Scientific Reports最新文献

{"title":"Efficacy and safety of rituximab in anti-MuSK myasthenia Gravis: a systematic review and meta-analysis.","authors":"Siripong Chayanopparat, Perasin Banyatcharoen, Jiraporn Jitprapaikulsan, Ekdanai Uawithya, Natnasak Apiraksattayakul, Vasinee Viarasilpa","doi":"10.1038/s41598-025-90937-w","DOIUrl":"https://doi.org/10.1038/s41598-025-90937-w","url":null,"abstract":"<p><p>This systematic review and meta-analysis evaluated the effectiveness and safety of rituximab in patients with myasthenia gravis harboring antibodies to muscle-specific kinase (anti-MuSK). Four databases were searched from inception to December 23, 2023. We included adult patients (aged ≥ 18 years) who were diagnosed with anti-MuSK myasthenia gravis and who received rituximab. The outcomes assessed were the proportions of patients who achieved minimal manifestations or better and those who achieved complete stable remission or pharmacologic remission, according to the Myasthenia Gravis Foundation of America Postintervention Status (MGFA-PIS) scale at the last follow-up. Additional outcomes were mean glucocorticoid dose reduction and severe adverse events. Twelve studies with 111 participants were included. Overall, 82% (95% CI, 71‒91%; I² = 30.12%, P = 0.15) of patients achieved MGFA-PIS minimal manifestations or better, and 56% (95% CI, 45‒67%; I² = 0.00%, P = 0.60) achieved MGFA-PIS complete stable remission or pharmacologic remission. The mean reduction in the glucocorticoid dose was 17.15 mg (95% CI, 11.77‒22.53; I² = 32.40%, P = 0.19). Only one patient developed osteomyelitis during rituximab treatment. This study demonstrated that rituximab is a safe and effective treatment for anti-MuSK myasthenia gravis, helping patients achieve minimal manifestations, complete stable remission, or pharmacologic remission with minimal serious adverse events.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7219"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDEM numerical simulation of size effect on mechanical properties of basalts with hidden microcracks.","authors":"Yi Enbing","doi":"10.1038/s41598-025-91722-5","DOIUrl":"https://doi.org/10.1038/s41598-025-91722-5","url":null,"abstract":"<p><p>As an important geological environment medium for engineering construction in southwest China, basalt generally contains hidden microcracks at a micro-scale, which leads to significant size effect on its mechanical properties, and relevant research is lacking and unsystematic. A synthetic rock mass model based on the combination of a micro-discrete fracture network method and a finite-discrete element method is used to systematically explore the size effect of the mechanical properties of basalt rock blocks with hidden microcracks. The results showed that: (1) the fracture angle is uniformly distributed, and the fracture length conforms to the logarithmic normal distribution, with an areal fracture intensity P20 of 0.00025/mm² and P21 of 0.012 mm/mm². (2) According to the variation trends of mechanical parameters with the increase in the specimen dimension, the REV size of basalt rock blocks with hidden microcracks is determined to be 0.5 m. The mechanical properties obtained at this size are considered equivalent continuum properties and could be used as input parameters of rock blocks in complete rock mass or jointed rock mass for the numerical analysis at an engineering scale. (3) With the increase in the sample dimension, basalt changes from a small-sized complete sample to a medium-sized sample with local defects and then to an REV-sized sample with sufficient defects, the stress-strain curve characteristics under Brazilian disc splitting change from a single-peak shape to a zigzag shape and then to a multi-peak shape, and the failure modes changes from a single-center splitting failure mode to a local structure-controlled failure mode and then to a multi-center splitting failure mode, with the gradual decrease in the brittleness degree. The research results further enrich and improve the basic theory and technical methods of multi-scale analysis of geotechnical engineering, and provide strong scientific and technological support for the safety construction of deep engineering.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7246"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of LIN7A silencing on U87 cell invasion and its clinical significance in glioblastoma.","authors":"Xiaojuan Lyu, Yuxiang Shi, Daixu Wang, Xing Cao, Jipeng Guo, Guodong Huang, Lin Zhou, Mengxian Zhang, Zhen Dong","doi":"10.1038/s41598-025-91285-5","DOIUrl":"https://doi.org/10.1038/s41598-025-91285-5","url":null,"abstract":"<p><p>Glioblastoma is highly aggressive and resistant to treatment, making it crucial to understand the regulatory mechanisms underlying its invasion. LIN7A, a polar protein, has been implicated in tumor cell migration and invasion, but its role in glioblastoma remains unclear. This study aimed to manipulate LIN7A gene expression in U87 cells, analyze its impact on invasion, and explore the potential mechanisms through which LIN7A regulates glioblastoma cell invasion. Lentiviral vectors were used to silence the LIN7A gene in U87 cells, selecting the most effective vector. LIN7A gene transcription, protein expression and localization were analyzed using RT-qPCR, Western blotting, and immunofluorescence. U87 cell invasion was assessed via real-time cell analysis and spheroid invasion assay, while MMP-2 and MMP-9 protease activities were measured using zymography. β-catenin protein levels and localization were evaluated through Western blotting and immunofluorescence. Expression of target genes in the β-catenin pathway was also measured. An orthotopic xenograft glioblastoma model in nude mice was established by intracranial implantation of U87 cells, with tumor growth monitored using immunofluorescence analysis of brain slices. The clinical significance of LIN7A expression was confirmed by comparing its levels in core and peripheral invading areas of glioblastoma and analyzing RNASeq data and clinical information from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) GBM cohort. Transfection of U87 cells with a lentiviral vector led to decreased LIN7A levels and altered distribution patterns. Silencing the LIN7A gene increased U87 cell proliferation and invasiveness, reduced clonal formation ability, and enhanced MMP-2 and MMP-9 protease activity. It also resulted in a slight increase in cytoplasmic β-catenin content, although not statistically significant, but a significant increase in nuclear β-catenin accumulation and transcriptional activity of target genes in the pathway. Animal studies showed that LIN7A gene silencing caused U87 cells to transition from clumpy to invasive growth mode. LIN7A expression was significantly lower in the peripheral invading area compared to the core area in clinical samples of glioblastoma. Data mining of the CPTAC-GBM cohort revealed a strong association between LIN7A gene expression and survival time. Silencing LIN7A may promote U87 tumor cell invasion by disrupting intercellular junctions, altering cell polarity, and activating the β-catenin pathway. Further research is warranted to elucidate the role of LIN7A in glioblastoma cell invasion.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7212"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A customized bed based stand alone array of optically pumped magnetometers for fetal magnetocardiography measurements.","authors":"Diana Escalona-Vargas, Alberto Ramirez, Eric R Siegel, Elijah H Bolin, Hari Eswaran","doi":"10.1038/s41598-025-90846-y","DOIUrl":"https://doi.org/10.1038/s41598-025-90846-y","url":null,"abstract":"<p><p>Fetal magnetocardiography (fMCG) is a non-invasive technique that measures the magnetic fields associated with fetal heart electrical activity outside of the maternal abdomen. fMCG has high temporal precision for measuring fetal heart rate and its variability which reflects fetal neurodevelopment. Free of cryogenics and low-cost sensors called microfabricated optically pumped magnetometers (OPMs) have emerged as an alternate to cryogenic SQUID (Superconducting Quantum Interference Device) systems to record fMCG. Previous research has demonstrated the ability of the OPMs to measure the fMCG at different maternal positions by taking the advantage of the conformal and geometric flexibility of the sensors. In this work, we designed and configured a bed-based stand-alone array of OPMs to obtain serial recordings of fMCG. 72 combined OPM-SQUID recordings were conducted at different gestational ages in 22 pregnant women. We were able to obtain fMCG with similar detectability as the gold standard SQUID from OPM sensors mounted on a novel belly-shape patient interface design with movable sensor holders. While additional translational research is needed, the outcome of this study can further facilitate the development of a non-cryogenic low-cost smaller footprint device to increase the use of OPMs for fetal research and clinical applications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7236"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenic cell death signature predicts survival and reveals the role of VEGFA + Mast cells in lung adenocarcinoma.","authors":"Meng Zhang, Guowei Zhou, Yantao Xu, Benliang Wei, Qian Liu, Guanxiong Zhang, Ruimin Chang","doi":"10.1038/s41598-025-91401-5","DOIUrl":"https://doi.org/10.1038/s41598-025-91401-5","url":null,"abstract":"<p><p>Lung cancer is prevalent worldwide and is a major cause of cancer-related mortality. Despite being the primary model for immunotherapy research, the response rates of lung cancer patients to immunotherapy are unsatisfactory. Furthermore, research on immunogenic cell death (ICD) in lung cancer is limited, which limits the development of strategies that combine ICD-related therapies with immunotherapy. In this study, we compiled and summarized 69 genes associated with ICD and developed an IRS. Across seven independent datasets, the IRS was identified as an independent prognostic factor. IRS was positively associated with multiple tumor proliferation pathways and negatively associated with immune-related pathways. Additionally, IRS negatively correlated with the infiltration of various immune cells, supporting its association with survival outcomes. Based on the correlation between IRS and immune activity, we validated the ability of IRS to predict immunotherapy efficacy across seven immunotherapy datasets and demonstrated that patients who respond to immunotherapy tend to have a lower IRS. Moreover, utilizing single-cell RNA sequencing, we revealed the role of mast cells in the TME with the highest IRS. Through interactions with various receptors on macrophages, endothelial cells, and tumor cells, mast cells promote tumor progression, providing a comprehensive explanation for poor prognosis and lack of response to immunotherapy in patients with high IRS. Our study offers new guidance for combination therapies in lung adenocarcinoma patients and elucidated the mechanism by which mast cells contribute to cancer development within the TME.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7213"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AgRP neurons shape the sperm small RNA payload.","authors":"Iasim Tahiri, Sergio R Llana, Francisco Díaz-Castro, Marc Claret, Arnaud Obri","doi":"10.1038/s41598-025-91391-4","DOIUrl":"https://doi.org/10.1038/s41598-025-91391-4","url":null,"abstract":"<p><p>Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons in mice to simulate obesity's effects, we observed changes in the small noncoding RNA payload of sperm. These alterations, particularly in transfer RNA-derived small RNAs (tsRNAs), are similar to those induced by short-term high-fat diets, suggesting a common upstream regulatory mechanism involving AgRP neurons that affects metabolic epigenetic inheritance.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7206"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using tide for rainfall runoff simulation with feature projection and reversible instance normalization.","authors":"Zheng Fang, Simin Qu, Xiaoqiang Yang, Ziheng Li, Peng Shi, Xinjie Xu, Yu Yu","doi":"10.1038/s41598-025-91219-1","DOIUrl":"https://doi.org/10.1038/s41598-025-91219-1","url":null,"abstract":"<p><p>From LSTMs (Long Short-Term Memory) to Transformers, various networks have been used for runoff forecasting, though many complex structures may be unnecessary. This study introduces RR-TiDE, a simple model based on the Time Series Dense Encoder. RR-TiDE employs fully Multilayer Perceptron architecture for modeling and is specifically designed with understanding of hydrological processes. To manage non-stationarity in hydrological data, RR-TiDE incorporates Reversible Instance Normalization. The model was trained using the Catchment Attributes and Meteorology for Large-Sample Studies (CAMELS) dataset and evaluated on two tasks: (1) multi-basin runoff simulation; (2) prediction in data-sparse basins. In the first task, RR-TiDE outperformed both Transformer and LSTM-based models across all metrics for 7-day runoff predictions, which indicates that RR-TiDE is highly suitable for rainfall-runoff simulation. In the second task, it achieved a median NSE of 0.82 in 1-day runoff forecasting in 51 watersheds. This suggests that RR-TiDE possesses robust generalization capability, enabling spatial extrapolation. Comparisons were made between models with and without the feature projection layer and RevIN to further understand their individual contributions. Results indicate that the feature projection layer can effectively enhance the performance of RR-TiDE. Although RevIN provided limited overall improvements, it helped stabilize loss fluctuations during training, aiding model convergence.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7200"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin levels and chronic kidney disease and the subsequent risk of cardiovascular events: A long term population based cohort study.","authors":"Ehsan Rojhani, Maryam Rahmati, Faegheh Firouzi, Pardis Ziaeefar, Saber Amanollahi Soudmand, Fereidoun Azizi, Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani","doi":"10.1038/s41598-025-87783-1","DOIUrl":"https://doi.org/10.1038/s41598-025-87783-1","url":null,"abstract":"<p><p>Both the clearance and secretion of prolactin are disrupted in chronic kidney disease (CKD). Evidence indicates that prolactin may play a role in cardiovascular (CV) disturbances. Considering the increased cardiovascular risk associated with CKD, this study investigates the relationship between prolactin levels, CKD, and the risk of CV events in both women and men, with an average follow-up period of 20 years. The study included 2,005 participants from the Tehran Lipid and Glucose Study (TLGS) who met the inclusion criteria. They were reassessed approximately every three years for a median follow-up of 19.0 years (Interquartile range (IQR):16.4-20.2), during which occurrences of CKD and CV events were recorded. A pooled logistic regression model examined the influence of Prolactin on CV events and its interaction with CKD. During follow-up, we identified 156 incident cases of CV events among men and 73 among women. Median (95%CI) PRL levels were 7.4 (5.5-10.5) ng/mL for men and 15.2 (10.3-23) ng/mL for women. The results of analyses showed that a history of CKD was associated with significantly higher odds of CV events for both men 4.2 (95% CI: 2.6-6.8) and women 5.5 (95% CI: 2.6-11.5). Results remained unchanged after adjustment for confounders including age, waist circumference, smoking, education, history of diabetes and hypertension, and family history of CV events. Interaction analyses revealed no statistically significant interaction between CKD and PRL on the odds of CV events in unadjusted and adjusted models. This consistent pattern was observed regardless of gender. Results of population-based data with over a median follow-up period of 20 years showed that CKD independently increases the risk of CV events in both men and women. However, our findings suggest that this elevated risk may not be substantially influenced by prolactin levels. Further investigation may be warranted to confirm these findings.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7198"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photo and electrochemical applications of green synthesized ZnO/Ag₂O nanocomposites materials under visible light using P. macrosolen L. leaf.","authors":"Abel Saka Gungure, Leta Tesfaye Jule, Krishnaraj Ramaswamy, N Nagaprasad, Shanmugam Ramaswamy","doi":"10.1038/s41598-025-87777-z","DOIUrl":"https://doi.org/10.1038/s41598-025-87777-z","url":null,"abstract":"<p><p>This study investigates the photo-catalytic and super-capacitive properties of green-synthesized ZnO/Ag₂O nanocomposites using P. macrosolen L. leaf extract. The synthesis was performed in a single step at low temperature with a short reaction time. The synthesized materials were characterized using XRD, SEM, TEM, FTIR, UV-VIS and XPS. The ZnO/Ag₂O nanocomposites exhibited exceptional photo-catalytic efficiency and stability under visible light for the degradation of carbon-based dyes. The degradation rate constants of the optimized ZnO/Ag₂O nanocomposites were 0.054351 min⁻¹ for Methylene Orange (MO) and 0.048751 min⁻¹ for Toluidine Blue (TB), achieving degradation efficiencies of 99.69% and 98.50%, respectively, compared to ZnO (0.0075 min⁻¹). This remarkable improvement in visible-light photo-catalytic performance is attributed to the hetero-junction formation, which enhances charge separation and transfer through the matched crystal lattices and energy bands of Ag₂O and ZnO. The Ag₂O nanoparticles efficiently generate and transfer excited electrons to the ZnO conduction band under visible-light irradiation. Electrochemical studies revealed a significant improvement in specific capacitance, with the ZnO/Ag₂O composite containing 50 wt% AgNO₃ achieving a maximum specific capacitance of 655.0 F/g at a scan rate of 10 mV/s. This superior performance highlights the synergistic effect of ZnO and Ag₂O in improving photo-catalytic and electrochemical properties. These findings demonstrate the potential of ZnO/Ag₂O nanocomposites for industrial dye degradation and super-capacitor applications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7234"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the optimal scheduling of a multi-storage combined integrated energy system based on an energy supply grading strategy.","authors":"Na Zhang, Feng You, Bingqian Hu, Jingyu Li, Guangchen Liu","doi":"10.1038/s41598-025-89379-1","DOIUrl":"https://doi.org/10.1038/s41598-025-89379-1","url":null,"abstract":"<p><p>As an important supporting technology for carbon neutrality strategy, the combination of an integrated energy system and hydrogen storage is expected to become a key research direction. To address the insufficient flexibility of multi-energy coupling in the integrated energy system and the overall strategic demand of low-carbon development, a multi-storage integrated energy system architecture that includes electric storage, heat storage and hydrogen storage is established. Then, according to the system status factors, such as energy cost, response characteristics and energy storage status, a hierarchical energy supply control strategy focusing on the energy supply priority of energy storage units is proposed. NSGA-II-MOABC is created as the optimization algorithm to meet the demand of multi-energy coupling energy supply in the integrated energy system. Next, considering the system operational cost and carbon emission cost as the optimization goal, a comprehensive energy optimization scheduling model of multi-storage combined hierarchical energy supply is constructed. Based on the simulation example, the scheduling results of the multi-storage combined system are obtained, through comparative analysis, the addition of hydrogen storage can effectively improve the flexibility of system scheduling. Then, taking several scenarios as simulation examples, the hierarchical energy supply strategy can effectively reduce the system operation cost and carbon emission cost, and it also has a certain role in realizing the local consumption of renewable energy.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7184"},"PeriodicalIF":3.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}