Scientific Reports最新文献

{"title":"Preventing muscle loss through early mobilization in non-critically ill older adults admitted to surgical intensive care units.","authors":"Onuma Chaiwat, Thanadol Wachiramatee, Benjaporn Sathitkarnmanee, Suchera Rattanamung, Piyapat Dajpratham, Napat Thikom, Chayanan Thanakiattiwibun","doi":"10.1038/s41598-025-12699-9","DOIUrl":"https://doi.org/10.1038/s41598-025-12699-9","url":null,"abstract":"<p><p>Intensive care unit-acquired weakness impairs recovery among older adults. We evaluated whether an early mobilization protocol reduces loss of muscle strength and mass compared with usual care in postoperative surgical intensive care unit (SICU) patients. In a before-and-after cohort at Siriraj Hospital, Thailand, 90 patients aged ≥ 65 years received usual care (June 2018-October 2019) and 90 subsequent patients followed a protocol-driven early-mobilization program (October 2019-November 2021). Daily assessments included muscle strength, Medical Research Council sum score (MRC-SS) and handgrip dynamometry, muscle mass (bioelectrical impedance vector analysis), and SICU optimal mobilization score (SOMS). Functional status 1 week post-discharge was measured by telephone using the Barthel Index for activities of daily living (ADL). Groups were comparable in age, sex, Acute Physiology and Chronic Health Evaluation II, and sequential organ failure assessment scores. The median change in the MRC-SS was + 1 point in both groups (P = 0.149), and the median muscle-mass change was + 0.2 kg versus + 0.5 kg (P = 0.713). The intervention arm achieved a higher median SOMS (2.0 vs. 1.0; P < 0.001) and fewer nosocomial infections (11.1% vs. 35.6%; P < 0.001). Barthel ADL scores improved in proportion to rehabilitation intensity, and no serious mobilization-related adverse events occurred. Early mobilization did not significantly alter muscle strength or mass but safely increased mobilization intensity, reduced infections, and improved short-term functional outcomes in older SICU patients.Trial registration: Thai Clinical Trials Registry. Trial no. TCTR20210203006. Retrospectively registered on January 31, 2021.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27198"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel anthocyanins hydroxyethyl cellulose film for intelligent chicken meat packaging with mechanical study, DFT calculations and molecular docking study.","authors":"Hebat-Allah S Tohamy","doi":"10.1038/s41598-025-10294-6","DOIUrl":"https://doi.org/10.1038/s41598-025-10294-6","url":null,"abstract":"<p><p>This study presents a new type of intelligent food packaging material. The film is created using hydroxyethyl cellulose (HEC) and carbon dots that have been modified with sulfur and nitrogen (S,N-CQDs). These S,N-CQDs are produced from discarded onion peels waste, making the packaging eco-friendly and versatile for food preservation with naked eye response.. The S,N-CQDs within the HEC film (HEC-S,N-CQDs) exhibit remarkable fluorescent change when contact with Salmonella. When applied to chicken meat, the film effectively monitors spoilage by changing color from red to light red. This color change is attributed to the film's pH sensitivity and its interaction with the increasing pH associated with meat deterioration. The color change which visualized by the naked-eye was an indication of the chicken meat spoilage. These make the film capable of visually detecting changes in food quality, such as spoilage, and inhibiting the growth of foodborne pathogens like Salmonella. Additionally, the antimicrobial properties of S,N-CQDs contribute to extending the shelf life of the packaged meat by 12 days which is more longer than the film without S,N-CQDs (3 days). DFT calculations and decreased the energy gap (0.02664 eV) prove the strong chemical reaction between HEC and S,N-CQDs within the film. The low bond length between the ligand and Salmonella (2.43 A°) compared to the HEC film without S,N-CQDs (2.54 A°) prove the high efficiency of antimicrobial activity for the film which containing S,N-CQDs.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27311"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse event reports of seizure for insomnia medication from 1967 to 2023.","authors":"Tae Hyeon Kim, Kyeongmin Lee, Jiyoung Hwang, Suhyun Lee, Hyesu Jo, Hanseul Cho, Hayeon Lee, Hye Jeong Baek, Jiseung Kang, Christa J Nehs, Guillaume Fond, Laurent Boyer, Eun Kyoung Chung, Dong Keon Yon","doi":"10.1038/s41598-025-11314-1","DOIUrl":"https://doi.org/10.1038/s41598-025-11314-1","url":null,"abstract":"<p><p>Insomnia may negatively impact seizure control; however, the corresponding evidence remains limited. This study analyzed the seizure risk associated with various insomnia medications using a comprehensive pharmacovigilance database and identified safe options for patients at high risk of seizures. VigiBase, a database of adverse drug reaction reports from over 140 countries, comprises 35 million reports published from 1967 to 2023. Medications for insomnia include benzodiazepines, Z-drugs, antidepressants, atypical antipsychotics, first-generation H1 antagonists, orexin receptor agonists, melatonin, and melatonin receptor agonists. We assessed the association between insomnia medications and seizure risk by analyzing the reported odds ratio (ROR) with 95% confidence intervals (CI) and the information component (IC) with IC₀₂₅. In total, 17,967 cases of seizures associated with insomnia medications were reported, revealing a significant association (ROR, 2.12 [95% CI, 2.09 to 2.15]; IC, 1.05 [IC₀₂₅, 1.03]). Based on the mechanism of action, seizures were significantly associated with benzodiazepines (ROR, 2.56 [95% CI, 2.49 to 2.64]; IC, 1.34 [IC₀₂₅, 1.29]), Z-drugs (ROR, 1.58 [1.49 to 1.69]; IC, 0.66 [0.56]), antidepressants (ROR, 2.52 [2.43 to 2.61]; IC, 1.32 [1.26]), atypical antipsychotics (ROR, 1.92 [1.88 to 1.97]; IC, 0.93 [0.89]), first-generation H1 antagonists (ROR, 2.08 [1.98 to 2.19]; IC, 1.05 [0.96]), and melatonin (ROR, 1.81 [1.49 to 2.20]; IC, 0.84 [0.51]). In contrast, orexin receptor antagonists (ROR, 0.81 [95% CI, 0.61 to 1.07]; IC, - 0.30 [IC₀₂₅, - 0.77]) and melatonin receptor agonists (ROR, 1.20 [0.80 to 1.81]; IC, 0.26 [- 0.44]) showed no significant association with seizures. Although the disproportionality analysis did not allow causal interpretation, our study highlights significant variations in seizure signal among insomnia medications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27308"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of psychological support in patients with unilateral peripheral hypofunction.","authors":"Laura Lijić, Tihana Mendeš, Andrijana Včeva, Željko Zubčić, Hrvoje Mihalj, Matej Rezo, Kristina Kralik, Hrvoje Vidić, Tamara Kopf, Antoneta Gudelj, Andrea Russo, Joško Šoda, Zlatko Kljajić","doi":"10.1038/s41598-025-12930-7","DOIUrl":"https://doi.org/10.1038/s41598-025-12930-7","url":null,"abstract":"<p><p>Nowadays, vestibular diseases are quite common in the population and significantly impair quality of life. Additionally, a notable problem is that a certain number of patients experience psychological consequences. Therefore, it is important to investigate the connection between vestibular damage and the potential need for psychological intervention. This study aims to examine the correlation between anxiety in individuals with unilateral peripheral vestibular disorder in relation to gender, age, and the existence of acute and chronic, compensated and uncompensated, partial and complete unilateral peripheral vestibular disorder. Additionally, it was important to determine the degree of free-floating anxiety, phobia-related anxiety, obsessiveness, somatic manifestations, depression, and hysteria in these patients using the Crown-Crisp Experience Index questionnaire. The study included 54 patients, 39 (72%) female and 15 (28%) male, with an average age of 61.5 ± 13.5 years. Results showed that the majority of participants had pronounced somatic anxiety (29.6%), followed by depression (14.8%), free-floating anxiety (9.4%), phobia-related anxiety (7.4%) and hysteria (7.4%) equally represented, and obsessiveness (1.8%) being the least pronounced. Nearly all participants (94%) were diagnosed with chronic hypofunction due to presenting for examination and diagnostic processing after the acute phase of the disease had ended. To conclude, no significant differences were observed in the common symptoms or personality traits within conventional categories of psychoneurotic and neurotic symptomatology concerning gender or the presence of vestibular hypofunction.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27231"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative and pharmacological investigation of bEVs from eight Lactobacillales strains.","authors":"Seoah Park, Jongsoo Mok, Hye-Min Yu, Hye-Jin An, Ga-Hyun Choi, Yeon-Seon Lee, Ki-Jin Kwon, Sung-Jun Choi, Kyung-Hee Kim, Soo-Jin Kim, Joonghoon Park","doi":"10.1038/s41598-025-12873-z","DOIUrl":"https://doi.org/10.1038/s41598-025-12873-z","url":null,"abstract":"<p><p>Bacterial extracellular vesicles (bEVs) have therapeutic potential by mimicking the effects of the microbiome. Here, we characterized bEVs from eight gram-positive Lactobacillales strains, evaluating their therapeutic potential. In primary characterization, Lactobacillus paracasei produced the largest bEVs (82.5 nm), while Lactococcus lactis yielded the highest number (3.2 × 10⁹ particles/mL). Lactobacillus plantarum had the highest protein content (0.124 pg/particle), while Lactobacillus salivarius had the greatest lipid content (16.3 µg/particle). Lipid content significantly influenced cytotoxicity in HEK293T cells (r² = 0.366, p = 0.037). Connectivity Map (CMap) analysis revealed correlations between bEVs from Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus acidophilus, and Streptococcus thermophilus and approved drugs for skin health. Experimentally, these bEVs enhanced collagen synthesis in fibroblasts by up to 1.25-fold (p < 0.001). Proteomic analysis identified distinct protein sets for each bEV. Further analysis demonstrated interaction networks between bEV proteins and human proteins that promote collagen production through the JAK-STAT, PI3K-AKT, and focal adhesion pathways. In conclusion, this study highlights the strain-specific characteristics and therapeutic potential of bEVs in promoting collagen production, presenting a novel approach to discovering new indications for bEVs in potential skin care applications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27263"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decadal (2012-2023) account of spatio-temporal variability in satellite-detected biomass fires on Indian landmass and their fire radiative power.","authors":"Deepanjan Majumdar","doi":"10.1038/s41598-025-11200-w","DOIUrl":"https://doi.org/10.1038/s41598-025-11200-w","url":null,"abstract":"<p><p>Worldwide escalation in wildfire incidences calls for continuous monitoring and early detection of fires to strengthen regional fire combating strategies. Inter-annual variability in fire count and Fire Radiative Power (FRP), spatial spread of fires in the most active seasons during 2012‒2023 on Indian landmass are reported. Fire data is extracted from 375 m active fire detection product of Visible Infrared Imaging Radiometer Suite (VIIRS) hosted by Suomi National Polar-orbiting Partnership. In every fire-year (March-February), constructed from the month of remarkable escalation in fires, fires were most populated in March or April in summer and November in winter. The yearly sum of fire spots ranged from 492,282 (2013) to 731,154 (2021). Inter-annual fire count trend grew at a rate of 10,794 per year, excluding COVID years of 2020 and 2021. Many cities with > 0.1 million population are located within or adjacent to the fire hot spots (20 km × 20 km grids), implying possibility of some impacts of seasonal fires both within and outside Wildfire Urban Interphases (WUIs). The study highlights the urgency of streamlining interventions to minimize wildfire incidences in order to protect forests, habitats, biodiversity, ecosystem services, human lives and property and minimize carbon loss, air pollution, perturbations in regional meteorology and radiative forcing.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27233"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GAAOA-Lévy: a hybrid metaheuristic for optimized multilevel thresholding in image segmentation.","authors":"Eman Mahmoud, Salem Alkhalaf, Tomonobu Senjyu, Masahiro Furukakoi, Ashraf Hemeida, Ghada Abozaid","doi":"10.1038/s41598-025-12142-z","DOIUrl":"https://doi.org/10.1038/s41598-025-12142-z","url":null,"abstract":"<p><p>Image segmentation is a critical task in image processing with applications in various domains, including industry and medicine. However, multilevel thresholding, a widely used segmentation technique, suffers from high computational complexity due to the exhaustive search for optimal thresholds. This paper addresses this challenge by proposing a hybrid Genetic Algorithm-Archimedes Optimization Algorithm (GAAOA), further enhanced with a Lévy flight function (GAAOA-Lévy), to improve efficiency and accuracy in multilevel thresholding. The integration of GA's crossover mechanism strengthens local search capabilities, leading to optimal segmentation with fewer iterations. The proposed algorithm is evaluated using standard benchmark images and compared against well-known optimization techniques. Experimental results demonstrate that GAAOA-Lévy outperforms existing methods in terms of Peak Signal-to-Noise Ratio (PSNR), computational efficiency, and convergence speed, particularly excelling in three-level thresholding while reducing computational costs for higher thresholds.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27232"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Order fulfillment planning with crowdsourcing integration.","authors":"Xuejing Cao, Zhongmin Da, Xuefei Wang","doi":"10.1038/s41598-025-11061-3","DOIUrl":"https://doi.org/10.1038/s41598-025-11061-3","url":null,"abstract":"<p><p>E-commerce has experienced rapid growth over the past decade, creating new challenges for last-mile and same-day delivery services. In response to the explosive increase in online orders and the emerging role of crowdsourcing in urban logistics, we introduce and formally define the Two-Echelon Multi-Depot Crowdsourcing Split Delivery Order Fulfillment Problem (2E-MDCSDOFP). This problem extends traditional two-echelon vehicle routing by integrating a crowdsourced delivery mechanism in the second echelon, allowing independent agents to perform customer deliveries. Furthermore, we relax the conventional constraint that each customer is served only once, enabling split deliveries to better utilize flexible and heterogeneous crowdsourced resources. We formulate the problem as a pure integer program aimed at minimizing the total logistics cost. To tackle the computational complexity, we develop an adaptive large neighborhood search algorithm tailored to exploit the problem structure and handle large-scale instances efficiently. Experimental results on extensive benchmark scenarios demonstrate that our approach significantly improves delivery flexibility and cost-effectiveness compared to traditional methods, highlighting the value of crowdsourcing in modern distribution systems.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27271"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic activities of two contact binaries in quadruple stellar systems.","authors":"Yuangui Yang, Shuang Wang","doi":"10.1038/s41598-025-10772-x","DOIUrl":"https://doi.org/10.1038/s41598-025-10772-x","url":null,"abstract":"<p><p>Based on observations from the Transiting Exoplanet Survey Satellite (TESS), we conducted a comprehensive study of two contact binaries, V752 Cen and HT Vir, in 2+2-type hierarchical quadruple stellar systems. TESS continuous light curves (LCs) reveal that [Formula: see text] exhibits random-walk-like or quasi-periodic variations, whereas [Formula: see text], shows small jumps. Using the Wilson-Devinney program, we obtained six sets of photometric solutions to trace the migration and evolution of a cool starspot on the stellar surface. Notably, such spot activity can significantly alter LCs and may even reverse minima depths, as observed around BJD[Formula: see text]2459282 for V752 Cen. From the TESS time-series LCs, we determined 529 eclipse timings (ETs). For HT Vir, the residuals of the primary and secondary minima show a strong anti-correlation, indicating the presence of starspots. Based on all available ETs, we constructed [Formula: see text] curves, which could be described by an upward parabola with the light-time effect (LiTE) induced by a third body. Given the third light of [Formula: see text] for HT Vir, we estimate the mass of the third body to be [Formula: see text]. For V752 Cen, the minimum mass of the third body is [Formula: see text], suggesting it may be a compact star. Finally, we updated the absolute parameters of the two studied binaries, whose components are normal or slightly evolved main-sequence stars.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27202"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung.","authors":"Katherine S Lee, Dylan T Boehm, Olivia A Miller-Stump, Nathaniel A Rader, Melissa Cooper, Holly A Cyphert, Emel Sen-Kilic, Mariette Barbier, F Heath Damron","doi":"10.1038/s41598-025-12320-z","DOIUrl":"https://doi.org/10.1038/s41598-025-12320-z","url":null,"abstract":"<p><p>Hypertension, diabetes, and obesity are comorbidities that influence severe cases of COVID-19 and are associated with weak humoral immunity after vaccination. We hypothesized that the diet-induced obese (DIO) K18-hACE2 mouse model could be utilized to reveal sex and DIO- specific differences in responses to COVID-19 immunization. To test this hypothesis, we immunized male and female DIO mice with a COVID-19 mRNA vaccine. Female DIO mice after immunization showed higher neutralizing antibody levels that recognized both SARS-CoV-2 variant RBD than male DIO mice. After Omicron SARS-CoV-2 challenge, single cell RNA sequencing analysis of lung tissue suggested decreased naïve B cell populations in immunized DIO mice in addition to an increase in macrophages in vaccinated female DIO mice. Analysis of viral burden revealed that the DIO variable did not impact immunity in immunized mice. Overall, this study underscores the ability of COVID-19 mRNA vaccines to confer protection in the comorbid SARS-CoV-2 murine challenge model.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27209"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}