Scientific Reports最新文献_第6页

Tunnel enabled programmable switches obfuscate network topology to defend against link flooding reconnaissance in software defined networking. 隧道使能的可编程交换机混淆网络拓扑，以防御软件定义网络中的链路泛洪侦察。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19566-7

Xiang Li, Jungmin Lee, Junggab Son, Yeonjoon Lee

{"title":"Tunnel enabled programmable switches obfuscate network topology to defend against link flooding reconnaissance in software defined networking.","authors":"Xiang Li, Jungmin Lee, Junggab Son, Yeonjoon Lee","doi":"10.1038/s41598-025-19566-7","DOIUrl":"https://doi.org/10.1038/s41598-025-19566-7","url":null,"abstract":"Recently, Software-Defined Networking (SDN) has emerged as an increasingly popular network paradigm due to its virtualization capabilities and flexibility. However, its robustness in link connectivity is threatened by Link Flooding Attacks (LFAs). To launch LFAs, adversaries use probing tools to infer network topologies and identify target links with bottlenecks. Thus, protecting SDN topologies against disclosure is crucial to ensure system security and preserve infrastructure functionality. We propose TEPS (Tunnel-Enabled Programmable Switches), a proactive defense system that dynamically obfuscates network topologies to defend against adversarial reconnaissance in SDN. TEPS generates false topologies by leveraging the flexibility of emerging programmable switches to construct customized tunnels and manipulate probing packets using the P4 language. This prevents adversaries from obtaining accurate knowledge of network topologies, making it difficult to reconstruct the true topologies. Furthermore, TEPS counters Round-Trip Time (RTT)-based fingerprinting attacks by dynamically adjusting packet delays and routing traffic to conceal RTT variations. Our evaluation demonstrates that TEPS effectively reduces the distribution of link importance in network topologies compared to the latest proactive defense method, thereby concealing bottlenecks and disrupting adversarial topology reconnaissance, including thwarting RTT-based fingerprinting attempts. Furthermore, by leveraging the capabilities of P4 switches, TEPS introduces minimal network overhead, with at most a 3% reduction in throughput and a 9.57% increase in resource utilization, showing practical feasibility under real-world operational constraints. By implementing TEPS, network administrators can enhance the security of their SDN infrastructures against LFAs and maintain robust connectivity through a lightweight approach.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35549"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors. 在胞嘧啶碱基编辑器中，UGI在Cas9内的重新定位减少了Cas9依赖的脱靶效应。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19482-w

Zehao Shi, Tian-Lin Cheng

引用次数: 0

Changing climate and its impacts on the dynamics of future malaria transmission over certain endemic regions in India. 气候变化及其对印度某些流行地区未来疟疾传播动态的影响。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-07971-x

Prasanta Kumar Bal, Divya Subash Kumar, Ruchi Singh Parihar, Atul Saini

{"title":"Changing climate and its impacts on the dynamics of future malaria transmission over certain endemic regions in India.","authors":"Prasanta Kumar Bal, Divya Subash Kumar, Ruchi Singh Parihar, Atul Saini","doi":"10.1038/s41598-025-07971-x","DOIUrl":"https://doi.org/10.1038/s41598-025-07971-x","url":null,"abstract":"As climate change plays a major role in evaluating the malaria disease over India, it is highly relevant to assess the spatio-temporal variability of malaria transmission dynamics over different climatic zones in India using modelling studies. In this study, VECTRI (vector-borne disease community model of the International Centre for Theoretical Physics, Trieste) model is simulated to predict the future malaria transmission dynamics over four major climatological zones of India, forced with the different climatic parameters such as temperature and rainfall and non-climatic parameter such as population density. The climate data is obtained from multi model mean of different CMIP6 global climate models under the SSP5-8.5 scenario. Results indicate that there is an overall decrease in EIR (Entomological Inoculation Rate) values of 10 to 30% are seen over most of the Indian regions with an increase in temperature about 4 to 5 °C and rainfall about 10 to 40%, by end of the century (2080s) when compared with the baseline period (1985-2014). However, few exceptions are seen over few parts of western and peninsular region where increase in EIR values are seen. This decrease (increase) in EIR values which describes the intensity of malaria transmission is predominantly controlled by temperature and rainfall during summer (winter) monsoon seasons. Such results from the VECTRI model may be useful for policymakers towards various malaria disease control programs in India and this may provide a basis for climate change impact assessments on malaria risk at a regional scale.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35412"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emergency department quality improvement program improves the prognosis of patients with stroke in Taiwan: A nationwide cohort study. 急诊科质量改善计划改善台湾脑卒中患者预后：一项全国性队列研究。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19386-9

Yen-Jung Chu, Hong-Mo Shih, Yeong-Ruey Chu, Pei-Tseng Kung, Wen-Chen Tsai

{"title":"The emergency department quality improvement program improves the prognosis of patients with stroke in Taiwan: A nationwide cohort study.","authors":"Yen-Jung Chu, Hong-Mo Shih, Yeong-Ruey Chu, Pei-Tseng Kung, Wen-Chen Tsai","doi":"10.1038/s41598-025-19386-9","DOIUrl":"https://doi.org/10.1038/s41598-025-19386-9","url":null,"abstract":"In 2012, Taiwan implemented the Emergency Department Quality Improvement Program (EDQIP) to enhance the quality of care for patients with acute ischemic stroke (AIS). This retrospective study evaluated the program's effectiveness using data from the National Health Insurance Research Database. AIS patients were classified into three groups: a pre-implementation group (2011), and a post-implementation group (2013-2015), which was further subdivided into EDQIP and non-EDQIP groups based on hospital participation and receipt of performance-based incentives. Among 169,434 AIS cases identified between 2013 and 2015, 64,574 patients met the inclusion criteria. Compared to the non-EDQIP group, patients in the EDQIP group demonstrated a 9% absolute reduction in the 30-day mortality rate (6% vs. 15%; adjusted hazard ratio [aHR] = 0.40, 95% confidence interval [CI] = 0.32-0.50) and a 2% absolute reduction in the 72-hour emergency department revisits rate (5% vs. 7%). Additionally, the EDQIP group showed a 9% absolute reduction in 30-day mortality rate compared to the pre-EDQIP group (6% vs. 15%; aHR = 0.39, 95% CI = 0.31-0.49). These findings suggest that the EDQIP may be associated with improved clinical outcomes for AIS patients in Taiwan and may serve as a model for similar quality improvement initiatives worldwide.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35473"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemically-defined medium formulation and adaptation method for supporting growth of endothelial cells. 支持内皮细胞生长的化学定义培养基配方和适应方法。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19226-w

Laura A E Brunmaier, Travis W Walker

{"title":"Chemically-defined medium formulation and adaptation method for supporting growth of endothelial cells.","authors":"Laura A E Brunmaier, Travis W Walker","doi":"10.1038/s41598-025-19226-w","DOIUrl":"https://doi.org/10.1038/s41598-025-19226-w","url":null,"abstract":"Chemically-defined (CD) media offer critical advantages for in vitro systems, requiring consistency, tunability, and component transparency, particularly in applications such as bioassays, drug testing, and translational research. While serum-containing media remain widely used, reliable protocols for adapting cells to CD medium, especially for sensitive adherent cell types, are underreported. This study presents a streamlined protocol for adapting human umbilical vein endothelial cells (HUVECs) to a custom CD medium, with a focus on optimizing weaning strategies and identifying surface coatings that support robust attachment and viability. The protocol evaluates gradual and stepwise adaptation approaches to minimize cellular stress, while incorporating defined extracellular matrix proteins to promote adherence under serum-free conditions. Among tested coatings, fibronectin substantially improved cell attachment and viability during CD medium adaptation, outperforming laminin and collagen IV. To support quantifiable and reproducible tracking of cell growth, we applied a trainable AI-based image analysis method for confluence assessment throughout the adaptation process. This work provides a reproducible, modular framework for transitioning HUVECs, and potentially other human cell lines, to CD medium, while preserving cell health and experimental utility across multiple passages. The methodology may also facilitate the design of quantitative and ethically aligned bioassays, accelerating progress in standardized cell culture practices.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35458"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimising hyperparameters with a tree structured Parzen estimator to improve diabetes prediction. 用树结构Parzen估计器优化超参数以提高糖尿病预测。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19295-x

Raafat M Munshi, Lammar R Munshi, Hanen Himdi, Amjad Qashlan, Reema Munshi, Othman Y Alyahyawy, Mashael M Khayyat

{"title":"Optimising hyperparameters with a tree structured Parzen estimator to improve diabetes prediction.","authors":"Raafat M Munshi, Lammar R Munshi, Hanen Himdi, Amjad Qashlan, Reema Munshi, Othman Y Alyahyawy, Mashael M Khayyat","doi":"10.1038/s41598-025-19295-x","DOIUrl":"https://doi.org/10.1038/s41598-025-19295-x","url":null,"abstract":"Diabetes is a lifelong condition that occurs when the pancreas loses its ability to secrete insulin or experiences a significant reduction in insulin production. Early identification of high-risk patients is crucial for timely interventions and improved outcomes. Traditional clinical risk prediction models rely on regression analysis using clinical, sociodemographic, and anthropometric data; however, they have limitations in terms of accuracy and generalizability. This research proposes a diagnostic strategy leveraging machine learning (ML) techniques, specifically the XGBoost algorithm optimised with Optuna, to enhance high-risk prediction based on laboratory parameters. The study utilises an open-access diabetes dataset incorporating patient demographics, laboratory test results, and clinical outcomes. Data preprocessing, including cleaning, normalisation, and feature extraction, is performed using an Adaptive Tree-Structured Parzen Estimator (ATPE) and XGBoost model. The proposed model outperforms conventional classification models, achieving 83% accuracy, 80% precision, 78% recall, and a 78% F1 score. A comprehensive correlation and confusion matrix evaluation highlights the model's effectiveness in distinguishing high-risk patients. Findings indicate that integrating machine learning (ML)-based risk classification frameworks with laboratory test-based diagnostic strategies improves predictive accuracy and patient stratification. However, data quality, population diversity, and real-time applicability remain challenges. Future research should explore the integration of real-time data from wearable devices and expand model deployment to other chronic and rare diseases, enhancing adaptability and clinical decision-making.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35430"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of six musculoskeletal disorders in women of childbearing age from 1990 to 2021. 1990年至2021年育龄妇女六种肌肉骨骼疾病的全球负担。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19382-z

Haocheng Du, Shi Li, Zichen Tian, Jingbo Lin, Lin Li, Jinzhu Liu, Weibo Xiao, Lingkang Dong, Xintao Zhang

{"title":"Global burden of six musculoskeletal disorders in women of childbearing age from 1990 to 2021.","authors":"Haocheng Du, Shi Li, Zichen Tian, Jingbo Lin, Lin Li, Jinzhu Liu, Weibo Xiao, Lingkang Dong, Xintao Zhang","doi":"10.1038/s41598-025-19382-z","DOIUrl":"https://doi.org/10.1038/s41598-025-19382-z","url":null,"abstract":"Women of childbearing age (WCBA) are a high-risk group for musculoskeletal (MSK) disorders and face significant challenges. A comprehensive analysis is needed to understand the impacts and develop suitable strategies. Detailed data on MSK disorders in WCBA over the past 32 years, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other musculoskeletal disorders (OMSKDs), were collected from the Global Burden of Disease database (GBD2021). The burden of these diseases and trends were assessed using prevalence, disability-adjusted life years (DALYs), the Socio-Demographic Index (SDI), and estimated annual percentage changes , with forecasts made up to 2050.From 1990 to 2021, among WCBA, the number of patients with MSK disorders increased from 245,428,271 to 401,422,090. The rate of increase in prevalence was the greatest in middle SDI regions, while high SDI regions bear the highest age-standardized DALYs rate. The conditions with the most significant increase in Age-Standardized Prevalence Rate are ranked as OA, gout, OMSKDs, RA, and NP, while LBP remained relatively unchanged. The ARIMA model forecasts that the number of cases will further rise, and it is estimated that approximately 500 million WCBA will be affected by MSK diseases by 2050. The contributions of obesity and renal dysfunction to the burden of MSK disorders will further increase.WCBA face a significant burden from MSK disorders, and this burden is forecast to increase further. There is an urgent need to invest more in medical resources to manage MSK conditions in WCBA. Focus on the significant increase in specific MSK disorders and controlling modifiable risk factors is crucial.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35423"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with malnutrition among children aged 6-59 months in Burao, Somaliland. 索马里兰布拉奥6-59个月儿童营养不良相关因素。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-02085-w

Ahmed Adan Jama

{"title":"Factors associated with malnutrition among children aged 6-59 months in Burao, Somaliland.","authors":"Ahmed Adan Jama","doi":"10.1038/s41598-025-02085-w","DOIUrl":"https://doi.org/10.1038/s41598-025-02085-w","url":null,"abstract":"Malnutrition remains a pervasive challenge in Burao, Somaliland, particularly among children aged 6-59 months. This study investigates the multifactorial determinants of malnutrition, focusing on socio-economic status, child care practices, and child characteristics, to inform targeted interventions and policy reforms. A descriptive cross-sectional design was employed, recruiting 144 mother-child pairs from two public hospitals in Burao. Data were collected using structured questionnaires administered to caregivers, capturing socio-economic factors (e.g., income, maternal education), child care practices (e.g., breastfeeding, hygiene), and child characteristics (e.g., age, birth order). Anthropometric measurements (weight, height, mid-upper arm circumference) were used to classify malnutrition (wasting, stunting, underweight). Statistical analyses included Goodman-Kruskal's gamma (γ) to assess ordinal associations and multivariable logistic regression to identify predictors. Significance was set at p < 0.05, with 95% confidence intervals (CIs). The study revealed a high burden of malnutrition: 42% stunting, 30.4% underweight, and 49.3% wasting. Socio-economic deprivation showed a strong correlation with malnutrition (γ = 0.781, p < 0.001), with low-income households (<$100/month) facing nearly triple the risk (aOR = 2.80, 95% CI: 1.70-4.60). Suboptimal child care practices, such as non-exclusive breastfeeding (aOR = 3.60, 95% CI: 2.10-6.20) and poor hygiene (aOR = 1.90, 95% CI: 1.10-3.30), significantly elevated malnutrition odds. Child characteristics, particularly age (12-23 months: aOR = 1.70, 95% CI: 1.10-2.60) and higher birth order (OR = 2.10, 95% CI: 1.30-3.40), demonstrated the strongest association (γ = 0.882, p < 0.001). It is recommended that the Ministry of Health Development prioritize nutritional programs for children under five, enhance child welfare policies, and promote educational initiatives for mothers on exclusive breastfeeding and complementary feeding practices.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35411"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-free thiadiazole-triazine porous polymer modified planar electrodes for electrochemical Hg(II) detection in water. 无金属噻二唑-三嗪多孔聚合物修饰平面电极用于水中汞的电化学检测。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-19241-x

Ankita Dutta Chowdhury, Anirban Ghosh, Tapas Sen, Asim Bhaumik, Somenath Roy

{"title":"Metal-free thiadiazole-triazine porous polymer modified planar electrodes for electrochemical Hg(II) detection in water.","authors":"Ankita Dutta Chowdhury, Anirban Ghosh, Tapas Sen, Asim Bhaumik, Somenath Roy","doi":"10.1038/s41598-025-19241-x","DOIUrl":"https://doi.org/10.1038/s41598-025-19241-x","url":null,"abstract":"The detection and monitoring of mercury ions (Hg2+) in water have become increasingly critical due to their extreme toxicity, bioaccumulation potential, and regulatory significance under international frameworks such as the Minamata Convention. Persistent mercury contamination continues to affect water systems in both developed and developing nations, including India and the United Kingdom. As a step towards detecting mercury (Hg2+) in water samples, we have developed miniaturized point-of-analysis electrochemical sensor based on a new metal-free, thiadiazole (TDA) and triazine (Trz) linked porous organic polymer (TDA-Trz-POP). Unlike conventional sensors that rely on metal-based recognition elements, our heteroatom-rich POP enables highly selective Hg²⁺ capture via synergistic sulphur and nitrogen coordination. The resulting sensors exhibit a lower limit-of-detection (LoD) as 1.5 nM (≈ 0.4 ppb, below the WHO Limit of 6 ppb) and a Linear range of 5-100 nM (1.4 to 27 ppb). The selective and sensitive detection of Hg2+ attributed to the nitrogen- and sulphur-rich surface functionalities of the TDA-Trz-POP-modified electrode, with the underlying binding mechanism is discussed in detail. Using square wave anodic stripping voltammetry (SWASV), we demonstrate real-sample applicability in water, offering a robust, low-cost, and scalable solution for on-site mercury detection in groundwater. The present work is among the first demonstrations of a metal-free porous organic polymer (POP) integrated into SPEs for point-of-analysis mercury sensing with huge potential for public health in developing nations.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35443"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and contributing factors of postpartum depression risk during the pandemic among women living in Baixo Alentejo at Portugal. 大流行期间生活在葡萄牙Baixo Alentejo的妇女产后抑郁风险的流行程度和影响因素。

IF 3.9 2区综合性期刊

Scientific Reports Pub Date : 2025-10-10 DOI: 10.1038/s41598-025-17949-4

Solange Silva, Maria Barros, Otilia Zangão, Úrsula Carvalho, Margarida Sim-Sim

{"title":"Prevalence and contributing factors of postpartum depression risk during the pandemic among women living in Baixo Alentejo at Portugal.","authors":"Solange Silva, Maria Barros, Otilia Zangão, Úrsula Carvalho, Margarida Sim-Sim","doi":"10.1038/s41598-025-17949-4","DOIUrl":"https://doi.org/10.1038/s41598-025-17949-4","url":null,"abstract":"The WHO estimates that postpartum depression occurs in 13-20% of women. It is underdiagnosed and undervalued. The aim is to analyze the prevalence and factors associated with the risk of postpartum depression in times of Pandemic in puerperal women in Baixo-Alentejo, Portugal. Cross-sectional study with 301 participants. The online questionnaire collected sociodemographic data, characteristics of pregnancy, childbirth, puerperium, and also the Edinburgh Postnatal Depression Scale. The statistical analysis used IBM-SPSS. After bivariate analysis, variables with a p-value < .25 were selected. Logistic regression was performed on the potential predictors. Ethical principles were respected. The average age of the participants was 31.35 years (SD = 5.80). At an EPDS total score cut-off of 10, the prevalence of the risk of postpartum depression was 27.57%. Three protective factors associated with the risk of postpartum depression were: a) feeling safe during childbirth (OR .958, 95% CI .942-.974, B = - .043), b) being accompanied in labor by a family member (OR .342, 95% CI .163-.715, B = - 1.074) and c) planning the pregnancy (OR .209, 95% CI .109-.397, B = - 1.568). The model explained 34.3% of the variance in the risk of postpartum depression. The study suggests the need for local health policies. Potentiation of short- and long-term morbidities must be avoided.","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"35420"},"PeriodicalIF":3.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0