Scientific Reports最新文献

{"title":"Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers.","authors":"Ragnar P Kristjánsson, Jojo Biel-Nielsen Dietz, Ólafur B Davíðsson, Bertram Kjerulff, Klaus Rostgaard, Joseph Dowsett, Signe Holst Søegaard, Emelie Curovic Rotbain, Michael Schwinn, Kristoffer Sølvsten Burgdorf, Jakob Thaning Bay, Christina Mikkelsen, Henrik Ullum, Søren Brunak, Erik Sørensen, Bitten Aagaard Jensen, Mie Topholm Bruun, Mette Nyegaard, Sisse Rye Ostrowski, Ole Birger Pedersen, Christian Erikstrup, Thomas Folkmann Hansen, Henrik Hjalgrim","doi":"10.1038/s41598-025-95276-4","DOIUrl":"https://doi.org/10.1038/s41598-025-95276-4","url":null,"abstract":"<p><p>Infectious mononucleosis (IM), predominantly caused by primary Epstein-Barr virus (EBV) infection, is a common disease in adolescents and young adults. EBV infection is nearly ubiquitous globally. Although primary EBV infection is asymptomatic in most individuals, IM manifests in a subset infected during adolescence or young adulthood. IM occurrence is linked to sibship structure, and is associated with increased risk of multiple sclerosis, other autoimmune diseases, and cancer later in life. We analyzed 47 biomarkers in 5,526 Danish individuals aged 18-60 years, of whom 604 had a history of IM, examining their associations with IM history up to 48 years after IM diagnosis. No significant long-term associations were observed after adjusting for multiple comparisons. When restricting the analysis to individuals measured within 10 years post-IM diagnosis, a statistically significant increase in CRP levels was observed in females. This association was not driven by oral contraceptive use. No significant associations between sibship structure and biomarker levels were detected. In conclusion, our study shows that while IM may lead to a transient increase in CRP levels in females, it does not result in long-term alterations in plasma biomarkers related to immune function, suggesting other mechanisms may be responsible for the long-term health impacts associated with IM.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11312"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging machine learning for prediction and optimization of texture properties of sustainable activated carbon derived from waste materials.","authors":"Ahmed Farid Ibrahim, Mohamed Abdrabou Hussein","doi":"10.1038/s41598-025-95061-3","DOIUrl":"https://doi.org/10.1038/s41598-025-95061-3","url":null,"abstract":"<p><p>The increasing demand for sustainable waste management has driven innovation in the production of activated carbon (AC) from waste. AC's textural properties, including its surface area (SA), total pore volume (TPV), and micropore volume (MPV), are critical for applications such as gas purification and wastewater treatment. However, the traditional assessment methods are expensive and complex. This study employed machine learning (ML) models to predict AC's properties and optimize its production process. Random Forest (RF), Decision Tree (DT), Gradient Boosting Regressor (GBR), support vector machines (SVM), and Artificial Neural Networks (ANN) were applied along with key input parameters, including raw material type, particle size, and activation conditions. A genetic algorithm (GA) integrated with the GBR model optimizes the synthesis process. The ML models, particularly RF and GBR, accurately predicted SA with R² values exceeding 0.96. In contrast, the linear regression models were inadequate, with R² values below 0.6, emphasizing the non-linear relationship between the inputs and outputs. Sensitivity analysis showed that the activation temperature, ratio of the activating agent to carbon, and particle size significantly affected the AC properties. Optimal properties were achieved under activation temperatures between 800 and 900 °C and activating-agent to the carbon ratio 3.8. This approach provides a scalable solution for enhancing AC production sustainability, while addressing critical waste management challenges.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11313"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of surface inclination and gluteus maximus activation on lumbar lordosis and footpronation in individuals with low back pain with extension pattern: a preliminary study.","authors":"Ryan K K Chan, Eric M F Choi, Crystal Y Y Chou, Alvin K Lam, Eliza R Sun, Patrick W H Kwong, Clare C W Yu, Sharon M H Tsang","doi":"10.1038/s41598-025-96048-w","DOIUrl":"https://doi.org/10.1038/s41598-025-96048-w","url":null,"abstract":"<p><p>Lumbar hyperlordosis and foot overpronation are associated with low back pain with extension pattern. This study examined if standing and walking on inclined surface or gluteus maximus activation alleviates the extent of lumbar lordosis and foot pronation amongst individuals with LBP who were classified with extension pattern. Eighteen adults with foot overpronation (LBP group, n = 9 and non-LBP group, n = 9) participated in this cross-sectional and case-control comparison study. Lumbar lordotic angle and rearfoot angle were measured using surface tomography, during standing and walking on treadmill at inclinations of 0°, 6° and 9°, and voluntary gluteus maximus activation at 20%, 40% and 60% of maximal contraction in standing at 0° inclination. The lumbar lordosis angle and rearfoot angle were compared within-group and between two groups across the listed trials in standing and walking. Results indicated no significant change in lumbar lordosis or rearfoot angle in LBP group when standing or walking on 6°or 9°inclined surface (p > 0.05). However, voluntary gluteus maximus activation in standing at the level of 20%, 40% and 60% of maximal effort reduced lumbar lordotic angle (p < 0.05) but not rearfoot angle (p > 0.05) in LBP group. Our findings provide a novel approach to address the hyperlordosis in LBP group with extension pattern, for which voluntary gluteus maximus activation of ≥ 20% of maximal effort could effectively reduce the extent of the lumbar lordosis in level-ground standing in the LBP group. Such modified lumbar posture may alleviate the compressive loading on the spine associated with static upright standing at our daily activities. Increased gluteus maximus activation found during inclined walking may be beneficial to those with LBP and extension pattern.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11242"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LSTM-JSO framework for privacy preserving adaptive intrusion detection in federated IoT networks.","authors":"Shaymaa E Sorour, Mohammed Aljaafari, Amany M Shaker, Ahmed E Amin","doi":"10.1038/s41598-025-95966-z","DOIUrl":"https://doi.org/10.1038/s41598-025-95966-z","url":null,"abstract":"<p><p>The rapid proliferation of Internet of Things (IoT) systems has created unprecedented opportunities for smart environments and introduced critical cybersecurity vulnerabilities. Existing intrusion detection systems often fail to address sophisticated distributed attacks, such as botnets and Distributed Denial of Service (DDoS), due to their reliance on centralized data and static configurations. This research introduces a novel framework that enhances intrusion detection in IoT systems through a decentralized approach. The framework dynamically optimizes hyperparameters using the Joint Strategy Optimization (JSO) algorithm, ensuring efficient model adaptation across heterogeneous IoT networks. A Long Short-Term Memory (LSTM)-based architecture accurately captures complex intrusion patterns. Federated learning is leveraged to enable collaborative model training across multiple IoT networks while maintaining data privacy and reducing vulnerability to data poisoning. The proposed model's robustness and adaptability were validated using Transformer, bi-LSTM, and GRU architectures. This framework demonstrates the potential to address evolving cyber threats and provide robust security solutions for IoT ecosystems.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11321"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the capability description of testing institution in Chinese phrase using a joint approach of semi-supervised K-Means clustering and BERT.","authors":"Gaoqing Xu, Qun Chen, Shuhang Jiang, Xiaohang Fu, Yiwei Wang, Qingchun Jiao","doi":"10.1038/s41598-025-92296-y","DOIUrl":"https://doi.org/10.1038/s41598-025-92296-y","url":null,"abstract":"<p><p>The capability parameters of third-party testing institutions not only serve as a critical reflection of their technical and quality management capabilities but also form the key basis for categorizing their testing abilities. However, current Chinese phrase-based descriptions of these capability parameters are influenced by diverse expression styles and varying internal standards, making it difficult to establish consistent criteria for classifying testing capabilities. This inconsistency presents notable difficulties for clients and regulatory bodies. Therefore, leveraging clustering techniques to uncover the intrinsic relationships and latent information between testing capabilities and their corresponding parameters is one of the crucial approaches to achieving scientific and reasonable classification of testing capabilities. Traditional text feature extraction methods suffer from several limitations, including sparse features, high-dimensional features, and lack of semantic information. These shortcomings complicate the classification and analysis of testing capability descriptions. To address this issue, this study focuses on the \"products and testing objects\" within the capability parameters of Chinese testing institutions as the research subject and proposes a joint model based on BERT and semi-supervised K-Means clustering. This model employs BERT to extract textual features from Chinese descriptive phrases and combines them with a small number of labeled samples for semi-supervised K-Means clustering analysis. The clustering results are then used to train a multi-output Softmax classifier, thereby enabling the classification of testing capabilities for third-party institutions. Experimental results demonstrate that the proposed method outperforms traditional methods such as TF-IDF and one-hot encoding when applied to the Chinese description datasets of testing institutions. Specifically, it exhibits advantages in reducing the dimensionality of textual features and enhancing clustering performance. When the proportion of labeled samples accounts for 10% of the total sample size, the method achieves optimal clustering results, with an average classifier accuracy of 89.8%.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11331"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients.","authors":"Agata Gabryelska, Szymon Turkiewicz, Adrian Gajewski, Julia Jaromirska, Dominik Strzelecki, Piotr Białasiewicz, Maciej Chałubiński, Marcin Sochal","doi":"10.1038/s41598-025-88834-3","DOIUrl":"https://doi.org/10.1038/s41598-025-88834-3","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is associated with circadian rhythm dysregulation plausibly through affecting clock genes. The study's purpose was to investigate the effect of one-night continuous positive airway pressure treatment (CPAP treatment) on circadian clock genes: BMAL1, CLOCK, CRY1, and PER1 at mRNA and protein levels. The study included 30 OSA patients, who underwent diagnostic polysomnography (PSG) and next a one-night effective CPAP treatment with PSG monitoring (CPAP). The blood was collected in the evening before and the morning after PSG and CPAP. Protein levels and mRNA expression were measured using ELISA and qRT-PCR, respectively. The increase in PER1 expression was observed in the morning after compared to the evening before CPAP (p = 0.005); additionally, PER1 protein level decreased in the morning after CPAP compared to the morning after PSG (p = 0.035). In CLOCK protein levels significant changes were observed: an increase in the morning after CPAP compared to the morning after PSG (p = 0.049), an increase in the morning after CPAP compared to the evening before (p = 0.006), and an increase in difference between the morning after and evening before CPAP vs. difference between morning after and evening before PSG (p = 0.012). Obtained results suggest that even short-term effective CPAP treatment might reverse circadian clock signaling pathway disruption in OSA.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11273"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between root canals and gingival sulci microbiota in secondary and persistent endodontic infections.","authors":"Dong Hyun Park, Euon Jung Tak, Ok-Jin Park, Hiran Perinpanayagam, Yeon-Jee Yoo, Hyo-Jung Lee, Yun-Seok Jeong, Jae-Yun Lee, Hyun Sik Kim, Jin-Woo Bae, Kee-Yeon Kum, Seung Hyun Han","doi":"10.1038/s41598-025-95522-9","DOIUrl":"https://doi.org/10.1038/s41598-025-95522-9","url":null,"abstract":"<p><p>Secondary/persistent endodontic infections (SPEIs) result from failed root canal therapy, causing persistent apical periodontitis. Current diagnostic methods for SPEIs predominantly rely on clinical and radiographic indicators, which often lack adequate sensitivity and specificity. Consequently, there is an urgent need to effectively detect SPEIs or monitor their progression. The aim of this study was to compare and characterize the microbiota of root canals and gingival sulci of teeth affected by SPEI to identify keystone pathogens as potential diagnostic biomarkers through advanced next-generation sequencing (NGS) techniques. Ninety samples from 30 affected teeth in 25 patients undergoing nonsurgical retreatment were analyzed. Bacterial DNA was extracted, the V3-V4 region of the 16S rRNA gene was amplified, and sequencing was performed (Illumina MiSeq). Amplicon sequence variants (ASVs) identified 16 phyla, 182 genera, and 390 species. Microbiota in root canals differed from gingival sulci, with Acinetobacter and Veillonella prevalent in canals, and Streptococcus and Actinomyces dominant in sulci. Certain species, including Shuttleworthella satelles, Olsenella uli, Dialister invisus, Massilia timonae, and Klebsiella pneumoniae were detected in both sites, suggesting microbial migration via anatomical structures. Detecting these potential keystone pathogens of SPEI as biomarkers in readily accessible sulcus fluid could facilitate diagnoses and monitoring of progression and/or resolution. These insights provide a foundation for more accurate and targeted diagnostic and therapeutic strategies for management of SPEIs.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11253"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of PIV value with early mortality in ICU patients with sepsis-associated acute kidney injury from the MIMIC IV database.","authors":"Heping Xu, Xinyi Cai, Huan Niu, Xiongwei Cai, Ping He, Yanhong Ouyang","doi":"10.1038/s41598-025-96320-z","DOIUrl":"https://doi.org/10.1038/s41598-025-96320-z","url":null,"abstract":"<p><p>Sepsis is a severe systemic inflammatory response, and sepsis-associated acute kidney injury (SA-AKI) is one of its most common complications. The pan-immune inflammation value (PIV), a novel inflammatory index, is designed to comprehensively reflect the status of systemic immune and inflammatory responses. However, the relationship between PIV and short-term clinical outcomes in SA-AKI patients remains unclear. This study was a retrospective analysis of SA-AKI patients from the MIMIC-IV database. The Boruta algorithm was used to identify key features predicting short-term mortality in SA-AKI patients. The relationships between ln (PIV) and all-cause mortality at 28 days and 90 days were assessed via multivariate Cox proportional hazards regression, subgroup analysis, sensitivity analysis, restricted cubic spline (RCS) modelling, and Kaplan‒Meier (K-M) survival analysis. A total of 4369 patients were included in the study, of whom 57.0% were male. Boruta analysis indicated that ln (PIV) was an important clinical feature. The results of multivariable Cox regression analysis revealed a positive correlation between ln (PIV) and mortality risk at both 28 days and 90 days (HR [95% CI] = 1.057 [1.009, 1.106], P = 0.019; HR [95% CI] = 1.075 [1.032, 1.120], P < 0.001). The RCS model revealed a nonlinear relationship between ln (PIV) and mortality at 28 and 90 days, with a critical threshold of 6.72. Above this threshold, a higher ln (PIV) was associated with increased mortality risk at both time points; sensitivity analyses confirmed that this association remained significant after specific patients were excluded. Subgroup analyses revealed that ln (PIV) significantly affected short-term mortality in diabetic patients (P < 0.05). Ln (PIV) is closely associated with short-term mortality in ICU patients with SA-AKI, suggesting its potential application in early risk assessment and clinical intervention.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11212"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deflectable video camera system for laparoscopic surgery based on shape memory alloy actuators.","authors":"Malte Pietsch, Konrad Henkel, René Körbitz, Ronny Hüttner, Kai Uhlig, Sascha Bruk, Matthieu Fischer, Jochen Hampe, Andreas Richter, Franz Brinkmann","doi":"10.1038/s41598-025-95898-8","DOIUrl":"https://doi.org/10.1038/s41598-025-95898-8","url":null,"abstract":"<p><p>Laparoscopic instruments are usually not deflectable and therefore have significant usability limitations in minimally invasive surgery. Flexible-tip devices have been introduced, but they are still controlled by manual Bowden cables or conventional motors and are heavy and expensive. An interesting alternative are shape memory alloy (SMA) actuators, because they are lightweight, cost-efficient and offer the potential for a universal actuator platform for laparoscopic and other endoscopic instruments. This paper presents a laparoscopic video camera with electronic deflection control via thumb joystick. Its actuator unit consists of four SMA wires, whose special tensioning mechanism ensures both optimal preload and length compensation. The camera is tiltable in two degrees of freedom, enabled by a laser-cut Nitinol joint. Based on three assembled units and an automated measurement system, the functionality of the camera system was characterised. Deflection angles of more than 178° per degree of freedom were achieved. At operating frequencies of up to 0.5 Hz, the units showed suitable deflection behaviour. Each remained operational for more than 1200 actuation cycles or 4.4 h of continuous operation. Furthermore, the influence of continuous temperature stimulation on characteristic device parameters was investigated. This work contributes to demonstrating the feasibility of SMA actuators for the electrical control of flexible-tip laparoscopic instruments. Temperature control in particular is a challenge for future work.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11354"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas.","authors":"Yandie Lin, Zhirui Li, Kai Zhang, Xiaoyue Li, Liwei Shao, Aijun Liu","doi":"10.1038/s41598-025-95643-1","DOIUrl":"https://doi.org/10.1038/s41598-025-95643-1","url":null,"abstract":"<p><p>The incidence of HPV-related oral squamous cell carcinomas (OSCC)and oropharyngeal squamous cell carcinomas (OPSCC) has increased significantly in recent years, but the role of HPV and P16 in OSCC and OPSCC remains controversial. Here, we evaluate the prevalence and prognostic significance of HPV-DNA, HPV E6E7 and P16 protein expression in OSCC and OPSCC patients. Additionally, we explore the correlation between P16 protein expression and HPV infection in these cases. The results show that the HPV DNA infection rate was significantly higher in OPSCC at 16.7% compared to 3.6% in OSCC (P = 0.002), HPV DNA positive cases were more prevalent in poorly- differentiated cases (P = 0.009). HPV E6E7 positive cases (10.4%) were only detected in OPSCC. P16 (+++) was observed in 6 of 48 OPSCC cases (12.5%) and in 1 of 140 OSCC cases (0.7%). P16 (+++) was significantly higher in OPSCC than in OSCC (P = 0.003). However, in OPSCC, Using P16 (+++) as a marker for HPV DNA infection yielded a sensitivity of 62.5%, Kappa coefficient between HPV DNA and P16 (+++) was 0.67 (P <0.0001). HPV DNA infection and P16 (+++) were not linked to prognosis (DFS: P = 0.35, P = 0.51; OS: P = 0.99, P = 0.96), Moreover, In OSCC, Age, T, N, and clinical stages were correlated with prognosis. Our results indicate that P16 (+++) can act as a biomarker for HPV- related high-risk tumors in OPSCC, yet not in OSCC. Besides, Older patients, less favorable T, N, and clinical stages having a worse prognosis in OSCC. In those with OPSCC, only the younger age of patients was associated with a better prognosis.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11270"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}