Seminars in Immunopathology最新文献_第6页

The role of vaccines in the COVID-19 pandemic: what have we learned? 疫苗在 COVID-19 大流行中的作用：我们学到了什么？

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2024-01-01 Epub Date: 2023-07-12 DOI: 10.1007/s00281-023-00996-2

Florian Krammer

引用次数: 0

Sex differences in the inflammatory response to stroke. 中风炎症反应的性别差异。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 Epub Date: 2022-11-10 DOI: 10.1007/s00281-022-00969-x

Muhammad Bilal Tariq, Juneyoung Lee, Louise D McCullough

{"title":"Sex differences in the inflammatory response to stroke.","authors":"Muhammad Bilal Tariq, Juneyoung Lee, Louise D McCullough","doi":"10.1007/s00281-022-00969-x","DOIUrl":"10.1007/s00281-022-00969-x","url":null,"abstract":"Ischemic stroke is a leading cause of morbidity and mortality and disproportionally affects women, in part due to their higher longevity. Older women have poorer outcomes after stroke with high rates of cognitive deficits, depression, and reduced quality of life. Post-stroke inflammatory responses are also sexually dimorphic and drive differences in infarct size and recovery. Factors that influence sex-specific immune responses can be both intrinsic and extrinsic. Differences in gonadal hormone exposure, sex chromosome compliment, and environmental/social factors can drive changes in transcriptional and metabolic profiles. In addition, how these variables interact, changes across the lifespan. After the onset of ischemic injury, necrosis and apoptosis occur, which activate microglia and other glial cells within the central nervous system, promoting the release of cytokines and chemokines and neuroinflammation. Cells involved in innate and adaptive immune responses also have dual functions after stroke as they can enhance inflammation acutely, but also contribute to suppression of the inflammatory cascade and later repair. In this review, we provide an overview of the current literature on sex-specific inflammatory responses to ischemic stroke. Understanding these differences is critical to identifying therapeutic options for both men and women.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"295-313"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10064719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the immunopathology of stroke: a comprehensive view on brain-immune interaction. 揭示脑卒中的免疫病理:脑免疫相互作用的综合观点。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-023-00995-3

Tim Magnus, Arthur Liesz

引用次数: 0

Role of alarmins in poststroke inflammation and neuronal repair. 警报器在脑卒中后炎症和神经元修复中的作用。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-022-00961-5

Seiichiro Sakai, Takashi Shichita

{"title":"Role of alarmins in poststroke inflammation and neuronal repair.","authors":"Seiichiro Sakai, Takashi Shichita","doi":"10.1007/s00281-022-00961-5","DOIUrl":"https://doi.org/10.1007/s00281-022-00961-5","url":null,"abstract":"Severe loss of cerebral blood flow causes hypoxia and glucose deprivation in the brain tissue, resulting in necrotic cell death in the ischemic brain. Several endogenous molecules, called alarmins or damage-associated molecular patterns (DAMPs), are extracellularly released from the dead cells to activate pattern recognition receptors (PRRs) in immune cells that infiltrate into ischemic brain tissue following the disruption of the blood-brain barrier (BBB) after stroke onset. The activated immune cells produce various inflammatory cytokines and chemokines, triggering sterile cerebral inflammation in the ischemic brain that causes further neuronal cell death. Poststroke inflammation is resolved within several days after stroke onset, and neurological functions are restored to some extent as neural repair occurs around peri-infarct neurons. Clearance of DAMPs from the injured brain is necessary for the resolution of poststroke inflammation. Neurons and glial cells also express PRRs and receive DAMP signaling. Although the role of PRRs in neural cells in the ischemic brain has not yet been clarified, the signaling pathway is likely to be contribute to stroke pathology and neural repair after ischemic stroke. This review describes the molecular dynamics, signaling pathways, and functions of DAMPs in poststroke inflammation and its resolution.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"427-435"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9693350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Thromboinflammatory challenges in stroke pathophysiology. 卒中病理生理学中的血栓炎性挑战。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-023-00994-4

R D Szepanowski, S Haupeltshofer, S E Vonhof, B Frank, C Kleinschnitz, A I Casas

{"title":"Thromboinflammatory challenges in stroke pathophysiology.","authors":"R D Szepanowski, S Haupeltshofer, S E Vonhof, B Frank, C Kleinschnitz, A I Casas","doi":"10.1007/s00281-023-00994-4","DOIUrl":"https://doi.org/10.1007/s00281-023-00994-4","url":null,"abstract":"Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon stroke. Similarly, the relevance of platelets and their tight crosstalk with a variety of immune cells highlights the relevance of this cell-cell interaction during microvascular dysfunction, neovascularization, and cellular adhesion. Ultimately, we provide an up-to-date overview of therapeutic approaches mechanistically targeting thromboinflammation currently under clinical translation, especially focusing on phase I to III clinical trials.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"389-410"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Differences in the post-stroke innate immune response between young and old. 年轻人和老年人中风后先天免疫反应的差异。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-023-00990-8

Mattia Gallizioli, Maria Arbaizar-Rovirosa, David Brea, Anna M Planas

{"title":"Differences in the post-stroke innate immune response between young and old.","authors":"Mattia Gallizioli, Maria Arbaizar-Rovirosa, David Brea, Anna M Planas","doi":"10.1007/s00281-023-00990-8","DOIUrl":"https://doi.org/10.1007/s00281-023-00990-8","url":null,"abstract":"Aging is associated to progressive changes impairing fundamental cellular and tissue functions, and the relationships amongst them through the vascular and immune systems. Aging factors are key to understanding the pathophysiology of stroke since they increase its risk and worsen its functional outcome. Most currently recognised hallmarks of aging are also involved in the cerebral responses to stroke. Notably, age-associated chronic low-grade inflammation is related to innate immune responses highlighted by induction of type-I interferon. The interferon program is prominent in microglia where it interrelates cell damage, danger signals, and phagocytosis with immunometabolic disturbances and inflammation. Microglia engulfment of damaged myelin and cell debris may overwhelm the cellular capacity for waste removal inducing intracellular lipid accumulation. Acute inflammation and interferon-stimulated gene expression are also typical features of acute stroke, where danger signal recognition by microglia trigger immunometabolic alterations underscored by lipid droplet biogenesis. Aging reduces the capacity to control these responses causing increased and persistent inflammation, metabolic dysregulation, and impaired cellular waste disposal. In turn, chronic peripheral inflammation during aging induces immunosenescence further worsening stroke-induced immunodepression, thus increasing the risk of post-stroke infection. Aging also alters gut microbiota composition inducing dysbiosis. These changes are enhanced by age-related diseases, such as atherosclerosis and type-II diabetes, that further promote vascular aging, predispose to stroke, and exacerbate brain inflammation after stroke. Current advances in aging research suggest that some age-associated alterations may be reversed. Future work will unravel whether such evolving anti-aging research may enable designing strategies to improve stroke outcome in the elderly.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"367-376"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The role of circulating cell-free DNA as an inflammatory mediator after stroke. 卒中后循环无细胞DNA作为炎症介质的作用。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-023-00993-5

Stefan Roth, Saskia R Wernsdorf, Arthur Liesz

{"title":"The role of circulating cell-free DNA as an inflammatory mediator after stroke.","authors":"Stefan Roth, Saskia R Wernsdorf, Arthur Liesz","doi":"10.1007/s00281-023-00993-5","DOIUrl":"https://doi.org/10.1007/s00281-023-00993-5","url":null,"abstract":"Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"411-425"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immune compartments at the brain's borders in health and neurovascular diseases. 健康和神经血管疾病中大脑边界的免疫区。

IF 7.9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 Epub Date: 2023-05-03 DOI: 10.1007/s00281-023-00992-6

Jennifer E Goertz, Lidia Garcia-Bonilla, Costantino Iadecola, Josef Anrather

引用次数: 0

Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke. 急性缺血性和出血性中风的系统性先天性骨髓反应。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 Epub Date: 2022-11-08 DOI: 10.1007/s00281-022-00968-y

Ruth Stephens, John R Grainger, Craig J Smith, Stuart M Allan

{"title":"Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke.","authors":"Ruth Stephens, John R Grainger, Craig J Smith, Stuart M Allan","doi":"10.1007/s00281-022-00968-y","DOIUrl":"10.1007/s00281-022-00968-y","url":null,"abstract":"Acute ischaemic and haemorrhagic stroke account for significant disability and morbidity burdens worldwide. The myeloid arm of the peripheral innate immune system is critical in the immunological response to acute ischaemic and haemorrhagic stroke. Neutrophils, monocytes, and dendritic cells (DC) contribute to the evolution of pathogenic local and systemic inflammation, whilst maintaining a critical role in ongoing immunity protecting against secondary infections. This review aims to summarise the key alterations to myeloid immunity in acute ischaemic stroke, intracerebral haemorrhage (ICH), and subarachnoid haemorrhage (SAH). By integrating clinical and preclinical research, we discover how myeloid immunity is affected across multiple organ systems including the brain, blood, bone marrow, spleen, and lung, and evaluate how these perturbations associate with real-world outcomes including infection. These findings are placed in the context of the rapidly developing field of human immunology, which offers a wealth of opportunity for further research.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"281-294"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system. 神经胶质和细胞外基质在中枢神经系统神经可塑性调控中的作用。

IF 9 2区医学

Seminars in Immunopathology Pub Date : 2023-05-01 DOI: 10.1007/s00281-023-00989-1

Egor Dzyubenko, Dirk M Hermann

{"title":"Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system.","authors":"Egor Dzyubenko, Dirk M Hermann","doi":"10.1007/s00281-023-00989-1","DOIUrl":"https://doi.org/10.1007/s00281-023-00989-1","url":null,"abstract":"Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible regulation of synaptic transmission, neuronal excitability, and network synchronization. Astrocytes regulate synaptogenesis, stabilize synaptic connectivity, and preserve the balance between excitation and inhibition in neuronal networks. Microglia, the brain-resident immune cells, continuously monitor and sculpt synapses, allowing for the remodeling of brain circuits. Glia-mediated neuroplasticity is driven by neuronal activity, controlled by a plethora of feedback signaling mechanisms and crucially involves extracellular matrix remodeling in the central nervous system. This review summarizes the key findings considering neurotransmission regulation and metabolic support by astrocyte-neuronal networks, and synaptic remodeling mediated by microglia. Novel data indicate that astrocytes and microglia are pivotal for controlling brain function, indicating the necessity to rethink neurocentric neuroplasticity views.","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"45 3","pages":"377-387"},"PeriodicalIF":9.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6