Scientific Reports最新文献

{"title":"Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats.","authors":"Indu Raghunath, Marina Koland, Suprit D Saoji, Sarad Pawar Naik Bukke, N Shridhar Deshpande, Varsha Augustin, Nilesh Rarokar, Chandrashekar Thalluri","doi":"10.1038/s41598-025-05137-3","DOIUrl":"https://doi.org/10.1038/s41598-025-05137-3","url":null,"abstract":"<p><p>The oral administration of insulin offers significant clinical benefits due to its simplicity. This study evaluated piperine's efficacy in improving insulin's intestinal absorption in Wistar rats. Confocal microscopy demonstrated that prolonged retention of insulin-loaded chitosan-coated solid lipid nanoparticles (Ch-In-SLNs) on intestinal mucosa was due to chitosan's mucoadhesive properties. These studies also revealed Ch-In-SLNs permeation in rat intestinal segments. Piperine enhanced the permeation of insulin-loaded nanoparticles, with more particles transported into deeper intestinal layers. The study assessed Ch-In-SLNs with piperine administered orally to diabetic rats. The formulated SLN's effectiveness was evaluated in vivo in overnight-fasted Wistar rats. Male Wistar rats (n = 5) were divided into 8 groups, with the first as diabetic control, and others receiving various treatments, including blank SLN, oral insulin solution (25 IU/kg), subcutaneous (SC) insulin (5 IU/kg), and insulin nanoformulations (25 IU/kg and 50 IU/kg with and without piperine, respectively). Ch-In-SLN with piperine showed a statistically significant reduction (p < 0.05) in blood glucose levels in streptozotocin-induced (STZ) diabetic rats compared to SLNs without piperine and SC insulin. The Ch-In-SLN with piperine formulation demonstrated a noteworthy correlation between pharmacokinetics (PK) and pharmacodynamics (PD). This approach could replace traditional insulin injections and mitigate associated side effects, simplifying insulin therapy.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22771"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-leadership drives employee creativity through emotional exhaustion with regulatory focus as a moderator.","authors":"Liang Zhao, Hao Chen, Yichao Sun, Maya Luo, Peng Gao","doi":"10.1038/s41598-025-05131-9","DOIUrl":"https://doi.org/10.1038/s41598-025-05131-9","url":null,"abstract":"<p><p>In the digital age, e-leadership has emerged as a critical driver of employee creativity, yet the underlying mechanisms and boundary conditions remain underexplored. This study aimed to elucidate the relationship between E-leadership and employee creativity by examining the mediating role of emotional exhaustion and the moderating influences of promotion and prevention regulatory foci. Data were collected via a questionnaire survey administered to 366 employees within China's Information and Communication Technology (ICT) sector, and the data were analyzed using hierarchical regression and bootstrapping techniques. Results demonstrate that E-leadership influences creativity through multiple concurrent pathways: a direct positive effect (β = 0.28, p 0.01, accounting for 66.7% of total effect) and an indirect effect mediated through reduced emotional exhaustion (β = 0.14, 95% CI [0.08, 0.21], representing 33.3% of total effect). These relationships are significantly moderated by regulatory focus, with promotion focus attenuating the negative association between E-leadership and emotional exhaustion (interaction β = 0.14, p = 0.01) and prevention focus exacerbating the detrimental impact of emotional exhaustion on creativity (interaction β = -0.20, p 0.01). These findings advance leadership theory by revealing how cognitive-motivational factors shape e-leadership effectiveness, with practical implications for mitigating burnout in technology-mediated work environments.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22814"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-to-end feature fusion for jointly optimized speech enhancement and automatic speech recognition.","authors":"Mohamed Medani, Nasir Saleem, Fethi Fkih, Manal Abdullah Alohali, Hela Elmannai, Sami Bourouis","doi":"10.1038/s41598-025-05057-2","DOIUrl":"https://doi.org/10.1038/s41598-025-05057-2","url":null,"abstract":"<p><p>Speech enhancement (SE) and automatic speech recognition (ASR) in real-time processing involve improving the quality and intelligibility of speech signals on the fly, ensuring accurate transcription as the speech unfolds. SE eliminates unwanted background noise from target speech in environments with high background noise levels, which is crucial in real-time ASR. This study first proposes a speech enhancement network based on an attentional-codec model. Its primary objective is to suppress noise in the target speech with minimal distortion. However, excessive noise suppression in the enhanced speech can potentially diminish the effectiveness of downstream ASR systems by excluding crucial latent information. While joint SE and ASR techniques have shown promise for achieving robust end-to-end ASR, they traditionally rely on using the enhanced features as inputs to the ASR systems. To address this limitation, our study uses a dynamic fusion approach. This approach integrates both the enhanced features and the raw noisy features, aiming to eliminate noise signals from the enhanced target speech while simultaneously learning fine details from the noisy signals. This fusion approach seeks to mitigate speech distortions, enhancing the overall performance of the ASR system. The proposed model consists of an attentional codec equipped with a causal attention mechanism for SE, a GRU-based fusion network, and an ASR system. The SE network uses a modified Gated Recurrent Unit (GRU), where the traditional hyperbolic tangent (tanh) is replaced by an attention-based rectified linear unit (AReLU). The SE experiments consistently obtain better speech quality, intelligibility, and noise suppression in matched and unmatched conditions than the baselines. With the LibriSpeech database, the proposed SE obtains better STOI (19.81%) and PESQ (28.97%) in matched conditions and unmatched conditions (STOI: 17.27% and PESQ: 27.51%). The joint training framework for robust end-to-end ASR evaluates the character error rate (CER). The ASR results find that the joint training framework reduces the error rate from 32.99% (average noisy signals) to 13.52% (with the proposed SE and joint training for ASR).</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22892"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating health literacy and pandemic concerns in saudi healthcare students and implications for future preparedness: a cross-sectional analysis.","authors":"Fatchima Laouali Moussa, Mahaman Laouali Moussa, Ali Kerari, Hussain Ahmed Sufyani, Saleh Abdulkarim Khallaf, Ahmad Abdullah Albarqi, Yahia Ahmad Oqdi, Hamad Samran Alharbi, Ayman Mohammed Alhubayshi, Zafarul Hasan","doi":"10.1038/s41598-025-06326-w","DOIUrl":"https://doi.org/10.1038/s41598-025-06326-w","url":null,"abstract":"<p><p>The COVID-19 pandemic has profoundly impacted healthcare systems and the training of healthcare professionals globally. This cross-sectional study investigated the relationship between fear of COVID-19 and health literacy among 322 nursing and medical students in Saudi Arabia. Participants, selected through stratified random sampling, completed the Fear of COVID-19 Scale (FCoV-19 S) and the short-form Health Literacy (HLS-SF12) questionnaires. The results revealed that age, gender, academic year, and health literacy levels significantly influenced fear scores. Higher health literacy was associated with lower levels of fear, emphasizing the importance of education in alleviating pandemic-related anxiety. Key predictors of fear included personal COVID-19 experiences, perceived likelihood of infection, and symptom severity, while knowledge of prevention served as a protective factor. These findings can inform interventions aimed at enhancing health literacy and mental well-being among healthcare students, equipping them for future public health challenges. The study highlights the necessity for targeted education and communication strategies to effectively reduce fear during pandemics. Future research should examine additional factors influencing fear and evaluate the effectiveness of educational interventions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22888"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing concrete strength for sustainability using a machine learning approach to improve mechanical performance.","authors":"Amir Khan, Aneel Manan, Muhammad Umar, Mudassir Mehmood, Kennedy C Onyelowe, Krishna Prakash Arunachalam","doi":"10.1038/s41598-025-02648-x","DOIUrl":"https://doi.org/10.1038/s41598-025-02648-x","url":null,"abstract":"<p><p>The construction industry faces growing pressure to adopt sustainable practices due to the environmental burden of concrete waste and the overuse of natural resources. One promising solution is the use of recycled concrete aggregate (RCA) as a partial or full replacement for natural aggregates. However, the inconsistent performance of RCA concrete due to differences in source material, composition, and mix design poses challenges for its widespread adoption. This study leverages machine learning (ML) to predict the mechanical performance of RCA concrete and identify the key variables influencing its strength. A robust dataset of 583 samples was compiled from the literature, featuring 10 input parameters and two key outputs: compressive strength (Fc) and split tensile strength (STS). Three ML models Extreme Gradient Boosting (XGBoost), Decision Tree, and K-Nearest Neighbors (KNN) were developed and evaluated using metrics such as R², RMSE, MAE, and MAPE. Among the models tested, XGBoost demonstrated the best performance, achieving test R² values of 0.86 for Fc and 0.88 for STS, with RMSEs of 8.32 MPa and 0.55 MPa, respectively. Decision Tree followed with moderate accuracy, while KNN showed limited predictive power. To understand feature influence, SHAP analysis was conducted, revealing the water-to-cement ratio and cement content as the most critical factors impacting strength. By integrating ML with recycled material use, this study presents a reliable predictive approach for RCA-based concrete performance offering practical insights to engineers and aiding in the transition toward greener construction solutions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23067"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the quality management of hospital environmental surfaces through the application of a multidisciplinary team model.","authors":"Shuangshuang Xu, Ani Sun, Huaqian Wang, Yuchun Zhu, Guanglei Wang, Lu Liu, Hongwei Zheng","doi":"10.1038/s41598-025-08823-4","DOIUrl":"https://doi.org/10.1038/s41598-025-08823-4","url":null,"abstract":"<p><p>Nosocomial infections have become one of the major causes of mortality among hospitalized patients. To improve the quality of cleaning and disinfection for hospital environmental surfaces, we conducted a multidisciplinary team (MDT) intervention study with a non-randomized control group in a general hospital in China. The MDT comprised members with educational backgrounds in nursing, clinical medicine, public health, or laboratory science. Fluorescent labeling and microbiological sampling were used to evaluate the cleaning levels of environmental surfaces. A questionnaire was employed to assess cleaners' knowledge awareness, cleaners' misconduct was examined via on-site inspection, and detection of multi-drug resistant organisms and calculation of hospital-acquired infection (HAI) rate were also conducted. After MDT intervention, cleaning levels were significantly improved (e.g., total cleaning rate was increased from 66.75 to 82.10%, P < 0.001), cleaners' knowledge awareness was enhanced (total qualified rate was increased from 51.61 to 83.15%, P < 0.01), misconduct rate was reduced (from 38.48 to 10.43%, P < 0.001), and detection rates of multi-drug resistant organisms and the HAI rate (from 1.29 to 0.88%, P < 0.01) were both significantly reduced. Our study demonstrates that the MDT model shows promising potential in the management of cleaning and disinfection in hospital environmental surfaces.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23035"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of gaps in direct oral anticoagulants (DOACs) management in an outpatient underserved clinic: a cross-sectional study.","authors":"Bader M Alghamdi, Sara L Rogers","doi":"10.1038/s41598-025-07712-0","DOIUrl":"https://doi.org/10.1038/s41598-025-07712-0","url":null,"abstract":"<p><p>DOACs are widely used for stroke prevention in non-valvular atrial fibrillation and treatment of thromboembolism, but gaps in their management can lead to adverse outcomes. In outpatient, underserved clinics, challenges such as inappropriate dosing, lack of monitoring, and improper drug combinations may be more pronounced, necessitating evaluation to optimize patient care and reduce risks. This study assessed the appropriateness of DOAC use and dosing per FDA guidelines, considering renal function, hepatic function, and drug-drug interactions. Secondary objectives focused on evaluating inappropriate aspirin use alongside DOACs. This was a single-center retrospective cohort study. The study was conducted at Texas A&M Health Family Care Clinic (12/24/2022-12/24/2023). Older than 18 years of age and had active prescription of DOAC (apixaban, dabigatran, edoxaban, or rivaroxaban). A total of 125 DOAC patients were included. Inappropriate dosing based on renal function occurred in 16% of cases. DOAC use was unsuitable in two patients with severe hepatic impairment. Major drug interactions resulted in two instances of inappropriate DOAC use. Additionally, about 61% of aspirin usage involved inappropriate combinations with DOACs, as shown in Fig. 1. The study's findings indicate that anticoagulation management in our ambulatory care setting has the potential for further optimization.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23064"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation of blasting stress wave attenuation in sandstone with columnar charging using high-speed DIC technique.","authors":"Li Chengjie, Wang Mengqi, Xie Shoudong, An Qi, Yu Mengyao","doi":"10.1038/s41598-025-02662-z","DOIUrl":"https://doi.org/10.1038/s41598-025-02662-z","url":null,"abstract":"<p><p>The propagation and attenuation characteristics of blast stress waves in geotechnical media directly influence the fracture behavior of the medium and serve as a crucial basis for optimizing blasting parameter design. To examine the attenuation characteristics of cylindrical blast waves in rocks, the indoor blasting experiments were conducted using sandstone with cylindrical charges. Digital image correlation technology was employed to successfully capture the full-field strain evolution around the borehole during blasting, and the strain-time curves of the rock surrounding the borehole were obtained. To account for the influence of blasting stress wave loading rates on dynamic elastic modulus, Split Hopkinson Pressure Bar tests were performed to establish a precise relationship between dynamic elastic modulus and strain rate. By analyzing the attenuation of the peak strain, a stress wave attenuation equation within the fractured zone was developed, and the stress wave attenuation index was examined. The results indicated that the experimental method effectively simulated the blasting process of cylindrical charges. The strain wave propagation was accompanied by energy transformation, where the descending phase of the strain-time curve represented the rapid energy input to the rock near the borehole due to blast loading, whereas the ascending phase reflected the radial release of elastic energy, further promoting the development of circumferential cracks, albeit at a lower energy release rate than the descending phase. As the distance from the blast center increased, both the dynamic elastic modulus and strain rate of the rock under blast loading decreased, leading to differences between the attenuation characteristics of stress waves and strain waves, with the former following a power function decay. The complex nature of stress wave attenuation in rocks was primarily governed by physical attenuation properties, with the physical attenuation index exceeding the geometric attenuation index in crushed and cracked zones. Finally, the accuracy of the stress wave attenuation equation and the reliability of the experimental method were validated by analyzing the fracture morphology of the blasted specimens and the extent of the cracked zone.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22515"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on mechanical properties of composite materials of concrete and foamed cement under uniaxial compression.","authors":"Yue Cao, Zheng Kong, Yadong Zheng, Zhijun Xu, Lianhai Tai, Chong Li, Peng Wu","doi":"10.1038/s41598-025-07304-y","DOIUrl":"https://doi.org/10.1038/s41598-025-07304-y","url":null,"abstract":"<p><p>To investigate the mechanical properties of concrete-foamed cement composite specimens (C-FCCS), uniaxial compression tests were conducted on composite specimens with varying proportions and strengths of foamed cement. The analysis focused on the peak compressive strength, peak strain, macroscopic failure morphology, and acoustic emission (AE) characteristics of C-FCCS. The experimental results indicate that the peak compressive strength of C-FCCS exhibits a negative correlation with the proportion of foamed cement and a positive correlation with the proportion of concrete. At foamed cement proportions of 10% and 20%, the peak compressive strength of C-FCCS is predominantly governed by concrete, with AE energy concentrated primarily during the initial loading phase and near the peak stress. In contrast, at foamed cement proportions ranging from 30 to 50%, the peak compressive strength is dominated by foamed cement, with AE energy concentrated around the peak stress. The peak strain of C-FCCS shows a trend of initially increasing and then decreasing with the increase in height ratio (Height ratio = Foamed cement height/C-FCCS height). Under different height ratios, the peak strain of C-FCCS is approximately 175.61-558.13% of that of pure concrete specimens. Furthermore, variations in the strength of foamed cement have a minimal impact on the peak compressive strength of C-FCCS but significantly affect the peak strain. The peak compressive strength of C-FCCS is about 77.67-83.87% of that of pure concrete specimens, while the peak strain ranges from 128.46 to 361.38%. Lastly, the macroscopic failure of C-FCCS is primarily characterized by tensile failure, with shear failure commonly observed at the edges and corner interfaces of C-FCCS.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22975"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanism of Naringenin in the treatment of hepatocellular carcinoma based on mRNA sequencing and experimental validation.","authors":"Zheng Zhang, Haoran Wang, Xin Liu, Meng He, Yujia Lin","doi":"10.1038/s41598-025-09013-y","DOIUrl":"https://doi.org/10.1038/s41598-025-09013-y","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) ranks among the top three causes of cancer-related mortality globally and is associated with a relatively low five-year overall survival rate. Naringenin has demonstrated significant inhibitory effects on various neoplasms; however, the mechanisms of action and potential molecular targets of naringenin in the context of HCC remain to be elucidated. Cellular proliferation in cancer cells was quantified using the Cell Counting Kit-8 (CCK-8) assay. Wound healing and transwell tests were employed to evaluate the migratory and invasive capabilities of the cells, respectively. Apoptosis was evaluated using Hoechst staining to visualize nuclear changes and flow cytometry to quantify apoptotic populations. Following mRNA sequencing, we integrated the TCGA database with known naringenin-related targets to identify overlapping genes, which were subsequently subjected to clinical significance analysis. The expression of these genes was confirmed at the protein and mRNA levels using Western blot (WB) and quantitative PCR (qPCR), respectively. In vivo experiments were conducted using an MHCC-97H xenograft model in nude mice, with histopathological examination of tumor sections performed using hematoxylin and eosin (H&E) staining. In vitro, naringenin demonstrated a potent inhibitory effect on the proliferation, invasion, and migration of MHCC-97H and Huh7 cells while exhibiting a pronounced pro-apoptotic impact on both cell lines. mRNA sequencing results revealed significant differential gene expression. Utilizing Venn diagrams, we identified key genes, including IGFBP3, PGF, CA9, AKR1C3, KLK1, and CHRNA7. We implicated signaling pathways such as the\"Wnt signaling pathway\"and\"MAPK signaling pathway\"as potentially critical in naringenin's anti-HCC activity. The clinical significance analysis revealed that CA9 and AKR1C3 were identified as autonomous prognostic variables for hepatocellular carcinoma (HCC), a conclusion supported by molecular docking investigations. The therapeutic promise of naringenin was further supported by its considerable reduction in tumor weight and volume shown in animal trials. This study shows that naringenin may regulate signaling pathways by targeting a series of genes: IGFBP3, PGF, CA9, AKR1C3, KLK1, and CHRNA7, resulting in the inhibition of tumor cell proliferation and metastasis, alongside the promotion of apoptosis.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23109"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}