Seminars in Immunopathology最新文献_第9页

Intracellular galectin interactions in health and disease. 健康和疾病中细胞内 galectin 的相互作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-07-11 DOI: 10.1007/s00281-024-01010-z

Ralf Jacob, Lena-Sophie Gorek

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引用次数: 0

Publisher Correction: Epithelial recognition and elimination against aberrant cells 出版商更正：上皮细胞识别和消除异常细胞

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-04-24 DOI: 10.1007/s00281-024-01009-6

Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama

引用次数: 0

Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells 第 3 组先天性淋巴细胞调控的疾病发病机制和屏障功能

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-02-02 DOI: 10.1007/s00281-024-01000-1

Ayana Mori, Hiroshi Ohno, Naoko Satoh-Takayama

{"title":"Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells","authors":"Ayana Mori, Hiroshi Ohno, Naoko Satoh-Takayama","doi":"10.1007/s00281-024-01000-1","DOIUrl":"https://doi.org/10.1007/s00281-024-01000-1","url":null,"abstract":"The mucosal surface is in constant contact with foreign antigens and is regulated by unique mechanisms that are different from immune responses in the peripheral organs. For the last several decades, only adaptive immune cells such as helper T (Th) cells, Th1, Th2, or Th17 were targeted to study a wide variety of immune responses in the mucosal tissues. However, since their discovery, innate lymphoid cells (ILCs) have been attracting attention as a unique subset of immune cells that provide border defense with various functions and tissue specificity. ILCs are classified into different groups based on cell differentiation and functions. Group 3 innate lymphoid cells (ILC3s) are particularly in close proximity to mucosal surfaces and therefore have the opportunity to be exposed to a variety of bacteria including pathogenic bacteria. In recent years, studies have also provided much evidence that ILC3s contribute to disease pathogenesis as well as the defense of mucosal surfaces by rapidly responding to pathogens and coordinating other immune cells. As the counterpart of helper T cells, ILC3s together with other ILC subsets establish the immune balance between adaptive and innate immunity in protecting us from invasion or encounter with non-self-antigens for maintaining a complex homeostasis. In this review, we summarize recent advances in our understanding of ILCs, with a particular focus on the function of ILC3s in their involvement in bacterial infection and disease pathogenesis.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"14 1","pages":""},"PeriodicalIF":9.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity 糖蛋白 2 是炎症与免疫之间粘膜平衡的肠道守门员

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-03 DOI: 10.1007/s00281-023-00999-z

引用次数: 0

Causes and costs of global COVID-19 vaccine inequity. 全球新冠肺炎疫苗不公平的原因和代价。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-10-23 DOI: 10.1007/s00281-023-00998-0

Maddalena Ferranna

引用次数: 0

Physiological and immunological barriers in the lung. 肺部的生理和免疫屏障。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2024-03-07 DOI: 10.1007/s00281-024-01003-y

Takahiro Kageyama, Takashi Ito, Shigeru Tanaka, Hiroshi Nakajima

引用次数: 0

Epithelial recognition and elimination against aberrant cells. 上皮细胞识别和消除异常细胞。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2024-02-27 DOI: 10.1007/s00281-024-01001-0

Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama

{"title":"Epithelial recognition and elimination against aberrant cells.","authors":"Shiyu Ayukawa, Nagisa Kamoshita, Takeshi Maruyama","doi":"10.1007/s00281-024-01001-0","DOIUrl":"10.1007/s00281-024-01001-0","url":null,"abstract":"Epithelial cells, which are non-immune cells, not only function as a physical defence barrier but also continuously monitor and eliminate aberrant epithelial cells in their vicinity. In other words, it has become evident that epithelial cells possess immune cell-like functions. In fact, recent research has revealed that epithelial cells recognise the Major Histocompatibility Complex I (MHC-I) of aberrant cells as a mechanism for surveillance. This cellular defence mechanism of epithelial cells probably detects aberrant cells more promptly than the conventional immune response, making it a novel and primary biological defence. Furthermore, there is the potential for this new immune-like biological defence mechanism to establish innovative treatment for disease prevention, leading to increasing anticipation for its future medical applications. In this review, we aim to summarise the recognition and attack mechanisms of aberrant cells by epithelial cells in mammals, with a particular focus on the field of cancer. Additionally, we discuss the potential therapeutic applications of epithelial cell-based defence against cancer, including novel prophylactic treatment methods based on molecular mechanisms.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":" ","pages":"521-532"},"PeriodicalIF":11.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The overlooked bacterial pandemic. 被忽视的细菌大流行

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-12-11 DOI: 10.1007/s00281-023-00997-1

Danilo Gomes Moriel, Diego Piccioli, Maria Michelina Raso, Mariagrazia Pizza

引用次数: 0

The role of vaccines in the COVID-19 pandemic: what have we learned? 疫苗在 COVID-19 大流行中的作用：我们学到了什么？

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-07-12 DOI: 10.1007/s00281-023-00996-2

Florian Krammer

引用次数: 0

Sex differences in the inflammatory response to stroke. 中风炎症反应的性别差异。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 Epub Date: 2022-11-10 DOI: 10.1007/s00281-022-00969-x

Muhammad Bilal Tariq, Juneyoung Lee, Louise D McCullough

{"title":"Sex differences in the inflammatory response to stroke.","authors":"Muhammad Bilal Tariq, Juneyoung Lee, Louise D McCullough","doi":"10.1007/s00281-022-00969-x","DOIUrl":"10.1007/s00281-022-00969-x","url":null,"abstract":"Ischemic stroke is a leading cause of morbidity and mortality and disproportionally affects women, in part due to their higher longevity. Older women have poorer outcomes after stroke with high rates of cognitive deficits, depression, and reduced quality of life. Post-stroke inflammatory responses are also sexually dimorphic and drive differences in infarct size and recovery. Factors that influence sex-specific immune responses can be both intrinsic and extrinsic. Differences in gonadal hormone exposure, sex chromosome compliment, and environmental/social factors can drive changes in transcriptional and metabolic profiles. In addition, how these variables interact, changes across the lifespan. After the onset of ischemic injury, necrosis and apoptosis occur, which activate microglia and other glial cells within the central nervous system, promoting the release of cytokines and chemokines and neuroinflammation. Cells involved in innate and adaptive immune responses also have dual functions after stroke as they can enhance inflammation acutely, but also contribute to suppression of the inflammatory cascade and later repair. In this review, we provide an overview of the current literature on sex-specific inflammatory responses to ischemic stroke. Understanding these differences is critical to identifying therapeutic options for both men and women.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"295-313"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10064719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0