Relative Effects of Minoxidil 5%, Platelet-Rich Plasma, and Microneedling in Pattern Hair Loss: A Systematic Review and Network Meta-Analysis

IF 1.4 Q3 DERMATOLOGY
Aditya K. Gupta, Tong Wang, Mary A. Bamimore, Shruthi Polla Ravi, Mesbah Talukder
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Abstract

Background: Combination treatments may improve the utility of approved agents for the treatment of pattern hair loss (PHL); however, head-to-head comparisons are lacking. Objective: The aim of the study was to compare the efficacy of 5% minoxidil, platelet-rich plasma (PRP), and microneedling across adults with PHL insofar as change in total hair density at 24 weeks. Methods: We conducted a literature search in July 2022. Through our Bayesian network meta-analysis, we estimated treatments’ surface under the cumulative ranking distribution (SUCRA) values and relative effects – in terms of mean difference (MD). Results: Data from 27 trials, totaling 1,110 patients, were extracted. Interventions were ranked based on the probability of inducing hair density improvements: 5% minoxidil plus microneedling (SUCRA = 95.8%), 5% minoxidil plus PRP (SUCRA = 64.7%), 5% minoxidil (SUCRA = 53.9%), PRP (SUCRA = 34.9%), microneedling (SUCRA = 27.8%), and PRP with microneedling (SUCRA = 22.9%). The efficacy of 5% minoxidil plus microneedling in improving total hair density was significantly greater (p &lt; 0.05) than 5% minoxidil monotherapy (MD = 13 hairs/cm2), PRP monotherapy (MD = 16 hairs/cm2), and microneedling monotherapy (MD = 17 hairs/cm2). Conclusion: Five percent minoxidil plus microneedling is an effective treatment option for improving hair density at 6 months in adult PHL patients.
米诺地尔5%、富血小板血浆和微针治疗型脱发的相对作用:一项系统综述和网络meta分析
& lt; b> & lt; i>背景:& lt; / i> & lt; / b>联合治疗可以提高批准的药物治疗型脱发(PHL)的效用;然而,缺乏面对面的比较。& lt; b> & lt; i>目的:& lt; / i> & lt; / b>该研究的目的是比较5%米诺地尔、富血小板血浆(PRP)和微针治疗在24周时对PHL成人总发密度的影响。& lt; b> & lt; i>方法:& lt; / i> & lt; / b>我们在2022年7月进行了文献检索。通过贝叶斯网络元分析,我们估计了处理在累积排名分布(SUCRA)值下的表面和相对效应-以平均差(MD)表示。& lt; b> & lt; i>结果:& lt; / i> & lt; / b>从27项试验中提取数据,共计1110例患者。根据诱导发密度改善的概率对干预措施进行排序:5%米诺地尔加微针(SUCRA = 95.8%)、5%米诺地尔加PRP (SUCRA = 64.7%)、5%米诺地尔(SUCRA = 53.9%)、PRP (SUCRA = 34.9%)、微针(SUCRA = 27.8%)、PRP加微针(SUCRA = 22.9%)。5%米诺地尔加微针改善总发密度的效果显著更大(<i>p</i>, lt;0.05)比米诺地尔单药治疗(MD = 13毛/cm<sup>2</sup>)、PRP单药治疗(MD = 16毛/cm<sup>2</sup>)、微针单药治疗(MD = 17毛/cm<sup>2</sup>)高出5%。& lt; b> & lt; i>结论:& lt; / i> & lt; / b>5%米诺地尔加微针是改善成年PHL患者6个月时头发密度的有效治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
10.00%
发文量
69
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