Scientific Reports最新文献

{"title":"Predictive and clinicopathological importance of HMGB2 in various carcinomas: a meta and bioinformatic approach.","authors":"Yinan Zhu, Siyu He, Ziyue Wang, Haiyan Xi, Wanchen Lu, Xuyong Lin","doi":"10.1038/s41598-025-95505-w","DOIUrl":"https://doi.org/10.1038/s41598-025-95505-w","url":null,"abstract":"<p><strong>Background: </strong>High mobility group box 2 (HMGB2), one of the HMGB domain proteins, may play a significant role in cancer development and progression. Recent scientific investigations have hinted at the potential clinical relevance of HMGB2, particularly in cancer patients where its expression levels have been observed to be elevated. However, the precise impact of HMGB2 on the prognosis of tumors remains an area of ongoing research. To the best of our understanding, our study represents a meta-analysis that elucidates a connection between HMGB2 expression and the clinical outcomes of diverse cancer types.</p><p><strong>Method: </strong>We executed a thorough and systematic search of literature across PubMed, Web of Science, Embase, CNKI, and Wanfang databases. Following this, we conducted a quantitative meta-analysis using statistical tools such as StataMP16 and RevMan5.3. The primary focus of our analysis was to assess the relationship between HMGB2 expression levels and overall survival (OS), disease-free survival (DFS), as well as various clinicopathological characteristics of cancer patients by calculating the hazard ratio (HR). Additionally, we validated our findings by examining HMGB2 expression patterns across different cancer types using the Gene Expression Profiling Interactive Analysis (GEPIA) online platform.</p><p><strong>Result: </strong>Our meta-analysis incorporated data from 17 studies, encompassing a total of 2555 cancer patients. The results revealed a statistically significant association between high HMGB2 expression and shorter OS (HR, 1.40 ;95% CI: 1.10-1.70; P < 0.001), especially in digestive cancer ( HR, 2.09 (95% CI: 1.54-2.63; I² = 0.0%,P = 0.424). Furthermore, GEPIA analysis demonstrated a consistent upregulation of HMGB2 in most cancer types, with a downregulation between HMGB2 and LAML.</p><p><strong>Conclusion: </strong>Our findings underscore a detrimental correlation between the upregulation of HMGB2 and the prognosis of various cancers. This discovery could pave the way for the development of innovative prognostic biomarkers and therapeutic targets that specifically target HMGB2, offering new avenues for the management and treatment of cancer patients.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11003"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of gluten and soy derived excipients in medicinal products and their implications on allergen safety and labeling.","authors":"Alexandra Figueiredo, Maria Deolinda Auxtero, Adriana Brás, Andreia Casimiro, Isabel Margarida Costa","doi":"10.1038/s41598-025-95525-6","DOIUrl":"https://doi.org/10.1038/s41598-025-95525-6","url":null,"abstract":"<p><p>Gluten and soy allergies are significant health concerns, particularly in individuals with celiac disease or soy sensitivity. While dietary sources of these allergens are well-studied, their presence in medicinal products remains under-explored. This study assessed the prevalence of gluten and soy-derived excipients in 308 medicinal products authorized for marketing in Portugal. A systematic search of the Summary of Product Characteristics (SmPC) database was conducted for 108 analgesics and antipyretics containing paracetamol, 85 NSAIDs containing ibuprofen, and 115 antiasthmatic and bronchodilator medicinal products. The study found significant associations between pharmacotherapeutic groups and the presence of these allergens (p < 0.001). Gluten was more prevalent in the group of analgesics and antipyretics (44.4%) than in NSAIDs (8.2%), whereas soy-derived excipients were more frequent in NSAIDs (14%) than in analgesics and antipyretics (6.5%). No excipients containing gluten or soy were identified in antiasthmatic and bronchodilator medicinal products. In analgesics and antipyretics, 51.2% of solid oral dosage forms and 40% of liquid oral formulations contained gluten. Within the NSAIDs group, gluten was mainly present in liquid oral dosage forms (26.7%). Soy-derived excipients were found in 30% of liquid oral formulations and in 33.3% of rectal dosage forms of analgesics and antipyretics. In the NSAIDs group, soy was more prevalent in liquid oral formulations (26.7%). These findings highlight the need for clearer labeling of allergens in medicinal products and underscore the importance of vigilance for patients with gluten or soy allergies. Further research is required to address gaps in allergen disclosure by pharmaceutical manufacturers and to promote safer medicinal product use for sensitive populations. Enhanced awareness among healthcare providers and patients is essential to mitigate the risk of allergic reactions associated with hidden excipients in medicinal products.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10976"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing zinc and iron biofortification in mungbean (Vigna radiata L.) through various application method.","authors":"Hafsa Farooq, Rimsha Ishtiaq, Haris Babar, Mohammad Hashim Faryad, Maria Ameen, Muhammad Taqqi Abbas, Zain Mushtaq, Abdulrahman Alasmari, Md Sabir Ahmed Mondol, Gholamreza Abdi","doi":"10.1038/s41598-025-95441-9","DOIUrl":"https://doi.org/10.1038/s41598-025-95441-9","url":null,"abstract":"<p><p>Malnutrition is a problem in many developing economies where cereal crops are the main source of nutrition. Zinc and iron, important micronutrients, play an important role in the physiological and metabolic mechanisms of plants and humans. In this study a field experiment was conducted at the Agronomic Research Area, University of Agriculture, Faisalabad during zaid rabi season in February 2023 to check the impact of different application methods (seed priming, seed coating, soil application, and foliar application) of Zn and Fe on grain zinc and iron content and productivity in mungbean.. Results show that the plant growth parameters are significantly influenced by the concentration and application method of Zn and Fe. The highest plant height (cm), maximum number of branches and pods on plants were observed in foliar application of Zn and Fe combination treatment.. Post-harvest parameters, including biological yield, grain yield and 1000 seed weight were also positively influenced with highest biological yield (4536.27 kg ha^-1) and grain yield (1927 kg ha^-1) recorded under Zn foliar application. Physiological parameters such as chlorophyll content (SPAD value) and photosystem II Yield (Y(II)) were significantly improved with Zn and Fe treatment, particularly under foliar application. Biochemical analyses revealed that Zn and Fe significantly increase Zn and Fe content in grains with the highest value (36.77 and 63.44 ppm, respectively) observed under Zn foliar treatment. Overall, the foliar application was found most effective, in improving the yield and quality of mungbean. These findings highlight the efficacy of foliar application of Zn and Fe in enhancing mungbean growth, yield, and nutrient content, providing valuable insights for optimizing micronutrient management in mungbean cultivation.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10974"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantum random access memory (QRAM) using a polynomial encoding of binary strings.","authors":"Priyanka Mukhopadhyay","doi":"10.1038/s41598-025-95283-5","DOIUrl":"https://doi.org/10.1038/s41598-025-95283-5","url":null,"abstract":"<p><p>Quantum algorithms claim significant speedup over their classical counterparts for solving many problems. An important aspect of many of these algorithms is the existence of a quantum oracle, which needs to be implemented efficiently in order to realize the claimed advantages in practice. A quantum random access memory (QRAM) is a promising architecture for realizing these oracles. In this paper we develop a new design for QRAM and implement it with Clifford+T circuit. We focus on optimizing the T-count and T-depth since non-Clifford gates are the most expensive to implement fault-tolerantly in most error correction schemes. Integral to our design is a polynomial encoding of bit strings and so we refer to this design as [Formula: see text]. Compared to the previous state-of-the-art bucket brigade architecture for QRAM, we achieve an exponential improvement in T-depth, while reducing T-count and keeping the qubit-count same. Specifically, if N is the number of memory locations to be queried, then [Formula: see text] has T-depth [Formula: see text], T-count [Formula: see text] and uses O(N) logical qubits, while the bucket brigade circuit has T-depth [Formula: see text], T-count O(N) and uses O(N) qubits. Combining two [Formula: see text] we design a quantum look-up-table, [Formula: see text], that has T-depth [Formula: see text], T-count [Formula: see text] and qubit count [Formula: see text]. A quantum look-up table (qLUT) or quantum read-only memory (QROM) has restricted functionality than a QRAM. For example, it cannot write into a memory location and the circuit needs to be compiled each time the contents of the memory change. The previous state-of-the-art CSWAP architecture has T-depth [Formula: see text], T-count [Formula: see text] and qubit count [Formula: see text]. Thus we achieve a double exponential improvement in T-depth while keeping the T-count and qubit-count asymptotically same. Additionally, with our polynomial encoding of bit strings, we develop a method to optimize the Toffoli-count of circuits, specially those consisting of multi-controlled-NOT gates.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11002"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the PEDOT-polypyrrole hybrid electrode for the electrochemical sensing of dopamine.","authors":"Anandhavelu Sanmugam, C Vanitha, Abdulrahman I Almansour, K Karuppasamy, T Maiyalagan, Hyun-Seok Kim, Dhanasekaran Vikraman, Akram Alfantazi","doi":"10.1038/s41598-024-82355-1","DOIUrl":"https://doi.org/10.1038/s41598-024-82355-1","url":null,"abstract":"<p><p>This study presents the electrochemical sensing of dopamine (DA) using an electrode of polypyrrole/poly(3,4-ethylenedioxythiophene) (PEDOT-PPy) thin film. Electrochemical analyses of the PEDOT-PPy thin film for DA sensing were conducted through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The CV analysis demonstrated that PEDOT-PPy exhibited superior electrochemical activity towards DA due to its enhanced conductivity as a high-conducting polymer composite. The DPV results indicated a linear concentration level of 5 nM to 200 µM with a minimal limit of sensing of 5 nM using the PEDOT-PPy electrode material. The fabricated sensor explored the sensitivity of 7.27 µA/µM cm² at the 5 to 1000 nM DA concentration and the dopamine diffusion coefficient of 1.3 × 10^-8 cm²/s. Additionally, the PEDOT-PPy electrode material displayed excellent reproducibility, selectivity, and stability. Therefore, the PEDOT-PPy composite electrode material shows excellent potential for outperforming other electrode materials in detecting DA.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10989"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vehicular mediated emissions of polycyclic aromatic hydrocarbons in roadside soils of Shanghai.","authors":"Qi Huang, Min Xu, Yingying Zhu, Xin Li, Jiadong Xu, Xiaojian Li, Ying Lu","doi":"10.1038/s41598-025-93715-w","DOIUrl":"https://doi.org/10.1038/s41598-025-93715-w","url":null,"abstract":"<p><p>This study evaluates the impact of vehicular emissions on polycyclic aromatic hydrocarbons (PAHs) in roadside soils in Shanghai during the COVID-19 lockdown period. Soil samples from roadside lawns were collected, with PAH concentrations ranging from 153 to 5639 ng g^-1. A significant reduction in PAH levels compared to their pre-COVID-19 levels (Kruskal-Wallis H test, p < 0.05) was observed in surface soil samples, highlighting the contribution of traffic and coal combustion to urban pollution. Source identification, using molecular diagnostic ratios and principal component analysis, revealed that vehicular emissions were the primary contributors to PAHs in Shanghai's roadside soils. The toxic equivalent quantity for benzo[a]pyrene concentrations in the soil samples was associated with these sources. The incremental lifetime cancer risk model indicated that adult exposure to PAHs in the soil posed health risks greater than 10^-6 but lower than 10^-4, suggesting a low-risk level. These findings suggest that targeted measures in the transportation sector could improve urban soil quality and reduce associated health risks.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10981"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the P-coumaric acid protection against bisphenol A-induced hepatotoxicity in in vivo and in silico models.","authors":"Samet Tekin, Merve Bolat, Aslıhan Atasever, İsmail Bolat, Burak Çinar, Azizeh Shadidizaji, Yusuf Dağ, Emin Şengül, Serkan Yildirim, Ahmet Hacimuftuoglu, Mohamad Warda","doi":"10.1038/s41598-025-87099-0","DOIUrl":"https://doi.org/10.1038/s41598-025-87099-0","url":null,"abstract":"<p><p>Bisphenol A (BPA), commonly found in plastic containers and epoxy resins used for food products, presents substantial health risks, particularly in relation to hepatic toxicity. This study investigates BPA-induced liver damage and explores the mechanistic dose-dependent protective effects of P-coumaric acid (PCA). 50 male rats were divided into control, BPA-treated, BPA + PCA50, BPA + PCA100, and PCA100 groups. BPA exposure for 14 days induced oxidative stress, evidenced by elevated malondialdehyde levels and decreased activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Higher doses of PCA effectively mitigated these effects by restoring redox balance and enhancing antioxidant enzyme activities. Additionally, BPA disrupted inflammation and apoptosis pathways, inhibiting anti-inflammatory markers and interfering with the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway. PCA exhibited dose-dependent protection against these disruptions. Computational analyses revealed that BPA inhibits cyclooxygenase-1 through stable hydrogen bonding with threonine at position 322. PCA's dual protective effect was confirmed by attenuating inflammatory pathways, including TNF-α inhibition and suppression of the Kelch-like ECH-associated protein 1 (KEAP1) and Nrf2 signaling pathway. Histopathological assessments confirmed that PCA alleviated significant hepatic damage induced by BPA. Immunohistochemical and immunofluorescence analyses further supported PCA's protective role against BPA-induced apoptosis and cellular hepatotoxicity. These findings underscore PCA's protective potential against BPA-induced hepatotoxicity and highlight novel mechanistic interactions that warrant further investigation in applied nutritional biochemistry.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11023"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on the change rule of different characteristic parameters with depth in expansion soil graben slopes.","authors":"Chaozheng Shen, Xueyun Miao, Yongqiang Li","doi":"10.1038/s41598-025-96062-y","DOIUrl":"https://doi.org/10.1038/s41598-025-96062-y","url":null,"abstract":"<p><p>Expansive soil due to wet expansion and dry contraction of engineering properties, resulting in the stability of the riffle slope, has been one of the key issues in the expansion of soil area earthworks; this paper, through the three representative riffle slope site field visits and indoor tests, respectively, from the dry bulk weight, unconfined compressive strength, three-way expansion force and expansion with the change rule of the depth of the law to be explored. The three-way expansion force test shows that the extension and proximity direction of the horizontal expansion force are the same. The vertical direction is greater than the horizontal direction, and its ratio is about 0.5. Further analysis of the relationship between the characteristics of the parameters with the depth can be seen: the surface soil indicators are more varied, between 0.5 and 1.0 m, the soil layer dry density is small, the expansion of the soil wet expansion and drying shrinkage is significant, and the unconfined compressive strength is close to or has reached the lowest value; expansion force and expansion volume test indicators along the depth of the graben slope, the expansion force and expansion volume test indicators are more varied. Expansion force and expansion amount test indexes change along the depth of the riffle slope but remain unchanged after 2.0 m. Therefore, the damage of the expansion soil riffle slope mainly occurs in the soil layer near the depth of 1.0 m, which is manifested explicitly as a failure to adapt to the change of stress in the soil and the inability to adjust to the atmospheric natural camping force.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10978"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach.","authors":"Payam S Shabestari, Stefan Schoisswohl, Zino Wellauer, Adrian Naas, Tobias Kleinjung, Martin Schecklmann, Berthold Langguth, Patrick Neff","doi":"10.1038/s41598-025-95351-w","DOIUrl":"https://doi.org/10.1038/s41598-025-95351-w","url":null,"abstract":"<p><p>Tinnitus is defined as the perception of sound without an external source. Its perceptual suppression or on/off states remain poorly understood. This study investigates neural traits linked to brief acoustic tinnitus suppression (BATS) using naive resting-state EEG (closed eyes) from 102 individuals. A set of EEG features (band power, entropy, aperiodic slope and offset of the EEG spectrum, and connectivity) and standard classifiers were applied achieving consistent high accuracy across data splits: 98% for sensor and 86% for source models. The Random Forest model outperformed other classifiers by excelling in robustness and reduction of overfitting. It identified several key EEG features, most prominently alpha and gamma frequency band power. Gamma power was stronger in the left auditory network, while alpha power dominated the right hemisphere. Aperiodic features were normalized in individuals with BATS. Additionally, hyperconnected auditory-limbic networks in BATS suggest sensory gating may aid suppression. These findings demonstrate robust classification of BATS status, revealing distinct neural traits between tinnitus subpopulations. Our work emphasizes the role of neural mechanisms in predicting and managing tinnitus suppression. Moreover, it advances the understanding of effective feature selection, model choice, and validation strategies for analyzing clinical neurophysiological data in general.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10968"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of clinical trial eligibility in patients with advanced gastric cancer.","authors":"Takaaki Arigami, Daisuke Matsushita, Masataka Shimonosono, Yuki Hirase, Yusuke Tsuruda, Ken Sasaki, Kenji Baba, Yota Kawasaki, Takao Ohtsuka","doi":"10.1038/s41598-025-95501-0","DOIUrl":"https://doi.org/10.1038/s41598-025-95501-0","url":null,"abstract":"<p><p>The CheckMate 649 trial demonstrated the clinical benefit of nivolumab plus chemotherapy in patients with human epidermal growth factor receptor 2 (HER2)-negative advanced gastric cancer. However, the background discrepancy between clinical practice and randomized controlled trials may impact the therapeutic strategy and prognosis of patients. This study aimed to assess the clinical significance of eligibility criteria determined by the CheckMate 649 trial and identify prognostic factors in clinical practice. A total of 160 patients with HER2-negative metastatic gastric cancer who underwent chemotherapy were retrospectively enrolled and classified into two groups based on eligibility criteria. Among the 160 patients, 76 (47.5%) and 84 (52.5%) were included in the eligible and ineligible groups, respectively. The ineligible group had a significantly lower induction of second- and third-line chemotherapy than the eligible group (P = 0.02 and P = 0.02, respectively). The median overall survival in the eligible and ineligible groups was 22.9 and 10.5 months, respectively, with the ineligible group having a significantly poorer prognosis than the eligible group (P < 0.01). Responders to first-line chemotherapy had a better prognosis than non-responders in both groups (P = 0.01 and P < 0.01, respectively). Multivariate analyses identified disease control as an independent prognostic factor in both groups (P < 0.01 and P < 0.01, respectively). Patients with a poor general condition who fulfilled the ineligibility criteria as determined using randomized controlled trials are included in clinical practice, and these criteria are related to tumor response and prognosis.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"10961"},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}