Skin Appendage Disorders最新文献

{"title":"Hepatic Transaminases Evaluation in Patients with Onychomycosis Treated with Oral Antifungals: A Retrospective Study with 229 Patients.","authors":"Laiza Bertolucci Ferrero, Guilherme Camargo Julio Valinoto, Gustavo Carvalho, John Verrinder Veasey","doi":"10.1159/000548989","DOIUrl":"10.1159/000548989","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is the most common nail disorder in dermatology. Treatment can be challenging due to factors related to the pathogen and the patient's health status. Therapeutic options include topical and oral antifungals; while oral agents offer higher cure rates, they also present drawbacks such as prolonged treatment duration and potential adverse effects, with liver toxicity being the most frequently reported. Previous reviews highlight a scarcity of studies addressing the actual frequency of liver enzyme alterations during therapy.</p><p><strong>Methods: </strong>This retrospective study analyzed medical records from 313 patients treated at the Dermatology Clinic of a tertiary hospital. Changes in hepatic transaminases (aspartate aminotransferase, aspartate aminotransferase/TGO, and alanine aminotransferase, alanine aminotransferase/TGP) were evaluated in patients with a confirmed diagnosis of onychomycosis undergoing treatment with systemic antifungals.</p><p><strong>Results: </strong>Among 229 patients, 22 (9.6%) exhibited elevated hepatic transaminase levels. Oral antifungals demonstrated an overall favorable safety profile, with a low rate of transaminase elevation and no cases of hepatotoxicity. Patients with multiple comorbidities and concomitant medication use were more likely to present laboratory abnormalities, suggesting a possible cumulative effect on hepatic metabolism.</p><p><strong>Conclusion: </strong>In a real-world tertiary hospital setting, where most patients carried multiple comorbidities and were on continuous medications, oral antifungals for onychomycosis demonstrated a reassuring hepatic safety profile. The low incidence of enzyme alterations, all reversible after drug withdrawal, supports the continued use of systemic therapy in appropriately selected patients, reinforcing that comorbidities alone should not preclude oral antifungal treatment when clinically indicated.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"85-90"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report of Hair Abnormalities in Dyskeratosis Congenita: A Trichoscopic and Microscopic Analysis.","authors":"Mariem Tabka, Asmahane Souissi, Feriel Amri, Malek Mrad, Mourad Mokni","doi":"10.1159/000548845","DOIUrl":"10.1159/000548845","url":null,"abstract":"<p><strong>Introduction: </strong>Dyskeratosis congenita (DC) is a rare inherited telomere biology disorder characterized by mucocutaneous and systemic manifestations. There are limited descriptions of hair involvement.</p><p><strong>Case presentation: </strong>We present the case of a 19-year-old male from a consanguineous family, diagnosed with DC, who exhibited classical dermatological and hematological features, as well as distinctive trichoscopic findings, including scattered irregular black dots, pigtail hairs, S-shaped and zigzag hairs, and microscopic evidence of cuticular abnormalities, including ruffled surfaces, flat fractures, and trichoptilosis.</p><p><strong>Conclusion: </strong>This case highlights the under-recognized spectrum of hair pathology in DC, supporting the role of telomere dysfunction in impairing hair follicle homeostasis and structural integrity.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":"102-105"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoos and Hidradenitis Suppurativa: What the Dermatologist Should Know?","authors":"Nicolas Kluger","doi":"10.1159/000548642","DOIUrl":"10.1159/000548642","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by recurrent painful nodules, abscesses, and scarring, primarily affecting intertriginous areas. As tattoos have gained widespread popularity, individuals with HS may consider getting tattooed.</p><p><strong>Summary: </strong>Patients with HS are exposed to the same potential risks as the general population and they include the possibility of delayed healing, tattoo allergies, or infections. Additionally, future location of the tattoo and timing of the procedure need to be considered. While no extensive clinical studies specifically address the relationship between tattoos and HS, anecdotal reports suggest that individuals with well-controlled HS may tolerate tattoos in unaffected areas.</p><p><strong>Key-message: </strong>HS is not a contraindication for tattooing, but patients need proper guidance. Proper pre-tattoo consultation with dermatologists, careful site selection, tattooing by a professional artist in a tattoo parlor and strict aftercare protocols are essential to minimize complications.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"12 2","pages":"124-128"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Beneath the Nail Plate: A Case Report of Subungual Squamous Cell Carcinoma Mimicking Benign Nail Dystrophy.","authors":"Gökçe Işıl Kurmuş, Sedef Çakal Güngörür, Selin Çolak, Özay Gököz, Selda Pelin Kartal","doi":"10.1159/000548466","DOIUrl":"10.1159/000548466","url":null,"abstract":"<p><strong>Introduction: </strong>Subungual squamous cell carcinoma (SCC) is a rare malignancy often misdiagnosed due to its clinical resemblance to benign nail conditions.</p><p><strong>Case presentation: </strong>A 26-year-old male neurosurgeon presented with a 4-year history of isolated nail changes, including longitudinal erythronychia and distal splitting of the left fourth fingernail. Despite the absence of pain or mass, his occupational exposure to ionizing radiation and active tobacco use raised suspicion. Dermoscopy was inconclusive, and imaging ruled out bone involvement. Histopathological evaluation of the excised nail unit confirmed SCC in situ. The patient underwent complete nail unit excision with periosteal dissection, followed by flap reconstruction. At 4-month follow-up, he showed no signs of recurrence.</p><p><strong>Conclusion: </strong>This case underscores the need for early biopsy in persistent nail alterations, even among young patients, particularly when risk factors such as radiation exposure exist. Prompt histologic diagnosis allowed for timely, function-preserving surgical intervention.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"12 2","pages":"148-154"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Fibrosing Alopecia and Cyclines in Skin of Color Patients: A Retrospective Study of 50 Patients.","authors":"Zineb Loubaris, Rasha Moumna, Anas Ahmed Mountassir, Majdouline Obtel, Laila Benzekri, Mariame Meziane","doi":"10.1159/000548844","DOIUrl":"10.1159/000548844","url":null,"abstract":"<p><strong>Introduction: </strong>Frontal fibrosing alopecia (FFA) is a scarring alopecia that mainly affects women and is characterized by progressive frontal hairline recession and eyebrow loss. The efficacy of doxycycline in patients with skin of color remains underexplored. The objective of our study is to assess the clinical and dermoscopic response to doxycycline in patients with FFA and skin of color.</p><p><strong>Methods: </strong>A retrospective study was conducted over 4 years at Ibn Sina University Hospital, Rabat. Fifty female patients with FFA received oral doxycycline (100 mg/day) for at least 6 months. Disease patterns, associated conditions (lichen planus pigmentosus and rosacea), and treatment response were evaluated. Statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Median age was 52 years; 60% were postmenopausal. Linear FFA was most common (70%), and 46% had lichen planus pigmentosus. Doxycycline led to improvement in 57% of patients (<i>p</i> = 0.02), particularly in linear and pseudo-fringe patterns. Dermoscopic improvements included decreased perifollicular erythema and hyperkeratosis (<i>p</i> = 0.01). All patients with rosacea improved. Adverse events occurred in 16% of cases.</p><p><strong>Conclusion: </strong>Doxycycline appears effective and well-tolerated in managing FFA in patients with skin of color, especially in cases associated with lichen planus pigmentosus or rosacea.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"12 2","pages":"81-84"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychomycosis and Lifestyle: A Survey Study Correlating Patient Habits with Infection.","authors":"Kimia Targhi, Nicole Sangha, Katelyn Cornelius, Shoumi Sarkar, Divya Aickara, Brian Morrison","doi":"10.1159/000551602","DOIUrl":"https://doi.org/10.1159/000551602","url":null,"abstract":"<p><strong>Introduction: </strong>Onychomycosis is a common fungal infection of the nails, significantly impacting patients' quality of life and posing a public health concern due to its prevalence and treatment challenges. This study aimed to determine the association between specific lifestyle factors and the risk of developing toenail onychomycosis.</p><p><strong>Methods: </strong>This cross-sectional survey-based study was conducted from July 2023 to August 2023 and involved a sample of 202 patients aged 18 years or older. The survey assessed exposure to lifestyle factors including footwear habits, hygiene practices, and toenail care routines.</p><p><strong>Results: </strong>Of the 202 participants, 102 were clinically diagnosed with onychomycosis. Onychomycosis was associated with wearing closed-toe shoes (OR 1.71, 95% CI: 0.39-7.73, <i>p</i> = 0.78, Q = 0.73), walking barefoot in public areas (OR 4.77, 95% CI: 1.38-19.23, <i>p</i> = 0.02, Q = 0.07), and toenail trauma (OR 3.33, 95% CI: 1.41-8.28, <i>p</i> < 0.01, Q = 0.06). Protective factors included wearing clean socks (OR 0.07, 95% CI: 0.00-0.46, <i>p</i> = 0.02, Q = 0.07) and trimming nails regularly (OR 0.44, 95% CI: 0.13-1.48).</p><p><strong>Conclusion: </strong>This study identifies associations between certain lifestyle practices and onychomycosis. Educating patients on proper foot hygiene and footwear choices can help reduce the incidence of this condition. Further research is needed to explore additional preventive strategies.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of Monilethrix and Androgenetic Alopecia: A Case Report and Review of the Literature.","authors":"Emilee M Dreifus, Lyndsey M Slape, Elle Mariano, Betty Nguyen","doi":"10.1159/000551701","DOIUrl":"https://doi.org/10.1159/000551701","url":null,"abstract":"<p><strong>Introduction: </strong>Classic monilethrix is an autosomal dominant hair shaft disorder caused by heterozygous mutations in hair keratin genes, leading to childhood-onset hair fragility and perifollicular hyperkeratosis, most prominent on the occipital scalp.</p><p><strong>Case presentation: </strong>A 38-year-old woman with lifelong occipital hair fragility and inability to grow hair beyond short lengths presented with progressive frontal scalp thinning. Trichoscopy revealed hair shaft variability of numerous hair shafts, including miniaturized hairs showing alternating nodes and internodes consistent with monilethrix and androgenetic alopecia.</p><p><strong>Conclusion: </strong>This clinical case and review of the literature underlines that diagnosis and management of monilethrix can be more difficult when it is associated with other acquired hair conditions, such as androgenetic alopecia.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail Changes in Congenital Insensitivity to Pain with Anhidrosis: A Case Report.","authors":"Aysha Najeeb, Vishal Gaurav, Kaushal K Verma","doi":"10.1159/000551554","DOIUrl":"https://doi.org/10.1159/000551554","url":null,"abstract":"<p><strong>Introduction: </strong>Nail changes often reflect underlying systemic disease and may be the presenting manifestation of rare genetic disorders. Here, we report 2 siblings with congenital insensitivity to pain with anhidrosis (CIPA) with prominent nail findings.</p><p><strong>Case report: </strong>We report two brothers who presented with prominent nail abnormalities including dystrophy, brachyonychia, anonychia, paronychia, and pseudo-clubbing, along with acro-osteolysis of distal phalanges. Subsequent evaluation revealed insensitivity to pain and temperature, intellectual disability, recurrent fractures, self-mutilation, and anhidrosis, leading to a diagnosis of CIPA. Genetic analysis confirmed a novel homozygous <i>NTRK1</i> gene deletion.</p><p><strong>Conclusion: </strong>This report highlights the importance of nail manifestations as potential diagnostic indicators of CIPA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychological Impact of Frontal Fibrosing Alopecia in Men: A Multicenter Cross-Sectional Study.","authors":"Ana Melián-Olivera, Alejandro Lobato-Berezo, Angela Hermosa-Gelbard, Rocio Gil-Redondo, Alba Gómez-Zubiaur, Virginia Velasco-Tamariz, Andrea Combalia-Escudero, Francisco M Camacho-Martínez, Valentina Balaguera-Orjuela, Sergio Vañó-Galván, David Saceda-Corralo","doi":"10.1159/000551665","DOIUrl":"https://doi.org/10.1159/000551665","url":null,"abstract":"<p><strong>Introduction: </strong>Frontal fibrosing alopecia (FFA) is a scarring alopecia increasingly recognized in men, with potential psychological repercussions. This study aimed to assess the impact of FFA on men's quality of life (QoL).</p><p><strong>Methods: </strong>A multicenter cross-sectional study was conducted including men diagnosed with FFA who completed the Hair-Specific Skindex-29 (HSS29), Women's AGA Quality of Life Questionnaire (WAA-QoL), and Hospital Anxiety and Depression Scale (HADS). Associations were analyzed using Spearman's correlation, Kruskal-Wallis, and chi-square tests.</p><p><strong>Results: </strong>Eighty-one men (mean age 54.7 years) participated. Moderate to severe emotional impairment was present in 39.5% of patients, particularly in younger individuals and those with temporal hairline involvement. Mean HADS scores indicated mild psychological distress.</p><p><strong>Conclusion: </strong>FFA significantly affects men's QoL, especially younger patients, underscoring the need for psychosocial assessment regardless of disease severity. FFA is a type of scarring alopecia that is increasingly affecting men [J Am Acad Dermatol. 2022;86(2):481-484; J Am Acad Dermatol. 2014;70(4):670-678]. A negative impact on the emotional and psychological health of patients has been reported [JAMA Dermatol. 2018;154(4):479-480]. The aim of our study was to evaluate the impact of FFA on the QoL in men.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Serum Trace Elements and Telogen Effluvium: A Systematic Review and Meta-Analysis.","authors":"Azhar Ahmed, Azhar Alali, Mohammed Alahmadi, Sara Alghamdi, Zakaria Khawaji, Abdulsalam Humedi, Shaden Alqurashi","doi":"10.1159/000550921","DOIUrl":"https://doi.org/10.1159/000550921","url":null,"abstract":"<p><strong>Introduction: </strong>Telogen effluvium (TE) affects the scalp and is marked by widespread, non-scarring hair loss. This systematic review and meta-analysis aimed to evaluate the association between these micronutrients and TE across different age-groups.</p><p><strong>Methodology: </strong>Eligible studies included RCTs, clinical trials, cohort, case-control, and cross-sectional studies that reported serum levels of zinc, copper, or vitamin D in TE patients versus healthy controls. Meta-analyses were conducted using RevMan 5.3 with a random-effects model; heterogeneity was assessed via <i>I</i> ² and chi² statistics.</p><p><strong>Results: </strong>Out of 372 papers, 29 articles were considered suitable for the systematic review extracted through the database search. Diagnostic methods included trichoscopy and standardized assays (e.g., AAS, ICP-MS). This review analyzed TE patients as predominantly female. Meta-analyses revealed significantly lower serum ferritin (SMD = -0.57, 95% CI: -1.01 to -0.12, <i>p</i> = 0.01) and vitamin D (SMD = -0.87, 95% CI: -1.49 to -0.25, <i>p</i> = 0.006) levels in TE cases versus controls.</p><p><strong>Conclusion: </strong>TE is strongly associated with deficiencies in ferritin and vitamin D. Despite high heterogeneity, findings underscore the role of trace element imbalances in hair loss. Personalized nutritional interventions and standardized diagnostic protocols are recommended to address variability and improve clinical outcomes.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}