Seminars in Immunopathology最新文献

Crosstalk between the microbiota and intestinal dendritic cells in IBD. IBD中微生物群与肠道树突状细胞之间的串扰。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-09-30 DOI: 10.1007/s00281-025-01062-9

Philine Letz, Samuel Huber, Lis N Velasquez

{"title":"Crosstalk between the microbiota and intestinal dendritic cells in IBD.","authors":"Philine Letz, Samuel Huber, Lis N Velasquez","doi":"10.1007/s00281-025-01062-9","DOIUrl":"10.1007/s00281-025-01062-9","url":null,"abstract":"Conventional dendritic cells (cDCs) play a pivotal role in orchestrating the delicate balance between immunity and tolerance within the gastrointestinal tract by interacting with other cell types, particularly T cells. Meanwhile, the microbiota is critical for the induction and modulation of the immune system in the gut and plays a key role in the function of cDCs. So far, the study of intestinal cDCs has been encumbered by their limited numbers and phenotypic overlap with other myeloid cells. Recent advancements in single-cell sequencing technology have helped define cDCs and their subsets, while also providing valuable insights into the contribution of cDCs to Inflammatory Bowel Disease (IBD). However, the exact role of cDCs in IBD remains unclear, particularly in terms of how the microbiota influences their function in this context. In this review, we summarize the functions of cDCs in the intestine and during IBD, and the role of the microbiota in cDC biology. We also describe the current limitations in the study of cDCs and the microbiota, as well as new methods for studying DC-T cell communications in vivo, which can help increase our understanding of the function of cDCs in the intestine and develop new therapeutic strategies against IBD.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"37"},"PeriodicalIF":9.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerating the uterus: translational advances in endometrial bioengineering and immunotherapeutics. 子宫再生：子宫内膜生物工程和免疫治疗的翻译进展。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-09-30 DOI: 10.1007/s00281-025-01063-8

Danbi Lee, Youn-Jung Kang, Haengseok Song

{"title":"Regenerating the uterus: translational advances in endometrial bioengineering and immunotherapeutics.","authors":"Danbi Lee, Youn-Jung Kang, Haengseok Song","doi":"10.1007/s00281-025-01063-8","DOIUrl":"https://doi.org/10.1007/s00281-025-01063-8","url":null,"abstract":"Uterine disorders, such as thin endometrium and intrauterine adhesions, remain significant challenges in reproductive medicine, often leading to infertility and poor pregnancy outcomes. Recent advances in regenerative medicine and tissue engineering have led to the development of innovative therapeutic strategies aimed at restoring endometrial structure and function. Biomaterials play a central role in these advancements, serving not only as structural scaffolds and delivery vehicles for stem/progenitor cells and bioactive molecules but also as modulators of the tissue microenvironment by promoting angiogenesis and regulating immune responses. Mesenchymal stem cells from various sources, including female reproductive tissues, along with their extracellular vesicles, have demonstrated potential in promoting angiogenesis, reducing fibrosis, and modulating immune responses for endometrial repair. Additionally, platelet-rich plasma and a range of pharmacological agents-often with advanced drug delivery systems, such as nanocarriers-further contribute to endometrial regeneration. Engineered scaffolds, particularly those derived from decellularized extracellular matrix or fabricated using three-dimensional bioprinting technologies, closely mimic the biomechanical and biochemical properties of native endometrium. These scaffolds facilitate cellular engraftment and provide valuable platforms for in vitro modeling of endometrial physiology. The development of uterus-derived extracellular matrix scaffolds with immunologically compatible biomaterials and organoids marks a pivotal step toward reducing immune rejection and improving clinical applicability. This review highlights recent progress in biomaterial-based therapeutics for uterine regeneration and discusses the remaining challenges in shifting therapeutic paradigms of personalized and tissue-specific regenerative strategies.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"36"},"PeriodicalIF":9.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal and placental galectins: key players in the feto-maternal symbiotic tango. 母体和胎盘凝集素：胎儿-母体共生探戈中的关键角色。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-21 DOI: 10.1007/s00281-025-01061-w

Orsolya Oravecz, Yiran Xie, Andrea Balogh, Máté Posta, Charlotte Harms, Emese Farkas, Sophia Borowski, Júlia Szekeres-Barthó, Nándor Gábor Than, Sandra M Blois

{"title":"Maternal and placental galectins: key players in the feto-maternal symbiotic tango.","authors":"Orsolya Oravecz, Yiran Xie, Andrea Balogh, Máté Posta, Charlotte Harms, Emese Farkas, Sophia Borowski, Júlia Szekeres-Barthó, Nándor Gábor Than, Sandra M Blois","doi":"10.1007/s00281-025-01061-w","DOIUrl":"https://doi.org/10.1007/s00281-025-01061-w","url":null,"abstract":"Galectins, a family of β-galactoside-binding proteins, are critical in regulating feto-maternal interactions during pregnancy. Their evolutionary trajectory is reflected in their expression patterns and diverse functions in embryo implantation, trophoblast invasion, and maternal immune and vascular adaptation, contributing to healthy placentation and uncomplicated pregnancy. Galectin-1 (gal-1), one of the most ancient galectins, plays a pivotal role in feto-maternal immune regulation, acting predominantly from the maternal side to promote immune tolerance, a function integrated early in placental mammalian evolution. In contrast, anthropoid primates introduced a unique set of fetal (placental) galectins (gal-13, gal-14, and gal-16) through birth-and-death evolution, with these genes localized on human chromosome 19. Notably, these primate species have evolved varying degrees of deep placentation, with humans exhibiting the deepest, which facilitates enhanced nutrient delivery to the fetus, particularly for brain development. Placental galectins have been implicated in the evolution of immune tolerance mechanisms that support deep placentation. During pregnancy, reduced expression of maternal galectins (e.g., gal-1) and placental galectins (e.g., gal-13) has been associated with severe obstetric complications, signaling disruptions in feto-maternal tolerance. This review provides a comprehensive overview of gal-1, gal-13, gal-14, and gal-16, highlighting their shared and unique roles in maternal and placental immune regulation and placental development. Additionally, the review explores the potential of maternal versus placental galectins as biomarkers and therapeutic targets to improve diagnostic and treatment strategies for adverse pregnancy outcomes.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"35"},"PeriodicalIF":9.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgE and non-IgE-mediated pathways in anaphylaxis. 过敏反应中IgE和非IgE介导的途径。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-13 DOI: 10.1007/s00281-025-01056-7

Margitta Worm, Kristijan Pazur, Payam Morakabati, Davender Redhu

引用次数: 0

Micro-chimerism: from evolution to revolution. 微嵌合：从进化到革命。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-06 DOI: 10.1007/s00281-025-01060-x

Christopher Urbschat, Petra C Arck

引用次数: 0

Dermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment. 皮肌炎：关注皮肤特征，发病机制及其对治疗的影响。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-08-06 DOI: 10.1007/s00281-025-01054-9

Hammad Ali, Aretha On, Enze Xing, Catherine Shen, Victoria P Werth

{"title":"Dermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment.","authors":"Hammad Ali, Aretha On, Enze Xing, Catherine Shen, Victoria P Werth","doi":"10.1007/s00281-025-01054-9","DOIUrl":"10.1007/s00281-025-01054-9","url":null,"abstract":"Dermatomyositis (DM) is an infrequently encountered idiopathic inflammatory myopathy distinguished by distinctive cutaneous manifestations and/or progressive muscle weakness. This review provides an updated exploration of DM, emphasizing cutaneous features, etiopathogenesis, and therapeutic implications. DM presents a heterogeneous spectrum, ranging from classic forms involving both skin and muscle to clinically amyopathic DM, which lacks significant muscle involvement but carries risks like interstitial lung disease (ILD) and malignancy. Recent advances in understanding DM pathogenesis underscore the roles of myositis-specific autoantibodies, type I interferons, and cytokine dysregulation in disease activity and clinical outcomes. Specific antibodies such as anti-Mi-2, anti-TIF1γ, and anti-MDA5 define subtypes of DM, aiding diagnosis, prognosis, and tailored management strategies. While conventional immunosuppressive therapies like glucocorticoids and antimalarials form the cornerstone of treatment, many cases remain refractory, particularly involving chronic skin disease. Emerging targeted therapies, including Janus kinase inhibitors and monoclonal antibodies, show promise in addressing type I interferon-driven pathways and refractory symptoms. Future research aims to refine diagnostic criteria, integrate biomarkers, utilize more robust outcome measures, and develop targeted therapeutics to improve outcomes while minimizing treatment-related toxicity. This review consolidates current knowledge and highlights the need for a multidisciplinary, individualized approach to managing DM, focusing on both established and novel treatment avenues.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"32"},"PeriodicalIF":9.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage clock of pregnancy: circadian and metabolic control of decidual macrophage. 妊娠巨噬细胞时钟：巨噬细胞个体的昼夜节律和代谢控制。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-18 DOI: 10.1007/s00281-025-01057-6

Dongyong Yang, Kristin Thiele, Tailang Yin, Lianghui Diao

{"title":"Macrophage clock of pregnancy: circadian and metabolic control of decidual macrophage.","authors":"Dongyong Yang, Kristin Thiele, Tailang Yin, Lianghui Diao","doi":"10.1007/s00281-025-01057-6","DOIUrl":"https://doi.org/10.1007/s00281-025-01057-6","url":null,"abstract":"The temporal regulation of immune responses during pregnancy is crucial for successful gestation. Yet, the specific mechanisms controlling macrophage function across gestational stages remain poorly understood. Here, we introduce the concept of the \"macrophage clock of pregnancy\", describing how molecular clock and cellular metabolism coordinate macrophage function across gestational stages. The molecular mechanisms underlying circadian control of macrophage function are examined, as well as hormones secreted by the pineal gland and their relevance to pregnancy-related processes. These pathways orchestrate key macrophage functions in pregnancy: modifying the uterine epithelium during implantation, supporting spiral artery remodeling, maintaining fetal tolerance, and initiating labor. Recent evidence shows that environmental factors such as shift work and extension of artificial light exposure can disturb macrophage function. The temporal regulation of macrophages also depends on metabolic signals, with distinct patterns of glycolysis, oxidative phosphorylation, and fatty acid metabolism corresponding to different gestational phases. Disruption of these temporal and metabolic signals - whether through circadian misalignment or metabolic dysfunction - correlates with pregnancy complications including recurrent pregnancy loss, preeclampsia, and preterm birth. We propose that monitoring macrophage temporal dynamics could provide early indicators of pregnancy complications, while targeting clock-controlled pathways may offer new therapeutic strategies. Understanding the temporal aspects of macrophage function opens new approaches for treating pregnancy disorders through precise immunological timing.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"30"},"PeriodicalIF":7.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunopathological insights into endometriosis: from research advances to future treatments. 子宫内膜异位症的免疫病理学见解：从研究进展到未来治疗。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-18 DOI: 10.1007/s00281-025-01058-5

Yangyang Dai, Zi Ye, Xiang Lin, Songying Zhang

{"title":"Immunopathological insights into endometriosis: from research advances to future treatments.","authors":"Yangyang Dai, Zi Ye, Xiang Lin, Songying Zhang","doi":"10.1007/s00281-025-01058-5","DOIUrl":"10.1007/s00281-025-01058-5","url":null,"abstract":"Endometriosis is a chronic gynecological disease and a major global concern for women's health. With advancing knowledge of the condition, the classic definition of endometriosis as \"endometrium-like tissue outside the uterus\" now appears insufficient to explain its pathophysiology, as it overlooks the complex involvement of multiple systems in disease development. Immunological changes have been recognized in endometriosis for decades, and growing evidence substantiates that immunopathological alterations are a hallmark of the disease. Imbalanced immune cell populations and cellular dysfunctions within both the innate and adaptive immune systems, along with aberrant inflammatory cytokines, contribute to the inflammation associated with endometriosis. Moreover, immune cell dysfunctions such as reduced natural killer (NK) cell activity, impaired dendritic cell (DC) maturation and inhibited T cell function via immune checkpoints (ICPs) make the microenvironment also immune-suppressive, facilitating the immune evasion of endometriotic lesions. Endometriosis associated inflammation also sabotages female fertility across multiple stages, including ovarian function, fertilization, embryo development and pregnancy complications. Recognition of the inflammatory and immune-suppressive microenvironment associated with endometriosis leads to the discovery of potential immunotherapeutic targets. Established treatments like non-steroid anti-inflammatory drugs (NSAIDs) and hormone therapies harbor immunomodulatory properties. Other immune-based therapies such as immune cell therapies, cytokine-targeting therapies and immune checkpoint inhibitors (ICIs), which have demonstrated significant efficacy in many chronic inflammatory diseases including cancers, may hold substantial promise as future treatments for endometriosis.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"31"},"PeriodicalIF":7.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of endocrine disrupting chemicals on macrophages at the maternal-fetal interface. 内分泌干扰物对母胎界面巨噬细胞的影响。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-16 DOI: 10.1007/s00281-025-01055-8

Bin Zhao, Qinsheng Lu, Miaojuan Chen, Gendie E Lash

引用次数: 0

Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease. 单独肠内营养治疗克罗恩病的机制。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-07-02 DOI: 10.1007/s00281-025-01053-w

Krammel Tina, Nie Jiatong, Häcker Deborah, Schwerd Tobias, Aguanno Doriane, Haller Dirk

{"title":"Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease.","authors":"Krammel Tina, Nie Jiatong, Häcker Deborah, Schwerd Tobias, Aguanno Doriane, Haller Dirk","doi":"10.1007/s00281-025-01053-w","DOIUrl":"10.1007/s00281-025-01053-w","url":null,"abstract":"Crohn's disease (CD) is a chronic, relapsing multifactorial inflammatory condition of the gastrointestinal tract, which is diagnosed under the age of 17 in 25% of patients, categorized as pediatric CD (pCD). Exclusive enteral nutrition (EEN) is a first-line therapy for inducing remission in pCD, yet its precise mechanisms remain poorly understood. This review summarizes the complex interplay of EEN-induced protective changes in the gut microbiota, epithelial barrier function and mucosal immune responses. EEN reshapes the gut microbiome by excluding potential pathobionts from the gut mucus layer and increasing protective bacterial and dietary metabolites. Emerging evidence highlights the role of EEN in modulating mitochondrial function, tryptophan metabolism and other metabolites in the intestinal epithelium and immune cells, which may contribute to its therapeutic efficacy. However, high variability in microbiome responses across clinical cohorts and discrepancies between clinical trials and animal models warrant further research to identify functional consequences and therapeutic mechanisms of EEN.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"28"},"PeriodicalIF":7.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0