Skin Appendage Disorders最新文献_第5页

Non-Amputative Digit Preservation Surgery versus Amputation in Nail Unit Melanoma: A Retrospective Study in Mexico and Brazil. 指甲单位黑色素瘤的非截肢手指保留手术与截肢：墨西哥和巴西的回顾性研究。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000544995

Jorge Ocampo-Garza, Adriana G Peña-Romero, Eduardo Bertolli, Mayra A Reyes Soto, Nilton Gioia Di Chiacchio, Francisco A Belfort, Veronica Fonte-Avalos, Nilton Di Chiacchio, Judith Domínguez-Cherit

{"title":"Non-Amputative Digit Preservation Surgery versus Amputation in Nail Unit Melanoma: A Retrospective Study in Mexico and Brazil.","authors":"Jorge Ocampo-Garza, Adriana G Peña-Romero, Eduardo Bertolli, Mayra A Reyes Soto, Nilton Gioia Di Chiacchio, Francisco A Belfort, Veronica Fonte-Avalos, Nilton Di Chiacchio, Judith Domínguez-Cherit","doi":"10.1159/000544995","DOIUrl":"https://doi.org/10.1159/000544995","url":null,"abstract":"Introduction: Nail unit melanoma (NUM) is a rare but aggressive malignancy with historically poor outcomes. Currently, there are no treatment guidelines for NUM.Methods: A retrospective analysis was conducted on patients diagnosed with NUM in Mexico and Brazil. Clinical and histopathological data were reviewed, and outcomes were compared between those who underwent amputation versus digit preservation surgery. Survival rates, recurrence, and functional status were assessed.Results: A total of 75 patients from Mexico (51.9%) and Brazil (48.1%) were evaluated. Clinical and pathological characteristics were similar between both groups. Functional surgery was performed in 40 patients (49.4%), including six with invasive melanomas. The median follow-up was 50.3 months (95% CI: 29.4-71.3, SE: 10.7). Among the 7 patients with invasive melanomas who underwent functional surgery, one experienced a recurrence, and one died from a cerebrovascular accident. The remaining 5 patients are alive and disease-free, with follow-up periods ranging from 1 to 27 months.Conclusions: Non-amputative surgery may be a safe alternative for thin NUMs, reducing amputation-related morbidity. Long-term follow-up and larger studies are needed to confirm guidelines.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatological Comorbidities Accompanying Rosacea and Their Relationship with Clinical and Demographic Features, Quality of Life, and Systemic Comorbidities: A Retrospective, Case-Controlled, Multicenter Survey. 伴随酒渣鼻的皮肤病合并症及其与临床和人口学特征、生活质量和全身合并症的关系：一项回顾性、病例对照、多中心调查。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000545295

Berna Aksoy, Elif Yıldırım, Ezgi Aktaş, Mualla Polat, Kıymet Handan Kelekci, Mustafa Tosun, Aysun Sikar Aktürk, Ilkin Zindancı, Seniz Duygulu, Emine Çölgeçen, Zehra Asiran Serdar, Ömer Kutlu, Neslihan Fişek İzci, Ayşe Serap Karadağ

{"title":"Dermatological Comorbidities Accompanying Rosacea and Their Relationship with Clinical and Demographic Features, Quality of Life, and Systemic Comorbidities: A Retrospective, Case-Controlled, Multicenter Survey.","authors":"Berna Aksoy, Elif Yıldırım, Ezgi Aktaş, Mualla Polat, Kıymet Handan Kelekci, Mustafa Tosun, Aysun Sikar Aktürk, Ilkin Zindancı, Seniz Duygulu, Emine Çölgeçen, Zehra Asiran Serdar, Ömer Kutlu, Neslihan Fişek İzci, Ayşe Serap Karadağ","doi":"10.1159/000545295","DOIUrl":"https://doi.org/10.1159/000545295","url":null,"abstract":"Introduction: As rosacea patients are generally light-skinned and photosensitized some sun-related skin findings are likely to be observed. This study aimed to determine which dermatological comorbidities accompany rosacea and evaluate their relationship with clinical, demographic, quality-of-life, and systemic comorbidities.Methods: This case-control multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Patient demographics, clinical findings, lifestyle data, medical history, and dermatological comorbidities were collected using a structured physician-administered questionnaire. All patients completed the Dermatology Life Quality Index.Results: The study included 922 rosacea patients and 799 controls without rosacea. Rosacea patients had higher dermatological comorbidities than controls. The prevalence of skin comorbidities increased as patient age and duration of rosacea increased. Additionally, these skin comorbidities negatively affected quality of life. Some dermatological comorbidities, especially civatte poikiloderma, had strongest predictive risk (odds ratio ⫺3) of significant systemic comorbidities.Conclusion: Based on the present findings, clinicians should also assess rosacea patients for cutaneous dermatological comorbidities. Presence of skin comorbidities increased as patient age and duration of rosacea increased and might be predictive of systemic comorbidities.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scarring Alopecia and Risk of Skin Cancer: A Literature Review. 瘢痕性脱发与皮肤癌风险：文献综述。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-20 DOI: 10.1159/000545345

Juwon Lee, Ludovica de Gregorio, Antonella Tosti

{"title":"Scarring Alopecia and Risk of Skin Cancer: A Literature Review.","authors":"Juwon Lee, Ludovica de Gregorio, Antonella Tosti","doi":"10.1159/000545345","DOIUrl":"https://doi.org/10.1159/000545345","url":null,"abstract":"Background: Primary scarring alopecia is characterized by irreversible hair follicle destruction and chronic inflammation, which may create a microenvironment conducive to skin cancer development. Non-melanoma skin cancers (NMSCs), such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), are influenced by factors like UV exposure and prolonged inflammation. The link between primary scarring alopecia and increased scalp skin cancer risk remains unclear.Summary: This review analyzed thirteen studies reporting NMSC in primary scarring alopecia subtypes, including lichen planopilaris, discoid lupus erythematosus, folliculitis decalvans, and erosive pustular dermatosis of the scalp. Chronic inflammation, UV exposure, and immunosuppressive therapies were identified as potential contributors to malignancy.Key messages: Primary scarring alopecia may increase susceptibility to SCC and BCC, particularly in areas of prolonged inflammation or immunosuppression. Clinicians should emphasize sun protection, routine follow-up, and patient education to minimize risk and improve outcomes. Further research is needed to clarify these associations.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Selenium Disulfide-Based Shampoo Is Beneficial for Dandruff Management and Rebalancing the Scalp Microbiome of Subjects of Any Hair Type. 含二硫化硒的洗发水对任何发质的头皮屑管理和头皮微生物群的平衡都有好处。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-03-11 DOI: 10.1159/000544742

Pascal Edouard Reygagne, Claire Deloche-Bensmaine, Stephanie Leclerc-Mercier, Julie Faure, Natalia Kovylkina, Cecile Clavaud, Audrey Gueniche, Victoria Barbosa

{"title":"A Selenium Disulfide-Based Shampoo Is Beneficial for Dandruff Management and Rebalancing the Scalp Microbiome of Subjects of Any Hair Type.","authors":"Pascal Edouard Reygagne, Claire Deloche-Bensmaine, Stephanie Leclerc-Mercier, Julie Faure, Natalia Kovylkina, Cecile Clavaud, Audrey Gueniche, Victoria Barbosa","doi":"10.1159/000544742","DOIUrl":"10.1159/000544742","url":null,"abstract":"Introduction: Dandruff is a chronic scalp condition occurring in all hair types. Selenium disulfide (SeS2) shampoo is beneficial in dandruff and rebalances the scalp microbiome. However, data regarding subjects with curly hair are missing. This study assessed the clinical and scalp microbiome benefits of SeS2 shampoo in subjects of any hair type with moderate-to-severe dandruff.Methods: A 6-week study in adult subjects of any De La Mettrie hair type (I-VIII) assessed total dandruff, SD severity score (SSSD), erythema, hair greasiness, quality of life, discomfort, local tolerance, perceived benefit, acceptability, cosmeticity, and changes in the scalp microbiota. SeS2 shampoo was applied twice every week.Results: Overall, 93 subjects of any hair type (women: 83%, hair types: I-III: 41%, IV-V: 29%, VI-VIII: 30%) were recruited. 69% were of European and 31% of African origin. SSSD and total dandruff scores were the highest in hair type IV-V, erythema scores in hair type I-III, and the itching score in hair type VI-VIII, with no differences between hair types for any parameter. After 4 weeks, clinical signs and subject assessments had significantly (all p < 0.05) decreased in all phototypes. SeS2 shampoo significantly (p < 0.001) rebalanced the scalp microbiome. All subjects highly appreciated its benefit, acceptability, and cosmeticity. SeS2 shampoo was well tolerated.Conclusion: SeS2 shampoo is beneficial in moderate-to-severe dandruff and rebalances the scalp microbiota in all hair types. SeS2 shampoo was highly appreciated by the subjects for its benefit, acceptability, and cosmeticity, allowing a potential improvement of compliance, including in the long term.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Cell Tumor of Flexor Tendon Sheath: An Interesting Clinical Presentation as Subungual Growth. 屈肌腱鞘巨细胞瘤：一种有趣的临床表现为趾下生长。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-13 DOI: 10.1159/000540487

Chander Grover, Pratibha Gupta, Rajesh Arora, Pragya Jain

引用次数: 0

Hairbrushes: A Guide for Dermatologists. 发刷：皮肤科医生指南。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-12 DOI: 10.1159/000540486

Kimberly N Williams, Juwon Lee, Esthefani Robles, Antonella Tosti

引用次数: 0

Drug-Induced Hair Loss: Analysis of the Food and Drug Administration's Adverse Events Reporting System Database. 药物引起的脱发：食品和药物管理局不良事件报告系统数据库的分析。

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-07-29 DOI: 10.1159/000540104

Rachel C Hill, Steven D Zeldin, Shari R Lipner

{"title":"Drug-Induced Hair Loss: Analysis of the Food and Drug Administration's Adverse Events Reporting System Database.","authors":"Rachel C Hill, Steven D Zeldin, Shari R Lipner","doi":"10.1159/000540104","DOIUrl":"10.1159/000540104","url":null,"abstract":"Introduction: Drug-induced hair loss is one of several causes of hair loss commonly seen in clinical practice, and it is often a daunting task to determine a potential culprit drug when a patient is taking numerous medications. Our objective was to identify drugs responsible for hair loss, using the Food and Drug Administration's Adverse Events Reporting System (FAERS) database, a compilation of drug-related adverse events (AEs).Methods: Using the FAERS database, we queried all domestic reports with the reaction term \"alopecia\" listed as an AE in patients ≥18 years old from April 1, 1968, to September 29, 2023. Using descriptive statistics, individual agents were grouped by drug class.Results: We analyzed a total of 39,346 hair loss AE reports related to a single agent. Immunomodulatory agents and monoclonal antibodies represented the highest proportion of AE reports for alopecia, followed by hair loss drugs, contraceptives, and antitumor necrosis factor (anti-TNF) biologics.Conclusion: In sum, we showed that immunomodulatory agents and monoclonal antibodies, hair loss drugs, including minoxidil and finasteride, contraceptives, kinase inhibitors, and anti-TNF drugs are most frequently associated with hair loss AEs in the FAERS database. Because many of these drugs are not prescribed primarily for dermatologic indications, our study provides guidance for dermatologists in identifying common medications associated with alopecia.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"63-69"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Insights Malalignment or Retronychia: Which Comes First? 错位还是后甲：哪个先出现？

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-08 DOI: 10.1159/000540488

André Lencastre, Bertrand Richert

引用次数: 0

Patient Characteristics, Diagnostic Testing Utilization, and Antifungal Prescribing Pattern for Onychomycosis in the USA: A Cohort Study Using DataDerm, 2016-2022. 美国甲真菌病的患者特征、诊断测试使用和抗真菌处方模式：一项使用DataDerm的队列研究，2016-2022

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-29 DOI: 10.1159/000540704

Aditya K Gupta, Tong Wang, Anh N Tran

{"title":"Patient Characteristics, Diagnostic Testing Utilization, and Antifungal Prescribing Pattern for Onychomycosis in the USA: A Cohort Study Using DataDerm, 2016-2022.","authors":"Aditya K Gupta, Tong Wang, Anh N Tran","doi":"10.1159/000540704","DOIUrl":"10.1159/000540704","url":null,"abstract":"Introduction: Onychomycosis is a complex nail disease that is commonly seen in daily practice.Methods: Electronic health records of clinically diagnosed onychomycosis patients were extracted using DataDerm - a dermatology data registry hosted by the American Academy of Dermatology - spanning from the year 2016 to 2022.Results: Regardless of age, an increasing trend in patient volume was observed in the Southern US region, which accounted for 50.7-56.9% of onychomycosis patients in 2022. A coinfection of tinea pedis was present among 15.6-22.5% of patients. Diagnostic testing was infrequently utilized with less than one-quarter of patients having a histopathologic examination (12.7-21.9%) followed by fungal culture (5.5-8.2%) and direct microscopic examination (3.3-6.0%). Treatments were infrequently prescribed, accounting for less than one-quarter of patients (orals, terbinafine: 20.8-29.1%, fluconazole: 12.9-16.5%; topicals, efinaconazole: 3.2-13.8%); over 30% of treated patients received a combination regimen or experienced switching of treatments. Prescribing patterns did not significantly differ in vulnerable patient groups such as elderly patients and in patients with concomitant tinea pedis. Patients receiving a topical and/or oral antifungal prescription were frequently not tested to confirm the onychomycosis diagnosis (76.9%).Conclusion: Our findings add to a growing body of literature calling for the improvement of onychomycosis management practices.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 1","pages":"36-44"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sisaipho Revisited: Inverse Ophiasis or More than That? 再访西塞弗：反蛇病还是更严重？

IF 1.4

Skin Appendage Disorders Pub Date : 2025-02-01 Epub Date: 2024-08-12 DOI: 10.1159/000540489

Alexandros Katoulis, Georgia Pappa, Effie Markou, Antonios Kanelleas, Evangelia Bozi, Dimitrios Sgouros, Dimitris Rigopoulos, Lidia Rudnicka

引用次数: 0