Seminars in Immunopathology最新文献_第3页

Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma. 丁酸重塑免疫-表观遗传-肠-肺轴：哮喘的新机制和治疗前景。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2026-04-06 DOI: 10.1007/s00281-026-01069-w

Yuqia Xie, Guochun Huang, Jun Zhao, Zhicheng Yuan, Hangyu Li, Jingyi Deng, Daichi Chen, Wenlu Zhu, Gonghua Huang, Yuanhui Li, Suidong Ouyang

{"title":"Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma.","authors":"Yuqia Xie, Guochun Huang, Jun Zhao, Zhicheng Yuan, Hangyu Li, Jingyi Deng, Daichi Chen, Wenlu Zhu, Gonghua Huang, Yuanhui Li, Suidong Ouyang","doi":"10.1007/s00281-026-01069-w","DOIUrl":"10.1007/s00281-026-01069-w","url":null,"abstract":"Butyrate, a major microbial metabolite derived from dietary fiber fermentation, has emerged as a key regulator in the pathogenesis and treatment of asthma. It modulates the functions of dendritic cells, macrophages, and T cells, thereby reshaping the inflammatory microenvironment. In parallel, butyrate influences the transcriptional activity of inflammation-related genes through epigenetic mechanisms such as histone acetylation, DNA demethylation, and miRNA regulation. Notably, butyrate mediates long-range immune modulation via the gut-lung axis, linking intestinal microbial homeostasis to pulmonary inflammation. This review summarizes current advances in understanding the central role of butyrate within the immune-epigenetic-gut-lung network and discusses emerging therapeutic strategies based on microbiota modulation and targeted delivery systems. Regulation of the butyrate pathway offers new insights into the complex pathogenesis of asthma and potential avenues for innovative therapeutic development.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"48 1","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the intestinal microbiota on T_H17 cell-derived cytokines in the context of intestinal inflammation. 肠道微生物群对肠道炎症背景下TH17细胞源性细胞因子的影响

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2026-04-02 DOI: 10.1007/s00281-026-01070-3

Justus Neuendorff, Samuel Huber, Penelope Pelczar

{"title":"Effect of the intestinal microbiota on TH17 cell-derived cytokines in the context of intestinal inflammation.","authors":"Justus Neuendorff, Samuel Huber, Penelope Pelczar","doi":"10.1007/s00281-026-01070-3","DOIUrl":"10.1007/s00281-026-01070-3","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract (GI tract). Despite extensive research, its exact pathogenesis remains elusive. However, multiple factors are thought to be involved in the onset and progression of IBD. Aside from genetic risk factors, microbial dysbiosis, environmental cues, defects in the epithelial barrier, as well as a dysregulated intestinal immune response, are critical players driving a vicious cycle, which ultimately results in chronic disease. An orchestrated interaction between the intestinal microbiota and the immune response, especially TH17 cells, is critical for maintaining and re-establishing intestinal homeostasis. Nonetheless, a misguided interaction contributes to the pathogenesis of IBD. Indeed, depending on the microenvironment, intestinal TH17 cells possess dual properties. Either they act to control the inflammatory response, or they acquire pro-inflammatory features promoting the development of intestinal pathology. This context-dependent phenotype of TH17 cells has recently been associated with the microbiota composition, which shapes the inflammatory milieu of the gut. To establish precision immunomodulation as a therapeutic strategy for patients with IBD, it is critical to understand how intestinal microorganisms are involved in actively directing the dichotomous nature of TH17 cells and their cytokine products.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"48 1","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease. Paneth细胞作为上皮屏障防御的协调者和炎症性肠病的新治疗靶点。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2026-03-16 DOI: 10.1007/s00281-026-01068-x

Lena Erkert, Lea-Maxie Haag, Christoph Becker

{"title":"Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease.","authors":"Lena Erkert, Lea-Maxie Haag, Christoph Becker","doi":"10.1007/s00281-026-01068-x","DOIUrl":"10.1007/s00281-026-01068-x","url":null,"abstract":"First described by Joseph Paneth in 1888 in the small intestine, particularly in the crypts of Lieberkühn, Paneth cells have since emerged as a critical subtype of intestinal epithelial cells (IECs), which together constitute the body’s largest interface with the external environment, continuously exposed to pathogens, dietary components, and toxins. Paneth cells represent a unique, long-lived secretory IEC population located at the crypt base, where they play indispensable roles in antimicrobial defense and stem cell niche maintenance. Their differentiation, positioning, and survival are governed by tightly regulated signaling networks, including the Wnt and Notch pathway. Although traditionally viewed as terminally differentiated, emerging evidence suggests Paneth cells possess a certain level of plasticity, enabling functional adaptation or dedifferentiation under stress or injury. These characteristics position Paneth cells as central regulators of intestinal homeostasis and epithelial barrier integrity. Over the last decades, accumulating evidence has established that Paneth cell dysfunction is closely linked to microbial dysbiosis and the development of inflammatory bowel disease (IBD), highlighting their contribution to disease pathogenesis. Recent discoveries on how Paneth cell dysfunction contributes to intestinal inflammation are uncovering new therapeutic approaches aimed at reestablishing Paneth cell homeostasis and alleviating IBD progression. In this review, we comprehensively summarize current knowledge on Paneth cell differentiation, function, and their role in gut host defense and epithelial barrier maintenance. We further discuss mechanisms by which Paneth cell dysfunction disrupts intestinal homeostasis, promoting IBD development, and highlight emerging therapeutic strategies that target Paneth cells to reestablish barrier integrity and restore gut health.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"48 1","pages":""},"PeriodicalIF":11.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging microbiome-directed therapies in inflammatory bowel disease: beyond diet modification and FMT. 新兴的微生物组导向治疗炎症性肠病：超越饮食改变和FMT。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-11-25 DOI: 10.1007/s00281-025-01066-5

Andrea Carolina Quiroga-Centeno, Konstantina Atanasova, Matthias Philip Ebert, Anne Kerstin Thomann, Wolfgang Reindl

{"title":"Emerging microbiome-directed therapies in inflammatory bowel disease: beyond diet modification and FMT.","authors":"Andrea Carolina Quiroga-Centeno, Konstantina Atanasova, Matthias Philip Ebert, Anne Kerstin Thomann, Wolfgang Reindl","doi":"10.1007/s00281-025-01066-5","DOIUrl":"10.1007/s00281-025-01066-5","url":null,"abstract":"Inflammatory bowel disease (IBD) is a multifactorial and heterogeneous disorder that remains challenging to manage. Growing evidence implicates the gut microbiome as a key player in IBD pathogenesis, with many patients displaying intestinal dysbiosis that can drive aberrant immune responses. Traditional microbiome-targeted interventions, such as dietary modifications, probiotics, and fecal microbiota transplantation (FMT), have yielded mixed and often temporary benefits in IBD. This shortcoming of broad-spectrum approaches underscores the need for more precise, personalized strategies that account for each patient's unique microbiota and disease phenotype. Recent advances in omics and bioengineering have catalyzed the development of emerging microbiome-directed therapies that move beyond these broad approaches. This narrative review highlights emerging microbiome-directed therapies that aim to restore gut homeostasis and mitigate inflammation in IBD. We critically evaluate the rationale and therapeutic potential of rationally designed bacterial consortia and genetically engineered bacteria, which represent next-generation probiotics tailored to complement deficient microbial functions or deliver anti-inflammatory agents in situ. We also expand the discussion to underexplored microbiome constituents - archaea, protists, bacteriophages, and fungi - highlighting their roles in IBD and potential as therapeutic targets. Finally, we discuss the key advances and ongoing challenges of these innovative approaches, from ecological stability and engraftment to safety and regulatory considerations.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"42"},"PeriodicalIF":11.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis. 微生物组的隐藏影响：坏死性小肠结肠炎炎症反应的临床前观察。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-11-24 DOI: 10.1007/s00281-025-01059-4

Briana M Peterson, Ina Rudloff, Nadia S Deen, Sara K Di Simone, Ramesh M Nataraja, Gergely Toldi, Maurizio Pacilli, Steven P Garrick, Steven X Cho, Marcel F Nold, Samuel C Forster, Claudia A Nold-Petry

{"title":"The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis.","authors":"Briana M Peterson, Ina Rudloff, Nadia S Deen, Sara K Di Simone, Ramesh M Nataraja, Gergely Toldi, Maurizio Pacilli, Steven P Garrick, Steven X Cho, Marcel F Nold, Samuel C Forster, Claudia A Nold-Petry","doi":"10.1007/s00281-025-01059-4","DOIUrl":"10.1007/s00281-025-01059-4","url":null,"abstract":"Necrotizing enterocolitis (NEC) is the most common surgical emergency in preterm infants; nonetheless, besides supportive measures, no treatment is available. NEC significantly increases length of hospitalization of preterm infants, causes severe morbidity and up to 70% mortality. Despite limited understanding of the underlying mechanisms, prematurity, dysbiosis and an underdeveloped immune system are known to increase the risks of developing NEC. The low weight of preterm infants (often < 2000 g) and unpredictable progression of NEC hinder clinical research; hence, most of our mechanistic understanding of NEC pathophysiology has arisen from animal models. Recent advances in bacterial genomic analyses highlighted the intestinal microbiome's key role in NEC, strengthening the concept that this disease results from an interaction between the patient's developing immune system and their microbiome. This notion is supported by the moderate effect of probiotics in preventing NEC. Here, we review the current knowledge on how the immune system interacts with the intestinal microbiome in early life, including in relation to NEC, describe the current evidence from cohort studies, clinical trials, in vivo and in vitro models used to study NEC, and methods to modulate the immune system and microbiome in early life. Knowledge on the early-life microbiome and immune system in health and diseases, including NEC, can be harnessed to develop novel and urgently needed immunomodulatory and microbiota-based therapeutics.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"41"},"PeriodicalIF":11.5,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Therapeutic mechanisms of exclusive enteral nutrition in crohn's disease. 纠正：单独肠内营养治疗克罗恩病的机制。

IF 9.2 2区医学

Seminars in Immunopathology Pub Date : 2025-11-11 DOI: 10.1007/s00281-025-01067-4

Tina Krammel, Jiatong Nie, Deborah Häcker, Tobias Schwerd, Doriane Aguanno, Dirk Haller

引用次数: 0

Systemic sclerosis: pathogenic mechanisms and their implications for treatment. 系统性硬化症：发病机制及其治疗意义。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-11-11 DOI: 10.1007/s00281-025-01065-6

Alain Lescoat, Valérie Lecureur, Johann E Gudjonsson, Dinesh Khanna

{"title":"Systemic sclerosis: pathogenic mechanisms and their implications for treatment.","authors":"Alain Lescoat, Valérie Lecureur, Johann E Gudjonsson, Dinesh Khanna","doi":"10.1007/s00281-025-01065-6","DOIUrl":"10.1007/s00281-025-01065-6","url":null,"abstract":"Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by a triad of pathogenic mechanisms, including: a) microvascular hyperreactivity secondary to endothelial dysfunction, b) dysregulated immune activation of both innate and adaptive immunity, with the production of autoantibodies targeting nuclear antigens (e.g., anticentromere antibodies, anti-RNA polymerase III antibodies, and anti-topoisomerase I antibodies), and c) fibrosis of the skin and internal organs, such as the lungs, due to excessive extracellular matrix deposits produced by dysregulated myofibroblasts. Skin involvement plays a crucial role in the detrimental impact of SSc on quality of life. Skin fibrosis in SSc is characterized by the progressive accumulation of extracellular matrix components, including collagen, in the dermis, and is associated with adipocyte atrophy in the hypodermis. Visceral manifestations include fibrotic interstitial lung disease (ILD), myocardial involvement, pulmonary arterial hypertension, gastrointestinal manifestations, and scleroderma renal crisis. These manifestations are key determinants of prognosis and significant contributors to mortality in SSc. This review will explore the clinical features of SSc, the existing subtypes based on different classification approaches (such as skin-driven classifications, autoantibodies, or molecular subsets), epidemiology, identified etiologies, pathogenesis, current standards of care, and a selection of potential therapeutic perspectives. This review will emphasize SSc-related skin manifestations, including their pathogenesis and treatment, while also discussing other organ manifestations.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"39"},"PeriodicalIF":11.5,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment. 坏疽性脓皮病：发病机制及其治疗意义。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-10-23 DOI: 10.1007/s00281-025-01064-7

Chiara Moltrasio, Maurizio Romagnuolo, Gianluca Tavoletti, Carlo Alberto Maronese, Angelo Valerio Marzano

{"title":"Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment.","authors":"Chiara Moltrasio, Maurizio Romagnuolo, Gianluca Tavoletti, Carlo Alberto Maronese, Angelo Valerio Marzano","doi":"10.1007/s00281-025-01064-7","DOIUrl":"10.1007/s00281-025-01064-7","url":null,"abstract":"Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune response, with an imbalance between pro-inflammatory and anti-inflammatory mediators, leading to neutrophil-driven inflammatory damage. Several immunosuppressants and immunomodulatory drugs are currently available for the treatment of PG, in combination with topical therapies, wound management and pain control strategies. Systemic corticosteroids and cyclosporine remain the first-line treatment options with the best evidence. However, in recent years, the rise of knowledge about different pathogenic mechanisms has led to a significant increase in studies attesting the efficacy and safety of biologic therapies including, among others, antagonists of tumour necrosis factor (TNF)-α and interleukin (IL)-23, becoming the drug of choice in specific clinical setting. Similarly, different small molecules such as JAK-STAT (Janus kinase/signal transducer and activator of transcription) inhibitors are showing promising results for the treatment of PG. We review established and emerging pathogenesis-driven treatments, also providing a therapeutic algorithm and informing future directions in the management of PG.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"38"},"PeriodicalIF":11.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12549756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between the microbiota and intestinal dendritic cells in IBD. IBD中微生物群与肠道树突状细胞之间的串扰。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-09-30 DOI: 10.1007/s00281-025-01062-9

Philine Letz, Samuel Huber, Lis N Velasquez

{"title":"Crosstalk between the microbiota and intestinal dendritic cells in IBD.","authors":"Philine Letz, Samuel Huber, Lis N Velasquez","doi":"10.1007/s00281-025-01062-9","DOIUrl":"10.1007/s00281-025-01062-9","url":null,"abstract":"Conventional dendritic cells (cDCs) play a pivotal role in orchestrating the delicate balance between immunity and tolerance within the gastrointestinal tract by interacting with other cell types, particularly T cells. Meanwhile, the microbiota is critical for the induction and modulation of the immune system in the gut and plays a key role in the function of cDCs. So far, the study of intestinal cDCs has been encumbered by their limited numbers and phenotypic overlap with other myeloid cells. Recent advancements in single-cell sequencing technology have helped define cDCs and their subsets, while also providing valuable insights into the contribution of cDCs to Inflammatory Bowel Disease (IBD). However, the exact role of cDCs in IBD remains unclear, particularly in terms of how the microbiota influences their function in this context. In this review, we summarize the functions of cDCs in the intestine and during IBD, and the role of the microbiota in cDC biology. We also describe the current limitations in the study of cDCs and the microbiota, as well as new methods for studying DC-T cell communications in vivo, which can help increase our understanding of the function of cDCs in the intestine and develop new therapeutic strategies against IBD.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"37"},"PeriodicalIF":11.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerating the uterus: translational advances in endometrial bioengineering and immunotherapeutics. 子宫再生：子宫内膜生物工程和免疫治疗的翻译进展。

IF 11.5 2区医学

Seminars in Immunopathology Pub Date : 2025-09-30 DOI: 10.1007/s00281-025-01063-8

Danbi Lee, Youn-Jung Kang, Haengseok Song

{"title":"Regenerating the uterus: translational advances in endometrial bioengineering and immunotherapeutics.","authors":"Danbi Lee, Youn-Jung Kang, Haengseok Song","doi":"10.1007/s00281-025-01063-8","DOIUrl":"10.1007/s00281-025-01063-8","url":null,"abstract":"Uterine disorders, such as thin endometrium and intrauterine adhesions, remain significant challenges in reproductive medicine, often leading to infertility and poor pregnancy outcomes. Recent advances in regenerative medicine and tissue engineering have led to the development of innovative therapeutic strategies aimed at restoring endometrial structure and function. Biomaterials play a central role in these advancements, serving not only as structural scaffolds and delivery vehicles for stem/progenitor cells and bioactive molecules but also as modulators of the tissue microenvironment by promoting angiogenesis and regulating immune responses. Mesenchymal stem cells from various sources, including female reproductive tissues, along with their extracellular vesicles, have demonstrated potential in promoting angiogenesis, reducing fibrosis, and modulating immune responses for endometrial repair. Additionally, platelet-rich plasma and a range of pharmacological agents-often with advanced drug delivery systems, such as nanocarriers-further contribute to endometrial regeneration. Engineered scaffolds, particularly those derived from decellularized extracellular matrix or fabricated using three-dimensional bioprinting technologies, closely mimic the biomechanical and biochemical properties of native endometrium. These scaffolds facilitate cellular engraftment and provide valuable platforms for in vitro modeling of endometrial physiology. The development of uterus-derived extracellular matrix scaffolds with immunologically compatible biomaterials and organoids marks a pivotal step toward reducing immune rejection and improving clinical applicability. This review highlights recent progress in biomaterial-based therapeutics for uterine regeneration and discusses the remaining challenges in shifting therapeutic paradigms of personalized and tissue-specific regenerative strategies.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"47 1","pages":"36"},"PeriodicalIF":11.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0