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Seminars in perinatology最新文献

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Post-resuscitation care in the NICU. 新生儿重症监护室的复苏后护理。
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-10-09 DOI: 10.1016/j.semperi.2024.151993
Mary Haggerty, Monika Bajaj, Girija Natarajan, Anne Ades
{"title":"Post-resuscitation care in the NICU.","authors":"Mary Haggerty, Monika Bajaj, Girija Natarajan, Anne Ades","doi":"10.1016/j.semperi.2024.151993","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.151993","url":null,"abstract":"<p><p>Post-cardiac arrest syndrome is a unique pathophysiologic condition that is well-described in adult and pediatric populations. Early, goal-directed care after cardiac arrest can mitigate ongoing injury, improve clinical outcomes, and prevent re-arrest. There is a paucity of evidence about post-cardiac arrest care in the NICU, however, pediatric principles and guidelines can be applied in the NICU in the appropriate clinical context.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"151993"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemodynamic instability in the transitional period after birth. 出生后过渡时期的血流动力学不稳定。
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-10-09 DOI: 10.1016/j.semperi.2024.151986
Sharada Gowda, Molly K Ball, Satyan Lakshminrusimha, Danielle R Rios, Patrick J McNamara
{"title":"Hemodynamic instability in the transitional period after birth.","authors":"Sharada Gowda, Molly K Ball, Satyan Lakshminrusimha, Danielle R Rios, Patrick J McNamara","doi":"10.1016/j.semperi.2024.151986","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.151986","url":null,"abstract":"<p><p>It is not uncommon for a patient to experience hemodynamic instability following birth. This is due to the fact that the transitional period requires dramatic cardiorespiratory changes. When it goes well, improved lung compliance and successful transition to the postnatal circulation is seen. However, it is highly beneficial that clinicians have a solid understanding of all of the required changes, the unique aspects of the neonatal myocardium, and the influence of cardiovascular disease on normal adaptive mechanisms. In this manuscript, we will review the physiology of the normal postnatal circulatory adaptation, the unique characteristics of the neonatal myocardium and how it behaves in states of altered loading conditions, and the impact of hemodynamic disease states on health and wellbeing during the immediate postnatal time-period.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"151986"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of resuscitation for infants with severe bronchopulmonary dysplasia. 严重支气管肺发育不良婴儿的复苏原则。
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-10-09 DOI: 10.1016/j.semperi.2024.151990
Summer Elshenawy, Monique R Radman-Harrison, Philip T Levy, Satyan Lakshminrusimha, Taylor L Sawyer, Brenda H Law
{"title":"Principles of resuscitation for infants with severe bronchopulmonary dysplasia.","authors":"Summer Elshenawy, Monique R Radman-Harrison, Philip T Levy, Satyan Lakshminrusimha, Taylor L Sawyer, Brenda H Law","doi":"10.1016/j.semperi.2024.151990","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.151990","url":null,"abstract":"<p><p>Severe bronchopulmonary dysplasia (sBPD) requiring invasive mechanical ventilation is a heterogeneous disease process that contributes to morbidity and mortality in infants. As the most common lung disease of prematurity, sBPD has a multitude of overlapping cardiac, airway, pulmonary vascular, and infectious phenotypic presentations that progress through four different phases of care. Premature infants with sBPD are at a high risk of acute decompensation and subsequent cardiopulmonary arrest. A comprehensive determination of the complex phenotypes that contribute to the clinical presentation will help clinicians decipher the phase of care, identify cardiopulmonary compromise earlier and guide targeted therapeutic intervention during acute episodes of deterioration. The approach to resuscitation of premature infants with sBPD undergoing an acute decompensation differs from general neonatal and pediatric resuscitation practices. This review summarizes the phenotypes of sBPD, the phases of care, the common triggers of acute exacerbations, and the principles of resuscitation of a deteriorating infant with sBPD. We offer a framework for sBPD resuscitation with a focus on prevention, assessment, and post-resuscitative care.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"151990"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resuscitation education for NICU providers: Current practice and recommendations for NRP and PALS in the NICU. 为新生儿重症监护室的医护人员提供复苏教育：新生儿重症监护室 NRP 和 PALS 的当前实践和建议。
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-10-09 DOI: 10.1016/j.semperi.2024.151991
Elizabeth Schierholz, Elizabeth A Wetzel, Alyssa R Thomas, Beena D Kamath-Rayne, Danielle J W Reed
{"title":"Resuscitation education for NICU providers: Current practice and recommendations for NRP and PALS in the NICU.","authors":"Elizabeth Schierholz, Elizabeth A Wetzel, Alyssa R Thomas, Beena D Kamath-Rayne, Danielle J W Reed","doi":"10.1016/j.semperi.2024.151991","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.151991","url":null,"abstract":"<p><p>The Neonatal Resuscitation Program (NRP) is the most used resuscitation algorithm for infants requiring resuscitation in the neonatal intensive care unit (NICU). The population of infants cared for in the NICU is varied and complex with resuscitation needs that may extend beyond the NRP algorithm. To provide resuscitation care that addresses these needs, institutions may choose to incorporate algorithms from the Pediatric Advanced Life Support or a \"hybrid\" approach that includes NRP. Limited evidence exists to support one algorithm or approach over another. In this article, we identify potential gaps in the application of using NRP or PALS in the NICU population, present select patient decompensations and discuss the resuscitation management approach using the NRP or PALS algorithms. Challenges associated with NICU resuscitation education will be explored as well as approaches to overcome some of the identified resuscitation education obstacles.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"151991"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special considerations for the stabilization and resuscitation of patients with cardiac disease in the Neonatal Intensive Care Unit. 新生儿重症监护室心脏病患者的稳定和复苏特别注意事项。
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-10-08 DOI: 10.1016/j.semperi.2024.151989
Beth Ann Johnson, Jennifer Shepherd, Shazia Bhombal, Noorjahan Ali, Chloe Joynt
{"title":"Special considerations for the stabilization and resuscitation of patients with cardiac disease in the Neonatal Intensive Care Unit.","authors":"Beth Ann Johnson, Jennifer Shepherd, Shazia Bhombal, Noorjahan Ali, Chloe Joynt","doi":"10.1016/j.semperi.2024.151989","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.151989","url":null,"abstract":"<p><p>Effective resuscitation of neonates with congenital heart disease (CHD) depends on comprehensive planning, thorough understanding of physiology, vigilant monitoring, and interdisciplinary collaboration to achieve the best outcomes. Neonatal heart disease can affect cardiac structure, rhythm, or ventricular function, and may be either congenital or acquired. Critical congenital heart disease (CCHD) can result in inadequate pulmonary blood flow, impaired intracardiac mixing, airway obstruction, or insufficient cardiac output. Tailored resuscitation strategies are important as early as the delivery room, where some CHD lesions may cause immediate cardiovascular instability during the transition from fetal to postnatal circulation. Premature infants with CHD are at higher risk due to their small size and the complications associated with prematurity, affecting both CHD management and overall clinical stability. Addressing both cardiac and non-cardiac causes of decompensation requires a precise understanding of each patient's unique physiology and trajectory from delivery through postintervention intensive care.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"151989"},"PeriodicalIF":3.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of pain, sedation and analgesia on neonatal brain injury and brain development 疼痛、镇静和镇痛对新生儿脑损伤和脑发育的影响
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-08-01 DOI: 10.1016/j.semperi.2024.151928
{"title":"Effects of pain, sedation and analgesia on neonatal brain injury and brain development","authors":"","doi":"10.1016/j.semperi.2024.151928","DOIUrl":"10.1016/j.semperi.2024.151928","url":null,"abstract":"<div><p>Critically ill newborns experience numerous painful procedures as part of lifesaving care in the Neonatal Intensive Care Unit. However, painful exposures in the neonatal period have been associated with alterations in brain maturation and poorer neurodevelopmental outcomes in childhood. The most frequently used medications for pain and sedation in the NICU are opioids, benzodiazepines and sucrose; these have also been associated with abnormalities in brain maturation and neurodevelopment making it challenging to know what the best approach is to treat neonatal pain. This article provides clinicians with an overview of how neonatal exposure to pain as well as analgesic and sedative medications impact brain maturation and neurodevelopmental outcomes in critically ill infants. We also highlight areas in need of future research to develop standardized neonatal pain monitoring and management strategies.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 5","pages":"Article 151928"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146000524000624/pdfft?md5=d710888fa8c40a2ddbb5249b10529286&pid=1-s2.0-S0146000524000624-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental impact during and after neonatal intensive care admission 新生儿重症监护期间和之后对父母的影响
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-08-01 DOI: 10.1016/j.semperi.2024.151926
{"title":"Parental impact during and after neonatal intensive care admission","authors":"","doi":"10.1016/j.semperi.2024.151926","DOIUrl":"10.1016/j.semperi.2024.151926","url":null,"abstract":"<div><p><span>Parents play a pivotal role in neurodevelopmental outcomes of their children in the neonatal intensive care unit (NICU) and beyond. Integration of parents in clinical care and research is synergistic. Engaged parents yield more comprehensive clinical care and more robust and meaningful research products. Subsequently, successful clinical and research efforts improve outcomes for children. We review strategies for parental integration into NICU clinical care and research, including parental involvement in therapeutic interventions and neurodevelopmental care, and effective communication strategies for clinicians and researchers. We discuss challenges in neonatal trials and emphasize the need for building a culture of research, collaborative partnerships with </span>patient advocacy organizations, and ongoing support beyond the NICU. Overall, we call for recognizing and fostering the impactful role of parents as teammates with clinicians and researchers in optimizing neurodevelopmental outcomes in the NICU and beyond.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 5","pages":"Article 151926"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial and geographic disparities in neonatal brain care 新生儿脑部护理的种族和地域差异
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-08-01 DOI: 10.1016/j.semperi.2024.151925
{"title":"Racial and geographic disparities in neonatal brain care","authors":"","doi":"10.1016/j.semperi.2024.151925","DOIUrl":"10.1016/j.semperi.2024.151925","url":null,"abstract":"<div><p>In this review, we explore race-based disparities in neonatology and their impact on brain injury and neurodevelopmental outcomes. We discuss the historical context of healthcare discrimination, focusing on the post-Civil War era and the segregation of healthcare facilities. We highlight the increasing disparity in infant mortality rates between Black and White infants, with premature birth being a major contributing factor, and emphasize the role of prenatal factors such as metabolic syndrome and toxic stress in affecting neonatal health. Furthermore, we examine the geographic and historical aspects of racial disparities, including the consequences of redlining and limited access to healthcare facilities or nutritious food options in Black communities. Finally, we delve into the higher incidence of brain injuries in Black neonates, as well as disparities in adverse neurodevelopmental outcome. This evidence underscores the need for comprehensive efforts to address systemic racism and provide equitable access to healthcare resources.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 5","pages":"Article 151925"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146000524000594/pdfft?md5=22f404a6ca4e469dd12b81fe680a8f89&pid=1-s2.0-S0146000524000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141407722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protecting and healing the newborn brain through non-pharmacologic and pharmacologic measures 通过非药物和药物措施保护和修复新生儿大脑
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-08-01 DOI: 10.1016/j.semperi.2024.151931
{"title":"Protecting and healing the newborn brain through non-pharmacologic and pharmacologic measures","authors":"","doi":"10.1016/j.semperi.2024.151931","DOIUrl":"10.1016/j.semperi.2024.151931","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 5","pages":"Article 151931"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do we reach the goal of personalized medicine for neuroprotection in neonatal hypoxic-ischemic encephalopathy? 如何实现新生儿缺氧缺血性脑病神经保护的个性化医疗目标？
IF 3.2 3区 医学
Seminars in perinatology Pub Date : 2024-08-01 DOI: 10.1016/j.semperi.2024.151930
{"title":"How do we reach the goal of personalized medicine for neuroprotection in neonatal hypoxic-ischemic encephalopathy?","authors":"","doi":"10.1016/j.semperi.2024.151930","DOIUrl":"10.1016/j.semperi.2024.151930","url":null,"abstract":"<div><p>Therapeutic hypothermia is now standard of care for neonates with hypoxic-ischemic encephalopathy (HIE) in high income countries (HIC). Conversely, compelling trial evidence suggests that hypothermia is ineffective, and may be deleterious, in low- and middle-income countries (LMIC), likely reflecting the lower proportion of infants who had sentinel events at birth, suggesting that injury had advanced to a stage when hypothermia is no longer effective. Although hypothermia significantly reduced the risk of death and disability in HICs, many infants survived with disability and in principle may benefit from targeted add-on neuroprotective or neurorestorative therapies. The present review will assess biomarkers that could be used to personalize treatment for babies with HIE – to determine first whether an individual infant is likely to respond to hypothermia, and second, whether additional treatments may be beneficial.</p></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 5","pages":"Article 151930"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0146000524000648/pdfft?md5=ead39b4a98d93ad966f805f4f2126896&pid=1-s2.0-S0146000524000648-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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