Seminars in Immunopathology最新文献_第10页

A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma. 诱导T细胞介导的抗胶质母细胞瘤免疫的概念框架。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00945-5

Sascha Marx, Anze Godicelj, Kai W Wucherpfennig

{"title":"A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma.","authors":"Sascha Marx, Anze Godicelj, Kai W Wucherpfennig","doi":"10.1007/s00281-022-00945-5","DOIUrl":"https://doi.org/10.1007/s00281-022-00945-5","url":null,"abstract":"Glioblastoma is a highly aggressive brain tumor with limited treatment options. Several major challenges have limited the development of novel therapeutics, including the extensive heterogeneity of tumor cell states within each glioblastoma and the ability of glioma cells to diffusely infiltrate into neighboring healthy brain tissue, including the contralateral hemisphere. A T cell-mediated immune response could deal with these challenges based on the ability of polyclonal T cell populations to recognize diverse tumor antigens and perform surveillance throughout tissues. Here we will discuss the major pathways that inhibit T cell-mediated immunity against glioblastoma, with an emphasis on receptor-ligand systems by which glioma cells and recruited myeloid cells inhibit T cell function. A related challenge is that glioblastomas tend to be poorly infiltrated by T cells, which is not only caused by inhibitory molecular pathways but also currently utilized drugs, in particular high-dose corticosteroids that kill activated, proliferating T cells. We will discuss innovative approaches to induce glioblastoma-directed T cell responses, including neoantigen-based vaccines and sophisticated CAR T cell approaches that can target heterogeneous glioblastoma cell populations. Finally, we will propose a conceptual framework for the future development of T cell-based immunotherapies for glioblastoma.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 5","pages":"697-707"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942346/pdf/nihms-1873680.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10753769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Inflammatory Responses After Ischemic Stroke. 缺血性卒中后的炎症反应。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00943-7

Jonathan Howard DeLong, Sarah Naomi Ohashi, Kevin Charles O'Connor, Lauren Hachmann Sansing

引用次数: 29

The aging immune system in Alzheimer's and Parkinson's diseases. 阿尔茨海默病和帕金森病中衰老的免疫系统

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 Epub Date: 2022-05-03 DOI: 10.1007/s00281-022-00944-6

Kelsey S Heavener, Elizabeth M Bradshaw

引用次数: 9

Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries. 从18世纪到21世纪神经免疫的直觉。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 DOI: 10.1007/s00281-022-00948-2

Mytien Nguyen, Noah W Palm

{"title":"Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries.","authors":"Mytien Nguyen, Noah W Palm","doi":"10.1007/s00281-022-00948-2","DOIUrl":"https://doi.org/10.1007/s00281-022-00948-2","url":null,"abstract":"In the past two decades, work on the microbiota-gut-brain axis has led to a renewed appreciation for the interconnectedness between body systems in both clinical and scientific circles. In the USA alone, millions of adults are burdened with non-communicable chronic diseases whose putative etiologies were previously thought to be restricted to either the gut or brain, such as inflammatory bowel disease, irritable bowel syndrome, Parkinson's and Alzheimer's disease, and autism spectrum disorder. However, the recent explosion of research into the impacts of the gut microbiome on diverse aspects of human health has revealed the potentially critical importance of reciprocal interactions between the gut microbiota, the immune system, and the brain in diverse diseases and disorders. In this review, we revisit the history of gut-brain interactions in science and medicine, which dates back to at least the eighteenth century, and outline how concepts in this field have shifted and evolved across eras. Next, we highlight the modern resurgence of gut-brain axis research, focusing on neuro-immune-microbiota interactions and recent progress towards a mechanistic understanding of the diverse impacts of the microbiome on human health. Finally, we offer a forward-looking perspective on the future of microbiota-gut-brain research, which may eventually reveal new paths towards the treatment of diverse diseases influenced by the complex connections between the microbiota and the brain.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 5","pages":"569-579"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9519704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection. HIV-1 的神经发病机制：从急性感染到长期感染的整个过程中获得的启示。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-09-01 Epub Date: 2022-07-26 DOI: 10.1007/s00281-022-00953-5

Lauren Killingsworth, Serena Spudich

{"title":"Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection.","authors":"Lauren Killingsworth, Serena Spudich","doi":"10.1007/s00281-022-00953-5","DOIUrl":"10.1007/s00281-022-00953-5","url":null,"abstract":"This review outlines the neuropathogenesis of HIV, from initial HIV entry into the central nervous system (CNS) to chronic infection, focusing on key advancements in the last 5 years. Discoveries regarding acute HIV infection reveal timing and mechanisms of early HIV entry and replication in the CNS, early inflammatory responses, and establishment of genetically distinct viral reservoirs in the brain. Recent studies additionally explore how chronic HIV infection is maintained in the CNS, examining how the virus remains in a latent \"hidden\" state in diverse cells in the brain, and how this leads to sustained pathological inflammatory responses. Despite viral suppression with antiretroviral therapy, HIV can persist and even replicate in the CNS, and associate with ongoing neuropathology including CD8 + T-lymphocyte mediated encephalitis. Crucial investigation to advance our understanding of the immune mechanisms that both control viral infection and lead to pathological consequences in the brain is necessary to develop treatments to optimize long-term neurologic health in people living with HIV.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 5","pages":"709-724"},"PeriodicalIF":9.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126949/pdf/nihms-1864065.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10536669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acids and their receptors: modulators and therapeutic targets in liver inflammation. 胆汁酸及其受体:肝脏炎症的调节剂和治疗靶点。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-07-01 DOI: 10.1007/s00281-022-00935-7

Anna Bertolini, Romina Fiorotto, Mario Strazzabosco

引用次数: 35

How genetic risk contributes to autoimmune liver disease. 遗传风险如何导致自身免疫性肝病

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2022-07-01 Epub Date: 2022-06-01 DOI: 10.1007/s00281-022-00950-8

David Ellinghaus

{"title":"How genetic risk contributes to autoimmune liver disease.","authors":"David Ellinghaus","doi":"10.1007/s00281-022-00950-8","DOIUrl":"10.1007/s00281-022-00950-8","url":null,"abstract":"Genome-wide association studies (GWAS) for autoimmune hepatitis (AIH) and GWAS/genome-wide meta-analyses (GWMA) for primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) have been successful over the past decade, identifying about 100 susceptibility loci in the human genome, with strong associations with the HLA locus and many susceptibility variants outside the HLA locus with relatively low risk. However, identifying causative variants and genes and determining their effects on liver cells and their immunological microenvironment is far from trivial. Polygenic risk scores (PRSs) based on current genome-wide data have limited potential to predict individual disease risk. Interestingly, results of mediated expression score regression analysis provide evidence that a substantial portion of gene expression at susceptibility loci is mediated by genetic risk variants, in contrast to many other complex diseases. Genome- and transcriptome-wide comparisons between AIH, PBC, and PSC could help to better delineate the shared inherited component of autoimmune liver diseases (AILDs), and statistical fine-mapping, chromosome X-wide association testing, and genome-wide in silico drug screening approaches recently applied to GWMA data from PBC could potentially be successfully applied to AIH and PSC. Initial successes through single-cell RNA sequencing (scRNA-seq) experiments in PBC and PSC now raise high hopes for understanding the impact of genetic risk variants in the context of liver-resident immune cells and liver cell subpopulations, and for bridging the gap between genetics and disease.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"397-410"},"PeriodicalIF":7.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48176522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target. 胆管病变的细胞衰老:免疫病理的驱动因素和新的治疗靶点。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-07-01 DOI: 10.1007/s00281-022-00909-9

Christy E Trussoni, Steven P O'Hara, Nicholas F LaRusso

引用次数: 17

Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease 实现自身免疫性肝病有效调节性T细胞治疗的挑战和机遇

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2022-05-31 DOI: 10.1007/s00281-022-00940-w

N. Richardson, G. Wootton, A. Bozward, Y. Oo

引用次数: 11

MAIT cells in liver inflammation and fibrosis MAIT细胞在肝脏炎症和纤维化中的作用