Seminars in Immunopathology最新文献_第2页

Galectin-1 and galectin-3 in male reproduction - impact in health and disease. 半乳糖凝集素-1和半乳糖凝集素-3在男性生殖中的作用——对健康和疾病的影响。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2025-01-02 DOI: 10.1007/s00281-024-01032-7

Monika Fijak, Hiba Hasan, Andreas Meinhardt

{"title":"Galectin-1 and galectin-3 in male reproduction - impact in health and disease.","authors":"Monika Fijak, Hiba Hasan, Andreas Meinhardt","doi":"10.1007/s00281-024-01032-7","DOIUrl":"10.1007/s00281-024-01032-7","url":null,"abstract":"The formation and differentiation of mature, motile male germ cells, which can fertilize the egg and ensure successful implantation and development of a healthy embryo, are essential functions of the testis and epididymis. Spermatogenesis is a complex, multistep process that results in the formation of motile haploid gametes, requiring an immunoregulatory environment to maintain tolerance to developing neo-antigens. Different cell types (Sertoli cells, macrophages), immunoregulatory factors and tolerance mechanisms are involved. In this context, possible effects of galectins on the immunoregulatory functions and fertilization ability of male germ cells are postulated. Galectins are pleiotropic lectins involved in the homeostasis, modulation of immune responses and pathological processes. Despite the well-recognized role of galectins in female reproduction, the functions of galectins in the male reproductive organs, particularly the testis and epididymis, remain largely unexplored. Among the galectins, galectin-1 and galectin-3 are the best-studied in these organs. This review summarizes the current knowledge of the cellular expression and the roles of galectin-1 and galectin-3 in testis and epididymis and discusses their functions in spermatogenesis, steroidogenesis, epididymal maturation of spermatozoa and inflammatory response.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"6"},"PeriodicalIF":7.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation. 胎母微嵌合在（造血干细胞）移植中的临床意义。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-12-07 DOI: 10.1007/s00281-024-01028-3

Anne Kruchen, Boris Fehse, Ingo Müller

{"title":"Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.","authors":"Anne Kruchen, Boris Fehse, Ingo Müller","doi":"10.1007/s00281-024-01028-3","DOIUrl":"10.1007/s00281-024-01028-3","url":null,"abstract":"Toleration of a semi-allogeneic fetus in the mother's uterus as well as tolerance after allogeneic hematopoietic stem cell transplantation (HSCT) appear to share some immunologic concepts. The existence of microchimeric cells, and the original idea of a bidirectional cell trafficking between mother and child during pregnancy have been known for decades. Today, origins and mechanisms of persistence of microchimeric cells are intensively being elucidated. Both, the translation of the phenomenon of feto-maternal immune tolerance to donor choice or prevention of graft-versus-host disease (GvHD) in HSCT, and the implications of microchimeric cells in and for HSCT are highly intriguing. Yet, differences in detection methods of microchimeric cells, as well as in transplantation protocols impede the comparison of larger cohorts, and limit potential clinical advice. Still, matching of non-inherited maternal antigens (NIMA), which are expressed on maternal microchimeric cells, demonstrated a strong association with decreased risk for the development of acute GvHD in the context of various transplantation strategies. Despite the fact that advances in graft manipulation and immunosuppression ameliorated the safety and outcome after HSCT, NIMA-matching retained a beneficial role in selection of sibling, child, or maternal donors, as well as for cord blood units. Recent findings indicate the existence of a microchimeric stem cell niche, in which only one dominant microchimeric cell population of only one semi-allogeneic origin persists at a time. This implies that studies regarding the impact of (maternal and fetal) microchimerism (MC) on clinical outcome of HSCT should combine analysis of NIMA and direct detection of microchimeric cells from donor and recipient on the verge of HSCT to be efficiently conclusive.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"4"},"PeriodicalIF":7.9,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into intrauterine adhesions. 宫内粘连的机理研究。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-11-29 DOI: 10.1007/s00281-024-01030-9

Guangfeng Zhao, Yali Hu

引用次数: 0

The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation. 粘膜屏障系统在维持肠道共生以防止肠道炎症中的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-11-26 DOI: 10.1007/s00281-024-01026-5

Ryu Okumura, Kiyoshi Takeda

{"title":"The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation.","authors":"Ryu Okumura, Kiyoshi Takeda","doi":"10.1007/s00281-024-01026-5","DOIUrl":"10.1007/s00281-024-01026-5","url":null,"abstract":"In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules can be classified into two groups based on their functions: those that exhibit bactericidal activity through chemical reactions, such as antimicrobial peptides, and those that physically hinder bacterial invasion, like mucins, which lack bactericidal properties. In the small intestine, where Paneth cells specialize in producing antimicrobial peptides, the chemical barrier molecules primarily inhibit bacterial growth. In contrast, in the large intestine, where Paneth cells are absent, allowing bacterial growth, the primary defense mechanism is the physical barrier, mainly composed of mucus, which controls bacterial movement and prevents their invasion of intestinal tissues. The expression of these barrier molecules is regulated by metabolites produced by bacteria in the intestinal lumen and cytokines produced by immune cells in the lamina propria. This regulation establishes a defense mechanism that adapts to changes in the intestinal environment, such as alterations in gut microbial composition and the presence of pathogenic bacterial infections. Consequently, when the integrity of the gut mucosal barrier is compromised, commensal bacteria and pathogenic microorganisms from outside the body can invade intestinal tissues, leading to conditions such as intestinal inflammation, as observed in cases of inflammatory bowel disease.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"2"},"PeriodicalIF":7.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of mucosal IgA antibodies as novel therapies to enhance mucosal barriers. 粘膜 IgA 抗体作为增强粘膜屏障的新型疗法的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-11-20 DOI: 10.1007/s00281-024-01027-4

Peng Gao, Naoki Morita, Reiko Shinkura

引用次数: 0

Glycan diversity in ovarian cancer: Unraveling the immune interplay and therapeutic prospects. 卵巢癌中的糖多样性：揭示免疫相互作用和治疗前景。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-10-21 DOI: 10.1007/s00281-024-01025-6

Gerrit Wolters-Eisfeld, Leticia Oliveira-Ferrer

{"title":"Glycan diversity in ovarian cancer: Unraveling the immune interplay and therapeutic prospects.","authors":"Gerrit Wolters-Eisfeld, Leticia Oliveira-Ferrer","doi":"10.1007/s00281-024-01025-6","DOIUrl":"10.1007/s00281-024-01025-6","url":null,"abstract":"Ovarian cancer remains a formidable challenge in oncology due to its late-stage diagnosis and limited treatment options. Recent research has revealed the intricate interplay between glycan diversity and the immune microenvironment within ovarian tumors, shedding new light on potential therapeutic strategies. This review seeks to investigate the complex role of glycans in ovarian cancer and their impact on the immune response. Glycans, complex sugar molecules decorating cell surfaces and secreted proteins, have emerged as key regulators of immune surveillance in ovarian cancer. Aberrant glycosylation patterns can promote immune evasion by shielding tumor cells from immune recognition, enabling disease progression. Conversely, certain glycan structures can modulate the immune response, leading to either antitumor immunity or immune tolerance. Understanding the intricate relationship between glycan diversity and immune interactions in ovarian cancer holds promise for the development of innovative therapeutic approaches. Immunotherapies that target glycan-mediated immune evasion, such as glycan-based vaccines or checkpoint inhibitors, are under investigation. Additionally, glycan profiling may serve as a diagnostic tool for patient stratification and treatment selection. This review underscores the emerging importance of glycan diversity in ovarian cancer, emphasizing the potential for unraveling immune interplay and advancing tailored therapeutic prospects for this devastating disease.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 6","pages":"16"},"PeriodicalIF":7.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142474222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration. 透明质酸及其化学衍生物在免疫平衡、癌症和组织再生中的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-09-06 DOI: 10.1007/s00281-024-01024-7

Paolo Rosales, Daiana Vitale, Antonella Icardi, Ina Sevic, Laura Alaniz

引用次数: 0

The fetal programming effect of maternal immune activation (MIA) on the offspring's immune system. 母体免疫激活（MIA）对后代免疫系统的胎儿编程效应。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-30 DOI: 10.1007/s00281-024-01023-8

Naomi Hofsink, Lucianne Groenink, Torsten Plösch

{"title":"The fetal programming effect of maternal immune activation (MIA) on the offspring's immune system.","authors":"Naomi Hofsink, Lucianne Groenink, Torsten Plösch","doi":"10.1007/s00281-024-01023-8","DOIUrl":"10.1007/s00281-024-01023-8","url":null,"abstract":"The first 1000 days of life is a critical period of development in which adverse circumstances can have long-term consequences for the child's health. Maternal immune activation is associated with increased risk of neurodevelopmental disorders in the child. Aberrant immune responses have been reported in individuals with neurodevelopmental disorders. Moreover, lasting effects of maternal immune activation on the offspring's immune system have been reported. Taken together, this indicates that the effect of maternal immune activation is not limited to the central nervous system. Here, we explore the impact of maternal immune activation on the immune system of the offspring. We first describe the development of the immune system and provide an overview of reported alterations in the cytokine profiles, immune cell profiles, immune cell function, and immune induction in pre-clinical models. Additionally, we highlight recent research on the impact of maternal COVID-19 exposure on the neonatal immune system and the potential health consequences for the child. Our review shows that maternal immune activation alters the offspring's immune system under certain conditions, but the reported effects are conflicting and inconsistent. In general, epigenetic modifications are considered the mechanism for fetal programming. The available data was insufficient to identify specific pathways that may contribute to immune programming. As a consequence of the COVID-19 pandemic, more research now focuses on the possible health effects of maternal immune activation on the offspring. Future research addressing the offspring's immune response to maternal immune activation can elucidate specific pathways that contribute to fetal immune programming and the long-term health effects for the offspring.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 5","pages":"14"},"PeriodicalIF":7.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits. 成功的标志：疫苗诱导的皮肤疤痕形成对卡介苗和天花疫苗相关临床益处的作用。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-26 DOI: 10.1007/s00281-024-01022-9

Ole Bæk, Frederik Schaltz-Buchholzer, Anita Campbell, Nelly Amenyogbe, James Campbell, Peter Aaby, Christine Stabell Benn, Tobias R Kollmann

引用次数: 0

Advances in manufacturing chimeric antigen receptor immune cell therapies. 制造嵌合抗原受体免疫细胞疗法的进展。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2024-08-16 DOI: 10.1007/s00281-024-01019-4

Apoorva Ramamurthy, Anna Tommasi, Krishanu Saha

{"title":"Advances in manufacturing chimeric antigen receptor immune cell therapies.","authors":"Apoorva Ramamurthy, Anna Tommasi, Krishanu Saha","doi":"10.1007/s00281-024-01019-4","DOIUrl":"10.1007/s00281-024-01019-4","url":null,"abstract":"Biomedical research has witnessed significant strides in manufacturing chimeric antigen receptor T cell (CAR-T) therapies, marking a transformative era in cellular immunotherapy. Nevertheless, existing manufacturing methods for autologous cell therapies still pose several challenges related to cost, immune cell source, safety risks, and scalability. These challenges have motivated recent efforts to optimize process development and manufacturing for cell therapies using automated closed-system bioreactors and models created using artificial intelligence. Simultaneously, non-viral gene transfer methods like mRNA, CRISPR genome editing, and transposons are being applied to engineer T cells and other immune cells like macrophages and natural killer cells. Alternative sources of primary immune cells and stem cells are being developed to generate universal, allogeneic therapies, signaling a shift away from the current autologous paradigm. These multifaceted innovations in manufacturing underscore a collective effort to propel this therapeutic approach toward broader clinical adoption and improved patient outcomes in the evolving landscape of cancer treatment. Here, we review current CAR immune cell manufacturing strategies and highlight recent advancements in cell therapy scale-up, automation, process development, and engineering.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"46 5","pages":"12"},"PeriodicalIF":7.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0