Seminars in Immunopathology最新文献_第10页

Tissue-resident immunity in the lung: a first-line defense at the environmental interface. 肺组织驻留免疫:环境界面的第一道防线。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-11-01 DOI: 10.1007/s00281-022-00964-2

Dimitra E Zazara, Ioannis Belios, Jöran Lücke, Tao Zhang, Anastasios D Giannou

引用次数: 5

Heterogeneity of tissue-resident immunity across organs and in health and disease. 组织驻留免疫跨器官、健康和疾病的异质性。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-11-01 DOI: 10.1007/s00281-022-00967-z

Petra Clara Arck, Federica Sallusto

引用次数: 1

Liver-resident memory T cells: life in lockdown. 肝脏驻留记忆T细胞:被封锁的生命

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-11-01 DOI: 10.1007/s00281-022-00932-w

Laura J Pallett, Mala K Maini

引用次数: 9

Tissue-resident memory T cells in the kidney. 肾脏中的组织常驻记忆T细胞。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-11-01 DOI: 10.1007/s00281-022-00927-7

Nariaki Asada, Pauline Ginsberg, Nicola Gagliani, Hans-Willi Mittrücker, Ulf Panzer

引用次数: 4

Basic principles of neuroimmunology. 神经免疫学的基本原理。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 Epub Date: 2022-06-22 DOI: 10.1007/s00281-022-00951-7

Tomomi M Yoshida, Andrew Wang, David A Hafler

{"title":"Basic principles of neuroimmunology.","authors":"Tomomi M Yoshida, Andrew Wang, David A Hafler","doi":"10.1007/s00281-022-00951-7","DOIUrl":"https://doi.org/10.1007/s00281-022-00951-7","url":null,"abstract":"The brain is an immune-privileged organ such that immune cell infiltration is highly regulated and better tolerating the introduction of antigen to reduce risk of harmful inflammation. Thus, the composition and the nature of the immune response is fundamentally different in the brain where avoiding immunopathology is prioritized compared to other peripheral organs. While the principle of immune privilege in the central nervous system (CNS) still holds true, the role of the immune system in the CNS has been revisited over the recent years. This redefining of immune privilege in the brain is a result of the recent re-discovery of the extensive CNS meningeal lymphatic system and the identification of resident T cells in the brain, meningeal layers, and its surrounding cerebrospinal fluid (CSF) in both humans and rodents. While neuro-immune interactions have been classically studied in the context of neuroinflammatory disease, recent works have also elucidated unconventional roles of immune-derived cytokines in neurological function, highlighting the many implications and potential of neuro-immune interactions. As a result, the study of neuro-immune interactions is becoming increasingly important in understanding both CNS homeostasis and disease. Here, we review the anatomically distinct immune compartments within the brain, the known mechanisms of leukocyte trafficking and infiltration into the CNS and unique transcriptional and functional characteristics of CNS-resident immune cells.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":" ","pages":"685-695"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40209459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The immunology of Parkinson's disease. 帕金森病的免疫学。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00947-3

Biqing Zhu, Dominic Yin, Hongyu Zhao, Le Zhang

{"title":"The immunology of Parkinson's disease.","authors":"Biqing Zhu, Dominic Yin, Hongyu Zhao, Le Zhang","doi":"10.1007/s00281-022-00947-3","DOIUrl":"https://doi.org/10.1007/s00281-022-00947-3","url":null,"abstract":"Parkinson's disease (PD) is the second most common neurodegenerative disorder which affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies and Lewy neurites caused by α-synuclein aggregation, and neuroinflammation in the brain. The prodromal phase happens years before the onset of PD during which time many patients show gastro-intestinal symptoms. These symptoms are in support of Braak's theory and model where pathological α-synuclein propagates from the gut to the brain. Importantly, immune responses play a determinant role in the pathogenesis of Parkinson's disease. The innate immune responses triggered by microglia can cause neuronal death and disease progression. In addition, T cells infiltrate into the brains of PD patients and become involved in the adaptive immune responses. Interestingly, α-synuclein is associated with both innate and adaptive immune responses by directly interacting with microglia and T cells. Here, we give a detailed review of the immunobiology of Parkinson's disease, focusing on the role α-synuclein in the gut-brain axis hypothesis, the innate and adaptive immune responses involved in the disease, and current treatments.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 5","pages":"659-672"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9232668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Metabolic regulation and function of T helper cells in neuroinflammation. T辅助细胞在神经炎症中的代谢调节和功能。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 Epub Date: 2022-09-06 DOI: 10.1007/s00281-022-00959-z

Martina Spiljar, Vijay K Kuchroo

{"title":"Metabolic regulation and function of T helper cells in neuroinflammation.","authors":"Martina Spiljar, Vijay K Kuchroo","doi":"10.1007/s00281-022-00959-z","DOIUrl":"https://doi.org/10.1007/s00281-022-00959-z","url":null,"abstract":"Neuroinflammatory conditions such as multiple sclerosis (MS) are initiated by pathogenic immune cells invading the central nervous system (CNS). Autoreactive CD4+ T helper cells are critical players that orchestrate the immune response both in MS and in other neuroinflammatory autoimmune diseases including animal models that have been developed for MS. T helper cells are classically categorized into different subsets, but heterogeneity exists within these subsets. Untangling the more complex regulation of these subsets will clarify their functional roles in neuroinflammation. Here, we will discuss how differentiation, immune checkpoint pathways, transcriptional regulation and metabolic factors determine the function of CD4+ T cell subsets in CNS autoimmunity. T cells rely on metabolic reprogramming for their activation and proliferation to meet bioenergetic demands. This includes changes in glycolysis, glutamine metabolism and polyamine metabolism. Importantly, these pathways were recently also implicated in the fine tuning of T cell fate decisions during neuroinflammation. A particular focus of this review will be on the Th17/Treg balance and intra-subset functional states that can either promote or dampen autoimmune responses in the CNS and thus affect disease outcome. An increased understanding of factors that could tip CD4+ T cell subsets and populations towards an anti-inflammatory phenotype will be critical to better understand neuroinflammatory diseases and pave the way for novel treatment paradigms.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":" ","pages":"581-598"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40353826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma. 诱导T细胞介导的抗胶质母细胞瘤免疫的概念框架。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00945-5

Sascha Marx, Anze Godicelj, Kai W Wucherpfennig

{"title":"A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma.","authors":"Sascha Marx, Anze Godicelj, Kai W Wucherpfennig","doi":"10.1007/s00281-022-00945-5","DOIUrl":"https://doi.org/10.1007/s00281-022-00945-5","url":null,"abstract":"Glioblastoma is a highly aggressive brain tumor with limited treatment options. Several major challenges have limited the development of novel therapeutics, including the extensive heterogeneity of tumor cell states within each glioblastoma and the ability of glioma cells to diffusely infiltrate into neighboring healthy brain tissue, including the contralateral hemisphere. A T cell-mediated immune response could deal with these challenges based on the ability of polyclonal T cell populations to recognize diverse tumor antigens and perform surveillance throughout tissues. Here we will discuss the major pathways that inhibit T cell-mediated immunity against glioblastoma, with an emphasis on receptor-ligand systems by which glioma cells and recruited myeloid cells inhibit T cell function. A related challenge is that glioblastomas tend to be poorly infiltrated by T cells, which is not only caused by inhibitory molecular pathways but also currently utilized drugs, in particular high-dose corticosteroids that kill activated, proliferating T cells. We will discuss innovative approaches to induce glioblastoma-directed T cell responses, including neoantigen-based vaccines and sophisticated CAR T cell approaches that can target heterogeneous glioblastoma cell populations. Finally, we will propose a conceptual framework for the future development of T cell-based immunotherapies for glioblastoma.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 5","pages":"697-707"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942346/pdf/nihms-1873680.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10753769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Correction to: MAIT cells in liver inflammation and fibrosis. 更正:肝脏炎症和纤维化中的MAIT细胞。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00956-2

Hema Mehta, Martin Joseph Lett, Paul Klenerman, Magdalena Filipowicz Sinnreich

引用次数: 0

Inflammatory Responses After Ischemic Stroke. 缺血性卒中后的炎症反应。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00943-7

Jonathan Howard DeLong, Sarah Naomi Ohashi, Kevin Charles O'Connor, Lauren Hachmann Sansing

引用次数: 29