Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity

IF 7.9 2区医学 Q1 IMMUNOLOGY

Seminars in Immunopathology Pub Date : 2024-01-03 DOI:10.1007/s00281-023-00999-z

引用次数: 0

Abstract

Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.

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糖蛋白 2 是炎症与免疫之间粘膜平衡的肠道守门员

摘要糖蛋白 2（GP2）是一种广泛分布于消化道的蛋白质，有助于维持粘膜屏障、免疫平衡和抗原特异性免疫反应，同时也与炎症性肠病（IBD）的发病机制有关。本综述揭示了 GP2 在胃肠道内的广泛分布及其与免疫系统之间错综复杂的相互作用。此外，文章还强调了 GP2 自身抗体在诊断和分类 IBD 方面的重要性，以及调节 GP2 以调节免疫和维持粘膜平衡的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Immunopathology 医学-病理学

CiteScore

19.80

自引率

2.20%

发文量

审稿时长

12 months

期刊介绍： The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.