Managing pregnancy-associated breast cancer: A practical approach

IF 3.2 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Seminars in perinatology Pub Date : 2025-03-01 DOI:10.1016/j.semperi.2025.152037

Prarthna V. Bhardwaj , Yara Abdou

引用次数: 0

Abstract

Pregnancy-Associated Breast Cancer (PABC) is a rare but complex condition that presents both professional and ethical challenges. Diagnosis is often delayed due to breast changes associated with pregnancy and puerperium, which can mask malignant findings. Management requires a multidisciplinary approach that carefully balances maternal and fetal risks.

Chemotherapy is generally reserved for the second and third trimesters to avoid teratogenicity, with anthracyclines being the most well-studied and safest agents in this setting. Surgical decisions are influenced by factors such as cancer stage, gestational age, and the timing of potential radiation therapy. Notably, radiation therapy, endocrine therapy, and most targeted therapies are contraindicated during pregnancy due to potential harm to the fetus.

Comprehensive care should include robust social and mental health support for the mother and her family to help navigate the physical and emotional challenges during this period.

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管理妊娠相关乳腺癌：一个实用的方法

妊娠相关乳腺癌（PABC）是一种罕见但复杂的疾病，提出了专业和道德挑战。由于与妊娠和产褥期相关的乳房变化，诊断常常被推迟，这可能掩盖了恶性的发现。管理需要多学科的方法，仔细平衡产妇和胎儿的风险。化疗通常保留在妊娠中期和晚期，以避免致畸，在这种情况下，蒽环类药物是研究最充分、最安全的药物。手术决定受癌症分期、胎龄和潜在放射治疗时机等因素的影响。值得注意的是，放射治疗、内分泌治疗和大多数靶向治疗在怀孕期间是禁忌的，因为它们对胎儿有潜在的危害。综合护理应包括为母亲及其家人提供强有力的社会和心理健康支持，以帮助应对这一时期的身体和情感挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in perinatology 医学-妇产科学

CiteScore

5.80

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.