Scientific Reports最新文献_第9页

VLSI implementation of a modified min-max median filter using an area and power competent tritonic sorter for image denoising. 使用面积和功耗适中的三元分选器对改进的最小-最大中值滤波器进行 VLSI 实现，用于图像去噪。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-80053-6

Chrishia Christudhas, Annis Fathima

{"title":"VLSI implementation of a modified min-max median filter using an area and power competent tritonic sorter for image denoising.","authors":"Chrishia Christudhas, Annis Fathima","doi":"10.1038/s41598-024-80053-6","DOIUrl":"https://doi.org/10.1038/s41598-024-80053-6","url":null,"abstract":"The prominence of image processing in today's cutting-edge technology is undeniable. Integrating software with hardware leverages both strengths, resulting in a real-time processing system that is efficient and streamlined. Raw images are usually affected by noise, which hinders the acquisition of good-quality and detailed images; hence, denoising becomes necessary. This paper proposes a modified min-max median (MMM) filter to remove impulse noise and a Tritonic sorter to localize corrupted pixels. The proposed denoising method focuses on localizing noisy pixels, unlike traditional denoising approaches, which focus only on noise detection and filtering. A min-max sheet provides the location of the corrupted pixels, and filtering is performed on them. The Tritonic Sorter, consisting of a max locator and a min locator, compares three input values and finds the minimum, maximum and median values among them. Compared to other state-of-the-art methods, the proposed method minimizes the number of comparators needed to carry out the sorting process. The proposed method was synthesized in the ZedBoard Zynq kit using the Vivado tool. The results show that the area improved by 27%, and the power improved by 16.23% compared with those of the existing method.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28628"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study. 路德维希港风险与心血管健康研究》中血清矿物质浓度与肾功能死亡率之间的关系。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79575-w

Angela P Moissl, Graciela E Delgado, Marcus E Kleber, Bernhard K Krämer, Winfried März, Stefan Lorkowski

{"title":"Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study.","authors":"Angela P Moissl, Graciela E Delgado, Marcus E Kleber, Bernhard K Krämer, Winfried März, Stefan Lorkowski","doi":"10.1038/s41598-024-79575-w","DOIUrl":"https://doi.org/10.1038/s41598-024-79575-w","url":null,"abstract":"The association of serum concentrations of minerals and phosphate with overall and cardiovascular mortality based on renal function is poorly understood. 3307 patients (average age 62.7 ± 10.6 years) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study were grouped by estimated glomerular filtration rate (eGFR) into three categories: < 60, 60-89, and ≥ 90 mL/min per 1.73 m2, per KDIGO 2022 guidelines and were analysed using Cox regression. Low serum sodium and iron concentrations were associated with poor renal function and increased overall mortality risk, whereas higher serum zinc concentrations were associated with reduced overall and cardiovascular mortality risk. Elevated serum copper concentrations were associated with increased mortality risk across all eGFR categories. Comparing low and normal eGFR, we observed a fourfold increase in all-cause mortality risk for eGFR < 60 mL/min per 1.73 m2 and a twofold increase for eGFR 60-89 mL/min per 1.73 m2, accompanied by changes in serum mineral concentrations. The optimal range of mineral and phosphate concentrations in serum was strongly related to renal function. To reduce mortality risk, it's important to regularly monitor serum mineral and phosphate concentrations as well as renal function, especially in cardiovascular patients with compromised renal function.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28581"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYP4BN4v7 regulates the population density dependent oocyte maturity rate in bean beetles. CYP4BN4v7 可调节豆瓣菜中与种群密度相关的卵母细胞成熟率。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79866-2

Qianquan Chen, Yongqin Li, Zheng Fang, Qingshan Wu, Leitao Tan, Qingbei Weng

{"title":"CYP4BN4v7 regulates the population density dependent oocyte maturity rate in bean beetles.","authors":"Qianquan Chen, Yongqin Li, Zheng Fang, Qingshan Wu, Leitao Tan, Qingbei Weng","doi":"10.1038/s41598-024-79866-2","DOIUrl":"https://doi.org/10.1038/s41598-024-79866-2","url":null,"abstract":"The bean beetle (Callosobruchus maculatus) clearly exhibits population density-dependent polymorphism. Cytochrome P450 (CYP) is involved in many aspects of the physiological activities of insects. However, the role of CYP in population density-dependent polymorphisms remains unknown. The terminal oocyte maturity rate of high-population-density individuals (H) was faster than that of low-population-density individuals (L). A total of 56 CYP-like genes were identified from transcriptomic and genomic data, including seven clan 2 CYP-like genes, seven mitochondrial CYP-like genes, 19 clan 3 CYP-like genes, and 23 clan 4 CYP-like genes. Gene duplication might occur in CYP9Z4-like, CYP345A1-like, CYP345A2-like, CYP349A1-like, CYP349A2-like, and CYP4BN4-like. Thirteen and two CYP-like genes were up-regulated and down-regulated, respectively, in H. Among these CYP-like genes, CYP4BN4v7-like was the most abundant CYP. CYP4BN4v7-like was more highly expressed in the head than in the thorax and abdomen. Its mRNA levels in the head, thorax, and abdomen were greater in H than in L. After RNA interference decreased its mRNA level, the terminal oocyte maturity rate decreased. Moreover, the expression level of insulin-like peptide 1 (ILP1), which plays a vital role in regulating terminal oocyte development, decreased in the head. In conclusion, CYP4BN4v7-like modulated the population density-dependent terminal oocyte maturity rate by regulating the expression of ILP1.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28574"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of mode strengths in channel waveguide from the complex electric field. 根据复电场确定通道波导中的模式强度

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-80054-5

Isaac Doughan, Atri Halder, Igor Reduto, Matias Koivurova, Timo Aalto, Matthieu Roussey, Jari Turunen

{"title":"Determination of mode strengths in channel waveguide from the complex electric field.","authors":"Isaac Doughan, Atri Halder, Igor Reduto, Matias Koivurova, Timo Aalto, Matthieu Roussey, Jari Turunen","doi":"10.1038/s41598-024-80054-5","DOIUrl":"https://doi.org/10.1038/s41598-024-80054-5","url":null,"abstract":"We show that the mode strengths of a guided field in an arbitrary asymmetric channel waveguide can be uniquely determined from self-referencing interferometric measurements at the exit plane of the waveguide. This requires knowledge of both the amplitude and phase of the complex electric field distribution. Although the amplitude can be obtained from the measured intensity profile easily, the phase retrieval is usually non-trivial. We develop an innovative, alternative and promising technique, where the complex cross-spectral density (CSD) function is measured using a customized wavefront folding interferometer. We then construct the total electric field (complex valued), from which we can determine the strengths of the allowed modes for an asymmetric strip waveguide. Our retrieval algorithm also provides the phase information (intermodal dispersion) associated with each mode, directly from the measured electric field distribution. Moreover, we experimentally demonstrate the developed scheme for different in-coupling (butt-coupling) conditions, resulting in different modal strength distributions.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28665"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of machine learning models for predicting depressive symptoms in knee osteoarthritis patients. 开发用于预测膝关节骨关节炎患者抑郁症状的机器学习模型。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79601-x

Dan Li, Han Lu, Junhui Wu, Hongbo Chen, Meidi Shen, Beibei Tong, Wen Zeng, Weixuan Wang, Shaomei Shang

{"title":"Development of machine learning models for predicting depressive symptoms in knee osteoarthritis patients.","authors":"Dan Li, Han Lu, Junhui Wu, Hongbo Chen, Meidi Shen, Beibei Tong, Wen Zeng, Weixuan Wang, Shaomei Shang","doi":"10.1038/s41598-024-79601-x","DOIUrl":"https://doi.org/10.1038/s41598-024-79601-x","url":null,"abstract":"Knee osteoarthritis (KOA) combined with depressive symptoms is prevalent and leads to poor outcomes and significant financial burdens. However, practical tools for identifying at-risk patients remain limited. A robust prediction model is needed to address this gap. This study aims to develop and validate a predictive model to identify KOA patients at risk of developing depressive symptoms. The China Health and Retirement Longitudinal Survey (CHARLS) data were used for model development and the Osteoarthritis Initiative (OAI) for external validation. 18 potential predictors were selected using LASSO regression. 4 machine learning models-logistic regression, decision tree, random forest, and artificial neural network-were developed. Model performance was assessed using the area under the operating characteristic curve (AUC), calibration curves, and decision curve analysis. The most important features were extracted from the optimal model on external validation. A total of 469 individuals were included, with 70% used for training and 30% for testing. The random forest model achieved the best performance, with an AUC of 0.928 in the test set, outperforming logistic regression (AUC 0.622), decision tree (AUC 0.611), and neural network models (AUC 0.868). External validation revealed an AUC of 0.877 (95% CI: 0.864-0.889) for the adjusted random forest model. Pain severity was the most significant predictor, followed by the five-time sit-to-stand test (FTSST) and sleep problems. This study is the first in China to apply a predictive model for depressive symptoms in KOA patients, offering a practical tool for early risk identification using routinely available data.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28603"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and X-ray microtomography of sandwich-structured PEEK implants for skull defect repair. 用于颅骨缺损修复的夹层结构 PEEK 植入物的制造和 X 射线显微层析。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-80103-z

Mei-Li Qi, Minghua Li, Kunshan Yuan, Enhui Song, Haijun Zhang, Shengkun Yao

{"title":"Fabrication and X-ray microtomography of sandwich-structured PEEK implants for skull defect repair.","authors":"Mei-Li Qi, Minghua Li, Kunshan Yuan, Enhui Song, Haijun Zhang, Shengkun Yao","doi":"10.1038/s41598-024-80103-z","DOIUrl":"https://doi.org/10.1038/s41598-024-80103-z","url":null,"abstract":"Bone defects pose a significant risk to human health. Medical polyetheretherketone (PEEK) is an excellent implant material for bone defect repair, but it faces the challenge of bone osteoconduction and osseointegration. Osteoconduction describes the process by which bone grows on the surface of the implant, while osseointegration is the stable anchoring of the implant achieved by direct contact between the bone and the implant. Bone defects repair depends on the implant's three-dimensional spatial structure, including pore size, porosity, and interconnections to a great extent. However, it is challenging to fabricate the porous structures to meet specific requirements and to characterize them without causing damage. In this study, we designed and fabricated sandwich-like PEEK implants mimicking the three-layer structures of the skull, whose defects imposes a significant burden on young adulthood and paediatric populations, and performed in-line phase-contrast synchrotron X-ray microtomography to non-destructively investigate the internal porous microstructures. The sandwich-like three-layer microstructure, comprising a dense layer, a loose layer and a dense layer in succession, exhibits structural similarity to that in a natural skull. This work demonstrated the fabrication of the sandwich-like PEEK implant that could potentially enhance osteoconduction and osseointegration. Furthermore, the interior structures and residual porogen sodium chloride particles were observed within the PEEK implant, which cannot be realized by other microscopic methods without destroying the sample. It highlights the advantages and potential of using synchrotron X-ray microtomography to analyze the structure of biomedical materials. This study provides theoretical guidance for the further design and fabrication of PEEK bone repair materials and will advance the clinical application of innovative bioactive bone repair materials.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28585"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the rock cutting performance and feasibility verification of small-scale rotary cutting test for disc cutter. 圆盘切割机岩石切割性能研究及小型旋转切割试验可行性验证。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-80059-0

Zilong Yang, Yong Hu, Mingxu Xu, Hao Pang, Youpeng Gu, Baicheng Zheng

{"title":"Research on the rock cutting performance and feasibility verification of small-scale rotary cutting test for disc cutter.","authors":"Zilong Yang, Yong Hu, Mingxu Xu, Hao Pang, Youpeng Gu, Baicheng Zheng","doi":"10.1038/s41598-024-80059-0","DOIUrl":"10.1038/s41598-024-80059-0","url":null,"abstract":"Small-scale rock cutting tests serve as a simple approach to evaluate the performance of tunnel boring machines (TBMs), but the feasibility of this method requires further investigation. Herein, a small-scale rotary cutting machine is developed to conduct rock cutting tests, and the cutting performance is investigated. The results indicate that similar cutting performance can be achieved through both small-scale and full-scale tests. The critical penetration depth for effective rock cutting by the cutter is 0.5 mm, below which the cutter grinds against the rock. The optimal ratio of cutting spacing to penetration depth obtained in small-scale tests is 4.47. A result within the empirical range can be achieved by multiplying the optimal small-scale cutting parameters with the scale coefficient, demonstrating the feasibility of using small-scale tests to guide the design of cutter heads. Based on the test result, the scale prediction model is constructed to predict the full-scale cutting force. The predictive capability of the proposed model and CSM model is validated using 72 sets of full-scale test data involving the same types of rock, and the predictions of the proposed model are closer to the test data.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28558"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing flexural strength of RC beams with recycled aggregates and CFRP using machine learning models. 利用机器学习模型优化使用再生骨料和 CFRP 的 RC 梁的抗弯强度。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-79287-1

Thanh-Hung Nguyen, Hoang-Thach Vuong, Jim Shiau, Trung Nguyen-Thoi, Dinh-Hung Nguyen, Tan Nguyen

{"title":"Optimizing flexural strength of RC beams with recycled aggregates and CFRP using machine learning models.","authors":"Thanh-Hung Nguyen, Hoang-Thach Vuong, Jim Shiau, Trung Nguyen-Thoi, Dinh-Hung Nguyen, Tan Nguyen","doi":"10.1038/s41598-024-79287-1","DOIUrl":"https://doi.org/10.1038/s41598-024-79287-1","url":null,"abstract":"This paper investigates the flexural bearing behavior of reinforced concrete beams through experimental analysis and advanced machine learning predictive models. The primary problem centers around understanding how varying compositions of construction materials, particularly the inclusion of recycled aggregates and carbon fiber-reinforced polymer (CFRP), affect the structural performance of concrete beams. Eight beams, including those with natural aggregates, recycled aggregates, fly ash, and CFRP, were tested. The study employs state-of-the-art machine learning frameworks, including Random Forest Regressor (RFR), XGBoost (XGB), and LightGBM (LGBM). The formation of these models involved data acquisition from experiments, preprocessing of key input features (such as rebars area, cement portion, recycled and natural aggregate masses, silica fume, fly ash, compressive strength, and CFRP presence), model selection, and hyperparameter tuning using Pareto optimization. The models were then evaluated using performance metrics like Mean Squared Error (MSE), Mean Absolute Error (MAE), and coefficient of determination (R2). Outputs focus on load-induced deflection and mid-span displacement. With a dataset of 4851 samples, the optimized models demonstrated excellent performance. The experimental results revealed substantial enhancements in both compressive strength and load-bearing capacity, notably observed in beams incorporating 70% recycled aggregate and 10% silica fume. These beams exhibited a remarkable increase in compressive strength of up to 53.03% and a 7% boost in load-bearing capacity compared to those without recycled aggregate. By integrating experimental analysis with advanced computational techniques, this study advances the understanding of eco-friendly construction materials and their performance, shedding light on the intricate interactions between sustainable construction materials and the flexural bearing behavior of beams.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28621"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacovigilance study of famciclovir in the Food and Drug administration adverse event reporting system database. 食品药品管理局不良事件报告系统数据库中的泛昔洛韦药物警戒研究。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-80236-1

Runan Fang, Yang Zhou, Lu Han, Wenjing Chen, Ning Guan, Jianhong Li

{"title":"Pharmacovigilance study of famciclovir in the Food and Drug administration adverse event reporting system database.","authors":"Runan Fang, Yang Zhou, Lu Han, Wenjing Chen, Ning Guan, Jianhong Li","doi":"10.1038/s41598-024-80236-1","DOIUrl":"https://doi.org/10.1038/s41598-024-80236-1","url":null,"abstract":"Famciclovir, mainly used to treat herpes zoster, is rapidly transforms into penciclovir when administered orally. Our study evaluated adverse events (AEs) associated with famciclovir by mining data from the publicly available Food and Drug Administration Adverse Event Reporting System (FAERS) database, providing a reference for clinical safety. Disproportionality analysis (including reported odds ratio and proportional reporting ratio) and Bayesian methods (including Bayesian Confidence Propagation Neural Network and Gamma-Poisson Shrinkage) were used to quantify the AE signals associated with famciclovir. A total of 17,652,186 case reports were obtained from the FAERS database, and 432 famiclovir-related AEs were identified. Nausea, headache, altered mental status, vomiting, and dizziness were found to be the most common Aes, corresponding to those reported in the Food and Drug Administration (FDA) drug labelling and clinical trials. Our study found some potential AEs of famciclovir that were not mentioned in the FDA drug labelling, such as toxic encephalopathy, encephalopathy, ataxia, dysarthria, dementia, cerebral infarction, tremor, purpura, skin ulcers, acute pancreatitis, rhabdomyolysis, muscle twitching, increased blood urea, lowered blood pressure, hepatitis, disease recurrence, drug interactions, and pancytopenia. Our study identified potential famciclovir AE signals, providing insights for physicians to reduce possible side effects and promote the safe implementation of the drug in clinical settings.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28637"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental T2* as a measure of placental function across field strength from 0.55T to 3T. 从 0.55T 到 3T 的场强范围内，胎盘 T2* 作为胎盘功能的测量指标。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-19 DOI: 10.1038/s41598-024-77406-6

Megan Hall, Jordina Aviles Verdera, Daniel Cromb, Sara Neves Silva, Mary Rutherford, Serena J Counsell, Joseph V Hajnal, Lisa Story, Jana Hutter

{"title":"Placental T2* as a measure of placental function across field strength from 0.55T to 3T.","authors":"Megan Hall, Jordina Aviles Verdera, Daniel Cromb, Sara Neves Silva, Mary Rutherford, Serena J Counsell, Joseph V Hajnal, Lisa Story, Jana Hutter","doi":"10.1038/s41598-024-77406-6","DOIUrl":"https://doi.org/10.1038/s41598-024-77406-6","url":null,"abstract":"Placental MRI is increasingly implemented in clinical obstetrics and research. Functional imaging, especially T2*, has been shown to vary across gestation and in pathology. Translation into the clinical arena has been slow because of time taken to mask the region of interest and owing to differences in T2* results depending on field strength. This paper contributes methodology to remove these barriers by utilising data from 0.55, 1.5 and 3T MRI to provide a fully automated segmentation tool; determining field strength dependency of placental assessment techniques; and deriving normal ranges for T2* by gestational age but independent of field strength. T2* datasets were acquired across field strengths. Automatic quantification including fully automatic masking was achieved and tested in 270 datasets across fields. Normal curves for quantitative placental mean T2*, volume and other derived measurements were obtained in 273 fetal MRI scans and z-scores calculated. The fully automatic segmentation achieved excellent quantification results (Dice scores of 0.807 at 3T, 0.796 at 1.5T and 0.815 at 0.55T.). Similar changes were seen between placental T2* and gestational age across all three field strengths (p < 0.05). Z-scores were generated. This study provides confidence in the translatability of T2* trends across field strengths in fetal imaging.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28594"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0