Scientific Reports最新文献

{"title":"The analysis of molten salt energy storage mode with multi-steam sources heating in thermal power unit peak shaving operation.","authors":"Lin-Kui Feng, Yao-Fei Feng, Ke Lu, Ping Wang, Kai Zhao, Zhi-de Gu, Yan-Nan Ren, Sheng-Lu Xie","doi":"10.1038/s41598-025-95901-2","DOIUrl":"https://doi.org/10.1038/s41598-025-95901-2","url":null,"abstract":"<p><p>A 350 MW cogeneration unit was selected as the research object to investigate a molten salt energy storage system. Key evaluation indicators, including peak shaving capacity, thermal efficiency, equivalent round-trip efficiency, and comprehensive coal consumption, were analyzed under heat storage-release strategies involving single-steam source and multi-steam source heating, combined with steam grade and steam split ratio. The thermoelectric characteristic curve of the unit during the heat storage-release phase was determined based on the storage-release characteristics of the molten salt system. The results indicate that under heat storage mode, similar peak shaving depths are achieved with both single-steam source and multi-steam source heating strategies. However, thermal efficiency is higher with the multi-steam source strategy, and peak shaving capacity improves with an increased steam split ratio. During heat release mode, higher peak shaving capacity is achieved when steam is matched with the grade of cold reheat steam.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11305"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central retinal artery catheterization for retinal artery occlusion with balanced salt solution.","authors":"Xiangdong Luo, Xiaoying Wang, Yang Li, Xiaoyan Chen, Bin Wang, Qinrui Hu, Xiaoxin Li","doi":"10.1038/s41598-025-95238-w","DOIUrl":"https://doi.org/10.1038/s41598-025-95238-w","url":null,"abstract":"<p><p>To assess the efficacy and safety of vitrectomy combined with central retinal artery Cannulation in the treatment of retinal artery occlusion. Retrospective case analysis was conducted from April 2020 to March 2022 at the Xiamen Eye Center of Xiamen University, for patients diagnosed with central retinal artery occlusion or branch retinal artery obstruction, who underwent retinal artery Cannulation within 72 h of onset. All patients underwent pre- and postoperative visual acuity, intraocular pressure, fundus photography, optical coherence tomography, wide-angle fluorescein angiography, and visual field examination. Nine patients (6 males and 3 females) with an average age of 46 ± 28.6 years (range: 16-77 years) were included. Seven eyes were diagnosed with central retinal artery occlusion, and two eyes with branch retinal artery occlusion. The average time from onset to surgery was 40.1 h. One month after treatment, logMAR visual acuity improved in all 9 eyes of 9 patients, with a statistically significant difference (P = 0.012). Fluorescein angiography showed that postoperative arm-retinal circulation time was shortened in 5 cases (5/9, 55%) and unchanged in 4 cases (4/9, 45%). After surgery, patients generally report an improvement in vision, as well as an enhancement in their field of vision. Retinal artery Cannulation can effectively improve visual acuity and visual field, shorten the arm-retinal circulation time, and promote the recovery of retinal circulation.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11210"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative and oncological outcomes of single position retroperitoneoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma.","authors":"Jiaqiang Chen, Luxin Zhang, Zhihong Dai, Cheng Chang, Heyao Tong, Hepeng Cui, Zhuwei Song, Bo Fan, Zhiyu Liu, Liang Wang","doi":"10.1038/s41598-025-96261-7","DOIUrl":"https://doi.org/10.1038/s41598-025-96261-7","url":null,"abstract":"<p><p>Radical nephroureterectomy (RNU) is the gold standard therapy for patients with upper urinary tract urothelial carcinoma (UTUC). In this study, we compared the effect of two surgical techniques, single-position complete retroperitoneoscopic radical nephroureterectomy (SCRNU) and laparoscopic nephroureterectomy with open bladder cuff excision (LNOBE), on perioperative and long-term oncological outcomes in UTUC patients. We retrospectively collected information on baseline characteristics, clinicopathological characteristics, surgical approaches, perioperative data, and survival outcomes from 174 patients who underwent RNU for UTUC between January 2018 and June 2023 in our center. The data were analyzed using the Mann-Whitney test, Fisher's exact test, Chi-square test. Linear regressions were applied to explore the effect of surgery approach on the continuous outcomes. Log-rank test and Kaplan-Meier survival curves were plotted to describe the survival outcome. Univariate and Multivariate Cox regressions were conducted to explore the independent prognostic factors. To address potential selection bias, we also employed an Inverse Probability of Treatment Weighting (IPTW) strategy. Patients who underwent SCRNU had shorter operative times (p < 0.001), reduced estimated blood loss (p < 0.001), less drainage on the first postoperative day (p = 0.009), shorter hospital stays (p = 0.001), and better intravesical recurrence-free survival than those who underwent LNOBE (IVRFS, HR: 0.17, 95% CI: 0.07-0.44, p = 0.007). Moreover, SCRNU was confirmed to be a protective factor for IVRFS after IPTW-adjusted Cox regression analysis was performed (HR: 0.17, 95% CI: 0.04-0.77, p = 0.021). SCRNU not only avoids intraoperative repositioning but also improves perioperative outcomes, including the reduction of operative time, blood loss, and length of hospital stay, and is associated with better IVRFS.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11221"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral inflammatory factors as prognostic predictors for first-line PD-1/PD-L1 inhibitors in advanced non-small cell lung cancer.","authors":"Chen-Xing Jin, Yan-Song Liu, He-Nan Qin, Yi-Bin Teng, Rui Sun, Zhong-Jing Ma, A-Man Wang, Ji-Wei Liu","doi":"10.1038/s41598-024-84469-y","DOIUrl":"https://doi.org/10.1038/s41598-024-84469-y","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have significantly improved the efficacy and prognosis of patients with non-small cell lung cancer (NSCLC). However, there remains a lack of optimal predictive biomarkers for assessing the response of ICIs. This study aimed to evaluate peripheral inflammatory factors as potential predictive biomarkers for NSCLC patients treated with ICIs. We retrospectively analyzed the correlation between peripheral inflammatory factors and the efficacy and prognosis of 124 patients with driver gene-negative advanced NSCLC who received first-line ICIs at our center from September 2018 to June 2022. Progression-free survival (PFS) was estimated using the Kaplan-Meier method. The association between the factors and multiple endpoints were investigated using univariate and multivariate analyses. A total of 124 patients were enrolled in this study. The objective response rate (ORR) was 49.2% and the disease control rate (DCR) was 97.6%, respectively. The median PFS was 12.7 months. The ORR differed statistically between groups based on the NLR, SII, with higher ORR observed in patients with an NLR ratio < 0.68, SII at 6 weeks < 531.26, and SII ratio < 0.74 (p < 0.05). The univariate analysis indicated that ECOG 0-1, smoking, NLR at 6 weeks < 2.72, NLR ratio < 0.68, LMR < 1.34, LMR ratio ≥ 1.38, and SII at 6 weeks < 531.26 were associated with longer PFS (p < 0.05). The multivariate analysis revealed that smoking (p = 0.013), baseline LMR (p = 0.015), and SII at 6 weeks (p = 0.010) were independent predictors of PFS. NLR, LMR, and SII maybe biomarkers for predicting the efficacy and prognosis of first-line ICIs therapy in driver gene-negative advanced NSCLC.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11206"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase transitions and chemical segregation in Ge-rich GST based phase change memory cells.","authors":"Sijia Ran, Elisa Petroni, Luca Laurin, Matteo Baldo, Andrea Serafini, Minh-Anh Luong, Alessandro Motta, Andrea Redaelli, Alain Claverie","doi":"10.1038/s41598-025-95227-z","DOIUrl":"https://doi.org/10.1038/s41598-025-95227-z","url":null,"abstract":"<p><p>In this work, a detailed chemical and crystallographic analysis of basic logic and a few selected intermediate RESET states of Ge-rich Ge-Sb-Te-based (GST) phase-change memories (PCM) is presented, with a particular focus on the understanding of the microscopic mechanisms underlying their electrical characteristics. We demonstrate that Ge-rich GST-based PCM store the information not only in their crystalline or amorphous phase, as in conventional PCM based on Ge₂Sb₂Te₅, but also in their active material stoichiometries: the amorphous phase is characterized by a Ge-rich composition, guaranteeing automotive-compliant retention, while the crystalline phase shows a composite structure, made of cubic GST and rhombohedral Sb grains, the latter mostly found close to the heater. This switching of composition explains the high temperature retention capability of Ge-rich GST cells and their preserved good functionality in the high conductive state. Analysis of intermediate RESET states unveils the microscopic details of these physical and chemical transitions, giving insights on the physical origin of the electrical characteristics of Ge-rich GST-based PCM.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11357"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarkers in patients with familial cavernous malformation and their first-degree relatives: a cross-sectional study.","authors":"Chunwang Li, Shuna Huang, Qixuan Li, Lingyun Zhuo, Yaqing Kang, Penghui Liu, Weilin Huang, Ke Ma, Xinru Lin, Weiheng Zhuang, Darong Chen, Huimin Wang, Lingjun Yan, Dengliang Wang, Yuanxiang Lin, Dezhi Kang, Fuxin Lin","doi":"10.1038/s41598-025-91141-6","DOIUrl":"https://doi.org/10.1038/s41598-025-91141-6","url":null,"abstract":"<p><p>Familial cerebral cavernous malformation (FCCM), especially severe cases, impose a heavy physical and psychological burden on patients and their families. To explore the differences in plasma biomarker levels between patients with FCCM and their healthy first-degree relatives (FDRs) and between FCCM patients with and without severe chronic disease aggressiveness (CDA). In a cross - sectional study, magnetic resonance imaging (MRI) scanning and genetic testing were performed in patients with multiple CCMs and their FDRs. Subsequently, sixty-seven plasma biomarkers were tested using a customised multiplex bead immunoassay kit. Univariate and multivariate unconditional logistic regression analyses were conducted to determine the associations between plasma factors and the risk of developing FCCM and severe CDA. Receiver operating characteristic (ROC) curves were generated for each independent risk factor. As a result, plasma factors of 37 patients with FCCM and 37 FDRs were examined. Low CD31 (P < 0.001) and BDNF levels (P = 0.013) were independent risk factors for FCCM. The best model was achieved by combining the results of CD31 and BDNF (AUC = 0.845, sensitivity 0.838, specificity 0.784, cutoff score - 4.295) to distinguish patients with FCCM from healthy FDRs. Low Serpin E1/PAI-1 (P = 0.011) and high ROBO4 levels (P = 0.013) were independent risk factors for severe CDA in patients with FCCM. The best model was achieved by combining the results of Serpin E1/PAI-1 and ROBO4 levels (AUC = 0.913, sensitivity 1.000, specificity 0.760, cutoff score - 0.525) to identify patients with FCCM and severe CDA. In summary, the plasma concentrations of CD31 and BDNF seem to be lower in patients with FCCM than in their healthy FDRs. Low Serpin E1/PAI-1 and high ROBO4 concentrations may be correlated with high lesion burden and risk of recurrent bleeding.Trial registration: ClinicalTrials.gov Identifier: NCT03467295.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11284"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and optimization of azo dyes degrading microbes isolated from textile effluent.","authors":"Arshiya Khan, Anuraj Nayarisseri, Sanjeev Kumar Singh","doi":"10.1038/s41598-025-95359-2","DOIUrl":"https://doi.org/10.1038/s41598-025-95359-2","url":null,"abstract":"<p><p>Azo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks. This research aimed to isolate and identify bacterial strains from textile wastewater that can decolorize azo dyes. After the subsequent screening of 89 isolates, 4 novel strains were identified utilizing the 16S rRNA gene sequencing technique that could effectively decolorize and degrade azo dyes, methyl red, direct yellow 12, and acid black 210. A thorough assessment of physicochemical parameters was conducted to optimize for maximum decolorization for all four strains. At pH 7, 37° C, and 50 mg/L dye concentration, the maximum decolorization for methyl red, direct yellow 12, and acid black 210 was 79.09% > 72.20% > 64.76%; 84.45% > 62.59% > 54.29%; 83.12% > 70.22% > 61.42%; and 92.71% > 83.02% > 69.84%, for isolate 1, isolate 2, isolate 3, and isolate 4, respectively. The novel strains belonged to the Sphingomonas, Pseudomonas, Shewanella, and Priestia species. The unique sequences of these bacterial strains have been submitted to the GenBank database under the accession numbers \"OQ202071\", \"PP708911\", \"PP708909\", and \"PP086977,\" respectively. Further, an enzyme study and statistical optimization of Priestia flexa species was performed. A Central Composite Design and Response Surface Methodology has been applied for synergistic effects of process parameters namely pH (5-9), initial dye concentration (100-250 mg/L), and temperature (25°-45° C) on the decolorization of the model dyes. The regression analysis indicated a strong correlation between the experimental data and the second-order polynomial supported by a high coefficient of determination (R²). For all three dyes analyzed, the difference between the experimental and predicted values was found to be less than 10%. Fourier Transform Infrared spectroscopy was further employed to analyze and confirm the degradation of the three dyes.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11241"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of lomerizine on vasculopathy in Fabry disease.","authors":"Jong Bin Choi, Hyo-Sang Do, Dong-Won Seol, Hee-Young Yang, Taek-Min Kim, Youkyeong Gloria Byun, Jae-Min Park, Heounjeong Go, Jungjoo Park, Won-Suk Chung, Jae Myoung Suh, Beom Hee Lee, Gabbine Wee, Yong-Mahn Han","doi":"10.1038/s41598-025-94795-4","DOIUrl":"https://doi.org/10.1038/s41598-025-94795-4","url":null,"abstract":"<p><p>Fabry disease (FD) is a lysosomal storage disorder in which α-galactosidase (GLA) deficiency leads to a build-up of globo-triaosylceramide (Gb3) in various cell types. Gb3 accumulation leads to the abnormalities of microvascular function associated with FD. Previously, we discovered significant abnormalities in vascular endothelial cells (VECs) derived from FD-induced pluripotent stem cells. We then used a cell-based system to screen a group of clinical compounds for candidates capable of rescuing those abnormalities. Lomerizine was one of the most promising candidates because it alleviated a variety of FD-associated phenotypes both in vitro and in vivo. Lomerizine reduced mitochondria Ca²⁺ levels, ROS generation, and the maximal respiration of FD-VECs in vitro. This led to a suppression of the endothelial-to-mesenchymal transition (EndMT) and rescued FD-VEC function. Furthermore, FD-model mice (Gla-/-/TSP1Tg) treated orally with lomerizine for 6 months showed clear improvement of several FD phenotypes, including left ventricular hypertrophy, renal fibrosis, anhidrosis, and heat intolerance. Thus, our results suggest lomerizine as a novel candidate for FD therapy.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11355"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical reinforcement learning with central pattern generator for enabling a quadruped robot simulator to walk on a variety of terrains.","authors":"Toshiki Watanabe, Akihiro Kubo, Kai Tsunoda, Tatsuya Matsuba, Shintaro Akatsuka, Yukihiro Noda, Hiroaki Kioka, Jin Izawa, Shin Ishii, Yutaka Nakamura","doi":"10.1038/s41598-025-94163-2","DOIUrl":"https://doi.org/10.1038/s41598-025-94163-2","url":null,"abstract":"<p><p>We present a data-driven deep reinforcement learning (DRL) method for the optimization of a hierarchically structured control policy that includes the central pattern generator. This method, which is as a whole referred to as the hierarchical reinforcement learning with the central pattern generator (HRL-CPG), is then evaluated with the expectation of its applicability in real robot controls. We observed that stable gait motions were gained in a reasonably small number of trials and errors. Thus, it can be deduced that our HRL-CPG can be a candidate DRL method that enables dynamical systems such as real or realistic robots to adapt to a variety of environments within a moderate physical time.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11262"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous determination of lesinurad and co-administered drugs used in management of gout comorbidities to uncover potential pharmacokinetic interaction in rat plasma.","authors":"Hadeel A Khalil, Amira F El-Yazbi, Eman I El-Kimary, Mohamed A Elrewiny, Ahmed F El-Yazbi, Tarek S Belal","doi":"10.1038/s41598-025-93680-4","DOIUrl":"https://doi.org/10.1038/s41598-025-93680-4","url":null,"abstract":"<p><p>Gout is one of the most prevalent forms of arthritis that is usually accompanied by other comorbidities. For this reason, multiple drugs are routinely prescribed for gout patients, which may affect the clinical course outcomes, and increase the risk of drug-drug interactions. This work presents a novel, simple, and sensitive high performance liquid chromatography (HPLC) method for the simultaneous determination of lesinurad (LES) and other co-administered drugs that are subject to potential pharmacokinetic interactions such as etoricoxib (ETC), eplerenone (EPL), and amiodarone (AMD) in rat plasma. Moreover, a pharmacokinetic study was conducted by co-administration of LES and ETC to rats to assess any possible alteration in their pharmacokinetic profiles and the obtained samples were analyzed using the developed method. Chromatographic separation was achieved using a gradient elution of a mobile phase consisting of acetonitrile and potassium dihydrogen orthophosphate buffer, pH 4.2 on a Zorbax Eclipse Plus C18 (4.6 × 250 mm, 5 μm particle size) column. The developed method exhibits adequate sensitivity with a LLOQ of 100 ng/mL and was successfully validated as per the FDA bioanalytical guidelines and was found to be linear over the range from 100 to 50,000 ng/mL for all the selected drugs. The results of the pharmacokinetic study showed an increase in the area under the curve (AUC) of each of the two drugs (LES and ETC) following the repeated administration of the other. This raises concerns of the possible renal injurious effect of ETC when co-prescribed with LES. Moreover, this work uncovers the necessity for therapeutic dose adjustment or increased clinical vigilance for side effects and/or lack of efficacy upon concomitant administration of the selected drugs to gout patients.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"11238"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}