Evaluation of the Environmental Risk Factors and Comorbidities in Patients with Lichen Planopilaris: A Case-Control Study.

IF 1.4 Q3 DERMATOLOGY
Skin Appendage Disorders Pub Date : 2025-04-01 Epub Date: 2024-10-11 DOI:10.1159/000541295
Fahimeh Mahmoudi, Hamideh Moravvej, Soheila Nasiri, Elnaz Pourgholi, Atousa Yazdanshenas, Sahar Dadkhahfar
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Abstract

Introduction: Lichen planopilaris (LPP) is an uncommon cicatricial alopecia clinically characterized by follicular hyperkeratosis, perifollicular erythema, and permanent hair loss. The association of LPP with certain underlying diseases and environmental factors has been evaluated but there are limited data about this association. This study was designated to evaluate the environmental risk factors and comorbidities in LPP patients.

Method: This case-control study was performed on LPP patients referred to two dermatology referral centers from 2019 to 2022. A group of non-LPP healthy individuals referring for cosmetic concerns was recruited as control group. Data collection was performed using two questionnaires: a general questionnaire, including demographic information, comorbidities, environmental risk factors, and disease-related information, and the lichen planopilaris activity index (LPPAI) questionnaire.

Results: One hundred LPP patients as case group were compared with 100 healthy people without LPP as control group. Unemployment, history of major stressful events, thyroid disorder, history of hair dyeing, using face soaps, taking supplements, postmenopausal status, and family history of LPP or other types of alopecia had significant relationship with LPP (all p values <0.05).

Conclusion: LPP has associations with environmental and non-environmental risk factors and, also, genetic component.

评估扁平苔藓患者的环境风险因素和合并症:病例对照研究
扁平毛癣(LPP)是一种罕见的瘢痕性脱发,临床表现为毛囊角化过度、毛囊周围红斑和永久性脱发。LPP与某些潜在疾病和环境因素的关系已被评估,但有关这种关系的数据有限。本研究旨在评估LPP患者的环境危险因素和合并症。方法:选取2019 - 2022年在两家皮肤科转诊中心转诊的LPP患者进行病例对照研究。招募一组非lpp健康个体作为对照组。数据收集采用两份问卷进行:一份是普通问卷,包括人口统计信息、合并症、环境危险因素和疾病相关信息;另一份是扁平苔藓活动指数(LPPAI)问卷。结果:100例LPP患者为病例组,100例健康无LPP者为对照组。失业、重大压力事件史、甲状腺疾病、染发史、使用面皂、服用补充剂、绝经后状态、LPP家族史或其他类型脱发与LPP有显著关系(p值均为p值)。结论:LPP与环境和非环境危险因素有关,也与遗传因素有关。
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
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