmacytic lymphoma. The patient subsequently underwent Mohs micrographic surgery.Conclusion: Clinical presentation of nail unit SCC with onycholemmal features is highly variable, making differentiating between similarly presenting benign and malignant nail disorders particularly challenging. This case report demonstrates clinical and histopathological features of nail unit SCC with onycholemmal features to improve diagnosis and management.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"284-290"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on Chemical Peels for Nail Surface Rejuvenation. 化学换肤用于指甲表面年轻化的综述。

IF 1.4

Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-06-08 DOI: 10.1159/000530629

Wilhelmina Lam, Antonella Tosti

{"title":"Review on Chemical Peels for Nail Surface Rejuvenation.","authors":"Wilhelmina Lam, Antonella Tosti","doi":"10.1159/000530629","DOIUrl":"10.1159/000530629","url":null,"abstract":"Introduction: Superficial nail plate abnormalities are a potential consequence of harsh cosmetic manicures and also manifest as a symptom of nail diseases such as nail lichen planus, nail psoriasis, and onychomycosis. Chemical peels for the nails may provide a solution to improve nail appearance. We reviewed articles that assessed the efficacy of using chemical peels for the nails.Methods: Searches on PubMed were performed to identify studies that discussed the use of chemical peels on the nail published up to July 2022.Results: A total of 4 studies with a total of 96 patients were found involving the use of chemical peels for the nail. It was found that there was marked improvement in aesthetic appearance for nail surface abnormalities induced by cosmetics.Discussion/conclusion: Studies with larger sample sizes that compare the efficacy of doses, treatment length, and a standardized method to assess results are needed to determine best treatment protocol. Chemical peels for the nails may provide fast improvement of the appearance of the nail and be utilized as a supportive treatment in association with specific treatment.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"237-240"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9979014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program. 侏儒症与皮肤病和血管病有关：我们所有人研究计划的病例对照研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-04-20 DOI: 10.1159/000530096

Zi-Ning Choo, Shari R Lipner

引用次数: 0

Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit. 指甲部位盘状红斑狼疮引发的鳞状细胞癌

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-15 DOI: 10.1159/000529360

Tatiana Mina Yendo, Tatiana Villas Boas Gabbi, Marcello Menta Simonsen Nico

引用次数: 0

Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa. 血清淀粉样蛋白 A：化脓性扁平湿疹严重程度的潜在新标志物

IF 1.4

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-02-20 DOI: 10.1159/000528658

Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini

{"title":"Serum Amyloid A: A Potential New Marker of Severity in Hidradenitis Suppurativa.","authors":"Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini","doi":"10.1159/000528658","DOIUrl":"10.1159/000528658","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic inflammation and high impact on quality of life. Treatment strategies are still inadequate with a lack of inflammation biomarkers. We conducted a prospective study to assess the correlation between serum amyloid A (SAA) levels and active lesion count; disease severity; Dermatology Life Quality Index (DLQI); smoking; BMI; and lesion sites.Methods: Forty-one patients (M/F: 22/19) were enrolled. Demographic, clinical, laboratory, and therapeutic data were assessed at baseline on patients not under treatment or in wash-out from systemic treatment for at least 2 weeks. Associations were investigated by univariate and multivariate analyses.Results: SAA levels were significantly associated with number of nodules (p = 0.005), abscesses (p < 0.001), fistulas (p = 0.016), and severe IHS4 (p = 0.088 and r = 0.514). Gluteal localization was correlated with high values of mSartorius and severe IHS4.Conclusions: We recommend assessment of SAA levels to monitor therapeutic response in patient with HS in order to prevent disease's flare and potential complications.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"165-168"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series of Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution: Is There a Familial Correlation? 额部纤维性脱发和花纹分布的纤维性脱发病例系列：是否存在家族相关性？

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-30 DOI: 10.1159/000529923

Maria Fernanda Reis Gavazzoni Dias, Amanda Lofeu Cury, Enoi Aparecida Guedes Vilar, Patricia Guimarães Peixoto, Chloe Ekelem

引用次数: 0

Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features. 阿达木单抗诱发的银屑病性脱发和矛盾性银屑病可使用赛妥珠单抗成功治疗：临床、三镜和体内反射共聚焦显微镜特征。

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2022-12-08 DOI: 10.1159/000527985

Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza

{"title":"Psoriatic Alopecia and Paradoxical Psoriasis Induced by Adalimumab Successfully Treated with Certolizumab: Clinical, Trichoscopic, and in vivo Reflectance Confocal Microscopy Features.","authors":"Matteo Megna, Mario De Lucia, Lucia Gallo, Wanda Lauro, Vincenzo Picone, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza","doi":"10.1159/000527985","DOIUrl":"10.1159/000527985","url":null,"abstract":"Introduction: Psoriatic alopecia is considered a type of hair loss occurring in patients with psoriasis. Adalimumab is a fully humanized recombinant anti-TNF-alpha monoclonal antibody approved for treatment of psoriasis and psoriatic arthritis (PsA), rarely related to the occurrence of dermatological disorders.Case presentation: We report the case of a 56-year-old female with PsA developing psoriatic alopecia and paradoxical psoriasis induced by adalimumab and successfully treated switching to certolizumab, evaluating response at both thrichoscopy and in vivo reflectance confocal microscopy.Discussion: Among anti-TNF-α agents, certolizumab is the least involved in the development of paradoxical reactions such as psoriatic alopecia and showed to be an effective and safe alternative therapeutic options to manage psoriasis and PsA minimizing the risk of paradoxical reactions.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"207-210"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Infection in Hidradenitis Suppurativa Patients: A Retrospective Study. 化脓性汗腺炎患者COVID-19感染的回顾性研究

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 DOI: 10.1159/000529462

Devea R De, Jonathan W Rick, Terri Shih, Jennifer L Hsiao, Iltefat Hamzavi, Vivian Y Shi

{"title":"COVID-19 Infection in Hidradenitis Suppurativa Patients: A Retrospective Study.","authors":"Devea R De, Jonathan W Rick, Terri Shih, Jennifer L Hsiao, Iltefat Hamzavi, Vivian Y Shi","doi":"10.1159/000529462","DOIUrl":"https://doi.org/10.1159/000529462","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) is associated with comorbidities that are risk factors for severe COVID-19 infection. We evaluated demographics and COVID-19 outcomes in HS patients.Methods: HS patients with COVID-19 (HS+/COVID+) and a randomized age-, race-, and sex-matched control population of patients without HS with COVID-19 (HS-/COVID+) were selected through a retrospective chart review. Data were collected on demographics, medications, comorbidities, vaccination status, and COVID-19 treatment/outcomes. Fisher's exact test was used to analyze the relationship between risk factors and COVID-19 outcomes. A p value of <0.05 was considered statistically significant.Results: There were 58 HS+/COVID+ patients, primarily African American (83%, n = 48) and female (88%, n = 51). Compared to HS+/COVID+ patients, HS-/COVID+ patients were significantly more likely to have cardiovascular disease (51% vs. 24%; p = 0.0029) and be pregnant (23% vs. 4%; p = 0.0093). HS+/COVID+ and HS-/COVID+ patients did not vary significantly in vaccination rate at time of COVID-19 diagnosis (6% vs. 5%; p = 0.78). HS-/COVID+ patients were significantly more likely to have COVID-19 complications (35% vs. 7%; p = 0.001) and receive COVID-19 treatment (37% vs. 7%; p = 0.0001) when compared to HS+/COVID+ patients.Conclusion: Our findings support the growing evidence that having HS itself may not be a risk factor for severe COVID-19 outcomes.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"203-206"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alopecia Areata Barbae in a Nutshell. 毛囊性脱发简述

IF 1

Skin Appendage Disorders Pub Date : 2023-06-01 Epub Date: 2023-03-08 DOI: 10.1159/000529389

Adaeze Nwosu, Mariya Miteva

{"title":"Alopecia Areata Barbae in a Nutshell.","authors":"Adaeze Nwosu, Mariya Miteva","doi":"10.1159/000529389","DOIUrl":"10.1159/000529389","url":null,"abstract":"Beard alopecia areata, or alopecia areata barbae, (BAA) is a subset of alopecia areata, a T-cell mediated inflammatory disease that disrupts the hair follicle cycle leading to early onset of catagen. The aim of this review is to help strengthen clinicians' skills in the evaluation, diagnosis, and management of BAA. We performed a literature review according to the modified PRISMA guidelines, using a combination of relevant key words in electronic databases. According to the data from the 25 articles on BAA reviewed here, BAA mostly affects middle-aged men (mean age 31 years) who typically experience patchy hair loss in the neck region, which spreads to the scalp within 12 months. Similar to AA, BAA is associated with autoimmune diseases such as H. pylori and thyroiditis; however, BAA has no clear genetic pattern of inheritance which is observed in alopecia areata. Common dermoscopic findings in BAA include vellus white hairs and exclamation mark hairs, which may help distinguish it from other pathologies affecting facial hair. In clinical trials, the ALBAS tool offers clinicians an objective metric to evaluate BAA severity. Until recently, topical steroids have been the mainstay therapy; however, topical and oral janus kinase inhibitors are achieving improved results, with up to 75% beard regrowth in an average of 12 months.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 3","pages":"179-186"},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0