Seminars in Immunopathology最新文献_第5页

Vascular galectins in tumor angiogenesis and cancer immunity. 肿瘤血管生成和癌症免疫中的血管半凝集素

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-11 DOI: 10.1007/s00281-024-01014-9

Victor L J L Thijssen

{"title":"Vascular galectins in tumor angiogenesis and cancer immunity.","authors":"Victor L J L Thijssen","doi":"10.1007/s00281-024-01014-9","DOIUrl":"10.1007/s00281-024-01014-9","url":null,"abstract":"Sustained tumor angiogenesis, i.e., the induction and maintenance of blood vessel growth by tumor cells, is one of the hallmarks of cancer. The vascularization of malignant tissues not only facilitates tumor growth and metastasis, but also contributes to immune evasion. Important players in all these processes are the endothelial cells which line the luminal side of blood vessel. In the tumor vasculature, these cells are actively involved in angiogenesis as well in the hampered recruitment of immune cells. This is the result of the abnormal tumor microenvironment which triggers both angiostimulatory and immune inhibitory gene expression profiles in endothelial cells. In recent years, it has become evident that galectins constitute a protein family that is expressed in the tumor endothelium. Moreover, several members of this glycan-binding protein family have been found to facilitate tumor angiogenesis and stimulate immune suppression. All this has identified galectins as potential therapeutic targets to simultaneously hamper tumor angiogenesis and alleviate immune suppression. The current review provides a brief introduction in the human galectin protein family. The current knowledge regarding the expression and regulation of galectins in endothelial cells is summarized. Furthermore, an overview of the role that endothelial galectins play in tumor angiogenesis and tumor immunomodulation is provided. Finally, some outstanding questions are discussed that should be addressed by future research efforts. This will help to fully understand the contribution of endothelial galectins to tumor progression and to exploit endothelial galectins for cancer therapy.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 1-2","pages":"3"},"PeriodicalIF":7.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota-derived metabolites tune host homeostasis fate. 肠道微生物群衍生代谢物调节宿主的平衡命运

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-11 DOI: 10.1007/s00281-024-01012-x

Seungil Kim, Sang-Uk Seo, Mi-Na Kweon

引用次数: 0

Intracellular galectin interactions in health and disease. 健康和疾病中细胞内 galectin 的相互作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-11 DOI: 10.1007/s00281-024-01010-z

Ralf Jacob, Lena-Sophie Gorek

{"title":"Intracellular galectin interactions in health and disease.","authors":"Ralf Jacob, Lena-Sophie Gorek","doi":"10.1007/s00281-024-01010-z","DOIUrl":"10.1007/s00281-024-01010-z","url":null,"abstract":"In the galectin family, a group of lectins is united by their evolutionarily conserved carbohydrate recognition domains. These polypeptides play a role in various cellular processes and are implicated in disease mechanisms such as cancer, fibrosis, infection, and inflammation. Following synthesis in the cytosol, manifold interactions of galectins have been described both extracellularly and intracellularly. Extracellular galectins frequently engage with glycoproteins or glycolipids in a carbohydrate-dependent manner. Intracellularly, galectins bind to non-glycosylated proteins situated in distinct cellular compartments, each with multiple cellular functions. This diversity complicates attempts to form a comprehensive understanding of the role of galectin molecules within the cell. This review enumerates intracellular galectin interaction partners and outlines their involvement in cellular processes. The intricate connections between galectin functions and pathomechanisms are illustrated through discussions of intracellular galectin assemblies in immune and cancer cells. This underscores the imperative need to fully comprehend the interplay of galectins with the cellular machinery and to devise therapeutic strategies aimed at counteracting the establishment of galectin-based disease mechanisms.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 1-2","pages":"4"},"PeriodicalIF":7.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11239732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Epithelial recognition and elimination against aberrant cells 出版商更正：上皮细胞识别和消除异常细胞

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-04-24 DOI: 10.1007/s00281-024-01009-6

Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama

引用次数: 0

Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells 第 3 组先天性淋巴细胞调控的疾病发病机制和屏障功能

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-02-02 DOI: 10.1007/s00281-024-01000-1

Ayana Mori, Hiroshi Ohno, Naoko Satoh-Takayama

{"title":"Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells","authors":"Ayana Mori, Hiroshi Ohno, Naoko Satoh-Takayama","doi":"10.1007/s00281-024-01000-1","DOIUrl":"https://doi.org/10.1007/s00281-024-01000-1","url":null,"abstract":"The mucosal surface is in constant contact with foreign antigens and is regulated by unique mechanisms that are different from immune responses in the peripheral organs. For the last several decades, only adaptive immune cells such as helper T (Th) cells, Th1, Th2, or Th17 were targeted to study a wide variety of immune responses in the mucosal tissues. However, since their discovery, innate lymphoid cells (ILCs) have been attracting attention as a unique subset of immune cells that provide border defense with various functions and tissue specificity. ILCs are classified into different groups based on cell differentiation and functions. Group 3 innate lymphoid cells (ILC3s) are particularly in close proximity to mucosal surfaces and therefore have the opportunity to be exposed to a variety of bacteria including pathogenic bacteria. In recent years, studies have also provided much evidence that ILC3s contribute to disease pathogenesis as well as the defense of mucosal surfaces by rapidly responding to pathogens and coordinating other immune cells. As the counterpart of helper T cells, ILC3s together with other ILC subsets establish the immune balance between adaptive and innate immunity in protecting us from invasion or encounter with non-self-antigens for maintaining a complex homeostasis. In this review, we summarize recent advances in our understanding of ILCs, with a particular focus on the function of ILC3s in their involvement in bacterial infection and disease pathogenesis.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"14 1","pages":""},"PeriodicalIF":9.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity 糖蛋白 2 是炎症与免疫之间粘膜平衡的肠道守门员

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-03 DOI: 10.1007/s00281-023-00999-z

引用次数: 0

Causes and costs of global COVID-19 vaccine inequity. 全球新冠肺炎疫苗不公平的原因和代价。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-10-23 DOI: 10.1007/s00281-023-00998-0

Maddalena Ferranna

引用次数: 0

Physiological and immunological barriers in the lung. 肺部的生理和免疫屏障。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2024-03-07 DOI: 10.1007/s00281-024-01003-y

Takahiro Kageyama, Takashi Ito, Shigeru Tanaka, Hiroshi Nakajima

引用次数: 0

Epithelial recognition and elimination against aberrant cells. 上皮细胞识别和消除异常细胞。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2024-02-27 DOI: 10.1007/s00281-024-01001-0

Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama

{"title":"Epithelial recognition and elimination against aberrant cells.","authors":"Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama","doi":"10.1007/s00281-024-01001-0","DOIUrl":"10.1007/s00281-024-01001-0","url":null,"abstract":"Epithelial cells, which are non-immune cells, not only function as a physical defence barrier but also continuously monitor and eliminate aberrant epithelial cells in their vicinity. In other words, it has become evident that epithelial cells possess immune cell-like functions. In fact, recent research has revealed that epithelial cells recognise the Major Histocompatibility Complex I (MHC-I) of aberrant cells as a mechanism for surveillance. This cellular defence mechanism of epithelial cells probably detects aberrant cells more promptly than the conventional immune response, making it a novel and primary biological defence. Furthermore, there is the potential for this new immune-like biological defence mechanism to establish innovative treatment for disease prevention, leading to increasing anticipation for its future medical applications. In this review, we aim to summarise the recognition and attack mechanisms of aberrant cells by epithelial cells in mammals, with a particular focus on the field of cancer. Additionally, we discuss the potential therapeutic applications of epithelial cell-based defence against cancer, including novel prophylactic treatment methods based on molecular mechanisms.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":" ","pages":"521-532"},"PeriodicalIF":9.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The overlooked bacterial pandemic. 被忽视的细菌大流行

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-12-11 DOI: 10.1007/s00281-023-00997-1

Danilo Gomes Moriel, Diego Piccioli, Maria Michelina Raso, Mariagrazia Pizza

引用次数: 0