Scientific Reports最新文献

{"title":"An interpretable framework for risk management in TBM excavation using expert elicitation integrated with fuzzy set theory.","authors":"Kibeom Kwon, Minkyu Kang, Young Jin Shin, Byoungcheol Ahn, Hangseok Choi","doi":"10.1038/s41598-025-07514-4","DOIUrl":"https://doi.org/10.1038/s41598-025-07514-4","url":null,"abstract":"<p><p>Risk management is essential for optimal decision-making during tunnel boring machine (TBM) excavation. Previous methods, however, have struggled with interpreting the uncertainties associated with TBM excavation and managing multiple concurrent adverse factors. This study proposes an interpretable risk management method that effectively addresses these uncertainties and concurrent sources. It employs an expert elicitation framework combined with fuzzy set theory to distribute the confidence levels of experts' evaluations across multiple classes. The resulting impact, probability, and risk are presented as distributions, allowing for a comprehensive interpretation of expert judgment trends, which reveals how uncertainties are distributed and identifies any dominant class or risk level. The proposed method was applied to a slurry shield TBM tunnel project, where most distributions showed no single dominant class or risk level due to significant uncertainties, emphasizing the need for comprehensive interpretation. Furthermore, the method effectively addressed increased probabilities and risks stemming from concurrent factors, in contrast to when these factors were considered individually. Comparative analysis demonstrated that even meaningful but minor responses can significantly influence the determination of risk levels through comprehensive interpretation.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23030"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose index and thyroid nodule: a cross-sectional study in Western Liaoning Province, China.","authors":"He Xu, Chang Si","doi":"10.1038/s41598-025-07822-9","DOIUrl":"https://doi.org/10.1038/s41598-025-07822-9","url":null,"abstract":"<p><p>The aim of this study was to investigate the prevalence of thyroid nodule and its association with triglyceride-glucose index (TyG) in Western Liaoning Province of China. A cross-sectional survey was conducted in six counties under the jurisdiction of Huludao, Fuxin, and Chaoyang in Liaoning Province from 2019 to 2022. All the subjects who underwent thyroid B-ultrasound and related biochemical tests were recruited. TyG was calculated using fasting triglycerides and plasma glucose. A total of 2374 subjects were included, of which 583 (24.6%) were found to have thyroid nodules. The results of multivariate regression analysis indicated that a higher quartile of TyG was an independent risk factor for thyroid nodule. The results of subgroup analysis suggested that the above association was more explicit in younger subjects, non-smokers, highly educated or high-income groups, and non-iodine-deficient subjects. Similar findings were demonstrated in subjects with solitary or multiple thyroid nodules. Our study suggested for the first time that a higher TyG level is the risk factor for thyroid nodule, and the association between the two is more explicit in specific populations. It is recommended that people with high TyG levels should pay more attention to the regular screening of TN.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23100"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study.","authors":"Julien De Greef, Khoi Nguyen Nguyen, Matthias Van Hul, Anthony Puel, Jean Cyr Yombi, Bernard Vandercam, Anne Vincent, Laure Elens, Leïla Belkhir, Vincent Haufroid, Patrice D Cani","doi":"10.1038/s41598-025-06500-0","DOIUrl":"https://doi.org/10.1038/s41598-025-06500-0","url":null,"abstract":"<p><p>Dolutegravir and bictegravir are second-generation HIV integrase strand transfer inhibitors (INSTIs) that were previously associated with abnormal weight gain. This monocentric cross-sectional study investigates associations between weight gain during the first year after initiation of dolutegravir, bictegravir or other anchor drugs and gut microbiome diversity as well as taxa composition. The study enrolled 79 participants receiving dolutegravir, 32 receiving bictegravir and 10 receiving non-INSTI based regimens. Most of them were treatment experienced at initiation of those anchor drugs agents. Although weight gain was not linked to overall bacterial diversity, strong associations with specific taxa were demonstrated (FDR q < 0.01). Using multiple linear regression, we identified 4 distinct groups of bacteria associated with either dolutegravir, bictegravir, weight loss or weight gain under treatment, allowing a machine learning model to predict 15.9% of the weight gain variability regardless of sex, age and body mass index (RMSE: 0.0126). Dysosmobacter sp. and Haemophilus sp., two bacteria previously associated with host metabolism, were among the strongest predictors. Our findings link INSTIs, weight gain, and the gut microbiome. Future research should investigate the causal role of the identified taxa to improve our understanding of microbiome-drug interactions and further support personalized antiretroviral strategies.Trial registration: Eudra-CT 2020-001103-17 (registration date: 2020-12-01).</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22603"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between bipolar disorder and diabetic ketoacidosis/hyperosmolar hyperglycemic state.","authors":"Han-Jung Liu, Shih-Chang Lo, Chien-Ning Huang, Yi-Sun Yang, Yu-Hsun Wang, Edy Kornelius","doi":"10.1038/s41598-025-08087-y","DOIUrl":"https://doi.org/10.1038/s41598-025-08087-y","url":null,"abstract":"<p><p>Individuals with bipolar disorder have a higher prevalence of type 2 diabetes mellitus (T2DM) and are at increased risk for diabetes-related complications. However, little is known about the association between bipolar disorder and acute hyperglycemic crises, including diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). This study aimed to evaluate whether bipolar disorder is associated with an increased risk of DKA and HHS in individuals with newly diagnosed T2DM. We conducted a retrospective cohort study using the TriNetX electronic health records network. Adults diagnosed with T2DM between 2016 and 2024 who received at least one glucose-lowering medication were included. Patients with a recorded diagnosis of bipolar disorder within one year before T2DM onset formed the exposure group, while those without bipolar disorder served as controls. Individuals with pre-existing hyperglycemic crises were excluded. Propensity score matching (1:1) was applied to balance demographic factors, body mass index, comorbidities, and medication use. The primary outcome was the incidence of DKA or HHS, analyzed using Cox proportional hazards models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). After matching (N = 39,676 per group), patients with bipolar disorder had a significantly higher risk of hyperglycemic crises (HR 1.65, 95% CI 1.45-1.88). Separate analyses revealed an increased risk of DKA (HR 1.58, 95% CI 1.37-1.82) and HHS (HR 1.95, 95% CI 1.30-2.94). Subgroup analyses suggested that the association was more pronounced in younger patients, White individuals, those with cerebrovascular disease, and those on insulin therapy. Bipolar disorder may be associated with a higher risk of acute hyperglycemic crises in patients with newly diagnosed T2DM. These findings highlight the need for integrated psychiatric and diabetes care to mitigate metabolic decompensation. Future prospective studies are warranted to further explore the mechanisms underlying this association and to develop targeted interventions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22701"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the content and accumulation of macroelements in different parts of the quinoa plant biomass Chenopodium quinoa willd.","authors":"Józef Sowiński, Aleksandra Franz, Joanna Nowak","doi":"10.1038/s41598-025-04797-5","DOIUrl":"https://doi.org/10.1038/s41598-025-04797-5","url":null,"abstract":"<p><p>The aim of the research was to determine the effect of harvest date on the content and accumulation of macroelements in quinoa cultivated for seeds. Chemical analyses of macroelement content were conducted on plant material collected during a field experiment at the Swojczyce Station in 2021 (Poland). Due to similar unfavorable weather conditions during the harvests period of 2021-2022, biomass from a single year only was used for analyses. The biomass was categorized into seeds, infructescence remnants, and stems. Quinoa plant biomass were collected at six 7-days intervals between August 18 and September 21. In the study assessed three quinoa varieties: Zeno, Titicaca, and Vikinga. For each varieties and harvest time, the concentrations of nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg), and (calcium) Ca were determined. Macroelement uptake was calculated in mg per plant. The quinoa exhibited the highest N accumulation in the seeds, and the highest K accumulation in the infructescence remnants and stems. The Titicaca variety demonstrated the greatest uptake of N (over 600 mg), P (80 mg), K (980 mg), and Ca (160 mg) per plant. Magnesium accumulation was most pronounced in the Titicaca and Vikinga varieties (100 mg per plant of each). Plant biomass (r = 0.899) and infructescence remnants N uptake (r = 0.803) was highly correlated with total macroelements uptake. The result of this study should be taken into account when determining quinoa value as a forecrop.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22918"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic mode analysis of electromagnetic interference susceptibility in motor driven unmanned drones for enhanced design and performance.","authors":"Peyman Hasani, Seyed Mohamad Hashemi, Alireza Sadeqi, Javad Ghalibafan, Valiollah Mashayekhi","doi":"10.1038/s41598-025-05835-y","DOIUrl":"https://doi.org/10.1038/s41598-025-05835-y","url":null,"abstract":"<p><p>The rapid advancement of portable device technology, especially in the realms of drones and motor-driven systems, underscores the critical need for thorough analysis of Electromagnetic Interference (EMI) to guarantee operational reliability and safety. These systems' vulnerability to EMI can result in diminished performance and heightened safety concerns, making it essential to evaluate their susceptibility. This research explores how brushless and brushed motors respond to EMI through Characteristic Mode Analysis (CMA), pinpointing significant frequency modes-2.1 GHz, 2.92 GHz, and 2.98 GHz-that impact motor functionality differently, with Mode 1 at 2.1 GHz being the most significant. Due to constraints in testing capabilities, the study focused on radiation exposure at 2.45 GHz. Experiments conducted with a 22 kW electromagnetic source revealed that as the motor neared the source, disruptions increased, culminating in total motor failure at a distance of 0.6 m. Additionally, the extensive wiring connected to the motor intensified damage by inducing extra currents, thereby amplifying the motor's susceptibility beyond that of direct radiation exposure. The results of this study demonstrate the effectiveness of CMA in forecasting EMI effects and offer critical insights into the vulnerabilities present in motor-driven systems. By identifying the relevant radiation frequency, pattern, and power density that contribute to component damage, proactive measures can be taken to shield electronic components from adverse environmental conditions characterized by these factors.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22801"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, and anti-urease evaluations of new sulfonamide-1,2,3-triazole-acetamide derivatives.","authors":"Shohreh Bakhshi Varzaneh, Amir Shervin Shokouhi Asl, Mohammad Hosein Sayahi, Amir Mohammad Taherkhani, Meysam Talebi, Navid Dastyafteh, Sajedeh Safapoor, Mehdi Emadi, Majid Alikhani, Rozita Yazzaf, Mohammad Halimi, Massoud Amanlou, Bagher Larijani, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi","doi":"10.1038/s41598-025-07553-x","DOIUrl":"https://doi.org/10.1038/s41598-025-07553-x","url":null,"abstract":"<p><p>The present study demonstrated the design and synthesis of sulfonamide-1,2,3-triazole-acetamide derivatives 11a-o and screening against urease in vitro and in silico. These compounds were designed based on reported potent urease inhibitors and optimized structurally based on substituents on acetamide moiety. In vitro studies showed that all the new compounds 11a-o (IC₅₀ values = 0.12-4.53 µM) were more potent than stand inhibitor thiourea (IC₅₀ value = 23.76 µM). In this regard, the most potent compounds were N-phenylacetamide derivatives 11b, 11f, and 11 h with 2-methyl, 4-methoxy, and 2-fluoro substituents, respectively. In this regard, the most potent compound 11b was 198-folds more potent than thiourea against urease. In silico studies demonstrated that this compound with the binding energy less than thiourea attached to the urease's active site. Druglikeness, pharmacokinetics, and toxicity of compound 11b and thiourea were predicted by two credible online servers. These in silico studies showed that, in terms of druglikeness and pharmacokinetics, compound 11b was almost similar to thiourea while in term of toxicity, compound 11b was better than thiourea.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22565"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of fasting blood sugar using a microwave sensor and convolutional neural network.","authors":"Mohammad Amir Sattari, Mohsen Hayati","doi":"10.1038/s41598-025-06502-y","DOIUrl":"https://doi.org/10.1038/s41598-025-06502-y","url":null,"abstract":"<p><p>Monitoring of fasting blood sugar (FBS) is a critical component in the diagnosis and management of diabetes, one of the most widespread chronic diseases globally. Microwave sensing-particularly through microstrip-based sensors-has recently gained attention as a promising technique for blood glucose monitoring, offering advantages such as low cost, high sensitivity, real-time response capability, and suitability for compact and wearable systems. In this study, a miniaturized microstrip microwave sensor is presented for non-contact FBS detection. Blood samples were directly collected from 78 individuals and analyzed using a clinical-grade auto-chemistry analyzer to determine reference FBS levels. Each sample was measured five times on the microwave sensor, resulting in a total of 390 transmission responses (S21) across a frequency range of 30 kHz to 18 GHz. These responses were recorded under controlled laboratory conditions, ensuring consistency and minimizing environmental interference. To interpret the complex, non-linear features of the sensor response, a convolutional neural network (CNN) was developed and trained using the entire dataset. The network demonstrated highly promising performance in estimating FBS values, achieving a mean relative error (MRE) of 1.31%. The results confirm the feasibility of combining broadband microwave sensing with deep learning techniques to enable reliable non-contact blood glucose measurement. This approach holds strong potential for integration into future wearable health monitoring systems, providing more user-friendly diabetic management tools without the frequent use of conventional blood sampling techniques.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22937"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deletion of PTHrP nuclear localization sequence and carboxyl terminus leads to lung dysplasia.","authors":"Youyu Li, Yaoyao Jin, Jiawen Zhou, Min Cui, Chenyu Xiao, Yongjie Zhang","doi":"10.1038/s41598-025-08163-3","DOIUrl":"https://doi.org/10.1038/s41598-025-08163-3","url":null,"abstract":"<p><p>Parathyroid hormone-related peptide (PTHrP) is a factor that plays an important role in the growth and development of multiple organs. The role of PTHrP in lung development has not been characterized. In order to further investigate the in vivo functions of PTHrP nuclear localization sequence (NLS) and C-terminus, Professor Andrew Karaplis and Professor Dengshun Miao et al. used genetic engineering technology to knock in (KI) a stop codon (TGA) after the 84th amino acid sequence of PTHrP and constructed a mouse model expressing only PTHrP (1-84), but not NLS and C-terminus, namely PTHrP NLS and C-terminal knockout mice (also PTHrP KI mice). Using this genetically modified mouse model, we have characterized its effect on early postnatal lung development. Compared with those in littermate wild-type (WT) mice, the body size and lung volume were significantly reduced and the lung weight index was significantly increased in PTHrP KI mice. Histologically, deletion of the NLS and C-terminus of PTHrP could reduce lung cell proliferation, facilitate cell apoptosis, increase the expression of inflammatory factors, cause increased oxidative stress and DNA damage, and lead to lung dysplasia. Meanwhile, deletion of the NLS and C-terminus of PTHrP could also induce pulmonary fibrosis by activating the TGF-β/Smad signaling pathway. We conclude that PTHrP NLS and C-terminus play important roles in lung development.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22966"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the implementation of HIV/AIDS prevention and treatment policies on the mortality rate of people living with HIV in Guilin, China.","authors":"Yan Feng, Ying Zhuo, Jie Tang, Guodong Zhang, Wuxiang Shi, Lingmi Zhou","doi":"10.1038/s41598-025-07683-2","DOIUrl":"https://doi.org/10.1038/s41598-025-07683-2","url":null,"abstract":"<p><p>To analyze the changing trend of HIV/AIDS-related mortality before and after the implementation of the \"Prevention and Treatment of HIV/AIDS\" policy in Guilin from 1996 to 2020, and to evaluate its effect on HIV/AIDS prevention and treatment. The data of people with HIV reported in Guilin up to December 31, 2020, were obtained from the Chinese Center for Disease Control and Prevention (CDC), and the two rounds of \"Prevention and Treatment of HIV/AIDS\" policy intervention boundary points were taken in 2010 and 2015, respectively. The interruption time series (ITS) analysis was used to analyze the trend of HIV/AIDS-related mortality before and after the implementation of the HIV/AIDS Prevention and Treatment Project. From 1996 to 2020, the HIV/AIDS mortality rate decreased in Guilin, and the HIV/AIDS mortality rate of farmers was higher than the overall HIV/AIDS mortality rate. The ITS method analysis results showed that after the implementation of two rounds of \"Prevention and Treatment of HIV/AIDS\" policy, HIV/AIDS mortality rate showed a downward trend. Between 2010 and 2015, the overall decline in HIV/AIDS mortality rate exhibited a slope of -2.217 (P < 0.01). For individuals with an education level of high school or below, the decline in HIV/AIDS mortality rate during this period had a slope of -2.110 (P < 0.01). Among the farmer population, the decline in HIV/AIDS mortality rate from 2010 to 2015 was even more significant, with a slope of -2.510 (P < 0.01). From 2015 to 2020, the overall HIV/AIDS mortality rate continued to decline, showing a slope of -0.230 (P < 0.01). Between 2015 and 2020, for those with an education level of high school or below, the decline in HIV/AIDS mortality rate had a slope of -0.225 (P < 0.01). In contrast, the decline in HIV/AIDS mortality rate among farmers from 2015 to 2020 was steeper, with a slope of -0.319 (P < 0.01). From 2010 to 2020, the HIV/AIDS mortality rate in Guilin has shown a decreasing trend, indicating that the implementation of the \"Prevention and Treatment of HIV/AIDS\" policy has achieved good results.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"22629"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144543084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}