Seminars in perinatology最新文献

Infections during pregnancy: An ongoing threat.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-04-05 DOI: 10.1016/j.semperi.2025.152075

Claudia Fernandes Lorea, Katherine Pressman, Lavinia Schuler-Faccini

{"title":"Infections during pregnancy: An ongoing threat.","authors":"Claudia Fernandes Lorea, Katherine Pressman, Lavinia Schuler-Faccini","doi":"10.1016/j.semperi.2025.152075","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152075","url":null,"abstract":"Congenital infections are an ongoing relevant cause of congenital and perinatal abnormalities since effective vaccination is not available for many diseases. Moreover, climate change, mutational evolution of pathogens, or their vectors associated with intense human traveling predispose to outbreaks and modification of the geographic distribution of traditionally limited infectious diseases. Here, we review the so-called TORCH infections (toxoplasmosis, others, rubella, cytomegalovirus, herpes) with a special emphasis on the arboviral infections (zika, dengue, chikungunya, oropouche). Although respiratory viruses are rarely transmitted through the placenta, the maternal condition itself can cause adverse effects on the developing embryo/fetus (COVID-19, influenza). Some perinatal-acquired infections will also be briefly discussed due to their relevance in the child's development. The majority of teratogenic congenital and some perinatal-acquired infections have effects on the central nervous system or sensory organs with long-lasting disabilities. Vaccines are unavailable for several teratogenic or perinatal infections, and treatment options are still limited, particularly for arboviral and other emergent diseases. Social inequalities are associated with the prevalence, fetal outcomes and long-term disabilities of these diseases. The One Health approach could be an essential way to reduce the burden of these diseases in the population.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152075"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drugs in Lactation.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-04-02 DOI: 10.1016/j.semperi.2025.152077

Margarita A P Berwick, Anika J Heuberger, Joimishael V Martin, Thomas W Hale, Adetola F Louis-Jacques

引用次数: 0

Pain medication use during pregnancy.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-04-01 DOI: 10.1016/j.semperi.2025.152074

Rebecca A Nunge, Anthony M Kendle, Sura Alwan

引用次数: 0

Perinatal psychiatry: balancing maternal-fetal exposures to mental disorders and drug treatments.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-28 DOI: 10.1016/j.semperi.2025.152076

Anne M Nielsen, Catherine S Stika, Katherine L Wisner

{"title":"Perinatal psychiatry: balancing maternal-fetal exposures to mental disorders and drug treatments.","authors":"Anne M Nielsen, Catherine S Stika, Katherine L Wisner","doi":"10.1016/j.semperi.2025.152076","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152076","url":null,"abstract":"Introduction: The potential effects of psychotropic medications during pregnancy must be balanced against those of untreated maternal mental illness, which has been under-appreciated as an exposure that impacts development.Methods: This is an expert, non-systematic literature review of the effect of maternal stress and psychotropic medication on fetal development.Results: Studies on the outcomes of pregnancy and child development following exposures to stress, mental disorders and psychotropic medications during pregnancy are reviewed. Alterations in pharmacokinetics due to the physiology of pregnancy may change the efficacy of drug treatment. The impact of stress and mental health conditions in pregnancy is difficult to separate from other exposures; however, these exposures have adverse effects on fetal and child development independent from medication treatment. A focus on optimal treatment to reduce psychiatric symptoms, which is the justification for use of the drug, is critical. Building healthy fetal brains through adequate maternal essential nutrient intake holds promise to support reduction of the risk for adverse neurodevelopmental outcomes.Conclusion: Untreated maternal mental illness is an exposure that impacts outcomes, the course of comorbid medical disorders, and offspring development. The current knowledge base dictates that treatment of psychiatric disorders be prioritized in the benefit-harm decision process.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152076"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When pregnancy termination fails: A tale of two teratogens: methotrexate and misoprostol - A narrative mini-review.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-26 DOI: 10.1016/j.semperi.2025.152078

Orna Diav-Citrin, Corinna Weber-Schoendorfer

引用次数: 0

Hemodynamics during noninvasive ventilation in neonates.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-10 DOI: 10.1016/j.semperi.2025.152065

Vidhi Jhaveri, Satyan Lakshminrusimha, Yogen Singh

{"title":"Hemodynamics during noninvasive ventilation in neonates.","authors":"Vidhi Jhaveri, Satyan Lakshminrusimha, Yogen Singh","doi":"10.1016/j.semperi.2025.152065","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152065","url":null,"abstract":"Noninvasive ventilation (NIV) is increasingly used in neonatal care to reduce lung injury and improve respiratory outcomes. However, its effects on cardiovascular function and cardiopulmonary interactions, particularly in preterm neonates, remain unclear. This paper reviews the hemodynamic changes associated with NIV and provides an overview of how NIV influences cardiac preload, pulmonary vascular resistance, ventricular output, and systemic blood flow. NIV also affects these parameters in different ways in neonates with compromised cardiovascular stability, such as those with persistent pulmonary hypertension, patent ductus arteriosus and systemic hypotension. The synthesis of current evidence underscores that optimizing NIV requires careful titration of ventilatory parameters and highlights the potential role of targeted echocardiography and other clinical monitoring tools in guiding individualized management strategies. This review emphasizes the need for a nuanced approach that balances respiratory support with hemodynamic stability and calls for further research to establish best practices for the safe and effective use of NIV in neonates with hemodynamic compromise.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152065"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of non-invasive ventilation on Bronchopulmonary Dysplasia.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-07 DOI: 10.1016/j.semperi.2025.152061

Vikramaditya Dumpa, Indirapriya Avulakunta, Vineet Bhandari

{"title":"Effect of non-invasive ventilation on Bronchopulmonary Dysplasia.","authors":"Vikramaditya Dumpa, Indirapriya Avulakunta, Vineet Bhandari","doi":"10.1016/j.semperi.2025.152061","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152061","url":null,"abstract":"Bronchopulmonary dysplasia (BPD) is a major complication of prematurity, leading to long-term pulmonary morbidity. Invasive mechanical ventilation (IMV) is associated with ventilator-induced lung injury, oxygen toxicity, and inflammation, all contributing to BPD pathogenesis. Non-invasive ventilation (NIV) has emerged as a key strategy to reduce the incidence and severity of BPD. We examine the role of various NIV strategies in the respiratory management of premature infants. We discuss the common forms of NIV, including nasal continuous positive airway pressure, nasal intermittent positive pressure ventilation, bilevel positive airway pressure, high-flow nasal cannula, and nasal high-frequency ventilation, with a focus on their mechanisms of action, benefits, and limitations. Several studies have demonstrated that early and appropriate NIV use can reduce the incidence of BPD, improve oxygenation, and promote lung growth. However, NIV is not without challenges, including patient selection, the timing of initiation, and potential difficulties in achieving adequate ventilation, especially in extremely low birth weight neonates. Adjunctive therapies such as early surfactant therapy, less invasive surfactant administration, and caffeine may enhance the effectiveness of NIV. In conclusion, NIV is a promising approach to decreasing BPD, yet its effectiveness relies on proper clinical application and integration with other therapies to maximize its benefits.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152061"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in management of noninvasive ventilation for preterm infants.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-06 DOI: 10.1016/j.semperi.2025.152060

Manoj Biniwale, Rangasamy Ramanathan

{"title":"Advances in management of noninvasive ventilation for preterm infants.","authors":"Manoj Biniwale, Rangasamy Ramanathan","doi":"10.1016/j.semperi.2025.152060","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152060","url":null,"abstract":"Providing most appropriate noninvasive ventilation (NIV) for preterm infants remains priority in neonatal intensive care units. Several newer modes of ventilation have evolved including continuous positive airway pressure, nasal intermittent positive pressure ventilation and noninvasive high frequency ventilation to meet patients' demands. Advanced level of monitoring is performed while patients are receiving NIV for optimization of the respiratory support. Point of care lung ultrasound and electrical impedance tomography are the newer tools that give insights towards aeration of the lungs. Pulmonary near infrared spectroscopy, electromyography of the diaphragm and advanced techniques of noninvasive pulmonary function testing provide data focusing on the performance of lungs. The hybrid modalities of ventilators used often in adults are needed in neonates to provide on demand individualized level of noninvasive respiratory support. Automated oxygen adjustment, inhaled nitric oxide and heliox can be benefcial when successfully provided through NIV. Delivery room NIV has a strong potential to improve neonatal outcomes. Further research should be focused taking into consideration physiologic needs and applying customized approach to meet patient's demands. Artificial intelligence leading to precision treatment is the way forward for providing individualized respiratory support for newborn infants.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152060"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIPPV vs CPAP: Lessons from meta-analyses.

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-06 DOI: 10.1016/j.semperi.2025.152062

Marc-Olivier Deguise, Brigitte Lemyre

{"title":"NIPPV vs CPAP: Lessons from meta-analyses.","authors":"Marc-Olivier Deguise, Brigitte Lemyre","doi":"10.1016/j.semperi.2025.152062","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152062","url":null,"abstract":"Care of the extremely premature infant has been in constant state of re-evaluation as the population, technologies and knowledge continue to evolve. A growing population of extremely low gestational age neonates (ELGAN - <28 weeks) and \"nanopremies\" (<24 weeks) are undergoing successful resuscitation, stabilization, and intensive care leading to improved survival. Respiratory care is the cornerstone of ELGAN management, as their lungs are at a critical stage of development. The lifesaving intensive care they require can lead to various injurious stimuli making them prone to bronchopulmonary dysplasia (BPD). Non-invasive ventilation (NIV), including continuous positive airway pressure ventilation (CPAP) and nasal intermittent positive pressure ventilation (NIPPV) has evolved and can appropriately support premature infants' breathing, while limiting the invasiveness and associated complications of mechanical ventilation. This review focuses on our current understanding, knowledge and evidence gathered via meta-analysis on these two modes of NIV in preterm infants, when used either as primary intent respiratory support post-birth or following extubation. We will summarize the current data of recent meta-analyses, their pitfalls, and the remaining questions to be addressed by future research to optimize the use of these modes of respiratory support in preterm infants most at risk for BPD.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152062"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma in pregnancy

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-03-01 DOI: 10.1016/j.semperi.2025.152040

Christina S. Oh , Elizabeth F. Sher , Amy K. Bieber

引用次数: 0