galectins 在宿主免疫中调控自噬和炎性体的作用。

IF 7.9 2区医学 Q1 IMMUNOLOGY

Seminars in Immunopathology Pub Date : 2024-07-23 DOI:10.1007/s00281-024-01018-5

Tzu-Han Lo, I-Chun Weng, Hung-Lin Chen, Fu-Tong Liu

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引用次数: 0

摘要

聚糖结合蛋白家族中的 Galectins 可结合多种聚糖。在细胞质中，这些聚糖可能是内源性（或 "自身"）的，来自受损的内细胞囊泡，也可能是外源性（或 "非自身"）的，存在于入侵的微生物病原体表面。糖蛋白能检测到这些不寻常的糖类细胞膜暴露，并在先天性免疫和适应性免疫中充当协调免疫反应的关键调节因子。本综述概述了加连蛋白如何调节宿主细胞对感染的反应，如自噬、异噬和炎性体依赖性细胞死亡程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The role of galectins in the regulation of autophagy and inflammasome in host immunity.

查看原文本刊更多论文

The role of galectins in the regulation of autophagy and inflammasome in host immunity.

Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or "self"), originating from damaged endocytic vesicles, or exogenous (or "non-self"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.

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来源期刊

Seminars in Immunopathology 医学-病理学

CiteScore

19.80

自引率

2.20%

发文量

审稿时长

12 months

期刊介绍： The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.