Scientific Reports最新文献_第10页

House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway. 屋尘螨通过激活 PAR2 和 ERK 信号通路，刺激人支气管上皮细胞产生胸腺基质淋巴细胞生成素，并促进气道重塑。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79226-0

Yi-An Hsieh, Yi-Han Hsiao, Hsin-Kuo Ko, Yi-Luen Shen, Chien-Wen Huang, Diahn-Warng Perng, Kang-Cheng Su

{"title":"House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway.","authors":"Yi-An Hsieh, Yi-Han Hsiao, Hsin-Kuo Ko, Yi-Luen Shen, Chien-Wen Huang, Diahn-Warng Perng, Kang-Cheng Su","doi":"10.1038/s41598-024-79226-0","DOIUrl":"https://doi.org/10.1038/s41598-024-79226-0","url":null,"abstract":"House dust mites (HDM) are common aeroallergens linked to airway inflammation and remodeling in asthma. Protease-activated receptor 2 (PAR2) and thymic stromal lymphopoietin (TSLP) may mediate these immune responses. However, how the epithelium influences fibroblasts toward airway remodeling remains unclear. We hypothesize that HDM stimulates human bronchial epithelial cells (HBECs) to produce TSLP via PAR2 activation, driving fibroblasts toward remodeling processes. HBECs were treated with HDM, with or without the PAR2 antagonist FSLLRY-NH2 (FSL), and TSLP expression was measured by qPCR and ELISA. Phosphorylation of MAPKs was assessed by western blotting. Human lung fibroblasts (HLFs) were exposed to recombinant TSLP or conditioned medium (CM) from HDM-stimulated HBECs, with or without anti-TSLP antibodies. Fibroblast proliferation and collagen production were assessed as remodeling markers. HDM increased ERK phosphorylation (not p38 or JNK) and TSLP expression at mRNA and protein levels. FSL preincubation significantly reduced ERK phosphorylation and TSLP production: HDM-stimulated CM induced fibroblast proliferation and collagen production, effects suppressed by anti-TSLP or FSL. Direct treatment with recombinant TSLP also promoted fibroblast proliferation and collagen synthesis. These findings suggest that HDM promotes HBEC-to-HLF paracrine interactions via PAR2-ERK-TSLP axis, participating in airway remodeling. PAR2 antagonists may represent potential therapeutic targets for HDM-induced remodeling processes.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28649"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study of coupling response characteristics of offshore monopiles, seabed, and waves in various sea conditions. 各种海况下近海单桩、海床和波浪耦合响应特性的实验研究。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79858-2

Hailin Ye, Yaojiang Fan, Wenjing Bai, Chuwei Jiang

{"title":"Experimental study of coupling response characteristics of offshore monopiles, seabed, and waves in various sea conditions.","authors":"Hailin Ye, Yaojiang Fan, Wenjing Bai, Chuwei Jiang","doi":"10.1038/s41598-024-79858-2","DOIUrl":"10.1038/s41598-024-79858-2","url":null,"abstract":"As the global pursuit of renewable energy intensifies and the demand for offshore wind turbines rises, a comprehensive understanding of the coupling response characteristics of offshore monopiles, seabed, and waves in various sea conditions has become increasingly crucial. This paper reports on a wave flume experiment and seeks to contribute valuable insights by examining the coupling response of offshore monopiles, seabed, and waves exerting a relentless influence. The experimental results indicate that the impact of waves on monopiles is significant: there is greater pressure on the wave facing surface of the offshore piles than the other faces, and the pressure increases with increased wave height as well as the height of the monopile. The wave impact also gives rise to pile motion, squeezing the soil near the monopile and causing gradual pore water pressure around the monopile, and when the wave impact is strong enough, the monopile loses stability. Finally, the experimental results indicate significant differences in the coupling response characteristics of an offshore monopile, the seabed, and waves in various sea conditions. When the wave height was small, the pore water pressure attenuated quickly in the direction of the depth of the seabed; however, as the height and period of waves increased, when the test wave height was more than 18.6 cm and the period was more than 1.63 s, the dynamic pore water pressure around the monopile first decreased and then increased along the depth direction, which, generated by the wave impact, led to vibration and squeezing of the soil near the monopile leg. This indicates that the closer the pile bottom, the more intense the squeezing. By investigating this development across different sea conditions, this study provides a nuanced understanding that can inform the design of offshore monopiles in the face of various marine environmental challenges.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28560"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: The application of non-uniform magnetic field for thermal enhancement of the nanofluid flow inside the U-turn pipe at solar collectors. 退稿说明：应用非均匀磁场提高太阳能集热器 U 型转弯管道内纳米流体流动的热效率。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79444-6

Sida Li, Liudan Mao, As'ad Alizadeh, Xin Zhang, S Valiallah Mousavi

引用次数: 0

Manganese pollution in eastern India causing cancer risk. 印度东部的锰污染导致癌症风险。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-78478-0

Arun Kumar, Rajiv Kumar, Govind Kumar, Kanhaiya Kumar, Nirmal Kumar Chayal, Siddhant Aryal, Mukesh Kumar, Abhinav Srivastava, Mohammad Ali, Vivek Raj, Akhouri Bishwapriya, Muskan Manjari, Deepak Kumar, Santosh Kumar, Manisha Singh, Ashok Kumar Ghosh

{"title":"Manganese pollution in eastern India causing cancer risk.","authors":"Arun Kumar, Rajiv Kumar, Govind Kumar, Kanhaiya Kumar, Nirmal Kumar Chayal, Siddhant Aryal, Mukesh Kumar, Abhinav Srivastava, Mohammad Ali, Vivek Raj, Akhouri Bishwapriya, Muskan Manjari, Deepak Kumar, Santosh Kumar, Manisha Singh, Ashok Kumar Ghosh","doi":"10.1038/s41598-024-78478-0","DOIUrl":"https://doi.org/10.1038/s41598-024-78478-0","url":null,"abstract":"Groundwater poisoning by heavy metals has caused serious health hazards in the exposed population globally. Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blood samples of n = 1146 cancer patients were voluntarily obtained for the study, after their consent. Their household water samples were also collected for the study. All the samples were analysed for Mn contamination by Atomic Absorption Spectrophotometer. The study indicates high Mn contamination in the cancer patient blood samples with highest content as 6022 µg/L. Moreover, the cancer patient's household handpump water samples also contained elevated Mn contamination. The correlation coefficient study finds significant association between Mn contamination in blood of cancer patients and their handpump water. The carcinoma group of cancer patients mostly in Stage III & IV had significant Mn contamination in their blood (above WHO/BIS permissible limit). The geospatial study depicts Mn contamination in handpump water in the state of Bihar in correlation with cancer patient's blood samples. This novel finding is being reported in India for the first time, which correlates cancer with handpump drinking water. The long-term Mn exposure could be one of the causative agents for elevating cancer incidences. However, other confounding risk factors cannot be denied.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28588"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complex immune network and regional consistency in the human gastric mucosa revealed by high-resolution spectral cytometry. 高分辨率光谱细胞仪揭示人类胃黏膜复杂的免疫网络和区域一致性。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-78908-z

Ángel De Prado, Paloma Cal-Sabater, Aida Fiz-López, Sandra Izquierdo, Daniel Corrales, Francisco Pérez-Cózar, Juan H-Vázquez, Elisa Arribas-Rodríguez, Cándido Perez-Segurado, Álvaro Martín Muñoz, José A Garrote, Eduardo Arranz, Concepción Marañón, Sara Cuesta-Sancho, Luis Fernández-Salazar, David Bernardo

{"title":"Complex immune network and regional consistency in the human gastric mucosa revealed by high-resolution spectral cytometry.","authors":"Ángel De Prado, Paloma Cal-Sabater, Aida Fiz-López, Sandra Izquierdo, Daniel Corrales, Francisco Pérez-Cózar, Juan H-Vázquez, Elisa Arribas-Rodríguez, Cándido Perez-Segurado, Álvaro Martín Muñoz, José A Garrote, Eduardo Arranz, Concepción Marañón, Sara Cuesta-Sancho, Luis Fernández-Salazar, David Bernardo","doi":"10.1038/s41598-024-78908-z","DOIUrl":"https://doi.org/10.1038/s41598-024-78908-z","url":null,"abstract":"The immune cellular landscape from the gastric mucosa remains largely unknown despite its relevance in several inflammatory conditions. Human gastric biopsies were obtained from the antrum, body and incisura from 10 individuals to obtain lamina propria mononuclear cells that were further characterized by spectral cytometry. Phenotypic hierarchical analyses identified a total of 52 different immune cell subsets within the human gastric mucosa revealing that T-cells (> 60%) and NK cells (> 20%) were the main populations. Within T-cells, CD4+ and CD8+ were equally represented with both subsets displaying mainly a memory and effector phenotype. NK cells, on the contrary, were largely of the early phenotype. No regional differences were observed for any subsets among the 3 locations. Following unsupervised analysis, a total of 82 clusters were found. Again, no differences were observed amongst locations although a great degree of inter-individual variability was found, largely influenced by the presence of H. pylori infection and dyspepsia. We have unraveled the human gastric immune cellular subset composition and a unique interindividual immune fingerprint with no inter-regional variations.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28685"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XAI-driven CatBoost multi-layer perceptron neural network for analyzing breast cancer. XAI 驱动的 CatBoost 多层感知器神经网络用于分析乳腺癌。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79620-8

P Naga Srinivasu, G Jaya Lakshmi, Abhishek Gudipalli, Sujatha Canavoy Narahari, Jana Shafi, Marcin Woźniak, Muhammad Fazal Ijaz

{"title":"XAI-driven CatBoost multi-layer perceptron neural network for analyzing breast cancer.","authors":"P Naga Srinivasu, G Jaya Lakshmi, Abhishek Gudipalli, Sujatha Canavoy Narahari, Jana Shafi, Marcin Woźniak, Muhammad Fazal Ijaz","doi":"10.1038/s41598-024-79620-8","DOIUrl":"https://doi.org/10.1038/s41598-024-79620-8","url":null,"abstract":"Early diagnosis of breast cancer is exceptionally important in signifying the treatment results, of women's health. The present study outlines a novel approach for analyzing breast cancer data by using the CatBoost classification model with a multi-layer perceptron neural network (CatBoost+MLP). Explainable artificial intelligence techniques are used to cohere with the proposed CatBoost with the MLP model. The proposed model aims to enhance the interpretability of predictions in breast cancer diagnosis by leveraging the benefits of CatBoost classification technique in feature identification and also contributing towards the interpretability of the decision model. The proposed CatBoost+MLP has been evaluated using the Shapley additive explanations values to analyze the feature significance in decision-making. Initially, the feature engineering is done using the analysis of variance technique to identify the significant features. The MLP model alone and the CatBoost+MLP model are being analyzed using divergent performance metrics, and the results obtained are compared with contemporary breast cancer identification techniques.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28674"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Selective manipulation of the inositol metabolic pathway for induction of salt-tolerance in indica rice variety. 作者更正：选择性操纵肌醇代谢途径诱导籼稻品种的耐盐性

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79452-6

Rajeswari Mukherjee, Abhishek Mukherjee, Subhendu Bandyopadhyay, Sritama Mukherjee, Sonali Sengupta, Sudipta Ray, Arun Lahiri Majumder

引用次数: 0

China and the U.S. produce more impactful AI research when collaborating together. 中美合作进行的人工智能研究更具影响力。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79863-5

Bedoor AlShebli, Shahan Ali Memon, James A Evans, Talal Rahwan

{"title":"China and the U.S. produce more impactful AI research when collaborating together.","authors":"Bedoor AlShebli, Shahan Ali Memon, James A Evans, Talal Rahwan","doi":"10.1038/s41598-024-79863-5","DOIUrl":"https://doi.org/10.1038/s41598-024-79863-5","url":null,"abstract":"Artificial Intelligence (AI) has become a disruptive technology, promising to grant a significant economic and strategic advantage to nations that harness its power. China, with its recent push towards AI adoption, is challenging the U.S.'s position as the global leader in this field. Given AI's massive potential, as well as the fierce geopolitical tensions between China and the U.S., several recent policies have been put in place to discourage AI scientists from migrating to, or collaborating with, the other nation. Nevertheless, the extent of talent migration and cross-border collaboration are not fully understood. Here, we analyze a dataset of over 350,000 AI scientists and 5,000,000 AI papers. We find that since 2000, China and the U.S. have led the field in terms of impact, novelty, productivity, and workforce. Most AI scientists who move to China come from the U.S., and most who move to the U.S. come from China, highlighting a notable bidirectional talent migration. Moreover, the vast majority of those moving in either direction have Asian ancestry. Upon moving, those scientists continue to collaborate frequently with those in the origin country. Although the number of collaborations between the two countries has increased since the dawn of the millennium, such collaborations continue to be relatively rare. A matching experiment reveals that the two countries have always been more impactful when collaborating than when each works without the other. These findings suggest that instead of suppressing cross-border migration and collaboration between the two nations, the science could benefit from promoting such activities.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28576"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke. 围产期中风后，右侧脐周皮层的句子处理和情感拟声功能分区。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79302-5

Kelly C Martin, Anna Seydell-Greenwald, Peter E Turkeltaub, Catherine E Chambers, William D Gaillard, Elissa L Newport

{"title":"Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke.","authors":"Kelly C Martin, Anna Seydell-Greenwald, Peter E Turkeltaub, Catherine E Chambers, William D Gaillard, Elissa L Newport","doi":"10.1038/s41598-024-79302-5","DOIUrl":"https://doi.org/10.1038/s41598-024-79302-5","url":null,"abstract":"In healthy adults different language abilities-sentence processing versus emotional prosody-are supported by the left (LH) versus the right hemisphere (RH), respectively. However, after LH stroke in infancy, RH regions often support both abilities with normal outcomes. This finding raises an important question: How does the functional map of RH regions change to support both emotional prosody and also typically left-lateralized language functions after an early LH stroke? Does sentence processing simply become reflected into RH frontotemporal regions and overlap with emotional prosody processing? Or do these functions overlap less than would be expected with simple mirroring? In the current work we used task fMRI to examine precisely how sentence processing and emotional prosody processing are both organized in the intact RH of individuals who suffered a large LH perinatal arterial ischemic stroke (LHPS participants). We evaluated the activation of two fMRI tasks that probed auditory sentence processing and emotional prosody processing, comparing the overlap for these two functions in the RH of individuals with perinatal stroke with the symmetry of these functions in the LH and RH of their healthy siblings. We found less activation overlap in the RH of individuals with LH perinatal stroke than would be expected if both functions retained their typical spatial layout, suggesting that their spatial segregation may be an important feature of a functioning language system.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28602"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary game analysis of building a sustainable intelligent elderly care service platform. 构建可持续智能养老服务平台的进化博弈分析。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79976-x

Yiling Ma, Youshuai Sun, Qian Guo, Xiaoli Wang

{"title":"Evolutionary game analysis of building a sustainable intelligent elderly care service platform.","authors":"Yiling Ma, Youshuai Sun, Qian Guo, Xiaoli Wang","doi":"10.1038/s41598-024-79976-x","DOIUrl":"https://doi.org/10.1038/s41598-024-79976-x","url":null,"abstract":"With the rapid aging of populations and advancements in information technology, the development of intelligent elder-care service platforms (IESPs) has gained momentum. This paper examines the feasibility and strategies for constructing an IESP. Unlike commercial internet platforms, IESP facilitates transactions in elderly care services, which are quasi-public goods requiring government guidance and multi-stakeholder collaboration. Utilizing value co-creation theory, this study constructs a tripartite evolutionary game model involving a digital technology company, a social organization, and an elderly care service provider to analyze factors influencing stakeholder behavior. The findings reveal that sustained value co-creation is influenced by platform revenue, participation costs, reputation effects, and government subsidies. To optimize outcomes, the government should balance stakeholder interests, ensure reasonable profits for the digital company and social organization, and reduce participation costs through grassroots mobilization, data support, and subsidies for digital transformation. Strengthening reputation management and standardizing service evaluations are also crucial for achieving system equilibrium.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28653"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0