Scientific Reports最新文献_第8页

Integrative metabolomics and proteomics reveal the effect and mechanism of Zi Qi decoction on alleviating liver fibrosis. 综合代谢组学和蛋白质组学揭示子芪汤缓解肝纤维化的作用和机制

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-80616-7

Xiaoying Chen, Yifan Wang, Xiaoyun Dou, Jie Wan, Jingwen Zhou, Tianci Li, Jun Yu, Fang Ye

{"title":"Integrative metabolomics and proteomics reveal the effect and mechanism of Zi Qi decoction on alleviating liver fibrosis.","authors":"Xiaoying Chen, Yifan Wang, Xiaoyun Dou, Jie Wan, Jingwen Zhou, Tianci Li, Jun Yu, Fang Ye","doi":"10.1038/s41598-024-80616-7","DOIUrl":"https://doi.org/10.1038/s41598-024-80616-7","url":null,"abstract":"Liver fibrosis is a common progressive liver disease that can cause liver dysfunction and lead to serious complications. Zi Qi decoction (ZQ) is a traditional formulation that exerts pharmacological effects on the treatment of liver fibrosis. However, precise intervention mechanisms remain unclear. The aim of this study was to synergistically harness proteomics and metabolomics techniques to elucidate the specific target of ZQ and its potential mechanism of action. A carbon tetrachloride (CCl4)-induced liver fibrosis mouse model was established. Subsequently, the protective effect of ZQ on liver fibrosis mice was evaluated according to histopathological examination and biochemical indicators. Quantitative proteomics based on data independent acquisition (DIA) and non-targeted metabolomic analyses revealed the pharmacodynamic mechanism of ZQ. In addition, various cellular and molecular assays were used to detect changes in glycolysis levels in LSECs and mouse liver fibrosis models. The study results showed that ZQ significantly alleviated CCl4-induced liver injury and fibrosis in mice. DIA-based quantitative proteomics and non-targeted metabolomics analyses indicated that ZQ treatment downregulated glycolysis-related proteins such as PKM2, PFKP, and HK2, while regulating glycolysis-related metabolites and pathways. In addition, ZQ down-regulated glycolytic activity in mice with liver fibrosis and in LSECs, and inhibited CXCL1 secretion and neutrophil recruitment. ZQ inhibited LSEC glycolysis and mitigated neutrophil infiltration, thereby playing a therapeutic role in liver fibrosis.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28943"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact. 病毒介导的海马神经粒蛋白增加可在大鼠受控皮质冲击模型中调节一个月的突触。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-77682-2

Sarah E Svirsky, Jeremy Henchir, Madison Parry, Erik Holets, Ting Zhang, George K Gittes, Shaun W Carlson, C Edward Dixon

{"title":"Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact.","authors":"Sarah E Svirsky, Jeremy Henchir, Madison Parry, Erik Holets, Ting Zhang, George K Gittes, Shaun W Carlson, C Edward Dixon","doi":"10.1038/s41598-024-77682-2","DOIUrl":"https://doi.org/10.1038/s41598-024-77682-2","url":null,"abstract":"Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plasticity, increases synaptogenesis and boosts cognitive abilities. Controlled cortical impact (CCI), an experimental traumatic brain injury (TBI) model, results in significantly reduced hippocampal Ng protein expression up to 4 weeks post-injury, supporting a strategy to increase Ng to improve function. In this study, hippocampal Ng expression was increased in adult, male Sham and CCI injured animals using intraparenchymal injection of adeno-associated virus (AAV) 30 min post-injury, thereby also affording the ability to differentiate endogenous and exogenous Ng. At 4 weeks, molecular, anatomical, and behavioral measures of synaptic plasticity were evaluated to determine the therapeutic potential of Ng modulation post-TBI. Increasing Ng had a TBI-dependent effect on hippocampal expression of synaptic proteins and dendritic spine morphology. Increasing Ng did not improve behavior across all outcomes in both Sham and CCI groups at the 4 week time-point. Overall, increasing Ng expression modulated protein expression and dendritic spine morphology, but exerted limited functional benefit after CCI. This study furthers our understanding of Ng, and mechanisms of cognitive dysfunction within the synapse sub-acutely after TBI.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28998"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional capacity matters for visuomotor adaptation to a virtual reality driving simulator. 注意能力与视觉运动对虚拟现实驾驶模拟器的适应有关。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-79392-1

Régis Lobjois, Sami Mecheri

{"title":"Attentional capacity matters for visuomotor adaptation to a virtual reality driving simulator.","authors":"Régis Lobjois, Sami Mecheri","doi":"10.1038/s41598-024-79392-1","DOIUrl":"https://doi.org/10.1038/s41598-024-79392-1","url":null,"abstract":"Studies have shown that adaptation to a virtual reality driving simulator takes time and that individuals differ widely in the time they need to adapt. The present study examined the relationship between attentional capacity and driving-simulator adaptation, with the hypothesis that individuals with better attentional capacity would exhibit more efficient adaptation to novel virtual driving circumstances. To this end, participants were asked to steer in a driving simulator through a series of 100 bends while keeping within a central demarcated zone. Adaptation was assessed from changes in steering behavior (steering performance: time spent within the zone, steering stability, steering reversal rate) over the course of the bends. Attentional capacity was assessed with two dynamic visual attention tasks (Multiple Object Tracking, MOT; Multiple Object Avoidance, MOA). Results showed effective adaptation to the simulator with repetition, as all steering-behavior variables improved. Both MOT and MOA scores significantly predicted adaptation, with MOT being a stronger predictor. Further analyses revealed that higher-capacity participants, but not their lower-capacity counterparts, produced more low-amplitude steering-wheel corrections early in the task, resulting in finer vehicle control and better performance later on. These findings provide new insights into adaptation to virtual reality simulators through the lens of attentional capacity.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28991"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical design approach enables optimised mechanical lysis for enhanced long-read soil metagenomics. 统计设计方法可优化机械裂解，增强长读数土壤元基因组学。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-80584-y

Daniel G Barber, Harry T Child, Gabrielle R Joslin, Lucy Wierzbicki, Richard K Tennant

{"title":"Statistical design approach enables optimised mechanical lysis for enhanced long-read soil metagenomics.","authors":"Daniel G Barber, Harry T Child, Gabrielle R Joslin, Lucy Wierzbicki, Richard K Tennant","doi":"10.1038/s41598-024-80584-y","DOIUrl":"https://doi.org/10.1038/s41598-024-80584-y","url":null,"abstract":"Metagenomic analysis has enabled insights into soil community structure and dynamics. Long-read sequencing for metagenomics can enhance microbial ecology by improving taxonomic classification, genome assembly, and functional annotation. However, protocols for purifying high-molecular weight DNA from soil are not yet optimised. We used a statistical design of experiments approach to enhance mechanical lysis of soil samples, increasing the length of purified DNA fragments. Low energy input into mechanical lysis improved DNA integrity, resulting in longer sequenced reads. Our optimized settings of 4 m s-1 for 10 s increased fragment length by 70% compared to the manufacturer's recommendations. Longer reads from low intensity lysis produced longer contiguous sequences after assembly, potentially improving a range of down-stream analyses. Importantly, there was minimal bias exhibited in the microbial community composition due to lysis efficiency variations. We therefore propose a framework for improving the fragment lengths of DNA purified from diverse soil types, improving soil science research with long-read sequencing.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28934"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating the impact of airport wildlife hazards management on realized wildlife strike risk. 估算机场野生动物危害管理对实现野生动物撞击风险的影响。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-79946-3

Levi Altringer, Michael J Begier, Jenny E Washburn, Stephanie A Shwiff

{"title":"Estimating the impact of airport wildlife hazards management on realized wildlife strike risk.","authors":"Levi Altringer, Michael J Begier, Jenny E Washburn, Stephanie A Shwiff","doi":"10.1038/s41598-024-79946-3","DOIUrl":"https://doi.org/10.1038/s41598-024-79946-3","url":null,"abstract":"Collisions between wildlife and aircraft, commonly referred to as wildlife strikes or bird strikes, are rare events that pose considerable safety and economic risks to the aviation industry. Given the potentially dramatic consequences of such events, airports scheduled for passenger service are required to conduct wildlife hazard assessments and implement wildlife hazard management plans for the purpose of mitigating wildlife strike risk. The evaluation of such management, however, is complicated by imperfect reporting that mediates the relationship between realized wildlife strike risk and wildlife strike metrics. In this paper, we shed light on such phenomena by investigating the staggered adoption of a federal wildlife hazards management program at joint-use airports across the contiguous United States. This research design allowed us to exploit variation in both management presence across airports, over time as well as variation in the quality of wildlife strike reporting within airports. As hypothesized, we found that wildlife hazards management intervention has a significant impact on the quality of reporting, as evidenced by a substantial increase in the number of civil strikes reported over the management period. Where pre-existing reporting mechanisms were more robust, however, we found that wildlife hazards management had a significant impact on realized wildlife strike risk as evidenced by a decrease in strike-induced economic damages among military aircraft. Overall, we found that the estimated economic benefits of the studied airport wildlife hazards management program were 7 times greater than the costs over the management period. Our results have important implications for the measurement of wildlife strike risk and the management of wildlife hazards at airports, as well as important insights pertaining to the use of observational data for causal inference, particularly in the context of risk management.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29018"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new insight into pilot-scale development of low-salinity polymer flood using an intelligent-based proxy model coupled with particle swarm optimization. 利用基于智能的代理模型和粒子群优化技术，对低盐度聚合物洪水的中试开发提出新见解。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-78210-y

Razieh Khosravi, Mohammad Simjoo, Mohammad Chahardowli

{"title":"A new insight into pilot-scale development of low-salinity polymer flood using an intelligent-based proxy model coupled with particle swarm optimization.","authors":"Razieh Khosravi, Mohammad Simjoo, Mohammad Chahardowli","doi":"10.1038/s41598-024-78210-y","DOIUrl":"https://doi.org/10.1038/s41598-024-78210-y","url":null,"abstract":"To successfully implement low-salinity polymer flooding in heterogeneous heavy oil reservoirs, it is crucial to comprehend the interactions between salinity, polymer properties, and reservoir characteristics. Artificial intelligence-driven proxy models can assist in identifying critical parameters and predicting performance outcomes, thereby enabling optimizing field-scale applications of this technique in heterogeneous heavy oil reservoirs. This study focused on developing a proxy model by coupling neural network and particle swarm optimization algorithms to analyze low-salinity polymer flooding. The model, trained with data from a pilot-scale dynamic simulator, achieved high predictive accuracy, featuring a regression value of 0.996 and a mean square error of 0.0011. It effectively forecasts key performance indicators such as oil recovery, water cut, and well bottom-hole pressure. The model identified injection rate as the most influential factor and polymer concentration as the least significant. Through the optimization of input parameters, the study established optimized values for the injection rate, injected fluid salinity, and polymer concentration at 1450 (bbl/day), 4000 ppm, and 1500 ppm, respectively. The optimization considers economic viability by maximizing net present value and addresses practical challenges of maintaining injectivity over time, making it a valuable tool for enhancing water-based recovery methods in oil field development.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29000"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of PET/CT radiomics for predicting survival outcomes in patients with pancreatic ductal adenocarcinoma. PET/CT 放射组学在预测胰腺导管腺癌患者生存结果方面的价值。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-77022-4

Yeon-Koo Kang, Seunggyun Ha, Ji Bong Jeong, So Won Oh

{"title":"The value of PET/CT radiomics for predicting survival outcomes in patients with pancreatic ductal adenocarcinoma.","authors":"Yeon-Koo Kang, Seunggyun Ha, Ji Bong Jeong, So Won Oh","doi":"10.1038/s41598-024-77022-4","DOIUrl":"https://doi.org/10.1038/s41598-024-77022-4","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis even without distant metastases, necessitating in-depth characterization of primary tumors for survival prediction. We assessed the feasibility of using FDG-PET/CT radiomics to predict overall survival (OS) in PDAC. This retrospective study included PDAC patients without distant metastasis who underwent FDG-PET/CT for initial staging. Primary tumors were segmented from FDG-PET/CT images, extracting 222 radiomics features. A radiomics-based risk score (Rad-score) was developed using Cox proportional hazards regression with LASSO to predict OS. The prognostic performance of the Rad-score was compared with a clinical model (demographics, disease stage, laboratory results) using Harrell's concordance index (C-index) and bootstrapping. 140 patients were included, with a mortality rate was 72.9% during follow-up (total population, 19.5 ± 19.2 months; survivors, 34.4 ± 28.8 months). Eleven radiomics features were significant for survival prediction. The Rad-score predicted OS with a C-index of 0.681 [95% CI, 0.632-0.731]. A model integrating clinical parameters and Rad-score outperformed the clinical-only model in predicting OS (C-index 0.740 [0.715-0.816] vs. 0.673 [0.650-0.766]; C-index difference 0.067 [0.014-0.113]; P < 0.001). These findings suggest that incorporating FDG-PET/CT radiomics into preexisting prognotic stratification paradiagm may enhance survival prediction in PDAC, warranting large-scale studies to confirm its applicability in clinical practice.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28958"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GCC2 promotes non-small cell lung cancer progression by maintaining Golgi apparatus integrity and stimulating EGFR signaling pathways. GCC2 通过维持高尔基体的完整性和刺激表皮生长因子受体信号通路，促进非小细胞肺癌的进展。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-75316-1

Min Sang Kim, Hyesun Jeong, Byeong Hyeon Choi, Jiho Park, Gun Seop Shin, Jik-Han Jung, Hyunku Shin, Ka-Won Kang, Ok Hwa Jeon, Jewon Yu, Ji-Ho Park, Yong Park, Yeonho Choi, Hyun Koo Kim, Sunghoi Hong

{"title":"GCC2 promotes non-small cell lung cancer progression by maintaining Golgi apparatus integrity and stimulating EGFR signaling pathways.","authors":"Min Sang Kim, Hyesun Jeong, Byeong Hyeon Choi, Jiho Park, Gun Seop Shin, Jik-Han Jung, Hyunku Shin, Ka-Won Kang, Ok Hwa Jeon, Jewon Yu, Ji-Ho Park, Yong Park, Yeonho Choi, Hyun Koo Kim, Sunghoi Hong","doi":"10.1038/s41598-024-75316-1","DOIUrl":"10.1038/s41598-024-75316-1","url":null,"abstract":"Fundamental changes in intracellular processes, such as overactive growth signaling pathways, are common in carcinomas and are targets of many cancer therapeutics. GRIP and coiled-coil containing 2 (GCC2) is a trans-Golgi network (TGN) golgin maintaining Golgi apparatus structure and regulating vesicle transport. Here, we found an aberrant overexpression of GCC2 in non-small cell lung cancer (NSCLC) and conducted shRNA-mediated gene knockdown to investigate the role of GCC2 in NSCLC progression. shRNA-mediated GCC2 knockdown suppressed NSCLC cell growth, migration, stemness, and epithelial-mesenchymal transition (EMT) in vitro and tumor growth in vivo. In addition, GCC2 knockdown suppressed cancer cell exosome secretion and the oncogenic capacity of cancer cell-derived exosomes. Mechanistically, GCC2 inhibition decreased epidermal growth factor receptor (EGFR) expression and downstream growth and proliferation signaling. Furthermore, GCC2 inhibition compromised Golgi structural integrity in cancer cells, indicating a functional role of GCC2 in regulating intracellular trafficking and signaling to promote lung cancer progression. Together, these findings suggest GCC2 as a potential therapeutic target for the treatment of NSCLC.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28926"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-task vision transformer for rapid and accurate intracerebral hemorrhage CT image classification. 用于快速准确地进行脑出血 CT 图像分类的双任务视觉转换器。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-79090-y

Jialiang Fan, Xinhui Fan, Chengyan Song, Xiaofan Wang, Bingdong Feng, Lucan Li, Guoyu Lu

{"title":"Dual-task vision transformer for rapid and accurate intracerebral hemorrhage CT image classification.","authors":"Jialiang Fan, Xinhui Fan, Chengyan Song, Xiaofan Wang, Bingdong Feng, Lucan Li, Guoyu Lu","doi":"10.1038/s41598-024-79090-y","DOIUrl":"10.1038/s41598-024-79090-y","url":null,"abstract":"Intracerebral hemorrhage (ICH) is a severe and sudden medical condition caused by the rupture of blood vessels in the brain, leading to permanent damage to brain tissue and often resulting in functional disabilities or death in patients. Diagnosis and analysis of ICH typically rely on brain CT imaging. Given the urgency of ICH conditions, early treatment is crucial, necessitating rapid analysis of CT images to formulate tailored treatment plans. However, the complexity of ICH CT images and the frequent scarcity of specialist radiologists pose significant challenges. Therefore, we collect a dataset from the real world for ICH and normal classification and three types of ICH image classification based on the hemorrhage location, i.e., Deep, Subcortical, and Lobar. In addition, we propose a neural network structure, dual-task vision transformer (DTViT), for the automated classification and diagnosis of ICH images. The DTViT deploys the encoder from the Vision Transformer (ViT), employing attention mechanisms for feature extraction from CT images. The proposed DTViT framework also incorporates two multilayer perception (MLP)-based decoders to simultaneously identify the presence of ICH and classify the three types of hemorrhage locations. Experimental results demonstrate that DTViT performs well on the real-world test dataset.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28920"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of phononic crystal for enhancing low-frequency sound absorption in mufflers. 设计声子晶体，增强消声器的低频吸音效果。

IF 3.8 2区综合性期刊

Scientific Reports Pub Date : 2024-11-22 DOI: 10.1038/s41598-024-79762-9

Yang Bai, Yuehua Chen, Jiahui Zheng

{"title":"Design of phononic crystal for enhancing low-frequency sound absorption in mufflers.","authors":"Yang Bai, Yuehua Chen, Jiahui Zheng","doi":"10.1038/s41598-024-79762-9","DOIUrl":"10.1038/s41598-024-79762-9","url":null,"abstract":"To enhance the low-frequency sound absorption capabilities of expansion chamber mufflers, a novel Helmholtz-ring phononic crystal cell was developed. This innovative design integrates ring Helmholtz resonators as the phononic crystal scatterer, which is periodically arranged within the expansion chamber of a muffler to achieve enhanced sound attenuation at deep sub-wavelength scales. The transmission loss characteristics of the phononic crystal muffler were thoroughly examined and found to reveal a pronounced enhancement in sound absorption within the low-frequency bandgap. A critical aspect of this study was the analysis of the influence of defect states on transmission loss of the muffler. The introduction of defect states significantly expanded the sound attenuation bandwidth, effectively compensating for reduced sound absorption performance of the muffler outside the bandgap. The proposed phononic crystal muffler demonstrated a marked improvement in both transmission loss and aerodynamic performance compared to the traditional expansion chamber muffler. Notably, the sound attenuation was further augmented when in defective states. Corresponding experimental investigations were conducted and confirmed the effectiveness of the phononic crystal muffler within its designated bandgap range. This research presents a new way for the development of more efficient noise control solutions.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"28921"},"PeriodicalIF":3.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0