Scientific Reports最新文献_第4页

A biomathematical model of SARS-CoV-2 in Syrian hamsters.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-18 DOI: 10.1038/s41598-024-80498-9

Sibylle Schirm, Geraldine Nouailles, Holger Kirsten, Jakob Trimpert, Emanuel Wyler, Luiz Gustavo Teixeira Alves, Markus Landthaler, Peter Ahnert, Norbert Suttorp, Martin Witzenrath, Markus Scholz

{"title":"A biomathematical model of SARS-CoV-2 in Syrian hamsters.","authors":"Sibylle Schirm, Geraldine Nouailles, Holger Kirsten, Jakob Trimpert, Emanuel Wyler, Luiz Gustavo Teixeira Alves, Markus Landthaler, Peter Ahnert, Norbert Suttorp, Martin Witzenrath, Markus Scholz","doi":"10.1038/s41598-024-80498-9","DOIUrl":"https://doi.org/10.1038/s41598-024-80498-9","url":null,"abstract":"When infected with SARS-CoV-2, Syrian hamsters (Mesocricetus auratus) develop moderate disease severity presenting key features of human COVID-19. We here develop a biomathematical model of the disease course by translating known biological mechanisms of virus-host interactions and immune responses into ordinary differential equations. We explicitly describe the dynamics of virus population, affected alveolar epithelial cells, and involved relevant immune cells comprising for example CD4+ T cells, CD8+ T cells, macrophages, natural killer cells and B cells. We also describe the humoral response dynamics of neutralising antibodies and major regulatory cytokines including CCL8 and CXCL10. The model is developed and parametrized based on experimental data collected at days 2, 3, 5, and 14 post infection. Pulmonary cell composition and their transcriptional profiles were obtained by lung single-cell RNA (scRNA) sequencing analysis. Parametrization of the model resulted in a good agreement of model and data. The model can be used to predict, for example, the time course of the virus population, immune cell dynamics, antibody production and regeneration of alveolar cells for different therapy scenarios or after multiple-infection events. We aim to translate this model to the human situation in the future.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"30541"},"PeriodicalIF":3.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Glacial summer paleohydrology across Central Europe.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-18 DOI: 10.1038/s41598-024-83189-7

Maximilian Prochnow, Johannes Hepp, Paul Strobel, Roland Zech, Sudip Acharya, Sönke Szidat, Damien Rius, Laurent Millet, Bruno Glaser, Michael Zech

{"title":"Late Glacial summer paleohydrology across Central Europe.","authors":"Maximilian Prochnow, Johannes Hepp, Paul Strobel, Roland Zech, Sudip Acharya, Sönke Szidat, Damien Rius, Laurent Millet, Bruno Glaser, Michael Zech","doi":"10.1038/s41598-024-83189-7","DOIUrl":"https://doi.org/10.1038/s41598-024-83189-7","url":null,"abstract":"It is generally accepted that a weakening of the North Atlantic thermohaline circulation caused the Younger Dryas cooling. Although the role of seasonality was emphasized previously, this aspect is rarely considered yet, and it remains elusive how this impacted hydroclimate during winters and summers across Central Europe. Here, we coupled biomarker-based δ18O and δ2H from Bergsee in southern Germany to reconstruct deuterium excess as a proxy for evaporation history from the Bølling-Allerød to the Preboreal. We compared this dataset with other biomarker isotope records in Central Europe. They are all lacking a strong isotopic depletion during the Younger Dryas, which is best explained by the summer sensitivity of the biomarker proxies: As Younger Dryas summers were relatively warm, there is an absence of the strong winter cooling signals recorded in annual water isotope records like Greenland or Lake Steißlingen. Lake evaporation at Bergsee together with other paleohydrological reconstructions draw a coherent picture of the Late Glacial hydroclimate, with strong evidence for warm and dry Younger Dryas summers. Rather than a southward shift of the Westerlies during winter, we suggest that a recently proposed feedback mechanism between North Atlantic sea ice extend, strong winter cooling and summer atmospheric blocking serves as a suitable explanation for summer dryness. Additional confidence to the robustness of these biomarker records is provided by the overall agreement of paleohydrological fluctuations during the Preboreal.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"30546"},"PeriodicalIF":3.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Predictive analytics of complex healthcare systems using deep learning based disease diagnosis model.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-82835-4

Muhammad Kashif Saeed, Alanoud Al Mazroa, Bandar M Alghamdi, Fouad Shoie Alallah, Abdulrhman Alshareef, Ahmed Mahmud

引用次数: 0

Author Correction: Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-83106-y

Dana Yelin, Nassem Ghantous, Muhammad Awwad, Vered Daitch, Talya Kalfon, Michal Mor, Shira Buchrits, Yair Shafir, Irit Shapira-Lichter, Leonard Leibovici, Dafna Yahav, Ili Margalit, Dorit Shitenberg

引用次数: 0

Author Correction: Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-82374-y

Mikhail G Dozmorov, Maggie A Marshall, Narmeen S Rashid, Jacqueline M Grible, Aaron Valentine, Amy L Olex, Kavita Murthy, Abhijit Chakraborty, Joaquin Reyna, Daniela Salgado Figueroa, Laura Hinojosa-Gonzalez, Erika Da-Inn Lee, Brittany A Baur, Sushmita Roy, Ferhat Ay, J Chuck Harrell

引用次数: 0

Author Correction: Assessment of solar energy potential for Bahir Dar city, Ethiopia.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-81464-1

Aschale Getnet Alemu, Tereche Getnet Tesfa, Assefa Beyene Ayalew, Ramesh Babu Nallamothu, Tewodros Semeneh Ayalew, Hailemariam Mulugeta Wassie

引用次数: 0

The diagnostic and predictive potential of lncRNA CASC2 targeting miR-155 in systemic lupus erythematosus patients with nephritis complication.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-81212-5

Nada R Mohamed, Abeer L Abd El-Fattah, Olfat Shaker, Ghadir A Sayed

{"title":"The diagnostic and predictive potential of lncRNA CASC2 targeting miR-155 in systemic lupus erythematosus patients with nephritis complication.","authors":"Nada R Mohamed, Abeer L Abd El-Fattah, Olfat Shaker, Ghadir A Sayed","doi":"10.1038/s41598-024-81212-5","DOIUrl":"https://doi.org/10.1038/s41598-024-81212-5","url":null,"abstract":"Lupus nephritis (LN) is a serious problem that results from systemic lupus erythematosus (SLE) complications. Recent studies have highlighted that non-coding RNA (ncRNA) dysregulation is a notable feature in patients with SLE. As a result, this research was designed to investigate lncRNA CASC2 and miR-155 levels as non-invasive diagnostic biomarkers in SLE patients, including those with and without nephritis, and to investigate their effectiveness in assessing disease severity and predicting LN. Our study included 60 patients with SLE who were subclassified into (30 non-LN and 30 LN groups), along with 30 control subjects. Quantification of lncRNA CASC2 and miR-155 in serum samples from the Egyptian population was carried out with real-time polymerase chain reaction (RT-PCR). The disease activity index (SLEDAI) for SLE was evaluated, and the analysis of the receiver operating characteristic (ROC) curve was implemented. Increased levels of lncRNA CASC2 were observed in SLE patients compared to healthy controls, with even higher levels observed in the LN group versus the non-LN patients' group. Conversely, miR-155 was noted to be down-regulated in SLE patients relative to controls, and its levels were lower in the LN group relative to the non-LN patients' group. The elevated expression of lncRNA CASC2 and reduced expression of miR-155 were both correlated to the severity of the disease. The current study illustrated that both lncRNA CASC2 and miR-155 could act as valuable non-invasive diagnostic biomarkers for SLE and predicting LN among SLE patients, as well as their abilities to detect the disease severity and progression.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"30537"},"PeriodicalIF":3.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new verification approach for nowcasting based on intensity and spatial-temporal feature correction.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-82182-4

Jun Liu, Tong Zhang, Yuanzhao Chen, Rui Wang, Mingjie Wang, Shuxin Wang, Ting Xu, Chunyang Zhao, Xunlai Chen

{"title":"A new verification approach for nowcasting based on intensity and spatial-temporal feature correction.","authors":"Jun Liu, Tong Zhang, Yuanzhao Chen, Rui Wang, Mingjie Wang, Shuxin Wang, Ting Xu, Chunyang Zhao, Xunlai Chen","doi":"10.1038/s41598-024-82182-4","DOIUrl":"https://doi.org/10.1038/s41598-024-82182-4","url":null,"abstract":"Forecast verification is very important in the nowcasting operation and technical development of strong convective weather. The current conventional verification method for nowcasting uses a binary classification event verification method, which exists with double punishment, leading to low scoring issues. In order to make up for the shortcomings of conventional verification methods and explore the potential value of forecasting, based on the characteristics and requirements of strong convective weather nowcasting operations, this paper proposes a neighborhood verification method that considers spatial scale, time scale, and intensity error information simultaneously, based on the spatial neighborhood fraction skill score (FSS) verification method. The paper designs an intensity neighborhood correction scheme, a time neighborhood correction scheme, and a comprehensive correction scheme that considers both intensity and time neighborhoods. By introducing spatial neighborhood probability, the strict spatial matching requirement is weakened. Based on the Gaussian membership function in fuzzy logic, the value of forecasting grid below the threshold is explored. Time neighborhood adaptive weighting strategy is adopted to solve the problem of early and delayed forecasts. The evaluation and verification of the optical flow radar extrapolation nowcasting results show that compared to the traditional \"point-to-point\" verification indicators, the proposed indicators can increase the tolerance of verification, provide more useful information, and are more in line with the needs of practical application.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"30531"},"PeriodicalIF":3.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Impact of Diagnosis-Related Groups (DRG) reform on cost homogeneity of treatment for patients with malignant tumours.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-82652-9

Xinyue Zheng, Xiaoyue Xiao, Keyi Shen, Tong Pei, Xinhao Lin, Wen Liu, Dan Wu, Xuehui Meng

引用次数: 0

Magnetic properties of quenched binary and ternary quasicrystal approximants.

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-12-17 DOI: 10.1038/s41598-024-81987-7

Fernand Denoel, Takayuki Shiino, Yu-Chin Huang, Girma Hailu Gebresenbut, Cesar Pay Gómez, Roland Mathieu

引用次数: 0