Scientific Reports最新文献

{"title":"Triaxial compression and shear strength characteristics of two-stage concrete: an experimental study.","authors":"Farzam Omidi Moaf, Ali M Rajabi, Hakim S Abdelgader, Marzena Kurpińska, G Murali, Mikołaj Miśkiewicz","doi":"10.1038/s41598-024-81112-8","DOIUrl":"https://doi.org/10.1038/s41598-024-81112-8","url":null,"abstract":"<p><p>The research necessity stems from the need to understand and evaluate the performance of Two-Stage Concrete (TSC) under triaxial compression conditions, as prior studies have predominantly focused on uniaxial and biaxial testing of conventional concrete (CC). This study represents the first comprehensive investigation into the triaxial compressive strength and related mechanical properties of TSC, addressing a critical gap in the existing body of literature. Three different mixtures were prepared, including one CC and two TSC variants with varying cement content. The results and behavior of these mixtures were compared to assess their performance. Findings reveal that TSC, particularly those types with finer aggregates, demonstrates superior shear strength, achieving up to 52.4 MPa under dry conditions, in contrast to the 48.38 MPa observed in CC. Furthermore, TSC exhibits remarkable stress tolerance, withstanding up to 82.04 MPa, significantly outperforming CC, which withstands only 69.61 MPa under similar conditions. This behavior can be attributed to the higher coarse aggregate content, the increased interaction and contact points between coarse aggregates, the improved bonding between them, and the inherent properties of the grout. TSC also maintains a higher modulus of elasticity and internal friction angles, indicating superior deformation behavior and shear resistance. Additionally, TSC shows greater resilience to moisture, suggesting its potential suitability for use in variable moisture environments. These properties highlight the strength of TSC for high-load applications and its suitability for infrastructure prone to environmental fluctuations.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29396"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular insult in neonatal retinal hemorrhage: computational analysis of a fundus-segmented blood vessel network.","authors":"Matthew R Lam, Jose A Colmenarez, Pengfei Dong, Linxia Gu, Donny W Suh","doi":"10.1038/s41598-024-71509-w","DOIUrl":"https://doi.org/10.1038/s41598-024-71509-w","url":null,"abstract":"<p><p>Common hypotheses for the biomechanical cause underlying neonatal retinal hemorrhage include elevated intracranial pressure (ICP) inducing venous outflow obstruction and retinal deformation. A finite element computational model of the eye, optic nerve, and orbit was simulated with particular attention to the retinal vessels to analyze stress and strain on these structures during external head compression associated with normal vaginal delivery. Pressure from maternal contractions displaced the eye backward into the orbit, and the stiff optic nerve sheath provided localized resistance to this posterior displacement at its insertion point, resulting in tensile strain of 2.5% in the peripapillary (central) retina. Correspondingly, retinal vessels experienced tensile stress of up to 2.3 kPa near the optic nerve insertion point and opposing compressive stress of up to 3.2 kPa further away. The optic nerve was longitudinally compressed and experienced a mean radial tensile strain of 2.0%. Overall, forces associated with maternal labor resulted in a pattern of eye deformation that stretched the central retina in this simulation, mirroring the classical posterior localization of neonatal retinal hemorrhage. The optic nerve increased modestly in diameter despite rising ICP, suggesting retinal deformation is a more likely mechanism for retinal hemorrhage than occlusion of the central retinal vein.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29331"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital design framework for the dimensional optimization of parallel robots based on kinematic and elasto-dynamic performance.","authors":"Yue Ma, Weihua Sun, Hongye Wu, Bin Li, Qi Liu, Songtao Liu, Chenglin Dong, Dun Peng","doi":"10.1038/s41598-024-80413-2","DOIUrl":"https://doi.org/10.1038/s41598-024-80413-2","url":null,"abstract":"<p><p>The dimensional optimization based on kinematic and dynamic performance indices is proven significant for improving the operational performance of parallel robots. As the pose-dependent performances vary with the dimensional parameters, there are still many challenges in the optimal design of parallel robots, such as the possible conflict amongst different performance indices and computational expensiveness. By considering a 4-DOF high-speed parallel robot as an illustrative example, this paper presents a framework for the optimal design of parallel robots by integrating skeleton modeling, CAD-CAE integration and multi-objective optimization techniques. In this approach, the models for kinematic and elasto-dynamic performance evaluation are first developed using the CAD and CAE techniques, respectively. After evaluating the performance distributions over the task workspace, several reference poses representative of multiple neighboring sample poses are determined to formulate corresponding local performance indices by using the Hard C-Means (HCM) clustering analysis algorithm. This consideration leads to the determination of the optimal dimensions by investigating the Pareto-optimal solutions of a multi-objective optimization problem, allowing the conflict amongst different performance indices to be appropriately handled and the computational time to be saved significantly. The results of the case study show that the proposed approach can significantly enhance the elastic dynamic performance while ensuring that the kinematic performance is not excessively compromised, when compared to the performance of existing physical prototype of the robot. A software package has been developed using the proposed framework, providing a highly accessible way for designing various types of parallel/hybrid robots based on CAD and CAE techniques.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29292"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a two step antimicrobial stewardship program in a paediatric haematology and oncology unit.","authors":"Cecilia Liberati, Elisa Barbieri, Francesca Cavagnero, Maria Grazia Petris, Giulia Brigadoi, Giulia Reggiani, Marica De Pieri, Marta Pierobon, Antonio Marzollo, Maria Gabelli, Sabrina Trivellato, Erika Rigotti, Francesca Opri, Daniele Mengato, Francesca Venturini, Ettore De Canale, Claudia Del Vecchio, Carlo Giaquinto, Elena Carrara, Evelina Tacconelli, Alessandra Biffi, Daniele Donà","doi":"10.1038/s41598-024-80163-1","DOIUrl":"https://doi.org/10.1038/s41598-024-80163-1","url":null,"abstract":"<p><strong>Objective: </strong>To describe the implementation of a multi-step antimicrobial stewardship program in a haemato-oncology and stem cell transplantation program unit. Methods: Pre-post quasi-experimental study with two interrupted time-series analyses, conducted between 01/01/2019 and 31/12/2022 in the Paediatric Haemato-Oncology Unit of the Padua Paediatric Hospital. The interventions were: (1) 02/2020: dissemination of febrile neutropenia clinical pathways, (2) April 2021: provision of the clinical pathways via a customized App (Firstline.org) and implementation of a twice-a-week prospective audit and feedback. The main outcome was antibiotic consumption measured by days of administered therapy (DOTs)/1000 patients' days for all antibiotics and most used molecules.</p><p><strong>Results: </strong>The first intervention (clinical pathways) resulted in a decrease in the overall antibiotic use by the haemato-oncology unit, with an abrupt reduction of 3-gen cephalosporins in favor of piperacillin-tazobactam, as indicated by the clinical pathways. Meropenem and glycopeptide use did not vary. The second intervention (antimicrobial stewardship) further decreased total antibiotic consumption, and a significant decline in meropenem, amikacin, and glycopeptides was achieved.</p><p><strong>Conclusions: </strong>Multi-step stewardship based on guidelines dissemination, multidisciplinary team intervention and collaboration (\"handshake\" stewardship) was highly effective in optimizing guidelines adherence and reducing overprescriptions in a fragile patient cohort.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29296"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ship detection using ensemble deep learning techniques from synthetic aperture radar imagery.","authors":"Himanshu Gupta, Om Prakash Verma, Tarun Kumar Sharma, Hirdesh Varshney, Saurabh Agarwal, Wooguil Pak","doi":"10.1038/s41598-024-80239-y","DOIUrl":"https://doi.org/10.1038/s41598-024-80239-y","url":null,"abstract":"<p><p>Synthetic Aperture Radar (SAR) integrated with deep learning has been widely used in several military and civilian applications, such as border patrolling, to monitor and regulate the movement of people and goods across land, air, and maritime borders. Amongst these, maritime borders confront different threats and challenges. Therefore, SAR-based ship detection becomes essential for naval surveillance in marine traffic management, oil spill detection, illegal fishing, and maritime piracy. However, the model becomes insensitive to small ships due to the wide-scale variance and uneven distribution of ship sizes in SAR images. This increases the difficulties associated with ship recognition, which triggers several false alarms. To effectively address these difficulties, the present work proposes an ensemble model (eYOLO) based on YOLOv4 and YOLOv5. The model utilizes a weighted box fusion technique to fuse the outputs of YOLOv4 and YOLOv5. Also, a generalized intersection over union loss has been adopted in eYOLO which ensures the increased generalization capability of the model with reduced scale sensitivity. The model has been developed end-to-end, and its performance has been validated against other reported results using an open-source SAR-ship dataset. The obtained results authorize the effectiveness of eYOLO in multi-scale ship detection with an F₁ score and mAP of 91.49% and 92.00%, respectively. This highlights the efficacy of eYOLO in multi-scale ship detection using SAR imagery.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29397"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-band reflective polarizer based meta-surface with higher angular stability for C and X-band applications.","authors":"Saranya Madheswaran, Rajeshkumar Venkatesan","doi":"10.1038/s41598-024-80734-2","DOIUrl":"https://doi.org/10.1038/s41598-024-80734-2","url":null,"abstract":"<p><p>A reflective dual-band linear-to-circular polarizer for C and X-band application is presented. The proposed elliptical Frequency Selective Surface (FSS) is capable of enhancing the polarization control and minimizes the cross-polarization compared to traditional circular or square geometries. The linear-to-circular polarization is achieved through two elliptical apertures, where each shape generates orthogonal modes with a 90° phase shift. The inner element targets higher frequencies while the outer element handles lower frequencies, enabling efficient polarization conversion across both bands. The proposed unit cell comprises 14 mm × 14 mm and is fabricated on Rogers RT5880 substrate. It exhibits a reflective polarizer at a center frequency of 7.70 GHz with a bandwidth of (7.64-7.76 GHz) and other at 9.42 GHz with a bandwidth of (9.27-9.57 GHz), respectively. In the proposed FSS, the 7.70 GHz exhibits LH-CP, and RH-CP conversion is provided at 9.42 GHz. In addition, an axial ratio of the FSS of (< 3 dB) demonstrated a circular polarization with a polarization conversion ratio (PCR) of 99.9%. In addition, an equivalent circuit model (ECM) of a reflective polarizer has been verified. Furthermore, angular stability of the FSS can be achieved at various incident angles at 0°, 30°, 60°, and 90°. The polarization conversion operates in frequency bands of C-/X, suitable for wireless systems, radar systems, electromagnetic shielding, and satellite communications.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29353"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a weight loss diet with or without Spirulina supplementation on serum lipids and antioxidant capacity of overweight dogs.","authors":"Davide Stefanutti, Lorenzo Serva, Michele Berlanda, Federico Bonsembiante, Gianfranco Gabai, Erica Franceschinis, Marco Cavazzoni, Giada Morelli, Rebecca Ricci","doi":"10.1038/s41598-024-80843-y","DOIUrl":"https://doi.org/10.1038/s41598-024-80843-y","url":null,"abstract":"<p><p>Obesity is a major health issue in dogs associated with disturbances in lipid metabolism and oxidative stress. Spirulina has been shown to have hypolipidemic and antioxidant effects in various animal species. No such data regarding dogs are available, however. The present study aimed to investigate the effect of a therapeutic high-protein, high-fiber weight loss diet, with or without Spirulina supplementation, on biochemical parameters of overweight dogs, with particular reference to serum lipids and plasma antioxidant capacity. Thirty-two dogs completed a double-blind randomized placebo-controlled trial in which they received either Spirulina (S) or placebo (P) tablets in a body weight-dependent amount for 12 weeks; at the same time, both groups were fed the same calorie-restricted diet. Dogs were weighed weekly and calorie restriction was adjusted accordingly to ensure a 1% body weight loss per week. Blood samples were collected at baseline (T0), after 6 weeks (T1), and after 12 weeks (T2). No difference in body weight loss (S: -11.9 ± 0.8%, P: -10.6 ± 0.8%, p = 0.229) was detected between groups at T2. After 6 weeks and an average weight loss of around 6% (S: -6.7 ± 0.6%, P: -5.9 ± 0.6, p = 0.276), significant reductions of serum total cholesterol, glucose, alkaline phosphatase, paraxonase-1 (all p < 0.0001) and gamma-glutamyltransferase (p < 0.018) were observed in both groups, regardless of supplementation. Plasma antioxidant capacity increased significantly in both groups at T2 (p = 0.0003). Serum triglycerides decreased significantly from T0 to T1 in the Spirulina group (p < 0.0001) but not in the placebo group (p = 0.28); as for the difference between groups, a non-significant trend (p = 0.098) was detected. A significantly higher percentage of dogs (p = 0.028) in the Spirulina group achieved a serum triglycerides reduction > 15% compared to baseline at T1 and > 30% at T2. A treatment effect (p = 0.0416) was found for bilirubin, which decreased only in the Spirulina group. In conclusion, a weight loss of around 6% achieved with a high-protein, high-fiber hypocaloric diet is sufficient to induce significant positive metabolic effects and improve lipid, glucose, and liver enzyme values. Plasma antioxidant capacity was tested in dogs undergoing a weight loss program for the first time, demonstrating that overweight individuals are in a deficient status and that a weight loss of around 10% is able to restore values comparable to those of healthy individuals. The results of this study suggest that Spirulina may manifest a hypotriglyceridemic effect in dogs, even if further research is needed to infer causation. The role Spirulina that supplementation plays in bilirubin metabolism and its related beneficial effect is also worth exploring.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29293"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Anti-aging effect of transplanted amniotic membrane mesenchymal stem cells in a premature aging model of Bmi-1 deficiency.","authors":"Chunfeng Xie, Jianliang Jin, Xianhui Lv, Jianguo Tao, Rong Wang, Dengshun Miao","doi":"10.1038/s41598-024-80756-w","DOIUrl":"https://doi.org/10.1038/s41598-024-80756-w","url":null,"abstract":"","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29315"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing model resolution improves but overestimates global mid-depth circulation simulation.","authors":"Haihong Guo, Zhaohui Chen, Ruichen Zhu, Jinzhuo Cai","doi":"10.1038/s41598-024-80152-4","DOIUrl":"https://doi.org/10.1038/s41598-024-80152-4","url":null,"abstract":"<p><p>Increasing the spatial resolution in climate models has significantly improved the simulation of global upper-layer ocean circulation. However, the ability of high-resolution models to accurately reproduce mid-depth circulation, in terms of strength and direction, still remains uncertain. An analysis of 17 climate models with varying resolutions reveals that both low and high-resolution models depict weaker current speeds compared with observations. High-resolution models demonstrate improved simulations of current speed and flow direction, except in the Southern Ocean. The performance of high-resolution models in regions with strong currents is generally better than in regions with weak flows. Dynamically, increasing the model resolution enhances the representation of temporal variations in mid-depth circulation by effectively capturing mesoscale processes. However, this also results in an overestimation of their intensity by approximately 65% on average across the global ocean.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29356"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel spatial heteroscedastic generalized additive distributed lag model for the spatiotemporal relation between PM_2.5and cardiovascular hospitalization.","authors":"Ali Hadianfar, Helmut Küchenhoff, Shahab MohammadEbrahimi, Azadeh Saki","doi":"10.1038/s41598-024-81036-3","DOIUrl":"https://doi.org/10.1038/s41598-024-81036-3","url":null,"abstract":"<p><p>Many studies have examined the impact of air pollution on cardiovascular hospitalization (CVH), but few have looked at the delayed effects of air pollution on CVH. Additionally, there has been no research on the spatial and temporal differences in how environmental pollutants affect CVH. This study seeks to identify spatial heteroscedasticity in the relation between PM2.5 and CVH by developing a Generalized Additive Distributed Lag (GADL) model. Data on hospitalization due to cardiovascular disease were collected from the Hospital Information System (HIS) of Mashhad University of Medical Science from 2017 to 2020. Air pollution data from 22 air quality monitoring (AQM) stations were obtained from the Environmental Pollution Monitoring Center of Mashhad administrates. Markov Random Field (MRF) smoother was utilized in the GADL model to account for spatial heteroscedasticity in the observations. This developed model is a Spatial Heteroscedastic Generalized Additive Distributed Lag (SHGADL) model. Our use of GADL allowed us to discover a significant relationship between PM2.5 exposures and the risk of CVH at lags 0 and 1 in all districts. Our results reveal heteroscedasticity in the Relative Risks (RR) of PM2.5 on CVH across different districts. After accounting for this spatial heteroscedasticity, we found that the RR of PM2.5 on CVH at lags 0 and 1 were 1.0102 (95% CI: 1.0034, 1.0170) and 1.0043 (95% CI: 1.0009, 1.0078) respectively. The central and southeastern districts showed higher RR for CVH. The developed SHGADL model provides evidence of a significant lagged effect of PM2.5 exposures on CVH, and identifies low- and high-risk districts for CVH in Mashhad. This finding can assist decision-makers in allocating resources and planning strategically, with a focus on local interventions to manage ambient air pollution and providing emergency care for CVH.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"14 1","pages":"29346"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}