Skin Appendage Disorders最新文献

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Use of Hydroxychloroquine in Hair Disorders 羟氯喹在头发疾病中的应用
Skin Appendage Disorders Pub Date : 2023-09-19 DOI: 10.1159/000533583
Advaitaa Ravipati, Michael Randolph, Waleed Al-Salhi, Antonella Tosti
{"title":"Use of Hydroxychloroquine in Hair Disorders","authors":"Advaitaa Ravipati, Michael Randolph, Waleed Al-Salhi, Antonella Tosti","doi":"10.1159/000533583","DOIUrl":"https://doi.org/10.1159/000533583","url":null,"abstract":"Hydroxychloroquine (HCQ) is an antimalarial that is utilized to treat a range of dermatologic and autoimmune disorders. With its ability to alter immunologic mechanisms, it has been used to slow or halt the progression of hair loss in conditions secondary to autoimmune dysfunction. Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and alopecia areata (AA) are hair disorders with underlying autoimmune components and no standardized treatment guidelines. We summarized the available literature on the use of HCQ to treat LPP, FFA, and AA. For all three conditions, HCQ showed variable efficacy from halted hair loss to no improvement. While patients did show success with HCQ treatment, there were no clear treatment patterns. Regimens ranged from HCQ monotherapy to combination treatments with other agents like steroids. Overall, HCQ should certainly be considered by clinicians as a treatment option for patient suffering from these hair disorders. While there is no standardized treatment, incorporation of HCQ should take into consideration individual patient characteristics, clinical judgment, and risks of side effects.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135109712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Atypical Presentation of Spitz Nevus: A Case Report 斯皮兹痣的非典型表现:1例报告
Skin Appendage Disorders Pub Date : 2023-09-06 DOI: 10.1159/000533385
Isabel Araiza-Atanacio, Andrea Venegas-Andrade, Sonia Toussaint-Caire, Carolina Palacios López
{"title":"Atypical Presentation of Spitz Nevus: A Case Report","authors":"Isabel Araiza-Atanacio, Andrea Venegas-Andrade, Sonia Toussaint-Caire, Carolina Palacios López","doi":"10.1159/000533385","DOIUrl":"https://doi.org/10.1159/000533385","url":null,"abstract":"<b><i>Introduction:</i></b> The Spitz nevus (SN) is an acquired melanocytic neoplasm composed of epithelioid and/or spindle cells, which tends to develop in childhood. In pediatric patients, it is usually located on the face and neck. Unusual locations have been found in the literature, such as the penis, mouth, and tongue, as well as 2 cases of ungual SN. <b><i>Case Report:</i></b> A 15-year-old male evaluated for dark brown-black longitudinal melanonychia that covered 40% of the nail, with pseudo-Hutchinson’s sign, of 1 year of evolution. <b><i>Discussion:</i></b> The SN accounts for 1% of the melanocytic neoplasms. In the present paper, we show the third case of ungual SN never previously disclosed, which presents a zigzag pattern reported in the literature for its association with the pediatric population.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plica Neuropathica in 2 Hispanic Patients 2例西班牙裔患者的皱襞神经病
Skin Appendage Disorders Pub Date : 2023-09-06 DOI: 10.1159/000531938
Daniel Asz-Sigall, César Ramos-Cavazos, Paulina Mariel Gay-Muñoz, Jessica González-Gutiérrez, Alejandra Guerrero-Álvarez, Eduardo Corona-Rodarte
{"title":"Plica Neuropathica in 2 Hispanic Patients","authors":"Daniel Asz-Sigall, César Ramos-Cavazos, Paulina Mariel Gay-Muñoz, Jessica González-Gutiérrez, Alejandra Guerrero-Álvarez, Eduardo Corona-Rodarte","doi":"10.1159/000531938","DOIUrl":"https://doi.org/10.1159/000531938","url":null,"abstract":"<b><i>Introduction:</i></b> Plica neuropathica (PN) is a rare, acquired, and irreversible condition characterized by the formation of a compacted mass of tangled hair held together by a hard keratin cement. <b><i>Case Presentation:</i></b> In case 1, a 50-year-old woman with history of contact dermatitis of the scalp presented with hair tangling and difficulty combing. Physical examination revealed a matted mass of hair with a dirty appearance and non-scarring alopecia. Case 2 involved a 46-year-old woman who experienced spontaneous hair matting after using various products, resulting in a dreadlock-like appearance. Clinical examination showed a compact and matted mass of hair with irregular twists, dirt, and yellowish exudate. <b><i>Conclusion:</i></b> PN’s exact pathogenesis is not fully understood, but it is believed to involve physical and chemical insults to the hair shaft. Risk factors include self-neglect, hair felting or rubbing, certain substances, religious practices, chemotherapy, immunosuppressive drugs, infections, and contact dermatitis. Trichoscopy can provide valuable clues for an accurate diagnosis, such as fractured hairs, bent hair shafts, trichorrhexis nodosa, retained telogen hairs, and twisted hairs. Treatment involves cutting the matted hair, and early-stage manual separation may be beneficial.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"V 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Truth or Trend – Misinformation Spreading Fast on TikTok: A Cross-Sectional Analysis of Onychomycosis Content 真相还是趋势——在TikTok上快速传播的错误信息:对甲真菌病内容的横断面分析
Skin Appendage Disorders Pub Date : 2023-09-01 DOI: 10.1159/000533319
Kelita A. Waterton, Shari R. Lipner
{"title":"Truth or Trend – Misinformation Spreading Fast on TikTok: A Cross-Sectional Analysis of Onychomycosis Content","authors":"Kelita A. Waterton, Shari R. Lipner","doi":"10.1159/000533319","DOIUrl":"https://doi.org/10.1159/000533319","url":null,"abstract":"<b><i>Background:</i></b> Onychomycosis is the most frequently diagnosed nail condition in clinical practice. With the growing popularity of TikTok and online health information-seeking behavior, it is imperative to understand onychomycosis-related content on this platform. <b><i>Objective:</i></b> Our objective was to assess content and quality of the most popular onychomycosis-related content on TikTok. <b><i>Methods:</i></b> We queried TikTok for videos using the search terms “onychomycosis” and “nail fungus” for the top 100 videos by view count, with DISCERN scoring used to rate videos for quality. <b><i>Results:</i></b> Average DISCERN score was 1.77 and dermatologists posted videos with the highest mean score (2.56). Most of the videos were educational (72%) and/or related to treatment (69%). Home remedies were recommended more often (58%) than FDA-approved therapies (7%). Physician versus nonphysician posted videos had higher mean DISCERN score (2.28 vs. 1.44) (<i>p &amp;lt;</i> 0.001), greater view number (1,209,953 vs. 343,993) (<i>p</i> &amp;lt; 0.05), and more often discussed medical therapy (<i>p</i> &amp;lt; 0.05). <b><i>Conclusion:</i></b> While social media is a valuable resource for providing medical information to an interminable audience, there are significant shortcomings. Therefore, we recommend that dermatologists advise patients against relying on social media for medical information and consider using social media to provide accessible evidence-based health education on onychomycosis.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135688177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaposi Sarcoma of the Nail Unit: A Case Report and Review of the Literature 甲部卡波西肉瘤1例报告及文献复习
Skin Appendage Disorders Pub Date : 2023-08-23 DOI: 10.1159/000532114
Jonathan Krygier, Ursula Sass, Isabelle Meiers, Alice Marneffe, Marine de Vicq de Cumptich, Bertrand Richert
{"title":"Kaposi Sarcoma of the Nail Unit: A Case Report and Review of the Literature","authors":"Jonathan Krygier, Ursula Sass, Isabelle Meiers, Alice Marneffe, Marine de Vicq de Cumptich, Bertrand Richert","doi":"10.1159/000532114","DOIUrl":"https://doi.org/10.1159/000532114","url":null,"abstract":"<b><i>Introduction:</i></b> Kaposi sarcoma is an angioproliferative neoplasm. Its manifestations are well known but nail involvement seems extremely underreported. <b><i>Case Presentation:</i></b> A 55-year-old man presented with a 6-month history of a growing subungual tumor affecting the third right toe. After surgical excision, histological examination revealed a Kaposi sarcoma. <b><i>Discussion:</i></b> We report a case of Kaposi sarcoma with nail involvement of only one toe as the first and unique manifestation, which is exceptional.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135620690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dasatinib-Induced Transverse Melanonychia 达沙替尼诱导的横向黑色素瘤
Skin Appendage Disorders Pub Date : 2023-08-21 DOI: 10.1159/000531928
Mehul Tyagi, Vishal Gaurav, Japnoor Kaur
{"title":"Dasatinib-Induced Transverse Melanonychia","authors":"Mehul Tyagi, Vishal Gaurav, Japnoor Kaur","doi":"10.1159/000531928","DOIUrl":"https://doi.org/10.1159/000531928","url":null,"abstract":"<b><i>Introduction:</i></b> Transverse melanonychia, characterized by grey to black pigmented bands traversing the nail plate, can occur as a side-effect of certain medications. While no documented reports specifically associate dasatinib, a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia, with nail changes, we present a case of transverse melanonychia possibly related to dasatinib therapy. <b><i>Case Report:</i></b> A 54-year-old male with CML, receiving dasatinib for 1.5 years, presented with transverse pigmented lines involving all fingernails and toenails. Clinical examination revealed discrete bands of transverse melanonychia in the nails. Onychoscopy of all finger- and toenails revealed multiple longitudinal grey lines within transverse grey bands of homogeneous chromonychia. Based on clinical presentation, onychoscopic features, and temporal association with dasatinib therapy, a provisional diagnosis of dasatinib-induced transverse melanonychia was made. <b><i>Discussion:</i></b> The exact mechanisms underlying melanonychia are not fully understood but may involve nail matrix or toxicity, stimulation of nail-matrix melanocytes, or drug deposition within the nail plate. This case highlights the possibility of dasatinib-induced transverse melanonychia and underscores the importance of monitoring and evaluating nail changes in patients undergoing dasatinib treatment.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135876585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Fluconazole-Induced Fixed Drug Eruption of the Digit with Nail Matrix Involvement: A Case Report and Review of the Literature 复发性氟康唑致累及甲基质的手指固定药疹1例报告及文献复习
Skin Appendage Disorders Pub Date : 2023-08-18 DOI: 10.1159/000532112
Loren E. Hernandez, Arvin Jadoo, Brian Morrison
{"title":"Recurrent Fluconazole-Induced Fixed Drug Eruption of the Digit with Nail Matrix Involvement: A Case Report and Review of the Literature","authors":"Loren E. Hernandez, Arvin Jadoo, Brian Morrison","doi":"10.1159/000532112","DOIUrl":"https://doi.org/10.1159/000532112","url":null,"abstract":"<b><i>Introduction:</i></b> Fixed drug eruptions (FDEs) are cutaneous hypersensitivity reactions due to an offending drug and are rarely associated with nail involvement. Moreover, FDEs associated with fluconazole use are sparsely reported in literature. <b><i>Case Presentation:</i></b> We report a case of a recurrent FDE with involvement of one finger and corresponding Beau’s lines due to fluconazole use. The diagnosis of FDE secondary to fluconazole use was confirmed histopathologically, with improvement after the application of twice daily 0.05% clobetasol propionate ointment. <b><i>Conclusion:</i></b> FDEs are hypersensitivity reactions that occur after exposure to an offending drug. FDEs uncommonly affect the nail matrix and are often not caused by fluconazole. It is important for dermatologists to assess for changes in the nail plate when evaluating a patient with FDE and evaluate all medications a patient is taking.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"441 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136214847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibro-Osseus Pseudotumor of the Digit: A Case Report and Review of Literature 手指纤维-骨假瘤1例报告及文献复习
Skin Appendage Disorders Pub Date : 2023-08-18 DOI: 10.1159/000532113
Chander Grover, Pratibha Gupta, Chhavi Gupta, Kaniyappan Nambiyar, Shitij Goel
{"title":"Fibro-Osseus Pseudotumor of the Digit: A Case Report and Review of Literature","authors":"Chander Grover, Pratibha Gupta, Chhavi Gupta, Kaniyappan Nambiyar, Shitij Goel","doi":"10.1159/000532113","DOIUrl":"https://doi.org/10.1159/000532113","url":null,"abstract":"<b><i>Introduction:</i></b> Bony subungual growths arising on the digital tip are uncommon. Among these, subungual exostosis is a common cause. <b><i>Case Presentation:</i></b> We describe a 35-year-old-male patient with a rare occurrence of a fibro-osseus pseudotumor of the digit. It presents with reactive intramembranous ossification, with no continuity with the distal phalanx, helping differentiate it from a subungual exostosis. The patient presented with an asymptomatic subungual growth, lifting up the nail plate distally causing onycholysis. The characteristic clinical, radiological, and histopathological features of the case are described, which helped confirm the diagnosis. <b><i>Conclusion:</i></b> Cases with fibro-osseus pseudotumor of the digit reported in literature are reviewed comprehensively. The factors helping differentiate this from the other bony tumors affecting the distal phalanx, including subungual exostosis, myositis ossificans, and osteosarcoma are also highlighted.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136214848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study 间苯二酚10%作为轻度化脓性汗腺炎的有希望的治疗选择:一项前瞻性、随机、开放研究
Skin Appendage Disorders Pub Date : 2023-08-16 DOI: 10.1159/000531926
Alexandros Katoulis, Ourania Efthymiou, Aikaterini Liakou, Georgia Pappa, Antonios Kanelleas, Dimitra Koumaki, Evangelia Bozi, Dimitrios Sgouros
{"title":"Resorcinol 10% as a Promising Therapeutic Option for Mild Hidradenitis Suppurativa: A Prospective, Randomized, Open Study","authors":"Alexandros Katoulis, Ourania Efthymiou, Aikaterini Liakou, Georgia Pappa, Antonios Kanelleas, Dimitra Koumaki, Evangelia Bozi, Dimitrios Sgouros","doi":"10.1159/000531926","DOIUrl":"https://doi.org/10.1159/000531926","url":null,"abstract":"<b><i>Introduction:</i></b> Treatment of hidradenitis suppurativa (HS) is challenging, and in Hurley stage I, it is based on topical measures. Our aim was to compare the efficacy and safety of topical resorcinol 10% with topical clindamycin 1% and no therapy, in Hurley stage I HS. <b><i>Methods:</i></b> In this open, prospective, randomized trial, we studied 60 Hurley stage I patients with IHS4 ≤10. Group A was treated with topical resorcinol 10%; group B with clindamycin lotion 1%; and group C received no treatment. Patients were evaluated by total lesion count, the International Hidradenitis Suppurativa Severity Score System (IHS4) and the Dermatology Life Quality Index (DLQI) at baseline, 12 and 24 weeks. Self-reported number of flares and adverse events (AEs) were recorded. <b><i>Results:</i></b> A significant reduction in the mean total lesion count and DLQI scores were observed in group A, compared to group B at week 12 (<i>p</i> = 0.036, <i>p</i> &amp;lt; 0.001, respectively), and in the mean total lesion count, IHS4, and DLQI scores at week 24 (<i>p</i> = 0.034, <i>p</i> = 0.017, <i>p</i> &amp;lt; 0.001, respectively). Resorcinol 10% was well-tolerated with only mild AEs. <b><i>Conclusion:</i></b> Resorcinol 10% may represent a useful alternative for the long-term treatment of mild HS, which is superior to topical clindamycin and has a favorable safety profile.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135021897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nail Unit Arteriovenous Hemangioma Presenting as Longitudinal Erythronychia. 甲单元动静脉血管瘤表现为纵向红斑。
IF 1.4
Skin Appendage Disorders Pub Date : 2023-08-01 Epub Date: 2023-06-16 DOI: 10.1159/000530739
Jonathan K Hwang, Cynthia M Magro, Shari R Lipner
{"title":"Nail Unit Arteriovenous Hemangioma Presenting as Longitudinal Erythronychia.","authors":"Jonathan K Hwang, Cynthia M Magro, Shari R Lipner","doi":"10.1159/000530739","DOIUrl":"10.1159/000530739","url":null,"abstract":"<p><strong>Introduction: </strong>Localized longitudinal erythronychia is defined as a single nail with a longitudinal red band extending the length of a nail plate. It has a broad differential of benign and malignant etiologies, and is rarely due to benign vascular proliferations.</p><p><strong>Case presentation: </strong>We present a unique case of nail unit arteriovenous hemangioma presenting as longitudinal erythronychia of the left thumbnail in a 76-year-old male. The band was 6 mm and encompassed over 40% of the surface area of the nail plate. Dermoscopy showed red bands that were regular in terms of color, but not thickness or spacing. Due to concern for an amelanotic melanoma, a longitudinal excision was performed. Histopathology was consistent with a diagnosis of nail unit arteriovenous hemangioma.</p><p><strong>Conclusion: </strong>Arteriovenous hemangiomas were rarely present in the nail unit. They can be present as a blue or red nodule/macule, or as longitudinal erythronychia. Diagnosis often requires an excisional biopsy, with histopathology notable for a proliferation of multiple thick- and thin-walled vascular structures lined by a flattened endothelium. Our case emphasizes the need to consider vascular proliferations, such as arteriovenous hemangioma, in the differential diagnosis of longitudinal erythronychia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"9 4","pages":"300-305"},"PeriodicalIF":1.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10019645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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