Scientific Reports最新文献

{"title":"IL-36 activates neutrophil extracellular traps and exacerbates LPS-induced ARDS in mice.","authors":"Haiyan Hu, Lifen Wang, Fu Jin, Shengqin Li","doi":"10.1038/s41598-026-51329-w","DOIUrl":"https://doi.org/10.1038/s41598-026-51329-w","url":null,"abstract":"<p><p>Sepsis-induced acute respiratory distress syndrome (ARDS) is characterized by uncontrolled pulmonary inflammation and neutrophil-driven pathology. Neutrophil extracellular traps (NETs) have been implicated in ARDS progression, but the role of interleukin-36 (IL-36) in this process remains unclear. This study aimed to investigate the regulatory mechanism of IL-36 via NETs and its impact on NF-κB activation in a murine model of LPS-induced ARDS. A lipopolysaccharide (LPS)-induced ARDS model was established in C57BL/6 mice. Animals were divided into Control, ARDS, ARDS + IL-36, and ARDS + IL-36Ra groups. Pulmonary edema was assessed via wet/dry weight ratio, inflammatory cytokines were measured by ELISA, and histopathological changes were evaluated through H&E staining. NETs formation was analyzed using immunofluorescence and Western blot. NF-κB activation was detected via phosphorylation of p65. IL-36 administration exacerbated pulmonary edema, inflammatory cytokine levels (IL-10,TNF-α,MPO) and histopathological injury. Conversely, IL-36 receptor antagonist (IL-36Ra) attenuated these effects. IL-36 promoted NETs formation, as indicated by elevated citrullinated histone H3 (CitH3) and neutrophil elastase (NE) expression. NETs further enhanced IL-36-induced proinflammatory cytokine release and NF-κB activation in bronchial epithelial cells. IL-36Ra partially reversed NET-mediated NF-κB phosphorylation and inflammatory responses. IL-36 exacerbates LPS-induced ARDS by enhancing NETs formation and activating the NF-κB pathway, leading to amplified pulmonary inflammation and injury. Targeting IL-36 signaling may represent a potential therapeutic strategy to mitigate LPS-induced ARDS progression.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of greenhouse gas emissions from Bonga and Menz sheep breeds managed under community-based breeding program.","authors":"Assemu Tesfa, Mengistie Taye, Aynalem Haile, Zerihun Nigussie, Dina Najjar, Shigdaf Mekuriaw, Shimels E Wassie, Shanbel Besufkad, Zelalem Abate, Checkol Demis, Tesfaye Getachew, Suzanne van Dijk, Andreas Wilkes, Dawit Solomon","doi":"10.1038/s41598-026-39912-7","DOIUrl":"https://doi.org/10.1038/s41598-026-39912-7","url":null,"abstract":"<p><p>Livestock systems contribute substantially to Greenhouse Gas (GHG) emissions, highlighting the need for interventions that enhance productivity while lowering environmental impact. This study assessed GHG emissions and emission intensity (EI) in Ethiopian Menz and Bonga sheep managed under Community-Based Breeding Programs (CBBP) compared with non-CBBP flocks. Using FAO's GLEAM-i model with long-term performance data (2009-2022) and surveys of 321 households, we found that CBBPs reduced total emissions by 14.56% in Menz and 7.04% in Bonga sheep, while protein output rose by 42% and 2%, respectively. EI declined by 21.49% in Menz and 6.29% in Bonga. At the household level, CBBP flocks achieved markedly lower EI, 39.39% in Menz and 30.68% in Bonga, despite higher absolute emissions from larger flocks. Methane, mainly from enteric fermentation, accounted for a higher proportion compared to other GHG gases. EI was positively associated with reproductive inefficiencies while negatively associated with growth traits, underscoring key levers for mitigation. These results demonstrate that CBBPs deliver both productivity gains and environmental co-benefits, offering a scalable model for climate-smart small ruminant development with relevance beyond Ethiopia.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac-specific mortality prediction in adolescents and young adults with classical hodgkin lymphoma: a nomogram development and validation.","authors":"Rui Yan, Jiaying Niu, Weijia Zhang, Yufeng Zhang, Jinglian Li, Sijin Li","doi":"10.1038/s41598-026-51913-0","DOIUrl":"https://doi.org/10.1038/s41598-026-51913-0","url":null,"abstract":"<p><p>As survival for classical Hodgkin lymphoma (cHL) improves, cardiac disease is a leading cause of non-relapse mortality, yet the risk of cardiac-specific mortality (CSM) in adolescents and young adults (AYAs) is unclear. This study developed and validated a nomogram to predict CSM for AYAs with cHL using data from the SEER database, with a training cohort of 7,475 patients for model development and a validation cohort of 3,205 patients for internal validation. A Fine-Gray competing risk model was used, with the cumulative incidence of CSM surpassing that of cHL over time. Analysis identified Black race, male sex, older age, earlier diagnosis year, and radiotherapy as significant risk factors for CSM. The resulting nomogram estimates the 15- and 25-year risks of CSM using age, race, sex, diagnosis year, Ann Arbor stage, and radiotherapy. Validation demonstrated strong discriminatory ability via ROC curves, with calibration plots and decision curve analysis confirming its accuracy and clinical utility. This nomogram is a useful tool for predicting CSM in the AYA population and may aid physicians in managing clinical risk factors.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creep characteristics and poromechanics-based viscoelastic-plastic constitutive model of warm and ice-rich frozen sand.","authors":"Fulong Ma, Jian Li, Chunhui He, Enlong Liu, Haoran Zhou, Wei Jin, Yihui Zhong, Gang Wu","doi":"10.1038/s41598-026-48328-2","DOIUrl":"https://doi.org/10.1038/s41598-026-48328-2","url":null,"abstract":"<p><p>Motivated by the pronounced rheological behavior of warm and ice-rich frozen soils, we developed a specimen preparation method tailored to ice-rich materials. We conducted a series of triaxial creep tests on saturated frozen sand with 20% ice content and on ice-rich frozen sand with 67% ice content; comparative analyses revealed distinct differences in their creep responses. Building on poromechanics and a binary-medium framework, we propose a viscoelastic-plastic constitutive model for warm frozen soils that accounts for interactions among the soil skeleton, ice, and unfrozen water, as well as the progressive breakage of ice-cement bonds. Validation against experimental data demonstrates that the model accurately captures the creep behavior of warm frozen soils across a range of ice contents and stress levels.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioprotective potential of Ophioparma ventosa (L.) Norman extract against UV-C-induced damage in Allium cepa.","authors":"Oksal Macar, Tuğçe Kalefetoğlu Macar, Kadir Kınalıoğlu, Kültiğin Çavuşoğlu, Emine Yalçın","doi":"10.1038/s41598-026-52683-5","DOIUrl":"https://doi.org/10.1038/s41598-026-52683-5","url":null,"abstract":"<p><p>Ultraviolet-C (UV-C) radiation is capable of inducing severe physiological, cytogenetic, and biochemical disturbances in living organisms. Increasing exposure to artificial UV-C sources has intensified the search for natural radioprotective agents. Thanks to their unique antioxidant compounds and natural UV-filtering metabolites, lichens are able to withstand high levels of ultraviolet radiation. This study evaluated the protective potential of Ophioparma ventosa (L.) Norman lichen extract against adverse effects of UV-C in Allium cepa L., a well-established bioindicator for genotoxicity and oxidative stress assessment. Onion bulbs were exposed to 254-nm UV-C radiation alone or in combination with two concentrations of aqueous extract of O. ventosa (0.5 g/L and 1.0 g/L) for 72 h. Physiological parameters including germination percentage, root elongation, and weight gain were assessed. Genotoxic effects were evaluated using mitotic index (MI), micronucleus (MN) frequency, chromosomal aberrations (CAs), and DNA fragmentation (Comet assay). Malondialdehyde (MDA), proline levels, superoxide dismutase (SOD) and catalase (CAT) activities, and chlorophyll a and b contents were determined as oxidative stress markers. In addition, meristematic cell integrity was examined microscopically, and phenolic constituents of the extract were characterized by LC-MS/MS. UV-C exposure suppressed root growth, reduced MI, increased MN and CAs frequencies, elevated DNA fragmentation, and enhanced oxidative stress biomarkers, confirming its strong cytotoxic and genotoxic potential. Applied doses of the O. ventosa extract alone did not induce toxicity on A. cepa. In contrast, co-application of O. ventosa extract significantly mitigated these adverse effects in a dose-dependent manner. LC-MS/MS analysis revealed the presence of phenolic compounds, including p-coumaric acid, gallic acid, vanillin, gentisic acid and taxifolin, which likely contribute to the observed antioxidant and protective effects. Findings of the present study demonstrate that O. ventosa possesses radioprotective capacity against UV-C toxicity and highlight its potential as a natural bioresource for mitigating radiation-related oxidative and genotoxic stress in plant systems.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility study on using a detection dog to localize hibernacula of Vipera berus.","authors":"Madita Schemel, Sascha Buchholz, Jelena Mausbach","doi":"10.1038/s41598-026-51778-3","DOIUrl":"https://doi.org/10.1038/s41598-026-51778-3","url":null,"abstract":"<p><p>The European adder (Vipera berus), classified as critically endangered in Germany, faces severe threats from habitat loss, particularly the decline of primary habitats such as peatlands. Peatland restoration is essential but may pose risks when hibernacula are not considered during rewetting, potentially leading to flooding, site loss, and population declines. Similar risks arise from construction activities in secondary habitats. Protecting these key sites is therefore vital for species conservation but requires reliable methods to locate them. Traditional monitoring approaches, such as visual surveys and telemetry, are often invasive, imprecise, or resource-intensive. This study tested whether a trained adder detection dog could identify adder scent-using sheds and fecal swabs-beneath substrate in controlled line-up experiments and under field conditions. In the line-up tests, we assessed how sample type, burial depth, and substrate influenced detection performance, whereas field searches evaluated detection success under more realistic conditions. In a pilot study, we further examined whether the dog could generalize from collected odor samples to live adders by testing its ability to locate the hibernacula of two previously tagged individuals. In the line-up experiments, the dog identified both sheds and fecal swabs with high sensitivity, performing slightly better with sheds. Detection remained effective at depths of up to 1.2 m, although detection success declined with increasing depth. Under field conditions, the dog reliably detected samples buried at a depth of 50 cm without any false indications. In the pilot study, the dog successfully located hibernating adders, demonstrating that training non-invasively with collected odor samples rather than live animals can be sufficient for this purpose. These findings suggest that detection dogs represent a promising, non-invasive, and efficient tool for locating adder hibernacula. Future studies should include multiple dogs, larger sample sizes, and additional tagged individuals to further validate detection performance under field conditions.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"16 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent association between relative fat mass and total bone mineral density in U.S. adolescents: a cross-sectional study adjusting for Appendicular Lean Mass Index.","authors":"Penghui Lv, Chenglong Zhang, Shuaiwei Wei, Jincheng Bai, Lu Li, Jianjun Chang","doi":"10.1038/s41598-026-52209-z","DOIUrl":"https://doi.org/10.1038/s41598-026-52209-z","url":null,"abstract":"<p><p>The relationship between adiposity and bone health, often referred to as the \"obesity paradox,\" remains a subject of debate. Relative fat mass (RFM) has recently emerged as a more accurate surrogate for body fat percentage than the Body Mass Index (BMI). However, the independent association between RFM and bone mineral density (BMD) in the adolescent population, particularly after rigorously accounting for lean mass, remains ambiguous, particularly concerning the independent metabolic influence of adiposity. This cross-sectional study evaluated 3,933 adolescents (aged 12-19 years) from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Multiple imputation was applied to manage missing covariates. We employed weighted multivariate linear regression to assess the association between RFM and total BMD. Appendicular Lean Mass Index (ALMI) was integrated as a core covariate to isolate the metabolic influence of adiposity from its mechanical loading effects. In the unadjusted model, RFM showed no significant correlation with total BMD (β = 0.001, P = 0.122). However, after adjusting for ALMI and other potential confounders, a significant negative association emerged. In the fully adjusted model, each one-unit increase in RFM was associated with a 0.005 g/cm² decrease in total BMD (β = -0.005, P < 0.001). Furthermore, sex-specific non-linear relationships were identified. Threshold effect analysis revealed inflection points at an RFM of 21.28 for males and 39.44 for females. Beyond these respective thresholds, the decline in bone mineral accrual significantly accelerated (P < 0.001). After accounting for the mechanical loading effects of ALMI, higher RFM is independently associated with reduced total BMD in adolescents. These findings reveal observational sex-specific inflection points (21.28 for males, 39.44 for females) beyond which lower BMD was observed. These thresholds should be interpreted as exploratory rather than clinically actionable targets.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying limiting nutrients for wheat (Triticum aestivum L.) production in Halaba, Central Ethiopia.","authors":"Abay Ayalew, Moges Tadese","doi":"10.1038/s41598-026-51398-x","DOIUrl":"https://doi.org/10.1038/s41598-026-51398-x","url":null,"abstract":"<p><p>Low wheat productivity in Ethiopia is largely attributed to nutrient imbalances and the widespread use of blanket fertilizer recommendations that do not account for site-specific soil conditions. To identify the most yield-limiting nutrients for wheat (Triticum aestivum L.) production, a field experiment using nutrient omission trials was conducted during the 2021 cropping season at eight farmers' fields in Wera Dijo District, Halaba Zone, central Ethiopia. The soils across the study sites had neutral pH (6.1-7.0), medium to high organic carbon content (1.85-4.19%), and low to medium available phosphorus (3.10-10.94 mg kg⁻¹). The experiment was arranged in a randomized complete block design with ten treatments, including a complete nutrient treatment, NP treatment, negative control, and single-nutrient omission treatments. Grain yield, biomass yield, and yield components were analyzed using a linear mixed-effects model, with nutrient treatments as fixed effects and farms and blocks within farms as random effects. Nutrient treatments significantly affected grain yield, biomass, and yield components (p < 0.0001). Omission of nitrogen or phosphorus caused significant reductions in all measured parameters, with nitrogen omission resulting in the greatest yield loss, comparable to the negative control, indicating that nitrogen was the most limiting nutrient. In contrast, omission of potassium, sulfur, zinc, or boron had no significant effect on wheat yield, suggesting that these nutrients are not currently limiting in the study area. Grain yields under the NP treatment were statistically comparable to those under the complete treatment. These results highlight nitrogen and phosphorus as the primary yield-limiting nutrients for wheat production in the study area and demonstrate the importance of site-specific nutrient management. Targeted application of N and P fertilizers can improve wheat productivity and nutrient use efficiency in Halaba and similar agro-ecological zones.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning-based cognitive control: developmental trajectories in children aged 5- to 14- years.","authors":"Lisa Toffoli, Giulia Stefanelli, Fiorella Del Popolo Cristaldi, Gian Marco Duma, Massimiliano Pastore, Vincenza Tarantino, Agnes Blaye, Corentin Gonthier, Giovanni Mento","doi":"10.1038/s41598-026-51912-1","DOIUrl":"https://doi.org/10.1038/s41598-026-51912-1","url":null,"abstract":"<p><p>Learning-based cognitive control (CC)-the ability to implicitly adapt control based on contextual regularities-has been studied in young, typically developing children, yet its developmental trajectory remains underexplored. This study examined how learning-based CC develops across childhood under increasing cognitive demands. Overall, 149 children aged 5-14 years (79 females, M = 9.1 ± 2.6) completed a modified Flanker task and a cued go-noGo task (\"Addy\"). Both tasks included a List-Wide Proportion Congruency (LWPC) manipulation contrasting predictable (mostly congruent/valid) and unpredictable (50%) contexts. Reaction times (RTs), accuracy, and delta scores (incongruent/invalid-congruent/valid RTs) were analyzed. In the Flanker task, LWPC effects were similar across ages, suggesting that learning-based CC emerges early and remains stable in low-demand contexts. In contrast, in the Addy task-requiring greater attentional control and motor inhibition-developmental differences emerged. Younger children adapted behaviour by favoring speed over accuracy, while from around 9 years of age children displayed a more balanced speed-accuracy trade-off and improved accuracy, indicating greater efficiency in managing competing task demands. These findings suggest that learning-based inhibitory CC efficiency under complex, multi-demand conditions continues to develop across childhood and highlight the value of ecologically valid paradigms.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear dimensionality reduction and Bayesian optimization for accelerating design of materials.","authors":"Muhammad Osman Nadeem Farooqui, Isaac Y Miranda-Valdez, Tero Mäkinen, Juha Koivisto, Mikko J Alava","doi":"10.1038/s41598-026-51517-8","DOIUrl":"https://doi.org/10.1038/s41598-026-51517-8","url":null,"abstract":"<p><p>Optimizing biobased foam formulations is challenging because experiments are costly and fast-to-measure surrogate properties occupy high-dimensional spaces. Bayesian optimization (BO) with Gaussian process regression (GPR) can guide data-efficient searches, but its performance depends on the dimensionality of the inputs. Here, we evaluate nonlinear dimensionality reduction (DR) methods, namely t-distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation and projection (UMAP), in comparison with principal component analysis (PCA) for biobased foam optimization. Using an existing dataset comprising 26 distinct methylcellulose-cellulose fiber foam formulations with rheological and mechanical measurements, we first train a Gaussian process (GP) on low-dimensional representations of rheological observables. BO is then applied in a single-step, non-sequential manner on this fixed dataset, to evaluate the quality of the latent representations and identify high-yield-stress regions. A second GP maps foam-formulation compositions to the reduced rheological coordinates, enabling reconstruction of candidate formulations in the composition space. Across all DR methods, BO identifies similar high-performing formulations achieving yield stress values comparable to the experimentally validated optimum. PCA acts as a baseline due to its deterministic and hyperparameter-free nature, while nonlinear methods can achieve comparable performance when appropriately tuned. These findings demonstrate that nonlinear DR-assisted BO provides a data-efficient framework for optimizing rheology-governed soft-matter materials.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}