Sexually Transmitted Infections最新文献

{"title":"Public health and clinical response to an mpox outbreak in Slovenia: case study, 2022-2023.","authors":"Danilo Češljarac, Kristina Brečko, Martin Štrumbelj, Sabrina Likar, Barbara Kokošar Ulčar, Mateja Zalaznik, Nataša Kejžar, Katarina Resman Rus, Miša Korva, Tatjana Avšič Županc, Eva Grilc, Andreja Murnik Rauh, Maja Mastnak, Anja Becner, Maruška Marovt, Mitja Lenart, Mojca Matičič","doi":"10.1136/sextrans-2024-056318","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056318","url":null,"abstract":"<p><strong>Objectives: </strong>The emergence of mpox outbreaks in non-endemic areas, characterised by human-to-human transmission and unique clinical presentations, poses challenges in containment efforts. This study aimed to analyse the 2022 outbreak in Slovenia and characterise the country's response to the outbreak.</p><p><strong>Methods: </strong>A retrospective, observational study analysed all confirmed mpox cases in Slovenia between 1 January 2022 and 31 December 2023 and specific public health measures and responses in the country to contain the mpox outbreak. Data were collected from clinical facilities, public health institutions and civil society organisations and analysed accordingly.</p><p><strong>Results: </strong>Of 149 suspected cases tested, 49 were confirmed, all cisgender men, predominantly men who have sex with men (93%), exhibiting skin lesions, with 20% being HIV infected and 62% reporting recently having sex abroad. Hospitalisation was required in 14%, no specific treatment was needed, and no fatalities occurred. After the rapid spread of mpox from May to mid-July 2022, only occasional cases were detected afterwards until the outbreak's termination in early September. Slovenia's containment strategy started immediately after the first case detection, involving rapid diagnostics and active case search, centralised case management and targeted public health measures. The LGBTIQ+ (Lesbian, Gay, Bisexual, Trans, Intersex, Queer and other sexual identities) community civil society organisation Legebitra played a critical role by launching awareness campaigns and promoting easily accessible vaccination. Despite its late start in September 2022, by the end of 2023, the vaccination campaign achieved coverage of 309 individuals.</p><p><strong>Conclusions: </strong>Slovenia's response to the 2022 mpox outbreak highlights prompt multisectoral collaboration, community engagement and timely public health interventions. Rapid diagnostics, centralised case management and targeted outreach likely contributed to containment. While vaccination had limited impact during the outbreak, its importance for long-term prevention cannot be overstated. As the global threat of mpox persists, continuous surveillance, cross-border cooperation and proactive vaccination strategies are recommended activities to address future challenges.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based self-collection of biological samples, including vaginal swabs: a mixed methods study for Britain's fourth National Survey of Sexual Attitudes and Lifestyles (Natsal-4).","authors":"Clarissa Oeser, Pam Sonnenberg, Magnus Unemo, Katharine Sadler, Soazig Clifton, Jo Gibbs, Simon Beddows, Rebecca Hamilton, Abraham Roodt, Stephanie Migchelsen, Emily Dema, Alexandra David, Catherine H Mercer, Nigel Field","doi":"10.1136/sextrans-2024-056386","DOIUrl":"10.1136/sextrans-2024-056386","url":null,"abstract":"<p><strong>Objectives: </strong>The decennial National Surveys of Sexual Attitudes and Lifestyles (Natsal) provide general population prevalence estimates in Britain for key sexually transmitted infections (STIs) through biosampling. Since methodological choices can impact acceptability and response rates, we evaluated processes for Natsal-4, including face-to-face and remote interview arrangements, non-return of test results and vaginal swab collection in two pilot studies.</p><p><strong>Methods: </strong>The pilots were conducted during June to August 2021 and February to March 2022. Participants aged 16-59 years were invited to provide urine samples (cisgender men and trans/gender diverse) or three vaginal swabs (cisgender women; urine was requested if vaginal swabs were declined) following interview. Samples were self-collected at home and posted to the laboratory by the interviewer if the interview was face to face, or by the participant if they preferred to collect the sample later or the interview was remote. Process feedback was collected after the first pilot via qualitative interviews with participants and after both pilots through informal interviewer debriefing.</p><p><strong>Results: </strong>Of 261 participants interviewed (pilot 1=130; pilot 2=131), 161 (62%) consented to biosampling, of which 129 (49%) provided samples. A sample was received from 78/153 (51%) of women, of whom 60 (77%) provided vaginal swabs and 18 (23%) provided a urine sample. A urine sample was received from 51/108 (47%) cisgender men or trans/gender diverse participants. All samples collected immediately after face-to-face interviews were received (n=77), while 64% of samples from participants consenting to post samples after face-to-face interviews and 60% after remote interviews were received. Process feedback confirmed our methods were broadly acceptable.</p><p><strong>Conclusions: </strong>We demonstrated that our approach to biosampling and STI testing for a national sexual health survey was reasonably acceptable and feasible in the period coming out the COVID-19 pandemic. Self-collection of vaginal swabs for research, which provide higher testing sensitivity than urine, was feasible and acceptable in a home setting.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>One way or another, you are not going to fit</i>: trans and gender diverse people's perspectives on sexual health services in the United Kingdom.","authors":"Tom Witney, Greta Rait, John Saunders, Lorna Hobbs, Laura Mitchell, Jay Stewart, Lorraine K McDonagh","doi":"10.1136/sextrans-2024-056231","DOIUrl":"10.1136/sextrans-2024-056231","url":null,"abstract":"<p><strong>Objectives: </strong>Trans and/or gender diverse (T/GD) people in the UK are less likely to access sexual health services (SHS) than cisgender people and are more likely to report negative experiences. The British Association for Sexual Health and HIV (BASHH) developed expert recommendations for T/GD-inclusive SHS, but these lack service user perspectives. This study addressed this gap by asking T/GD people how SHS could be T/GD-inclusive.</p><p><strong>Methods: </strong>Semistructured interviews (n=33) and focus groups (n=26) were conducted with T/GD people aged 17-71 years old recruited through community organisations and social media, exploring experiences of SHS and inclusivity. Study design, materials and analysis were informed by T/GD people and an advisory committee of charities and sexual health clinicians. Data were analysed using thematic analysis, managed using NVivo.</p><p><strong>Results: </strong>Participants often expected that SHS were not set up for T/GD people. This was reinforced by poor experiences in other healthcare settings and the lack of information on NHS websites. Some participants had been denied care because they were 'too complex'. Participants wanted to know that SHS had engaged with the needs of T/GD people and looked for hallmarks of inclusivity, such as Trans Pride flags in reception areas. Some participants wanted specialist T/GD services, but others preferred to access general SHS. Staff attitudes were a key factor underpinning inclusivity. Anticipating having their identity questioned or needs dismissed, participants sought kindness and openness. Although the needs of T/GD people are diverse and different from cisgender service users, participants stressed that SHS staff already had the skills to deliver sensitive person-centred care and emphasised the value of inclusive SHS.</p><p><strong>Conclusion: </strong>These findings provide insight into what a sample of T/GD people in the UK consider important for T/GD-inclusive SHS. Participants' suggestions align with and reinforce BASHH expert recommendations. Importantly, they highlight the need for ongoing engagement to deliver T/GD-inclusive SHS.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of renal outcomes and management of PrEP users with estimated glomerular filtration rates less than 60 mL/min/1.73 m².","authors":"Victoria Tittle, Nicolo Girometti, Jonathan Joseph Goodfellow, Stephen Cole, Sheel Patel, Marta Boffito, Sheena McCormack, Rachael Jones","doi":"10.1136/sextrans-2024-056411","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056411","url":null,"abstract":"<p><p>This retrospective service evaluation reviews practical measures for pre-exposure prophylaxis (PrEP) users with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² Of 35 724 PrEP users, 361 had an eGFR <60 mL/min/1.73 m², of whom 16% required non-tenofovir disoproxil/emtricitabine PrEP formulations. Majority of cases required simple and conservative management, with repeat sampling and/or stopping of the supplements and/or recreational drugs.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-related microaggressions and depressive symptoms among people living with HIV: the mediating roles of internalised stigma and coping with shame.","authors":"Aliye Canan Taşlıoğlu Sayıner, Bulent Turan, Arzu Nazlı, Deniz Özer, Hamed Abdollahpour Ranjbar, Salih Atakan Nemli, Ahmad Nejat Ghaffari, Merve Mert Vahabi, Nur Miray Ayhan, Deniz Gokengin, Andrea Norcini Pala","doi":"10.1136/sextrans-2024-056354","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056354","url":null,"abstract":"<p><strong>Objectives: </strong>Overtly experienced HIV-related stigma is associated with depressive symptoms for people living with HIV (PLWH). Research suggests that an important mediating mechanism in this association is internalised stigma, where PLWH accept negative societal views about HIV, apply them to themselves and develop a negative view of themselves. Microaggressions are subtle and indirect discriminatory behaviours and, like overtly experienced stigma, may also contribute to depressive symptoms. We tested this hypothesis and examined the mediating roles of internalised stigma and maladaptive ways of coping with shame in the association between microaggressions and depressive symptoms among PLWH in Türkiye.</p><p><strong>Methods: </strong>This study examines the serial mediating roles of internalised HIV stigma and shame-related coping strategies (ie, withdrawal and self-attack) in the association between HIV-related microaggressions and depressive symptoms among PLWH. PLWH in Izmir, Türkiye (N=308) completed validated scales measuring experiences of microaggressions, internalised HIV stigma, coping strategies related to shame and depression symptoms.</p><p><strong>Results: </strong>Structural equation modelling results suggest that internalised HIV stigma significantly mediates the relationship between HIV-related microaggressions and depression symptoms. Furthermore, serial mediation analysis suggests that withdrawal and self-attack strategies of coping with shame mediate the association between internalised HIV stigma and depressive symptoms. Thus, internalised HIV stigma and shame-related coping strategies may partially stem from experiencing HIV-related microaggressions and may negatively affect the mental health of PLWH.</p><p><strong>Conclusions: </strong>Findings highlight the importance of assessing subtle forms of discrimination (ie, microaggressions) given their negative impact on the self-concept of PLWH. In addition to addressing negative attitudes and behaviours against PLWH in society, interventions that help PLWH cope with shame-related experiences might improve their mental health.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and symptoms associated with <i>Mycoplasma genitalium</i> infections among heterosexual men in Hanoi, Vietnam.","authors":"Hoai Bac Nguyen, Huynh Dang Khoa Nguyen, Minh Quan Pham, Cao Thang Nguyen, Paul C Adamson","doi":"10.1136/sextrans-2024-056396","DOIUrl":"10.1136/sextrans-2024-056396","url":null,"abstract":"<p><strong>Background: </strong><i>Mycoplasma genitalium</i> (MG) is a critical pathogen of sexually transmitted infections (STIs) in men, associated with high antibiotic resistance. Understanding the clinical characteristics of MG infections can improve testing and treatment guidelines.</p><p><strong>Aims: </strong>To investigate the clinical features and characteristics of asymptomatic, acute and chronic MG infections in heterosexual males.</p><p><strong>Methods: </strong>From January 2018 to September 2023, men diagnosed with urethral STIs using multiplex real-time PCR were enrolled into this cross-sectional study. Testing indications included males with urethritis, suspected STIs and asymptomatic screening. Based on clinical symptoms, participants were classified as acute, chronic or asymptomatic groups. An electronic-based survey was administered to assess demographic, behavioural and clinical information. Univariate and multivariate logistic regression were performed to assess for factors associated with the presence of symptoms.</p><p><strong>Result: </strong>Among the 2102 men who have sex with women and were tested for STI, 879 records met the eligibility criteria for further analysis; MG was detected in 14.6% of the 2102 cases. Most patients presented with acute urethral symptoms (75.6%). Among men infected with MG, mono-infection accounted for 52.8%, while <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> co-infections occurred in 39.3% and 21.3%, respectively. Co-infections were more prevalent among acute urethritis compared with chronic urethritis or asymptomatic groups. Multivariable analysis revealed associations between chronic symptoms with absence of urethral discharge (aOR 0.31; 95% CI 0.2 to 0.47), previous antibiotic use (aOR 6.83; 95% CI 4.47 to 10.4), marriage (aOR 1.66; 95% CI 1.09 to 2.51) and history of STIs (aOR 2.08; 95% CI 1.24 to 3.49).</p><p><strong>Conclusion: </strong>Our study revealed a 14.6% prevalence of MG among individuals tested for STIs. Most patients presented with acute urethral symptoms, while chronic symptoms were associated with marriage, antibiotic use history and previous STIs. Routine MG screening of asymptomatic patients is not recommended, but improved access to diagnostics and further research is needed for clinical practice in low-resource settings.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphogranuloma venereum (LGV) <i>ompA</i>-subvariants of the Portuguese collection of <i>Chlamydia trachomatis</i>, 2007-2023.","authors":"Zohra Lodhia, Dora Cordeiro, Cristina Correia, Inês João, Teresa Carreira, Alexandra Nunes, Rita Ferreira, Sandra Schäfer, Elzara Aliyeva, Clara Portugal, Isabel Monge, Elsa Gonçalves, Susana Matos, Ana Paula Dias, Rita Corte-Real, Luís Vieira, Joao Paulo Gomes, Vítor Borges, Maria Jose Borrego","doi":"10.1136/sextrans-2024-056427","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056427","url":null,"abstract":"<p><strong>Background: </strong>Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by <i>Chlamydia trachomatis ompA</i>-genotypes L1-L3, with increasing numbers of detected cases across Europe. Here, we analysed diversity and temporal distribution of the LGV <i>ompA</i>-subvariants detected in Portugal between 2007 and 2023, in order to better understand the dissemination and diversification landscape of LGV strains.</p><p><strong>Methods: </strong>The collection of the Portuguese National Reference Laboratory includes 1188 LGV <i>ompA</i>-genotyped samples between 2007 and 2023. In-depth analysis of the diversity of LGV <i>ompA</i>-subvariants circulating in Portugal across the years was performed, identifying newly described subvariants and integrating this data in a comprehensive compilation with all representative LGV <i>ompA</i>-subvariants described globally.</p><p><strong>Results: </strong>L2 <i>ompA</i>-variant (L2/434/Bu) was consistently the most frequently detected in our collection, with annual proportions ranging from 34.0% to 82.9%, between 2016 and 2023. L2bV5 was the second most frequent followed by L2b, ranging from 5.0% to 27.9% and 2.6% to 23.7% across the years, respectively, from 2017 to 2023. We highlighted the emergence and considerable increase in circulation of L1-like <i>ompA</i>-subvariants in recent years, representing 13.7% of LGV sequences in 2023. We also identified 13 novel LGV <i>ompA</i>-subvariants that had not been described before, differing by up to three mutations from the respective genotype reference sequences.</p><p><strong>Conclusions: </strong>This study contributes to the worldwide picture of the LGV molecular epidemiology, highlighting the importance of long-term molecular surveillance to monitor the circulation and geographical spread of LGV and to timely identify and track new strains, such as the recently emerging L1-like <i>ompA</i>-subvariants.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline prophylaxis for bacterial sexually transmitted infection prevention in Vietnam: awareness, attitudes and willingness to use among men who have sex with men using HIV-PrEP.","authors":"Hao T M Bui, Paul C Adamson, Jeffrey D Klausner, Giang M Le, Pamina M Gorbach","doi":"10.1136/sextrans-2024-056449","DOIUrl":"10.1136/sextrans-2024-056449","url":null,"abstract":"<p><strong>Objectives: </strong>Doxycycline prophylaxis shows promise for bacterial sexually transmitted infection (STI) prevention, but data primarily come from high-income countries. This study assessed awareness, willingness and factors associated with willingness to use doxycycline for bacterial STI prevention among men who have sex with men (MSM) using HIV pre-exposure prophylaxis (HIV-PrEP) in Vietnam.</p><p><strong>Methods: </strong>Between 25 January and 4 February 2024, a cross-sectional study recruited males aged ≥18 years who reported having sex with men in the past 12 months from 11 HIV-PrEP clinics in Hanoi and Ho Chi Minh City. Self-administered surveys were conducted, and multivariable logistic regression was applied to identify factors associated with willingness to use doxycycline prophylaxis.</p><p><strong>Results: </strong>Among 350 participants, the median age was 25 (IQR 21-30), and 10.6% self-reported a bacterial STI diagnosis in the past 12 months. In the previous 6 months, the median number of sex partners was 2 (IQR 1-4), 53.1% reported condomless anal sex. Awareness of doxycycline was low (20.2%; 65/322); however, 75.4% (264/350) expressed willingness to use it, with 63.6% (168/264) preferring doxyPrEP. Participants who disclosed HIV-PrEP use to all sex partners (adjusted OR (aOR) 4.17; 95% CI 1.84, 9.46) and those with higher perceived STI risk (aOR 1.12; 95% CI 1.03, 1.22) were more likely to report willingness to use doxycycline prophylaxis. Concerns about daily medication (aOR 0.43; 95% CI 0.24, 0.81) and fear of judgement from peers (aOR 0.41; 95% CI 0.21, 0.81) were associated with lower willingness.</p><p><strong>Conclusions: </strong>Knowledge of doxycycline prophylaxis among MSM on HIV-PrEP in Vietnam was low. However, most expressed willingness to use it, with two-thirds preferring doxyPrEP. Findings highlight the need to disseminate information on doxycycline prophylaxis for bacterial STI prevention, monitoring the usage and evaluating comparative effectiveness of doxyPEP and doxyPrEP to guide implementation efforts in Vietnam.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in syphilis and syphilitic uveitis among South Korean adults in 2010-2019: a nationwide cohort study.","authors":"EunAh Kim, Soorack Ryu, Su Jeong Song","doi":"10.1136/sextrans-2024-056417","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056417","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate the epidemiology, clinical manifestations, and diagnostic and management patterns of ocular syphilis in South Korea.</p><p><strong>Methods: </strong>This retrospective nationwide cohort study analysed health claim data from 2010 to 2019 for individuals aged ≥20 years diagnosed with syphilis, with follow-up through 2021. Age- and sex-adjusted incidence and prevalence rates were calculated for ocular conditions including anterior uveitis, posterior uveitis, panuveitis and optic neuritis. Diagnostic and management trends were evaluated, and multivariate Cox regression analyses assessed the impact of demographic factors and comorbidities.</p><p><strong>Results: </strong>From 2010 to 2019, the incidence rate of syphilis increased from 99.1 to 136.1 per 100 000. Among the 448 085 syphilis cases, 5118 developed anterior uveitis, 777 posterior uveitis, 551 panuveitis and 80 optic neuritis. While all types of uveitis showed increasing trends, anterior uveitis exhibited the steepest rise from 0.18 per 100 000 in 2010 to 1.40 per 100 000 in 2021. Diagnostic practices for ocular syphilis included 80.4% for dilated fundus examination, 73.7% for fundus photography and 11.0% for fluorescein angiography. Laser photocoagulation and vitrectomy were performed in 5.7% and 4.5% of patients with uveitis, respectively. Multivariate analyses showed that each additional year of age increased the risk for anterior and posterior uveitis by 4% and optic neuritis by 2%. Hypertension, diabetes mellitus and dyslipidaemia increased the risk of one or more ocular syphilis manifestations.</p><p><strong>Conclusion: </strong>In 2010-2019, the incidence of syphilis in South Korea significantly increased, with rates higher than previous studies. Age, sex and metabolic comorbidities were associated with an increased risk of ocular syphilis. These results indicate the need for vigilance in screening for ocular syphilis, and the importance of comprehensive eye examinations in patients with syphilis.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between HIV risk perception, knowledge of biomedical prevention and sexual behaviour among sub-Saharan African immigrants living in a precarious situation in France.","authors":"Karna Coulibaly, Anne Gosselin, Nicolas Derche, Romain Mbiribindi, Annabel Desgrées du Loû","doi":"10.1136/sextrans-2024-056392","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056392","url":null,"abstract":"<p><strong>Objectives: </strong>Sub-Saharan African immigrants are particularly affected by HIV in France, with many acquiring the infection after migration due to precarious circumstances that increase their vulnerability. This study aimed to explore the association between HIV risk perception, knowledge of biomedical HIV prevention methods and sexual behaviours among sub-Saharan African immigrants living in precarious conditions in the greater Paris area.</p><p><strong>Methods: </strong>This cross-sectional study analysed data from 614 participants in the MAKASI project, conducted in the greater Paris area (2019-2020). Sociodemographic characteristics, living conditions, knowledge of biomedical HIV prevention methods (postexposure prophylaxis, treatment as prevention and pre-exposure prophylaxis (PrEP)) and sexual behaviours were described by sex using Pearson's χ² tests. HIV risk perception, defined as self-reported exposure to HIV comparable to or greater than the general population, was analysed by participant characteristics. A multivariable logistic regression model identified factors associated with HIV risk perception using variables with a significance threshold of 20%.</p><p><strong>Results: </strong>Most participants (76.5%) were men, with a median age of 34 years (IQR: 29-41) and living in precarious conditions. Forty-one per cent of respondents reported perceiving their HIV exposure risk as comparable to or greater than the general population. Participants aware of PrEP (adjusted OR (aOR) =2.60 (1.17-5.80); p<0.020) and those who had sex with occasional partners without a condom within in the 3 months preceding the survey (aOR=1.89 (1.12-3.18); p<0.017) were more likely to report the same or greater risk of HIV exposure.</p><p><strong>Conclusions: </strong>Our findings reveal that PrEP knowledge and sex with occasional partners, particularly participants who did not use condoms, are associated with increased HIV risk perception among sub-Saharan African immigrants. Further research should explore the relationship between PrEP uptake and HIV risk perception in this population.</p><p><strong>Trial registration number: </strong>NCT04468724.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}