Seminars in Immunopathology最新文献

IgE and non-IgE-mediated pathways in anaphylaxis. 过敏反应中IgE和非IgE介导的途径。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-13 DOI: 10.1007/s00281-025-01056-7

Margitta Worm, Kristijan Pazur, Payam Morakabati, Davender Redhu

引用次数: 0

Micro-chimerism: from evolution to revolution. 微嵌合：从进化到革命。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-06 DOI: 10.1007/s00281-025-01060-x

Christopher Urbschat, Petra C Arck

引用次数: 0

Dermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment. 皮肌炎：关注皮肤特征，发病机制及其对治疗的影响。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-06 DOI: 10.1007/s00281-025-01054-9

Hammad Ali, Aretha On, Enze Xing, Catherine Shen, Victoria P Werth

{"title":"Dermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment.","authors":"Hammad Ali, Aretha On, Enze Xing, Catherine Shen, Victoria P Werth","doi":"10.1007/s00281-025-01054-9","DOIUrl":"10.1007/s00281-025-01054-9","url":null,"abstract":"Dermatomyositis (DM) is an infrequently encountered idiopathic inflammatory myopathy distinguished by distinctive cutaneous manifestations and/or progressive muscle weakness. This review provides an updated exploration of DM, emphasizing cutaneous features, etiopathogenesis, and therapeutic implications. DM presents a heterogeneous spectrum, ranging from classic forms involving both skin and muscle to clinically amyopathic DM, which lacks significant muscle involvement but carries risks like interstitial lung disease (ILD) and malignancy. Recent advances in understanding DM pathogenesis underscore the roles of myositis-specific autoantibodies, type I interferons, and cytokine dysregulation in disease activity and clinical outcomes. Specific antibodies such as anti-Mi-2, anti-TIF1γ, and anti-MDA5 define subtypes of DM, aiding diagnosis, prognosis, and tailored management strategies. While conventional immunosuppressive therapies like glucocorticoids and antimalarials form the cornerstone of treatment, many cases remain refractory, particularly involving chronic skin disease. Emerging targeted therapies, including Janus kinase inhibitors and monoclonal antibodies, show promise in addressing type I interferon-driven pathways and refractory symptoms. Future research aims to refine diagnostic criteria, integrate biomarkers, utilize more robust outcome measures, and develop targeted therapeutics to improve outcomes while minimizing treatment-related toxicity. This review consolidates current knowledge and highlights the need for a multidisciplinary, individualized approach to managing DM, focusing on both established and novel treatment avenues.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"32"},"PeriodicalIF":9.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage clock of pregnancy: circadian and metabolic control of decidual macrophage. 妊娠巨噬细胞时钟：巨噬细胞个体的昼夜节律和代谢控制。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-18 DOI: 10.1007/s00281-025-01057-6

Dongyong Yang, Kristin Thiele, Tailang Yin, Lianghui Diao

{"title":"Macrophage clock of pregnancy: circadian and metabolic control of decidual macrophage.","authors":"Dongyong Yang, Kristin Thiele, Tailang Yin, Lianghui Diao","doi":"10.1007/s00281-025-01057-6","DOIUrl":"https://doi.org/10.1007/s00281-025-01057-6","url":null,"abstract":"The temporal regulation of immune responses during pregnancy is crucial for successful gestation. Yet, the specific mechanisms controlling macrophage function across gestational stages remain poorly understood. Here, we introduce the concept of the \"macrophage clock of pregnancy\", describing how molecular clock and cellular metabolism coordinate macrophage function across gestational stages. The molecular mechanisms underlying circadian control of macrophage function are examined, as well as hormones secreted by the pineal gland and their relevance to pregnancy-related processes. These pathways orchestrate key macrophage functions in pregnancy: modifying the uterine epithelium during implantation, supporting spiral artery remodeling, maintaining fetal tolerance, and initiating labor. Recent evidence shows that environmental factors such as shift work and extension of artificial light exposure can disturb macrophage function. The temporal regulation of macrophages also depends on metabolic signals, with distinct patterns of glycolysis, oxidative phosphorylation, and fatty acid metabolism corresponding to different gestational phases. Disruption of these temporal and metabolic signals - whether through circadian misalignment or metabolic dysfunction - correlates with pregnancy complications including recurrent pregnancy loss, preeclampsia, and preterm birth. We propose that monitoring macrophage temporal dynamics could provide early indicators of pregnancy complications, while targeting clock-controlled pathways may offer new therapeutic strategies. Understanding the temporal aspects of macrophage function opens new approaches for treating pregnancy disorders through precise immunological timing.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"30"},"PeriodicalIF":7.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunopathological insights into endometriosis: from research advances to future treatments. 子宫内膜异位症的免疫病理学见解：从研究进展到未来治疗。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-18 DOI: 10.1007/s00281-025-01058-5

Yangyang Dai, Zi Ye, Xiang Lin, Songying Zhang

{"title":"Immunopathological insights into endometriosis: from research advances to future treatments.","authors":"Yangyang Dai, Zi Ye, Xiang Lin, Songying Zhang","doi":"10.1007/s00281-025-01058-5","DOIUrl":"10.1007/s00281-025-01058-5","url":null,"abstract":"Endometriosis is a chronic gynecological disease and a major global concern for women's health. With advancing knowledge of the condition, the classic definition of endometriosis as \"endometrium-like tissue outside the uterus\" now appears insufficient to explain its pathophysiology, as it overlooks the complex involvement of multiple systems in disease development. Immunological changes have been recognized in endometriosis for decades, and growing evidence substantiates that immunopathological alterations are a hallmark of the disease. Imbalanced immune cell populations and cellular dysfunctions within both the innate and adaptive immune systems, along with aberrant inflammatory cytokines, contribute to the inflammation associated with endometriosis. Moreover, immune cell dysfunctions such as reduced natural killer (NK) cell activity, impaired dendritic cell (DC) maturation and inhibited T cell function via immune checkpoints (ICPs) make the microenvironment also immune-suppressive, facilitating the immune evasion of endometriotic lesions. Endometriosis associated inflammation also sabotages female fertility across multiple stages, including ovarian function, fertilization, embryo development and pregnancy complications. Recognition of the inflammatory and immune-suppressive microenvironment associated with endometriosis leads to the discovery of potential immunotherapeutic targets. Established treatments like non-steroid anti-inflammatory drugs (NSAIDs) and hormone therapies harbor immunomodulatory properties. Other immune-based therapies such as immune cell therapies, cytokine-targeting therapies and immune checkpoint inhibitors (ICIs), which have demonstrated significant efficacy in many chronic inflammatory diseases including cancers, may hold substantial promise as future treatments for endometriosis.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"31"},"PeriodicalIF":7.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of endocrine disrupting chemicals on macrophages at the maternal-fetal interface. 内分泌干扰物对母胎界面巨噬细胞的影响。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-16 DOI: 10.1007/s00281-025-01055-8

Bin Zhao, Qinsheng Lu, Miaojuan Chen, Gendie E Lash

引用次数: 0

Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease. 单独肠内营养治疗克罗恩病的机制。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-02 DOI: 10.1007/s00281-025-01053-w

Krammel Tina, Nie Jiatong, Häcker Deborah, Schwerd Tobias, Aguanno Doriane, Haller Dirk

{"title":"Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease.","authors":"Krammel Tina, Nie Jiatong, Häcker Deborah, Schwerd Tobias, Aguanno Doriane, Haller Dirk","doi":"10.1007/s00281-025-01053-w","DOIUrl":"10.1007/s00281-025-01053-w","url":null,"abstract":"Crohn's disease (CD) is a chronic, relapsing multifactorial inflammatory condition of the gastrointestinal tract, which is diagnosed under the age of 17 in 25% of patients, categorized as pediatric CD (pCD). Exclusive enteral nutrition (EEN) is a first-line therapy for inducing remission in pCD, yet its precise mechanisms remain poorly understood. This review summarizes the complex interplay of EEN-induced protective changes in the gut microbiota, epithelial barrier function and mucosal immune responses. EEN reshapes the gut microbiome by excluding potential pathobionts from the gut mucus layer and increasing protective bacterial and dietary metabolites. Emerging evidence highlights the role of EEN in modulating mitochondrial function, tryptophan metabolism and other metabolites in the intestinal epithelium and immune cells, which may contribute to its therapeutic efficacy. However, high variability in microbiome responses across clinical cohorts and discrepancies between clinical trials and animal models warrant further research to identify functional consequences and therapeutic mechanisms of EEN.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"28"},"PeriodicalIF":7.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chimerism and immunological tolerance in solid organ transplantation. 实体器官移植中的嵌合与免疫耐受。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-05-19 DOI: 10.1007/s00281-025-01052-x

Birte Ohm, Anastasios D Giannou, David Harriman, Jun Oh, Wolfgang Jungraithmayr, Dimitra E Zazara

{"title":"Chimerism and immunological tolerance in solid organ transplantation.","authors":"Birte Ohm, Anastasios D Giannou, David Harriman, Jun Oh, Wolfgang Jungraithmayr, Dimitra E Zazara","doi":"10.1007/s00281-025-01052-x","DOIUrl":"10.1007/s00281-025-01052-x","url":null,"abstract":"In solid organ transplantation, chimerism inevitably occurs via the coexistence of donor-derived cells from the graft and host cells throughout the recipient. However, long-term immunosuppressive treatment is needed to suppress host immune responses to the foreign organ graft. The deliberate induction of stable mixed bone marrow chimerism to achieve donor-specific immunological tolerance in solid organ graft recipients is an ambitious goal that may significantly contribute to the long-term survival of solid organ grafts and their recipients. While this strategy has been effectively established in laboratory animals and some promising clinical case series have been reported, widespread clinical application is still limited by the toxicity of the necessary conditioning regimens. On the other hand, the naturally occurring chimeric state resulting from the bidirectional transplacental cell trafficking during pregnancy, the so-called feto-maternal microchimerism, can also induce immune tolerance and thus influence the outcome of mother-to-child or child-to-mother organ transplantation. This review provides an overview of the field's historical development, clinical results, and underlying principles of (micro) chimerism-based tolerance.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"27"},"PeriodicalIF":7.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune checkpoint for pregnancy. 怀孕免疫检查点。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-05-02 DOI: 10.1007/s00281-025-01051-y

Xiaohui Hu, Siying Lai, Aihua Liao

引用次数: 0

The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells. 半乳糖凝集素-1在免疫中的利弊：它在免疫细胞功能、细胞凋亡和癌症免疫治疗中的作用，重点是T细胞。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-04-03 DOI: 10.1007/s00281-025-01047-8

Julianna Novák, Tamás Takács, Álmos Tilajka, Loretta László, Orsolya Oravecz, Emese Farkas, Nándor Gábor Than, László Buday, Andrea Balogh, Virág Vas

{"title":"The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells.","authors":"Julianna Novák, Tamás Takács, Álmos Tilajka, Loretta László, Orsolya Oravecz, Emese Farkas, Nándor Gábor Than, László Buday, Andrea Balogh, Virág Vas","doi":"10.1007/s00281-025-01047-8","DOIUrl":"10.1007/s00281-025-01047-8","url":null,"abstract":"Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is a double-edged sword in immunity. On one hand, it plays a crucial role in regulating diverse immune cell functions, including the apoptosis of activated T cells. These processes are key in resolving inflammation and preventing autoimmune diseases. On the other hand, Gal-1 has significant implications in cancer, where tumor cells and the tumor microenvironment (TME) (e.g., tumor-associated fibroblasts, myeloid-derived suppressor cells) secrete Gal-1 to evade immune surveillance and promote cancer cell growth. Within the TME, Gal-1 enhances the differentiation of tolerogenic dendritic cells, induces the apoptosis of effector T cells, and enhances the proliferation of regulatory T cells, collectively facilitating tumor immune escape. Therefore, targeting Gal-1 holds the potential to boost anti-tumor immunity and improve the efficacy of cancer immunotherapy. This review provides insights into the intricate role of Gal-1 in immune cell regulation, with an emphasis on T cells, and elucidates how tumors exploit Gal-1 for immune evasion and growth. Furthermore, we discuss the potential of Gal-1 as a therapeutic target to augment current immunotherapies across various cancer types.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"24"},"PeriodicalIF":7.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0