{"title":"Hospital sequelae, discharge, and early interventions in infants with Neonatal Opioid Withdrawal Syndrome","authors":"Frances Y. Cheng","doi":"10.1016/j.semperi.2024.152008","DOIUrl":"10.1016/j.semperi.2024.152008","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152008"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pre-natal and post-natal screening and testing in neonatal abstinence syndrome","authors":"Sharon Ostfeld-Johns","doi":"10.1016/j.semperi.2024.152009","DOIUrl":"10.1016/j.semperi.2024.152009","url":null,"abstract":"<div><div>The way we enact screening for substance use during pregnancy within our healthcare systems can work by decreasing stigma, promoting engagement, and supporting people with reaching the end of their pregnancy in a manner where the newborn can be well supported. The way we enact biochemical specimen toxicology testing for substance use during pregnancy and in newborns contributes to increased stigma, disengagement from care, and potential continuation of uncontrolled substance use up until delivery such that the newborn may not be able to be well supported in the family environment. These effects are inequitably distributed, leading to worse outcomes for families of color and families living in poverty. Serial screening with a validated questionnaire starting at the first prenatal visit and continuing through the delivery hospitalization should occur and be followed up with service connections and substance use disorder diagnosis and treatment. Newborn toxicology testing as a diagnostic tool for risk of withdrawal or the etiology of potential withdrawal symptoms represents a failure in the effectiveness of compassionate communication by healthcare providers with the birthing person. Given the current level of evidence of clinical utility and the inequitable consequences specific to these tests, they are rarely needed.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152009"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of parent and healthcare provider experiences based on approach to managing Neonatal Opioid Withdrawal Syndrome (NOWS)","authors":"Lisa M. Cleveland","doi":"10.1016/j.semperi.2024.151995","DOIUrl":"10.1016/j.semperi.2024.151995","url":null,"abstract":"<div><div>Neonatal Opioid Withdrawal Syndrome (NOWS) is a group of clinical withdrawal signs occurring in prenatally opioid-exposed newborns and manifesting as neurobehavioral dysregulation, including extreme irritability such as excessive crying, rigid muscle tone, and difficulty feeding and sleeping. One U.S. infant experiencing NOWS is born every 25 min. Clinical management of these infants has traditionally occurred in the high-acuity environment of a neonatal intensive care unit (NICU), which contributes to separation of infants from their parents and increases the likelihood of pharmacological intervention to manage withdrawal. Over the past decade, more holistic approaches, such as the Eat, Sleep, and Console method, have focused on parents’ active participation in care, rooming-in, and implementation of non-pharmacologic soothing techniques to reduce medication use, hospital length of stay, and healthcare expenditures. These distinctly different management approaches have contributed to unique experiences for parents and healthcare providers involved in infants’ care; therefore, the purpose of this paper is to review the experiences of parents and healthcare providers as they relate to management approaches for infants with NOWS.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 151995"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kia Johnson, Adam Berkwitt, Lyubina Yankova, Rachel Osborn
{"title":"Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach","authors":"Kia Johnson, Adam Berkwitt, Lyubina Yankova, Rachel Osborn","doi":"10.1016/j.semperi.2024.152021","DOIUrl":"10.1016/j.semperi.2024.152021","url":null,"abstract":"<div><div>Increased incidence of Neonatal Opioid Withdrawal Syndrome has prompted innovation in assessment and management approaches. The Finnegan Approach and the Eat, Sleep, Console are the two most commonly described approaches, though they differ substantially. The goals of this review article are to describe and compare these approaches and published outcomes, including areas of uncertainty that may inform future directions.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152021"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erinma P. Ukoha (Assistant Professor) , Mishka Terplan (Medical Director)
{"title":"Treatment and decriminalization of the mother-infant dyad in perinatal opioid use disorder","authors":"Erinma P. Ukoha (Assistant Professor) , Mishka Terplan (Medical Director)","doi":"10.1016/j.semperi.2024.152005","DOIUrl":"10.1016/j.semperi.2024.152005","url":null,"abstract":"<div><div>Treatment of perinatal opioid use disorder should center the mother-infant dyad, the needs of both entities, and preservation of the relationship. The criminalization of pregnancy and substance use in pregnancy through punitive policies and legislation and the involvement of the family policing system are in direct opposition to compassionate, person-centered care and lead to worse maternal and neonatal outcomes. In this chapter, we review the history and ongoing criminalization of pregnancy and perinatal substance use disorder, explore carcerality as a barrier to dyadic care that disproportionately targets Black, Brown, and Indigenous birthing individuals, and propose solutions to decriminalize care based in abolition medicine and reproductive justice frameworks.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152005"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The history of neonatal abstinence syndrome","authors":"Prabhakar Kocherlakota","doi":"10.1016/j.semperi.2024.152007","DOIUrl":"10.1016/j.semperi.2024.152007","url":null,"abstract":"","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"49 1","pages":"Article 152007"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The evolution of teratology: Historical perspectives and lessons learned.","authors":"Sarah Običan, Nevena Krstić","doi":"10.1016/j.semperi.2025.152025","DOIUrl":"https://doi.org/10.1016/j.semperi.2025.152025","url":null,"abstract":"<p><p>Teratology, the study of congenital anomalies caused by environmental, chemical, and biological factors, derives from the Greek \"teratos,\" meaning monster, reflecting historical intrigue with birth defects. While the field is relatively modern, curiosity about anomalies spans millennia, as seen in ancient art and mythology. Over time, societal views shifted from curiosity to fear, recognizing birth defects as potential social, economic, and spiritual burdens. The 20th century brought pivotal advances. Discoveries such as the rubella-birth defect link, ionizing radiation effects, and the thalidomide disaster reshaped understanding and regulations. Wilson's \"Six Principles of Teratology\" established guidelines for how teratogens impact development, focusing on timing, dose-response relationships, and genetic susceptibility. Despite progress, birth defects still affect millions worldwide, underscoring the importance of education and counseling on teratogenic risks. Resources like TERIS, Reprotox, and MotherToBaby now provide healthcare professionals with evidence-based guidance, aiding informed decision-making and improving pregnancy outcomes. The ever-evolving field of teratology emphasizes the need for ongoing research and effective communication to manage and prevent birth defects.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152025"},"PeriodicalIF":3.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physiological basis of non-invasive ventilation in the newborn.","authors":"Theodore Dassios","doi":"10.1016/j.semperi.2024.152023","DOIUrl":"https://doi.org/10.1016/j.semperi.2024.152023","url":null,"abstract":"<p><p>Non-invasive ventilation (NIV) is a form of respiratory support provided primarily to preterm born infants in an effort to avoid any endotracheal intubation or as a weaning step following invasive ventilation. In the context of the respiratory distress syndrome of the newborn, NIV could target and partially reverse specific pathophysiological phenomena, by improving alveolar recruitment and establishing adequate functional residual capacity. It can also assist in minimizing lung injury by avoiding excessive pressure delivery, which can be harmful for the developing lung. Non-invasive ventilation can unload the respiratory muscles and decrease the work of breathing as reported by studies that compare the measured work of breathing at increasing levels of non-invasive support. NIV can also be beneficial in moderating the frequency and intensity of apnea of prematurity. Unintended physiological effects of NIV include gaseous distension of the gastrointestinal tract and increased incidence of air-leak complications. During NIV there is also a lack of direct access to the trachea for suctioning and pulmonary toiletry. Insufficient non-invasive respiratory support could be associated with inadequate oxygenation and ventilation, insufficient gas exchange and atelectotrauma. Excessive provision of non-invasive support could be inefficient or harmful, as overdistention can be associated with decreased compliance of the respiratory system, impaired gas exchange and abnormal diaphragmatic function. An individualized physiological approach could, thus, aim to optimize the beneficial effects of non-invasive ventilation while avoiding inadequate or excessive levels of support.</p>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":" ","pages":"152023"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Haggerty , Monika Bajaj , Girija Natarajan , Anne Ades
{"title":"Post-resuscitation care in the NICU","authors":"Mary Haggerty , Monika Bajaj , Girija Natarajan , Anne Ades","doi":"10.1016/j.semperi.2024.151993","DOIUrl":"10.1016/j.semperi.2024.151993","url":null,"abstract":"<div><div>Post-cardiac arrest syndrome is a unique pathophysiologic condition that is well-described in adult and pediatric populations. Early, goal-directed care after cardiac arrest can mitigate ongoing injury, improve clinical outcomes, and prevent re-arrest. There is a paucity of evidence about post-cardiac arrest care in the NICU, however, pediatric principles and guidelines can be applied in the NICU in the appropriate clinical context.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151993"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharada Gowda , Molly K Ball , Satyan Lakshminrusimha , Danielle R Rios , Patrick J McNamara
{"title":"Hemodynamic instability in the transitional period after birth","authors":"Sharada Gowda , Molly K Ball , Satyan Lakshminrusimha , Danielle R Rios , Patrick J McNamara","doi":"10.1016/j.semperi.2024.151986","DOIUrl":"10.1016/j.semperi.2024.151986","url":null,"abstract":"<div><div>It is not uncommon for a patient to experience hemodynamic instability following birth. This is due to the fact that the transitional period requires dramatic cardiorespiratory changes. When it goes well, improved lung compliance and successful transition to the postnatal circulation is seen. However, it is highly beneficial that clinicians have a solid understanding of all of the required changes, the unique aspects of the neonatal myocardium, and the influence of cardiovascular disease on normal adaptive mechanisms. In this manuscript, we will review the physiology of the normal postnatal circulatory adaptation, the unique characteristics of the neonatal myocardium and how it behaves in states of altered loading conditions, and the impact of hemodynamic disease states on health and wellbeing during the immediate postnatal time-period.</div></div>","PeriodicalId":21761,"journal":{"name":"Seminars in perinatology","volume":"48 8","pages":"Article 151986"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}