Seminars in perinatology最新文献_第2页

Perception of neonatal outcomes: lessons learned from positive health. 对新生儿结局的认识：从积极健康中吸取的教训。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-22 DOI: 10.1016/j.semperi.2025.152156

Mary Lauren Neel, Kristen L Benninger

引用次数: 0

Gastroesophageal reflux and apnea in the preterm infant. 早产儿胃食管反流与呼吸暂停

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-22 DOI: 10.1016/j.semperi.2025.152151

Eric C Eichenwald

引用次数: 0

Genetic epilepsies as a cause of seizures in Neonates. 遗传性癫痫是新生儿癫痫发作的一个原因。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-19 DOI: 10.1016/j.semperi.2025.152146

Adam L Numis, Marie-Coralie Cornet, Hannah C Glass

{"title":"Genetic epilepsies as a cause of seizures in Neonates.","authors":"Adam L Numis, Marie-Coralie Cornet, Hannah C Glass","doi":"10.1016/j.semperi.2025.152146","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152146","url":null,"abstract":"The objective of this review is to summarize current knowledge on epilepsies presenting in the neonatal period and to highlight their implications for diagnosis and treatment. While most seizures in newborns are due to acute brain injuries, a significant minority are caused by genetic epilepsies, which require distinct clinical management. Advances in genetic testing have clarified the major etiologic categories, including channelopathies, synaptopathies, inborn errors of metabolism, and brain malformations. Bedside clinicians must be alert to a possible genetic epilepsy in a newborn with seizures, as precise diagnosis informs prognosis and directly guides therapy. Sodium channel blockers can improve seizure control in specific channelopathies, vitamin therapies are effective in certain metabolic epilepsies, dietary therapy is transformative in glucose transporter deficiency syndrome, and targeted approaches are emerging for tuberous sclerosis complex. Rapid exome and genome sequencing now enable timely diagnosis in critically ill neonates and support precision treatment. Even with improvements in seizure control, developmental outcomes often remain poor, underscoring the urgent need for disease-modifying therapies. In conclusion, early recognition of epilepsies in the neonatal intensive care unit is essential to optimize care today and to accelerate the development of future targeted treatments.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152146"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving outcomes for preterm infants: Mitigating stress exposure. 改善早产儿的预后：减轻压力暴露。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-19 DOI: 10.1016/j.semperi.2025.152153

Marliese Dion Nist, Nicole Cistone, Rita H Pickler

{"title":"Improving outcomes for preterm infants: Mitigating stress exposure.","authors":"Marliese Dion Nist, Nicole Cistone, Rita H Pickler","doi":"10.1016/j.semperi.2025.152153","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152153","url":null,"abstract":"Stress exposure in the neonatal intensive care unit (NICU) is ubiquitous and affects long-term outcomes for preterm infants. The NICU hospitalization occurs during a critical period of experience-dependent and experience-expectant development when the immature brain is particularly sensitive to environmental exposures, but the experiences of preterm infants are often poorly matched to their neurologic expectations. The mismatch between preterm infants' experiences and neurologic expectations may cause abnormal brain development and programming of the stress response systems. Routine nursing care and parental separation are two neurologically unexpected experiences that, while often overlooked, may be amenable to interventions, including system-level changes. To guide the development and implementation of effective interventions, it is necessary to understand how nurse caregiving practices and parental separation specifically contribute to the preterm infant's stress burden. The purpose of this paper is to provide an overview of the effects of routine nursing care and parental separation, two persistent NICU stressors, and offer recommendations for interventions that nurses and other care providers can use to mitigate the negative effects of these exposures.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152153"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interdisciplinary collaboration and innovation in established bronchopulmonary dysplasia. 支气管肺发育不良的跨学科合作与创新。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-18 DOI: 10.1016/j.semperi.2025.152148

Matthew J Kielt, Lauren A Sanlorenzo

引用次数: 0

Preface. 前言。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-18 DOI: 10.1016/j.semperi.2025.152142

Kristen L Benninger, Mary Lauren Neel

引用次数: 0

Transforming neonatal care through informatics: A review of artificial intelligence, data, and implementation considerations. 通过信息学转变新生儿护理：人工智能，数据和实施考虑因素的回顾。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-18 DOI: 10.1016/j.semperi.2025.152144

Robert Barrett, Brooke Lawler, Star Liu, Woo Yeon Park, Marjan Davoodi, Ben Martin, Sai Manasa Kalyanam, Kartikeya Makker, Jordan R Kuiper, Khyzer B Aziz

{"title":"Transforming neonatal care through informatics: A review of artificial intelligence, data, and implementation considerations.","authors":"Robert Barrett, Brooke Lawler, Star Liu, Woo Yeon Park, Marjan Davoodi, Ben Martin, Sai Manasa Kalyanam, Kartikeya Makker, Jordan R Kuiper, Khyzer B Aziz","doi":"10.1016/j.semperi.2025.152144","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152144","url":null,"abstract":"Significant strides have been made in utilizing data, information, and knowledge to enhance neonatal outcomes. This review examines how data informatics, encompassing electronic health records (EHRs), data standards, and artificial intelligence (AI), has facilitated advancements in neonatal care and research. Vast amounts of data, structured and unstructured, have been produced from clinical care. In turn AI stands to improve patient care, safety, and quality improvement initiatives. Facilitated by AI, clinicians' interaction with neonatal informatic tools is transitioning from reactive to real-time, proactive care. Historically, necrotizing enterocolitis, sepsis, medical imaging, and neonatal mortality have been the targets of AI-integrated neonatal care. While much progress has been made in developing state-of-the-art AI tools, their development and implementation must consider optimization of patient care, clinical workflows, and aim to decrease clinician burnout. Employing a sociotechnical framework to assess both technical and human factors is key to effectively evaluating clinical utility, promoting adoption, and facilitating successful deployment. Beyond technical concerns, ethical considerations such as trust in AI, data security, and model transparency are critical to the responsible deployment of informatics tools. Ongoing advancements in neonatal care coupled with informatics, multi-omics, AI, and federated learning expands the possibilities of personalized care for neonates.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152144"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending the Branches of Neonatal Neurocritical Care. 扩展新生儿神经危重症护理的分支。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-18 DOI: 10.1016/j.semperi.2025.152131

Mark A Petersen, Hannah C Glass

{"title":"Extending the Branches of Neonatal Neurocritical Care.","authors":"Mark A Petersen, Hannah C Glass","doi":"10.1016/j.semperi.2025.152131","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152131","url":null,"abstract":"Neonatal Neurocritical Care (NNCC) is transforming neonatal medicine through a brain-centered approach that reflects the complexity and rapid progression of early neurodevelopment. NNCC provides a comprehensive care model built on a foundation of real-time neuromonitoring, advanced neuroimaging, and multidisciplinary collaboration to deliver timely neurological support for newborns at risk of injury. This framework has evolved to bridge the full arc of early brain development, linking fetal evaluation, neonatal management, and post-discharge follow-up into a cohesive continuum. Recent technological advances in bedside monitoring, functional neuroimaging, machine learning, and rapid genomics are shifting NNCC toward a more proactive and personalized model of care. Emerging therapies are also expanding the clinical reach of NNCC, opening new frontiers for early intervention and neurorepair. As the field continues to advance, the central goal of NNCC remains to improve neurodevelopmental outcomes while ensuring widespread access to high-quality, family-centered neurological care. This review outlines the evolving landscape of NNCC and highlights its essential role in guiding brain-focused care from the earliest stages of development through childhood and beyond.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152131"},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of cerebral palsy in community settings: current state and a pathway forward. 在社区环境中早期发现脑瘫：现状和未来的途径。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-13 DOI: 10.1016/j.semperi.2025.152147

Nathalie L Maitre, Kaniska S Baduni

{"title":"Early detection of cerebral palsy in community settings: current state and a pathway forward.","authors":"Nathalie L Maitre, Kaniska S Baduni","doi":"10.1016/j.semperi.2025.152147","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152147","url":null,"abstract":"We explore how and why early detection of cerebral palsy (CP) should occur in community settings across low and middle income countries (LMICs) and high income countries (HICs). Early diagnosis is best clinical practice and can happen in the first year of life using evidence-based tools such as the General Movements Assessment (GMA) and the Hammersmith Infant Neurological Examination (HINE). In HICs, primary care surveillance guided by published motor \"red flags\" can identify children who need prompt referral, yet uptake remains uneven. In LMICs, clinicians demonstrate high diagnostic accuracy when tools are available, but the main barrier is health system reach rather than clinical capability. Across settings, caregiver studies show that delayed diagnosis reduces empowerment, increases mental health burden, and erodes trust in services. The central implementation task is to build reliable pathways that connect families from home to timely diagnosis, aligning community surveillance with referral networks, provider training, and policy support. Strengthening these pathways is essential to improve participation, reduce comorbidity burden, and enhance wellbeing for children with CP and their families.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152147"},"PeriodicalIF":3.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The placenta as a window into neonatal brain injury. 胎盘是新生儿脑损伤的一个窗口。

IF 3.2 3区医学

Seminars in perinatology Pub Date : 2025-09-13 DOI: 10.1016/j.semperi.2025.152143

Elmira Bachinsky, Lauren Guyer, Riddhi Patel, Stephen K Amoah, Diana Ortega, Shenandoah Robinson, Hawley Helmbrecht, Lauren L Jantzie

{"title":"The placenta as a window into neonatal brain injury.","authors":"Elmira Bachinsky, Lauren Guyer, Riddhi Patel, Stephen K Amoah, Diana Ortega, Shenandoah Robinson, Hawley Helmbrecht, Lauren L Jantzie","doi":"10.1016/j.semperi.2025.152143","DOIUrl":"10.1016/j.semperi.2025.152143","url":null,"abstract":"The placenta serves as an essential communicative organ between a mother and fetus throughout gestation. The placenta is critical in the development and maintenance of pregnancy while serving as a hub for immune signaling. In the context of an ever-changing microenvironment, the placenta responds dynamically to infection, inflammation, and other potentially harmful exposures. As in chorioamnionitis and preterm birth, a placental inflammatory response can impart harm to the developing fetal brain and facilitate the presentation of perinatal brain injury. Through various functional and structural disruptions, including changes to neural networks and complex neural immune interactions, neurodevelopmental disorders can manifest. In this review, we utilize chorioamnionitis as a platform for understanding immune signaling and inflammatory cell communication along the maternal-placental-fetal axis. We delineate how immune dysfunction changes neurodevelopment and explore cellular and molecular mechanisms associated with adverse clinical outcomes after birth. Together with discussion of unique inflammatory pathophysiology and triggers of perinatal brain injury, we explore avenues for neuroimmunomodulation, novel biomarker discovery, and precision medicine approaches for clinical practice.","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152143"},"PeriodicalIF":3.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0