Scientific Reports最新文献_第4页

A keyword-based approach to analyzing scientific research trends: ReRAM present and future.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-93423-5

Hyeon Kim, Seong Hun Kim, Jaeseon Kim, Eun Ho Kim, Jun Hyeong Gu, Donghwa Lee

{"title":"A keyword-based approach to analyzing scientific research trends: ReRAM present and future.","authors":"Hyeon Kim, Seong Hun Kim, Jaeseon Kim, Eun Ho Kim, Jun Hyeong Gu, Donghwa Lee","doi":"10.1038/s41598-025-93423-5","DOIUrl":"https://doi.org/10.1038/s41598-025-93423-5","url":null,"abstract":"Research trend analysis is a primary step in defining research structures and predicting research directions from scientific papers. Recently, due to millions of annual scientific publications, researchers demand analytical methods to interpret the research field topologically and temporally. In this study, we propose a keyword-based research trend analysis method that automatically and systematically analyzes the research field by extracting keywords and constructing a keyword network. We verified our method on the resistive random-access memory (ReRAM) research field, which is in the limelight as an alternative device for non-volatile memory and artificial synapses. Our method performs three sequential processes: article collection, keyword extraction, and research structuring. We identified three keyword communities of ReRAM based on the processing-structure-property-performance (PSPP) relationship and found an upward trend in Neuromorphic applications. As a result, our method successfully structures the ReRAM research field and is expected to provide detailed insights into various research fields.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12011"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tardive dyskinesia drug target VMAT-2 participates in neuronal process elongation.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-97308-5

Miki Ishida, Ryuya Ichikawa, Katsuya Ohbuchi, Hiroaki Oizumi, Yuki Miyamoto, Junji Yamauchi

{"title":"A tardive dyskinesia drug target VMAT-2 participates in neuronal process elongation.","authors":"Miki Ishida, Ryuya Ichikawa, Katsuya Ohbuchi, Hiroaki Oizumi, Yuki Miyamoto, Junji Yamauchi","doi":"10.1038/s41598-025-97308-5","DOIUrl":"https://doi.org/10.1038/s41598-025-97308-5","url":null,"abstract":"Tardive dyskinesia involves involuntary movements of body parts and is often observed in individuals taking antipsychotics for extended periods. Initial treatment strategies include reducing medication dosage, switching medications, or using drugs to suppress symptoms. One of the therapeutic targets for tardive dyskinesia is vesicular monoamine transporter-2 (VMAT-2, also known as solute carrier family 18 member A2 [SLC18A2]), which functions as an energy-dependent transporter of monoamines. The therapeutic drugs are used during adulthood, when neurons are maturing. For the first time, we report that treatment with a chemical VMAT-2 inhibitor reduces neuronal process elongation, a phenomenon commonly observed during development. Treatment with the inhibitors reserpine or tetrabenazine decreased process elongation in primary cortical neurons, and similar results were obtained in N1E-115 neuronal model cells undergoing process elongation. Knockdown of VMAT-2 using clustered regularly interspaced short palindromic repeat (CRISPR)/Cas13-fitted guide RNA also reduced process elongation. However, treatment with reserpine or tetrabenazine did not affect the morphology of mature processes. Notably, treatment with hesperetin, a citrus flavonoid with neuroprotective effects, was able to restore the reduced process elongation induced by these inhibitors or VMAT-2 knockdown. The underlying molecular mechanism appeared to involve neuronal differentiation-related Akt kinase signaling. These results suggest that VMAT-2, as a drug target for tardive dyskinesia, plays a key role in process elongation and that some inhibitory effects of VMAT-2-targeted drugs on its elongation may be mitigated by co-administering a neuroprotective molecule.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12049"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenetic study on three Metacineta species gives a new look at subclass Suctoria systematics.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-94558-1

Nikita Borodin, Maksim Melekhin, Chitchai Chantangsi

{"title":"Phylogenetic study on three Metacineta species gives a new look at subclass Suctoria systematics.","authors":"Nikita Borodin, Maksim Melekhin, Chitchai Chantangsi","doi":"10.1038/s41598-025-94558-1","DOIUrl":"https://doi.org/10.1038/s41598-025-94558-1","url":null,"abstract":"Suctoria is a subclass of ciliates (Phyllopharyngea, Suctoria) distinguished by the presence of a specialized feeding apparatus called tentacles and the absence of ciliature during most of their life cycle. This group of ciliates, particularly the order Exogenida, is poorly studied from a molecular phylogenetic perspective, with only a dozen small subunit (SSU) rRNA gene sequences available in public databases. In this study, we examined three species of suctorians from the genus Metacineta, formerly belonging to the order Exogenida. Using scanning electron microscopy and differential interference contrast microscopy, the examined species were redescribed and their SSU rRNA gene sequences were obtained. The morphological study refined the structural features of the calyx in representatives of the genus and a hypothetical scheme of calyx evolution was proposed based on morphological evidence and new molecular data. In addition, the application of an ultrastructural approach allowed clarification of the calyx structure in Metacineta alata, which possesses unique crests, instead of the typical clefts found in the majority of congeners. Our phylogenetic analysis showed that Metacineta is nested within the order Endogenida instead of clustering with the exogenid members. This new finding raises a question about the validity of the current classification system of the subclass Suctoria based on budding patterns and suggests necessity for a comprehensive reevaluation.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11983"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the COVID-19 pandemic on poisoning induced out of hospital cardiac arrest in South Korea retrospective observational study.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-87346-4

Young Taeck Oh, Chiwon Ahn, Yeonkyung Park, Jae Hwan Kim

{"title":"Impact of the COVID-19 pandemic on poisoning induced out of hospital cardiac arrest in South Korea retrospective observational study.","authors":"Young Taeck Oh, Chiwon Ahn, Yeonkyung Park, Jae Hwan Kim","doi":"10.1038/s41598-025-87346-4","DOIUrl":"https://doi.org/10.1038/s41598-025-87346-4","url":null,"abstract":"Poisoning-induced out-of-hospital cardiac arrest has characteristics distinct from cardiogenic out-of-hospital cardiac arrest, with external factors such as patient intent and environmental influences playing crucial roles. The coronavirus disease 2019 (COVID-19) pandemic has altered societal and healthcare dynamics, potentially influencing poisoning-induced out-of-hospital cardiac arrest outcomes. This study aimed to evaluate the impact of the pandemic on poisoning-induced out-of-hospital cardiac arrest characteristics and survival in South Korea. Participants: Adult patients (aged ≥ 19 years) who experienced poisoning-induced out-of-hospital cardiac arrest before and during the COVID-19 pandemic. This study utilized data from the Out-of-Hospital Cardiac Arrest Surveillance Database from 2016 to 2022. Poisoning-induced out-of-hospital cardiac arrest cases were compared before and during the pandemic by analyzing patient demographics, poisoning agents, prehospital interventions, and outcomes. Multivariate logistic regression identified predictors of survival. During the pandemic, poisoning-induced out-of-hospital cardiac arrest cases involving alcohol, organic solvents, and unspecified drugs increased, while pesticide-related cases declined. Bystander cardiopulmonary resuscitation rates rose, yet survival rates fell (adjusted OR 0.59, CI 0.44-0.80). Prehospital return of spontaneous circulation and witnessed arrests remained the strongest predictors of survival (adjusted OR 13.93 and 4.09, respectively). The COVID-19 pandemic initially impacted poisoning-induced out-of-hospital cardiac arrest outcomes, particularly during its early stages, while later outcomes showed resilience in the emergency medical system. These findings highlight the importance of adaptable public health strategies to address vulnerabilities during large-scale crises.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11959"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern synthesis of linear array antennas based on Chaos Triangular Pelican Optimization Algorithm.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-95855-5

Anyong Liu, Yan Liu, Zhuo Chen, Yibo Wang, Yurong Yin

引用次数: 0

Patients' knowledge, attitudes, and practices regarding lifestyle related dry eye. 患者对与生活方式相关的干眼症的认识、态度和做法。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-97290-y

Ke Song, Shanshan Ye, Shujiao Li, Ningling Wu, Zefeng Kang

{"title":"Patients' knowledge, attitudes, and practices regarding lifestyle related dry eye.","authors":"Ke Song, Shanshan Ye, Shujiao Li, Ningling Wu, Zefeng Kang","doi":"10.1038/s41598-025-97290-y","DOIUrl":"https://doi.org/10.1038/s41598-025-97290-y","url":null,"abstract":"Rising incidences of dry eye, often attributed to modern lifestyle and environmental factors, highlight the need for knowledge, attitudes, and practices (KAP) studies to inform tailored interventions. This study evaluated patients' KAP concerning lifestyle-related dry eye at the Ophthalmology Hospital of the China Academy of Chinese Medical Sciences from July 1 to July 26, 2024. A self-designed questionnaire was used to gather demographic data and assess KAP scores, yielding 556 valid responses (98.93%). Among participants, 342 (61.51%) were female, with a mean age of 39.26 ± 13.56 years. Mean KAP scores were 7.44 ± 4.65 (knowledge), 35.20 ± 4.10 (attitude), and 35.77 ± 6.15 (practice). Mediation analysis indicated direct influences of age and familial dry eye history on knowledge, with knowledge impacting attitude, and various factors influencing practice. While patients exhibited limited knowledge, they generally held positive attitudes and engaged in proactive practices. Enhancing patient education on lifestyle factors related to dry eye is essential to boost knowledge and foster effective prevention and management strategies.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12050"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute toxicity of mercury in response to metallothionein expression and oxidative and cellular metabolic stress in Barbonymus gonionotus.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-95697-1

Neeraj Kumar, Himanshu Priyadarshi, Janmejay Parhi, Pramod Kumar Pandey, Devendra Kumar

{"title":"Acute toxicity of mercury in response to metallothionein expression and oxidative and cellular metabolic stress in Barbonymus gonionotus.","authors":"Neeraj Kumar, Himanshu Priyadarshi, Janmejay Parhi, Pramod Kumar Pandey, Devendra Kumar","doi":"10.1038/s41598-025-95697-1","DOIUrl":"https://doi.org/10.1038/s41598-025-95697-1","url":null,"abstract":"Mercury (Hg) is one of the most harmful contaminates posing significant health risks to ecosystems worldwide. Fish, recognized for its affordability and accessibility, serves as a vital source of protein for the global population. To understand the impact of Hg exposure, an experiment was conducted using Barbonymus gonionotus (average weight: 9.64 ± 0.76 g) to determine the median lethal concentration (96 h-LC50) and the definitive dose of Hg. This study employed a static, non-renewable bio-assay to assess acute toxicity, using Hg concentrations of 0.3, 0.4, 0.5, 0.6, and 0.7 mg L⁻¹ in the definitive acute toxicity test. These concentrations were further evaluated for their effects on stress and cellular biomarkers, including metallothionein expression, oxidative stress indicators, histopathology, and bioaccumulation. Metallothionein (MT) expression in the liver was evaluated at 48 and 96 h, while oxidative stress markers were assessed in the liver, gill, kidney, and brain tissues. Additionally, glycolytic enzyme activity in the liver, gill, muscle, and kidney, as well as protein metabolic enzymes in the liver, gill, and kidney, were examined over the 96-hour exposure period to understand the effects of Hg at varying concentrations on B. gonionotus. Histopathological changes in the liver and gill and observed, along with the bioaccumulation of Hg in experimental water and different fish tissues. The study concluded that acute Hg exposure caused significant adverse effects on metallothionein expression, stress biomarkers, and the cellular and metabolic activities of B. gonionotus.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"12022"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual layer wideband angular stable frequency selective surface for linear to circular and circular to linear polarization conversion for 5G applications.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-96363-2

Akash Paramanik, Krishnamurthy Chitti Venkata, Venkatachalam Subramanian

引用次数: 0

An atomic clock synchronized versatile all-in-one digital 'LockBox'.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-90971-8

S Johnson, S Das Gupta, T R Saravanan, S Banerjee, S Majhi, S De

引用次数: 0

Seismic slope permanent displacement calculation based on improved Newmark model using upper bound solution of plastic mechanics.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2025-04-08 DOI: 10.1038/s41598-025-94895-1

Pengxu Jing, Wenbo Zheng, Li Li, Baokun Ning, Mingyong Lu, Qingyi Yang, Yanyun Nan, Jing Li, Yifan Xu, Jingjing Liu

{"title":"Seismic slope permanent displacement calculation based on improved Newmark model using upper bound solution of plastic mechanics.","authors":"Pengxu Jing, Wenbo Zheng, Li Li, Baokun Ning, Mingyong Lu, Qingyi Yang, Yanyun Nan, Jing Li, Yifan Xu, Jingjing Liu","doi":"10.1038/s41598-025-94895-1","DOIUrl":"https://doi.org/10.1038/s41598-025-94895-1","url":null,"abstract":"Based on a review of the fundamental principles of the Newmark sliding displacement method, this paper proposes an improved approach based on the upper bound solution of plastic mechanics, drawing on the theory of Academician Zuyu Chen, which states that \"during a given time period t, whenever velocity V > 0 occurs, the integration domain must be determined based on the varying distributions of acceleration a.\" The improved Newmark program integrates four main categories and eight subcategories of conditions into its framework through C + + programming. By employing the inclined strip method to construct velocity fields, the program enables more precise calculations of permanent slope displacements. To validate the effectiveness and accuracy of the improved method, calculations were conducted on both ideal slope models and real-world slope models. For the ideal soil and rock slope models, the results from the improved Newmark program were consistent with those obtained using the pseudo-static method and commercial software, demonstrating its strong applicability and accuracy. Furthermore, normalized artificial seismic waves, the Loma Prieta earthquake wave, and the Wenchuan earthquake wave, each with varying amplification factors, were input into the actual slope model of a colluvial deposit at the C1 hydropower station in Tibet. A comparison of these results with existing data revealed that the improved Newmark program produced calculations that closely matched real-world observations. This further validates the method's reliability and accuracy in practical applications. In conclusion, the improved Newmark program can more accurately calculate permanent displacements under seismic loads, which has far-reaching significance for the design and safety assessment of slope engineering.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11991"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0