Scientific Reports最新文献

{"title":"Impact of mobile learning operating room principles and communication skills on nursing college students: a quasi-experimental study.","authors":"Sajjad Ranjbar Kouchaksaraei, AmirHossian Yousefinya, Bagher Khoram, Camellia Torabizadeh, Fatemeh Vizeshfar","doi":"10.1038/s41598-025-13099-9","DOIUrl":"https://doi.org/10.1038/s41598-025-13099-9","url":null,"abstract":"<p><p>Electronic education can serve as a new educational approach that meets some of the educational needs of students and enhances the quality and effectiveness of education in these areas. This study aims to investigate impact of Mobile Learning Operating Room Principles and Communication Skills on Knowledge, Attitudes, Performance, and Communication Skills of Nursing College Students. In this quasi-experimental study, 60 working students attending a college participated in two groups: the intervention group and the control group. The intervention group received operating room principles and communication skills training through a mobile application, while the control group received conventional classroom-based training on the same subjects. The data collection tools and process included a demographic information form, questionnaires to assess knowledge, attitudes towards mobile learning, communication skills, patient interaction, and checklists for operating room principles and nursing skills of the students in the clinical setting. Pre-tests and post-tests were conducted before and after the intervention to compare the participants' levels of knowledge, attitudes, performance, and communication skills. The data were analyzed using SPSS software version 19, and descriptive and inferential statistics were employed. Before the intervention, there was no statistically significant difference between the knowledge, attitudes, performance, and communication skills of the two groups. However, the statistical tests demonstrated the effectiveness of the interventions. After the intervention, a significant and meaningful difference (P < 0.001) was observed between the two groups' knowledge, attitudes, performance, and communication skills. Based on the results of this study, mobile educational software can assist in the learning and education of students. Since medical students experience most of their learning in clinical settings, attention should be given to developing software and applications in the clinical domain. With the ever-expanding use of mobile devices and the widespread accessibility of these communication tools to almost all students, incorporating mobile-based education can lead to improved medical education in clinical settings.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27261"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration.","authors":"Hyungwoo Lee, Hyoik Jang, Jae-Byoung Chae, Hyo Kyung Lee, Chanok Son, Chul-Woo Park, Taejeong Ha, Munjeong Yum, Sungmi Park, Sun Woo Hong, Suk Young Lee, Jungmook Lyu, Semin Lee, Dong Ki Lee, Hyewon Chung","doi":"10.1038/s41598-025-07299-6","DOIUrl":"https://doi.org/10.1038/s41598-025-07299-6","url":null,"abstract":"<p><p>Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes central‑vision loss mainly because macular cones and parafoveal rods degenerate. The neural retina leucine zipper (NRL) directs rod photoreceptor differentiation, and its disruption has been linked to upregulated cone-specific markers in rods. This study investigates the therapeutic potential of a cell-penetrating asymmetric small interfering RNA targeting NRL (cp-asiNRL) to induce rod-to-cone conversion and mitigate retinal degeneration. cp-asiNRL was administered intravitreally to C57BL/6J wild-type (WT), neovascular AMD (nAMD), and RP (Rho^P23H/+) mouse models. Subsequent analyses included cone marker expression levels and electroretinographic evaluations, and single-cell RNA sequencing. Administration of cp-asiNRL suppressed NRL expression, increased cone marker expression, and improved retinal function in both WT and nAMD models. In RP mice, cone marker expression was also elevated, although functional improvements were comparatively modest, likely reflecting the advanced disease stage. Single-cell RNA sequencing revealed a rod-to-cone-like transdifferentiation, suggesting that cp-asiNRL-mediated NRL knockdown partially preserved photoreceptor integrity. cp-asiNRL-mediated NRL silencing shows considerable promise as a therapeutic intervention for retinal degenerative conditions. By promoting rod-to-cone transdifferentiation and supporting photoreceptor survival, this approach may offer a novel strategy for vision preservation.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27176"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction and regulatory expression of Polycomb and NuRD complexes in mouse embryonic stem cell under PKC inhibition.","authors":"Fangfang Wu, Zhihui Liu, Jing Huang, Yuan Gao, Lan Yang, Fuliang Du","doi":"10.1038/s41598-025-12427-3","DOIUrl":"https://doi.org/10.1038/s41598-025-12427-3","url":null,"abstract":"<p><p>Polycomb repressive complexes (PRC) and nucleosome remodeling and deacetylase (NuRD) complex are crucial for regulating the expression of pluripotent and developmental genes and maintaining the characteristics of mouse embryonic stem cells (mESCs). However, the interplay between the Polycomb and NuRD complexes in mESCs, particularly under protein kinase C (PKC) inhibition, remains to be elucidated. We knocked down Polycomb complexes components Ezh2, Ring1b, and Cbx7 via short hairpin RNA interference and observed significant reductions in most NuRD complex components, especially Mbd3, Mta1, Rbbp4, and Rbbp7. Similarly, Ezh2 overexpression increased the levels of these major NuRD complex components. Further, Mbd3 knockdown significantly reduced the expression of PRC1 major components Ring1b, Rybp, and Cbx7 and PRC2 major components Ezh2, Suz12, and Eed, but its overexpression had no significant effect on their levels. These results indicate that PKC inhibition provides a suitable environment for the expression of PRC components. Altogether, our study demonstrates that mESCs exhibit mutual gene regulation of Polycomb and NuRD complexes under PKC inhibition that maintains pluripotency and self-renewal abilities and regulates the plasticity of mESCs to balance between pluripotency and cell fate determination.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27204"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of concrete with human hair using experimental study and artificial neural network via response surface methodology and ANOVA.","authors":"Sadık Alper Yıldızel, Memduh Karalar, Ceyhun Aksoylu, Essam Althaqafi, Alexey N Beskopylny, Sergey A Stel'makh, Evgenii M Shcherban', Osman Ahmed Umiye, Yasin Onuralp Özkılıç","doi":"10.1038/s41598-025-12782-1","DOIUrl":"https://doi.org/10.1038/s41598-025-12782-1","url":null,"abstract":"<p><p>The increasing demand for sustainable construction materials has prompted the investigation of non-biodegradable waste, such as human hair (HH), for concrete reinforcement. This study seeks to evaluate the impact of HH fiber on the fresh, physical, and mechanical characteristics of concrete. HH was incorporated in varying proportions (1-5% by weight of cement), along with modifications in cement content, to ascertain optimal performance conditions. An extensive experimental program was executed, succeeded by the utilization of Artificial Neural Networks (ANN) to formulate predictive models for compressive strength (CS), flexural strength (FS), and splitting tensile strength (STS). Furthermore, Response Surface Methodology (RSM) and Analysis of Variance (ANOVA) were utilized to identify statistically significant factors and optimize the mix design. The findings indicated that the mechanical performance of concrete enhanced with HH inclusion up to 3%, after which a deterioration ensued, presumably due to inadequate dispersion and workability challenges. The ANN models precisely predicted mechanical outcomes, while the RSM-derived models demonstrated strong correlations, with R² values of 0.9434, 0.9365, and 0.9311 for CS, FS, and STS, respectively. ANOVA confirmed the significance of model inputs with p-values below 0.05. Furthermore, SEM, EDX, and XRD analyses validated the integration of HH into the concrete matrix and substantiated the observed mechanical properties. This study confirms the feasibility of HH as a sustainable fiber in concrete, enhancing critical performance metrics when applied at optimal dosages. The amalgamation of ANN, RSM, and ANOVA offers a thorough methodology for optimizing innovative concrete composites and clarifying the mechanisms underlying performance enhancement.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27215"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of trauma history and current psychopathology in predicting preventive health behaviors.","authors":"Sheela Raja, Emily P Rabinowitz, Steve Gonzalez, Megan Lee, Shivali Padmani, Memoona Hasnain","doi":"10.1038/s41598-025-11514-9","DOIUrl":"https://doi.org/10.1038/s41598-025-11514-9","url":null,"abstract":"<p><p>This pilot study explored the relationship between self-reported trauma exposure, psychopathology, and coping strategies and preventive health behaviors (PHBs) and self-rated health (SRH) in a sample of clinic patients in a large, urban health system. Results indicated that trauma exposure explained only a small portion of the variance in PHBs and SRH. Higher trauma exposure was not associated with lower PHB engagement, suggesting that trauma's impact on health behaviors may be more nuanced. Specifically, current self-reported psychopathology, including depression, anxiety, and PTSD, was negatively correlated with PHB engagement, and coping strategies accounted for additional variance in PHBs beyond trauma and psychopathology. SRH was significantly influenced by trauma exposure, especially in the presence of psychological distress, but no significant relationship was found between SRH and coping strategies. These results underscore the importance of screening for current psychopathology and coping strategies in healthcare settings, rather than solely focusing on trauma history. Although trauma informed healthcare interventions may focus on screening for trauma, our results suggest that programs should prioritize mental health screening and coping assessment to better address individuals' health risks and promote resilience. Future research should investigate how various types of trauma may differentially impact patients' health behaviors and coping.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27192"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal freeze-out and collective signatures in [Formula: see text] collisions with a non-extensive statistical study on energy and pseudorapidity systematics.","authors":"Haifa I Alrebdi, Muhammad Ajaz, Murad Badshah, Muhammad Waqas, Norah A M Alsaif, Mohammad Ayaz Ahmad, Jihane Ben Slimane","doi":"10.1038/s41598-025-08380-w","DOIUrl":"https://doi.org/10.1038/s41598-025-08380-w","url":null,"abstract":"<p><p>This paper presents a comprehensive analysis of the double-differential [Formula: see text] distributions of charged particles across twelve pseudorapidity regions ([Formula: see text], bin width [Formula: see text]) in [Formula: see text] collisions at [Formula: see text], 2.36, and 7 TeV. Using a modified Tsallis function incorporating an effective transverse flow velocity, we achieve excellent agreement between the model and experimental data, with consistent fit quality across all [Formula: see text] ranges (validated by Data/Fit panels). The extracted parameters including kinetic freeze-out temperature ([Formula: see text]), mean transverse flow velocity ([Formula: see text]), non-extensivity parameter ([Formula: see text]), and mean transverse momentum ([Formula: see text]) reveal systematic dependencies on η and [Formula: see text]. Both [Formula: see text], [Formula: see text], and [Formula: see text] decrease with [Formula: see text], attributed to reduced energy deposition and weaker thermalization in fragmentation-dominated high-[Formula: see text] regions. These parameters also exhibit marked growth with [Formula: see text], reflecting collision-energy-driven dynamics. In contrast, [Formula: see text] increases with [Formula: see text], signaling greater deviation from thermal equilibrium (Boltzmann limit [Formula: see text]) at larger [Formula: see text], while mid-η particles ([Formula: see text]) approach near-equilibrium behavior. Parameter correlations, particularly between [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text], highlight interplay between thermal and collective-like dynamics. The results provide critical insights into the interplay of thermalization, effective flow, and non-equilibrium effects in small collision systems, advancing the understanding of bulk hadronic matter in high-energy [Formula: see text] interactions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27194"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threshold effect study on the development of prefabricated buildings for energy conservation and emission reduction in the construction industry.","authors":"Yuan Qi, Xinyi He, Yuanbin Li, Yufei Jia","doi":"10.1038/s41598-025-12811-z","DOIUrl":"https://doi.org/10.1038/s41598-025-12811-z","url":null,"abstract":"<p><p>Prefabricated construction is a key strategy for achieving a low-carbon transformation in the construction sector. In the context of national policies and standards aimed at promoting an increase in the prefabrication rate, recent investigations have revealed that the environmental benefits of prefabricated construction cannot be consistently realized, and the lack of data on the development of prefabricated construction has resulted in limited related research. To address this issue, this paper tackles the issue of inadequate data on indicators pertaining to the growth of prefabricated construction by utilizing crawler technology. It employs the super-efficiency slack-based measure (SBM) model to assess the comprehensive energy-saving and emission-reduction efficiency of China's construction industry. Using the Technology-Organization-Environment (TOE) framework and threshold regression models construct an impact mechanism model to study the main driving factors of energy conservation and emission reduction (ECER) in the construction industry, with a particular focus on the development of prefabricated construction and its associated threshold effects. The results indicate that: (1) China's construction industry's ECER efficiency shows a fluctuating growth trend, with the national average efficiency ranging between 0.6 and 0.8, and significant regional disparities. (2) At this stage, the prefabrication rate, policy effectiveness, and the number of patent applications are key factors affecting the ECER efficiency of the construction industry, with the prefabrication rate and policy effectiveness exhibiting a double-threshold effect. (3) The optimum ECER outcomes are obtained by keeping the prefabrication rate between 50% and 60%, and the effectiveness of policies in fostering these goals is trending downward. Therefore, controlling the rate at which new buildings are prefabricated, comprehending the efficacy of policy standards, and raising the technological level of prefabricated construction are all practical ways to increase the construction industry's efficiency in reducing emissions and conserving energy. This study offers a theoretical foundation and decision-making basis for relevant authorities in formulating measures and quantifying indicators, contributing to the development of prefabricated construction and enhancing ECER efficiency in the construction industry.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27269"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism exploration of di(2-ethylhexyl) phthalate (DEHP)-induced breast cancer via network toxicology and molecular docking analysis.","authors":"Zhongcheng Wang, Yunwen Wang","doi":"10.1038/s41598-025-13201-1","DOIUrl":"https://doi.org/10.1038/s41598-025-13201-1","url":null,"abstract":"<p><p>Disease caused by plasticizers has received increasing attention. Di(2-ethylhexyl) phthalate (DEHP), one of the most widely exposed plasticizers, has been shown to be closely associated with the development of breast cancer (BRCA) in epidemiological studies, but the specific mechanistic targets and related pathways are still unclear. In this study, we aimed to elucidate the potential pathogenic targets and mechanisms of DEHP-induced BRCA through network toxicology and molecular docking. Databases including GeneCards, OMIM, ChEMBL, and SwissTargetPrediction were first used to identify DEHP-related targets and BRCA-related targets, and 691 potential targets were obtained from the intersection analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to clarify the biological functions and pathways of potential targets. Protein-protein interaction (PPI) analysis revealed the interactions between potential targets, and 14 hub targets of DEHP-induced BRCA were further screened. To verify the clinical significance of the hub targets, the expression of the target proteins was verified in the TCGA database, and the affinity between DEHP and 12 key targets (hub targets with p < 0.05) was determined via molecular docking. Our study provides a theoretical basis for DEHP-induced BRCA from the \"Homo sapiens\" perspective and reveals the potential risks caused by exposure to DEHP, thus providing new strategies for the prevention and treatment of DEHP-induced BRCA.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27257"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial diversity and metabolic predictions of high-temperature streamer biofilms using metagenome-assembled genomes.","authors":"Jia Hao Tan, Kok Jun Liew, Rajesh K Sani, Dipayan Samanta, Stephen B Pointing, Kok-Gan Chan, Kian Mau Goh","doi":"10.1038/s41598-025-12132-1","DOIUrl":"https://doi.org/10.1038/s41598-025-12132-1","url":null,"abstract":"<p><p>High-temperature streamer biofilm communities (SBCs) are often dominated by Aquificota, which can comprise over 90% of the microbial population in shallow water channels, such as those found at Mammoth hot springs of Yellowstone National Park and the Rehai hot springs in China. This study examines SBCs from the Dusun Tua (DT) hot spring in Malaysia (75 °C, pH 7.6), where Aquificota accounted for only ~ 35% of the total amplicon sequence variants. Amplicon and hybrid metagenomic sequencing revealed a more balanced microbial community, co-dominated by Aquificota, Chloroflexota, Desulfobacterota, Bacteroidota, Deinococcota, and Candidatus Hydrothermae, along with Thermoproteota and Micrarchaeota. To our knowledge, the co-dominance of Aquificota and Chloroflexota in SBCs has not been previously reported. The unexpected abundance of Chloroflexota may stem from dispersal from upstream Cyanobacteriota-Chloroflexota biofilms, contributing to community diversification. Genome-resolved analyses identified more than 60 medium- to high-quality metagenome-assembled genomes (MAGs), suggesting that biofilm formation was initially driven by chemoautotrophic sulfur oxidation and CO₂ fixation, followed by the gradual integration of heterotrophic taxa. Nitrogen cycling and hydrogen oxidation are likely to contribute additional sources of energy. The presence of diverse CAZymes suggests that plant litter may serve as an additional carbon source. Genome-centric analyses across multiple phyla indicated that extracellular polymeric substances (EPS), curli fibers, and other matrix components contribute to the biofilm matrix, enhancing structural resilience and supporting persistence under harsh conditions. Overall, this study highlights the distinct microbial ecology of the DT SBC and broader metabolic roles beyond Aquificota dominance. The genes identified in this study may hold biotechnological potential and serve as a valuable resource for future enzyme discovery and functional screening.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27297"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling cross-diffusion in MHD Williamson nanofluid flow over a nonlinear stretching surface via Morlet wavelet neural networks.","authors":"Khalid Arif, Syed Tauseef Saeed, Muhammad Naeem Aslam, Jihad Younis, Arshad Riaz, Salman Saleem","doi":"10.1038/s41598-025-06912-y","DOIUrl":"https://doi.org/10.1038/s41598-025-06912-y","url":null,"abstract":"<p><p>In this paper, a new numerical technique was developed to investigate magnetohydrodynamic (MHD) flow of Williamson nanofluid past a nonlinear stretching surface imbedded in a porous medium laden with Soret and Dufour effects. The control equations, which are highly nonlinear partial differential equations, are first converted into ordinary differential equation (ODEs) using similarity transformation and then are solved effectively by the hybrid computational method applying Morlet Wavelet Neural Networks (MWNNs) combined with a heuristic optimizers neural network and particle swarm as MWNNs-PSO-NNA. The proposed MWNNs-PSO-NNA shows a very low mean square error and Theil's Inequality Coefficient indicating that the accuracy of the model. To check the convergence and validation of the proposed approach, computing the hundred independent runs for statistical metrics. The fitness function, MSE and TIC values ranging from 10^-07 to 10^-05, 10^-09 to 10^-07 and 10^-06 to 10^-04 respectively. It is found that increasing the effects of the Williamson number, magnetic parameter, porosity and stretching index inhibit the velocity field while Brownian motion as well as the Williamson number enhances the temperature profile. The concentration rises with Soret and Brownian motion parameters but diminishes with intensified thermophoresis and magnetic influences. These findings confirm that the proposed hybrid model is not only computationally robust but also highly effective for solving complex fluid flow problems in engineering and applied sciences.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27287"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}