Scientific Reports最新文献_第5页

Assessing proxy and AI models performance in waterflooding optimization. 评估代理和人工智能模型在水驱优化中的性能。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19256-4

Yaser Abdollahfard, Jalal Fahimpour, Mohammad Ahmadi

引用次数: 0

An efficient charging strategy for wireless sensor networks based on saturation degree and Enhanced Grey Wolf optimization. 一种基于饱和度和增强灰狼优化的无线传感器网络收费策略。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19243-9

P Neelagandan, S Balaji

{"title":"An efficient charging strategy for wireless sensor networks based on saturation degree and Enhanced Grey Wolf optimization.","authors":"P Neelagandan, S Balaji","doi":"10.1038/s41598-025-19243-9","DOIUrl":"10.1038/s41598-025-19243-9","url":null,"abstract":"Wireless sensor networks play a vital role in a wide range of modern applications, from environmental monitoring to industrial automation. A key challenge in maintaining the long-term functionality of these networks lies in effective energy management, where recharging sensors is often more practical and economical than frequent battery replacement. One critical aspect of this process is the optimal placement of chargers to ensure maximum sensor coverage while minimizing deployment costs. This paper presents a hybrid optimization framework that combines graph-theoretical concepts-specifically the Degree of Saturation approach-with the Enhanced Grey Wolf Optimization algorithm to solve the charger placement problem in WSNs. The Degree of Saturation method identifies independent groups of sensors to reduce the number of chargers required, while Enhanced Grey Wolf Algorithm determines their optimal spatial positions to ensure efficient energy replenishment. Extensive simulations demonstrate the superiority of the proposed method over conventional techniques. Compared to wavelet-based approaches such as Haar (83%), Daubechies 2 (85%), Biorthogonal (86%), and Symlets 8 (85%), as well as evolutionary algorithms like Raindrop (87%) and Blackhole (91%), the proposed Enhanced Grey Wolf Optimization-based method achieves a significantly higher efficiency of 97%. These results highlight the robustness and effectiveness of the proposed approach for real-world Wireless sensor networks deployment.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35461"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel midgut smooth muscle necrosis (MSMN) in translucent or glass post-larvae of whiteleg shrimp. 白腿虾半透明或玻璃状幼虫的新型中肠平滑肌坏死。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19591-6

Jiraporn Srisala, Piyachat Sanguanrut, Sorawit Powtongsook, Krit Khemayan, Kallaya Sritunyalucksana, Timothy W Flegel

{"title":"Novel midgut smooth muscle necrosis (MSMN) in translucent or glass post-larvae of whiteleg shrimp.","authors":"Jiraporn Srisala, Piyachat Sanguanrut, Sorawit Powtongsook, Krit Khemayan, Kallaya Sritunyalucksana, Timothy W Flegel","doi":"10.1038/s41598-025-19591-6","DOIUrl":"10.1038/s41598-025-19591-6","url":null,"abstract":"From the Asia-Pacific region, the suspected TPD/GPD specimens of postlarvae (PL) at 9 days of development (PL9) preserved in Davidson's fixative and 95% ethanol were sent to our laboratory to prepare for PCR and histological analysis. Interestingly, PCR tests with the specimens were negative with the VPHLVD (vtcc2 and vtcc3 gene) primers, but positive with the VPTPD (vhvp-2 gene) primers. There were no characteristic lesions of acute hepatopancreatic necrosis disease detected in these specimens. However, in the sections of several specimens from two affected tanks, the midgut was cut tangentially in the abdominal region, revealing a novel histopathology characterized by severe necrosis specifically in the thin, smooth muscle tissues underlying the midgut lumen epithelium. This comprised nuclear pyknosis and karyorrhexis limited to the smooth muscle and occasionally affecting the midgut epithelium but not involving the surrounding skeletal muscles. The pathology is called midgut smooth muscle necrosis (MSMN). Such pathology would undoubtedly lead to loss of midgut peristalsis and cessation of feeding, but it could be easily overlooked without careful histological examination using a high magnification microscope objective. No bacterial cells were evident, suggesting that the lesions arose from a virus or from a specific toxin response. This report is an urgent plea for colleagues studying TPD/GPD to review their samples histologically to help in determining whether MSMN is pathognomonic for TPD/GPD.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35544"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast milk stem cells integrate into cellular remodeling and functional differentiation in the ischemic brain. 母乳干细胞整合到缺血脑的细胞重塑和功能分化中。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-18917-8

Esra Nur Yİğİt, Safiye Serdengeçtİ, Ayşe Server Sezer, Emre Vatandaşlar, Serdar Altunay, Ahmet Burak Çağlayan, Taha Keleştemur, Gürkan Öztürk, Mehmet Şerif Aydin

{"title":"Breast milk stem cells integrate into cellular remodeling and functional differentiation in the ischemic brain.","authors":"Esra Nur Yİğİt, Safiye Serdengeçtİ, Ayşe Server Sezer, Emre Vatandaşlar, Serdar Altunay, Ahmet Burak Çağlayan, Taha Keleştemur, Gürkan Öztürk, Mehmet Şerif Aydin","doi":"10.1038/s41598-025-18917-8","DOIUrl":"10.1038/s41598-025-18917-8","url":null,"abstract":"Breast milk serves as a critical source of nutrition for infants and significantly impacts their developmental trajectories and health outcomes throughout their lives. This study investigates the role of breast milk-derived stem cells (BMSCs) and their potential involvement in recovery following brain ischemia. Prior research has demonstrated that BMSCs can migrate into the digestive tract of nursing offspring and subsequently differentiate into various cell types, including neurons and astrocytes within the brain. Our study aims to elucidate whether these differentiated BMSCs contribute to cellular recovery in response to ischemic events in a mouse model. Utilizing a cerebral ischemia/reperfusion (I/R) model, we found that maternal transfer of BMSCs through breastfeeding allows these cells to reach the central nervous system (CNS) of offspring and persist into adulthood. Notably, following ischemic injury, we observed enhanced recruitment and differentiation of these BMSCs into neuronal and glial lineages specifically in the peri-infarct region. This study represents the first evidence of a natural stem cell-mediated repair mechanism within the injured CNS facilitated by maternal breastfeeding, revealing significant implications for therapeutic strategies targeting maternal-neonatal interactions. Our findings suggest that BMSCs may play a protective role in the aftermath of cerebral ischemic injury. These findings reveal a natural, maternally derived stem cell-mediated repair mechanism in the injured CNS, highlighting BMSCs' dual role in development and pathology in adulthood.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35422"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy efficient clustering in industrial Iot using a quantum informed artificial hummingbird optimization algorithm. 基于量子信息人工蜂鸟优化算法的工业物联网节能聚类。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19358-z

S Rajkumar, R Gopalakrishnan

{"title":"Energy efficient clustering in industrial Iot using a quantum informed artificial hummingbird optimization algorithm.","authors":"S Rajkumar, R Gopalakrishnan","doi":"10.1038/s41598-025-19358-z","DOIUrl":"10.1038/s41598-025-19358-z","url":null,"abstract":"In Industrial Internet of Things (IIoT), Clustering facilitates the proves of organizing similar types of devices or data points into different clusters for the objective of enhancing resource utilization, network management and data processing. This clustering in IIoT helps in addressing the challenges that are associated with the process of handling network complexity, satisfying requirements of real-time processing and dealing with massive data volumes. In specific, swarm intelligent optimization algorithms are used for selecting optimal CHs and determining reliable route through the network such that the parameters of data aggregation, delay and energy consumptions are handled with maximized performance. IIoT networks when blended with optimization algorithms-based clustering aids in improving scalability and energy efficiency which results in more cost-effective and reliable industrial applications. In this paper, Energy Efficient Quantum-Informed Artificial Hummingbird Optimization Algorithm (EEQIAHBOA) is proposed for maximizing the performance of IoT networks and addressing the energy preservation problem such that the information is gathered and sent to the base station for reactive decision making. This EEQIAHBOA approach is proposed as a reliable routing algorithm which is implementation with the determination of information heuristic factors and efficient encoding scheme. It is proposed as a significant clustering algorithm for the objective of achieving network lifetime such that the factors of residual energy, and distance between the cluster member IoT nodes and energy consumptions during the selection of Cluster Heads (CHs). The simulation experiments of EEQIAHBOA approach conducted with different network scenarios confirmed 32.12% improvement in energy efficiency and 35.62% enhancement in network lifetime under different live nodes compared to the baseline approaches used for investigation.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35485"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-derived macrophages. B细胞诱导的调节性T细胞可减弱小鼠骨髓源性巨噬细胞的经典M1极化。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19445-1

Yi-Ping Huang, Chien-Hui Chien, Li-Chieh Wang, Bor-Luen Chiang

{"title":"B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-derived macrophages.","authors":"Yi-Ping Huang, Chien-Hui Chien, Li-Chieh Wang, Bor-Luen Chiang","doi":"10.1038/s41598-025-19445-1","DOIUrl":"10.1038/s41598-025-19445-1","url":null,"abstract":"Regulatory T (Treg) cells are effective immunomodulators of adaptive and innate immune responses. Our previous studies have demonstrated that B-cell-induced CD4+Foxp3- regulatory T cells, referred to as Treg-of-B cells, exert suppressive capacity, by inhibiting CD4+CD25- T-cell proliferation and inflammasome activation. In the present study, Treg-of-B cells downregulated proinflammatory M1-like markers and partially induced M2-associated genes in unpolarized bone marrow-derived macrophages (BMDMs), as evidenced by RNA expression of Nos2, Arg1, Retnla, Mrc1, and Egr2. Treg-of-B cells decreased the RNA levels of Nos2, Tnfa, Cd86, and Cxcl9, and reduced the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and nitrite in LPS/interferon (IFN)-γ-stimulated M1-like macrophages in a dose-dependent manner. These cells also secreted Th2 cytokines, including IL-10, IL-4, and IL-13, with enhanced cytokine production observed when cocultured with macrophages. Mechanistically, Treg-of-B cells exerted their modulatory effects via both cell-cell contact and contact-dependent induction of soluble mediators, particularly Th2 cytokines. Furthermore, Treg-of-B cells promoted IκBα accumulation and suppressed RNA expression of Kruppel-like factor 4 (Klf4), thereby inhibiting NF-κB activation. These findings suggest that Treg-of-B cells regulate macrophage plasticity and might prevent excessive inflammation.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35537"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of predictors and outcomes following Vibrant Soundbridge implantation - part 1 of a prospective study. 动态音桥植入后的预测因素和结果的综合分析-前瞻性研究的第一部分。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-20966-y

Christoph Müller, Hannes Seidler, Anna Tsypina, Janina Kuch, Thomas Zahnert, Susen Lailach

{"title":"Comprehensive analysis of predictors and outcomes following Vibrant Soundbridge implantation - part 1 of a prospective study.","authors":"Christoph Müller, Hannes Seidler, Anna Tsypina, Janina Kuch, Thomas Zahnert, Susen Lailach","doi":"10.1038/s41598-025-20966-y","DOIUrl":"10.1038/s41598-025-20966-y","url":null,"abstract":"Active middle ear implants such as the Vibrant Soundbridge (VSB) represent effective treatment options for patients with conductive or mixed hearing loss when conventional hearing aids are insufficient. Nevertheless, postoperative speech intelligibility varies considerably, even among patients with comparable audiometric profiles. This first part of a two-part prospective observational study aimed to analyze outcomes and identify clinically accessible predictors of postoperative speech intelligibility. Twenty adults who underwent unilateral VSB implantation were included. Audiological assessments comprised postoperative bone conduction (BC), Vibrogram (VIB), free-field thresholds, maximum unaided speech intelligibility (WRSmax), and aided speech intelligibility at 65 dB SPL (WRS65dB). Additional parameters included coupling efficiency, effective gain, dynamic range, loudness scaling, and patient-reported outcomes (PROMs; IOI-HA, SSQ12). Key predictors of WRS65dB were identified using Spearman correlation analysis (ρ). The mean postoperative WRS65dB was 81.5% (SD = 9.0%). The strongest correlations were observed with age (ρ = - 0.63) and two surrogate parameters of cochlear reserve - WRSmax (ρ = 0.56) and postoperative BCPTA4 (ρ = - 0.52). PROMs confirmed high subjective benefit and displayed correlations with audiological outcomes. Age, WRSmax and postoperative BCPTA4 will serve as the basis for the AI-based prediction model presented in part II. The correlation of PROMs with audiological outcomes highlights the importance of integrating objective and subjective measures in hearing rehabilitation.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35403"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunnel enabled programmable switches obfuscate network topology to defend against link flooding reconnaissance in software defined networking. 隧道使能的可编程交换机混淆网络拓扑，以防御软件定义网络中的链路泛洪侦察。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19566-7

Xiang Li, Jungmin Lee, Junggab Son, Yeonjoon Lee

{"title":"Tunnel enabled programmable switches obfuscate network topology to defend against link flooding reconnaissance in software defined networking.","authors":"Xiang Li, Jungmin Lee, Junggab Son, Yeonjoon Lee","doi":"10.1038/s41598-025-19566-7","DOIUrl":"10.1038/s41598-025-19566-7","url":null,"abstract":"Recently, Software-Defined Networking (SDN) has emerged as an increasingly popular network paradigm due to its virtualization capabilities and flexibility. However, its robustness in link connectivity is threatened by Link Flooding Attacks (LFAs). To launch LFAs, adversaries use probing tools to infer network topologies and identify target links with bottlenecks. Thus, protecting SDN topologies against disclosure is crucial to ensure system security and preserve infrastructure functionality. We propose TEPS (Tunnel-Enabled Programmable Switches), a proactive defense system that dynamically obfuscates network topologies to defend against adversarial reconnaissance in SDN. TEPS generates false topologies by leveraging the flexibility of emerging programmable switches to construct customized tunnels and manipulate probing packets using the P4 language. This prevents adversaries from obtaining accurate knowledge of network topologies, making it difficult to reconstruct the true topologies. Furthermore, TEPS counters Round-Trip Time (RTT)-based fingerprinting attacks by dynamically adjusting packet delays and routing traffic to conceal RTT variations. Our evaluation demonstrates that TEPS effectively reduces the distribution of link importance in network topologies compared to the latest proactive defense method, thereby concealing bottlenecks and disrupting adversarial topology reconnaissance, including thwarting RTT-based fingerprinting attempts. Furthermore, by leveraging the capabilities of P4 switches, TEPS introduces minimal network overhead, with at most a 3% reduction in throughput and a 9.57% increase in resource utilization, showing practical feasibility under real-world operational constraints. By implementing TEPS, network administrators can enhance the security of their SDN infrastructures against LFAs and maintain robust connectivity through a lightweight approach.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35549"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors. 在胞嘧啶碱基编辑器中，UGI在Cas9内的重新定位减少了Cas9依赖的脱靶效应。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19482-w

Zehao Shi, Tian-Lin Cheng

引用次数: 0

Changing climate and its impacts on the dynamics of future malaria transmission over certain endemic regions in India. 气候变化及其对印度某些流行地区未来疟疾传播动态的影响。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-07971-x

Prasanta Kumar Bal, Divya Subash Kumar, Ruchi Singh Parihar, Atul Saini

{"title":"Changing climate and its impacts on the dynamics of future malaria transmission over certain endemic regions in India.","authors":"Prasanta Kumar Bal, Divya Subash Kumar, Ruchi Singh Parihar, Atul Saini","doi":"10.1038/s41598-025-07971-x","DOIUrl":"10.1038/s41598-025-07971-x","url":null,"abstract":"As climate change plays a major role in evaluating the malaria disease over India, it is highly relevant to assess the spatio-temporal variability of malaria transmission dynamics over different climatic zones in India using modelling studies. In this study, VECTRI (vector-borne disease community model of the International Centre for Theoretical Physics, Trieste) model is simulated to predict the future malaria transmission dynamics over four major climatological zones of India, forced with the different climatic parameters such as temperature and rainfall and non-climatic parameter such as population density. The climate data is obtained from multi model mean of different CMIP6 global climate models under the SSP5-8.5 scenario. Results indicate that there is an overall decrease in EIR (Entomological Inoculation Rate) values of 10 to 30% are seen over most of the Indian regions with an increase in temperature about 4 to 5 °C and rainfall about 10 to 40%, by end of the century (2080s) when compared with the baseline period (1985-2014). However, few exceptions are seen over few parts of western and peninsular region where increase in EIR values are seen. This decrease (increase) in EIR values which describes the intensity of malaria transmission is predominantly controlled by temperature and rainfall during summer (winter) monsoon seasons. Such results from the VECTRI model may be useful for policymakers towards various malaria disease control programs in India and this may provide a basis for climate change impact assessments on malaria risk at a regional scale.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35412"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12514050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0