Scientific Reports最新文献

{"title":"Insulator discharge severity assessment algorithm based on RDIDSNet.","authors":"Cheng Chi, Li Keyu, Yanhui Meng, Yang Yang, JiNing Zhao, Shaotong Pei, Haosen Sun","doi":"10.1038/s41598-025-97010-6","DOIUrl":"https://doi.org/10.1038/s41598-025-97010-6","url":null,"abstract":"<p><p>For the insulator discharge severity assessment at the line inspection site using edge-end computing equipment and UV cameras, this paper proposes an improved assessment algorithm based on the YOLOv8 algorithm. Firstly, LDConv is introduced to replace the convolution of the backbone network part of the network feature extraction, which effectively realizes the enhancement of the feature extraction ability of the algorithm in the case of model lightweighting; and then ACMix attention mechanism is introduced, which realizes better focusing of the model on the target with a very small performance loss; and finally, Shape-IoU is introduced to replace the loss function of the CIoU, which effectively improve the detection accuracy of the algorithm. The experimental results show that compared with the original YOLOv8, the RDIDSNet algorithm proposed in this paper achieves a detection speed of 61 Frames/s while realizing a detection accuracy of 78.1%, which can satisfy the demand for fast and accurate assessment of insulator discharge severity on edge devices.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11934"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking analyses on the chemical profile and antioxidant potential of Cakile maritima using GC-MS and HPLC.","authors":"Erdi Can Aytar, Emine Incilay Torunoglu, Abidin Gümrükçüoğlu, Alper Durmaz, Saleh Al-Farraj, Mika Sillanpää","doi":"10.1038/s41598-025-94887-1","DOIUrl":"https://doi.org/10.1038/s41598-025-94887-1","url":null,"abstract":"<p><p>This study investigates the phytochemical composition, antioxidant activity, and potential biological applications of the methanol extract obtained from the above ground of Cakile maritima. Antioxidant analyses revealed DPPH IC₅₀ = 642.52 ± 29.68 mg/mL, FRAP radical scavenging activity = 1093.89 ± 17.68 mg/mL, and ferrous ion chelation activity IC₅₀ = 68.51 ± 1.53 mg/mL. The total phenolic and flavonoid contents were determined as 32.23 ± 1.97 mg GAE/g and 32.02 ± 5.64 mg QE/g, respectively. GC-MS analysis identified significant compounds such as 1H-imidazole, 4,5-dimethyl (9.94%) and dianhydromannitol (8.84%), highlighting their antioxidant and biomedical potential. Phenolic profiling was performed using HPLC, revealing dominant compounds such as gallic acid (407.93 mg/L) and pyrogallol (579.9 mg/L), while rutin (219.6 mg/L) emerged as the most abundant flavonoid. Molecular docking studies indicated that rutin is the strongest inhibitor of the target protein (ΔG = -9.1 kcal/mol, Ki = 0.00467 μM), supported by its strong binding interactions. Acute toxicity evaluations revealed low to moderate toxicity for most compounds, with dianhydromannitol showing higher toxicity (LD₅₀ = 8 mg/kg). Cytotoxicity predictions demonstrated significant antitumor potential of compounds such as pyridine, dianhydromannitol, and 1H-imidazole, 4,5-dimethyl against various cancer cell lines, including brain gliomas and colon adenocarcinomas. These findings highlight the rich chemical diversity and promising therapeutic potential of C. maritima extract.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11937"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of faecal microbial transplantation on clinical outcome, faecal microbiota and metabolome in dogs with chronic enteropathy refractory to diet.","authors":"C G Vecchiato, M C Sabetti, C H Sung, F Sportelli, C Delsante, C Pinna, M Alonzo, D Erba, J S Suchodolski, R Pilla, M Pietra, G Biagi, F Procoli","doi":"10.1038/s41598-025-96906-7","DOIUrl":"https://doi.org/10.1038/s41598-025-96906-7","url":null,"abstract":"<p><p>Chronic enteropathy (CE) is a common complaint in canine gastroenterology. Recently, faecal microbiota transplantation (FMT) gained attention as a treatment strategy. However, the efficacy and long-term impact of FMT is still unclear. Clinical index (CIBDAI), faecal microbiota and metabolome were monitored in 20 CE dogs refractory to diet before (T0) and 3 months (T3) after FMT. Further data were retrospectively collected up to 1-year after FMT. Significant improvements were observed in CIBDAI, Dysbiosis Index (DI), and primary (PBAs) and secondary (SBAs) faecal bile acids and propionate one month (T1) after FMT (CIBDAI (median and range): T0 5 (1-9) vs. T1 1 (0-5), p < 0.0001; DI (median and range): T0 -0.1 (-5.6 to 3.8) vs. T1 -2.1 (-5.7 to 4.7), p < 0.05; PBAs decreased by 57%, SBAa increased by 41%; propionate increased by 20%). According to CIBDAI, 17 dogs clinically improved up to T3, and 10 dogs remained clinically stable up to one year after FMT. Alpha- and beta-diversity of the faecal microbiota of CE dogs did not differ, neither before nor after FMT, from that of 17 healthy controls. The results highlight that CE dogs refractory to diet with mild clinical signs and dysbiosis may benefit long-term from treatment with FMT.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11957"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-objective approach to load balancing in cloud environments integrating ACO and WWO techniques.","authors":"Umesh Kumar Lilhore, Sarita Simaiya, Yogendra Narayan Prajapati, Anjani Kumar Rai, Ehab Seif Ghith, Mehdi Tlija, Tarik Lamoudan, Abdelaziz A Abdelhamid","doi":"10.1038/s41598-025-96364-1","DOIUrl":"https://doi.org/10.1038/s41598-025-96364-1","url":null,"abstract":"<p><p>Effective load balancing and resource allocation are essential in dynamic cloud computing environments, where the demand for rapidity and continuous service is perpetually increasing. This paper introduces an innovative hybrid optimisation method that combines water wave optimization (WWO) and ant colony optimization (ACO) to tackle these challenges effectively. ACO is acknowledged for its proficiency in conducting local searches effectively, facilitating the swift discovery of high-quality solutions. In contrast, WWO specialises in global exploration, guaranteeing extensive coverage of the solution space. Collectively, these methods harness their distinct advantages to enhance various objectives: decreasing response times, maximising resource efficiency, and lowering operational expenses. We assessed the efficacy of our hybrid methodology by conducting extensive simulations using a cloud-sim simulator and a variety of workload trace files. We assessed our methods in comparison to well-established algorithms, such as WWO, genetic algorithm (GA), spider monkey optimization (SMO), and ACO. Key performance indicators, such as task scheduling duration, execution costs, energy consumption, and resource utilisation, were meticulously assessed. The findings demonstrate that the hybrid WWO-ACO approach enhances task scheduling efficiency by 11%, decreases operational expenses by 8%, and lowers energy usage by 12% relative to conventional methods. In addition, the algorithm consistently achieved an impressive equilibrium in resource allocation, with balance values ranging from 0.87 to 0.95. The results emphasise the hybrid WWO-ACO algorithm's substantial impact on improving system performance and customer satisfaction, thereby demonstrating a significant improvement in cloud computing optimisation techniques.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12036"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of information processing speed on memory processes in patients with relapsing-remitting and primary progressive multiple sclerosis.","authors":"Carolin Balloff, Sven G Meuth, Heinz Wiendl, Andreas Johnen, Jens Bölte, Iris-Katharina Penner, Nils C Landmeyer","doi":"10.1038/s41598-025-96181-6","DOIUrl":"https://doi.org/10.1038/s41598-025-96181-6","url":null,"abstract":"<p><p>Slowed information processing speed (IPS) is the primary cognitive impairment in people with multiple sclerosis (pwMS). Although it is known to affect memory processes, the relationships between verbal learning (VL), verbal memory (VM) and IPS in different phenotypes of multiple sclerosis (MS) remain underexplored. This bicentric study aimed to investigate in detail IPS, VL, and VM as well as the relationships between these cognitive domains in a large sample of 92 pwMS (61 with early relapsing-remitting MS (pwRRMS), 31 with primary-progressive MS (pwPPMS)) and 61 age-matched healthy controls (HC). Compared with HC, pwPPMS performed significantly worse on all cognitive measures, whereas pwRRMS performed worse than HC only on IPS and VL. Irrespective of phenotype, IPS impairment emerged as the core cognitive deficit in MS, affecting 25% of the RRMS group and 45% of the PPMS group. PwRRMS outperformed pwPPMS in all domains, with the most pronounced differences observed in VL. Isolated VL or VM impairments were rare, as most pwMS with these deficits also had concurrent IPS impairment. PwPPMS had significantly higher rates of IPS and VL impairment than pwRRMS, but not in VM. Regression analyses showed that IPS significantly predicted both VL and VM performance in both MS groups. In HC, IPS was only associated with VL performance, hinting at different cognitive mechanisms underlying the performance in this domain. This study provides evidence that pwPPMS experience more pronounced cognitive changes in IPS and VL compared to pwRRMS. It also highlights the pervasive impact of IPS on VL and VM performance in both subtypes, underscoring the importance of IPS-focused interventions in the management of MS-related cognitive dysfunction.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11978"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence.","authors":"Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Yanwu Liu, Xian Cheng, Meng Zhang, Wenqing Gao, Tong Li","doi":"10.1038/s41598-025-92328-7","DOIUrl":"https://doi.org/10.1038/s41598-025-92328-7","url":null,"abstract":"<p><p>Myocardial infarction (MI) has high morbidity and mortality, and the macrophage senescence-associated secretory phenotype (SASP) plays a central role in M1 healing. α-Lipoic acid (ALA) alleviates MI by regulating the function of macrophages, although the relationship between ALA and macrophage senescence remains unclear. To investigate macrophage SASP in MI, we performed single-cell RNA sequencing (scRNA-seq) on the GEO GSE163465 dataset, along with qPCR and western blot analyses to assess SASP expression in macrophages subjected to hypoxia and ALA treatment. Immunofluorescence was used to detect SASP distribution. Coculture and animal experiments were performed to assess the therapeutic effects of ALA on macrophage senescence and cardiomyocyte ischemic injury. scRNA-seq revealed an age-independent senescent propensity of macrophages in MI. Increased expression of H2A.X, CCL7, IL1β, and CDKN1A, along with decreased SOD2 expression, confirmed that macrophage SASP occurred after hypoxia, with oxidative stress and energy metabolism involved in the process. ALA inhibited the degradation of SIRT1 and promoted the Nrf2 nuclear translocation, alleviating macrophage senescence and myocardial ischemic injury. Age-independent macrophage SASP occurred during MI. Macrophage SASP was induced by ROS and mitochondrial dysfunction. ALA alleviated SASP by decreasing ROS generation and autophagy flux while increasing SIRT1 levels, and Nrf2 nuclear translocation. ALA ameliorated MI injury.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11996"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sampling-based winner determination model and algorithm for logistics service procurement auctions under double uncertainty.","authors":"Mingqiang Yin, Hao Wang, Qiang Liu, Xiaohu Qian, He Zhang, Xianming Lang","doi":"10.1038/s41598-025-94748-x","DOIUrl":"https://doi.org/10.1038/s41598-025-94748-x","url":null,"abstract":"<p><p>This paper studies the winner determination problem under disruption and demand uncertainty from the perspective of fourth-party logistics platform. To hedge risks brought by double uncertainty, a hybrid mitigation strategy that integrates temporary outsourcing strategy and fortification strategy is developed. With the objective of minimizing total cost, a new two-stage stochastic winner determination model under double uncertainty is constructed, which is further transformed into mixed-integer linear programming model by using an improved sample average approximation algorithm based on the chi-square test and the Latin hypercube sampling method. To address the challenges brought by numerous demand and disruption scenarios in model solving, combining dual decomposition Lagrangian relaxation algorithm and scenario reduction approach, a sampling-based heuristic algorithm is proposed. To validate the effectiveness of our model and algorithm, a real case and several numerical examples including cases generated by using the Combinatorial Auction Test Suite are provided. The results of numerical examples and real case indicate that the proposed algorithm has superior performance to CPLEX, validating the effectiveness of model and methods. Sensitivity analysis results show that demand fluctuations and the magnitude of disruption probability have significant impacts on the selection of risk response strategies.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12054"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study on the fragmentation of rock under single free face explosion of variable diameter decoupled charge.","authors":"Jiabing Lyu, Tiejun Tao, Caijin Xie","doi":"10.1038/s41598-025-96636-w","DOIUrl":"https://doi.org/10.1038/s41598-025-96636-w","url":null,"abstract":"<p><p>In the conventional radial uncoupled charge single free surface blasting, the bottom rock mass is difficult to be fully broken, which affects the blasting effect and restricts the tunneling efficiency. This difficulty adversely impacts the blasting outcome and limits the efficiency of excavation. To address this issue, this paper proposes a solution that involves modifying the charge structure to implement a variable diameter decoupled charge, and it analyzes the theoretical feasibility of this approach. The variably diameter decoupled charge and radial decoupled charge single-hole blasting model was established and compared using LS-DYNA. Furthermore, the effects of various parameters on the rock-breaking efficiency of variable diameter decoupled charges were analyzed. The results show that, in comparison to radially decoupled charges, variable diameter decoupled charges exhibit a greater explosive mass at their base. This enhancement leads to an increase in the effective stress on the surrounding rock, thereby effectively addressing the issue of inadequate fragmentation of the rock mass at the base of radially decoupled charges. Simultaneously, the directional effect of stress wave superposition and the balancing effect of the cavity on internal pressure contribute to an increase in the effective stress and reflected tensile stress of the overlying rock mass. This phenomenon ensures that effective fragmentation of the overlying rock mass can still be achieved, even with a relatively small amount of explosive charge. Under the condition of maintaining the same charge weight and borehole diameter, increasing the length and radius of the expanding section of the explosive significantly impacts rock fragmentation, whereas reducing the radius of the contracting section has a minimal effect. In engineering applications with a common borehole diameter of 4.2 cm, when the length of the expanding section of the explosive charge is half of the total charge length and the radius of the expanding section ranges from 1.65 cm to 1.70 cm, more effective rock fragmentation at the bottom can be achieved, resulting in an overall favorable fragmentation outcome.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11968"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human serum albumin or polyvinyl alcohol can only partially replace human plasma during in vitro red cell production from PBMC.","authors":"Marie-José A G Claessen, Nurcan Yagci, Gerard van Mierlo, Marie José Kersten, Marieke von Lindern, Emile van den Akker","doi":"10.1038/s41598-024-81341-x","DOIUrl":"https://doi.org/10.1038/s41598-024-81341-x","url":null,"abstract":"<p><p>Transfusion of donor-derived red blood cells (RBC) depends on donor availability. Alloimmunization can limit the availability of transfusion units, particularly for chronically transfused patients. In vitro cultured, customizable RBC (cRBC) would negate these concerns and provide infinite RBC products. Previously, we developed a defined medium based on good manufacturing practice (GMP) requirements. To optimize medium conditions with regards to reproducibility and cost effectiveness, we tested the requirement for plasma during the differentiation phase and the replacement of HSA by polyvinyl alcohol (PVA) during the expansion and differentiation phase. We show that 5% plasma is essential to enhance cell count, enucleation% and mostly stability of cRBC during the differentiation phase. During the expansion phase HSA could be replaced by PVA without compromising the expansion capacity. Substitution of HSA by PVA even increased the number of cells at the end of the expansion phase. During the differentiation phase PVA could also replace HSA, but only in the presence of plasma. Plasma is still essential to achieve an optimum yield of enucleated cRBC, likely by stabilizing enucleated cRBC. Substitution of HSA by PVA is a new advancement in the development of a, defined, cost-effective culture medium to culture cRBC for all.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12058"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties and longitudinal measurement invariance of the treatment-induced neuropathy assessment scale in the Chinese cancer chemotherapy population.","authors":"Yanfei Jin, Yang Li, Lina Xiong, Chulei Tang, Hongwen Ma","doi":"10.1038/s41598-025-96978-5","DOIUrl":"https://doi.org/10.1038/s41598-025-96978-5","url":null,"abstract":"<p><p>Treatment-induced peripheral neuropathy is one of the most complex toxicities to diagnose and manage in cancer patients. The severity and course of neuropathy across various cancer treatments are widely assessed using the Treatment-Induced Neuropathy Assessment Scale (TNAS). However, the psychometric properties and longitudinal measurement invariance of TNAS have not been evaluated in non-Western samples. The purpose of this study was to evaluate psychometric properties and longitudinal measurement invariance of the TNAS in Chinese cancer patients. A quantitative survey with a longitudinal design was used in this study. A total of 361 patients were included and data were collected at three-time points. Confirmatory factor analysis (CFA), convergent validity, longitudinal measurement invariance, criterion validity, and internal consistency reliability were evaluated. In this study, CFA supported the 2-factor structure of the original TNAS construct at three time points. The composite reliability (CR) and the average variance extracted (AVE) indicated that the TNAS had good convergent validity. Furthermore, TNAS exhibited strong measurement invariance over time with good reliability across different time points. The correlation between TNAS and EORTC QLQ-CIPN20 showed good criterion validity. Moreover, the TNAS and sub-scales had high internal consistency at three time points. Thus, TNAS is a reliable and valid instrument with adequate psychometric properties and temporal stability for measuring treatment-induced peripheral neuropathy and tracking changes in neuropathy symptoms.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11960"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}