Scientific Reports最新文献

{"title":"Association of serum albumin to creatinine ratio with mortality in patients with aortic disease: a cohort study.","authors":"Weihong Zhao","doi":"10.1038/s41598-025-19240-y","DOIUrl":"https://doi.org/10.1038/s41598-025-19240-y","url":null,"abstract":"<p><p>Most previous studies have only examined the relationship between albumin or creatinine alone and the prognosis of patients with aortic disease (AD). Therefore, the aim of this study was to evaluate the association between serum albumin to creatinine ratio (sACR) and all-cause mortality (ACM) in patients with AD. This retrospective cohort study utilized the Medical Information Mart for Intensive Care IV, stratifying sACR into tertiles. The primary outcome (28-day ACM) and the secondary outcomes in critically ill AD patients were analyzed via restricted cubic splines and multivariate Cox proportional hazards models. Survival differences across sACR tertiles were assessed by Kaplan-Meier analysis, supplemented by subgroup interactions and receiver operating characteristic (ROC) curve evaluation of sACR's prognostic accuracy. This study included 499 AD patients (67.3% male). Multivariate Cox proportional hazards models with log₁₀-transformed sACR revealed each tenfold sACR increase reduced mortality risk by 78% at 28 days (hazard ratio [HR] 0.22, 95% confidence interval [CI] 0.12-0.40), 78% at 90 days (HR 0.22, 95% CI 0.13-0.37), and 74% at 1 year (HR 0.26, 0.17-0.42; all P < 0.001). Restricted cubic splines confirmed linear dose-response relationships (P for non-linear > 0.05). Kaplan-Meier curves demonstrated significantly lower mortality in high sACR tertiles, consistent across subgroups. ROC analysis validated prognostic accuracy. sACR was negatively associated with both short- and long-term mortality in patients with AD. These findings advance prognostic biomarker research by confirming sACR's clinical utility in AD.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35437"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic risk factors and a survival prediction model for immune checkpoint inhibitor related myocarditis in patients with lung cancer: a multicenter study.","authors":"Xiaoyun Cheng, Lingzhi Long, Yuzhang Li, Xia Gan, Pan Yu, Xiangyu Zhang, Guoliang Jiang, Tingting Yao, Mao Jiang, Wei Xie, Jie Meng","doi":"10.1038/s41598-025-19460-2","DOIUrl":"https://doi.org/10.1038/s41598-025-19460-2","url":null,"abstract":"<p><p>Immune checkpoint inhibitor (ICI)-related myocarditis is a rare but fatal immune-related adverse event in lung cancer patients, with limited multivariate prognostic analysis. This study aimed to identify risk factors for severity, major adverse cardiac events (MACE) and survival time, and develop a survival prediction model. Data from 70 lung cancer patients with ICI-related myocarditis (training set) and 40 patients (validation set) were analyzed, with ≥ 1.5 years of follow-up. Cox regression was employed to determine factors associated with survival time, and Logistic regression models identified risk factors for severe myocarditis and MACE. Several factors were independently associated with all-cause death: protective factors included combined radiotherapy (HR 0.12, 95%CI: 0.01-0.98, p = 0.047) and longer ICI treatment duration (≥ 132 days, HR 0.93, 95%CI: 0.91-0.98, p = 0.013); risk factors included low-dose glucocorticoid use in patients with severe myocarditis (HR 3.92, 95%CI: 1.16-13.2, p = 0.028). A nomogram model constructed based on these three variables yielded area under the time-ROC curves of 0.832, 0.835, and 0.924 for 0.5-, 1-, and 1.5-year survival in the training set, and 0.821, 0.806, and 0.789 in the validation set, respectively. It also demonstrated good discriminative ability and clinical utility for predicting survival in lung cancer patients with ICI-related myocarditis, as this study established a validated nomogram model that may aid survival prediction in this population. Additionally, we analyzed the risk factors for severe ICI related myocarditis and 90-day MACE. We found that the use of angiogenesis inhibitors was an independent risk factor for severe myocarditis (OR 18.72, 95% CI: 2.52-428.27, p = 0.02); a history of coronary artery disease (OR 10.54, 95% CI: 1.62-210.10, p = 0.037) was an independent risk factor for 90-day MACE; and left ventricular ejection fraction (OR 0.94, 95% CI: 0.88-0.99, p = 0.026) was an independent protective factor against 90-day MACE.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35514"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an egg production intervention with social behavioral change communication and subsidy on child dietary diversity in Ethiopia.","authors":"Getu Gizaw, Nega Mekonnen, Asres Mamo, Abebe Fekadie, Sharew Nigussie, Mekonnen G/Egziabher, Wubishet Mekonin, Shifera Girma, Samuel Mulat, Afomia Mekonnen, Kalkidan Nigussie, Monique Henriette Beun","doi":"10.1038/s41598-025-19603-5","DOIUrl":"https://doi.org/10.1038/s41598-025-19603-5","url":null,"abstract":"<p><p>Undernutrition remains a major cause of child morbidity and mortality globally, with poor dietary diversity-particularly the limited intake of animal-source foods-being a key factor. In Ethiopia, egg consumption is low, with only 13 eggs per person annually. This study assessed the impact of the Market-based Innovation for Nutrition in Ethiopia (MINE) project, which implemented the Egg Hub model to enhance egg production and marketing, and introduced a social behavior change communication (SBCC) and egg subsidy scheme to increase the demand for eggs among children aged 6-23 months. A four-round repeated cross-sectional survey was conducted in Bishoftu and East Shoa Zone targeting children aged 6-23 months. Children's dietary diversity was assessed using the minimum dietary diversity (MDD) indicator via 24-h recall, while maternal knowledge and attitudes toward child feeding were assessed using a seven-item questionnaire. The primary outcome-change in MDD-was analyzed using multiple logistic regression, with qualitative interviews conducted to supplement quantitative findings. Results showed that the proportion of children achieving MDD increased from 29.7% in the first survey to 76.2% in the fourth. Egg consumption rose from 23.6% to 74.5% across the same period. Maternal knowledge on child feeding improved from 52.7% to 78.2%, and positive attitudes toward recommended feeding practices rose from 76.3% to 87.2%. The Egg Hub model, combined with the comprehensive SBCC and egg subsidy scheme implemented in the MINE project, significantly improved MDD. Scaling up this intervention is recommended to enhance child nutrition at a broader level.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35501"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable antenna for biomedical applications: electromagnetic, SAR, and thermal performance evaluation.","authors":"Amr Shabana, Ahmed El-Bakry, Shimaa Mahdy","doi":"10.1038/s41598-025-21600-7","DOIUrl":"https://doi.org/10.1038/s41598-025-21600-7","url":null,"abstract":"","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35404"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity exacerbates experimental colitis due to the activation of the local renin-angiotensin system in the colon.","authors":"Maomao Pan, Qiang Xu, Linjing Huang, Yuanyuan Bai, Xue Li, Yibing Tang","doi":"10.1038/s41598-025-19294-y","DOIUrl":"https://doi.org/10.1038/s41598-025-19294-y","url":null,"abstract":"<p><p>Obesity is recognized as a risk factor for inflammatory bowel disease (IBD) and may contribute to its progression. However, the underlying mechanisms remain unclear. This study aimed to investigate the impact of high-fat diet (HFD)-induced obesity on the development of experimental colitis, with a particular focus on the role of the gut renin-angiotensin system (RAS) in this process. C57BL/6J mice were assigned to either a low-fat diet (LFD) or HFD for 10 weeks to establish an obesity model.The severity of colitis was significantly greater in obese mice compared to those fed the LFD. Additionally, obesity was associated with increased levels of IL-6, IFN-γ, and TNF-α, while simultaneously downregulating the expression of occludin proteins in the colon, leading to increased colonic permeability in the obese mice. Following colitis induction, HFD -induced obesity activated the RAS by upregulating the expression of angiotensin II receptor, angiotensinogen, and renin in the colon. Treatment with a RAS inhibitor significantly alleviated the symptoms of colitis in the obese mice. These findings suggest that HFD-induced obesity enhances intestinal mucosal barrier permeability and exacerbates mucosal inflammation through the activation of the local RAS, thereby promoting colitis.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35479"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting health-related quality of life following axillary lymph node dissection among breast cancer survivors in Egypt.","authors":"Horeya Mohamed Ismail, Mostafa Ahmed Arafa, Mohamed Mostafa Tahoun, Ahmed Nabil Shama, Amr Abdel Aziz Elsaid","doi":"10.1038/s41598-025-21445-0","DOIUrl":"https://doi.org/10.1038/s41598-025-21445-0","url":null,"abstract":"<p><p>Axillary lymph node dissection (ALND) remains a standard component in the management of breast cancer; however, it may have lasting impacts on patients' health-related quality of life (HRQOL). This study aimed to assess HRQOL and identify its demographic and clinical correlates among breast cancer survivors who underwent ALND. This cross-sectional study was conducted among breast cancer survivors post-ALND at a tertiary oncology center in Alexandria, Egypt. HRQOL was measured using the Arabic FACT-B (version 4.0), and the associated factors were analyzed using multivariate analysis of variance (MANOVA). A total of 150 breast cancer survivors completed the FACT-B questionnaire, with a mean HRQOL score of 88.92 ± 18.01. Of the participants, 18.7% had poor, 64.0% had moderate, and 17.3% had good HRQOL. MANOVA showed that the type of surgery, BMI, HER2 status, lymph node involvement, and tumor stage were significantly associated with HRQOL (p < 0.05). Between-subject analyses and post hoc comparisons confirmed significant group differences across the FACT-B subscales. Overweight or obese participants had poorer Physical, Emotional, and Functional Well-Being. Mastectomy, HER2-positive status, and Stage III disease were associated with lower HRQOL across multiple domains, while lymph node involvement impacted the Physical Well-Being subscale only. Integrating routine HRQOL assessment into survivorship care is essential for identifying individuals at a higher risk of poor outcomes. Tailored follow-up strategies and supportive interventions for these subgroups can enhance the long-term well-being and improve the overall post-treatment quality of life of breast cancer survivors.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35402"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strength hardening and damage mechanism of semiwetted coal under cyclic loads with different initial stress levels.","authors":"Feixiang Lv, Yong Zhang, Fanjie Kong, Xiaobin Li, Quanle Zou","doi":"10.1038/s41598-025-19477-7","DOIUrl":"https://doi.org/10.1038/s41598-025-19477-7","url":null,"abstract":"<p><p>When a coal pillar serves as part of the dam structure in an underground coal mine reservoir, it is subjected to the combined effects of water immersion and dynamic loading. Therefore, understanding the mechanical properties of coal under such conditions is crucial for assessing the stability of underground coal mine reservoirs. While previous studies have investigated the mechanical behavior of coal under cyclic loading conditions, systematic research remains limited regarding structural evolution and mechanical response characteristics under varying initial stress levels in partially saturated environments, particularly for underground reservoir applications. This study investigates the mechanical properties of semi-wetting coal under cyclic loading and unloading at varying initial stress levels, with a focus on stress-strain characteristics, modulus changes, deformation, failure, and energy evolution. The results show that both the strength and the loading/unloading modulus of coal decrease as the initial stress level increases. However, the coal's strength remains higher than its conventional uniaxial compressive strength, indicating a hardening effect due to cyclic loading. This hardening diminishes with higher initial stress levels. Additionally, larger particle sizes and fewer small fragments are observed as initial stress levels rise, suggesting that at lower stress levels, new cracks form but tend to reclose, improving strength and deformation resistance. The cumulative dissipated energy decreases with lower stress levels, highlighting that more energy is required to induce failure at these conditions, further confirming the hardening effect. These findings offer a theoretical foundation for assessing the impact of dynamic loading on coal structure stability under varying initial stress levels.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35543"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete cox 1 gene and ITS sequence of Hirudinaria manillensis and molecular evolution analysis.","authors":"Wenyi Wang, Chaojie Yang, Guangzong He, Weitao Zhao, Jinshen Yang, Yaojun Yang","doi":"10.1038/s41598-025-19661-9","DOIUrl":"https://doi.org/10.1038/s41598-025-19661-9","url":null,"abstract":"<p><p>Hirudinaria manillensis is an important blood-sucking medicinal leech widely distributed in Southeast Asia and southern China. It has been shown to treat cardiovascular and cerebrovascular diseases. Molecular identification technology has developed rapidly, and the results are accurate and stable, which can help us to obtain rich biological information of samples for genetic evolution analysis. This study designed 3 pairs of primers for complete cox 1 gene. After sequencing by PCR products and splicing by SeqMan software, the full-length sequence of cox 1 gene was obtained by annotation of open reading frame (ORFs) on MITOS2 platform. The cox 1 gene with a length of 1536nt was obtained, and the species was identified as Hirudinaria manillensis. The Hd value and FST value of cox 1 gene were 0.858 and 0.10938, which were higher than the Hd value of ITS (0.314) and the FST value close to 0. The nucleotide diversity and GST values of the two genes were very low, and the Tajima's D values of the neutral test were negative, without statistical significance. The genetic distance calculated by the Kimura-2 parameter method was very low. According to the biological information provided by the samples in this study, the population size of Hirudinaria manillensis in southern China was on the rise, but stable genetic diversity was not formed, and there was no obvious population differentiation and geographical isolation. This may be due to the mature artificial breeding technology in recent years, which enabled Hirudinaria manillensis to migrate from the traditional gathering places and breed in a large number in the new environment and migration site. At present, there are many molecular barcoding data of cox 1 gene in the NCBI database, but there is no complete cox 1 gene sequence as a reference, and the related ITS sequence information is more limited, indicating that there is still a lot of space for gene research of Hirudinaria manillensis.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35511"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of sequential model-based optimizer integrated machine learning models in correlation of famotidine solubility in supercritical carbon dioxide.","authors":"Hadil Faris Alotaibi, Chou-Yi Hsu, Fadhil Faez Sead, Anupam Yadav, Renuka S Jyothi, Swati Mishra, Bilakshan Purohit, Egambergan Khudaynazarov, Murodjon Yaxshimuratov, Ashish Singh Chauhan","doi":"10.1038/s41598-025-19491-9","DOIUrl":"https://doi.org/10.1038/s41598-025-19491-9","url":null,"abstract":"<p><p>We investigated solubility variations of a medication in supercritical carbon dioxide with an insight into preparation of nanomedicines with improved aqueous solubility. As the case study, the solubility of famotidine (FAM) medicine in sc-CO₂ (supercritical carbon dioxide) was computed as a function of temperature and pressure, with a particular focus on modeling and predicting solubility and sc-CO₂ density. Three regression models with machine learning behavior including Quadratic Polynomial Regression (QPR), Weighted Least Squares (WLS), and Orthogonal Matching Pursuit (OMP) were employed to analyze the data, and Sequential Model-Based Optimization (SMBO) was utilized for hyper-parameter tuning. Among these models, the best-performing model for predicting FAM solubility was the QPR model, with an impressive coefficient of determination (R²) of 0.95858 for all sets including training and validation. Additionally, QPR exhibited low MAPE of 1.64278E + 00, RMSE of 9.6833E-02, and a maximum error of 1.49480E-01, while exhibiting a higher maximum error of 18.99 kg/m³ for density predictions, indicating areas for potential improvement. These results highlight the accuracy and precision of the QPR model in predicting FAM solubility in sc-CO₂. For the prediction of sc-CO₂ density, QPR again proved to be the most effective model with a remarkable R² score of 0.99733. This model achieved a low MAPE of 1.06004E-02, RMSE of 8.4072E + 00, and a maximum error of 1.89894E + 01. The QPR model demonstrates its exceptional capability in accurately predicting sc-CO₂ density in terms of temperature and pressure.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35555"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying effects of PM_2.5 and O₃ on heat-related cardiorespiratory hospitalizations in Brazil.","authors":"Weeberb J Requia, Heresh Amini, Paulo Hilario Nascimento Saldiva","doi":"10.1038/s41598-025-19542-1","DOIUrl":"https://doi.org/10.1038/s41598-025-19542-1","url":null,"abstract":"<p><p>Extreme heat is a critical public health threat, particularly in low- and middle-income countries. While its direct health impacts are well documented, less is known about how air pollution modifies heat-related risks. We analyzed daily hospital admissions for circulatory and respiratory diseases in Brazil (2008-2018), combined with high-resolution temperature and pollution (PM₂.₅ and O₃) data. Using generalized additive models and random-effects meta-analysis, we found that PM₂.₅ consistently amplified the effect of heat on respiratory admissions, with a 20.1% increase in risk under high PM₂.₅ conditions (95% CI 4.8-35.4%). In contrast, O₃ showed heterogeneous effects, including a national-level protective association at high concentrations (- 7.6%, 95% CI - 9.6 to - 5.6%). Regional analyses revealed stronger interactions in the North and Southeast. These findings indicate that PM₂.₅ exacerbates, and O₃ variably modifies, heat-related hospitalizations in Brazil, underscoring the need for regionally tailored adaptation and air quality policies.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35503"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}