Seminars in Immunopathology最新文献_第4页

The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits. 成功的标志：疫苗诱导的皮肤疤痕形成对卡介苗和天花疫苗相关临床益处的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-26 DOI: 10.1007/s00281-024-01022-9

Ole Bæk, Frederik Schaltz-Buchholzer, Anita Campbell, Nelly Amenyogbe, James Campbell, Peter Aaby, Christine Stabell Benn, Tobias R Kollmann

引用次数: 0

Advances in manufacturing chimeric antigen receptor immune cell therapies. 制造嵌合抗原受体免疫细胞疗法的进展。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-16 DOI: 10.1007/s00281-024-01019-4

Apoorva Ramamurthy, Anna Tommasi, Krishanu Saha

{"title":"Advances in manufacturing chimeric antigen receptor immune cell therapies.","authors":"Apoorva Ramamurthy, Anna Tommasi, Krishanu Saha","doi":"10.1007/s00281-024-01019-4","DOIUrl":"10.1007/s00281-024-01019-4","url":null,"abstract":"Biomedical research has witnessed significant strides in manufacturing chimeric antigen receptor T cell (CAR-T) therapies, marking a transformative era in cellular immunotherapy. Nevertheless, existing manufacturing methods for autologous cell therapies still pose several challenges related to cost, immune cell source, safety risks, and scalability. These challenges have motivated recent efforts to optimize process development and manufacturing for cell therapies using automated closed-system bioreactors and models created using artificial intelligence. Simultaneously, non-viral gene transfer methods like mRNA, CRISPR genome editing, and transposons are being applied to engineer T cells and other immune cells like macrophages and natural killer cells. Alternative sources of primary immune cells and stem cells are being developed to generate universal, allogeneic therapies, signaling a shift away from the current autologous paradigm. These multifaceted innovations in manufacturing underscore a collective effort to propel this therapeutic approach toward broader clinical adoption and improved patient outcomes in the evolving landscape of cancer treatment. Here, we review current CAR immune cell manufacturing strategies and highlight recent advancements in cell therapy scale-up, automation, process development, and engineering.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 5","pages":"12"},"PeriodicalIF":7.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond defence: Immune architects of ovarian health and disease. 超越防御：卵巢健康与疾病的免疫建筑师。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-12 DOI: 10.1007/s00281-024-01021-w

Maria Victoria Bazzano, Angela Köninger, Maria Emilia Solano

{"title":"Beyond defence: Immune architects of ovarian health and disease.","authors":"Maria Victoria Bazzano, Angela Köninger, Maria Emilia Solano","doi":"10.1007/s00281-024-01021-w","DOIUrl":"10.1007/s00281-024-01021-w","url":null,"abstract":"Throughout the individual's reproductive period of life the ovary undergoes continues changes, including cyclic processes of cell death, tissue regeneration, proliferation, and vascularization. Tissue-resident leucocytes particularly macrophages, play a crucial role in shaping ovarian function and maintaining homeostasis. Macrophages crucially promote angiogenesis in the follicles and corpora lutea, thereby supporting steroidogenesis. Recent research on macrophage origins and early tissue seeding has unveiled significant insights into their role in early organogenesis, e.g. in the testis. Here, we review evidence about the prenatal ovarian seeding of leucocytes, primarily macrophages with angiogenic profiles, and its connection to gametogenesis. In the prenatal ovary, germ cells proliferate, form cysts, and undergo changes that, following waves of apoptosis, give rice to the oocytes contained in primordial follicles. These follicles constitute the ovarian reserve that lasts throughout the female's reproductive life. Simultaneously, yolk-sac-derived primitive macrophages colonizing the early ovary are gradually replaced or outnumbered by monocyte-derived fetal macrophages. However, the cues indicating how macrophage colonization and follicle assembly are related are elusive. Macrophages may contribute to organogenesis by promoting early vasculogenesis. Whether macrophages contribute to ovarian lymphangiogenesis or innervation is still unknown. Ovarian organogenesis and gametogenesis are vulnerable to prenatal insults, potentially programming dysfunction in later life, as observed in polycystic ovary syndrome. Experimental and, more sparsely, epidemiological evidence suggest that adverse stimuli during pregnancy can program defective folliculogenesis or a diminished follicle reserve in the offspring. While the ovary is highly sensitive to inflammation, the involvement of local immune responses in programming ovarian health and disease remains to be thoroughly investigated.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 3-4","pages":"11"},"PeriodicalIF":7.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases. DNA 损伤反应和细胞衰老之间的相互影响是衰老和老年相关疾病的驱动因素。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-02 DOI: 10.1007/s00281-024-01016-7

Ajmal Ahmad, Anneliesse Braden, Sazzad Khan, Jianfeng Xiao, Mohammad Moshahid Khan

{"title":"Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases.","authors":"Ajmal Ahmad, Anneliesse Braden, Sazzad Khan, Jianfeng Xiao, Mohammad Moshahid Khan","doi":"10.1007/s00281-024-01016-7","DOIUrl":"10.1007/s00281-024-01016-7","url":null,"abstract":"Cellular senescence is a crucial process of irreversible cell-cycle arrest, in which cells remain alive, but permanently unable to proliferate in response to distinct types of stressors. Accumulating evidence suggests that DNA damage builds over time and triggers DNA damage response signaling, leading to cellular senescence. Cellular senescence serves as a platform for the perpetuation of inflammatory responses and is central to numerous age-related diseases. Defects in DNA repair genes or senescence can cause premature aging disease. Therapeutic approaches limiting DNA damage or senescence contribute to a rescued phenotype of longevity and neuroprotection, thus suggesting a mechanistic interaction between DNA damage and senescence. Here, we offer a unique perspective on the crosstalk between the DNA damage response pathway and senescence as well as their contribution to age-related diseases. We further summarize recent progress on the mechanisms and therapeutics of senescence, address existing challenges, and offering new insights and future directions in the senescence field.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 3-4","pages":"10"},"PeriodicalIF":7.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life risk factors which govern pro-allergic immunity 影响抗过敏免疫力的早期生活风险因素

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-27 DOI: 10.1007/s00281-024-01020-x

Catherine Ptaschinski, Bernhard F. Gibbs

{"title":"Early-life risk factors which govern pro-allergic immunity","authors":"Catherine Ptaschinski, Bernhard F. Gibbs","doi":"10.1007/s00281-024-01020-x","DOIUrl":"https://doi.org/10.1007/s00281-024-01020-x","url":null,"abstract":"Allergic diseases affect up to 40% of the global population with a substantial rise in food allergies, in particular, over the past decades. For the majority of individuals with allergy fundamental programming of a pro-allergic immune system largely occurs in early childhood where it is crucially governed by prenatal genetic and environmental factors, including their interactions. These factors include several genetic aberrations, such as filaggrin loss-of-function mutations, early exposure to respiratory syncytial virus, and various chemicals such as plasticizers, as well as the influence of the gut microbiome and numerous lifestyle circumstances. The effects of such a wide range of factors on allergic responses to an array of potential allergens is complex and the severity of these responses in a clinical setting are subsequently not easy to predict at the present time. However, some parameters which condition a pro-allergic immune response, including severe anaphylaxis, are becoming clearer. This review summarises what we currently know, and don’t know, about the factors which influence developing pro-allergic immunity particularly during the early-life perinatal period.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"27 1","pages":""},"PeriodicalIF":9.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141770172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Regulation in the Induction of Trained Immunity. 训练免疫诱导过程中的代谢调节

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-25 DOI: 10.1007/s00281-024-01015-8

Anaisa V Ferreira, Jorge Domínguez-Andrés, Laura M Merlo Pich, Leo A B Joosten, Mihai G Netea

{"title":"Metabolic Regulation in the Induction of Trained Immunity.","authors":"Anaisa V Ferreira, Jorge Domínguez-Andrés, Laura M Merlo Pich, Leo A B Joosten, Mihai G Netea","doi":"10.1007/s00281-024-01015-8","DOIUrl":"10.1007/s00281-024-01015-8","url":null,"abstract":"The innate immune system exhibits features of memory, termed trained immunity, which promote faster and more robust responsiveness to heterologous challenges. Innate immune memory is sustained through epigenetic modifications, affecting gene accessibility, and promoting a tailored gene transcription for an enhanced immune response. Alterations in the epigenetic landscape are intertwined with metabolic rewiring. Here, we review the metabolic pathways that underscore the induction and maintenance of trained immunity, including glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, and amino acid and lipid metabolism. The intricate interplay of these pathways is pivotal for establishing innate immune memory in distinct cellular compartments. We explore in particular the case of resident lung alveolar macrophages. We propose that leveraging the memory of the innate immune system may present therapeutic potential. Specifically, targeting the metabolic programs of innate immune cells is an emerging strategy for clinical interventions, either to boost immune responses in immunosuppressed conditions or to mitigate maladaptive activation in hyperinflammatory diseases.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 3-4","pages":"7"},"PeriodicalIF":7.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the tumor microenvironment to boost adoptive T cell therapy with engineered lymphocytes for solid tumors. 利用肿瘤微环境，用工程淋巴细胞促进实体瘤的采纳 T 细胞疗法。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-25 DOI: 10.1007/s00281-024-01011-y

Martina Spiga, Elisa Martini, Maria Chiara Maffia, Fabio Ciceri, Eliana Ruggiero, Alessia Potenza, Chiara Bonini

{"title":"Harnessing the tumor microenvironment to boost adoptive T cell therapy with engineered lymphocytes for solid tumors.","authors":"Martina Spiga, Elisa Martini, Maria Chiara Maffia, Fabio Ciceri, Eliana Ruggiero, Alessia Potenza, Chiara Bonini","doi":"10.1007/s00281-024-01011-y","DOIUrl":"10.1007/s00281-024-01011-y","url":null,"abstract":"Adoptive cell therapy (ACT) using Chimeric Antigen Receptor (CAR) and T Cell Receptor (TCR) engineered T cells represents an innovative therapeutic approach for the treatment of hematological malignancies, yet its application for solid tumors is still suboptimal. The tumor microenvironment (TME) places several challenges to overcome for a satisfactory therapeutic effect, such as physical barriers (fibrotic capsule and stroma), and inhibitory signals impeding T cell function. Some of these obstacles can be faced by combining ACT with other anti-tumor approaches, such as chemo/radiotherapy and checkpoint inhibitors. On the other hand, cutting edge technological tools offer the opportunity to overcome and, in some cases, take advantage of TME intrinsic characteristics to boost ACT efficacy. These include: the exploitation of chemokine gradients and integrin expression for preferential T-cell homing and extravasation; metabolic changes that have direct or indirect effects on TCR-T and CAR-T cells by increasing antigen presentation and reshaping T cell phenotype; introduction of additional synthetic receptors on TCR-T and CAR-T cells with the aim of increasing T cells survival and fitness.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 3-4","pages":"8"},"PeriodicalIF":7.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of galectins in the regulation of autophagy and inflammasome in host immunity. galectins 在宿主免疫中调控自噬和炎性体的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-23 DOI: 10.1007/s00281-024-01018-5

Tzu-Han Lo, I-Chun Weng, Hung-Lin Chen, Fu-Tong Liu

引用次数: 0

Riding the storm: managing cytokine-related toxicities in CAR-T cell therapy. 乘风破浪：CAR-T 细胞疗法中细胞因子相关毒性的管理。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-16 DOI: 10.1007/s00281-024-01013-w

Andrew D Hughes, David T Teachey, Caroline Diorio

{"title":"Riding the storm: managing cytokine-related toxicities in CAR-T cell therapy.","authors":"Andrew D Hughes, David T Teachey, Caroline Diorio","doi":"10.1007/s00281-024-01013-w","DOIUrl":"10.1007/s00281-024-01013-w","url":null,"abstract":"The advent of chimeric antigen receptor T cells (CAR-T) has been a paradigm shift in cancer immunotherapeutics, with remarkable outcomes reported for a growing catalog of malignancies. While CAR-T are highly effective in multiple diseases, salvaging patients who were considered incurable, they have unique toxicities which can be life-threatening. Understanding the biology and risk factors for these toxicities has led to targeted treatment approaches which can mitigate them successfully. The three toxicities of particular interest are cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and immune effector cell-associated hemophagocytic lymphohistiocytosis (HLH)-like syndrome (IEC-HS). Each of these is characterized by cytokine storm and hyperinflammation; however, they differ mechanistically with regard to the cytokines and immune cells that drive the pathophysiology. We summarize the current state of the field of CAR-T-associated toxicities, focusing on underlying biology and how this informs toxicity management and prevention. We also highlight several emerging agents showing promise in preclinical models and the clinic. Many of these established and emerging agents do not appear to impact the anti-tumor function of CAR-T, opening the door to additional and wider CAR-T applications.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 3-4","pages":"5"},"PeriodicalIF":7.9,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11252192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of microglia in early neurodevelopment and the effects of maternal immune activation. 小胶质细胞在早期神经发育中的作用以及母体免疫激活的影响。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-11 DOI: 10.1007/s00281-024-01017-6

L J M Mastenbroek, S M Kooistra, B J L Eggen, J R Prins

{"title":"The role of microglia in early neurodevelopment and the effects of maternal immune activation.","authors":"L J M Mastenbroek, S M Kooistra, B J L Eggen, J R Prins","doi":"10.1007/s00281-024-01017-6","DOIUrl":"10.1007/s00281-024-01017-6","url":null,"abstract":"Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia and autism spectrum disorder. Microglia, the tissue-resident macrophages of the central nervous system, are implicated as potential mediators of this increased risk. Early in development, microglia start populating the embryonic central nervous system and in addition to their traditional role as immune responders under homeostatic conditions, microglia are also intricately involved in various early neurodevelopmental processes. The timing of immune activation may interfere with microglia functioning during early neurodevelopment, potentially leading to long-term consequences in postnatal life. In this review we will discuss the involvement of microglia in brain development during the prenatal and early postnatal stages of life, while also examining the effects of maternal immune activation on microglia and neurodevelopmental processes. Additionally, we discuss recent single cell RNA-sequencing studies focusing on microglia during prenatal development, and hypothesize how early life microglial priming, potentially through epigenetic reprogramming, may be related to neurodevelopmental disorders.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 1-2","pages":"1"},"PeriodicalIF":7.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0