Scientific Reports最新文献

{"title":"Investigating air temperature changes in Bhubaneswar city over 123 years from 1901 to 2023.","authors":"Abhipsa Das, Sarat Chandra Sahu, Roshan Beuria, Dipak Kumar Sahu, Artatrana Mishra, Amrutanshu Panigrahi, Abhilash Pati, Prajna Priyadarshini","doi":"10.1038/s41598-025-12746-5","DOIUrl":"https://doi.org/10.1038/s41598-025-12746-5","url":null,"abstract":"<p><p>This study examines long-term air temperature trends in Bhubaneswar, a rapidly urbanizing coastal city in eastern India, using data from 1901 to 2023. By analyzing maximum, minimum, and mean temperatures, we assess both natural climate variability and anthropogenic influences, including urban expansion. Statistical techniques such as homogenization, persistence analysis, and low-pass filtering reveal a pronounced warming trend, particularly in minimum temperatures, as an indication of an intensifying urban heat island effect. A weak but positive correlation between minimum temperature and population growth supports the role of urbanization in shaping local climate. These findings contribute to understanding urban climate evolution in tropical coastal settings where natural and human factors interact. Our results underscore minimum temperatures compared to maximum temperatures, indicating a warming trend likely driven by anthropogenic activities. Regression analysis between population growth and minimum temperature affirms a weak but notable positive correlation, indicating the gradual intensification of Bhubaneswar's local microclimate due to urban development. This study contributes to understanding climate dynamics in tropical, coastal, and urban regions, where natural and human factors converge, shaping distinct local climate patterns. Nonetheless, the climatic trends are less pronounced than the interannual fluctuations in temperature measurements. The little climatic differences across several generations are unlikely to have influenced human activities compared to the substantial impacts of interannual temperature variability.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27389"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and prognostic factors of necrotizing fasciitis in resource-limited regions based on 119 cases.","authors":"Yingbin Chen, Yintao Huang, Jiabao Shou, Rui Song, Jinjuan Tan, Jiyuan Deng","doi":"10.1038/s41598-025-13278-8","DOIUrl":"https://doi.org/10.1038/s41598-025-13278-8","url":null,"abstract":"<p><p>Necrotizing fasciitis (NF) is a rare, life-threatening soft tissue infection with high amputation and mortality rates, often due to delayed diagnosis and treatment. This study analyzes the clinical characteristics and prognostic factors of NF to improve treatment strategies. A retrospective study was conducted on 119 NF patients treated at a tertiary hospital in Guangxi, China, from 2017 to 2023. Data on demographics, laboratory parameters, microbiology, treatments, and outcomes were collected and analyzed. Comparisons were made between survivors and non-survivors, and between patients with and without amputation. The predictive performance of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) was assessed using receiver operating characteristic (ROC) curve analysis. Among 119 patients, the mean age was 56.7 years with a male-to-female ratio of 5.3:1. The lower extremities were most commonly affected (58.8%), and diabetes was prevalent (62.3%). Gram-negative bacteria were predominant (62.7%), particularly Escherichia coli (21.6%) and Klebsiella pneumoniae (19.4%), while Gram-positive bacteria were led by Staphylococcus aureus (14.9%). The overall antibiotic resistance rate was 18.7%, with Gram-negatives bacteria highly susceptible to ertapenem, imipenem, and piperacillin-tazobactam, and Gram-positives bacteria to vancomycin and levofloxacin. Amputation and in-hospital mortality rates were 16.8% and 11.8%, respectively. Risk factors for amputation encompassed lower extremity involvement, cutaneous and muscle necrosis, diabetes, elevated LRINEC scores, low RBC counts, and decreased albumin (all p < 0.05). Mortality was associated with advanced age, hypotension, coronary heart disease, hypoalbuminemia, elevated serum creatinine, uric acid, and lactate (all p < 0.05). The LRINEC score showed moderate predictive power for amputation (AUC = 0.726, cutoff = 8) but limited utility for mortality prediction (AUC = 0.592). NF predominantly affects middle-aged and elderly males, with diabetes as a common underlying condition. Early surgical intervention and empirical use of carbapenems combined with vancomycin are recommended for infection control. Enhancing early treatment effectiveness and optimizing disease management are key to improving patient outcomes in resource-limited settings.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27458"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Hankel inequalities of symmetric starlike functions in crescent-shaped domains and their application in image processing.","authors":"Bushra Kanwal, Arooj Iman, Shamsa Kanwal, Amal K Alkhalifa","doi":"10.1038/s41598-025-12935-2","DOIUrl":"https://doi.org/10.1038/s41598-025-12935-2","url":null,"abstract":"<p><p>This study explores some geometric properties of the class of symmetric starlike functions associated with a Crescent-shaped domain denoted by [Formula: see text]. Initially, we establish key coefficient inequalities and investigate upper bounds for the 2nd and 3rd order Hankel determinants. All the obtained results are sharp. These bounds provide deeper insights into the structural behavior of this class and contribute to a broader understanding of Geometric Function Theory. In addition to the theoretical findings, the practical implications of the results obtained are demonstrated in the domain of image processing. We used our estimated sharp Hankel determinants to develop a novel algorithm for image enhancement. The performance of the algorithm is evaluated on different image datasets of varying dimensions, with key quality metrics such as PSNR, SSIM, PCC, and MAE. Our experimental results indicate a significant improvement over conventional image enhancement techniques, particularly in retaining structural integrity and reducing distortions. In addition, a comparative study highlights the effectiveness of the proposed algorithm compared to existing methods reported in the literature, demonstrating its potential to enhance image quality in practical applications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27402"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a rare known anatomic formation: Parinaud's canal.","authors":"Guldane Magat, Sultan Uzun","doi":"10.1038/s41598-025-03576-6","DOIUrl":"https://doi.org/10.1038/s41598-025-03576-6","url":null,"abstract":"<p><p>Parinaud's canal (PC) is a structure located on the processus frontalis ossis maxilla. During the growth period, the shape of the nasal septum and the presence of nasal septal deviation (NSD) may affect facial morphological parameters. The aim of this study is to investigate the presence of PC and the effect of the NSD on facial morphological parameters. Radiographic images of 200 patients were retrospectively reviewed. On the CBCT images PC, NSD and Palate-Orbita angle were evaluated. The significance level was set at p = 0.05. PC was found to be present at a high rate in the general population and its presence was not significantly different according to the angle of nasal deviation (p > 0.05). The angle of NSD was found to increase statistically when the left PC diameter was 1 mm or less (p < 0.05). The mean Hard Palate - Orbital Angle was 46.66 ± 8.43 degrees in individuals with the right PC while this angle was 36.50 ± 1.65 degrees in those without a canal. his study revealed that PC is common in the general population and has no significant relationship with NSD angle. While a decrease in the diameter of the left Parinaud's canal is observed as the NSD increases, the Hard Palate - Orbital Angle varies depending on the presence of the right PC. These findings indicate PC may play an important role in nasal and orbital anatomy.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27460"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the correlation between nocturnal awakenings and occupational burnout in internal medicine physicians via online survey.","authors":"Jia Wu, Hanyun Zhang, Litao Jia, Chunpeng Zhu, Yuqi Wang, Yiping Chen, Caihua Wang","doi":"10.1038/s41598-025-12884-w","DOIUrl":"https://doi.org/10.1038/s41598-025-12884-w","url":null,"abstract":"<p><p>This study aims to screen for occupational burnout among internal medicine physicians through an online survey, and to explore the relationship between burnout and anxiety, depression, stress, and sleep. The findings are expected to help improve the mental and physical health of physicians, thereby enhancing the medical quality in hospitals. Maslach burnout inventory-general survey (MBI-GS) was used to assess physicians' burnout status, Minnesota satisfaction questionnaire (MSQ) was used to evaluate the job satisfaction, Generalized anxiety disorder 7 (GAD-7), Patient health questionnaire-9 (PHQ-9), and Perceived stress scale (PSS) were used to assess the psychological status, and Pittsburgh sleep quality index (PSQI) was used to evaluate sleep conditions. Frequent nocturnal awakenings significantly increase the risk of occupational burnout, but the impact differs by gender. For men, nocturnal awakenings ≤ 2 times/week do not significantly increase the burnout risk, while ≥ 3 times/week significantly increase the risk. For women, 1 or more nighttime awakenings per week significantly increase burnout risk, with a stronger effect than in men. Nocturnal awakenings 1-2 times/week and ≥ 3 times/week are independent risk factors for burnout. However, individuals with positive results on the GAD/PHQ/PSS scales showed a significantly higher risk of moderate burnout, even with less frequent nocturnal awakenings (< 1 time/week). As the frequency of nocturnal awakenings increases, the risk of burnout also increases, and GAD/PHQ/PSS positivity further exacerbates the risk. Nocturnal awakening is an independent risk factor for occupational burnout, with an increased risk among individuals testing positive for GAD/PHQ/PSS.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27462"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and computational analysis of AKR1C4 gene rs17134592 polymorphism in breast cancer among the Bangladeshi population.","authors":"Md Akeruzzaman Shaon, Farzana Ansari, Zimam Mahmud, Sonia Tamanna, Abdullah Al Saba, Rushafi Sikder, Tabassum Howlader, Md Zakir Hossain Howlader","doi":"10.1038/s41598-025-13411-7","DOIUrl":"https://doi.org/10.1038/s41598-025-13411-7","url":null,"abstract":"<p><p>Breast cancer is characterized by the unchecked proliferation of breast cells. Variations in the metabolism of steroid hormones can influence the risk of this disease by modifying the concentration and the potency of these hormones. The enzyme AKR1C4, primarily found in the liver, is crucial for regulating these hormone levels in the bloodstream. This research examined the relationship between a polymorphic variant (rs17134592) of the AKR1C4 gene and the susceptibility to breast cancer among the Bangladeshi population. A case-control study was conducted with 310 breast cancer patients and 310 healthy individuals from Bangladesh. DNA was extracted using an organic process, followed by genotyping through the PCR-RFLP technique. To validate the accuracy of genotyping results, a subset of PCR products was randomly selected and confirmed using Sanger sequencing. Statistical assessments were conducted to analyze the association of polymorphism, while molecular dynamics simulation and diverse computational methods were employed to predict the structural and functional impacts of the SNP. The results indicate that rs17134592 in the AKR1C4 gene is linked with a heightened risk for breast cancer (p < 0.0001, OR = 3.39, 95% CI = 1.80 to 6.50 for the GG genotype in additive model 2). The recessive model (GG vs. CC + CG) also showed an enhanced risk of susceptibility to breast malignancy (p < 0.0001, OR = 3.25, 95% CI = 1.78 to 6.08). In the subgroup of post-menopausal women, the risk of developing breast cancer was significantly higher for carriers of the GG genotype, with relative risks of 4.02 and 3.92, in the additive model 2 and recessive model, respectively. However, no significant correlations were observed between these genotypes and tumor grade or size in breast cancer patients. Computational analysis suggested that the L311V mutation (rs17134592) could potentially reduce the stability of the protein. Additionally, molecular dynamics simulations indicated that the L311V mutation introduces notable conformational instability to the AKR1C4 enzyme, potentially impacting its biological functionality and catalytic efficiency. In conclusion, the genetic variant rs17134592 has been identified as significantly correlated with the prevalence of breast cancer in the Bangladeshi population. Computational studies suggest that the L311V mutation in the AKR1C4 gene, corresponding to rs17134592, results in marked conformational instability and changes in enzyme functionality.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27526"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic map of the carotid body stem cell niche with focus on the O₂-sensing chemoreceptor cell lineage.","authors":"Ana Santamaría-Santiago, Verónica Sobrino, Luis Luna-Ramírez, José López-Barneo, Ricardo Pardal","doi":"10.1038/s41598-025-12397-6","DOIUrl":"https://doi.org/10.1038/s41598-025-12397-6","url":null,"abstract":"<p><p>Adaptive homeostatic responses to oxygen (O₂) deficiency (hypoxia) are essential for survival. The prototypical acute O₂-sensing organ is the carotid body (CB), a neural crest-derived tissue with chemoreceptor glomus cells that express hypoxia-inhibited K⁺ channels. This, in turn, leads to neurotransmitter release and the activation of nerve fibers terminating in the brainstem, evoking hyperventilation. The adult CB contains a population of multipotent stem cells capable of proliferating and differentiating into new chemoreceptor cells, supporting its growth during acclimatization to chronic hypoxia. The responsiveness of glomus cells to hypoxia relies on the constitutive expression of HIF2α and a set of HIF2α-dependent genes, which define a mitochondria-to-membrane signaling pathway for acute O₂ sensing. The genetic profiles of the various cell types within the CB, and how they change in response to sustained hypoxia, remain unknown. Here, we present a complete transcriptomic map of the CB, with an emphasis on the characterization of genetic profiles of the acute O₂-sensing neuronal cell lineage (multipotent progenitors, neuroblasts, and mature glomus cells). Acclimatization to chronic hypoxia involves the rapid conversion of neuroblasts into mature O₂-sensitive chemoreceptor cells and enhancement of the glomus cell O₂-sensing and neurosecretory genetic profile.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27452"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SNP rs615552 and lncRNA CDKN2B-AS1 influence brain cancer pathogenesis through multi-omic mechanisms.","authors":"Zheng Ye, Jiaqi Yuan, Qianbei Yi, Peng Xu, Wenbin Liu","doi":"10.1038/s41598-025-10360-z","DOIUrl":"https://doi.org/10.1038/s41598-025-10360-z","url":null,"abstract":"<p><p>Brain cancer represents a complex disease influenced by a multitude of genetic and epigenetic factors. This study aims to elucidate the role of specific single nucleotide polymorphisms (SNPs) and long non-coding RNAs (lncRNAs) in the pathogenesis of brain cancer, employing a multi-omics approach. We conducted extensive eQTL, mQTL, haQTL, sQTL, and caQTL analyses to identify genetic variants and lncRNAs associated with brain cancer. Integration with GWAS-GWAS colocalization analysis provided insights into shared genetic mechanisms with other diseases. We further investigated copy number variation (CNV) and methylation status in relation to gene expression, and their prognostic implications in different brain cancer subtypes. SNP rs615552_AL359922.1 exhibited significant colocalization with key genes CDKN2A, CDKN2B, and CDKN2B-AS1, implicating its role in the regulation of gene expression. The long non-coding RNA CDKN2B-AS1 demonstrated both co-occurrence and co-expression with CDKN2A and CDKN2B, suggesting a coordinated regulatory mechanism among these genes. TERT emerged as a gene with shared susceptibility across brain cancer and other diseases, indicating a common genetic pathway. Methylation sites associated with mQTL, such as cg03935379 (TERT) and cg14069088 (CDKN2A), were identified as independent prognostic factors for lower-grade glioma (LGG), but not for glioblastoma multiforme (GBM). Bulk RNA-seq, spatial, and single-cell transcriptomic analyses revealed that CDKN2B-AS1 is predominantly expressed in malignant and dendritic cells (DCs), and is associated with DNA repair pathways in malignant cells and antigen presentation genes in DCs. This study offers a comprehensive perspective on the genetic and molecular factors influencing brain cancer. The results highlight the intricate nature of gene regulation in cancer and suggest the potential of CDKN2B-AS1 as a key regulator of immune responses and tumor suppressor genes. The SNP rs615552_AL359922.1 represents a significant pathogenic SNP for brain cancer. The identification of shared genetic mechanisms, particularly involving TERT, with other diseases points to new opportunities for developing therapeutic targets and diagnostic tools. Future research should focus on functional validation and the investigation of environmental interactions to fully leverage these findings for advancing brain cancer management.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27490"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal dynamics of benzylisoquinoline alkaloid gene expression and co-expression networks during Papaver Somniferum developmental stages.","authors":"Zishi Wang, Quanzheng Yun, Jinyuan Hu, Zhen Wei, Deri Feng, Ning Li, He Xu, Lihong Fu, Zhenlong Wang, Shujin Li, Fangru Liu, Yan Wang, Bin Cong, Baishi Wang","doi":"10.1038/s41598-025-11942-7","DOIUrl":"https://doi.org/10.1038/s41598-025-11942-7","url":null,"abstract":"<p><p>Benzylisoquinoline alkaloids (BIAs) are essential secondary metabolites produced by Papaver somniferum, widely recognized for their pharmaceutical importance. This study employs transcriptome sequencing and weighted gene co-expression network analysis (WGCNA) to investigate the spatiotemporal expression patterns and regulatory networks of BIA-related genes across developmental stages and organs. A total of 23 co-expression modules were identified, revealing stage- and organ-specific dynamics in BIA biosynthesis. Key genes such as TYDC, PPO, and GsSRK demonstrated distinct regulatory roles during flowering and fruit maturation. Functional enrichment analysis uncovered critical pathways and transcription factors involved in alkaloid production. These findings enhance our understanding of the molecular regulation of BIAs and provide valuable insights for improving alkaloid yield through metabolic engineering and molecular breeding strategies.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27406"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable concrete production through the integration of waste foundry sand, fly ash, silica fume and metakaolin.","authors":"Tariq Ali, Muhammad Zeeshan Qureshi, Inamullah Inam, Nabil Ben Kahla, Hawreen Ahmed, Ali Ajwad, Muhammad Adnan","doi":"10.1038/s41598-025-13277-9","DOIUrl":"https://doi.org/10.1038/s41598-025-13277-9","url":null,"abstract":"<p><p>This exploratory study investigates the use of waste foundry sand (WFS), combined with supplement cementitious materials (SCMs), in concrete production. The Preliminary Investigation is based on three groups, where the first group studies different percentages of natural sand replacement with WFS (i.e. 5%, 10%, 15% and 20%), the second group analyses the addition of 5% silica fume with WFS, and the third group observes 10% metakaolin inclusion with WFS. The studied parameters include density, nondestructive test (UPV), compressive and tensile strength, acid resistance, and environmental benefit analysis. According to the results, the compressive strength of the concrete mix is enhanced by 17% by adding 20% WFS and 5% silica fume, and this value increases by 23% when adding an additional 10% metakaolin. Furthermore, the use of 20% WFS leads to a 3.27% decrease in the cost of concrete as compared to the control mix, with a decrease of 2.1% and 5.1% for silica and metakaolin-containing mixes, respectively.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27512"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}