Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-07-26 DOI:10.1038/s41598-025-12355-2

Addisu Melake, Endalech Nakachew

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Abstract

Vitamin D receptor genes, including FokI gene polymorphisms, have been widely studied and shown to be associated with susceptibility to type 2 diabetes mellitus in various populations. The objective of this study was to determine the association between vitamin D receptor FokI gene polymorphisms and the risk of type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Seventy type 2 diabetes mellitus patients and 70 healthy controls participated in an age- and sex-matched hospital-based case-control study. We assessed demographic data to determine the related risk factors. Deoxyribonucleic acid was extracted from blood samples and subjected to polymerase chain reaction and agarose gel electrophoresis analysis to determine the FokI genotypes. Both the FokI ff genotype (odds ratio 3.16; 95% confidence level 1.25-7.75; P = 0.012) and f allele (odds ratio 2.21; 95% confidence level 1.35-3.62; P = 0.0015) were substantially more prevalent in patients than in controls, suggesting that they may be risk factors for the development of type 2 diabetes mellitus. The findings point to a potential link between FokI gene polymorphisms and the development of type 2 diabetes mellitus in the Ethiopian population under study.

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埃塞俄比亚人群中维生素D受体FokI基因多态性与2型糖尿病风险之间的关系

维生素D受体基因，包括FokI基因多态性，已被广泛研究，并显示与不同人群对2型糖尿病的易感性相关。本研究的目的是确定维生素D受体FokI基因多态性与埃塞俄比亚西北部贡达尔大学综合专科医院2型糖尿病风险之间的关系。70名2型糖尿病患者和70名健康对照者参加了一项年龄和性别匹配的医院病例对照研究。我们评估了人口统计数据以确定相关的危险因素。从血样中提取脱氧核糖核酸，进行聚合酶链反应和琼脂糖凝胶电泳分析，确定福氏菌基因型。FokI ff基因型(优势比3.16；95%置信水平1.25-7.75；P = 0.012)和f等位基因(优势比2.21；95%置信水平1.35-3.62；P = 0.0015)在患者中比对照组更为普遍，这表明它们可能是2型糖尿病发展的危险因素。研究结果指出，在被研究的埃塞俄比亚人群中，FokI基因多态性与2型糖尿病的发展之间存在潜在的联系。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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