Sexually Transmitted Infections最新文献

{"title":"Doxycycline postexposure prophylaxis (doxyPEP): sexual health clinicians' knowledge and readiness.","authors":"Carys Phillips, Marisa Vinuesa, Clare Fowler, Suneeta Soni, Daniel Richardson","doi":"10.1136/sextrans-2024-056388","DOIUrl":"10.1136/sextrans-2024-056388","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"132"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do men who have sex with men recognise syphilis symptoms? A syphilis awareness campaign in Amsterdam, the Netherlands.","authors":"Silvia Achia Nieuwenburg, Arjan van Bijnen, Koenraad Vermey, Arjen Stam, Wim Zuilhof, Elske Hoornenborg, Maarten Franciscus Schim van der Loeff, Henry John Christiaan de Vries","doi":"10.1136/sextrans-2023-055925","DOIUrl":"10.1136/sextrans-2023-055925","url":null,"abstract":"<p><strong>Introduction: </strong>Syphilis incidence is rising among gay, bisexual and other men who have sex with men (GBMSM). To improve early health-seeking behaviour, we developed an online syphilis symptom score tool for GBMSM to self-identify a higher likelihood of infectious syphilis and promoted its use via an online and offline awareness campaign.</p><p><strong>Methods: </strong>From October 2018 through September 2019, a dedicated website on syphilis including the online symptom score tool was promoted. The reach of the campaign was measured by website metrics and the completion of the self-assessment tool. The impact of the campaign was assessed by comparing the monthly number of syphilis serology tests and the percentages of infectious syphilis diagnoses at the Centre for Sexual Health (CSH) in Amsterdam between three periods: 12 months preceding, 12 months during and 6 months after the campaign.</p><p><strong>Results: </strong>During the campaign, 20 341 visitors viewed the website. A total of 13 499 (66.4%) visitors started the self-assessment algorithm, and 11 626 (86.1%) completed it. Prior to the campaign, the mean number of syphilis tests per month was 1650 compared with 1806 per month during the campaign (p=0.02). In the 6 months after the campaign, the mean number of tests per month was 1798 (compared with the period of the campaign, p=0.94). Prior to the campaign, the percentage of infectious syphilis diagnoses was 2.5% compared with 3.0% during the campaign (p=0.009). The percentage of infectious syphilis diagnoses in the 6 months after the campaign was 2.2% (p<0.0001 compared with the period of the campaign, and p=0.045, compared with the period prior to the campaign).</p><p><strong>Conclusions: </strong>Although we did not find definite proof of a (sustained) effect, syphilis symptoms awareness campaigns deserve further evaluation and improvements to help those suspected of syphilis to get tested.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"118-120"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and opportunities for hepatitis B virus screening in people attending PrEP services: a retrospective prevalence study.","authors":"Bianca Monti, Roberto Rossotti, Fabiana D'Aloia, Daniele Calzavara, Laura Corsico, Massimo Cernuschi, Massimo Puoti, Paolo Bonfanti, Alessandro Soria","doi":"10.1136/sextrans-2024-056245","DOIUrl":"10.1136/sextrans-2024-056245","url":null,"abstract":"<p><strong>Objectives: </strong>Pre-exposure prophylaxis (PrEP) with emtricitabine/tenofovir to prevent HIV in individuals with hepatitis B virus (HBV) raises concerns about HBV reactivation when stopping event-driven PrEP or redundancy in HBV treatment for continuous PrEP (since tenofovir alone would be enough for HBV). Real-world data from PrEP services could provide useful epidemiological information on HBV prevalence in PrEP attendees in low-prevalence countries.</p><p><strong>Methods: </strong>A retrospective analysis on PrEP attendees of three services in northern Italy were conducted to assess HBV prevalence among PrEP attendees and the need for primary cycle/booster dose HBV vaccination despite previous vaccination during childhood (at birth or 12 years). Risk factors possibly associated with HBV exposure were evaluated with a binary logistic regression analysis, controlling for age, gender, place of birth (Italy vs abroad) and chemsex use (as a proxy of high-risk sexual behaviour for contracting sexually transmitted infections).</p><p><strong>Results: </strong>Among 10 hepatitis B surface antigen (HBsAg)-positive out of 2152 PrEP attendees (0.46%), PrEP was started in 7 subjects mainly with a daily schedule, 1 has declined after counselling, 2 were lost to follow-up. Around three-fourth of the 2152 PrEP attendees were born in Italy after 1979, thus were previously vaccinated during childhood. The probability of needing a booster for low-titre HBs antibodies was higher among those vaccinated at birth with respect to those vaccinated at 12 years (OR 2.30, 95% CI 1.80 to 2.96). The risk of previous HBV exposure (resulting in either HBsAg+ or antibodies against HBV core antigen [HBcAb]+) was higher for increasing age (OR 3.07, 95% CI 2.49 to 3.78 per 10 years more) and lower for being born in Italy (OR 0.23, 95% CI 0.14 to 0.36).</p><p><strong>Conclusions: </strong>Our real-world data on a large PrEP cohort suggest that, although uncommon, HBV infection in PrEP users in low-prevalence countries should be considered and managed. In addition, HBV screening offers the opportunity to expand prevention services through vaccination.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":"121-124"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Clostridioides difficile</i> infection following self-directed post-exposure antibiotic use for STI prevention.","authors":"Angelo Roberto Raccagni, Flavia Passini, Elena Bruzzesi, Flavia Badalucco Ciotta, Simona Bossolasco, Antonella Castagna, Silvia Nozza","doi":"10.1136/sextrans-2025-056479","DOIUrl":"https://doi.org/10.1136/sextrans-2025-056479","url":null,"abstract":"","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycoplasma genitalium</i> and antimicrobial resistance among the general female and male population in northern Spain.","authors":"Isabel Lara, Victor Hernandez-Ruiz, Miguel Fernández-Huerta, Jorge Rodriguez-Grande, Francisco Arnaiz De Las Revillas, Jesus Rodriguez-Lozano, Jorge Calvo-Montes, Alain Ocampo-Sosa, María Carmen Fariñas, Maria Pia Roiz Mesones, Sergio Garcia-Fernandez, Zaira Moure","doi":"10.1136/sextrans-2024-056374","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056374","url":null,"abstract":"<p><strong>Objectives: </strong><i>Mycoplasma genitalium</i> (MG) STIs represent a global concern, especially considering its rapid ability to acquire antimicrobial resistance. The objective of this study was to investigate the epidemiology of MG and antibiotic resistance among the general female and male populations in northern Spain.</p><p><strong>Methods: </strong>Between April 2019 and May 2023, individuals attending healthcare facilities for STI screening were tested for MG and macrolide and fluoroquinolone resistance mutations. Phylogenetic analysis was conducted using single-locus sequence-based typing of the <i>mgpB</i> gene and complemented by dual-locus sequence-based typing combining the <i>mgpB</i> and MG309 genes.</p><p><strong>Results: </strong>Of the 6350 people tested for MG during the study period, 5269 (83%) were women. Macrolide resistance mutations were identified in 25.4% of cases, with a higher prevalence in men (40% vs 17.14%) and coinfection with <i>Chlamydia trachomatis</i> was found predominantly in women (18.6% vs 7.5%). Phylogenetic analysis revealed two distinct epidemiological clades strongly correlated with gender. Clade A predominantly involved men with higher rates of HIV and syphilis history and detection of resistance mutations, while clade B exclusively comprised women, with only one case of macrolide resistance.</p><p><strong>Conclusions: </strong>The predominance of women in STI screening requests reflects local trends in screening patterns and underscores the importance of understanding MG infection in women in our region. The clear separation of clades suggests two independent sexual networks, with clade A representing a high-risk population and dense connectivity. This research provides a foundation for future studies on the prevalence, transmission dynamics and impact of MG infection, particularly among the female population, where understanding remains limited.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of a syndemic of STI symptoms, substance use and violence among incarcerated Peruvian women.","authors":"Elena Cyrus, Rodman Turpin, Typhanye Dyer, Elika Hashemi, Sobur Ali, Andrea Cornejo Bazo, Antonio Morgan-Lopez, Joy D Scheidell, Segundo R Leon, Michael Sciaudone, Frederick L Altice","doi":"10.1136/sextrans-2024-056371","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056371","url":null,"abstract":"<p><strong>Objectives: </strong>Despite parallel global trends of increasing incarceration rates and sexually transmitted infections (STIs) among women, STI epidemiological data for this vulnerable at-risk population are limited. The study objective was to characterise patterns of STI symptoms and explore covariates and drivers of indicating STI symptoms using syndemic theory among a population of incarcerated women in Peru.</p><p><strong>Methods: </strong>In a cross-sectional study, a sample of 249 incarcerated women responded to a questionnaire on substance use, depression, sexual behaviour, STI symptoms and violence, among other variables, between May and July 2015 in Santa Manica Prison (Lima, Peru). Univariate and bivariate analyses informed a latent profile analysis (LPA) and logistic regression.</p><p><strong>Results: </strong>Most women (93.5%) were Peruvian; 86.6% had prison sentences <5 years; the median age was 37 years (range 18-70 years); 2.6% were pregnant, 7.2% had children residing with them in prison; most women (78.7%) had a high school degree; >1/3 of the sample had ≥2 STI symptoms. The LPA analysis revealed that 39% of the sample had a 'syndemic' profile (co-occurrence of multiple STI symptoms, experiences of violence and substance use). Approximately 87% of women who were characterised by the syndemic profile were <50 years of age. The 'syndemic' profile was associated with double the prevalence of having multiple STI symptoms (≥2 symptoms: Prevalence Ratio (PR)=1.88 (95% CI 1.18, 2.99); ≥3 symptoms: PR=2.55 (95% CI 1.32, 4.93)).</p><p><strong>Conclusions: </strong>To address this syndemic, younger incarcerated women presenting with co-occurring STI symptoms (>2) can be clinically screened for diagnosis and treatment and assessed for substance use and risk of violence. Further research in this area may help stem and prevent deleterious health outcomes, including STIs, abuse and substance misuse, that can impact the individual and families.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> detected in Scotland, 2018-2024.","authors":"Martin P McHugh, Kirsty Aburajab, Alexandra Maxwell, John Anderson, Fraser Cairns, Seb Cotton, Andrew Gough, Brian Malloy, Katharine Mathers, Lynne Renwick, Jill Shepherd, Kate E Templeton","doi":"10.1136/sextrans-2024-056405","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056405","url":null,"abstract":"<p><strong>Objectives: </strong>Describe the clinical, phenotypic and genomic characteristics of ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> from Scotland.</p><p><strong>Methods: </strong>Cases were identified in routine care from 2018 to 2024. Minimum inhibitory concentrations were determined for seven antimicrobial agents. Whole genome sequencing was performed with Illumina and Oxford Nanopore Technology instruments. A phylogeny containing global ceftriaxone-resistant genomes was generated with Parsnp. A collection of ST8780 genomes was also analysed to give further context using reference-based mapping with Snippy.</p><p><strong>Results: </strong>There were five cases of ceftriaxone-resistant <i>N. gonorrhoeae</i> detected. One case (multilocus sequencing typing (MLST) ST1903) clustered within the FC428 lineage in a returning traveller from an Asia-Pacific country. Two cases belonged to the recently described extensively drug-resistant MLST ST16406, a returning traveller from an Asia-Pacific country and a sexual contact within Scotland. The final two cases were a resident of an Asia-Pacific country and a sexual contact within Scotland, both belonged to MLST ST8780. These were distinct from other publicly available ST8780 genomes, suggesting a novel introduction of the mosaic <i>penA</i>-60.001 allele. All cases were initially treated with ceftriaxone-based regimes, four returned for test of cure and showed clearance of infection.</p><p><strong>Conclusions: </strong>As ceftriaxone resistance is increasingly identified, multiple public health interventions are required to reduce the impact of resistance on gonorrhoea treatment globally.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of prenatal care in pregnancies complicated by syphilis: trend, risk factors and outcomes.","authors":"Han-Yang Chen, Irene A Stafford","doi":"10.1136/sextrans-2024-056453","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056453","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the temporal trend and risk factors associated with lack of prenatal care and the association between lack of prenatal care and adverse outcomes in pregnancies complicated by syphilis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using US vital statistic data (2016-2022). We included non-anomalous, singleton live births delivered by pregnancies complicated by syphilis at 24-42 weeks of gestation in a hospital. The exposure variable was prenatal care (had care vs no care). We used Adequacy of Prenatal Care Utilization Index. Adverse outcomes were examined. The annual per cent change (APC) was calculated to assess the trend of lacking prenatal care. Multivariable Poisson regression models with robust error variance were used to examine the association. Adjusted relative risks (aRR) with 95% CIs were calculated.</p><p><strong>Results: </strong>Among the study population of 38 583 live births, 2417 (6.3%) lacked prenatal care. The rate of lacking prenatal care increased over time (APC=11.4; 95% CI 4.7 to 18.5). Maternal education, insurance, nulliparity, prepregnancy body mass index, prior preterm birth, smoking, diabetes, hepatitis C and year of delivery were associated with lacking prenatal care. Compared with individuals with prenatal care, those without care were associated with a higher risk of preterm birth <37 weeks (aRR 2.57; 95% CI 2.40 to 2.74) and <34 weeks (aRR 3.56; 95% CI 3.13 to 4.05). Compared with patients with adequate care, those without care were associated with a higher risk of preterm birth <37 weeks (aRR 5.07; 95% CI 4.59 to 5.60) and <34 weeks (aRR 6.42; 95% CI 5.32 to 7.75). Similar associations were shown in other adverse outcomes.</p><p><strong>Conclusions: </strong>Among pregnancies complicated by syphilis in the USA, there was an upward trend in lack of prenatal care from 2016 to 2022. Modifiable factors of lacking prenatal care were identified. The risks of adverse outcomes were higher among individuals without prenatal care.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are we missing? Data from the Gonorrhoea Undetected Resistance Laboratory Study (GURLS).","authors":"Michelle Jayne Cole, Anna Vickers, Suzy Sun, Michaela Joanne Day, Ross Harris, Laura Burgess Tornaletti, Katie Thorley, Hussain Ahmed, Monica Rebec, Miriam O'Connor, Soma N'Jai-Ndimbalan, Alan Lord, Mark Hopkins, Paul Grant, Peter Muir, Kate Sibson, Hamish Mohammed, Katy Sinka, Rachel Pitt-Kendall, Helen Fifer","doi":"10.1136/sextrans-2024-056459","DOIUrl":"https://doi.org/10.1136/sextrans-2024-056459","url":null,"abstract":"<p><strong>Objectives: </strong>Increasing ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> is of public health concern. A cluster of ceftriaxone-resistant <i>N. gonorrhoeae</i> was identified in 2022, which was linked to heterosexuals from the Asia-Pacific region who were studying at UK universities. The possibility of further transmission within and beyond this network was of concern, particularly as not all gonococcal cases have a positive culture for antimicrobial susceptibility testing to be performed. We, therefore, undertook a case finding exercise using an <i>N. gonorrhoeae penA</i> real-time PCR to identify undetected transmission of ceftriaxone-resistant strains. The PCR detects <i>penA</i>-60.001, which is the most common gonococcal ceftriaxone-resistance mechanism. The aim of this Gonorrhoea Undetected Resistance Laboratory Study was to estimate the prevalence of undetected ceftriaxone-resistant <i>N. gonorrhoeae</i> in England.</p><p><strong>Methods: </strong>Sexually transmitted infection surveillance data (2017-2021) was combined with university data on student country of origin to identify sexual health services in English university towns with the highest number of gonorrhoea cases among those of Asian ethnicity born in selected countries of the Asia-Pacific region. Residual <i>N. gonorrhoeae</i>-positive molecular specimens from women (as a proxy for heterosexual behaviour) aged 18-30 years were sent to the UK Health Security Agency (UKHSA) for testing.</p><p><strong>Results: </strong>Between February 2023 and March 2024, 921 specimens meeting the inclusion criteria were received, of which 661 were reconfirmed as <i>N. gonorrhoeae</i>. Of these, one was positive on the <i>penA</i> PCR, indicating ceftriaxone resistance; this specimen came from a previously identified case, therefore no 'undetected' cases were identified.</p><p><strong>Conclusions: </strong>This case-finding exercise provided reassurance that ceftriaxone-resistant <i>N. gonorrhoeae</i> in England is currently adequately detected through the existing UKHSA-enhanced surveillance activities. The current <i>penA</i> PCR is a useful tool in the fight to keep gonorrhoea a treatable infection; however, it requires expansion as it does not currently detect all <i>penA</i> alleles responsible for ceftriaxone resistance.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus vaccination uptake among men who have sex with men living with HIV.","authors":"Conor Moran, Jaime Garcia-Iglesias, Colm Kerr","doi":"10.1136/sextrans-2024-056361","DOIUrl":"10.1136/sextrans-2024-056361","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is a very common sexually transmitted infection. Persistent infection with high-risk subtypes can lead to a variety of cancers. Men who have sex with men (MSM), particularly those who are living with HIV (MSMLWH), have a high prevalence of HPV infection and are at greatest risk of HPV-related diseases such as anal cancer. HPV vaccines are effective in preventing new infections, and many countries have implemented HPV vaccination for MSM.</p><p><strong>Methods: </strong>This systematic review aimed to examine HPV vaccine uptake among MSM and MSMLWH. Quantitative studies published between 2010 and 2022 were screened and included if they detailed HPV vaccination uptake data for MSM and MSMLWH. Identified studies were screened using Covidence, data were extracted from the final included studies and narratively synthesised, and risk of bias of studies was assessed using the Joanna Briggs Institute Checklist tool for prevalence studies.</p><p><strong>Results: </strong>There were 19 studies all from high-income countries, included in the final review. This review showed a wide variety of HPV vaccine uptake, ranging from 2.7% to 91.5% for HIV-negative MSM and among MSMLWH ranging from 5.6% to 90%. Although limited by the heterogeneity of studies and settings, there was evidence of a consistent, steady increase in HPV vaccination particularly among younger men. MSMLWH generally had higher rates of HPV vaccination, but overall HPV vaccine uptake remained suboptimal.</p><p><strong>Conclusion: </strong>MSMLWH are at high risk of HPV-related disease. Despite an available and efficacious vaccine in many countries, this review showed overall rates of HPV vaccination uptake remain inadequate. Further research and policy should aim to address and overcome barriers to HPV vaccination.PROSPERO registration numberCRD42023382251.</p>","PeriodicalId":21624,"journal":{"name":"Sexually Transmitted Infections","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}