{"title":"The history of neonatal abstinence syndrome","authors":"Prabhakar Kocherlakota","doi":"10.1016/j.semperi.2024.152007","DOIUrl":"10.1016/j.semperi.2024.152007","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152007"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The evolution of teratology: Historical perspectives and lessons learned.","authors":"Sarah Običan, Nevena Krstić","doi":"10.1016/j.semperi.2025.152025","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152025","url":null,"abstract":"<p><p>Teratology, the study of congenital anomalies caused by environmental, chemical, and biological factors, derives from the Greek \"teratos,\" meaning monster, reflecting historical intrigue with birth defects. While the field is relatively modern, curiosity about anomalies spans millennia, as seen in ancient art and mythology. Over time, societal views shifted from curiosity to fear, recognizing birth defects as potential social, economic, and spiritual burdens. The 20th century brought pivotal advances. Discoveries such as the rubella-birth defect link, ionizing radiation effects, and the thalidomide disaster reshaped understanding and regulations. Wilson's \"Six Principles of Teratology\" established guidelines for how teratogens impact development, focusing on timing, dose-response relationships, and genetic susceptibility. Despite progress, birth defects still affect millions worldwide, underscoring the importance of education and counseling on teratogenic risks. Resources like TERIS, Reprotox, and MotherToBaby now provide healthcare professionals with evidence-based guidance, aiding informed decision-making and improving pregnancy outcomes. The ever-evolving field of teratology emphasizes the need for ongoing research and effective communication to manage and prevent birth defects.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152025"},"PeriodicalIF":3.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physiological basis of non-invasive ventilation in the newborn.","authors":"Theodore Dassios","doi":"10.1016/j.semperi.2024.152023","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.152023","url":null,"abstract":"<p><p>Non-invasive ventilation (NIV) is a form of respiratory support provided primarily to preterm born infants in an effort to avoid any endotracheal intubation or as a weaning step following invasive ventilation. In the context of the respiratory distress syndrome of the newborn, NIV could target and partially reverse specific pathophysiological phenomena, by improving alveolar recruitment and establishing adequate functional residual capacity. It can also assist in minimizing lung injury by avoiding excessive pressure delivery, which can be harmful for the developing lung. Non-invasive ventilation can unload the respiratory muscles and decrease the work of breathing as reported by studies that compare the measured work of breathing at increasing levels of non-invasive support. NIV can also be beneficial in moderating the frequency and intensity of apnea of prematurity. Unintended physiological effects of NIV include gaseous distension of the gastrointestinal tract and increased incidence of air-leak complications. During NIV there is also a lack of direct access to the trachea for suctioning and pulmonary toiletry. Insufficient non-invasive respiratory support could be associated with inadequate oxygenation and ventilation, insufficient gas exchange and atelectotrauma. Excessive provision of non-invasive support could be inefficient or harmful, as overdistention can be associated with decreased compliance of the respiratory system, impaired gas exchange and abnormal diaphragmatic function. An individualized physiological approach could, thus, aim to optimize the beneficial effects of non-invasive ventilation while avoiding inadequate or excessive levels of support.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152023"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Haggerty , Monika Bajaj , Girija Natarajan , Anne Ades
{"title":"Post-resuscitation care in the NICU","authors":"Mary Haggerty , Monika Bajaj , Girija Natarajan , Anne Ades","doi":"10.1016/j.semperi.2024.151993","DOIUrl":"10.1016/j.semperi.2024.151993","url":null,"abstract":"<div><div>Post-cardiac arrest syndrome is a unique pathophysiologic condition that is well-described in adult and pediatric populations. Early, goal-directed care after cardiac arrest can mitigate ongoing injury, improve clinical outcomes, and prevent re-arrest. There is a paucity of evidence about post-cardiac arrest care in the NICU, however, pediatric principles and guidelines can be applied in the NICU in the appropriate clinical context.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151993"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharada Gowda , Molly K Ball , Satyan Lakshminrusimha , Danielle R Rios , Patrick J McNamara
{"title":"Hemodynamic instability in the transitional period after birth","authors":"Sharada Gowda , Molly K Ball , Satyan Lakshminrusimha , Danielle R Rios , Patrick J McNamara","doi":"10.1016/j.semperi.2024.151986","DOIUrl":"10.1016/j.semperi.2024.151986","url":null,"abstract":"<div><div>It is not uncommon for a patient to experience hemodynamic instability following birth. This is due to the fact that the transitional period requires dramatic cardiorespiratory changes. When it goes well, improved lung compliance and successful transition to the postnatal circulation is seen. However, it is highly beneficial that clinicians have a solid understanding of all of the required changes, the unique aspects of the neonatal myocardium, and the influence of cardiovascular disease on normal adaptive mechanisms. In this manuscript, we will review the physiology of the normal postnatal circulatory adaptation, the unique characteristics of the neonatal myocardium and how it behaves in states of altered loading conditions, and the impact of hemodynamic disease states on health and wellbeing during the immediate postnatal time-period.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151986"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beth Ann Johnson , Jennifer Shepherd , Shazia Bhombal , Noorjahan Ali , Chloe Joynt
{"title":"Special considerations for the stabilization and resuscitation of patients with cardiac disease in the Neonatal Intensive Care Unit","authors":"Beth Ann Johnson , Jennifer Shepherd , Shazia Bhombal , Noorjahan Ali , Chloe Joynt","doi":"10.1016/j.semperi.2024.151989","DOIUrl":"10.1016/j.semperi.2024.151989","url":null,"abstract":"<div><div>Effective resuscitation of neonates with congenital heart disease (CHD) depends on comprehensive planning, thorough understanding of physiology, vigilant monitoring, and interdisciplinary collaboration to achieve the best outcomes. Neonatal heart disease can affect cardiac structure, rhythm, or ventricular function, and may be either congenital or acquired. Critical congenital heart disease (CCHD) can result in inadequate pulmonary blood flow, impaired intracardiac mixing, airway obstruction, or insufficient cardiac output. Tailored resuscitation strategies are important as early as the delivery room, where some CHD lesions may cause immediate cardiovascular instability during the transition from fetal to postnatal circulation. Premature infants with CHD are at higher risk due to their small size and the complications associated with prematurity, affecting both CHD management and overall clinical stability. Addressing both cardiac and non-cardiac causes of decompensation requires a precise understanding of each patient's unique physiology and trajectory from delivery through postintervention intensive care.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151989"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jihye Kim Scroggins , Sarah E. Harkins , Sevonna Brown , Victoria St. Clair , Guramrit K. LeBron , Veronica Barcelona
{"title":"Corrigendum to “A systematic review of community-based interventions to address perinatal mental health” [Seminars in Perinatology, 48(6), 2024, 151945]","authors":"Jihye Kim Scroggins , Sarah E. Harkins , Sevonna Brown , Victoria St. Clair , Guramrit K. LeBron , Veronica Barcelona","doi":"10.1053/j.semperi.2024.151994","DOIUrl":"10.1053/j.semperi.2024.151994","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151994"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regine M Fortunov , Erwin Cabacungan , James S Barry , Jawahar Jagarapu
{"title":"Artificial intelligence and informatics in neonatal resuscitation","authors":"Regine M Fortunov , Erwin Cabacungan , James S Barry , Jawahar Jagarapu","doi":"10.1016/j.semperi.2024.151992","DOIUrl":"10.1016/j.semperi.2024.151992","url":null,"abstract":"<div><div>Neonatal intensive care unit resuscitative care continually evolves and increasingly relies on data. Data driven precision resuscitation care can be enabled by leveraging informatics tools and artificial intelligence. Despite technological advancements, these data are often underutilized due to suboptimal data capture, aggregation, and low adoption of artificial intelligence and analytic tools. This review describes the fundamentals and explores the evidence behind informatics and artificial intelligence tools supporting neonatal intensive care unit resuscitative care, training and education. Key findings include the need for effective interface design for accurate data capture followed by storage and translation to wisdom using analytics and artificial intelligence tools. This review addresses the issues of data privacy, bias, liability and ethical frameworks when adopting these tools. While these emerging technologies hold great promise to improve resuscitation, further study of these applications in neonatal population and awareness of informatics and artificial intelligence principles among clinicians is imperative.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151992"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Summer Elshenawy , Monique R. Radman-Harrison , Philip T. Levy , Satyan Lakshminrusimha , Taylor L. Sawyer , Brenda H. Law
{"title":"Principles of resuscitation for infants with severe bronchopulmonary dysplasia","authors":"Summer Elshenawy , Monique R. Radman-Harrison , Philip T. Levy , Satyan Lakshminrusimha , Taylor L. Sawyer , Brenda H. Law","doi":"10.1016/j.semperi.2024.151990","DOIUrl":"10.1016/j.semperi.2024.151990","url":null,"abstract":"<div><div>Severe bronchopulmonary dysplasia (sBPD) requiring invasive mechanical ventilation is a heterogeneous disease process that contributes to morbidity and mortality in infants. As the most common lung disease of prematurity, sBPD has a multitude of overlapping cardiac, airway, pulmonary vascular, and infectious phenotypic presentations that progress through four different phases of care. Premature infants with sBPD are at a high risk of acute decompensation and subsequent cardiopulmonary arrest. A comprehensive determination of the complex phenotypes that contribute to the clinical presentation will help clinicians decipher the phase of care, identify cardiopulmonary compromise earlier and guide targeted therapeutic intervention during acute episodes of deterioration. The approach to resuscitation of premature infants with sBPD undergoing an acute decompensation differs from general neonatal and pediatric resuscitation practices. This review summarizes the phenotypes of sBPD, the phases of care, the common triggers of acute exacerbations, and the principles of resuscitation of a deteriorating infant with sBPD. We offer a framework for sBPD resuscitation with a focus on prevention, assessment, and post-resuscitative care.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151990"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruby Gupta , Swosti Joshi , Asya Asghar , Megan M. Gray
{"title":"Metabolic emergencies in the NICU","authors":"Ruby Gupta , Swosti Joshi , Asya Asghar , Megan M. Gray","doi":"10.1016/j.semperi.2024.151987","DOIUrl":"10.1016/j.semperi.2024.151987","url":null,"abstract":"<div><div>Metabolic emergencies in neonates can present with nonspecific signs and symptoms. Sudden acute deterioration in a neonate should prompt consideration of metabolic disease. Common metabolic emergencies in the Neonatal Intensive Care Unit (NICU) include hypoglycemia, hyperammonemia, hyperbilirubinemia, metabolic acidosis, adrenal insufficiency, and electrolyte imbalances. These emergencies often require prompt recognition and intervention to prevent serious complications. Appropriate management depends on the diagnosis. However, initial resuscitation and stabilization can be started without a definitive diagnosis. Confirmatory testing and long-term management vary by condition and should be guided by symptoms and endocrinologist input.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151987"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}