Pharmacovigilance analysis of drug-induced hypertrophic rhinitis using FAERS data.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-07-04 DOI:10.1038/s41598-025-10336-z

Yan He, Xinzhou Yan, Long Chen, Zhiqiang Lin

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Abstract

Our study aims to evaluate the risk of drug-induced hypertrophic rhinitis and analyze its epidemiological characteristics utilizing real-world data. We employed reporting odds ratios (ROR) to assess the disproportionality in reports of drug-induced hypertrophic rhinitis between January 2004 and September 2024. Single-factor, LASSO, and multi-factor regression analyses were conducted to investigate drugs associated with hypertrophic rhinitis. The Bonferroni correction was implemented to conduct multiple comparisons. 250 drugs were linked to hypertrophic rhinitis, with 85 drugs (case number > 100) identified as independent risk factors for drug-induced hypertrophic rhinitis. Those drugs' indications were classified as Allergic disease (19/85), Multi-indication (13/85), Cardiovascular disease (12/85), Rheumatoid disease (6/85), Autoimmune disease (6/85), Respiratory disease (5/85), Cancer (4/85), Metabolic disease (4/85), Contrast agent (3/85), Erectile dysfunction (3/85), Infection (3/85), Disease of the nervous system (2/85), Urologic Disease (2/85) Esophageal disease (1/85), Hereditary disorder (1/85), and Ophthalmic disease (1/85). Multiple medications have possible risks of drug-induced hypertrophic rhinitis. Further research is needed to clarify causality and guide clinical decision-making.

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利用FAERS数据分析药物性肥厚性鼻炎的药物警戒性。

我们的研究旨在评估药物性肥厚性鼻炎的风险，并利用现实世界的数据分析其流行病学特征。我们采用报告优势比（ROR）来评估2004年1月至2024年9月间药物性肥厚性鼻炎报告的不相称性。采用单因素、LASSO和多因素回归分析探讨与肥厚性鼻炎相关的药物。采用Bonferroni校正进行多重比较。250种药物与肥厚性鼻炎有关，其中85种药物（病例数bbb100）被确定为药物性肥厚性鼻炎的独立危险因素。适应症依次为过敏性疾病（19/85）、多适应症（13/85）、心血管疾病（12/85）、类风湿疾病（6/85）、自身免疫性疾病（6/85）、呼吸系统疾病（5/85）、癌症（4/85）、代谢性疾病（4/85）、造影剂（3/85）、勃起功能障碍（3/85）、感染（3/85）、神经系统疾病（2/85）、泌尿系统疾病（2/85）、食道疾病（1/85）、遗传性疾病（1/85）、眼科疾病（1/85）。多种药物有可能导致药物性肥厚性鼻炎。需要进一步的研究来澄清因果关系并指导临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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