Scientific Reports最新文献

{"title":"Assessment of PTSD in military personnel via machine learning based on physiological habituation in a virtual immersive environment.","authors":"Gauthier Pellegrin, Nicolas Ricka, Denis A Fompeyrine, Thomas Rohaly, Leah Enders, Heather Roy","doi":"10.1038/s41598-025-91916-x","DOIUrl":"https://doi.org/10.1038/s41598-025-91916-x","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) is a complex mental health condition triggered by exposure to traumatic events that leads to physical health problems and socioeconomic impairments. Although the complex symptomatology of PTSD makes diagnosis difficult, early identification and intervention are crucial to mitigate the long-term effects of PTSD and provide appropriate treatment. In this study, we explored the potential for physiological habituation to stressful events to predict PTSD status. We used passive physiological data collected from 21 active-duty United States military personnel and veterans in an immersive virtual environment with high-stress combat-related conditions involving trigger events such as explosions or flashbangs. In our work, we proposed a quantitative measure of habituation to stressful events that can be quantitatively estimated through physiological data such as heart rate, galvanic skin response and eye blinking. Using a Gaussian process classifier, we prove that habituation to stressful events is a predictor of PTSD status, measured via the PTSD Checklist Military version (PCL-M). Our algorithm achieved an accuracy of 80.95% across our cohort. These findings suggest that passively collected physiological data may provide a noninvasive and objective method to identify individuals with PTSD. These physiological markers could improve both the detection and treatment of PTSD.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7562"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oxidative balance score and all-cause mortality in stroke survivors.","authors":"Jinglin Lei, Zhiyi Liao, Wentao Duan, Qiuli Li, Lili Duan, Hailiang Tang, Hanyao Luo, Hao Huang, Haipeng Li","doi":"10.1038/s41598-025-91721-6","DOIUrl":"https://doi.org/10.1038/s41598-025-91721-6","url":null,"abstract":"<p><p>Stroke is the second leading cause of death globally. Oxidative stress plays a critical role in the development of stroke. The Oxidative Balance Score (OBS) is a tool used to assess the combined impact of diet and lifestyle on the body's antioxidant capacity. The study included stroke survivors from the National Health and Nutrition Examination Survey (1999-2018), with a total of 1,781 participants and a median follow-up duration of 6.5 years, during which 786 participants (39.59%) died. The relationship between OBS and all-cause mortality was assessed using the Cox proportional hazards model. The results indicated that individuals in higher OBS quartiles had lower mortality rates. Specifically, patients in the fourth quartile had a 41% reduced risk of all-cause mortality compared to those in the first quartile (HR = 0.59, 95% CI = 0.42-0.84, p = 0.003). Restricted cubic spline analysis revealed a linear inverse relationship between OBS and all-cause mortality. Subgroup analysis further demonstrated that the inverse association persisted across various population subgroups. Overall, our study suggests that higher levels of OBS can reduce the risk of all-cause mortality in stroke survivors and provides new evidence for their diet and lifestyle.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7628"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and molecular marker analysis of PHS resistance of high generation wheat materials.","authors":"Heng Zhou, Qiqi Zhang, Fangfang Liu, Wenxin Cao, Yao Li, Yingxiu Wan","doi":"10.1038/s41598-025-90314-7","DOIUrl":"https://doi.org/10.1038/s41598-025-90314-7","url":null,"abstract":"<p><p>Pre-harvest sprouting (PHS) of wheat will significantly reduce the yield and quality of wheat and threaten the safety of wheat production in China. Screening and utilization of resistant germplasm and functional molecular markers is the fundamental way to reduce the harm of PHS. In this study, 238 high generation lines were used to identify and evaluate PHS resistance by grain germination method, and the distribution of PHS function markers Vp1B3, myb10-D, PM19-A1 and MFT-A2 in resistant germplasm was determined and their breeding effects were evaluated. Phenotypic identification showed that there were significant differences in the relative seed germination index (RSGI) of 238 wheat germplasm resources. The RSGI ranged from 0.03 to 1, and the average RSGI was 0.31. The difference significance analysis showed that the RSGI of the alleles of functional markers Vp1B3, PM19-A1 and MFT-A2 were significantly different, suggesting that Vp1B3, PM19-A1 and MFT-A2 could be used for detection of PHS resistance genotypes and marker-assisted breeding. Based on the phenotype and genotype results, three red wheat materials with high PHS resistance (23JD392, 23JD393 and 23JD481) and four white wheat materials with high PHS resistance (23JD025, 23JD085, 23JD541 and 23JD655) were selected. At the same time, the high resistance materials 23JD392 and 23JD393 which amplified TaVp-1Bc/TaPM19-A1a/TaMFT-A2a had the lowest RSGI. These results can be used for genetic breeding and layout of wheat varieties resistant to PHS, indicating that resistance can be significantly improved by using functional markers. This study combined molecular markers and phenotypic identification to screen anti-PHS materials, which is expected to improve the level of wheat PHS resistance.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7609"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eating distractions as predictors of ultra-processed food consumption and Mediterranean diet adherence in adolescents.","authors":"José Francisco López-Gil, Fiorella Quiroz-Cárdenas, José Adrián Montenegro-Espinosa, Emily Cisneros-Vásquez, Camila Miño, Mónica Elizabeth Castillo-Miñaca, Rubén Alejandro Unda-López, Lina América Sánchez-Charcopa, María Paula Zalamea-Delgado, Martina Jared Masache-Cruz, David Alejandro Palacios-Zavala, Mateo Alejandro Barriga-Collantes, Héctor Gutiérrez-Espinoza, Jorge Olivares-Arancibia, Rodrigo Yañéz-Sepúlveda, Carlos Hermosa-Bosano","doi":"10.1038/s41598-025-91754-x","DOIUrl":"https://doi.org/10.1038/s41598-025-91754-x","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Previous studies have examined the relationships between some eating distractions and diet quality in the young population. However, to our knowledge, no study has analyzed the associations between multiple eating distractions (e.g., using a mobile phone, watching television [TV], eating while standing) and diet quality, particularly in terms of ultra-processed food (UPF) consumption and adherence to the Mediterranean diet (MedDiet) among adolescents. The objective of the current study was to analyze the relationships of eating distractions with UPF consumption and adherence to the MedDiet in a sample of Spanish adolescents. This cross-sectional study used data from 826 adolescents aged 12-17 years from the Eating Healthy and Daily Life Activities study in Spain. The following eating distractions were assessed via a self-report questionnaire: \"(1) eating while talking on the phone/sending short message service [SMS]/emails or using social networks\", (2) watching TV while dinner, and (3) eating while standing\". The Mediterranean Diet Quality Index for children and adolescents (KIDMED) was utilized to evaluate adherence to the MedDiet. A self-administered food frequency questionnaire, previously validated for the Spanish population, was used to assess UPF consumption. The associations of eating distractions with UPF consumption and MedDiet adherence were analyzed via generalized linear models. The models were adjusted for sex, age, socioeconomic status, body mass index, physical activity, sedentary behavior, and sleep duration. A significant association was found, with a higher eating distraction score corresponding to greater UPF consumption (unstandardized beta coefficient [B] = 71.25; 95% confidence interval [CI] 34.69-107.82; p &lt; 0.001). Furthermore, a higher eating distraction score was associated with a lower KIDMED score (B - 0.29; 95% CI - 0.39 to - 0.18; p &lt; 0.001). Individually, for grams of UPFs consumed, a significant association was observed for eating while using a phone or social network, which was linked to higher UPF consumption (B = 120.70; 95% CI 57.83-183.57; p &lt; 0.001). However, the associations for eating while watching TV (B = 49.60; 95% CI - 9.01 to 108.21; p = 0.098) and eating while standing (B = 63.66; 95% CI - 37.92 to 165.25; p = 0.220) did not reach statistical significance. For KIDMED score, all the eating distractions were associated with a significant decrease, with the largest effect observed for phone or social network use (B = - 0.44; 95% CI - 0.62 to - 0.26). Watching TV (B = - 0.18; 95% CI - 0.35 to - 0.01; p = 0.037) and eating while standing (B = - 0.42; 95% CI - 0.71 to - 0.13; p = 0.004) also showed significant negative associations. Although diet quality is influenced by multiple factors, eating distractions may negatively impact adolescents by increasing UPF consumption and reducing adherence to the MedDiet. These findings underscore the importance of understanding the role of the eating environment","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7579"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Microbial safety and chemical characteristics of sausage coated by chitosan and postbiotics obtained from Lactobacillus bulgaricus during cold storage.","authors":"Shahab Sheikhi, Zahra Esfandiari, Hadis Rostamabadi, Seyed Mohammad Ali Nouri, Sahar Sabahi, Mehdi Shiri Nasab","doi":"10.1038/s41598-025-92136-z","DOIUrl":"https://doi.org/10.1038/s41598-025-92136-z","url":null,"abstract":"","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7636"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the expression of anti/pro-inflammatory cytokines in the pathogenesis and treatment of ulcerative colitis and its association with serum level of vitamin D.","authors":"Amjad Ahmadi, Rasoul Yousefimashouf, Asadollah Mohammadi, Bahram Nikkhoo, Leili Shokoohizadeh, Mohammadali Khan Mirzaei, Mohammad Yousef Alikhani, Farshad Sheikhesmaili, Hakim Khodaei","doi":"10.1038/s41598-025-87551-1","DOIUrl":"https://doi.org/10.1038/s41598-025-87551-1","url":null,"abstract":"<p><p>Ulcerative colitis is an idiopathic gastrointestinal disease described by chronic inflammation of the digestive system. Cytokines may be responsible for immunopathogenesis, mucosal and tissue damage, and even treatment response. In addition to its role in calcium and phosphorus homeostasis and bone health, vitamin D is an immunomodulatory and anti-inflammatory agent. Understanding the role of cytokines may lead to improving the pathogenesis and treatment of this disease, therefore we aimed to investigate the relative gene expression of pro- and anti-inflammatory cytokines in biopsy samples taken from the affected area in the colon of ulcerative colitis patients and its association with serum vitamin D levels. A total of 47 ulcerative colitis patients were enrolled in this case-control study. The case group consisted of 23 patients with treatment-resistant ulcerative colitis, and the control group consisted of 24 ulcerative colitis patients responding to routine treatment. Serum vitamin D levels were measured by ELISA method. Real-time PCR was employed to quantify the relative expression of pro- and anti-inflammatory cytokines in colon biopsy samples from case and control groups. The pro-inflammatory cytokines included tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, IL-17 A, and IL-33, while the anti-inflammatory cytokines were IL-10, IL-35, and TGF-β. Data are showed as mean ± standard deviation (SD), and p values < 0.05 were considered statistically significant. The mean age of the control group was 45.88 ± 18.51 years, while that of the case group was 41.30 ± 13.01 years. The relative gene expression of TNF-α, IFN-γ, IL-1β, IL-6, IL-8, IL-17 A, IL-33, TGF-β, IL-10, and IL-35, in the case and control groups did not exhibit statistically significant differences (p > 0.05). However, the gene expression levels of the principal pro-inflammatory cytokines, including IL-6, IL-1β, and TNF-α, were elevated in treatment-resistant patients compared to patients who responded to treatments. No correlation was observed between serum vitamin D levels and the gene expression of pro- and anti-inflammatory cytokines (p > 0.05). The present study did not identify a statistically significant correlation between the expression of pro- or anti-inflammatory cytokines and treatment response. Therefore, routine treatments had no effect on the expression of these cytokines in treatment-resistant patients. Additionally, serum vitamin D levels were not related to the relative expression of pro- and anti-inflammatory cytokines in the affected area of the colon of these patients. Despite the need for further research on the protective and pathological roles of cytokines and vitamin D, regular screening and early and complementary treatment may be beneficial in reducing inflammatory symptoms in these patients.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7569"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current prevalence of hepatitis delta diagnosis in Valencia, Spain.","authors":"Enrique Ortega González, María Dolores Ocete Mochón, María Martínez-Roma, Concepción Gimeno Cardona, Neus Gómez Muñoz, Moisés Diago Madrid, Alba Carrodeguas, José Luis González-Sánchez, Marta Plaza de la Torre, Miguel García Deltoro","doi":"10.1038/s41598-025-91765-8","DOIUrl":"https://doi.org/10.1038/s41598-025-91765-8","url":null,"abstract":"<p><p>Hepatitis delta virus (HDV) is the most aggressive form of chronic viral hepatitis, yet substantial knowledge gaps exist regarding its epidemiology and optimal diagnostic workflows. From February 2019 to March 2022, an HBV screening project was conducted across various healthcare settings in Valencia, Spain. This included twenty-six primary care centers, six sexual and reproductive health centers, three mental health centers, three addiction treatment centers, selected hospital departments, outpatient clinics, and a penitentiary center. A retrospective analysis of HDV diagnostic and prevalence (2007-2020) was followed by prospective HDV screening using reflex testing from April to October 2022. Of 31,995 patients screened, 141 were HBsAg-positive (0.44% seroprevalence). Previously unknown HBV infection prevalence was 0.36%. Among HBsAg-positive patients, 5.15% had HDV IgG/IgM antibodies, and 2% had HDV RNA. Reflex single-step HDV testing increased HDV diagnosis coverage from 24 to 99.4%. This study highlights the effectiveness of reflex HDV testing, which significantly increased diagnostic coverage and simplified the screening process. Reflex testing provides a cost-effective and efficient approach, particularly benefiting high-risk populations such as migrants, who accounted for 77.8% of HBsAg-positive cases. Its implementation is crucial for improving patient outcomes and addressing gaps in HDV diagnosis and management.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7584"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted degradation of CDK4/6 by LA-CB1 inhibits EMT and suppresses tumor growth in orthotopic breast cancer.","authors":"Jingliang He, Shunfang Liu, Siyi Zhang, Qi Gao, Lan Zhu, Ningyang Xu, Zhongke Hu, Xingyu Zhang, Shaojie Ma, Xiujun Wang, Bin Liu, Wei Liu","doi":"10.1038/s41598-025-92494-8","DOIUrl":"https://doi.org/10.1038/s41598-025-92494-8","url":null,"abstract":"<p><p>Cyclin-dependent kinases 4 and 6 (CDK4/6) are central regulators of cell cycle progression and frequently dysregulated in cancers, including breast cancer. While selective CDK4/6 inhibitors like Palbociclib, Ribociclib, and Abemaciclib have shown clinical benefit in hormone receptor-positive (HR+) breast cancer, their efficacy is often limited by resistance mechanisms and dose-limiting toxicities. In this study, we developed LA-CB1, a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, aiming to achieve sustained inhibition of the CDK4/6-Rb axis. LA-CB1 demonstrated potent anti-proliferative effects in various breast cancer cell lines, with notable efficacy in triple-negative breast cancer (TNBC) and HR + breast cancer models. Molecular docking studies confirmed high-affinity binding of LA-CB1 to the ATP-binding pocket of CDK4/6. Mechanistic studies revealed that LA-CB1 induces G0/G1 cell cycle arrest and promotes apoptosis through the degradation of CDK4/6. Importantly, LA-CB1 also suppressed epithelial-mesenchymal transition (EMT), inhibiting key processes such as cell migration, invasion, and angiogenesis, indicating its ability to disrupt multiple hallmarks of cancer. In an orthotopic breast cancer model, LA-CB1 significantly reduced tumor growth in a dose-dependent manner. These results suggest that LA-CB1 represents a promising therapeutic strategy by targeting CDK4/6 for degradation, addressing limitations associated with current CDK4/6 inhibitors, and providing broad anti-tumor activity in aggressive cancer types like TNBC.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7605"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of social media abstinence on affective well-being and life satisfaction: a systematic review and meta-analysis.","authors":"Laura Lemahieu, Yannick Vander Zwalmen, Marthe Mennes, Ernst H W Koster, Mariek M P Vanden Abeele, Karolien Poels","doi":"10.1038/s41598-025-90984-3","DOIUrl":"https://doi.org/10.1038/s41598-025-90984-3","url":null,"abstract":"<p><p>Abstaining from social media has become a popular digital disconnection strategy of individuals to enhance their well-being. To date, it is unclear whether social media abstinences are truly effective in improving well-being, however, as studies produce inconsistent outcomes. This preregistered systematic review and meta-analysis therefore aims to provide a more precise answer regarding the impact of social media abstinence on well-being. The databases of PubMed, Scopus, Web of Science, Communication Source, Cochrane Library, and Google Scholar were searched for studies examining the effect of social media abstinence on three outcomes, namely positive affect, negative affect, and/or life satisfaction. In total, ten studies (N = 4674) were included, allowing an examination of 38 effect sizes across these three outcomes. The analyses revealed no significant effects of social media abstinence interventions on positive affect, negative affect, or life satisfaction. Relationships between social media abstinence duration and the three outcomes were also non-significant. The findings thus suggest that temporarily stepping away from social media may not be the most optimal approach to enhance individual well-being, emphasizing the need for further research on alternative disconnection strategies. Nevertheless, important methodological differences between studies should be considered when interpreting these results.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7581"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.","authors":"Yuqi Ji, Xiao Liang, Yixiu Pei, Xiaoying Zuo, Yanyan Zhu, Jie Xu, Qinmei Kuang, Ziwei Yang, Fuqing Zhou, Yong Zhang","doi":"10.1038/s41598-025-91570-3","DOIUrl":"10.1038/s41598-025-91570-3","url":null,"abstract":"<p><p>Chronic pain is associated with persistent alterations in brain structure and function. However, existing research has not fully explored the relationship between brain network topological properties and clinical symptoms in patients with chronic low back-related leg pain (cLBLP). In this study, we collected resting-state functional and structural magnetic resonance imaging data, along with clinical symptom evaluation data, from 32 cLBLP patients and 31 healthy controls. A large-scale complex network analysis was conducted to evaluate the global and nodal topological properties of functional and structural brain networks. Statistical analyses were performed to determine the associations between network properties and clinical variables. The results showed significant alterations in both global and nodal topological properties of functional and structural brain networks in cLBLP patients compared to healthy controls. Additionally, a direct correlation was found between structural network properties and spatial discrimination ability, measured by two-point tactile discrimination values, while no significant association was observed between functional connectivity and spatial discrimination. This study demonstrates that cLBLP patients exbibit a decreased local efficiency of functional connectivity network and increased compensatory global efficiency of structural connectivity network. Notably, alterations in the structural connectome, rather than the functional connectome, play a more significant role in deterioration of foot tactile spatial acuity in cLBLP patients. Trial registration: This trial was registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2200055321 on 2022-01-06.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7515"},"PeriodicalIF":3.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}