{"title":"Exploring Premature Greying of Hair: A Cross-Sectional Study on Prevalence, Psychological Effects, and Contributing Factors.","authors":"Arucha Treesirichod, Chainwit Dhanasarnsombat, Napat Thongsiri, Koraphat Thapanakulsak, Kamolnawin Chanthanumatt","doi":"10.1159/000543572","DOIUrl":"10.1159/000543572","url":null,"abstract":"<p><strong>Introduction: </strong>Premature greying of hair (PGH) is a cosmetic issue affecting youths, and limited research has been conducted on its prevalence and impact in the Thai population. This study aimed to investigate the prevalence, psychological impact, and associated factors of PGH.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with volunteering students aged 25 or younger from a Thai university. Participants completed a self-administered survey that included questions on PGH status, psychological effects, and associated factors, which include psychological stress, alcohol and cigarette consumption, body mass index, paternal and maternal history of PGH, exercise frequency, and diet.</p><p><strong>Results: </strong>A total of 441 participants were included in the analysis. The prevalence of PGH was 47.17%, with an average (sd) onset age of 16.29 (3.08) years. Self-assessment revealed hair greying <25% in 89.42% of all PGH cases. Of those with PGH, 67.31% reported no psychological impact, whilst 25.00% reported self-confidence loss, and 7.69% were bullied. PGH is found to be significantly associated with maternal and paternal history of the condition (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The results showed a high prevalence of PGH, with the majority of cases involving less than 25% hair greying and no psychological impact. PGH was found to be significantly associated with both maternal and paternal history.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"215-220"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alopecia: A Google Trends Analysis of the Past 5 Years (2018-2023).","authors":"Lidiya Todorova, Nicolas Kluger","doi":"10.1159/000541548","DOIUrl":"10.1159/000541548","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to evaluate recent trends in public interest regarding various alopecia-associated diagnoses using Google Trends.</p><p><strong>Method: </strong>Data generated through Google Trends for the relative search volumes (RSVs) of the following diagnostic-related terms: \"Alopecia,\" \"Alopecia areata,\" \"Androgenetic alopecia,\" \"Central centrifugal cicatricial alopecia,\" \"Folliculitis decalvans,\" \"Frontal fibrosing alopecia,\" \"Telogen effluvium,\" \"Traction alopecia\" (disease).\" Analysis has been performed worldwide from July 29th, 2018, to July 16th, 2023.</p><p><strong>Results: </strong>Between 2018 and 2023, mean RSVs by 12-month period have remained stable for \"alopecia\" and \"alopecia areata.\" \"Telogen effluvium\" has increased peak search during 2020-2022. \"Androgenetic alopecia\" and \"frontal fibrosing alopecia\" display an increase for the past 5 years. There were differences in geographic distribution. For alopecia areata, all the countries were from the Middle East; for telogen effluvium, eight of the top 10 countries were Latin American or Spanish speaking, and Western countries had mainly searched for frontal fibrosing alopecia.</p><p><strong>Conclusions: </strong>Google Trends is not a real epidemiological tool. It can be only used by individuals who have access to the Internet, but it does not presume the person or the reason for the search. We observed different geographical distribution according to the disease. Infodemiology provides a better understanding of alopecia needs in different countries and continents.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"282-286"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Singal, Nina Vijayvargiya, Naeha Pathak, Shari R Lipner
{"title":"Clinical Trials in Nail Psoriasis: Cross-Sectional Analysis of the Current State of Research.","authors":"Amit Singal, Nina Vijayvargiya, Naeha Pathak, Shari R Lipner","doi":"10.1159/000542568","DOIUrl":"10.1159/000542568","url":null,"abstract":"<p><strong>Introduction: </strong>Nail involvement occurs in approximately 90% of patients with cutaneous psoriasis and in isolation in 5%-10% of patients. There is an unmet need for diagnostic and therapeutic algorithms for nail psoriasis (NP), partially due to limited number of clinical trials.</p><p><strong>Methods: </strong>The ClinicalTrials.gov, the EU, the Australian New Zealand, and the World Health Organization International Clinical Trials Registries were queried for the term \"nail psoriasis\". Trial data characteristics were collected and analyzed.</p><p><strong>Results: </strong>A total of 112 clinical trials were included, with mean trial length 46.7 weeks and mean number of participants 272.7. Medications were most often studied in 97 (86.6%) trials, followed by lasers in 7 (6.3%) trials. NP Severity Index score was the most often studied outcome measure in 91 (84.3%) trials, and only 56 (52.8%) trials assessed adverse events. Only 3 (2.83%) trials included children, and many clinical trials excluded patients aged 65+ and 85+. Results were posted for 46 (41.4%) trials with mean participant age 45.1 years, mean percentage of females of 38.3%, and 87.8% of participants being White.</p><p><strong>Conclusion: </strong>Our findings highlight a need for clinical trials assessing efficacy and long-term therapeutic safety with a broad range of age-groups and increased representation of minorities and female patients.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"232-244"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li-Chi Chen, Chino Ogbutor, Kristen J Kelley, Maryanne M Senna
{"title":"Patient Considerations when Using Ritlecitinib for Alopecia Areata in Adolescents: Guidance for the Clinicians.","authors":"Li-Chi Chen, Chino Ogbutor, Kristen J Kelley, Maryanne M Senna","doi":"10.1159/000541392","DOIUrl":"10.1159/000541392","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss that can affect children, adolescents, and adults. Ritlecitinib, an orally administered Janus kinase (JAK) 3/tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family inhibitor, is the first and currently the only treatment approved by the US Food and Drug Administration for adolescents (aged 12-17 years) with severe AA.</p><p><strong>Summary: </strong>The ALLEGRO phase 2b-3 trial demonstrated that 25% and 50% of adolescents with a Severity of Alopecia Tool (SALT) score ≥50 at baseline achieved a SALT score ≤20 at week 24 and week 48 after receiving 50 mg ritlecitinib daily, respectively. The most common adverse events were headache, acne, and nasopharyngitis in adolescents. This review summarizes the mechanism of action, clinical trial evidence on efficacy and safety profile, factors associated with treatment response to JAK inhibitors for AA, and vaccination considerations for adolescents.</p><p><strong>Key messages: </strong>This review aims to facilitate the risk-benefit assessment and shared decision-making between clinicians and patients and provide clinical considerations and management recommendations for ritlecitinib use in adolescents with AA.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"262-269"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Asz-Sigall, Marysol Macedo Perez, Rosa María Lacy-Niebla, Carlos Barrera-Ochoa, Roberto Arenas, Sonia Toussaint-Caire, Diana Santamaría-Domínguez, Diana Valeria Guerrero-Hernández, Irene M Rodríguez-Escamilla, Eduardo Corona-Rodarte
{"title":"Alopecia Mimicking Lichen Planopilaris in a Patient with Mycosis Fungoides.","authors":"Daniel Asz-Sigall, Marysol Macedo Perez, Rosa María Lacy-Niebla, Carlos Barrera-Ochoa, Roberto Arenas, Sonia Toussaint-Caire, Diana Santamaría-Domínguez, Diana Valeria Guerrero-Hernández, Irene M Rodríguez-Escamilla, Eduardo Corona-Rodarte","doi":"10.1159/000543256","DOIUrl":"10.1159/000543256","url":null,"abstract":"<p><strong>Introduction: </strong>Mycosis fungoides (MF), the most common form of primary cutaneous T-cell lymphoma, can present with diverse clinical manifestations, including alopecia that mimics conditions such as alopecia areata (AA) and lichen planopilaris (LPP). The folliculotropic variant (FMF) poses diagnostic challenges due to overlapping clinical features, necessitating histopathological evaluation for accurate diagnosis.</p><p><strong>Case report: </strong>A 58-year-old woman with a 21-year history of stage IB MF developed alopecic patches in the left temporoparietal region, accompanied by pruritus and trichodynia. Physical examination revealed scarring and non-scarring alopecic patches, while trichoscopy showed characteristic features of follicular involvement. Histological analysis confirmed a diagnosis of FMF, characterized by atypical lymphocytic infiltrate and follicular destruction. Treatment included maintenance of NB-UVB and isotretinoin, with the addition of monthly intralesional corticosteroid injections, resulting in symptomatic improvement.</p><p><strong>Discussion/conclusion: </strong>This case highlights the diagnostic challenges posed by FMF mimicking AA and LPP. The overlap in clinical and trichoscopic findings underscores the necessity for histopathological evaluation to confirm FMF and differentiate it from other alopecic conditions. Early recognition and a multidisciplinary approach to treatment are crucial for improving outcomes in patients with this aggressive variant of MF.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"296-301"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skin and Bone: Chronic Paronychia Leading to Osteomyelitis.","authors":"Jonathan de Vries, Mimi Chung, Boni E Elewski","doi":"10.1159/000542607","DOIUrl":"10.1159/000542607","url":null,"abstract":"<p><strong>Introduction: </strong>Paronychia can be both acute and chronic dependent on the chronicity of disease, with different etiologies linked to each. Acute paronychia is commonly secondary to bacterial infections, while chronic paronychia can be multifactorial and include inflammatory causes.</p><p><strong>Case presentation: </strong>We present a case of chronic paronychia that developed into osteomyelitis of the affected finger.</p><p><strong>Conclusion: </strong>Because nail folds are anatomically close to the phalanges, it is important to monitor for worsening disease, as paronychia can develop into more serious infections.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"287-290"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Asz-Sigall, Alejandra Segarra-Ponce, Sofía Olvera-Lerma, Luis Enrique Cano-Aguilar, Eduardo Corona-Rodarte
{"title":"Red Scalp Disease: An Underdiagnosed Entity.","authors":"Daniel Asz-Sigall, Alejandra Segarra-Ponce, Sofía Olvera-Lerma, Luis Enrique Cano-Aguilar, Eduardo Corona-Rodarte","doi":"10.1159/000542573","DOIUrl":"10.1159/000542573","url":null,"abstract":"<p><strong>Introduction: </strong>Red scalp disease or scalp rosacea, an inflammatory dermatosis, is frequently misdiagnosed as scarring alopecia due to nonspecific trichoscopic findings and limited case reports. While facial rosacea is well-documented, rosacea affecting extrafacial sites, such as the scalp, remains underrecognized. Accurate diagnosis is crucial to avoid unnecessary treatments and to establish an appropriate prognosis.</p><p><strong>Case report: </strong>A 70-year-old male with an asymptomatic red scalp for 1 year, unresponsive to topical treatments, presented to our clinic. Examination revealed diffuse erythema with papules and pustules. Trichoscopy showed vascular polygons, \"caterpillar hair\" vessels, linear arterial branching, and hairpin vessels. Diagnosis of scalp rosacea was made, and significant improvement was observed after 2 months of oral tetracycline therapy.</p><p><strong>Discussion/conclusion: </strong>Red scalp disease is characterized by diffuse erythema, inflammatory lesions, and vascular changes. Patients often exhibit mild facial photosensitivity but may not show prominent facial rosacea symptoms. Distinct trichoscopic patterns can assist in accurate diagnosis. Early recognition and treatment with systemic antibiotics, such as tetracyclines, are crucial to prevent progression to more severe inflammation. Increased awareness among dermatologists and trichologists is essential to enhance the diagnosis and management of this condition.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"291-295"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 100 Most-Cited Publications in Lichen Planopilaris: A Bibliometric Analysis.","authors":"Tanya Boghosian, Narges Maskan Bermudez, Antonella Tosti","doi":"10.1159/000542898","DOIUrl":"10.1159/000542898","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planopilaris (LPP) is a rare scarring alopecia with poorly understood etiology, leading to challenges in both diagnosis and management. With an increasing number of studies focused on its clinical presentation, histopathology, and trichoscopic features, a comprehensive bibliometric analysis of high-impact LPP research is necessary to assess current trends and identify gaps in the literature.</p><p><strong>Methods: </strong>The objective of this study was to analyze trends in LPP research using the top 100 most-cited articles from Web of Science.</p><p><strong>Results: </strong>The average number of citations per article was 80.4 (range: 37-289), with publication dates ranging from 1990 to 2021. The most-cited article was Kossard's \"Progressive Frontal Scarring Alopecia in Postmenopausal Women\" with 289 citations. The USA (<i>n</i> = 47) had the most publications, followed by England (<i>n</i> = 18) and Spain (<i>n</i> = 14). Most articles were LOE 3 (<i>n</i> = 34) focusing on the \"clinical and histopathological presentation\" (<i>n</i> = 33). Key reported trichoscopic features included perifollicular erythema, perifollicular scaling, and loss of follicular ostia.</p><p><strong>Conclusion: </strong>This bibliometric analysis highlights foundational LPP studies, emphasizing key trichoscopic features while revealing gaps in high-level evidence. It underscores the need for more rigorous research and expanded geographic diversity to enhance diagnostic markers, refine trichoscopic criteria, and improve therapeutic approaches.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"245-254"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Illness Perceptions, Knowledge, and Quality of Life in Lichen Planopilaris Patients.","authors":"Azin Tahvildari, Sarina Borran, Zahra Razzaghi, Sahar Dadkhahfar","doi":"10.1159/000543451","DOIUrl":"10.1159/000543451","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planopilaris (LPP) is an inflammatory disease, leading to permanent hair loss, which significantly affects the psychosocial and self-image of patients with this condition; however, the impact of this condition on patients' quality of life (QoL), their perception of disease, and their knowledge about it have rarely been studied. This study aimed to investigate patients' knowledge and perspective on their disease and its association with their QoL and the extent of skin involvement.</p><p><strong>Methods: </strong>Patients diagnosed with LPP and confirmed through a biopsy from 2022 to 2023 completed a questionnaire covering demographic characteristics, the Illness Perception Questionnaire, disease and therapy knowledge, and the Dermatology Life Quality Index. Additionally, a dermatologist (S.D.) examined the Lichen Planopilaris Activity Index (LPPAI).</p><p><strong>Results: </strong>This study enrolled 42 LPP patients, with 81% being female and 73.8% under 60 years old. The LPPAI did not correlate with knowledge (<i>r</i> = 0.04, <i>p</i> = 0.783), illness perception (<i>r</i> = 0.097, <i>p</i> = 0.543), or QoL scores (<i>r</i> = 0.119, <i>p</i> = 0.452). However, QoL was positively linked to knowledge (<i>r</i> = 0.382, <i>p</i> = 0.013) and illness perception scores (<i>r</i> = 0.398, <i>p</i> = 0.009). Patients with a longer disease duration had higher knowledge scores (<i>r</i> = 0.400, <i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>Dermatologists should note that enhancing patients' knowledge of their disease and assessing their illness perceptions can help identify and correct misconceptions, improving treatment outcomes and their QoL.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"221-226"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mona Elradi, Dina E Hamed, Maha S Eltwansy, Doaa Hosny
{"title":"The Impact of Acne on Quality of Life: A Cross-Sectional Study from Egypt.","authors":"Mona Elradi, Dina E Hamed, Maha S Eltwansy, Doaa Hosny","doi":"10.1159/000543051","DOIUrl":"10.1159/000543051","url":null,"abstract":"<p><strong>Introduction: </strong>Nowadays, the impact of acne on the psyche of patients is evident to physicians and patients themselves. Studies concerned with the relation between acne and quality of life (QOL) are scarce in the Middle East.</p><p><strong>Methods: </strong>This prospective cross-sectional study included 247 patients. The severity of acne was evaluated using the Global Acne Grading System (GAGS). Then, patients were asked to fill in the Arabic versions of the Dermatology Life Quality Index (DLQI) and the Cardiff Acne Disability Index (CADI).</p><p><strong>Results: </strong>The mean CADI and DLQI scores were 6 ± 3.2 and 9.8 ± 5.5, respectively. There was a weakly significant positive correlation between CADI and GAGS, gender, cheek, chin, chest, and upper back localization of lesions (<i>p</i> ≤ 0.05). Moreover, there was a weakly significant positive correlation between only GAGS and DLQI (<i>r</i> = 0.125, <i>p</i> = 0.000).</p><p><strong>Conclusion: </strong>Acne has an evident negative impact on the QOL of the participants. Assessing the QOL of acne patients and psychiatric consultation are advised to be standard measures of any management approach for acne patients for their well-being.</p>","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":"11 3","pages":"255-261"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}