Sexually Transmitted Infections最新文献

{"title":"Doxycycline postexposure prophylaxis (doxyPEP) in a patient with antiphospholipid syndrome receiving warfarin: balancing STI prevention and anticoagulation safety.","authors":"George Freer, Nicholas Phillips, Huda Fadzillah, Emma Wallis","doi":"10.1136/sextrans-2026-057143","DOIUrl":"10.1136/sextrans-2026-057143","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of HSV-1 and HSV-2 in the urban population of Qatar: a population-based study.","authors":"Gheyath K Nasrallah, Farah Issa, Parveen B Nizamuddin, Farah Trad, Hamda A Qotba, Nouran Zein, Nadin Younes, Ahmed Ismail, Houssein H Ayoub, Hadi M Yassine, Hiam Chemaitelly, Laith J Abu-Raddad","doi":"10.1136/sextrans-2026-057048","DOIUrl":"https://doi.org/10.1136/sextrans-2026-057048","url":null,"abstract":"<p><strong>Objectives: </strong>Epidemiological data on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections remain limited in the Middle East and North Africa. This study estimated HSV-1 and HSV-2 seroprevalence in the urban population of Qatar and examined associations with demographic characteristics.</p><p><strong>Methods: </strong>A retrospective population-based cross-sectional study was conducted using archived serum specimens from a representative SARS-CoV-2 serosurvey undertaken in 2020 with a probability-based stratified sampling design. HSV-1 and HSV-2 IgG antibodies were measured using Mindray CL-900i chemiluminescence immunoassays. Associations were evaluated using logistic regression.</p><p><strong>Results: </strong>Among 2002 archived specimens with sufficient volume, 2001 were tested for HSV-1 and 1981 for HSV-2. After excluding equivocal results, HSV-1 seroprevalence was 40.4% (789/1955; 95% CI 38.2% to 42.6%) and HSV-2 seroprevalence was 5.0% (99/1974; 95% CI 4.1% to 6.1%). HSV-1 seroprevalence increased from 16.4% (95% CI 12.8% to 20.6%) among those aged 10-19 years to approximately 50% among older age groups. HSV-2 seroprevalence increased steadily from 0.5% (95% CI 0.1% to 1.9%) among those aged 10-19 years to 13.2% (95% CI 7.8% to 20.6%) among those aged ≥60 years. No differences in HSV seroprevalence were observed between sexes. Some nationality differences were observed for HSV-1, with lower seroprevalence among individuals of Indian nationality, while HSV-2 showed small differences across nationalities.</p><p><strong>Conclusions: </strong>HSV-1 and HSV-2 seroprevalence in the urban population of Qatar were lower than regional and global estimates. Distinct age-specific patterns were observed, with early-life acquisition of HSV-1 and a gradual increase in HSV-2 seroprevalence across adulthood.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biett's sign in secondary syphilis: diagnostic value of UV-induced fluorescence dermoscopy.","authors":"Karolina Zarańska, Grażyna Wąsik, Grażyna Kamińska-Winciorek","doi":"10.1136/sextrans-2026-057109","DOIUrl":"https://doi.org/10.1136/sextrans-2026-057109","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in gonorrhoea testing and incidence among gay and bisexual men in Australia during PrEP implementation: an analysis of surveillance data (2012-2023).","authors":"Hein Htet Aung, Anna L Wilkinson, Rebecca Guy, Jason Asselin, Htein Linn Aung, Eric P F Chow, Jason J Ong, Rick Varma, Caroline Thng, Marcus Shaw, Frederick J Lee, David J Templeton, Fabian Yuh Shiong Kong, Nyssa Watson, Vicent J Cornelisse, Dash Heath-Paynter, Margaret E Hellard, Mark A Stoove, Michael W Traeger","doi":"10.1136/sextrans-2026-056909","DOIUrl":"https://doi.org/10.1136/sextrans-2026-056909","url":null,"abstract":"<p><strong>Objectives: </strong>Gonorrhoea incidence is increasing globally, with gay and bisexual men (GBM) over-represented in notifications. Changes in behaviour, sexual networks and screening practices associated with HIV pre-exposure prophylaxis (PrEP) uptake and treatment-as-prevention may influence gonorrhoea transmission. We describe trends in gonorrhoea testing and incidence among GBM over 12 years spanning PrEP implementation in Australia.</p><p><strong>Methods: </strong>We conducted a retrospective study using surveillance data from 67 sexual health and general practice clinics between 1 January 2012 and 31 December 2023. For testing analyses, we included GBM with ≥1 visit and calculated annual test uptake (proportion of attendees tested at least once). For incidence analyses, we included GBM with ≥2 tests and calculated annual gonorrhoea incidence per 100 person-years (py). Test uptake and incidence were stratified by HIV status and PrEP use (ever vs never prescribed PrEP). Poisson regression explored factors associated with incident gonorrhoea, adjusted for calendar year and age.</p><p><strong>Results: </strong>A total of 193 053 GBM attended a clinic during the study period, of which 176 244 (91.3%) had ≥1 test. Annual test uptake increased from 58.7% in 2012 to 75.2% in 2023, largely driven by increased testing among ever-PrEP-users. Among 119 741 GBM in incidence analyses, there were 61 896 gonorrhoea infections over 542 949 py (incidence rate=11.4/100 py). From 2012 to 2023, incidence among HIV-negative ever-PrEP users increased from 6.2 to 19.6/100 py (p<0.001), and among GBM with HIV increased from 8.6 to 18.8/100 py (p<0.001). GBM with recurrent infections (n=13 620; 11.4%) accounted for 69.1% of all diagnoses. Ever being prescribed PrEP (adjusted incidence rate ratio (aIRR)=2.40, 95% CI: 2.35 to 2.45) and living with HIV (aIRR=3.05, 95% CI: 2.97 to 3.13) were associated with incident gonorrhoea.</p><p><strong>Conclusions: </strong>In this large cohort of GBM, gonorrhoea incidence significantly increased during PrEP implementation, although incidence was already rising before large-scale PrEP roll-out in 2016. GBM with HIV, PrEP users or those previously diagnosed with gonorrhoea should be prioritised for testing and prevention strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we predict reproductive complications after <i>Chlamydia trachomatis</i> infection? A cohort study integrating demographic, behavioural, host genetic and infection-related factors.","authors":"Zoïe W Alexiou, Bernice M Hoenderboom, Nicole H T M Dukers-Muijrers, Sander Ouburg, Christian J P A Hoebe, Birgit H B van Benthem, Servaas A Morré","doi":"10.1136/sextrans-2025-056761","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056761","url":null,"abstract":"<p><strong>Objectives: </strong><i>Chlamydia trachomatis</i> (chlamydia) infection has a variable course; most infections resolve but some lead to reproductive complications. Behavioural, immunological and host genetic factors likely influence risk. We aimed to identify predictors of complications in persons with and without chlamydia and develop prediction models for risk stratification.</p><p><strong>Methods: </strong>We analysed data from a long-term cohort of Dutch individuals registered as female in municipal registries and previously screened for chlamydia, including demographic, behavioural, chlamydia-infection and serology variables, and 24 single nucleotide polymorphisms (SNPs). We constructed SNP sets capturing shared biological pathways. Using multivariable Cox regression, we developed and internally validated composite and outcome-specific models for reproductive complications (pelvic inflammatory disease (PID), ectopic pregnancy and tubal factor infertility) stratified by chlamydia status. Model performance was assessed. Point-based risk scores were derived from final models, estimating 15-year risks. Thresholds assessed the proportion classified as high risk and the proportion of outcomes captured.</p><p><strong>Results: </strong>Among the 5704 participants (35 523 and 66 511 person-years in chlamydia-positive and chlamydia-negative groups), 7.1% and 5.4% experienced reproductive complications, respectively. Across outcomes, predictors included behavioural, sociodemographic and immune-related genetic factors, with most identified SNPs known to be involved in immune pathways. Model discrimination was modest (area under the curve ~0.65). Using a ≥15% predicted risk threshold, 54% of chlamydia-positive individuals were classified as high risk of reproductive complications, capturing 75% of composite outcomes (positive predictive value (PPV) 9.7%). For PID, 27% were classified as high risk, capturing 39% of cases (PPV 6.9%), and for ectopic pregnancy, 1.7% were classified as high risk, capturing 10% of cases (PPV 11.8%).</p><p><strong>Conclusions: </strong>Prediction models integrating behavioural, sociodemographic and host genetic factors showed modest performance, with better classification for chlamydia-positive individuals and PID than for ectopic pregnancy. Individual-level risk stratification is unlikely to be clinically useful, supporting population-level or group-level targeting of prevention and care.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, knowledge and acceptability of HIV pre-exposure prophylaxis among women of black descent attending sexual health clinics in England: a cross-sectional survey.","authors":"Patricia Williams, Franklin Odini, Cadie Hibberd, Ayo-Ola Okunwobi-Smith","doi":"10.1136/sextrans-2026-056948","DOIUrl":"https://doi.org/10.1136/sextrans-2026-056948","url":null,"abstract":"<p><strong>Objectives: </strong>Women of black descent in England experience a disproportionate burden of HIV but remain under-represented among users of HIV pre-exposure prophylaxis (PrEP). Evidence on PrEP awareness, knowledge and acceptability in this population is limited. This study assessed these factors among women attending National Health Service (NHS) Sexual Health clinics.</p><p><strong>Methods: </strong>An exploratory cross-sectional survey was conducted at two level 3 NHS Sexual Health services in England between August 2023 and May 2024. Women aged ≥16 years who self-identified as being of black ethnicity or descent were recruited using consecutive convenience sampling. Participants received a standardised educational leaflet on HIV and PrEP, as a brief educational intervention, before completing a structured questionnaire assessing demographics, PrEP awareness and knowledge prior to education, HIV testing awareness, sexual health behaviours, perceived HIV risk and willingness to consider PrEP following education. Data were analysed descriptively.</p><p><strong>Results: </strong>Sixty-four women participated. Before receiving PrEP information, 73.0% had not previously heard of PrEP, 71.4% did not know its purpose and 80.0% were unaware of how it is taken. Following educational exposure, 72.3% reported that they would consider using PrEP ('yes' or 'maybe').Inconsistent or no condom use was reported by 78.0% of participants, and 17.3% expressed concerns about partner concurrency. One-fifth (20.0%) were unaware of where HIV testing services could be accessed. Concerns about medication side effects, daily pill-taking and potential drug interactions were the most reported barriers to PrEP use.</p><p><strong>Conclusions: </strong>Women of black descent attending NHS Sexual Health clinics demonstrated low awareness and knowledge of PrEP, representing a significant barrier to engagement. However, PrEP acceptability was generally favourable following brief educational exposure. Further community-based research is needed to explore wider determinants of PrEP uptake and support equitable HIV prevention strategies.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of reduced chlamydia testing on STI testing and provider preferences in the Netherlands: an experimental vignette study.","authors":"Ilja Josephina Willemina van Bergen, Janneke Cornelia Maria Heijne, Marijn de Bruin, Daphne Amanda van Wees","doi":"10.1136/sextrans-2025-056703","DOIUrl":"10.1136/sextrans-2025-056703","url":null,"abstract":"<p><strong>Objectives: </strong>The restrictive chlamydia testing guidelines for asymptomatic individuals at Dutch sexual health centres (SHCs) since January 2025 may influence perceptions and attitudes towards testing for sexually transmitted infections (STIs). This study aimed to assess the potential impact of this guideline change on STI testing preferences among young people and to examine determinants and underlying motivations of these preferences.</p><p><strong>Methods: </strong>Heterosexuals aged 16-34 in the Netherlands, recruited via social media and SHCs, completed an online survey (April-June 2024). STI testing preferences (SHCs, general practitioners (GPs), commercial self-sampling tests or not testing) before and after the anticipated guideline change were assessed in a hypothetical scenario involving condomless sex with a new partner without having STI-related symptoms after. Participants initially preferring SHCs were grouped according to post-change preferences. We used logistic regression to identify factors associated with preferences and thematic analysis to explore motivations.</p><p><strong>Results: </strong>Of 1179 participants, 68% (95% CI 65% to 71%) initially preferred SHCs as a testing provider. After the guideline change, among this group, 24.2% (95% CI 21% to 27%) still preferred SHCs, 51.5% (95% CI 48% to 55%) switched to a preference for testing at GPs, 18% (95% CI 16% to 21%) to self-sampling and 6.2% (95% CI 5% to 8%) opted out. Switching to GPs was associated with younger age and high self-efficacy and control beliefs; choosing self-sampling with older age (>24) and university education; and opting out with inconsistent condom use and low health goals compared with preferring SHCs. Motivations included test costs, symptom absence and perceived chlamydia prevalence.</p><p><strong>Conclusion: </strong>Changing chlamydia testing guidelines at SHCs may cause a shift in testing preferences to GPs or self-sampling and may discourage some from testing. These findings underscore the need for targeted communication and ongoing monitoring of STI testing behaviour to maintain STI testing uptake and are relevant for countries facing similar changes to chlamydia testing guidelines.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"356-363"},"PeriodicalIF":3.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral and anal shedding of <i>Treponema pallidum</i> in patients with syphilis in the DOXYVAC cohort.","authors":"Romain Salle, Philippe Alain Grange, Moussa Ouattara, Lambert Assoumou, Valentin Leducq, Nadjet Benhaddou, Jade Ghosn, Jean-Michel Molina, Nicolas Dupin","doi":"10.1136/sextrans-2025-056712","DOIUrl":"10.1136/sextrans-2025-056712","url":null,"abstract":"<p><strong>Objectives: </strong>The incidence of syphilis, caused by <i>Treponema pallidum</i> (TP), has increased significantly in recent years in Western countries, particularly among men who have sex with men (MSM). Recent data suggest that ongoing transmission may be facilitated by undetected mucosal excretion of TP. This study focuses on patients who had incident syphilis during the DOXYVAC study in order to evaluate oral and anal excretion of TP by molecular biology before, during and after infection.</p><p><strong>Methods: </strong>During the DOXYVAC study, incident syphilis was defined as new TP haemagglutinations assay positivity or increased Venereal Disease Research Laboratory (VDRL) titres. Quantitative PCR tests were performed on stored oral and anal samples from the visit preceding the diagnosis, the diagnostic visit of syphilitic infection and the follow-up visit. For each TP-positive PCR sample, detection of 23S ribosomal RNA (rRNA) (azithromycin resistance) and 16S rRNA (doxycycline resistance) mutations was performed.</p><p><strong>Results: </strong>Among the 556 participants, 44 cases of incident syphilis occurred in 43 patients. 11 patients (25%) had at least one PCR-positive site, including nine patients in the non-postexposure prophylaxis (PEP) group and two in the doxycycline PEP group. Eight patients had positive TP PCRs at diagnosis, two before diagnosis and one after. A total of eight anal samples and six oral samples tested positive. PCR-positive patients were more likely to be VDRL-positive with higher titres, suggesting more active infection. No mutations associated with doxycycline resistance were detected, while 75% patients had azithromycin-resistant TP strains.</p><p><strong>Conclusions: </strong>This study shows that a significant proportion of patients have oral or anal TP excretion, sometimes several months before serological diagnosis, suggesting potential early asymptomatic transmission. The integration of the TP PCR assay into routine screening of high-risk MSM could enable earlier detection and treatment of these patients. The absence of doxycycline resistance is reassuring, but continued monitoring remains essential.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"391-393"},"PeriodicalIF":3.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High burden of asymptomatic sexually transmitted infections among recently arrived African migrants in Spain: a prospective screening study.","authors":"Josue Pendones-Ulerio, María Jesús Castaño-Aroca, María Fernanda Ramirez-Hidalgo, Moncef Belhassen-García","doi":"10.1136/sextrans-2026-057029","DOIUrl":"10.1136/sextrans-2026-057029","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"409-410"},"PeriodicalIF":3.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-acting antiretrovirals-in it for the long haul.","authors":"Matthew Page, Fiona Cresswell","doi":"10.1136/sextrans-2026-056916","DOIUrl":"https://doi.org/10.1136/sextrans-2026-056916","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"102 6","pages":"413-414"},"PeriodicalIF":3.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}