Sexually Transmitted Infections最新文献

{"title":"Pilot study to explore the characteristics of Chagossian people living with HIV in Crawley, UK.","authors":"Fionnuala Finnerty, Marie Tessa Simmy Ramrajsingh, Eva Bangova, Lena Abdu, Sibusisiwe Mutambara, Emily Hunter, Daniel Richardson","doi":"10.1136/sextrans-2025-056583","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056583","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community engagement for HPV vaccination in Nigeria.","authors":"Assanatou Bamogo, Agatha E Wapmuk, Semilore P Osunsanmi, Eneyi Kpokiri, Titilola A Gbaja-Biamila, Juliet Iwelunmor, Oliver Ezechi, Jennifer S Smith, Joseph D Tucker","doi":"10.1136/sextrans-2025-056496","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056496","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Chlamydia trachomatis</i> genovariant L2b in men who have sex with men in Taiwan, 2020-2023.","authors":"Chin-Shiang Tsai, Bo-Yang Tsai, Sung-Hsi Huang, Miao-Hui Huang, Guan-Jou Chen, Chi-Ying Lin, Chien-Ching Hung, Wen-Chien Ko","doi":"10.1136/sextrans-2024-056477","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056477","url":null,"abstract":"<p><strong>Objectives: </strong>Lymphogranuloma venereum (LGV) caused by <i>Chlamydia trachomatis</i> genotypes L1-L3 has been resurging among men who have sex with men (MSM) and people with HIV (PWH) in Western countries. While historically attributed to tropical regions, rectal LGV has been rarely recognised in Asia, with Taiwan recently becoming the second Asian country to report cases.</p><p><strong>Methods: </strong>A multicentre, laboratory-based surveillance was conducted from January 2020 to December 2023 in Taiwan. Specimens were collected from MSM through syndromic testing and screening of high-risk populations. <i>C. trachomatis</i> was identified using commercial multiplex PCR assays, with genotyping performed through <i>ompA</i> gene sequencing. LGV-positive samples underwent multilocus sequence typing (MLST) following established protocols.</p><p><strong>Results: </strong>Among 446 <i>C</i>. <i>trachomatis</i>-positive samples, 391 (87.7%) underwent successful <i>ompA</i> sequencing. Genovariant L2b accounted for 9.7% of cases, predominantly among PWH with rectal chlamydia (18.2%). PWH accounted for 85.7% of all genovariant L2b cases. Of 38 genovariant L2b samples from 35 cases, 34 (84.2%) samples completed MLST, revealing sequence type (ST) 53 as the predominant strain (74%). ST39 and ST63 were identified as unreported STs in Western countries, along with previously reported ST58. The four identified STs formed a cluster.</p><p><strong>Conclusions: </strong>Our findings indicate the clonal spread of <i>C. trachomatis</i> L2b-ST53 among MSM in Taiwan, primarily affecting PWH. The predominance of ST53 suggests potential international and domestic spread, indicative of the need for enhanced surveillance.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of public health information and prevention measures by gay men, bisexual men and men who have sex with men during the French Mpox outbreak in 2022: the ANRS-MPX-SHS cross-sectional survey.","authors":"Luis Sagaon-Teyssier, Maxime Hoyer, Marie Dos Santos, Marion Mora, Michel Bourrelly, Christel Protière, Gwenaëlle Maradan, Pierre Verger, David Michels, Manuela Salcedo, Annie Velter, Mathilde Certoux, Patrick Peretti-Watel, Phuoc-Bao-Viet Tong, Vivien Lugaz, Vincent Leclercq, Lambert Assoumou, Martin Siguier, Gilles Pialoux, Jean-Michel Molina, Perrine Roux, Bruno Spire, Gabriel Girard","doi":"10.1136/sextrans-2024-056406","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056406","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the acceptability by gay men, bisexual men and other men who have sex with men (GBMSM) of French public health information and prevention measures implemented during the 2022 Mpox outbreak.</p><p><strong>Methods: </strong>ANRS-MPX-SHS \"Mpox: perception of risks, health measures and vaccination\" is a cross-sectional survey conducted in GBMSM between July and September 2022. Online questionnaires collected information about Mpox-related awareness, perceptions and prevention behaviours. Multiple correspondence analysis identified participant profiles according to their level of acceptability of the information and prevention measures implemented during the 2022 outbreak. The study outcome was a variable grouping participants into three profiles: 'strong endorsers', 'uninformed hesitant endorsers' and 'indifferent objectors'. Multinomial logistic regression was used to estimate factors associated with each profile.</p><p><strong>Results: </strong>Of the 5688 participants, 5320 (93.5%) had available data for the outcome. The latter were mostly cisgender men (98%), aged between 35 and 54 years (54.5%), with tertiary education (82%); 44% were living in the Greater Paris region. Strong endorsers, uninformed hesitant endorsers and indifferent objectors accounted for 77.8%, 14.4% and 7.8% of the sample, respectively. Participants with tertiary education, those who had sex exclusively with men, those taking pre-exposure prophylaxis (ie, HIV-negative participants), HIV-positive participants and individuals living in the Greater Paris region, were all less likely to be uninformed hesitant endorsers or indifferent objectors. Participants with no lifetime HIV/sexually transmitted infection (STI) screening and those with infrequent screening were, respectively, more likely to belong to these two profiles.</p><p><strong>Conclusions: </strong>Participants' acceptability of the information and prevention measures implemented during the 2022 Mpox outbreak in France depended on the perceived capability of public health authorities to effectively diversify information targets, representations and communication channels. In order to prevent the transmission of Mpox (and other STIs) in the general population in future outbreaks, information and measures adopted must take into account the needs, perceptions and experiences of persons never or not regularly screened for HIV/STIs.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox vaccination uptake in a UK community sample of gay, bisexual and other men who have sex with men (GBMSM) the year following the 2022 clade IIb mpox outbreak.","authors":"Dolores Mullen, Jessica Edney, Dawn Phillips, Ruth Wilkie, David Reid, Catherine M Lowndes, Erna Buitendam, Katy Sinka, Sema Mandal, Catherine H Mercer, John Saunders, Hamish Mohammed, Dana Ogaz","doi":"10.1136/sextrans-2024-056358","DOIUrl":"10.1136/sextrans-2024-056358","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"203-204"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative exploration of the barriers and facilitators to community pharmacy PrEP delivery for UK pharmacists and underserved community members using the COM-B model of behaviour change.","authors":"China Harrison, Hannah Family, Joanna Kesten, Sarah Denford, Jennifer Scott, Caroline Sabin, Joanna Copping, Lindsey Harryman, Sarah Cochrane, John Saunders, Ross Hamilton-Shaw, Jeremy Horwood","doi":"10.1136/sextrans-2024-056308","DOIUrl":"10.1136/sextrans-2024-056308","url":null,"abstract":"<p><strong>Objectives: </strong>Expanding delivery of oral pre-exposure prophylaxis (PrEP) to community pharmacies could improve access, aligning well with the UK government's goals to eliminate new HIV acquisitions by 2030. Using the Capability, Opportunity, Motivation, Behaviour (COM-B) model for behaviour change, the aim of this research was to explore the barriers and facilitators of community pharmacy PrEP delivery, for pharmacists and community members.</p><p><strong>Methods: </strong>Community members at elevated risk of acquiring HIV and community pharmacists were recruited to participate in semi-structured interviews. Interviews were recorded, transcribed, and thematically analysed within the framework of the COM-B model.</p><p><strong>Results: </strong>17 interviews with pharmacists (pharmacy owners n=7; employed pharmacists n=6; locums n=4) and 24 with community members (black African women n=6; other women n=2; young adults aged 18-25 years n=6; transgender people n=6; female sex workers n=4) were carried out. Capability barriers included suboptimal awareness and knowledge of PrEP, pharmacy facilities and pharmacist roles in delivering public health services. Opportunity barriers included a lack of staff capacity, privacy and pharmacy screening and monitoring facilities. Motivational barriers included a concern that increased access could increase sexually transmitted infections and involve a financial cost. Capability facilitators included awareness raising, HIV and PrEP training and education. Opportunity facilitators included PrEP appointments and the accessibility of pharmacies. Motivational facilitators included a preference for pharmacy delivery over other models (eg, sexual health, General Practitioner (GP)), and a belief that it would be discrete and less stigmatising.</p><p><strong>Conclusion: </strong>Pharmacy PrEP delivery is acceptable but for it to be feasible, results point to the need for the development of a behaviour change intervention focusing on education, training and awareness raising, targeting pharmacists and community members to stimulate patient activation and de-stigmatise HIV. This intervention would need to be facilitated by system and environmental changes (eg, commissioning service).</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"160-167"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in HIV risk factors between South African adolescents and adult women and their association with sexually transmitted infections.","authors":"Pamela Mkhize, Celia Mehou-Loko, Nokuthula Maphumulo, Nina Radzey, Andrea G Abrahams, Sengeziwe Sibeko, Rushil Harryparsad, Monalisa Manhanzva, Bahiah Meyer, Phumla Radebe, Lenine J P Liebenberg, Sinaye Ngcapu, Nadia Ahmed, Funeka Busakwe, Noluthando Mqaba, Derseree Archary, Aida Sivro, Natasha Samsunder, Disebo Potloane, William Horsnell, Christine Jordan, Quarraisha Abdool Karim, Linda-Gail Bekker, Jo-Ann Passmore, Heather Jaspan, Hilton Humphries, Lindi Masson","doi":"10.1136/sextrans-2024-056260","DOIUrl":"10.1136/sextrans-2024-056260","url":null,"abstract":"<p><strong>Objectives: </strong>In sub-Saharan Africa, approximately 86% of HIV infections in adolescents aged 15-19 years occur among girls. Their heightened susceptibility is likely influenced by converging sociobehavioural and biological factors, although the relative contributions remain unclear. To address this, we compared known and hypothesised risk factors for HIV between cisgender adolescent girls and adult women in South Africa and evaluated the relationships between these factors and sexually transmitted infection (STI) status.</p><p><strong>Methods: </strong>This cross-sectional observational study included adolescent (n=305; 14-19 years) and adult females (n=114; 25-35 years) in two South African provinces (Western Cape (WC), KwaZulu-Natal (KZN)). Demographic and sociobehavioural data were collected by questionnaire. Colposcopy was conducted to identify cervicovaginal abnormalities, and tests for bacterial vaginosis (BV), <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae</i> and <i>Trichomonas vaginalis</i> were performed.</p><p><strong>Results: </strong>Adults reported higher risk sexual behaviour than adolescents across multiple variables, although adolescents were more likely to have STIs than adults (62.8% vs 34.0%, respectively, p=0.0010 for WC; 42.5% vs 16.4%, respectively, p=0.0002 for KZN). Adolescents did, however, report earlier sexual debut (16 years old vs 17 years old, p<0.0001 for both sites) and KZN adolescents were more likely to use intravaginal sexual enhancers than adults (34.6% vs 20.6%, respectively, p=0.0417). Numbers of sexual partners (β-coefficient: 0.34, SE: 0.12, p=0.0054) and sex acts within the previous 3 months (β-coefficient: 0.25, SE: 0.09, p=0.0062) were associated with STIs in adolescents and trended to significance for adults. Intravaginal sexual enhancer use (KZN only; β-coefficient: 0.95, SE: 0.38, p=0.0118) and biological risk factors, including BV Nugent score (β-coefficient: 0.09, SE: 0.04, p=0.0257) and signs of cervicovaginal injury/inflammation (β-coefficient: 1.07, SE: 0.45, p=0.0171), were associated with STIs in adolescents but not adults.</p><p><strong>Conclusions: </strong>Risk factors for STIs including HIV may differ between age groups of girls and women, and mitigation interventions may need to be tailored accordingly.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"174-182"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Centenary Series - STIs Through the Ages: <b>From mercury to penicillin-a brief history of syphilis treatments</b>.","authors":"Jennifer Stephenson","doi":"10.1136/sextrans-2024-056365","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056365","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":"101 3","pages":"141-143"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the association between naturally induced IgG, IgM and neutralising antibodies to HPV16 and newly detected cervical HPV16 infection outcomes.","authors":"Andrea Trevisan, Patricia S de Araujo-Souza, Alix Pincivy, Joseph Niyibizi, Eduardo L Franco, Helen Trottier","doi":"10.1136/sextrans-2024-056296","DOIUrl":"10.1136/sextrans-2024-056296","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether recurrent cervical human papillomavirus type 16 (HPV16) infections can be prevented by naturally induced HPV16 antibodies in unvaccinated healthy women.</p><p><strong>Methods: </strong>We systematically searched the literature for studies that prospectively evaluated the association between HPV16 naturally induced IgG, IgM, and neutralising antibodies and newly detected cervical HPV16 infection in unvaccinated women. Data were quantitatively summarised by random effect meta-analysis.</p><p><strong>Results: </strong>Naturally induced HPV16 IgG and neutralising antibodies were negatively associated with newly detected HPV16 infection (relative risk (RR) (95% confidence interval (CI))=0.71 (0.63 to 0.80) and 0.54 (0.36 to 0.73), respectively). HPV16 antibodies tend to offer protection against subsequent HPV16 DNA detection in young women (RR (95% CI)=0.65 (0.55 to 0.74)), but not in women aged over 25 years (RR (95% CI)=0.88 (0.73 to 1.04)). HPV16 IgG antibodies were also negatively associated with persistent HPV16 infection (adjusted RR=0.67 (0.56 to 0.78)). There was high heterogeneity between studies (I² statistic=63.9%; p=0.007), and most had low risk of bias. We did not find studies evaluating IgM antibodies.</p><p><strong>Conclusion: </strong>Seroreactivity to HPV16 infection seems to provide moderate protection against newly detected cervical HPV16 infection outcomes in unvaccinated women. However, protection seems to be affected by age. These findings should be considered when evaluating public health interventions against HPV.</p><p><strong>Prospero registration number: </strong>CRD42022339579.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"191-199"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in <i>Neisseria gonorrhoeae</i> infections after ending COVID-19 lockdown measures in Amsterdam, the Netherlands.","authors":"Buhari Teker, Maarten F Schim van der Loeff, Anders Boyd, Elske Hoornenborg, Arjen J Stam, Henry J C de Vries, Vita Willemijn Jongen","doi":"10.1136/sextrans-2024-056276","DOIUrl":"10.1136/sextrans-2024-056276","url":null,"abstract":"<p><strong>Objective: </strong>Various European countries noted increasing <i>Neisseria gonorrhoeae</i> (Ng) positivity among cis-gender women and heterosexual men. We assessed changes over time in Ng among men who exclusively have sex with men (MSM), men who exclusively have sex with women (MSW), men who have sex with men and women (MSMW), women and transgender and gender diverse people (TGP).</p><p><strong>Methods: </strong>We analysed data collected between 2018 and 2023 at the Centre for Sexual Health, Amsterdam. We modelled temporal changes in Ng positivity rates (ie, number of positive results per 100 tests) using relative risk regression with a covariate representing three time periods: pre-COVID-19 (1 January 2018-12 March 2020), during COVID-19 (13 March 2020-1 March 2022), and post-COVID-19 (2 March 2022-31 December 2023).</p><p><strong>Results: </strong>We included 110 878 consultations pre-COVID-19, 84 917 during COVID-19 and 108 282 post-COVID-19. Positivity rates of Ng went from 12.4% to 13.0% in MSM, 1.7% to 2.3% in MSW, 6.7% to 9.9% in MSMW, 1.3% to 2.9% in women and 8.1% to 10.4% in TGP pre-COVID-19 and post-COVID-19, respectively. Significant increases were observed among MSW (relative risk (RR)=1.31,95% CI 1.12 to 1.53), MSMW (RR=1.47, 95% CI 1.26 to 1.72) and women (RR=2.25, 95% CI 2.03 to 2.49). An increased number of sexual partners and inconsistent condom use were associated with an increased Ng risk.</p><p><strong>Conclusion: </strong>A substantial relative increase in Ng risk among MSW, MSMW and women, but not MSM or TGP, was observed post-COVID-19. Changes in sexual behaviour were associated with these changes. Continuous surveillance of Ng in heterosexual individuals is needed to monitor changes, alongside implementing prevention strategies for sexually transmitted infections.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"152-159"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}