Skin Appendage Disorders最新文献_第7页

Scalp Microinfusion with Dutasteride Using the MMP® Technique for Male Androgenetic Alopecia: A 12-Month Real-World Observational Case Series. 使用MMP®技术头皮微滴杜他雄胺治疗男性雄激素性脱发：12个月真实世界观察病例系列。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-05 DOI: 10.1159/000550858

Nicolò Rivetti

{"title":"Scalp Microinfusion with Dutasteride Using the MMP® Technique for Male Androgenetic Alopecia: A 12-Month Real-World Observational Case Series.","authors":"Nicolò Rivetti","doi":"10.1159/000550858","DOIUrl":"10.1159/000550858","url":null,"abstract":"Introduction: Microinfusion of drugs into the skin (MMP®) is an intradermal drug delivery technique combining microneedling with controlled microinfusion using professional tattoo devices. In androgenetic alopecia (AGA), MMP has been proposed to enhance local follicular drug exposure while potentially minimizing systemic absorption, although evidence remains limited.Methods: Thirty male patients (20-45 years) with AGA (Hamilton-Norwood stages I-IV) were treated in strict monotherapy with scalp microinfusion of dutasteride 0.05%. Treatments were performed using a rotary tattoo device with sterile 49-needle cartridges (0.30-mm diameter), delivering 1 mL per session at a depth of 1.0 mm. Four monthly sessions were followed by bimonthly maintenance. Outcomes were assessed using physician global assessment, standardized photography, and patient self-assessment over 12 months.Results: At 12 months, stabilization or improvement was observed in 96.7% of patients, with clinical improvement in 76.7%. Patient-reported improvement occurred in 80.0%. Responses were more consistent in early to intermediate AGA. Treatment was well tolerated, with only mild transient local reactions.Conclusion: Scalp microinfusion with dutasteride using MMP® appears to be a safe and promising adjunctive treatment for male AGA. Further controlled studies are needed.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13021238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Series of Eosinophilic Pustular Folliculitis with Exclusive Scalp and Facial Involvement: A Distinct Entity? 仅累及头皮和面部的嗜酸性脓疱性毛囊炎病例系列：一个独特的实体？

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-02 DOI: 10.1159/000550808

İlayda Muslu Camcıoğlu, Ceyda Tetik Aydoğdu, Aslan Yürekli, Suzan Demir Pektaş, Emine Tuğba Alataş, Dilek Daşgın, Havva Solak Özşeker

{"title":"Case Series of Eosinophilic Pustular Folliculitis with Exclusive Scalp and Facial Involvement: A Distinct Entity?","authors":"İlayda Muslu Camcıoğlu, Ceyda Tetik Aydoğdu, Aslan Yürekli, Suzan Demir Pektaş, Emine Tuğba Alataş, Dilek Daşgın, Havva Solak Özşeker","doi":"10.1159/000550808","DOIUrl":"10.1159/000550808","url":null,"abstract":"Introduction: Eosinophilic pustular folliculitis (EPF) is a rare, non-infectious dermatosis characterized by pruritic, recurrent episodes of follicular papulopustules. Three main forms have been described: classic EPF (Ofuji disease), immunosuppression- or HIV-associated EPF, and infantile EPF. Histopathologically, eosinophilic infiltration within and around the follicular epithelium is a typical finding.Case presentation: We report four non-infant patients with negative anti-HIV antibody results who presented with pruritic follicular papulopustules exclusively involving the scalp and face. Histopathological examination in all cases confirmed the diagnosis of EPF.Conclusion: This case series highlights a clinical presentation of EPF with isolated scalp and facial involvement in immunocompetent adults. Although longer follow-up is required, these findings may suggest a distinct clinical pattern within the spectrum of EPF.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Episodes of Keratitis during Treatment with Baricitinib for Alopecia Areata. Baricitinib治疗斑秃期间角膜炎发作。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-03-28 DOI: 10.1159/000544920

Dorottya Godor, Anastasia Therianou

引用次数: 0

Racial Disparities in Healthcare Resource Utilization among Patients with Hidradenitis Suppurativa: An All of Us Database Analysis. 化脓性汗腺炎患者医疗资源利用的种族差异：一个我们所有人的数据库分析。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-11 DOI: 10.1159/000547793

Lauren Fleshner, Mehmet Fatih Atak, Katie Roster, Banu Farabi

{"title":"Racial Disparities in Healthcare Resource Utilization among Patients with Hidradenitis Suppurativa: An All of Us Database Analysis.","authors":"Lauren Fleshner, Mehmet Fatih Atak, Katie Roster, Banu Farabi","doi":"10.1159/000547793","DOIUrl":"10.1159/000547793","url":null,"abstract":"Introduction: Hidradenitis suppurativa (HS) disproportionately affects historically underrepresented populations, with social determinants of health (SDoH) contributing to disparities in access to care, specialty services, and medication access. This study aimed to evaluate healthcare utilization in HS, stratified by race, to better understand the role of SDoH.Methods: A cross-sectional analysis using the All of Us database was conducted using variables including surgical procedures, healthcare utilization, biologic use, and pertinent comorbidities (diabetes, obesity, smoking, sepsis). Survey data assessed socioeconomic factors and healthcare access. Chi-square tests were used (p < 0.005); analyses were performed in RStudio 4.1.2.Results: Among 2,265 patients with HS (40.26% African American, 77.48% female), African American patients had higher rates of emergency department visits, diabetes, complex surgeries, and inability to afford medications (all p < 0.01). White patients had more outpatient visits and delays in care due to anxiety (p < 0.0005 and p < 0.026, respectively).Conclusions: Racial disparities in HS healthcare utilization reflect the impact of SDoH, with African American patients experiencing greater disease burden. Early identification of high-risk patients and targeted interventions are essential to promote equitable care.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"50-54"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hair Loss Treatments: A Google Trends Analysis Worldwide of the Past 5 Years (2018-2023). 脱发治疗：过去5年全球趋势分析（2018-2023）

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-07-17 DOI: 10.1159/000547418

Lidiya Todorova, Nicolas Kluger

{"title":"Hair Loss Treatments: A Google Trends Analysis Worldwide of the Past 5 Years (2018-2023).","authors":"Lidiya Todorova, Nicolas Kluger","doi":"10.1159/000547418","DOIUrl":"10.1159/000547418","url":null,"abstract":"Introduction: We aimed to evaluate the recent trends in public interest regarding various alopecia-related treatments using Google Trends (GT).Method: Data generated through GT for the relative search volumes (RSVs) of the treatments-related terms were analysed: \"hair loss treatment\"; \"minoxidil\"; \"oral minoxidil\"; \"finasteride\"; \"dutasteride\"; \"hair transplant.\" Analysis has been performed worldwide from July 29, 2018, to July 16, 2023.Results: Mean RSVs for \"hair loss treatment\" have increased since 2021 (23 ± 2.8 in 2018 to 70 ± 7.5 in 2023). Interest in \"minoxidil\" has been growing since 2018, with \"minoxidil oral treatment\" gaining attention since 2021. \"Finasteride\" saw a rise in 2021; \"dutasteride\" experienced consistent growth. RSVs for \"hair transplant\" have remained stable. Geographically, public interest in \"hair loss treatment\" was concentrated in Middle Eastern countries and Japan. Interest in oral treatments was prominent in Latin American and Spanish-speaking countries; Ireland and the UK showed strong focus on hair transplants.Conclusion: GT is not a real epidemiological tool and can be only used by individuals who have access to the Internet. We observed temporal and geographical variations in public interest in hair loss treatments. COVID-19 pandemic, differences in the prevalence of alopecia-related conditions, cultural, social influences impact search trends across countries.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"12 1","pages":"46-49"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Clinicopathologic Subungual Angiokeratoma Series Demonstrating Clinical Features Mimicking Nail Unit Melanoma. 新型临床病理的甲下血管角化瘤系列表现出类似指甲单位黑色素瘤的临床特征。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-14 DOI: 10.1159/000547969

Elen Deng, Meaghan C Dougher, Julia O Baltz, Nathaniel J Jellinek, Adam I Rubin, Kimberly M Ken

{"title":"Novel Clinicopathologic Subungual Angiokeratoma Series Demonstrating Clinical Features Mimicking Nail Unit Melanoma.","authors":"Elen Deng, Meaghan C Dougher, Julia O Baltz, Nathaniel J Jellinek, Adam I Rubin, Kimberly M Ken","doi":"10.1159/000547969","DOIUrl":"10.1159/000547969","url":null,"abstract":"Introduction: Angiokeratomas are benign vascular tumors that typically present as a hyperkeratotic, red-brown to black papule on the lower extremities. Angiokeratomas in the subungual location are rare, with few reported cases in the literature.Case presentation: We present three biopsy-proven cases of subungual angiokeratomas with novel clinical features: involvement of the nail bed, clinically mimicking nodular melanoma, and involving a broad age range, with the youngest patient reported at 25 years old. Symptoms included tenderness and bleeding, while the clinical presentations ranged from evenly to irregularly pigmented nodule(s). Histopathology revealed morphologic findings; characteristics of angiokeratoma include multiple dilated vascular spaces within the superficial dermis and overlying epidermal hyperplasia.Conclusion: This case series expands the known clinical presentations of nail unit angiokeratomas and emphasizes the importance of including subungual angiokeratoma in the differential diagnosis of pigmented, nodular lesions of the nail unit.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"75-80"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of a Nail Cadaver Lab as a Teaching Tool for Dermatology Residents. 指甲尸体实验室作为皮肤科住院医师教学工具的效果。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-18 DOI: 10.1159/000548023

Christian Bailey-Burke, Jennifer Panara, Guanlin Guo, Lorrie Schmid, Jane Bellet, Erin Lesesky

{"title":"Efficacy of a Nail Cadaver Lab as a Teaching Tool for Dermatology Residents.","authors":"Christian Bailey-Burke, Jennifer Panara, Guanlin Guo, Lorrie Schmid, Jane Bellet, Erin Lesesky","doi":"10.1159/000548023","DOIUrl":"10.1159/000548023","url":null,"abstract":"Introduction: Instruction in nail procedures is limited in dermatology residency programs. Cadaveric-based educational sessions can help bridge the gap in nail procedure knowledge and confidence in residency education. This study evaluates a combined didactic and hands-on cadaveric workshop for two cohorts of second- and third-year dermatology residents at a single institution (2023 and 2025).Methods: Second- and third-year dermatology residents completed a pre-survey prior to the session to assess their comfort and confidence with nail procedures prior to completing a didactic nail surgery lecture and subsequent nail procedure cadaveric training. Participants completed a post-survey within a week after the nail cadaver lab training to re-assess their experience and confidence.Results: Participants demonstrated significant post-intervention improvements in comfort with nail procedures, including instruments needed to perform nail procedures, postoperative care, nail matrix biopsies, and nail avulsions, with confidence in complete and partial nail avulsions doubling. All residents endorsed the session's effectiveness and recommended repeating it for future dermatology residents.Conclusion: These findings highlight nail procedure cadaveric training as a reproducible, scalable intervention to address gaps in procedural dermatology education and enhance residents' skills in nail surgery.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"17-21"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety. 局部他克莫司、氯倍他索和米诺地尔治疗原发性瘢痕性脱发：临床结果和安全性的回顾性分析。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-22 DOI: 10.1159/000548130

Anna L Brinks, Caitlin A Kearney, Carli D Needle, Akshay Pulavarty, Archie Spindler, Derek Maas, Loren D Krueger, Kristen I Lo Sicco, Jerry Shapiro

{"title":"Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety.","authors":"Anna L Brinks, Caitlin A Kearney, Carli D Needle, Akshay Pulavarty, Archie Spindler, Derek Maas, Loren D Krueger, Kristen I Lo Sicco, Jerry Shapiro","doi":"10.1159/000548130","DOIUrl":"10.1159/000548130","url":null,"abstract":"Introduction: Primary cicatricial alopecias (PCAs) cause permanent hair loss and psychosocial distress. Management involves anti-inflammatory and hair growth-promoting therapies. A combination of tacrolimus, clobetasol, and minoxidil (TCM) may offer synergistic benefits by targeting distinct inflammatory pathways while increasing background hair density for improved camouflage. This study evaluates the safety and efficacy of TCM use in PCA patients.Methods: We conducted a retrospective chart review of PCA patients aged 18+ years treated with TCM between January 1, 2009, and May 31, 2025. Outcomes included inflammatory activity on trichoscopy, scalp symptoms, provider- and patient-reported disease status, and objective hair measurements. Descriptive statistics were performed using SAS v9.4.Results: Eighty-two patients (80.5% female, mean age 61.5) were included, most commonly with frontal fibrosing alopecia or lichen planopilaris. TCM was typically prescribed as a compounded solution used 1-2 times/day for an average of 24.5 months. Adverse effects included worsened itch/burning (6.1%), hypertrichosis (4.9%), scalp irritation/dryness (4.8%), and atrophy (3.7%); most (62.2%) experienced no adverse effects. Provider-assessed inflammation and disease status improved or stabilized in 69.5% and 76.9%, respectively. Objective hair measurements also improved.Conclusions: TCM is well tolerated and, used alone or in conjunction with other therapies, appears to be effective. Improvements were seen in provider-reported outcomes and objective hair measurements.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"55-59"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichonodosis: A Case Report and Literature Review. 滴虫病：1例报告及文献复习。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-16 DOI: 10.1159/000547816

Pattarada Chantanakul, Chinmanat Lekhavat

引用次数: 0

An Unusual Compulsive Behavior Related to Scalp Psoriasis and Hair Follicle Anxiety in Young Men. 一种与年轻男性头皮牛皮癣和毛囊焦虑相关的异常强迫行为。

IF 1.3

Skin Appendage Disorders Pub Date : 2026-02-01 Epub Date: 2025-08-14 DOI: 10.1159/000547907

Ramon Grimalt

{"title":"An Unusual Compulsive Behavior Related to Scalp Psoriasis and Hair Follicle Anxiety in Young Men.","authors":"Ramon Grimalt","doi":"10.1159/000547907","DOIUrl":"10.1159/000547907","url":null,"abstract":"Introduction: Patients suffering from androgenetic alopecia may experience obsessive behaviors on observing their own scalp.Case presentation: This article describes a series of three cases of young men presenting with an unusual, seemingly compulsive behavior related to mild scalp psoriasis and a family history of androgenetic alopecia. Contrary to the typical goal of psoriasis treatment, these patients exhibit an intense fixation on scalp scales containing embedded hairs. They actively avoid dislodging these scales during routine hygiene or therapeutic efforts, fearing that their removal might accelerate hair loss. The cases involve young men (aged 24, 19, and 22) with significant anxiety about hair loss, which manifests as a meticulous and repetitive manipulation of their scalps to preserve these specific scales.Conclusion: This behavior may fall within the spectrum of body-focused repetitive behaviors. This observation underscores the importance for dermatologists to thoroughly question patients about underlying anxieties and specific scalp manipulation behaviors, especially in young men with a familial history of alopecia, to facilitate more effective clinical management.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"8-11"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0