Scientific Reports最新文献

{"title":"Study of rheological parameters due to coal particle size change in pipeline transported coal slurry.","authors":"Li-An Zhao, Chunsen Jian, Ronghuan Cai, Peng He","doi":"10.1038/s41598-024-79696-2","DOIUrl":"https://doi.org/10.1038/s41598-024-79696-2","url":null,"abstract":"<p><p>This article proposes using abrasion equilibrium equations for refining coarse-grained coal slurry hydrodynamic conveying, combining experimental data and theoretical analysis. It presents a particle refinement solution model and a viscosity prediction formula for mixed coarse and fine coal samples. Experimental data indicate that prolonged conveying time decreases coarse particle content and increases fine particles (< 0.074 mm), with a tendency for slurry viscosity to rise, though the rate of increase slows. Comparing predicted and measured particle refinement values showed a maximum deviation of 10% for 30 and 50-minute conveying times. Using the Herschel-Bulkley fluid model for viscosity prediction post-grading, verified with experimental data, the minimum viscosity value is observed at a 58% slurry concentration with varying coarse and fine coal ratios. The deviation between predicted and measured viscosity values is 5.23%, providing a formula for the viscosity reduction effect of blending.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29333"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Associations between serum cystatin C and fall reports in an Elderly population.","authors":"Jing Han, Ruiyun Wang, Lijuan Bai, Yun Liu, Man Liao, Liting Zhang, Lihua Liu, Benling Qi","doi":"10.1038/s41598-024-79849-3","DOIUrl":"https://doi.org/10.1038/s41598-024-79849-3","url":null,"abstract":"","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29392"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing prediction efficiency in the BTW and Manna sandpiles.","authors":"Denis Sapozhnikov, Alexander Shapoval, Mikhail Shnirman","doi":"10.1038/s41598-024-80621-w","DOIUrl":"10.1038/s41598-024-80621-w","url":null,"abstract":"<p><p>The state-of-the-art in the theory of self-organized criticality reveals that a certain inactivity precedes extreme events, which are located on the tail of the event probability distribution with respect to their sizes. The existence of the inactivity allows for the prediction of these events in advance. In this work, we explore the predictability of the Bak-Tang-Wiesenfeld (BTW) and Manna models on the square lattice as a function of the lattice length. For both models, we use an algorithm that forecasts the occurrence of large events after a fall in activity. The efficiency of the prediction can be universally described in terms of the event size divided by an appropriate power-law function of the lattice length. The power-law exponents are projected to be 2.75 and 3 for the Manna and BTW models respectively. The scaling with the exponent 2.75 is known for collapsing of the entire size-frequency relationship in the Manna model. However, the correspondence between events on different lattices in the BTW model requires a variety of exponents where 3 is the largest. This indicates that in thermodynamic limit, prediction does exist in the Manna but not in the BTW model, at least based on inactivity. The difference in the universality classes may underline the difference in the prediction.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29259"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instrumented swim test for quantifying motor impairment in rodents.","authors":"Natasha C Hughes, Dale C Roberts, Basile Tarchini, Kathleen E Cullen","doi":"10.1038/s41598-024-80344-y","DOIUrl":"10.1038/s41598-024-80344-y","url":null,"abstract":"<p><p>Swim tests are highly effective for identifying vestibular deficits in rodents by offering significant vestibular motor challenges with reduced proprioceptive input, unlike rotarod and balance beam tests. Traditional swim tests rely on subjective assessments, limiting objective quantification and reproducibility. We present a novel instrumented swim test using a miniature motion sensor with a 3D accelerometer and 3D gyroscope affixed to the rodent's head. This setup robustly quantifies six-dimensional motion-three translational and three rotational axes-during swimming with high temporal resolution. We demonstrate the test's capabilities by comparing head movements of Gpr156^-/- mutant mice, which have impaired otolith organ development, to their heterozygous littermates. Our results show axis-specific differences in head movement probability distribution functions and dynamics that identify mice with the Gpr156 mutation. Axis-specific power spectrum analyses reveal selective movement alterations within distinct frequency ranges. Additionally, our spherical visualization and 3D analysis quantifies swimming performance based on head vector distance from upright. We use this analysis to generate a single classifier metric-a weighted average of an animal's head deviation from upright during swimming. This metric effectively distinguishes animals with vestibular dysfunction from those with normal vestibular function. Overall, this instrumented swim test provides quantitative metrics for assessing performance and identifying subtle, axis- and frequency-specific deficits not captured by existing systems. This novel quantitative approach can enhance understanding of rodent sensorimotor function including enabling more selective and reproducible studies of vestibular-motor deficits.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29270"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, molecular docking, pharmacokinetics, and molecular dynamics of new bis-thiazoles based on bis-thiosemicarbazone as anti-coxsackievirus.","authors":"Thoraya A Farghaly, Eman M H Abbas, Heba S Abd-Elghaffar, Mohamed A Elsayed, Dina H Elnaggar, Ahmed F El-Sayed, Dina N Abd-Elshafy, Salwa F Mohamed","doi":"10.1038/s41598-024-80753-z","DOIUrl":"https://doi.org/10.1038/s41598-024-80753-z","url":null,"abstract":"<p><p>It was known that the majority of viral infections start off as cutaneous eruptions, which heal on their own in most cases. The prognosis is dependent on the state of immunologic surveillance, just like in other infectious disorders. Therefore, those who are immunosuppressed are more in danger. But recently it's becoming increasingly clear that eruptions that were once thought to be benign diseases can really cause problems and even death, even in immunocompetent patients. Hence, in this article, our goal was to identify possible potential antiviral candidates. We have synthesized a series of bis-thiazole derivatives via the reaction of bis-thiosemicarbazone derivative 3 with hydrazonoyl chlorides and haloketones in an effort to examine their potential antiviral properties and interactions with the main protease of Coxsackievirus B. Spectroscopic methods and elemental analysis were used to corroborate the structures of the novel bis-thiazole derivatives. The most potent derivative, bis-thiazole derivative 7a, was found to have the strongest antiviral activity against Coxsackievirus B (Cox B). Further investigation into its mode of action indicated that compound 7a has a dual activity that inhibits viral adsorption and replication. The efficacy of many compounds against Coxsackievirus adenovirus targets was assessed using molecular docking. The findings revealed that compounds 7a, 7c, 11b and 11c have high binding energies, efficiently engaging the active sites of essential Cox B virus proteins such as the Coxsackievirus adenovirus receptor (CAR), 3C-protease, and RNA-dependent RNA polymerase (RdRp). These interactions involved a variety of chemical bonding types, indicating that these substances can inhibit enzyme activity while also exhibiting substantial antiviral effects involving viral replication and adsorption. Furthermore, the computational ADMET study of these compounds indicated conformance to Lipinski's criteria, implying positive physicochemical properties. Furthermore, MD simulations demonstrated stable complexes of 7a and 11b with Coxsackievirus adenovirus receptor (CAR), 3C-protease, and RNA dependent RNA polymerase (RdRp) with RMSD (0.1-0.30, 0.20-0.30, and 0.20-0.35 nm), RMSF (0.1-0.5 nm), and SASA (80-105, 140-150, and 220-235). These outcomes further reinforce the potential of these compounds in current antiviral drug development endeavors. The collective findings underscore the potential of these compounds as candidates for antiviral therapies against Coxsackievirus adenovirus.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29378"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expansion mechanism of expansive surrounding rock in Guiyang City, China.","authors":"Chenggui Wu, Junying Rao, Xing Peng, Chaoying Chen, Yi Chen, Hongchao Cui","doi":"10.1038/s41598-024-80945-7","DOIUrl":"https://doi.org/10.1038/s41598-024-80945-7","url":null,"abstract":"<p><p>Expansive surrounding rock, such as mudstone, poses significant risks to supporting structures like tunnel linings due to its tendency to expand. To explore the expansion mechanism of expansive surrounding rock and address underground engineering challenges associated with it, this study, based on the first phase of Guiyang Metro Line S1, samples expansive surrounding rock from the section and conducts basic physical tests, X-ray diffraction (XRD), and scanning electron microscopy (SEM) analyses on the samples. The influence of water content (0%, 2.93%, 6.84%, and 8.20%) on the mechanical properties of mudstone, as well as its expansion characteristics under natural conditions, were examined. Results indicate that the microscopic surface of mudstone is rough, with cracks distributed around pores. These elements interconnect to form natural water channels, with clay minerals and non-clay minerals comprising 47.2% and 52.8% of the sample, respectively. Mudstone contains multiple pores that gradually develop as water content increases. Mudstone expansion significantly reduces its compressive strength. When lateral constraints are applied, mudstone exhibits significantly greater expansion compared to axial and radial changes. When mudstone encounters water, the expansion pressure fluctuates significantly. Upon water absorption following dehydration, cracks in the rock sample develop rapidly, accelerating collapse. These findings offer valuable insights for the construction and design of tunnels in expansive surrounding rock formations within karst areas.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29338"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation of a Rohksar-Kivelson ladder on a NISQ device.","authors":"Sabhyata Gupta, Younes Javanmard, Tobias J Osborne, Luis Santos","doi":"10.1038/s41598-024-79480-2","DOIUrl":"10.1038/s41598-024-79480-2","url":null,"abstract":"<p><p>We present a quantum-classical algorithm to study the dynamics of the Rohksar-Kivelson plaquette ladder on NISQ devices. We show that complexity is largely reduced using gauge invariance, additional symmetries, and a crucial property associated to how plaquettes are blocked against ring-exchange in the ladder geometry. This allows for an efficient simulation of sizable plaquette ladders with a small number of qubits, well suited for the capabilities of present NISQ devices. We illustrate the procedure for ladders with simulation of up to 8 plaquettes in an IBM-Q machine, employing scaled quantum gates.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29276"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-200 family as new potential prognostic factor of overall survival of patients with WHO G2 and WHO G3 brain gliomas.","authors":"Mateusz Bilski, Marzanna Ciesielka, Magdalena Orzechowska, Bożena Jarosz, Paulina Całka, Sylwia Bilska, Agata Banach, Gabriela Czaja, Jacek Fijuth, Łukasz Kuncman","doi":"10.1038/s41598-024-80656-z","DOIUrl":"https://doi.org/10.1038/s41598-024-80656-z","url":null,"abstract":"<p><p>Gliomas are the predominant cause of cancer-related deaths among the young population. Even after incorporation of IDH1/2 mutations and 1p19q codeletion there are doubts regarding adjuvant treatment in WHO G2/G3 gliomas. miRNA molecules control about 30% of all genes, also many oncogenes, tumor suppressor genes and genes responsible for the response to ionizing radiation and systemic treatment. Patients with brain gliomas exhibit miRNA disorders. We aimed to evaluate the expression of miR-200 family members in relation to selected clinico-pathological factors and their prognostic value. We enrolled 53 patients diagnosed with WHO G2/G3 brain gliomas treated between 2012-2016. RT-qPCR based expression of miR-200 family was assessed in tumor and surrounding non-cancerous tissue. An analysis of selected clinico-pathological features was carried out. A logistic regression model was prepared for the miRNA signature. The predictive potential of the signature was assessed using the ROC curve. A stepwise backward regression model was used to select variables with a significant predictive potential related to OS. It was shown that miR-200a-3p, miR-200a-5p, miR-200c-5p, miR-141-3p and miR-429 can be independent predictors of survival. Better 2- and 5-year OS was associated with higher expression of miR-200a-3p, miR141-3p and lower expression of miR-200a-5p, miR-200c-5p, miR-429. The strongest predictors of survival were miR-200a-5p, miR-200b-3p, miR-200c-5p, miR-141-3p, miR-429, tumor volume and CTV. Members of the miR-200 family exhibit prognostic value for 2- and 5-year OS. Presented predictive models of survival may be clinically useful for treatment optimization.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29345"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics analysis reveals resembling metabolites between humanized γδ TCR mice and human plasma.","authors":"Husheem Michael, Gene W Weng, Mikaela M Vallas, Douglas Lovos, Ellen Chen, Paul Sheiffele, Wei Weng","doi":"10.1038/s41598-024-81003-y","DOIUrl":"https://doi.org/10.1038/s41598-024-81003-y","url":null,"abstract":"<p><p>Gamma delta (γδ) T cells, which reside in mucosal and epithelial tissues, are integral to immune responses and are involved in various cancers, autoimmune, and infectious diseases. To study human γδ T cells to a translational level, we developed γδ humanized TCR-T1 (HuTCR-T1) mice using our TruHumanization platform. We compared the metabolomic profiles from plasma samples of wild-type (WT), γδ HuTCR-T1 mice, and humans using UHPLC-MS/MS. Untargeted metabolomics and lipidomics were used to screen all detectable metabolites. Principal component analysis revealed that the metabolomic profiles of γδ HuTCR-T1 mice closely resemble those of humans, with a clear segregation of metabolites between γδ HuTCR-T1 and WT mice. Most humanized γδ metabolites were classified as lipids, followed by organic compounds and amino acids. Pathway analysis identified significant alterations in the metabolism of tryptophan, tyrosine, sphingolipids, and glycerophospholipids, shifting these pathways towards a more human-like profile. Immunophenotyping showed that γδ HuTCR-T1 mice maintained normal proportions of both lymphoid and myeloid immune cell populations, closely resembling WT mice, with only a few exceptions. These findings demonstrate that the γδ HuTCR-T1 mouse model exhibits a metabolomic profile that is remarkably similar to that of humans, highlighting its potential as a relevant model for investigating the role of metabolites in disease development and progression. This model also offers an opportunity to discover therapeutic human TCRs.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29321"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eEF2K as an important kinase associated with cancer survival and prognosis.","authors":"Nan Wang, Li-Lan Cen, Zhe Tian, Miao-Miao An, Qian Gu, Xin-Hong Zhou, Yi-He Zhang, Lucas Liu, Jun Zhang, Di Yang, Yong-Zhi Huang, Xi-Dai Long, Qian Yang","doi":"10.1038/s41598-024-78652-4","DOIUrl":"https://doi.org/10.1038/s41598-024-78652-4","url":null,"abstract":"<p><p>Eukaryotic Elongation Factor 2 Kinase (eEF2K), a member of the α-kinase family, services as a crucial negative regulator of protein synthesis, particularly under conditions of cellular stress. A pan-cancer analysis of eEF2K expression, genetic variants, and clinical relevance across multiple tumor types was performed using data from the Cancer Genome Atlas (TCGA) and GEO. Our findings suggest that eEF2K has dual roles in cancer progression, with its expression correlating with patient prognosis. Significant phosphorylation of eEF2 at T57, Y434, and T59 was observed, which may regulate protein synthesis during stress. The elevated T59 phosphorylation in COAD, despite the low eEF2K expression, indicates that this may be regulated by alternative kinases, such as AMPK or mTOR. This suggests that compensatory mechanisms may be involved. In addition to modulating eEF2 phosphorylation, eEF2K is involved in a number of other processes, including peptidyl-serine phosphorylation, the G2/M transition, and the MAPK cascade. The protein products of eEF2K are capable of localizing to the nucleus, cytoplasm, and cytosol, where they bind to a range of proteins, including ATP and calcium ions. These findings provide novel insights into the role of eEF2K in cancer biology and suggest that the targeting of eEF2K and eEF2 phosphorylation may offer promising therapeutic strategies.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29284"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}